---
_id: '4033'
abstract:
- lang: eng
text: 'A collection of geometric selection lemmas is proved, such as the following:
For any set P of n points in three-dimensional space and any set S of m spheres,
where each sphere passes through a distinct point pair in P. there exists a point
x, not necessarily in P, that is enclosed by Ω(m2/(n2 log6 n2/m)) of the spheres
in S. Similar results apply in arbitrary fixed dimensions, and for geometric bodies
other than spheres. The results have applications in reducing the size of geometric
structures, such as three-dimensional Delaunay triangulations and Gabriel graphs,
by adding extra points to their defining sets.'
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: John
full_name: Hershberger, John
last_name: Hershberger
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Chazelle B, Edelsbrunner H, Guibas L, Hershberger J, Seidel R, Sharir M. Selecting
heavily covered points. SIAM Journal on Computing. 1994;23(6):1138-1151.
doi:10.1137/S0097539790179919
apa: Chazelle, B., Edelsbrunner, H., Guibas, L., Hershberger, J., Seidel, R., &
Sharir, M. (1994). Selecting heavily covered points. SIAM Journal on Computing.
SIAM. https://doi.org/10.1137/S0097539790179919
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, John Hershberger,
Raimund Seidel, and Micha Sharir. “Selecting Heavily Covered Points.” SIAM
Journal on Computing. SIAM, 1994. https://doi.org/10.1137/S0097539790179919 .
ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, J. Hershberger, R. Seidel, and M.
Sharir, “Selecting heavily covered points,” SIAM Journal on Computing,
vol. 23, no. 6. SIAM, pp. 1138–1151, 1994.
ista: Chazelle B, Edelsbrunner H, Guibas L, Hershberger J, Seidel R, Sharir M. 1994.
Selecting heavily covered points. SIAM Journal on Computing. 23(6), 1138–1151.
mla: Chazelle, Bernard, et al. “Selecting Heavily Covered Points.” SIAM Journal
on Computing, vol. 23, no. 6, SIAM, 1994, pp. 1138–51, doi:10.1137/S0097539790179919 .
short: B. Chazelle, H. Edelsbrunner, L. Guibas, J. Hershberger, R. Seidel, M. Sharir,
SIAM Journal on Computing 23 (1994) 1138–1151.
date_created: 2018-12-11T12:06:33Z
date_published: 1994-12-01T00:00:00Z
date_updated: 2022-06-03T06:41:56Z
day: '01'
doi: '10.1137/S0097539790179919 '
extern: '1'
intvolume: ' 23'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/S0097539790179919
month: '12'
oa_version: None
page: 1138 - 1151
publication: SIAM Journal on Computing
publication_identifier:
issn:
- 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2092'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selecting heavily covered points
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 23
year: '1994'
...
---
_id: '4037'
abstract:
- lang: eng
text: Frequently, data in scientific computing is in its abstract form a finite
point set in space, and it is sometimes useful or required to compute what one
might call the `'shape” of the set. For that purpose, this article introduces
the formal notion of the family of alpha-shapes of a finite point set in R3. Each
shape is a well-defined polytope, derived from the Delaunay triangulation of the
point set, with a parameter alpha is-an-element-of R controlling the desired level
of detail. An algorithm is presented that constructs the entire family of shapes
for a given set of size n in time O(n2), worst case. A robust implementation of
the algorithm is discussed, and several applications in the area of scientific
computing are mentioned.
acknowledgement: National Science Foundation under grant CCR-8921421 and Alan T.
Waterman award, grant CCR-9118874.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ernst
full_name: Mücke, Ernst
last_name: Mücke
citation:
ama: Edelsbrunner H, Mücke E. Three-dimensional alpha shapes. ACM Transactions
on Graphics. 1994;13(1):43-72. doi:10.1145/174462.156635
apa: Edelsbrunner, H., & Mücke, E. (1994). Three-dimensional alpha shapes. ACM
Transactions on Graphics. ACM. https://doi.org/10.1145/174462.156635
chicago: Edelsbrunner, Herbert, and Ernst Mücke. “Three-Dimensional Alpha Shapes.”
ACM Transactions on Graphics. ACM, 1994. https://doi.org/10.1145/174462.156635.
ieee: H. Edelsbrunner and E. Mücke, “Three-dimensional alpha shapes,” ACM Transactions
on Graphics, vol. 13, no. 1. ACM, pp. 43–72, 1994.
ista: Edelsbrunner H, Mücke E. 1994. Three-dimensional alpha shapes. ACM Transactions
on Graphics. 13(1), 43–72.
mla: Edelsbrunner, Herbert, and Ernst Mücke. “Three-Dimensional Alpha Shapes.” ACM
Transactions on Graphics, vol. 13, no. 1, ACM, 1994, pp. 43–72, doi:10.1145/174462.156635.
short: H. Edelsbrunner, E. Mücke, ACM Transactions on Graphics 13 (1994) 43–72.
date_created: 2018-12-11T12:06:34Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T12:00:42Z
day: '01'
doi: 10.1145/174462.156635
extern: '1'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://dl.acm.org/doi/10.1145/174462.156635
month: '01'
oa: 1
oa_version: None
page: 43 - 72
publication: ACM Transactions on Graphics
publication_status: published
publisher: ACM
publist_id: '2088'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Three-dimensional alpha shapes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1994'
...
---
_id: '4038'
abstract:
- lang: eng
text: We consider a variety of problems on the interaction between two sets of line
segments in two and three dimensions. These problems range from counting the number
of intersecting pairs between m blue segments and n red segments in the plane
(assuming that two line segments are disjoint if they have the same color) to
finding the smallest vertical distance between two nonintersecting polyhedral
terrains in three-dimensional space. We solve these problems efficiently by using
a variant of the segment tree. For the three-dimensional problems we also apply
a variety of recent combinatorial and algorithmic techniques involving arrangements
of lines in three-dimensional space, as developed in a companion paper.
acknowledgement: Supported in part by the National Science Foundation under Grant
CCR-8714565.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. Algorithms for bichromatic
line-segment problems and polyhedral terrains. Algorithmica. 1994;11(2):116-132.
doi:10.1007/BF01182771
apa: Chazelle, B., Edelsbrunner, H., Guibas, L., & Sharir, M. (1994). Algorithms
for bichromatic line-segment problems and polyhedral terrains. Algorithmica.
Springer. https://doi.org/10.1007/BF01182771
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
“Algorithms for Bichromatic Line-Segment Problems and Polyhedral Terrains.” Algorithmica.
Springer, 1994. https://doi.org/10.1007/BF01182771.
ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “Algorithms for bichromatic
line-segment problems and polyhedral terrains,” Algorithmica, vol. 11,
no. 2. Springer, pp. 116–132, 1994.
ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1994. Algorithms for bichromatic
line-segment problems and polyhedral terrains. Algorithmica. 11(2), 116–132.
mla: Chazelle, Bernard, et al. “Algorithms for Bichromatic Line-Segment Problems
and Polyhedral Terrains.” Algorithmica, vol. 11, no. 2, Springer, 1994,
pp. 116–32, doi:10.1007/BF01182771.
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Algorithmica 11 (1994)
116–132.
date_created: 2018-12-11T12:06:34Z
date_published: 1994-02-01T00:00:00Z
date_updated: 2022-06-02T12:25:29Z
day: '01'
doi: 10.1007/BF01182771
extern: '1'
intvolume: ' 11'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01182771
month: '02'
oa_version: None
page: 116 - 132
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2089'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithms for bichromatic line-segment problems and polyhedral terrains
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1994'
...
---
_id: '4039'
abstract:
- lang: eng
text: Let P be a simple polygon with n vertices. We present a simple decomposition
scheme that partitions the interior of P into O(n) so-called geodesic triangles,
so that any line segment interior to P crosses at most 2 log n of these triangles.
This decomposition can be used to preprocess P in a very simple manner, so that
any ray-shooting query can be answered in time O(log n). The data structure requires
O(n) storage and O(n log n) preprocessing time. By using more sophisticated techniques,
we can reduce the preprocessing time to O(n). We also extend our general technique
to the case of ray shooting amidst k polygonal obstacles with a total of n edges,
so that a query can be answered in O(√ log n) time.
acknowledgement: Work by Bernard Chazelle has been supported by NSF Grant CCR-87-00917.
Work by Herbert Edelsbrunner has been supported by NSF Grant CCR-89-21421. Work
by Micha Sharir has been supported by ONR Grants N00014-89-J-3042 and N00014-90-J-1284,
by NSF Grant CCR-89-01484, and by grants from the U.S.-Israeli Binational Science
Foundation, the Fund for Basic Research administered by the Israeli Academy of Sciences,
and the G.I.F., the German-Israeli Foundation for Scientific Research and Development.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michelangelo
full_name: Grigni, Michelangelo
last_name: Grigni
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: John
full_name: Hershberger, John
last_name: Hershberger
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jack
full_name: Snoeyink, Jack
last_name: Snoeyink
citation:
ama: Chazelle B, Edelsbrunner H, Grigni M, et al. Ray shooting in polygons using
geodesic triangulations. Algorithmica. 1994;12(1):54-68. doi:10.1007/BF01377183
apa: Chazelle, B., Edelsbrunner, H., Grigni, M., Guibas, L., Hershberger, J., Sharir,
M., & Snoeyink, J. (1994). Ray shooting in polygons using geodesic triangulations.
Algorithmica. Springer. https://doi.org/10.1007/BF01377183
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Michelangelo Grigni, Leonidas
Guibas, John Hershberger, Micha Sharir, and Jack Snoeyink. “Ray Shooting in Polygons
Using Geodesic Triangulations.” Algorithmica. Springer, 1994. https://doi.org/10.1007/BF01377183.
ieee: B. Chazelle et al., “Ray shooting in polygons using geodesic triangulations,”
Algorithmica, vol. 12, no. 1. Springer, pp. 54–68, 1994.
ista: Chazelle B, Edelsbrunner H, Grigni M, Guibas L, Hershberger J, Sharir M, Snoeyink
J. 1994. Ray shooting in polygons using geodesic triangulations. Algorithmica.
12(1), 54–68.
mla: Chazelle, Bernard, et al. “Ray Shooting in Polygons Using Geodesic Triangulations.”
Algorithmica, vol. 12, no. 1, Springer, 1994, pp. 54–68, doi:10.1007/BF01377183.
short: B. Chazelle, H. Edelsbrunner, M. Grigni, L. Guibas, J. Hershberger, M. Sharir,
J. Snoeyink, Algorithmica 12 (1994) 54–68.
date_created: 2018-12-11T12:06:35Z
date_published: 1994-07-01T00:00:00Z
date_updated: 2022-06-02T12:41:07Z
day: '01'
doi: 10.1007/BF01377183
extern: '1'
intvolume: ' 12'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01377183
month: '07'
oa_version: None
page: 54 - 68
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2090'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ray shooting in polygons using geodesic triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1994'
...
---
_id: '4179'
abstract:
- lang: eng
text: Neurotrophin-3 (NT-3) is a member of the neurotrophin gene family and is highly
expressed in the developing rat cerebellum. Here we show that brain-derived neurotrophic
factor (BDNF) increased by approximately 10-fold the NT-3 mRNA levels in cultured
cerebellar granule neurons isolated from postnatal rats, whereas nerve growth
factor (NGF) and NT-3 itself had no effect. The effect of BDNF was additive to
that of triiodothyronine (T3), which also increased NT-3 mRNA in these neurons.
The drug K252a inhibited the BDNF-mediated stimulation of NT-3 expression, suggesting
an involvement of trkB receptors. Nuclear run-on experiments showed that BDNF
enhanced NT-3 transcription, whereas the stability of NT-3 mRNA remained unchanged.
The data presented are the first demonstration that one neurotrophin regulates
the expression of another and provide evidence that NT-3 production in granule
neurons is regulated by both BDNF and T3.
acknowledgement: We thank Dorothea Stratmann and Karin Angermayer for skillful technical
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Axel
full_name: Leingärtner, Axel
last_name: Leingärtner
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Roland
full_name: Kolbeck, Roland
last_name: Kolbeck
- first_name: Hans
full_name: Thoenen, Hans
last_name: Thoenen
- first_name: Dan
full_name: Lindholm, Dan
last_name: Lindholm
citation:
ama: Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. Brain-derived
neurotrophic factor increases neurotrophin-3 expression in cerebellar granule
neurons. Journal of Biological Chemistry. 1994;269(2):828-830. doi:10.1016/s0021-9258(17)42186-7
apa: Leingärtner, A., Heisenberg, C.-P. J., Kolbeck, R., Thoenen, H., & Lindholm,
D. (1994). Brain-derived neurotrophic factor increases neurotrophin-3 expression
in cerebellar granule neurons. Journal of Biological Chemistry. American
Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(17)42186-7
chicago: Leingärtner, Axel, Carl-Philipp J Heisenberg, Roland Kolbeck, Hans Thoenen,
and Dan Lindholm. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3
Expression in Cerebellar Granule Neurons.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 1994. https://doi.org/10.1016/s0021-9258(17)42186-7.
ieee: A. Leingärtner, C.-P. J. Heisenberg, R. Kolbeck, H. Thoenen, and D. Lindholm,
“Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar
granule neurons,” Journal of Biological Chemistry, vol. 269, no. 2. American
Society for Biochemistry and Molecular Biology, pp. 828–830, 1994.
ista: Leingärtner A, Heisenberg C-PJ, Kolbeck R, Thoenen H, Lindholm D. 1994. Brain-derived
neurotrophic factor increases neurotrophin-3 expression in cerebellar granule
neurons. Journal of Biological Chemistry. 269(2), 828–830.
mla: Leingärtner, Axel, et al. “Brain-Derived Neurotrophic Factor Increases Neurotrophin-3
Expression in Cerebellar Granule Neurons.” Journal of Biological Chemistry,
vol. 269, no. 2, American Society for Biochemistry and Molecular Biology, 1994,
pp. 828–30, doi:10.1016/s0021-9258(17)42186-7.
short: A. Leingärtner, C.-P.J. Heisenberg, R. Kolbeck, H. Thoenen, D. Lindholm,
Journal of Biological Chemistry 269 (1994) 828–830.
date_created: 2018-12-11T12:07:25Z
date_published: 1994-01-14T00:00:00Z
date_updated: 2022-06-02T10:23:48Z
day: '14'
doi: 10.1016/s0021-9258(17)42186-7
extern: '1'
intvolume: ' 269'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925817421867?via%3Dihub
month: '01'
oa: 1
oa_version: None
page: 828 - 830
publication: Journal of Biological Chemistry
publication_identifier:
eissn:
- 1083-351X
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '1941'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar
granule neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 269
year: '1994'
...
---
_id: '4202'
abstract:
- lang: eng
text: NERVE growth factor (NGF) injected into the otherwise unlesioned adult rat
septum induced sprouting of presumptive cholinergic fibres positive for p75(NGFR)
and acetylcholinesterase (AChE). These fibres did not stain for tyrosine hydroxylase
and therefore did not represent sympathetic ingrowth. Neurofilament staining on
adjacent sections revealed fibres with similar morphology, suggesting new outgrowth
in the form of sprouting rather than the upregulation of p75(NGFR) and AChE in
pre-existing fibres. Simultaneous injections of subneurotoxic doses of N-methyl-D-aspartate
(NMDA) significantly potentiated the effect of NGF on cholinergic fibre sprouting
and caused pronounced glial fibrillary acidic protein (GFAP)positive astrocytosis.
Application of NMDA alone did not elicit sprouting of this type. These findings
indicate that NGF can induce the sprouting of uninjured adult rat septal cholinergic
fibres in vivo and suggest that reactive astrocytes are not inhibitory to cholinergic
axonal outgrowth, and might serve as a substrate for growing axons in the presence
of NGF.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: John
full_name: Cooper, John
last_name: Cooper
- first_name: J
full_name: Berke, J
last_name: Berke
- first_name: Michael
full_name: Sofroniew, Michael
last_name: Sofroniew
citation:
ama: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. NMDA potentiates NGF-induced
sprouting of septal cholinergic fibres. Neuroreport. 1994;5(4):413-416.
doi:10.1097/00001756-199401120-00010
apa: Heisenberg, C.-P. J., Cooper, J., Berke, J., & Sofroniew, M. (1994). NMDA
potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport.
Lippincott, Williams & Wilkins. https://doi.org/10.1097/00001756-199401120-00010
chicago: Heisenberg, Carl-Philipp J, John Cooper, J Berke, and Michael Sofroniew.
“NMDA Potentiates NGF-Induced Sprouting of Septal Cholinergic Fibres.” Neuroreport.
Lippincott, Williams & Wilkins, 1994. https://doi.org/10.1097/00001756-199401120-00010 .
ieee: C.-P. J. Heisenberg, J. Cooper, J. Berke, and M. Sofroniew, “NMDA potentiates
NGF-induced sprouting of septal cholinergic fibres,” Neuroreport, vol.
5, no. 4. Lippincott, Williams & Wilkins, pp. 413–416, 1994.
ista: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. 1994. NMDA potentiates NGF-induced
sprouting of septal cholinergic fibres. Neuroreport. 5(4), 413–416.
mla: Heisenberg, Carl-Philipp J., et al. “NMDA Potentiates NGF-Induced Sprouting
of Septal Cholinergic Fibres.” Neuroreport, vol. 5, no. 4, Lippincott,
Williams & Wilkins, 1994, pp. 413–16, doi:10.1097/00001756-199401120-00010 .
short: C.-P.J. Heisenberg, J. Cooper, J. Berke, M. Sofroniew, Neuroreport 5 (1994)
413–416.
date_created: 2018-12-11T12:07:33Z
date_published: 1994-01-12T00:00:00Z
date_updated: 2022-06-02T10:07:25Z
day: '12'
doi: '10.1097/00001756-199401120-00010 '
extern: '1'
intvolume: ' 5'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/Abstract/1994/01120/NMDA_potentiates_NGF_induced_sprouting_of_septal.10.aspx
month: '01'
oa_version: None
page: 413 - 416
publication: Neuroreport
publication_identifier:
issn:
- 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1915'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NMDA potentiates NGF-induced sprouting of septal cholinergic fibres
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1994'
...
---
_id: '4420'
abstract:
- lang: eng
text: We propose a methodology for the specification, verification, and design of
hybrid systems. The methodology consists of the computational model of Concrete
Phase Transition Systems (cptss), the specification language of Hybrid Temporal
Logic (htl), the graphical system description language of Hybrid Automata, and
a proof system for verifying that hybrid automata satisfy their HTL specifications.
The novelty of the approach lies in the continuous-time logic, which allows specification
of both point-based and interval-based properties (i.e., properties which describe
changes over an interval) and provides direct references to derivatives of variables,
and in the proof system that supports verification of point-based and interval-based
properties. The proof rules demonstrate that sound and convenient induction rules
can be established for continuous-time logics. The proof rules are illustrated
on several examples.
acknowledgement: Supported in part by the National Science Foundation under grants
CCR-92-23226 and CCR-9200794, by the Defense Advanced Research Projects Agency under
grants NAG2-703 and NAG2-892, by the United States Air Force Office of Scientific
Research under contracts F49620-93-1-0139 and F49620-93-1-0056, and by the European
Community ESPRIT Basic Research Action Project 6021 (REACT). Supported in part by
a National Science Foundation Graduate Research Fellowship.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Arjun
full_name: Kapur, Arjun
last_name: Kapur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Zohar
full_name: Manna, Zohar
last_name: Manna
- first_name: Amir
full_name: Pnueli, Amir
last_name: Pnueli
citation:
ama: 'Kapur A, Henzinger TA, Manna Z, Pnueli A. Proving safety properties of hybrid
systems. In: 3rd International Symposium on Formal Techniques in Real-Time
and Fault-Tolerant Systems. Vol 863. Springer; 1994:431-454. doi:10.1007/3-540-58468-4_177'
apa: 'Kapur, A., Henzinger, T. A., Manna, Z., & Pnueli, A. (1994). Proving safety
properties of hybrid systems. In 3rd International Symposium on Formal Techniques
in Real-Time and Fault-Tolerant Systems (Vol. 863, pp. 431–454). Lübeck, Germany:
Springer. https://doi.org/10.1007/3-540-58468-4_177'
chicago: Kapur, Arjun, Thomas A Henzinger, Zohar Manna, and Amir Pnueli. “Proving
Safety Properties of Hybrid Systems.” In 3rd International Symposium on Formal
Techniques in Real-Time and Fault-Tolerant Systems, 863:431–54. Springer,
1994. https://doi.org/10.1007/3-540-58468-4_177.
ieee: A. Kapur, T. A. Henzinger, Z. Manna, and A. Pnueli, “Proving safety properties
of hybrid systems,” in 3rd International Symposium on Formal Techniques in
Real-Time and Fault-Tolerant Systems, Lübeck, Germany, 1994, vol. 863, pp.
431–454.
ista: 'Kapur A, Henzinger TA, Manna Z, Pnueli A. 1994. Proving safety properties
of hybrid systems. 3rd International Symposium on Formal Techniques in Real-Time
and Fault-Tolerant Systems. FTRTFT: Formal Techniques in Real-Time and Fault-Tolerant
Systems, LNCS, vol. 863, 431–454.'
mla: Kapur, Arjun, et al. “Proving Safety Properties of Hybrid Systems.” 3rd
International Symposium on Formal Techniques in Real-Time and Fault-Tolerant Systems,
vol. 863, Springer, 1994, pp. 431–54, doi:10.1007/3-540-58468-4_177.
short: A. Kapur, T.A. Henzinger, Z. Manna, A. Pnueli, in:, 3rd International Symposium
on Formal Techniques in Real-Time and Fault-Tolerant Systems, Springer, 1994,
pp. 431–454.
conference:
end_date: 1994-09-23
location: Lübeck, Germany
name: 'FTRTFT: Formal Techniques in Real-Time and Fault-Tolerant Systems'
start_date: 1994-09-19
date_created: 2018-12-11T12:08:46Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T09:46:37Z
day: '01'
doi: 10.1007/3-540-58468-4_177
extern: '1'
intvolume: ' 863'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-58468-4_177
month: '01'
oa_version: None
page: 431 - 454
publication: 3rd International Symposium on Formal Techniques in Real-Time and Fault-Tolerant
Systems
publication_status: published
publisher: Springer
publist_id: '309'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Proving safety properties of hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 863
year: '1994'
...
---
_id: '4440'
abstract:
- lang: eng
text: We present a methodology for proving temporal properties of the divergent
runs of reactive systems with real-valued clocks. A run diverges if time advances
beyond any bound. Since the divergent runs of a system may satisfy liveness properties
that are not satisfied by some convergent runs, the standard proof rules are incomplete
if only divergent runs are considered. First, we develop a sound and complete
proof calculus for divergence, which is based on translating clock systems into
discrete systems. Then, we show that simpler proofs can be obtained for stronger
divergence assumptions, such as unknown -divergence, which requires that all delays
have a minimum duration of some unknown constant . We classify all real-time systems
into an infinite hierarchy, according to how well they admit the translation of
eventuality properties into equivalent safety properties.
acknowledgement: Supported in part by the National Science Foundation under grant
CCR-9200794, by the United States Air Force Office of Scientific Research under
contract F49620- 93-1-0056, and by the Defense Advanced Research Projects Agency
under grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: 'Henzinger TA, Kopke P. Verification methods for the divergent runs of clock
systems. In: 3rd International Symposium on Formal Techniques in Real-Time
and Fault-Tolerant Systems. Vol 863. Springer; 1994:351-372. doi:10.1007/3-540-58468-4_173'
apa: 'Henzinger, T. A., & Kopke, P. (1994). Verification methods for the divergent
runs of clock systems. In 3rd International Symposium on Formal Techniques
in Real-Time and Fault-Tolerant Systems (Vol. 863, pp. 351–372). Lübeck, Gernany:
Springer. https://doi.org/10.1007/3-540-58468-4_173'
chicago: Henzinger, Thomas A, and Peter Kopke. “Verification Methods for the Divergent
Runs of Clock Systems.” In 3rd International Symposium on Formal Techniques
in Real-Time and Fault-Tolerant Systems, 863:351–72. Springer, 1994. https://doi.org/10.1007/3-540-58468-4_173.
ieee: T. A. Henzinger and P. Kopke, “Verification methods for the divergent runs
of clock systems,” in 3rd International Symposium on Formal Techniques in Real-Time
and Fault-Tolerant Systems, Lübeck, Gernany, 1994, vol. 863, pp. 351–372.
ista: 'Henzinger TA, Kopke P. 1994. Verification methods for the divergent runs
of clock systems. 3rd International Symposium on Formal Techniques in Real-Time
and Fault-Tolerant Systems. FTRTFT: Formal Techniques in Real-Time and Fault-Tolerant
Systems, LNCS, vol. 863, 351–372.'
mla: Henzinger, Thomas A., and Peter Kopke. “Verification Methods for the Divergent
Runs of Clock Systems.” 3rd International Symposium on Formal Techniques in
Real-Time and Fault-Tolerant Systems, vol. 863, Springer, 1994, pp. 351–72,
doi:10.1007/3-540-58468-4_173.
short: T.A. Henzinger, P. Kopke, in:, 3rd International Symposium on Formal Techniques
in Real-Time and Fault-Tolerant Systems, Springer, 1994, pp. 351–372.
conference:
end_date: 1994-09-23
location: Lübeck, Gernany
name: 'FTRTFT: Formal Techniques in Real-Time and Fault-Tolerant Systems'
start_date: 1994-09-19
date_created: 2018-12-11T12:08:52Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-02T09:35:58Z
day: '01'
doi: 10.1007/3-540-58468-4_173
extern: '1'
intvolume: ' 863'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-58468-4_173
month: '01'
oa_version: None
page: 351 - 372
publication: 3rd International Symposium on Formal Techniques in Real-Time and Fault-Tolerant
Systems
publication_status: published
publisher: Springer
publist_id: '287'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Verification methods for the divergent runs of clock systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 863
year: '1994'
...
---
_id: '4501'
abstract:
- lang: eng
text: 'We extend the specification language of temporal logic, the corresponding
verification framework, and the underlying computational model to deal with real-;time
properties of reactive systems. The abstract notion of timed transition systems
generalizes traditional transition systems conservatively: qualitative fairness
requirements are replaced (and superseded) by quantitative lower-bound and upper-bound
timing constraints on transitions. This framework can model real-time systems
that communicate either through shared variables or by message passing and real-time
issues such as timeouts, process priorities (interrupts), and process scheduling.
We exhibit two styles for the specification of real-time systems. While the first
approach uses time-bounded versions of the temporal operators, the second approach
allows explicit references to time through a special clock variable. Corresponding
to the two styles of specification, we present and compare two different proof
methodologies for the verification of timing requirements that are expressed in
these styles. For the bounded-operator style, we provide a set of proof rules
for establishing bounded-invariance and bounded-responce properties of timed transition
systems. This approach generalizes the standard temporal proof rules for verifying
invariance and response properties conservatively. For the explicit-clock style,
we exploit the observation that every time-bounded property is a safety property
and use the standard temporal proof rules for establishing safety properties.'
acknowledgement: 'This research was supported in part by an IBM graduate fellowship,
by the National Science Foundation under Grants CCR-9223226 and CCR-9200794. by
the Defense Advanced Research Projects Agency under Contract N00039-84-C-0211. by
the United States Air Force OMee of Scientific Research under Contracts F49620-93-141139
and F4962043-1-0056. and by the European Community ESPRIT Basic Research Action
Project 6021 (REACT). A preliminary version of Part 1 of this paper appeared in
the proceedings of the 1991 REX Workshop on Real Time Theory In Prate [HMP92a I
a preliminary version of Part II appeared in the proceedings of the 1991 ACM Symposium
on Principles of Programming Languages RIMP911. '
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Zohar
full_name: Manna, Zohar
last_name: Manna
- first_name: Amir
full_name: Pnueli, Amir
last_name: Pnueli
citation:
ama: Henzinger TA, Manna Z, Pnueli A. Temporal proof methodologies for timed transition
systems. Information and Computation. 1994;112(2):273-337. doi:10.1006/inco.1994.1060
apa: Henzinger, T. A., Manna, Z., & Pnueli, A. (1994). Temporal proof methodologies
for timed transition systems. Information and Computation. Elsevier. https://doi.org/10.1006/inco.1994.1060
chicago: Henzinger, Thomas A, Zohar Manna, and Amir Pnueli. “Temporal Proof Methodologies
for Timed Transition Systems.” Information and Computation. Elsevier, 1994.
https://doi.org/10.1006/inco.1994.1060.
ieee: T. A. Henzinger, Z. Manna, and A. Pnueli, “Temporal proof methodologies for
timed transition systems,” Information and Computation, vol. 112, no. 2.
Elsevier, pp. 273–337, 1994.
ista: Henzinger TA, Manna Z, Pnueli A. 1994. Temporal proof methodologies for timed
transition systems. Information and Computation. 112(2), 273–337.
mla: Henzinger, Thomas A., et al. “Temporal Proof Methodologies for Timed Transition
Systems.” Information and Computation, vol. 112, no. 2, Elsevier, 1994,
pp. 273–337, doi:10.1006/inco.1994.1060.
short: T.A. Henzinger, Z. Manna, A. Pnueli, Information and Computation 112 (1994)
273–337.
date_created: 2018-12-11T12:09:10Z
date_published: 1994-08-01T00:00:00Z
date_updated: 2022-06-02T09:24:58Z
day: '01'
doi: 10.1006/inco.1994.1060
extern: '1'
intvolume: ' 112'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0890540184710601?via%3Dihub
month: '08'
oa: 1
oa_version: None
page: 273 - 337
publication: Information and Computation
publication_identifier:
issn:
- 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '227'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Temporal proof methodologies for timed transition systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 112
year: '1994'
...
---
_id: '4503'
abstract:
- lang: eng
text: 'We describe finite-state programs over real-numbered time in a guarded-command
language with real-valued clocks or, equivalently, as finite automata with real-valued
clocks. Model checking answers the question which states of a real-time program
satisfy a branching-time specification (given in an extension of CTL with clock
variables). We develop an algorithm that computes this set of states symbolically
as a fixpoint of a functional on state predicates, without constructing the state
space. For this purpose, we introduce a μ-calculus on computation trees over real-numbered
time. Unfortunately, many standard program properties, such as response for all
nonzeno execution sequences (during which time diverges), cannot be characterized
by fixpoints: we show that the expressiveness of the timed μ-calculus is incomparable
to the expressiveness of timed CTL. Fortunately, this result does not impair the
symbolic verification of "implementable" real-time programs-those whose
safety constraints are machine-closed with respect to diverging time and whose
fairness constraints are restricted to finite upper bounds on clock values. All
timed CTL properties of such programs are shown to be computable as finitely approximable
fixpoints in a simple decidable theory.'
acknowledgement: We thank Peter Kopke for a careful reading.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Xavier
full_name: Nicollin, Xavier
last_name: Nicollin
- first_name: Joseph
full_name: Sifakis, Joseph
last_name: Sifakis
- first_name: Sergio
full_name: Yovine, Sergio
last_name: Yovine
citation:
ama: Henzinger TA, Nicollin X, Sifakis J, Yovine S. Symbolic model checking for
real-time systems. Information and Computation. 1994;111(2):193-244. doi:10.1006/inco.1994.1045
apa: Henzinger, T. A., Nicollin, X., Sifakis, J., & Yovine, S. (1994). Symbolic
model checking for real-time systems. Information and Computation. Elsevier.
https://doi.org/10.1006/inco.1994.1045
chicago: Henzinger, Thomas A, Xavier Nicollin, Joseph Sifakis, and Sergio Yovine.
“Symbolic Model Checking for Real-Time Systems.” Information and Computation.
Elsevier, 1994. https://doi.org/10.1006/inco.1994.1045.
ieee: T. A. Henzinger, X. Nicollin, J. Sifakis, and S. Yovine, “Symbolic model checking
for real-time systems,” Information and Computation, vol. 111, no. 2. Elsevier,
pp. 193–244, 1994.
ista: Henzinger TA, Nicollin X, Sifakis J, Yovine S. 1994. Symbolic model checking
for real-time systems. Information and Computation. 111(2), 193–244.
mla: Henzinger, Thomas A., et al. “Symbolic Model Checking for Real-Time Systems.”
Information and Computation, vol. 111, no. 2, Elsevier, 1994, pp. 193–244,
doi:10.1006/inco.1994.1045.
short: T.A. Henzinger, X. Nicollin, J. Sifakis, S. Yovine, Information and Computation
111 (1994) 193–244.
date_created: 2018-12-11T12:09:11Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-02T09:02:02Z
day: '01'
doi: 10.1006/inco.1994.1045
extern: '1'
intvolume: ' 111'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/S0890540184710455?via%3Dihub
month: '06'
oa_version: None
page: 193 - 244
publication: Information and Computation
publication_identifier:
issn:
- 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '226'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Symbolic model checking for real-time systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 111
year: '1994'
...
---
_id: '2487'
abstract:
- lang: eng
text: Distribution of the mRNA for a metabotropic glutamate receptor, mGluR3, which
is coupled to the inhibitory cAMP cascade, was examined in the central nervous
system of the adult albino rat by in situ hybridization. The hybridization signals
of mGluR3 were detected not only on neuronal cells but also on many glial cells
throughout the brain and spinal cord. In the neuronal cells, prominent expression
of mGluR3 mRNA was seen in the thalamic reticular nucleus. Moderately labeled
neurons were seen in the anterior olfactory nucleus, cerebral neo- and mesocortical
regions, lateral amygdaloid nucleus, ventral part of the basolateral amygdaloid
nucleus, dorsal endopiriform nucleus, supraoptic nucleus, superficial layers of
the superior colliculus, inferior colliculus, interpeduncular nucleus, superior
olivary nuclei, and Golgi cells in the cerebellar cortex. Weakly labeled neurons
were observed in the striatum, nucleus accumbens, ventral pallidum, globus pallidus,
entopeduncular nucleus, lateral hypothalamic area, hypothalamic paraventricular
nucleus, medial habenular nucleus, anterior pretectal nucleus, Barrington's nucleus,
Nucleus O, paragenual nucleus, trigeminal sensory complex, cochlear nuclei, dorsal
motor nucleus of the trigeminal nerve, dorsal cap of the inferior olive, spinal
dorsal horn, and lamina X of the spinal cord. The stellate cells in the cerebellar
cortex, and neurons in the deep cerebellar nuclei were also labeled weakly. The
granule cell layer of the dentate gyrus, as a whole, appeared to be labeled intensely,
but each of the granule cells was labeled only weakly. No significant labeling
was detected in the mitral and tufted cells in the olfactory bulb, hippocampal
pyramidal cells, Purkinje and granule cells in the cerebellar cortex, or somatic
motoneurons. The distribution of mGluR3 mRNA in particular neurons and glial cells
indicates specific roles of mGluR3 in the glutamatergic system of the central
nervous system.
acknowledgement: We are grateful for the photographic help of Mr. Akira Uesugi and
the support of Drs. Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Mizuho Katsurada,
Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda, Hiroshi Matsubara, Hiroshi Matsushima,
Chisato Minakuchi, Masatoshi Nishio, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi,
Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watan- abe, Kazuo Yoshino,
and Toshiaki Yoshino. This work was supported in part by grants-in-aid from the
Ministry of Education, Science, and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for
a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization
study. Journal of Comparative Neurology. 1993;335(2):252-266. doi:10.1002/cne.903350209'
apa: 'Ohishi, H., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1993). Distribution
of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An
in situ hybridization study. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.903350209'
chicago: 'Ohishi, Hitoshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno.
“ Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR3) in the
Rat Brain: An in Situ Hybridization Study.” Journal of Comparative Neurology.
Wiley-Blackwell, 1993. https://doi.org/10.1002/cne.903350209.'
ieee: 'H. Ohishi, R. Shigemoto, S. Nakanishi, and N. Mizuno, “ Distribution of the
mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ
hybridization study,” Journal of Comparative Neurology, vol. 335, no. 2.
Wiley-Blackwell, pp. 252–266, 1993.'
ista: 'Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. 1993. Distribution of the
mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ
hybridization study. Journal of Comparative Neurology. 335(2), 252–266.'
mla: 'Ohishi, Hitoshi, et al. “ Distribution of the MRNA for a Metabotropic Glutamate
Receptor (MGluR3) in the Rat Brain: An in Situ Hybridization Study.” Journal
of Comparative Neurology, vol. 335, no. 2, Wiley-Blackwell, 1993, pp. 252–66,
doi:10.1002/cne.903350209.'
short: H. Ohishi, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative
Neurology 335 (1993) 252–266.
date_created: 2018-12-11T11:57:57Z
date_published: 1993-09-08T00:00:00Z
date_updated: 2022-06-01T11:58:11Z
day: '08'
doi: 10.1002/cne.903350209
extern: '1'
external_id:
pmid:
- '8227517'
intvolume: ' 335'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903350209
month: '09'
oa_version: None
page: 252 - 266
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4414'
quality_controlled: '1'
status: public
title: ' Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in
the rat brain: An in situ hybridization study'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 335
year: '1993'
...
---
_id: '2536'
abstract:
- lang: eng
text: A cDNA clone for a new metabotropic glutamate receptor, termed mGluR6, was
isolated from a rat retinal cDNA library by cross-hybridization with the previously
isolated cDNA clone for a metabotropic glutamate receptor. The cloned mGluR6 subtype
consists of 871 amino acid residues and exhibits a structural architecture common
to the metabotropic receptor family, possessing a large extracellular domain preceding
the seven putative membrane-spanning domains. mGluR6 shows the highest sequence
similarity to mGluR4 among the metabotropic receptor subtypes and inhibits the
forskolin- stimulated cyclic AMP accumulation in Chinese hamster ovary cells transfected
with the cloned cDNA. mGluR6 potently reacts with L-2-amino-4- phosphonobutyrate
(L-AP4) and L-serine-O-phosphate, and the potencies of these compounds are one
order of magnitude greater than that of L-glutamate. Blot and in situ hybridization
analyses indicated that mGluR6 mRNA is restrictedly expressed in the inner nuclear
layer of the retina where ON- bipolar cells are distributed. The metabotropic
receptor that responds strongly to L-AP4 and L-serine-O-phosphate in ON-bipolar
cells is known to mediate glutamate synaptic transmission between photoreceptor
cells and ON- bipolar cells. On the basis of the agonist selectivity of mGluR6
and its specific expression in retinal cells, the physiological role of this receptor
subtype in the visual system is discussed.
acknowledgement: "This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan, the Ministry of Health and Welfare,
the Yamanouchi Foundation for Research on Metabolic Disorders, the Uehara Memorial
Foundation, and the Inamori Foundation. The costs of publication of this article
were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely
to indicate this fact. \r\n\r\nWe are grateful to Akira Uesugi for photographic
assistance."
article_processing_charge: No
article_type: original
author:
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Hideki
full_name: Iwakabe, Hideki
last_name: Iwakabe
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Hiroyuki
full_name: Nawa, Hiroyuki
last_name: Nawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Nakajima Y, Iwakabe H, Akazawa C, et al. Molecular characterization of a novel
retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity
for L-2-amino-4- phosphonobutyrate. Journal of Biological Chemistry. 1993;268(16):11868-11873.
doi:10.1016/S0021-9258(19)50280-0
apa: Nakajima, Y., Iwakabe, H., Akazawa, C., Nawa, H., Shigemoto, R., Mizuno, N.,
& Nakanishi, S. (1993). Molecular characterization of a novel retinal metabotropic
glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate.
Journal of Biological Chemistry. American Society for Biochemistry and
Molecular Biology. https://doi.org/10.1016/S0021-9258(19)50280-0
chicago: Nakajima, Yoshiaki, Hideki Iwakabe, Chihiro Akazawa, Hiroyuki Nawa, Ryuichi
Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization
of a Novel Retinal Metabotropic Glutamate Receptor MGluR6 with a High Agonist
Selectivity for L-2-Amino-4- Phosphonobutyrate.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 1993. https://doi.org/10.1016/S0021-9258(19)50280-0.
ieee: Y. Nakajima et al., “Molecular characterization of a novel retinal
metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-
phosphonobutyrate,” Journal of Biological Chemistry, vol. 268, no. 16.
American Society for Biochemistry and Molecular Biology, pp. 11868–11873, 1993.
ista: Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, Nakanishi
S. 1993. Molecular characterization of a novel retinal metabotropic glutamate
receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate.
Journal of Biological Chemistry. 268(16), 11868–11873.
mla: Nakajima, Yoshiaki, et al. “Molecular Characterization of a Novel Retinal Metabotropic
Glutamate Receptor MGluR6 with a High Agonist Selectivity for L-2-Amino-4- Phosphonobutyrate.”
Journal of Biological Chemistry, vol. 268, no. 16, American Society for
Biochemistry and Molecular Biology, 1993, pp. 11868–73, doi:10.1016/S0021-9258(19)50280-0.
short: Y. Nakajima, H. Iwakabe, C. Akazawa, H. Nawa, R. Shigemoto, N. Mizuno, S.
Nakanishi, Journal of Biological Chemistry 268 (1993) 11868–11873.
date_created: 2018-12-11T11:58:15Z
date_published: 1993-06-05T00:00:00Z
date_updated: 2022-04-26T06:56:15Z
day: '05'
doi: 10.1016/S0021-9258(19)50280-0
extern: '1'
external_id:
pmid:
- '8389366'
intvolume: ' 268'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0021-9258(19)50280-0
month: '06'
oa: 1
oa_version: Published Version
page: 11868 - 11873
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4362'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a novel retinal metabotropic glutamate receptor
mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 268
year: '1993'
...
---
_id: '2537'
abstract:
- lang: eng
text: 'The metabotropic glutamate receptors are coupled to intracellular signal
transduction via G-proteins and consist of a family of at least five different
subtypes, termed mGluR1-mGluR5. We studied the signal transduction mechanism and
pharmacological characteristics of the rat mGluR3 and mGluR4 subtypes in Chinese
hamster ovary cells permanently expressing the cloned receptors. Both mGluR3 and
mGluR4 inhibit the forskolin-stimulated accumulation of intracellular cAMP formation
in response to agonist interaction. Consistent with the high degree of sequence
similarity to mGluR2, mGluR3 closely resembles mGluR2 in its agonist selectivity;
the potency rank order of agonists is L-glutamate > trans-1-aminocyclopentane-
1,3-dicarboxylate > ibotenate > quisqualate. mGluR4 is totally different
in its agonist specificity from any other member of the metabotropic receptors.
This receptor potently reacts with L-2-amino-4-phosphonobutyrate(L-AP4) in a stereo-selective
manner and moderately responds to L-serine-O-phosphate. mGluR4 thus corresponds
well to the putative L-AP4 receptor characterized from brain preparations. Blot
and in situ hybridization analyses indicated that both mRNAs are widely distributed
in the rat brain. mGluR3 mRNA is highly expressed in neuronal cells of the cerebral
cortex and the caudate- putamen, and in granule cells of the hippocampal dentate
gyrus. The expression pattern of mGluR4 mRNA is more restricted, and this expression
is prominent in the cerebellum, olfactory bulb, and thalamus. Furthermore, the
mGluR3 mRNA, unlike the other mRNAs for the metabotropic receptors, is highly
expressed in glial cells throughout the brain regions. The metabotropic glutamate
receptor subtypes can thus be classified into three subgroups according to the
similarity in their amino acid sequences, signal transduction, and agonist selectivity:
mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4. The mRNAs for the individual receptor
subtypes, however, show overlapping but distinct patterns of expression in the
rat CNS.'
acknowledgement: 'We are grateful to Mr. Akira Uesugi for photographic assistance.
This work was supported in part by research grants from the Ministry of Education,
Science and Culture of Japan, the Ministry of Health and Welfare of Japan, the Uehara
Memorial Foundation, and the Semi Life Science Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Yasuto
full_name: Tanabe, Yasuto
last_name: Tanabe
- first_name: Akinori
full_name: Nomura, Akinori
last_name: Nomura
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. Signal transduction,
pharmacological properties, and expression patterns of two rat metabotropic glutamate
receptors, mGluR3 and mGluR4. Journal of Neuroscience. 1993;13(4):1372-1378.
doi:10.1523/JNEUROSCI.13-04-01372.1993
apa: Tanabe, Y., Nomura, A., Masu, M., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1993). Signal transduction, pharmacological properties, and expression patterns
of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993
chicago: Tanabe, Yasuto, Akinori Nomura, Masayuki Masu, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Signal Transduction, Pharmacological Properties,
and Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and
MGluR4.” Journal of Neuroscience. Society for Neuroscience, 1993. https://doi.org/10.1523/JNEUROSCI.13-04-01372.1993.
ieee: Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, and S. Nakanishi,
“Signal transduction, pharmacological properties, and expression patterns of two
rat metabotropic glutamate receptors, mGluR3 and mGluR4,” Journal of Neuroscience,
vol. 13, no. 4. Society for Neuroscience, pp. 1372–1378, 1993.
ista: Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S. 1993. Signal
transduction, pharmacological properties, and expression patterns of two rat metabotropic
glutamate receptors, mGluR3 and mGluR4. Journal of Neuroscience. 13(4), 1372–1378.
mla: Tanabe, Yasuto, et al. “Signal Transduction, Pharmacological Properties, and
Expression Patterns of Two Rat Metabotropic Glutamate Receptors, MGluR3 and MGluR4.”
Journal of Neuroscience, vol. 13, no. 4, Society for Neuroscience, 1993,
pp. 1372–78, doi:10.1523/JNEUROSCI.13-04-01372.1993.
short: Y. Tanabe, A. Nomura, M. Masu, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Neuroscience 13 (1993) 1372–1378.
date_created: 2018-12-11T11:58:15Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-31T14:49:42Z
day: '01'
doi: 10.1523/JNEUROSCI.13-04-01372.1993
extern: '1'
external_id:
pmid:
- '8463825'
intvolume: ' 13'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/8463825/
month: '04'
oa: 1
oa_version: Published Version
page: 1372 - 1378
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4361'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Signal transduction, pharmacological properties, and expression patterns of
two rat metabotropic glutamate receptors, mGluR3 and mGluR4
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1993'
...
---
_id: '2538'
abstract:
- lang: eng
text: Rat mRNAs encoding two subtypes of the endothelin (ET) receptor (ET(A) and
ET(B)) were studied in the rat ovary and fallopian tube by means of Northern blotting
and in situ hybridization. The mRNA transcripts for the endothelin- 1-specific
type receptor (ET(A)) in pooled RNA from the ovary and fallopian tube were 4.2
and 5.2 kilonucleotides, and that for the nonselective type receptor (ET(B)) was
4.7 kilonucleotides; these were similar to transcripts for endothelin receptors
from other tissues. ET(A) mRNA expression was abundant in the muscle cell layer
of the fallopian tube, but low in the ovary. On the other hand, ET(B) mRNA was
abundant in the granulosa cells in the developing follicles, but low in atretic
follicles and absent in the fallopian tube. These results demonstrated that the
mRNAs for the two subtypes of the rat endothelin receptor have different expression
profiles in the ovary and fallopian tube. ETs may mainly affect the granulosa
cells in the dominant follicles as well as the muscle cells of the fallopian tube
through ET(B) and ET(A), respectively.
acknowledgement: We thank Ms. Fumiko Kosaka for her excellent technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Masazumi
full_name: Iwai, Masazumi
last_name: Iwai
- first_name: Seiji
full_name: Hori, Seiji
last_name: Hori
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hideharu
full_name: Kanzaki, Hideharu
last_name: Kanzaki
- first_name: Takahide
full_name: Mori, Takahide
last_name: Mori
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. Localization of
endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization. Biology of Reproduction. 1993;49(4):675-680.
doi:10.1095/biolreprod49.4.675
apa: Iwai, M., Hori, S., Shigemoto, R., Kanzaki, H., Mori, T., & Nakanishi,
S. (1993). Localization of endothelin receptor messenger ribonucleic acid in the
rat ovary and fallopian tube by in situ hybridization. Biology of Reproduction.
Society for the Study of Reproduction. https://doi.org/10.1095/biolreprod49.4.675
chicago: Iwai, Masazumi, Seiji Hori, Ryuichi Shigemoto, Hideharu Kanzaki, Takahide
Mori, and Shigetada Nakanishi. “Localization of Endothelin Receptor Messenger
Ribonucleic Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.”
Biology of Reproduction. Society for the Study of Reproduction, 1993. https://doi.org/10.1095/biolreprod49.4.675.
ieee: M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, and S. Nakanishi, “Localization
of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization,” Biology of Reproduction, vol. 49, no. 4.
Society for the Study of Reproduction, pp. 675–680, 1993.
ista: Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. 1993. Localization
of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization. Biology of Reproduction. 49(4), 675–680.
mla: Iwai, Masazumi, et al. “Localization of Endothelin Receptor Messenger Ribonucleic
Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.” Biology
of Reproduction, vol. 49, no. 4, Society for the Study of Reproduction, 1993,
pp. 675–80, doi:10.1095/biolreprod49.4.675.
short: M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, S. Nakanishi, Biology
of Reproduction 49 (1993) 675–680.
date_created: 2018-12-11T11:58:16Z
date_published: 1993-10-01T00:00:00Z
date_updated: 2022-03-31T12:32:51Z
day: '01'
doi: 10.1095/biolreprod49.4.675
extern: '1'
external_id:
pmid:
- '8218631'
intvolume: ' 49'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/biolreprod/article/49/4/675/2762375?login=true
month: '10'
oa: 1
oa_version: Published Version
page: 675 - 680
pmid: 1
publication: Biology of Reproduction
publication_identifier:
issn:
- 0006-3363
publication_status: published
publisher: Society for the Study of Reproduction
publist_id: '4359'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of endothelin receptor messenger ribonucleic acid in the rat ovary
and fallopian tube by in situ hybridization
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1993'
...
---
_id: '2539'
abstract:
- lang: eng
text: cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits
(NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by
molecular screening of a rat brain cDNA library. These subunits are only about
15% identical with the key subunit of the NMDA receptor (NMDAR1) but are highly
homologous (~50% homology) with one another. They also commonly possess large
hydrophilic domains at both amino- and carboxyl- terminal sides of the four putative
transmembrane segments. NMDAR2A and NMDAR2C expressed individually in Xenopus
oocytes showed no electrophysiological response to agonists. However, these subunits
in combined expression with NMDAR1 markedly potentiated the NMDAR1 activity and
produced functional variability in the affinity of agonists, the effectiveness
of antagonists, and the sensitivity to Mg2+ blockade. Thus, NMDAR1 is essential
for the function of the NMDA receptor, and multiple NMDAR2 subunits potentiate
and differentiate the function of the NMDA receptor by forming different heteromeric
configurations with NMDAR1. Northern blotting and in situ hybridization analyses
revealed that the expressions of individual mRNAs for the NMDAR2 subunits overlap
in some brain regions but are also specialized in many other regions. This investigation
demonstrates the anatomical and functional differences of the NMDAR2 subunits,
which provide the molecular basis for the functional diversity of the NMDA receptor.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science, and Culture of Japan, the Ministry of Health and Welfare
of Japan, the Senri Life Science Foundation, and Yamanouchi Foundation for Research
on Metabolic Disorders. The costs of publication of this article were defrayed in
part by the payment of page charges. This article must therefore be hereby marked
“aduertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this
fact.
article_processing_charge: No
article_type: original
author:
- first_name: Takahiro
full_name: Ishii, Takahiro
last_name: Ishii
- first_name: Koki
full_name: Moriyoshi, Koki
last_name: Moriyoshi
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Kazuhir
full_name: Sakurada, Kazuhir
last_name: Sakurada
- first_name: Hiroshi
full_name: Kadotani, Hiroshi
last_name: Kadotani
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Ishii T, Moriyoshi K, Sugihara H, et al. Molecular characterization of the
family of the N-methyl-D-aspartate receptor subunits. Journal of Biological
Chemistry. 1993;268(4):2836-2843. doi:10.1016/s0021-9258(18)53849-7
apa: Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi,
M., … Nakanishi, S. (1993). Molecular characterization of the family of the N-methyl-D-aspartate
receptor subunits. Journal of Biological Chemistry. American Society for
Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(18)53849-7
chicago: Ishii, Takahiro, Koki Moriyoshi, Hidemitsu Sugihara, Kazuhir Sakurada,
Hiroshi Kadotani, Mineto Yokoi, Chihiro Akazawa, et al. “Molecular Characterization
of the Family of the N-Methyl-D-Aspartate Receptor Subunits.” Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology, 1993.
https://doi.org/10.1016/s0021-9258(18)53849-7
.
ieee: T. Ishii et al., “Molecular characterization of the family of the N-methyl-D-aspartate
receptor subunits,” Journal of Biological Chemistry, vol. 268, no. 4. American
Society for Biochemistry and Molecular Biology, pp. 2836–2843, 1993.
ista: Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa
C, Shigemoto R, Mizuno N, Masu M, Nakanishi S. 1993. Molecular characterization
of the family of the N-methyl-D-aspartate receptor subunits. Journal of Biological
Chemistry. 268(4), 2836–2843.
mla: Ishii, Takahiro, et al. “Molecular Characterization of the Family of the N-Methyl-D-Aspartate
Receptor Subunits.” Journal of Biological Chemistry, vol. 268, no. 4, American
Society for Biochemistry and Molecular Biology, 1993, pp. 2836–43, doi:10.1016/s0021-9258(18)53849-7 .
short: T. Ishii, K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi,
C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, S. Nakanishi, Journal of Biological
Chemistry 268 (1993) 2836–2843.
date_created: 2018-12-11T11:58:16Z
date_published: 1993-02-05T00:00:00Z
date_updated: 2022-03-31T14:29:17Z
day: '05'
doi: '10.1016/s0021-9258(18)53849-7 '
extern: '1'
external_id:
pmid:
- '8428958'
intvolume: ' 268'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.jbc.org/article/S0021-9258(18)53849-7/fulltext
month: '02'
oa: 1
oa_version: Published Version
page: 2836 - 2843
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4360'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of the family of the N-methyl-D-aspartate receptor
subunits
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 268
year: '1993'
...
---
_id: '2540'
abstract:
- lang: eng
text: Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2,
which is coupled to the inhibitory cyclic AMP cascade, was investigated in the
central nervous system of the adult rat by in situ hybridization. Transcripts
of mGluR2 were specifically localized to neuronal cells of the brain. Although
the hybridization signals were widely distributed in the brain, the most prominent
expression of mGluR2 messenger RNA was seen in Golgi cells of the cerebellum.
Marked expression of mGluR2 messenger RNA was further observed in the mitral cells
of the accessory olfactory bulb, neurons in the external part of the anterior
olfactory nucleus, and pyramidal neurons in the entorhinal and parasubicular cortical
regions. The granule cells of the accessory olfactory bulb, and many pyramidal
and non-pyramidal neurons in the neocortical, cingulate, retrosplenial and subicular
cortices, were moderately labeled. All of the granule cells in the dentate gyrus
were also labeled moderately, whereas no significant hybridization signals were
detected in Ammon's horn. In the basal forebrain regions, moderately labeled neurons
were distributed in the triangular septal nucleus, in the lateral, basolateral
and basomedial amygdaloid nuclei, and in the medial mammillary nucleus. Weakly
labeled neurons were sparsely scattered in the striatum, globus pallidus, ventral
pallidum and claustrum. The subthalamic nucleus was also labeled weakly. No significant
labeling was found in the entopeduncular nucleus and substantia nigra. In the
thalamus, moderately labeled neurons were distributed in the anterodorsal, anteromedial,
ventromedial, intralaminar and midline nuclei; the ventrolateral part of the anteroventral
nucleus and the rostral pole of the ventrolateral nucleus also contained moderately
labeled neurons. No significant labeling was found in the thalamic reticular,
submedius, ventroposterior, lateral geniculate and medial geniculate nuclei. In
the lower brainstem, labeling was generally weak. No significant hybridization
signals were found in the spinal cord. Some neurons in the inner part of the inner
nuclear layer of the retina and some retinal ganglion cells were labeled moderately.
The pattern of distribution of mGluR2 messenger RNA revealed in the present study
indicates specific roles of mGluR2 in the glutamatergic system in the brain.
acknowledgement: We are grateful for the photographic help of Mr Akira Uesugi and
the support of Drs Ryosuke Fujimori, Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi,
Sozaburo Hayashi, Mizuho Katsurada, Yutaka Kitani, Keiko Kumagai, Hiroshi Kuroda,
Toshio Kuroda, Hiroshi Matsubara. Hiroshi Matsushima. Chisato Minakuchi. Masatoshi
‘Nishio, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Seiichi Ohbayashi, Hiroyasu
Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino and Toshiaki Yoshino. This
work was supported in part by Grants-in-Aid from the Ministry of Education, Science
and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. Distribution of the messenger
RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system
of the rat. Neuroscience. 1993;53(4):1009-1018. doi:10.1016/0306-4522(93)90485-X
apa: Ohishi, H., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1993). Distribution
of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central
nervous system of the rat. Neuroscience. Elsevier. https://doi.org/10.1016/0306-4522(93)90485-X
chicago: Ohishi, Hitoshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno.
“Distribution of the Messenger RNA for a Metabotropic Glutamate Receptor, MGluR2,
in the Central Nervous System of the Rat.” Neuroscience. Elsevier, 1993.
https://doi.org/10.1016/0306-4522(93)90485-X.
ieee: H. Ohishi, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the
messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous
system of the rat,” Neuroscience, vol. 53, no. 4. Elsevier, pp. 1009–1018,
1993.
ista: Ohishi H, Shigemoto R, Nakanishi S, Mizuno N. 1993. Distribution of the messenger
RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system
of the rat. Neuroscience. 53(4), 1009–1018.
mla: Ohishi, Hitoshi, et al. “Distribution of the Messenger RNA for a Metabotropic
Glutamate Receptor, MGluR2, in the Central Nervous System of the Rat.” Neuroscience,
vol. 53, no. 4, Elsevier, 1993, pp. 1009–18, doi:10.1016/0306-4522(93)90485-X.
short: H. Ohishi, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience 53 (1993)
1009–1018.
date_created: 2018-12-11T11:58:16Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-31T12:19:44Z
day: '01'
doi: 10.1016/0306-4522(93)90485-X
extern: '1'
external_id:
pmid:
- '8389425'
intvolume: ' 53'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030645229390485X?via%3Dihub
month: '01'
oa_version: None
page: 1009 - 1018
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4358'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2,
in the central nervous system of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 53
year: '1993'
...
---
_id: '2541'
abstract:
- lang: eng
text: A trp E fusion protein containing a C-terminal portion of the rat substance
P receptor (SPR) was expressed in bacteria and used to produce an antibody. The
antibody specifically reacted with SPR expressed in a mammalian cell line and
rat striatum. Light and electron microscope analyses of the rat striatum revealed
intense SPR-like immunoreactivity in neuronal somata and dendrites. These immunoreactive
neurons constituted ∼ 3% of the total population of striatal neurons; they were
putative interneurons of large and medium-sized aspiny types.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Nakaya, Yoshifumi
last_name: Nakaya
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Nakaya Y, Nomura S, et al. Immunocytochemical localization of
rat substance P receptor in the striatum. Neuroscience Letters. 1993;153(2):157-160.
doi:10.1016/0304-3940(93)90311-8
apa: Shigemoto, R., Nakaya, Y., Nomura, S., Ogawa Meguro, R., Ohishi, H., Kaneko,
T., … Mizuno, N. (1993). Immunocytochemical localization of rat substance P receptor
in the striatum. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(93)90311-8
chicago: Shigemoto, Ryuichi, Yoshifumi Nakaya, Sakashi Nomura, Reiko Ogawa Meguro,
Hitoshi Ohishi, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunocytochemical
Localization of Rat Substance P Receptor in the Striatum.” Neuroscience Letters.
Elsevier, 1993. https://doi.org/10.1016/0304-3940(93)90311-8.
ieee: R. Shigemoto et al., “Immunocytochemical localization of rat substance
P receptor in the striatum,” Neuroscience Letters, vol. 153, no. 2. Elsevier,
pp. 157–160, 1993.
ista: Shigemoto R, Nakaya Y, Nomura S, Ogawa Meguro R, Ohishi H, Kaneko T, Nakanishi
S, Mizuno N. 1993. Immunocytochemical localization of rat substance P receptor
in the striatum. Neuroscience Letters. 153(2), 157–160.
mla: Shigemoto, Ryuichi, et al. “Immunocytochemical Localization of Rat Substance
P Receptor in the Striatum.” Neuroscience Letters, vol. 153, no. 2, Elsevier,
1993, pp. 157–60, doi:10.1016/0304-3940(93)90311-8.
short: R. Shigemoto, Y. Nakaya, S. Nomura, R. Ogawa Meguro, H. Ohishi, T. Kaneko,
S. Nakanishi, N. Mizuno, Neuroscience Letters 153 (1993) 157–160.
date_created: 2018-12-11T11:58:17Z
date_published: 1993-04-30T00:00:00Z
date_updated: 2022-03-31T12:10:05Z
day: '30'
doi: 10.1016/0304-3940(93)90311-8
extern: '1'
external_id:
pmid:
- '8392153 '
intvolume: ' 153'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394093903118?via%3Dihub
month: '04'
oa_version: None
page: 157 - 160
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4357'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of rat substance P receptor in the striatum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 153
year: '1993'
...
---
_id: '2542'
abstract:
- lang: eng
text: A trpE-fusion protein containing a C-terminal sequence of a rat metabotropic
glutamate receptor, mGluR5, was used to produce an antibody. On immunoblot, the
antibody specifically reacted with mGluR5 expressed in mammalian cells and rat
brain. Immunohistochemical analysis revealed intense mGluR5-like immunoreactivity
(LI) in the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, cerebral
cortex, hippocampus, lateral septum, striatum, nucleus accumbens, inferior colliculus,
and spinal trigeminal nuclei. The distribution pattern of mGluR5-LI corresponds
very well with that of mGluR5 mRNA. Electron microscope analysis of the striatum
revealed dense accumulation of immunoreaction products in dendrites which were
often provided with asymmetrical synapses. These results suggest that mGluR5 is
predominantly located in postsynaptic elements.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. Immunohistochemical
localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neuroscience
Letters. 1993;163(1):53-57. doi:10.1016/0304-3940(93)90227-C
apa: Shigemoto, R., Nomura, S., Ohishi, H., Sugihara, H., Nakanishi, S., & Mizuno,
N. (1993). Immunohistochemical localization of a metabotropic glutamate receptor,
mGluR5, in the rat brain. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(93)90227-C
chicago: Shigemoto, Ryuichi, Sakashi Nomura, Hitoshi Ohishi, Hidemitsu Sugihara,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a
Metabotropic Glutamate Receptor, MGluR5, in the Rat Brain.” Neuroscience Letters.
Elsevier, 1993. https://doi.org/10.1016/0304-3940(93)90227-C.
ieee: R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, and N. Mizuno,
“Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain,” Neuroscience Letters, vol. 163, no. 1. Elsevier, pp.
53–57, 1993.
ista: Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N. 1993.
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain. Neuroscience Letters. 163(1), 53–57.
mla: Shigemoto, Ryuichi, et al. “Immunohistochemical Localization of a Metabotropic
Glutamate Receptor, MGluR5, in the Rat Brain.” Neuroscience Letters, vol.
163, no. 1, Elsevier, 1993, pp. 53–57, doi:10.1016/0304-3940(93)90227-C.
short: R. Shigemoto, S. Nomura, H. Ohishi, H. Sugihara, S. Nakanishi, N. Mizuno,
Neuroscience Letters 163 (1993) 53–57.
date_created: 2018-12-11T11:58:17Z
date_published: 1993-11-26T00:00:00Z
date_updated: 2022-03-31T10:21:52Z
day: '26'
doi: 10.1016/0304-3940(93)90227-C
extern: '1'
external_id:
pmid:
- '8295733'
intvolume: ' 163'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439409390227C?via%3Dihub
month: '11'
oa_version: None
page: 53 - 57
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4356'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5,
in the rat brain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 163
year: '1993'
...
---
_id: '2543'
abstract:
- lang: eng
text: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a polypeptide
hormone related to vasoactive intestinal polypeptide (VIP). Rat PACAP receptor
cDNA was isolated from a brain cDNA library by cross-hybridization with rat VIP
receptor cDNA. The recombinant PACAP receptor expressed in COS cells bound PACAP
with about 1000 times higher affinity than VIP, and PACAP stimulated adenylate
cyclase through the cloned PACAP receptor. The rat PACAP receptor consists of
495 amino acids, contains seven transmembrane segments, and has a significant
similarity with other Gs-coupled receptors, such as VIP, glucagon, and secretin
receptors. PACAP receptor mRNA was abundantly expressed in the brain, but not
in the peripheral tissues except for the adrenal gland. In situ hybridization
revealed a high level of expression of PACAP receptor mRNA in the hippocampal
dentate gyrus, olfactory bulb, and cerebellar cortex.
acknowledgement: We are grateful to Drs. Y. Sugimoto, A. Ichikawa, J. Ogasawara, R.
Fukunaga, H. Aino, and A. Baba for discussion and advice. We also thank Ms. K. Mimura
for secretarial assistance. This work was supported in part by the Ministry of Education,
Science and Culture of Japan. The costs of publication of this article were defrayed
in part by the payment of page charges. This article must therefore be hereby marked
“advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Hashimoto, Hitoshi
last_name: Hashimoto
- first_name: Takeshi
full_name: Ishihara, Takeshi
last_name: Ishihara
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kensaku
full_name: Mori, Kensaku
last_name: Mori
- first_name: Shigekazu
full_name: Nagata, Shigekazu
last_name: Nagata
citation:
ama: Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. Molecular cloning
and tissue distribution of a receptor for pituitary adenylate cyclase-activating
polypeptide. Neuron. 1993;11(2):333-342. doi:10.1016/0896-6273(93)90188-W
apa: Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., & Nagata, S. (1993). Molecular
cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating
polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(93)90188-W
chicago: Hashimoto, Hitoshi, Takeshi Ishihara, Ryuichi Shigemoto, Kensaku Mori,
and Shigekazu Nagata. “ Molecular Cloning and Tissue Distribution of a Receptor
for Pituitary Adenylate Cyclase-Activating Polypeptide.” Neuron. Elsevier,
1993. https://doi.org/10.1016/0896-6273(93)90188-W.
ieee: H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, and S. Nagata, “ Molecular
cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating
polypeptide,” Neuron, vol. 11, no. 2. Elsevier, pp. 333–342, 1993.
ista: Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. 1993. Molecular cloning
and tissue distribution of a receptor for pituitary adenylate cyclase-activating
polypeptide. Neuron. 11(2), 333–342.
mla: Hashimoto, Hitoshi, et al. “ Molecular Cloning and Tissue Distribution of a
Receptor for Pituitary Adenylate Cyclase-Activating Polypeptide.” Neuron,
vol. 11, no. 2, Elsevier, 1993, pp. 333–42, doi:10.1016/0896-6273(93)90188-W.
short: H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, S. Nagata, Neuron 11 (1993)
333–342.
date_created: 2018-12-11T11:58:17Z
date_published: 1993-08-01T00:00:00Z
date_updated: 2022-03-31T09:56:46Z
day: '01'
doi: 10.1016/0896-6273(93)90188-W
extern: '1'
external_id:
pmid:
- '8394723'
intvolume: ' 11'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/089662739390188W?via%3Dihub
month: '08'
oa_version: None
page: 333 - 342
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4355'
quality_controlled: '1'
scopus_import: '1'
status: public
title: ' Molecular cloning and tissue distribution of a receptor for pituitary adenylate
cyclase-activating polypeptide'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1993'
...
---
_id: '2544'
abstract:
- lang: eng
text: VARIOUS functions of glutamate transmission are mediated by both ionotropic
and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs)
consist of at least six different subtypes that are classified into three subgroups,
mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological
roles are largely unknown. Here we report the identification of a very potent
agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in
granule cell dendrites that form dendrodendritic synapses with mitral cells in
the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination
with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically
suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell.
Our results indicate that mGluR2 in granule cells plays an important role in the
persistent excitation of olfactory sensory transmission in the accessory olfactory
bulb by relieving mitral cells from the GABA inhibition.
acknowledgement: 'We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice
and A. Uesugi for photographic assistance. Partly supported by research grants from
the Ministry of Education, Science and Culture of Japan, the Ministry of Health
and Welfare of Japan and the Senri Life Science Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Yasunori
full_name: Hayashi, Yasunori
last_name: Hayashi
- first_name: Akiko
full_name: Momiyama, Akiko
last_name: Momiyama
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate
receptor in synaptic modulation in the accessory olfactory bulb. Nature.
1993;366(6456):687-690. doi:10.1038/366687a0
apa: Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto,
R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb. Nature. Nature Publishing Group.
https://doi.org/10.1038/366687a0
chicago: Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi,
Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi.
“Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory
Olfactory Bulb.” Nature. Nature Publishing Group, 1993. https://doi.org/10.1038/366687a0.
ieee: Y. Hayashi et al., “Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb,” Nature, vol. 366, no. 6456.
Nature Publishing Group, pp. 687–690, 1993.
ista: Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R,
Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic
modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690.
mla: Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic
Modulation in the Accessory Olfactory Bulb.” Nature, vol. 366, no. 6456,
Nature Publishing Group, 1993, pp. 687–90, doi:10.1038/366687a0.
short: Y. Hayashi, A. Momiyama, T. Takahashi, H. Ohishi, R. Ogawa Meguro, R. Shigemoto,
N. Mizuno, S. Nakanishi, Nature 366 (1993) 687–690.
date_created: 2018-12-11T11:58:18Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-31T09:36:00Z
day: '01'
doi: 10.1038/366687a0
extern: '1'
external_id:
pmid:
- '7903116 '
intvolume: ' 366'
issue: '6456'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/366687a0
month: '01'
oa_version: None
page: 687 - 690
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '4354'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Role of a metabotropic glutamate receptor in synaptic modulation in the accessory
olfactory bulb
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 366
year: '1993'
...