---
_id: '2563'
abstract:
- lang: eng
text: By means of substance P receptor (SPR) immunofluorescence histochemistry combined
with Fluoro-Gold fluorescent retrograde labeling, SPR-like immunoreactive neurons
in the caudal subnucleus of the spinal trigeminal nucleus of the rat were observed
to send their axons to the nucleus of Kolliker-Fuse and ventrolateral part of
the lateral parabrachial nucleus bilaterally with a clear ipsilateral dominance.
These neurons were distributed mainly in lamina I, and additionally in lamina
III.
acknowledgement: 'The authors are grateful for photographic help of Ms. Miao-Li Zhang
and Mr. Akira Uesugi. This work was supported in part by Grants-in-Aid for Special
Research on Priority Areas 05267104, Scientific Research (B) 05454658, and Scientific
Research (C) 06680735 from the Ministry of Education, Science and Culture of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Takada M, Shigemoto R, Mizuno N. Trigeminoparabrachial projection neurons
showing substance P receptor-like immunoreactivity in the rat. Neuroscience
Research. 1995;23(4):415-418. doi:10.1016/0168-0102(95)00961-R
apa: Ding, Y., Takada, M., Shigemoto, R., & Mizuno, N. (1995). Trigeminoparabrachial
projection neurons showing substance P receptor-like immunoreactivity in the rat.
Neuroscience Research. Elsevier. https://doi.org/10.1016/0168-0102(95)00961-R
chicago: Ding, Yu, Masahiko Takada, Ryuichi Shigemoto, and Noboru Mizuno. “Trigeminoparabrachial
Projection Neurons Showing Substance P Receptor-like Immunoreactivity in the Rat.”
Neuroscience Research. Elsevier, 1995. https://doi.org/10.1016/0168-0102(95)00961-R.
ieee: Y. Ding, M. Takada, R. Shigemoto, and N. Mizuno, “Trigeminoparabrachial projection
neurons showing substance P receptor-like immunoreactivity in the rat,” Neuroscience
Research, vol. 23, no. 4. Elsevier, pp. 415–418, 1995.
ista: Ding Y, Takada M, Shigemoto R, Mizuno N. 1995. Trigeminoparabrachial projection
neurons showing substance P receptor-like immunoreactivity in the rat. Neuroscience
Research. 23(4), 415–418.
mla: Ding, Yu, et al. “Trigeminoparabrachial Projection Neurons Showing Substance
P Receptor-like Immunoreactivity in the Rat.” Neuroscience Research, vol.
23, no. 4, Elsevier, 1995, pp. 415–18, doi:10.1016/0168-0102(95)00961-R.
short: Y. Ding, M. Takada, R. Shigemoto, N. Mizuno, Neuroscience Research 23 (1995)
415–418.
date_created: 2018-12-11T11:58:24Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2022-06-28T09:50:42Z
day: '01'
doi: 10.1016/0168-0102(95)00961-R
extern: '1'
external_id:
pmid:
- '8602281'
intvolume: ' 23'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/016801029500961R?via%3Dihub
month: '11'
oa_version: None
page: 415 - 418
pmid: 1
publication: Neuroscience Research
publication_identifier:
issn:
- 0168-0102
publication_status: published
publisher: Elsevier
publist_id: '4336'
quality_controlled: '1'
status: public
title: Trigeminoparabrachial projection neurons showing substance P receptor-like
immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 23
year: '1995'
...
---
_id: '2712'
abstract:
- lang: eng
text: We study the generalizations of the well-known Lieb-Thirring inequality for
the magnetic Schrödinger operator with a nonconstant magnetic field. We use stochastic
methods to prove estimates on the moments of the negative eigenvalues.
acknowledgement: Work supported by the NSF grant PHY90-19433 A02, by the Alfred Sloan
Foundation dissertation Fellowship and by the Erwin Schrödinger Institute for Mathematical
Physics in Vienna.
alternative_title:
- 'Operator Theory: Advances and Applications'
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Magnetic Lieb-Thirring inequalities and stochastic oscillatory integrals.
In: Vol 78. Birkhäuser; 1995:127-132. doi:10.1007/978-3-0348-9092-2_13'
apa: 'Erdös, L. (1995). Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals (Vol. 78, pp. 127–132). Presented at the International Conference on
Partial Differential Operators and Mathematical Physics, Holzhau, Germany: Birkhäuser.
https://doi.org/10.1007/978-3-0348-9092-2_13'
chicago: Erdös, László. “Magnetic Lieb-Thirring Inequalities and Stochastic Oscillatory
Integrals,” 78:127–32. Birkhäuser, 1995. https://doi.org/10.1007/978-3-0348-9092-2_13.
ieee: L. Erdös, “Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals,” presented at the International Conference on Partial Differential
Operators and Mathematical Physics, Holzhau, Germany, 1995, vol. 78, pp. 127–132.
ista: 'Erdös L. 1995. Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals. International Conference on Partial Differential Operators and Mathematical
Physics, Operator Theory: Advances and Applications, vol. 78, 127–132.'
mla: Erdös, László. Magnetic Lieb-Thirring Inequalities and Stochastic Oscillatory
Integrals. Vol. 78, Birkhäuser, 1995, pp. 127–32, doi:10.1007/978-3-0348-9092-2_13.
short: L. Erdös, in:, Birkhäuser, 1995, pp. 127–132.
conference:
end_date: 1995-07-09
location: Holzhau, Germany
name: International Conference on Partial Differential Operators and Mathematical
Physics
start_date: 1995-07-03
date_created: 2018-12-11T11:59:12Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T09:31:20Z
day: '01'
doi: 10.1007/978-3-0348-9092-2_13
extern: '1'
intvolume: ' 78'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-9092-2_13
month: '01'
oa_version: None
page: 127 - 132
publication_status: published
publisher: Birkhäuser
publist_id: '4184'
quality_controlled: '1'
status: public
title: Magnetic Lieb-Thirring inequalities and stochastic oscillatory integrals
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 78
year: '1995'
...
---
_id: '2724'
abstract:
- lang: eng
text: We study the generalizations of the well-known Lieb-Thirring inequality for
the magnetic Schrödinger operator with nonconstant magnetic field. Our main result
is the naturally expected magnetic Lieb-Thirring estimate on the moments of the
negative eigenvalues for a certain class of magnetic fields (including even some
unbounded ones). We develop a localization technique in path space of the stochastic
Feynman-Kac representation of the heat kernel which effectively estimates the
oscillatory effect due to the magnetic phase factor.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Magnetic Lieb-Thirring inequalities. Communications in Mathematical
Physics. 1995;170(3):629-668. doi:10.1007/BF02099152
apa: Erdös, L. (1995). Magnetic Lieb-Thirring inequalities. Communications in
Mathematical Physics. Springer. https://doi.org/10.1007/BF02099152
chicago: Erdös, László. “Magnetic Lieb-Thirring Inequalities.” Communications
in Mathematical Physics. Springer, 1995. https://doi.org/10.1007/BF02099152.
ieee: L. Erdös, “Magnetic Lieb-Thirring inequalities,” Communications in Mathematical
Physics, vol. 170, no. 3. Springer, pp. 629–668, 1995.
ista: Erdös L. 1995. Magnetic Lieb-Thirring inequalities. Communications in Mathematical
Physics. 170(3), 629–668.
mla: Erdös, László. “Magnetic Lieb-Thirring Inequalities.” Communications in
Mathematical Physics, vol. 170, no. 3, Springer, 1995, pp. 629–68, doi:10.1007/BF02099152.
short: L. Erdös, Communications in Mathematical Physics 170 (1995) 629–668.
date_created: 2018-12-11T11:59:16Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-28T09:19:36Z
day: '01'
doi: 10.1007/BF02099152
extern: '1'
intvolume: ' 170'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02099152
month: '06'
oa_version: None
page: 629 - 668
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4168'
quality_controlled: '1'
status: public
title: Magnetic Lieb-Thirring inequalities
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 170
year: '1995'
...
---
_id: '11677'
abstract:
- lang: eng
text: "We present an algorithm for maintaining the biconnected components of a graph
during a sequence of edge insertions and deletions. It requires linear storage
and preprocessing time. The amortized running time for insertions and for deletions
isO(m 2/3 ), wherem is the number of edges in the graph. Any query of the form
‘Are the verticesu andv biconnected?’ can be answered in timeO(1). This is the
first sublinear algorithm for this problem. We can also output all articulation
points separating any two vertices efficiently.\r\n\r\nIf the input is a plane
graph, the amortized running time for insertions and deletions drops toO(√n logn)
and the query time isO(log2 n), wheren is the number of vertices in the graph.
The best previously known solution takes timeO(n 2/3 ) per update or query."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. Fully dynamic biconnectivity in graphs. Algorithmica.
1995;13(6):503-538. doi:10.1007/bf01189067
apa: Henzinger, M. H. (1995). Fully dynamic biconnectivity in graphs. Algorithmica.
Springer Nature. https://doi.org/10.1007/bf01189067
chicago: Henzinger, Monika H. “Fully Dynamic Biconnectivity in Graphs.” Algorithmica.
Springer Nature, 1995. https://doi.org/10.1007/bf01189067.
ieee: M. H. Henzinger, “Fully dynamic biconnectivity in graphs,” Algorithmica,
vol. 13, no. 6. Springer Nature, pp. 503–538, 1995.
ista: Henzinger MH. 1995. Fully dynamic biconnectivity in graphs. Algorithmica.
13(6), 503–538.
mla: Henzinger, Monika H. “Fully Dynamic Biconnectivity in Graphs.” Algorithmica,
vol. 13, no. 6, Springer Nature, 1995, pp. 503–38, doi:10.1007/bf01189067.
short: M.H. Henzinger, Algorithmica 13 (1995) 503–538.
date_created: 2022-07-27T14:50:46Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-09-12T09:00:14Z
day: '01'
doi: 10.1007/bf01189067
extern: '1'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 503-538
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic biconnectivity in graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '1995'
...
---
_id: '11684'
abstract:
- lang: eng
text: 'This paper presents an algorithm for the fully dynamic biconnectivity problem
whose running time is exponentially faster than all previously known solutions.
It is the first dynamic algorithm that answers biconnectivity queries in time
O(log/sup 2/n) in a n-node graph and can be updated after an edge insertion or
deletion in polylogarithmic time. Our algorithm is a Las-Vegas style randomized
algorithm with the update time amortized update time O(log/sup 4/n). Only recently
the best deterministic result for this problem was improved to O(/spl radic/nlog/sup
2/n). We also give the first fully dynamic and a novel deletions-only transitive
closure (i.e. directed connectivity) algorithms. These are randomized Monte Carlo
algorithms. Let n be the number of nodes in the graph and let m/spl circ/ be the
average number of edges in the graph during the whole update sequence: The fully
dynamic algorithms achieve (1) query time O(n/logn) and update time O(m/spl circ//spl
radic/nlog/sup 2/n+n); or (2) query time O(n/logn) and update time O(nm/spl circ//sup
/spl mu/-1/)log/sup 2/n=O(nm/spl circ//sup 0.58/log/sup 2/n), where /spl mu/ is
the exponent for boolean matrix multiplication (currently /spl mu/=2.38). The
deletions-only algorithm answers queries in time O(n/logn). Its amortized update
time is O(nlog/sup 2/n).'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: V.
full_name: King, V.
last_name: King
citation:
ama: 'Henzinger MH, King V. Fully dynamic biconnectivity and transitive closure.
In: Proceedings of IEEE 36th Annual Foundations of Computer Science. Institute
of Electrical and Electronics Engineers; 1995:664-672. doi:10.1109/SFCS.1995.492668'
apa: 'Henzinger, M. H., & King, V. (1995). Fully dynamic biconnectivity and
transitive closure. In Proceedings of IEEE 36th Annual Foundations of Computer
Science (pp. 664–672). Milwaukee, WI, United States: Institute of Electrical
and Electronics Engineers. https://doi.org/10.1109/SFCS.1995.492668'
chicago: Henzinger, Monika H, and V. King. “Fully Dynamic Biconnectivity and Transitive
Closure.” In Proceedings of IEEE 36th Annual Foundations of Computer Science,
664–72. Institute of Electrical and Electronics Engineers, 1995. https://doi.org/10.1109/SFCS.1995.492668.
ieee: M. H. Henzinger and V. King, “Fully dynamic biconnectivity and transitive
closure,” in Proceedings of IEEE 36th Annual Foundations of Computer Science,
Milwaukee, WI, United States, 1995, pp. 664–672.
ista: Henzinger MH, King V. 1995. Fully dynamic biconnectivity and transitive closure.
Proceedings of IEEE 36th Annual Foundations of Computer Science. Foundations of
Computer Science, 664–672.
mla: Henzinger, Monika H., and V. King. “Fully Dynamic Biconnectivity and Transitive
Closure.” Proceedings of IEEE 36th Annual Foundations of Computer Science,
Institute of Electrical and Electronics Engineers, 1995, pp. 664–72, doi:10.1109/SFCS.1995.492668.
short: M.H. Henzinger, V. King, in:, Proceedings of IEEE 36th Annual Foundations
of Computer Science, Institute of Electrical and Electronics Engineers, 1995,
pp. 664–672.
conference:
end_date: 1995-10-25
location: Milwaukee, WI, United States
name: Foundations of Computer Science
start_date: 1995-10-23
date_created: 2022-07-28T11:28:13Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2023-02-09T11:35:17Z
day: '01'
doi: 10.1109/SFCS.1995.492668
extern: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 664-672
publication: Proceedings of IEEE 36th Annual Foundations of Computer Science
publication_identifier:
isbn:
- 0-8186-7183-1
issn:
- 0272-5428
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic biconnectivity and transitive closure
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1995'
...
---
_id: '11805'
abstract:
- lang: eng
text: In this paper, we present sparse certificates for biconnectivity together
with algorithms for updating these certificates. We thus obtain fully-dynamic
algorithms for biconnectivity in graphs that run in O(√n log n log⌈m/n⌉) amortized
time per operation, where m is the number of edges and n is the number of nodes
in the graph. This improves upon the results in [11], in which algorithms were
presented running in O(√m) amortized time, and solves the open problem to find
certificates to speed up biconnectivity, as stated in [2].
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Han
full_name: Poutré, Han
last_name: Poutré
citation:
ama: 'Henzinger MH, Poutré H. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. In: 3rd Annual European Symposium on Algorithms.
Vol 979. Springer Nature; 1995:171–184. doi:10.1007/3-540-60313-1_142'
apa: 'Henzinger, M. H., & Poutré, H. (1995). Certificates and fast algorithms
for biconnectivity in fully-dynamic graphs. In 3rd Annual European Symposium
on Algorithms (Vol. 979, pp. 171–184). Corfu, Greece: Springer Nature. https://doi.org/10.1007/3-540-60313-1_142'
chicago: Henzinger, Monika H, and Han Poutré. “Certificates and Fast Algorithms
for Biconnectivity in Fully-Dynamic Graphs.” In 3rd Annual European Symposium
on Algorithms, 979:171–184. Springer Nature, 1995. https://doi.org/10.1007/3-540-60313-1_142.
ieee: M. H. Henzinger and H. Poutré, “Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs,” in 3rd Annual European Symposium on Algorithms,
Corfu, Greece, 1995, vol. 979, pp. 171–184.
ista: 'Henzinger MH, Poutré H. 1995. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. 3rd Annual European Symposium on Algorithms. ESA: European
Symposium on Algorithms, LNCS, vol. 979, 171–184.'
mla: Henzinger, Monika H., and Han Poutré. “Certificates and Fast Algorithms for
Biconnectivity in Fully-Dynamic Graphs.” 3rd Annual European Symposium on Algorithms,
vol. 979, Springer Nature, 1995, pp. 171–184, doi:10.1007/3-540-60313-1_142.
short: M.H. Henzinger, H. Poutré, in:, 3rd Annual European Symposium on Algorithms,
Springer Nature, 1995, pp. 171–184.
conference:
end_date: 1995-09-27
location: Corfu, Greece
name: 'ESA: European Symposium on Algorithms'
start_date: 1995-09-25
date_created: 2022-08-11T14:09:52Z
date_published: 1995-09-01T00:00:00Z
date_updated: 2023-02-14T08:02:03Z
day: '01'
doi: 10.1007/3-540-60313-1_142
extern: '1'
intvolume: ' 979'
language:
- iso: eng
month: '09'
oa_version: None
page: 171–184
publication: 3rd Annual European Symposium on Algorithms
publication_identifier:
eisbn:
- '9783540449133'
eissn:
- 1611-3349
isbn:
- '9783540603139'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Certificates and fast algorithms for biconnectivity in fully-dynamic graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 979
year: '1995'
...
---
_id: '11806'
abstract:
- lang: eng
text: This paper presents insertions-only algorithms for maintaining the exact and
approximate size of the minimum edge cut and the minimum vertex cut of a graph.
The algorithms output the approximate or exact size k in time O(1) or O(log n)
and a cut of size k in time linear in its size. The amortized time per insertion
is O(1/ε 2) for a (2+ε)-approximation, O((log λ)((log n)/ε)2) for a (1+ε)-approximation,
and O(λ log n) for the exact size of the minimum edge cut, where n is the number
of nodes in the graph, λ is the size of the minimum cut and ε>0. The (2+ε)-approximation
algorithm and the exact algorithm are deterministic, the (1+ε)-approximation algorithm
is randomized. The algorithms are optimal in the sense that the time needed for
m insertions matches the time needed by the best static algorithm on a m-edge
graph. We also present a static 2-approximation algorithm for the size κ of the
minimum vertex cut in a graph, which takes time O(n 2 min(√n,κ)). This is a factor
of κ faster than the best algorithm for computing the exact size, which takes
time O(κ 2 n 2 +κ 3 n 1.5). We give an insertionsonly algorithm for maintaining
a (2+ε)-approximation of the minimum vertex cut with amortized insertion time
O(n(logκk)/ε).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Approximating minimum cuts under insertions. In: 22nd International
Colloquium on Automata, Languages and Programming. Vol 944. Springer Nature;
1995:280–291. doi:10.1007/3-540-60084-1_81'
apa: 'Henzinger, M. H. (1995). Approximating minimum cuts under insertions. In 22nd
International Colloquium on Automata, Languages and Programming (Vol. 944,
pp. 280–291). Szeged, Hungary: Springer Nature. https://doi.org/10.1007/3-540-60084-1_81'
chicago: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” In
22nd International Colloquium on Automata, Languages and Programming, 944:280–291.
Springer Nature, 1995. https://doi.org/10.1007/3-540-60084-1_81.
ieee: M. H. Henzinger, “Approximating minimum cuts under insertions,” in 22nd
International Colloquium on Automata, Languages and Programming, Szeged, Hungary,
1995, vol. 944, pp. 280–291.
ista: 'Henzinger MH. 1995. Approximating minimum cuts under insertions. 22nd International
Colloquium on Automata, Languages and Programming. ICALP: International Colloquium
on Automata, Languages, and Programming, LNCS, vol. 944, 280–291.'
mla: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” 22nd
International Colloquium on Automata, Languages and Programming, vol. 944,
Springer Nature, 1995, pp. 280–291, doi:10.1007/3-540-60084-1_81.
short: M.H. Henzinger, in:, 22nd International Colloquium on Automata, Languages
and Programming, Springer Nature, 1995, pp. 280–291.
conference:
end_date: 1995-07-14
location: Szeged, Hungary
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 1995-07-10
date_created: 2022-08-11T14:17:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2023-02-14T08:09:08Z
day: '01'
doi: 10.1007/3-540-60084-1_81
extern: '1'
intvolume: ' 944'
language:
- iso: eng
month: '07'
oa_version: None
page: 280–291
publication: 22nd International Colloquium on Automata, Languages and Programming
publication_identifier:
eisbn:
- '9783540600848'
eissn:
- 1611-3349
isbn:
- '9783540494256'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Approximating minimum cuts under insertions
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 944
year: '1995'
...
---
_id: '11928'
abstract:
- lang: eng
text: "We present a model with restricted randomness for edge updates in dynamic
graph algorithms and a general technique\r\nfor analyzing the expected running
time of an update operation. This model is able to capture the average case in
many applications, since (1) it allows restrictions on the set of edges which
can be used for insertions and (2) the type (insertion or deletion) of each update
operation is arbitrary, i.e., not random. We use our technique to analyze existing
and new dynamic algorithms for maximum cardinality matching, minimum spanning
forest, connectivity, 2-edge connectivity,\r\nk-edge connectivity, k-vertex connectivity,
and bipartiteness. Given a random graph G with mo edges and n vertices and\r\na
sequence of 1 update operations such that the graph contains rni edges after operation
i, the expected time for performing the updates for any 1 is O(1 logn + n xi=,
l/fii) in the case of minimum spanning forests, connectivity, 2-\r\nedge connectivity,
and bipartiteness. The expected time per update operation is O(n) in the case
of maximum matching. For k-edge and k-vertex connectivity we also give improved
bounds. Additionally we give an insertions-only algorithm for maximum cardinality
matching with worst-case O(n) amortized time per insertion. "
article_processing_charge: No
author:
- first_name: David
full_name: Alberts, David
last_name: Alberts
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Alberts D, Henzinger MH. Average case analysis of dynamic graph algorithms.
In: 6th Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial
and Applied Mathematics; 1995:312-321.'
apa: 'Alberts, D., & Henzinger, M. H. (1995). Average case analysis of dynamic
graph algorithms. In 6th Annual ACM-SIAM Symposium on Discrete Algorithms
(pp. 312–321). San Francisco, CA, United States: Society for Industrial and Applied
Mathematics.'
chicago: Alberts, David, and Monika H Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” In 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
312–21. Society for Industrial and Applied Mathematics, 1995.
ieee: D. Alberts and M. H. Henzinger, “Average case analysis of dynamic graph algorithms,”
in 6th Annual ACM-SIAM Symposium on Discrete Algorithms, San Francisco,
CA, United States, 1995, pp. 312–321.
ista: 'Alberts D, Henzinger MH. 1995. Average case analysis of dynamic graph algorithms.
6th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete
Algorithms, 312–321.'
mla: Alberts, David, and Monika H. Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
Society for Industrial and Applied Mathematics, 1995, pp. 312–21.
short: D. Alberts, M.H. Henzinger, in:, 6th Annual ACM-SIAM Symposium on Discrete
Algorithms, Society for Industrial and Applied Mathematics, 1995, pp. 312–321.
conference:
end_date: 1995-01-24
location: San Francisco, CA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 1995-01-22
date_created: 2022-08-19T07:10:23Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2023-02-21T16:24:58Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://dl.acm.org/doi/10.5555/313651.313712
month: '01'
oa: 1
oa_version: Published Version
page: 312-321
publication: 6th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '0898713498'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
record:
- id: '11680'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Average case analysis of dynamic graph algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1995'
...
---
_id: '1949'
abstract:
- lang: eng
text: H+-transhydrogenase (H+-Thase) and NADP-linked isocitrate dehydrogenase (NADP-ICDH)
are very active in animal mitochondria but their physiological function is only
poorly understood. This is especially so in the case of the heart and muscle,
where there are no major consumers of NADPH. We propose here that H+-Thase and
NADP-ICDH have a combined function in the fine regulation of the activity of the
tricarboxylic acid (TCA) cycle, providing enhanced sensitivy to changes in energy
demand. This is achieved through cycling of substrates by NAD-linked ICDH, NADP-linked
ICDH and H+-Thase. It is proposed that NAD-ICDH operates in the forward direction
of the TCA cycle, but NADP-ICDH is driven in reverse by elevated levels of NADPH
resulting from the action of the transmembrane proton electrochemical potential
gradient (Δp) on H+-Thase. This has the effect of increasing the sensitivity to
allosteric modifiers of NAD-ICDH (NADH, ADP, ATP, Ca2+ etc), potentially giving
rise to large changes in the net flux from iso-citrate to α-ketoglutarate. Furthermore,
changes in the level of Δp resulting from changes in the demand for ATP would,
via H+-Thase, shift the redox state of the NADP pool and this, in turn, would
lead to a change in the rate of the reaction catalysed by NADP-ICDH and hence
to an additional and complementary effect on the net metabolic flux from isocitrate
to α-ketoglutarate. Other consequences of this substrate cycle are, (i) the production
of heat at the expense of Δp, which may contribute to thermoregulation in the
animal, and (ii) an increased rate of dissipation of Δp (leak).
acknowledgement: LAS is grateful to the Wellcome Trust for a fellowship. We should
like to thank Prof. R.M. Denton for discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
citation:
ama: Sazanov LA, Jackson J. Proton translocating transhydrogenase and NAD- and NADP-linked
isocitrate dehydrogenases operate in a substrate cycle which contributes to fine
regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Letters.
1994;344(2-3):109-116. doi:10.1016/0014-5793(94)00370-X
apa: Sazanov, L. A., & Jackson, J. (1994). Proton translocating transhydrogenase
and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle
which contributes to fine regulation of the tricarboxylic acid cycle activity
in mitochondria. FEBS Letters. Elsevier. https://doi.org/10.1016/0014-5793(94)00370-X
chicago: Sazanov, Leonid A, and Julie Jackson. “Proton Translocating Transhydrogenase
and NAD- and NADP-Linked Isocitrate Dehydrogenases Operate in a Substrate Cycle
Which Contributes to Fine Regulation of the Tricarboxylic Acid Cycle Activity
in Mitochondria.” FEBS Letters. Elsevier, 1994. https://doi.org/10.1016/0014-5793(94)00370-X.
ieee: L. A. Sazanov and J. Jackson, “Proton translocating transhydrogenase and NAD-
and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes
to fine regulation of the tricarboxylic acid cycle activity in mitochondria,”
FEBS Letters, vol. 344, no. 2–3. Elsevier, pp. 109–116, 1994.
ista: Sazanov LA, Jackson J. 1994. Proton translocating transhydrogenase and NAD-
and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes
to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS
Letters. 344(2–3), 109–116.
mla: Sazanov, Leonid A., and Julie Jackson. “Proton Translocating Transhydrogenase
and NAD- and NADP-Linked Isocitrate Dehydrogenases Operate in a Substrate Cycle
Which Contributes to Fine Regulation of the Tricarboxylic Acid Cycle Activity
in Mitochondria.” FEBS Letters, vol. 344, no. 2–3, Elsevier, 1994, pp.
109–16, doi:10.1016/0014-5793(94)00370-X.
short: L.A. Sazanov, J. Jackson, FEBS Letters 344 (1994) 109–116.
date_created: 2018-12-11T11:54:52Z
date_published: 1994-05-16T00:00:00Z
date_updated: 2022-06-09T13:21:50Z
day: '16'
doi: 10.1016/0014-5793(94)00370-X
extern: '1'
external_id:
pmid:
- '8187868'
intvolume: ' 344'
issue: 2-3
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2900370-X
month: '05'
oa: 1
oa_version: Published Version
page: 109 - 116
pmid: 1
publication: FEBS Letters
publication_identifier:
issn:
- 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '5134'
quality_controlled: '1'
status: public
title: Proton translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases
operate in a substrate cycle which contributes to fine regulation of the tricarboxylic
acid cycle activity in mitochondria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 344
year: '1994'
...
---
_id: '1953'
abstract:
- lang: eng
text: The respiratory burst induced by phorbol myristate acetate in mouse macrophages
was inhibited by ultra-low doses (10-15 -10-13 M) of an opioid peptide [d-Ala2]
methionine enkephalinamide. The effect disappeared at concentrations above and
below this range. The inhibition approached 50% and was statistically significant
(P < 0.001). Increasing the time of the opioid incubation with cells brought
about a shift in the maximal effect to lower concentrations of the opioid (from
10-13 to 5 · 10-15 M) and led to a decrease in the value of the effect, fully
in accord with the previously proposed adaptation mechanism of the action of ultra-low
doses.
article_processing_charge: No
article_type: original
author:
- first_name: Alexander
full_name: Efanov, Alexander
last_name: Efanov
- first_name: Aleksei
full_name: Koshkin, Aleksei
last_name: Koshkin
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: O I
full_name: Borodulina, O I
last_name: Borodulina
- first_name: Sergei
full_name: Varfolomeev, Sergei
last_name: Varfolomeev
- first_name: Sergei
full_name: Zaǐtsev, Sergei
last_name: Zaǐtsev
citation:
ama: Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition
of the respiratory burst in mouse macrophages by ultra-low doses of an opioid
peptide is consistent with a possible adaptation mechanism. FEBS Letters.
1994;355(2):114-116. doi:10.1016/0014-5793(94)01109-5
apa: Efanov, A., Koshkin, A., Sazanov, L. A., Borodulina, O. I., Varfolomeev, S.,
& Zaǐtsev, S. (1994). Inhibition of the respiratory burst in mouse macrophages
by ultra-low doses of an opioid peptide is consistent with a possible adaptation
mechanism. FEBS Letters. Elsevier. https://doi.org/10.1016/0014-5793(94)01109-5
chicago: Efanov, Alexander, Aleksei Koshkin, Leonid A Sazanov, O I Borodulina, Sergei
Varfolomeev, and Sergei Zaǐtsev. “Inhibition of the Respiratory Burst in Mouse
Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible
Adaptation Mechanism.” FEBS Letters. Elsevier, 1994. https://doi.org/10.1016/0014-5793(94)01109-5.
ieee: A. Efanov, A. Koshkin, L. A. Sazanov, O. I. Borodulina, S. Varfolomeev, and
S. Zaǐtsev, “Inhibition of the respiratory burst in mouse macrophages by ultra-low
doses of an opioid peptide is consistent with a possible adaptation mechanism,”
FEBS Letters, vol. 355, no. 2. Elsevier, pp. 114–116, 1994.
ista: Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S.
1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses
of an opioid peptide is consistent with a possible adaptation mechanism. FEBS
Letters. 355(2), 114–116.
mla: Efanov, Alexander, et al. “Inhibition of the Respiratory Burst in Mouse Macrophages
by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation
Mechanism.” FEBS Letters, vol. 355, no. 2, Elsevier, 1994, pp. 114–16,
doi:10.1016/0014-5793(94)01109-5.
short: A. Efanov, A. Koshkin, L.A. Sazanov, O.I. Borodulina, S. Varfolomeev, S.
Zaǐtsev, FEBS Letters 355 (1994) 114–116.
date_created: 2018-12-11T11:54:53Z
date_published: 1994-11-28T00:00:00Z
date_updated: 2022-06-09T12:58:57Z
day: '28'
doi: 10.1016/0014-5793(94)01109-5
extern: '1'
external_id:
pmid:
- '7982481'
intvolume: ' 355'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2901109-5
month: '11'
oa: 1
oa_version: Published Version
page: 114 - 116
pmid: 1
publication: FEBS Letters
publication_identifier:
issn:
- 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '5133'
quality_controlled: '1'
status: public
title: Inhibition of the respiratory burst in mouse macrophages by ultra-low doses
of an opioid peptide is consistent with a possible adaptation mechanism
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 355
year: '1994'
...
---
_id: '6167'
abstract:
- lang: eng
text: The tra-1 gene is the terminal regulator in the sex determination pathway
in C. elegans, directing all aspects of somatic sexual differentiation. Recessive
loss-of-function (lf) mutations in tra-1 masculinize XX animals (normally somatically
female), while dominant gain-of-function mutations feminize XO animals (normally
male). Most tra-1 (lf) mutations can be fitted into a simple allelic series of
somatic masculinization, but a small number of lf alleles do not fit into this
series. Here we show that three of these mutations are associated with DNA rearrangements
5' to the coding region. One allele is an inversion that may be subject to a position
effect. We also report the isolation of a new class of tra-1 alleles that are
responsive to mutations in the smg system of RNA surveillance. We show that two
of these express RNAs of aberrant size. We suggest that the smg-sensitive mutations
may identify a carboxy-terminal domain required for negative regulation of tra-1
activity.
author:
- first_name: David
full_name: Zarkower, David
last_name: Zarkower
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: Rachel
full_name: Aronoff, Rachel
last_name: Aronoff
- first_name: Jonathan
full_name: Hodgkin, Jonathan
last_name: Hodgkin
citation:
ama: Zarkower D, de Bono M, Aronoff R, Hodgkin J. Regulatory rearrangements and
smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental
Genetics. 1994;15(3):240-250. doi:10.1002/dvg.1020150306
apa: Zarkower, D., de Bono, M., Aronoff, R., & Hodgkin, J. (1994). Regulatory
rearrangements and smg-sensitive allels of the C. elegans sex-determining gene
tra-1. Developmental Genetics. Wiley. https://doi.org/10.1002/dvg.1020150306
chicago: Zarkower, David, Mario de Bono, Rachel Aronoff, and Jonathan Hodgkin. “Regulatory
Rearrangements and Smg-Sensitive Allels of the C. Elegans Sex-Determining Gene
Tra-1.” Developmental Genetics. Wiley, 1994. https://doi.org/10.1002/dvg.1020150306.
ieee: D. Zarkower, M. de Bono, R. Aronoff, and J. Hodgkin, “Regulatory rearrangements
and smg-sensitive allels of the C. elegans sex-determining gene tra-1,” Developmental
Genetics, vol. 15, no. 3. Wiley, pp. 240–250, 1994.
ista: Zarkower D, de Bono M, Aronoff R, Hodgkin J. 1994. Regulatory rearrangements
and smg-sensitive allels of the C. elegans sex-determining gene tra-1. Developmental
Genetics. 15(3), 240–250.
mla: Zarkower, David, et al. “Regulatory Rearrangements and Smg-Sensitive Allels
of the C. Elegans Sex-Determining Gene Tra-1.” Developmental Genetics,
vol. 15, no. 3, Wiley, 1994, pp. 240–50, doi:10.1002/dvg.1020150306.
short: D. Zarkower, M. de Bono, R. Aronoff, J. Hodgkin, Developmental Genetics 15
(1994) 240–250.
date_created: 2019-03-22T08:38:41Z
date_published: 1994-01-13T00:00:00Z
date_updated: 2021-01-12T08:06:30Z
day: '13'
doi: 10.1002/dvg.1020150306
extern: '1'
external_id:
pmid:
- '7520378'
intvolume: ' 15'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 240-250
pmid: 1
publication: Developmental Genetics
publication_identifier:
issn:
- 0192-253X
- 1520-6408
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Regulatory rearrangements and smg-sensitive allels of the C. elegans sex-determining
gene tra-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '1994'
...
---
_id: '3453'
alternative_title:
- Advances in second messenger and phosphoprotein research
article_processing_charge: No
author:
- first_name: Eberhard
full_name: Von Kitzing, Eberhard
last_name: Von Kitzing
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Von Kitzing E, Jonas PM, Sakmann B. Quantal analysis of excitatory postsynaptic
currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse. Molecular
and cellular mechanisms of neurotransmitter release. 1994;29:235-260. doi:10.1016/0166-2236(95)90088-8
apa: Von Kitzing, E., Jonas, P. M., & Sakmann, B. (1994). Quantal analysis of
excitatory postsynaptic currents at the hippocampal mossy fiber-CA3 pyramidal
cell synapse. Molecular and Cellular Mechanisms of Neurotransmitter Release.
Raven Press. https://doi.org/10.1016/0166-2236(95)90088-8
chicago: Von Kitzing, Eberhard, Peter M Jonas, and Bert Sakmann. “Quantal Analysis
of Excitatory Postsynaptic Currents at the Hippocampal Mossy Fiber-CA3 Pyramidal
Cell Synapse.” Molecular and Cellular Mechanisms of Neurotransmitter Release.
Raven Press, 1994. https://doi.org/10.1016/0166-2236(95)90088-8.
ieee: E. Von Kitzing, P. M. Jonas, and B. Sakmann, “Quantal analysis of excitatory
postsynaptic currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse,”
Molecular and cellular mechanisms of neurotransmitter release, vol. 29.
Raven Press, pp. 235–260, 1994.
ista: Von Kitzing E, Jonas PM, Sakmann B. 1994. Quantal analysis of excitatory postsynaptic
currents at the hippocampal mossy fiber-CA3 pyramidal cell synapse. Molecular
and cellular mechanisms of neurotransmitter release. 29, 235–260.
mla: Von Kitzing, Eberhard, et al. “Quantal Analysis of Excitatory Postsynaptic
Currents at the Hippocampal Mossy Fiber-CA3 Pyramidal Cell Synapse.” Molecular
and Cellular Mechanisms of Neurotransmitter Release, vol. 29, Raven Press,
1994, pp. 235–60, doi:10.1016/0166-2236(95)90088-8.
short: E. Von Kitzing, P.M. Jonas, B. Sakmann, Molecular and Cellular Mechanisms
of Neurotransmitter Release 29 (1994) 235–260.
date_created: 2018-12-11T12:03:24Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-03T11:46:09Z
day: '01'
doi: 10.1016/0166-2236(95)90088-8
extern: '1'
external_id:
pmid:
- '7848714 '
intvolume: ' 29'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0166223695900888?via%3Dihub
month: '01'
oa_version: None
page: 235 - 260
pmid: 1
publication: Molecular and cellular mechanisms of neurotransmitter release
publication_identifier:
isbn:
- '0781702208'
publication_status: published
publisher: Raven Press
publist_id: '2934'
quality_controlled: '1'
status: public
title: Quantal analysis of excitatory postsynaptic currents at the hippocampal mossy
fiber-CA3 pyramidal cell synapse
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 29
year: '1994'
...
---
_id: '3460'
abstract:
- lang: eng
text: Excitatory postsynaptic currents in neurones of the central nervous system
have a dual-component time course that results from the co-activation of AMPA/kainate-type
and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular
biology have provided a better understanding of the factors that determine the
kinectics of excitatory postsynaptic currents. Recent studies suggest that the
time course of neurotransmitter concentration in the synaptic cleft, the gating
properties of the native channels, and the glutamate receptor subunit composition
all appear to be important factors.
acknowledgement: 'We thank JGG Borst, N Burnashev, M Häusser, G Stuart and A Viilarroel
for critically reading the manuscript and E von Kitzing and A Roth for doing the
simulations and for many helpful discussions. Supported by the Deutsche Forschungsgemeinschaft
(SFB 317-B14) and the Alexander von Humboldt Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Nelson
full_name: Spruston, Nelson
last_name: Spruston
citation:
ama: Jonas PM, Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic
currents in the CNS. Current Opinion in Neurobiology. 1994;4(3):366-372.
doi:10.1016/0959-4388(94)90098-1
apa: Jonas, P. M., & Spruston, N. (1994). Mechanisms shaping glutamate-mediated
excitatory postsynaptic currents in the CNS. Current Opinion in Neurobiology.
Elsevier. https://doi.org/10.1016/0959-4388(94)90098-1
chicago: Jonas, Peter M, and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology.
Elsevier, 1994. https://doi.org/10.1016/0959-4388(94)90098-1.
ieee: P. M. Jonas and N. Spruston, “Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS,” Current Opinion in Neurobiology, vol.
4, no. 3. Elsevier, pp. 366–372, 1994.
ista: Jonas PM, Spruston N. 1994. Mechanisms shaping glutamate-mediated excitatory
postsynaptic currents in the CNS. Current Opinion in Neurobiology. 4(3), 366–372.
mla: Jonas, Peter M., and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
Excitatory Postsynaptic Currents in the CNS.” Current Opinion in Neurobiology,
vol. 4, no. 3, Elsevier, 1994, pp. 366–72, doi:10.1016/0959-4388(94)90098-1.
short: P.M. Jonas, N. Spruston, Current Opinion in Neurobiology 4 (1994) 366–372.
date_created: 2018-12-11T12:03:27Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-03T11:26:52Z
day: '01'
doi: 10.1016/0959-4388(94)90098-1
extern: '1'
external_id:
pmid:
- '7522678 '
intvolume: ' 4'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0959438894900981?via%3Dihub
month: '06'
oa_version: None
page: 366 - 372
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '2927'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the
CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '1994'
...
---
_id: '3475'
abstract:
- lang: eng
text: '1. A potassium channel activated by internal Na+ ions (K+Na channel) was
identified in peripheral myelinated axons of Xenopus laevis using the cell-attached
and excised configurations of the patch clamp technique. 2. The single-channel
conductance for the main open state was 88 pS with [K+]o = 105 mM and pS with
[K+]o = 2.5 mM ([K+]i = 105 mM). The channel was selectively permeable to K+ over
Na+ ions. A characteristic feature of the K+Na channel was the frequent occurrence
of subconductance states. 3. The open probability of the channel was strongly
dependent on the concentration of Na+ ions at the inner side of the membrane.
The half-maximal activating Na+ concentration and the Hill coefficient were 33
mM and 2.9, respectively. The open probability of the channel showed only weak
potential dependence. 4. The K+Na channel was relatively insensitive to external
tetraethylammonium (TEA+) in comparison with voltage-dependent axonal K+ channels;
the half-maximal inhibitory concentration (IC50) was 21.3 mM (at -90 mV). In contrast,
the channel was blocked by low concentrations of external Ba2+ and Cs+ ions, with
IC50 values of 0.7 and 1.1 mM, respectively (at -90 mV). The block by Ba2+ and
Cs+ was more pronounced at negative than at positive membrane potentials. 5. A
comparison of the number of K+Na channels in nodal and paranodal patches from
the same axon revealed that the channel density was about 10-fold higher at the
node of Ranvier than at the paranode. Moreover, a correlation between the number
of K+Na channels and voltage-dependent Na+ channels in the same patches was found,
suggesting co-localization of both channel types. 6. As weakly potential-dependent
(''leakage'') channels, axonal K+Na channels may be involved in setting the resting
potential of vertebrate axons. Simulations of Na+ ion diffusion suggest two possible
mechanisms of activation of K+Na channels: the local increase of Na+ concentration
in a cluster of Na+ channels during a single action potential or the accumulation
in the intracellular axonal compartment during a train of action potentials.'
acknowledgement: 'We thank Drs M.Häusser and A. Villarroel for critically reading
the manuscript, Dr E. v. Kitzing and A. Roth for many helpful discussions. This
work was supported by the Deutsche Forschungsgemeinschaft (Vo188/13-2). '
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Werner
full_name: Vogel, Werner
last_name: Vogel
citation:
ama: Koh D, Jonas PM, Vogel W. Na+-activated K+ channels localized in the nodal
region of myelinated axons of Xenopus. Journal of Physiology. 1994;479:183-197.
doi:10.1113/jphysiol.1994.sp020287
apa: Koh, D., Jonas, P. M., & Vogel, W. (1994). Na+-activated K+ channels localized
in the nodal region of myelinated axons of Xenopus. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1994.sp020287
chicago: Koh, Duk, Peter M Jonas, and Werner Vogel. “Na+-Activated K+ Channels Localized
in the Nodal Region of Myelinated Axons of Xenopus.” Journal of Physiology.
Wiley-Blackwell, 1994. https://doi.org/10.1113/jphysiol.1994.sp020287.
ieee: D. Koh, P. M. Jonas, and W. Vogel, “Na+-activated K+ channels localized in
the nodal region of myelinated axons of Xenopus,” Journal of Physiology,
vol. 479. Wiley-Blackwell, pp. 183–197, 1994.
ista: Koh D, Jonas PM, Vogel W. 1994. Na+-activated K+ channels localized in the
nodal region of myelinated axons of Xenopus. Journal of Physiology. 479, 183–197.
mla: Koh, Duk, et al. “Na+-Activated K+ Channels Localized in the Nodal Region of
Myelinated Axons of Xenopus.” Journal of Physiology, vol. 479, Wiley-Blackwell,
1994, pp. 183–97, doi:10.1113/jphysiol.1994.sp020287.
short: D. Koh, P.M. Jonas, W. Vogel, Journal of Physiology 479 (1994) 183–197.
date_created: 2018-12-11T12:03:31Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2022-06-03T11:09:21Z
day: '01'
doi: 10.1113/jphysiol.1994.sp020287
extern: '1'
external_id:
pmid:
- '7799220 '
intvolume: ' 479'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1155738/
month: '01'
oa: 1
oa_version: Published Version
page: 183 - 197
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2912'
quality_controlled: '1'
status: public
title: Na+-activated K+ channels localized in the nodal region of myelinated axons
of Xenopus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 479
year: '1994'
...
---
_id: '3476'
abstract:
- lang: eng
text: Tight-seal whole-cell recordings were made from cleaned somata of CA3 pyramidal
cells deep in hippocampal slices from 19–21-d-old rats. The cells were filled
with biocytin, and their voltage responses to short current pulses were recorded.
After washout of initial sag, responses scaled linearly with injected current
and were stable over time. The dendritic and axonal arbors of four cells were
reconstructed and measured using light microscopy. Dendritic spines and axonal
boutons were counted and the additional membrane area was incorporated into the
relevant segments. The morphology of each neuron was converted into a detailed
branching cable model by assuming values for specific membrane capacitance Cm
and resistance Rm, and cytoplasmic resistivity Ri. These parameters were optimized
for each cell by directly matching the model's response to that of the real cell
by means of a modified weighted least-squares fitting procedure. By comparing
the deviations between model and experimental responses to control noise recordings,
approximate 95% confidence intervals were established for each parameter. If a
somatic shunt was allowed, a wide range of possible Rm values produced acceptable
fits. With zero shunt, Cm was 0.7–0.8 microFcm-2, Ri was 170–340 omega cm, and
Rm ranged between 120 and 200 k omega cm2. The electrotonic lengths of the basal
and oblique dendrites were 0.2–0.3 space constants, and those of the apical tufts
were 0.4–0.7 space constants. The steady-state electrical geometry of these cells
was therefore compact; average dendritic tip/soma relative synaptic efficacies
were > 93% for the basal and oblique dendrites, and > 81% for the tufts.
With fast transient synaptic inputs, however, the models produced a wide range
of postsynaptic potential shapes and marked filtering of voltage-clamp currents.
acknowledgement: 'logy Training Fellowship. A.L. was supported by a Royal Society
Fellowship. The Oxford part of the collaboration was funded by a Wellcome Trust
Programme Grant, the Heidelberg part by the Max-Planck Gesellschaft. We are grateful
to Sir David Cox for his comments on the statistics, to K. Stratford, M. Hausser,
D. Flitney, M. O’Neill, S. Gough, G. Stuart, N. Spruston, P. Stem, and K. Bauer
for their help and useful discussions, and to M. Kaiser for technical assistance. '
article_processing_charge: No
article_type: original
author:
- first_name: Guy
full_name: Major, Guy
last_name: Major
- first_name: Alan
full_name: Larkman, Alan
last_name: Larkman
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Julian
full_name: Jack, Julian
last_name: Jack
citation:
ama: Major G, Larkman A, Jonas PM, Sakmann B, Jack J. Detailed passive cable models
of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. Journal
of Neuroscience. 1994;14(8):4613-4638. doi:10.1523/JNEUROSCI.14-08-04613.1994
apa: Major, G., Larkman, A., Jonas, P. M., Sakmann, B., & Jack, J. (1994). Detailed
passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal
slices. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.14-08-04613.1994
chicago: Major, Guy, Alan Larkman, Peter M Jonas, Bert Sakmann, and Julian Jack.
“Detailed Passive Cable Models of Whole-Cell Recorded CA3 Pyramidal Neurons in
Rat Hippocampal Slices.” Journal of Neuroscience. Society for Neuroscience,
1994. https://doi.org/10.1523/JNEUROSCI.14-08-04613.1994.
ieee: G. Major, A. Larkman, P. M. Jonas, B. Sakmann, and J. Jack, “Detailed passive
cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices,”
Journal of Neuroscience, vol. 14, no. 8. Society for Neuroscience, pp.
4613–4638, 1994.
ista: Major G, Larkman A, Jonas PM, Sakmann B, Jack J. 1994. Detailed passive cable
models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices.
Journal of Neuroscience. 14(8), 4613–4638.
mla: Major, Guy, et al. “Detailed Passive Cable Models of Whole-Cell Recorded CA3
Pyramidal Neurons in Rat Hippocampal Slices.” Journal of Neuroscience,
vol. 14, no. 8, Society for Neuroscience, 1994, pp. 4613–38, doi:10.1523/JNEUROSCI.14-08-04613.1994.
short: G. Major, A. Larkman, P.M. Jonas, B. Sakmann, J. Jack, Journal of Neuroscience
14 (1994) 4613–4638.
date_created: 2018-12-11T12:03:32Z
date_published: 1994-08-01T00:00:00Z
date_updated: 2022-06-03T09:36:43Z
day: '01'
doi: 10.1523/JNEUROSCI.14-08-04613.1994
extern: '1'
external_id:
pmid:
- '8046439 '
intvolume: ' 14'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/med/8046439
month: '08'
oa: 1
oa_version: Published Version
page: 4613 - 4638
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2911'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons
in rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 14
year: '1994'
...
---
_id: '3477'
abstract:
- lang: eng
text: Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type
glutamate receptor (GluR) channels. Heterologous expression suggested that the
Ca2+ permeability of these receptors critically depends on the subunit composition.
Using patch-clamp techniques in brain slices, we found that the Ca2+ permeability
of native AMPA-type GluRs was markedly higher in nonpyramidal (P(Ca)/P(K) ≃ 0.63)
than in pyramidal (P(Ca)/P(K) ≃ 0.05) neurons of rat neocortex. Analysis of mRNA
in single cells indicated that the relative abundance of GluR-B-specific mRNA
was significantly lower in nonpyramidal (GluR-B/GluR-non-B ≃ 0.3) than in pyramidal
(GluR-B/GluR-non-B ≃ 3) cells. This suggests that differences in relative abundance
of GluR-B- specific mRNA generate functional diversity of AMPA-type GluRs in neurons
with respect to Ca2+ permeability.
acknowledgement: We thank Drs. B. Lambolez and J. Rossier for helping to establish
the method of single-cell PCR, Dr. M. Frotscher for help with cell identification,
Dr. N. Spruston for critically reading the manuscript, and M. Kaiser and U. Keller
for technical assistance. This work was supported in part by BMFT grant BCT 364
AZ 3211 7291 (P. H. S.) and by DFG grant SFB-317/B14 (P. J.). The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC Section
1734 solely to indicate this fact.
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Claudia
full_name: Racca, Claudia
last_name: Racca
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
citation:
ama: Jonas PM, Racca C, Sakmann B, Seeburg P, Monyer H. Differences in Ca(2+) permeability
of AMPA-type glutamate receptor channels in neocortical neurons caused by differential
GluR-B subunit expression. Neuron. 1994;12(6):1281-1289. doi:10.1016/0896-6273(94)90444-8
apa: Jonas, P. M., Racca, C., Sakmann, B., Seeburg, P., & Monyer, H. (1994).
Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in
neocortical neurons caused by differential GluR-B subunit expression. Neuron.
Elsevier. https://doi.org/10.1016/0896-6273(94)90444-8
chicago: Jonas, Peter M, Claudia Racca, Bert Sakmann, Peter Seeburg, and Hannah
Monyer. “Differences in Ca(2+) Permeability of AMPA-Type Glutamate Receptor Channels
in Neocortical Neurons Caused by Differential GluR-B Subunit Expression.” Neuron.
Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90444-8.
ieee: P. M. Jonas, C. Racca, B. Sakmann, P. Seeburg, and H. Monyer, “Differences
in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical
neurons caused by differential GluR-B subunit expression,” Neuron, vol.
12, no. 6. Elsevier, pp. 1281–1289, 1994.
ista: Jonas PM, Racca C, Sakmann B, Seeburg P, Monyer H. 1994. Differences in Ca(2+)
permeability of AMPA-type glutamate receptor channels in neocortical neurons caused
by differential GluR-B subunit expression. Neuron. 12(6), 1281–1289.
mla: Jonas, Peter M., et al. “Differences in Ca(2+) Permeability of AMPA-Type Glutamate
Receptor Channels in Neocortical Neurons Caused by Differential GluR-B Subunit
Expression.” Neuron, vol. 12, no. 6, Elsevier, 1994, pp. 1281–89, doi:10.1016/0896-6273(94)90444-8.
short: P.M. Jonas, C. Racca, B. Sakmann, P. Seeburg, H. Monyer, Neuron 12 (1994)
1281–1289.
date_created: 2018-12-11T12:03:32Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-03T09:29:36Z
day: '01'
doi: 10.1016/0896-6273(94)90444-8
extern: '1'
external_id:
pmid:
- '8011338 '
intvolume: ' 12'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0896627394904448?via%3Dihub
month: '06'
oa_version: None
page: 1281 - 1289
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2910'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels
in neocortical neurons caused by differential GluR-B subunit expression
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1994'
...
---
_id: '3550'
acknowledgement: This work is partially supported by the National Science Foundation,
under grant ASC-9200301 and the Alan T. Waterman award, grant CCR-9118874
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Modeling with simplicial complexes (topology, geometry and
algorithms). In: Proceedings of the 6th Canadian Conference on Computational
Geometry. ; 1994:36-44.'
apa: Edelsbrunner, H. (1994). Modeling with simplicial complexes (topology, geometry
and algorithms). In Proceedings of the 6th Canadian Conference on Computational
Geometry (pp. 36–44). Saskatoon, Canada.
chicago: Edelsbrunner, Herbert. “Modeling with Simplicial Complexes (Topology, Geometry
and Algorithms).” In Proceedings of the 6th Canadian Conference on Computational
Geometry, 36–44, 1994.
ieee: H. Edelsbrunner, “Modeling with simplicial complexes (topology, geometry and
algorithms),” in Proceedings of the 6th Canadian Conference on Computational
Geometry, Saskatoon, Canada, 1994, pp. 36–44.
ista: 'Edelsbrunner H. 1994. Modeling with simplicial complexes (topology, geometry
and algorithms). Proceedings of the 6th Canadian Conference on Computational Geometry.
CCCG: Canadian Conference on Computational Geometry, 36–44.'
mla: Edelsbrunner, Herbert. “Modeling with Simplicial Complexes (Topology, Geometry
and Algorithms).” Proceedings of the 6th Canadian Conference on Computational
Geometry, 1994, pp. 36–44.
short: H. Edelsbrunner, in:, Proceedings of the 6th Canadian Conference on Computational
Geometry, 1994, pp. 36–44.
conference:
location: Saskatoon, Canada
name: 'CCCG: Canadian Conference on Computational Geometry'
date_created: 2018-12-11T12:03:55Z
date_published: 1994-08-01T00:00:00Z
date_updated: 2022-06-03T08:50:45Z
day: '01'
extern: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 36 - 44
publication: Proceedings of the 6th Canadian Conference on Computational Geometry
publication_status: published
publist_id: '2835'
quality_controlled: '1'
status: public
title: Modeling with simplicial complexes (topology, geometry and algorithms)
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1994'
...
---
_id: '3641'
abstract:
- lang: eng
text: The probability of fixation of a mutation with selective advantage s will
be reduced by substitutions at other loci. The effect of a single substitution,
with selective advantage S0016672300032857inline1, can be approximated as a sudden
reduction in the frequency of the favourable allele, by a fraction w = 1 −(s/S)r/s
(where r is the recombination rate). An expression for the effect of a given sequence
of such catastrophes is derived. This also applies to the ecological prxoblem
of finding the probability that a small population will survive, despite occasional
disasters. It is shown that if substitutions occur at a rate Δ, and are scattered
randomly over a genetic map of length R, then an allele is unlikely to be fixed
if its advantage is less than a critical value, Scrit = (π2/6)(2ΔS/(Rlog(S/s))).
This threshold depends primarily on the variance in fitness per unit map length
dueto substitutions, var(W)/R = 2ΔS/R. With no recombination, the fixation probability
can be calculated for a finite population. If Δ > s, it is of the same order
as for a neutral allele ( ≈ Δ/(2N(Δ−s))), whilst if S0016672300032857inline2,
fixation probability is much higher than for a neutral allele, but much lower
than in the absence of hitch-hiking S0016672300032857inline3. These results suggest
that hitch-hiking may substantially impede the accumulation of weakly favoured
adaptations.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The reduction in fixation probability caused by substitutions at
linked loci. Genetical Research. 1994;64(3):199-208. doi:10.1017/S0016672300032857
apa: Barton, N. H. (1994). The reduction in fixation probability caused by substitutions
at linked loci. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672300032857
chicago: Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions
at Linked Loci.” Genetical Research. Cambridge University Press, 1994.
https://doi.org/10.1017/S0016672300032857
.
ieee: N. H. Barton, “The reduction in fixation probability caused by substitutions
at linked loci,” Genetical Research, vol. 64, no. 3. Cambridge University
Press, pp. 199–208, 1994.
ista: Barton NH. 1994. The reduction in fixation probability caused by substitutions
at linked loci. Genetical Research. 64(3), 199–208.
mla: Barton, Nicholas H. “The Reduction in Fixation Probability Caused by Substitutions
at Linked Loci.” Genetical Research, vol. 64, no. 3, Cambridge University
Press, 1994, pp. 199–208, doi:10.1017/S0016672300032857 .
short: N.H. Barton, Genetical Research 64 (1994) 199–208.
date_created: 2018-12-11T12:04:23Z
date_published: 1994-12-01T00:00:00Z
date_updated: 2022-06-03T08:34:32Z
day: '01'
doi: '10.1017/S0016672300032857 '
extern: '1'
intvolume: ' 64'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/reduction-in-fixation-probability-caused-by-substitutions-at-linked-loci/458BBF3E7FE92E4EA6AFB2B000A98945
month: '12'
oa_version: None
page: 199 - 208
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2742'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The reduction in fixation probability caused by substitutions at linked loci
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 64
year: '1994'
...
---
_id: '3642'
abstract:
- lang: eng
text: We develop a general population genetic framework for analyzing selection
on many loci, and apply it to strong truncation and disruptive selection on an
additive polygenic trait. We first present statistical methods for analyzing the
infinitesimal model, in which offspring breeding values are normally distributed
around the mean of the parents, with fixed variance. These show that the usual
assumption of a Gaussian distribution of breeding values in the population gives
remarkably accurate predictions for the mean and the variance, even when disruptive
selection generates substantial deviations from normality. We then set out a general
genetic analysis of selection and recombination. The population is represented
by multilocus cumulants describing the distribution of haploid genotypes, and
selection is described by the relation between mean fitness and these cumulants.
We provide exact recursions in terms of generating functions for the effects of
selection on non-central moments. The effects of recombination are simply calculated
as a weighted sum over all the permutations produced by meiosis. Finally, the
new cumulants that describe the next generation are computed from the non-central
moments. Although this scheme is applied here in detail only to selection on an
additive trait, it is quite general. For arbitrary epistasis and linkage, we describe
a consistent infinitesimal limit in which the short-term selection response is
dominated by infinitesimal allele frequency changes and linkage disequilibria.
Numerical multilocus results show that the standard Gaussian approximation gives
accurate predictions for the dynamics of the mean and genetic variance in this
limit. Even with intense truncation selection, linkage disequilibria of order
three and higher never cause much deviation from normality. Thus, the empirical
deviations frequently found between predicted and observed responses to artificial
selection are not caused by linkage-disequilibrium-induced departures from normality.
Disruptive selection can generate substantial four-way disequilibria, and hence
kurtosis; but even then, the Gaussian assumption predicts the variance accurately.
In contrast to the apparent simplicity of the infinitesimal limit, data suggest
that changes in genetic variance after 10 or more generations of selection are
likely to be dominated by allele frequency dynamics that depend on genetic details.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Turelli M, Barton NH. Genetic and statistical analyses of strong selection
on polygenic traits: What, me normal? Genetics. 1994;138(3):913-941. doi:10.1093/genetics/138.3.913'
apa: 'Turelli, M., & Barton, N. H. (1994). Genetic and statistical analyses
of strong selection on polygenic traits: What, me normal? Genetics. Genetics
Society of America. https://doi.org/10.1093/genetics/138.3.913'
chicago: 'Turelli, Michael, and Nicholas H Barton. “Genetic and Statistical Analyses
of Strong Selection on Polygenic Traits: What, Me Normal?” Genetics. Genetics
Society of America, 1994. https://doi.org/10.1093/genetics/138.3.913.'
ieee: 'M. Turelli and N. H. Barton, “Genetic and statistical analyses of strong
selection on polygenic traits: What, me normal?,” Genetics, vol. 138, no.
3. Genetics Society of America, pp. 913–941, 1994.'
ista: 'Turelli M, Barton NH. 1994. Genetic and statistical analyses of strong selection
on polygenic traits: What, me normal? Genetics. 138(3), 913–941.'
mla: 'Turelli, Michael, and Nicholas H. Barton. “Genetic and Statistical Analyses
of Strong Selection on Polygenic Traits: What, Me Normal?” Genetics, vol.
138, no. 3, Genetics Society of America, 1994, pp. 913–41, doi:10.1093/genetics/138.3.913.'
short: M. Turelli, N.H. Barton, Genetics 138 (1994) 913–941.
date_created: 2018-12-11T12:04:24Z
date_published: 1994-11-01T00:00:00Z
date_updated: 2022-06-03T08:18:54Z
day: '01'
doi: 10.1093/genetics/138.3.913
extern: '1'
external_id:
pmid:
- '7851785'
intvolume: ' 138'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/7851785/
month: '11'
oa: 1
oa_version: Published Version
page: 913 - 941
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2741'
quality_controlled: '1'
status: public
title: 'Genetic and statistical analyses of strong selection on polygenic traits:
What, me normal?'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 138
year: '1994'
...
---
_id: '4032'
abstract:
- lang: eng
text: Every collection of t≥2 n2 triangles with a total of n vertices in ℝ3 has
Ω(t4/n6) crossing pairs. This implies that one of their edges meets Ω(t3/n6) of
the triangles. From this it follows that n points in ℝ3 have only O(n8/3) halving
planes.
acknowledgement: The research of H. Edelsbrunner was supported by the National Science
Foundation under Grant CCR-8921421 and under an Alan T. Waterman award, Grant CCR-9118874.
Any opinions, findings and conclusions or recommendations expressed in this publication
are those of the authors and do not necessarily reflect the view of the National
Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Dey T, Edelsbrunner H. Counting triangle crossings and halving planes. Discrete
& Computational Geometry. 1994;12(1):281-289. doi:10.1007/BF02574381
apa: Dey, T., & Edelsbrunner, H. (1994). Counting triangle crossings and halving
planes. Discrete & Computational Geometry. Springer. https://doi.org/10.1007/BF02574381
chicago: Dey, Tamal, and Herbert Edelsbrunner. “Counting Triangle Crossings and
Halving Planes.” Discrete & Computational Geometry. Springer, 1994.
https://doi.org/10.1007/BF02574381.
ieee: T. Dey and H. Edelsbrunner, “Counting triangle crossings and halving planes,”
Discrete & Computational Geometry, vol. 12, no. 1. Springer, pp. 281–289,
1994.
ista: Dey T, Edelsbrunner H. 1994. Counting triangle crossings and halving planes.
Discrete & Computational Geometry. 12(1), 281–289.
mla: Dey, Tamal, and Herbert Edelsbrunner. “Counting Triangle Crossings and Halving
Planes.” Discrete & Computational Geometry, vol. 12, no. 1, Springer,
1994, pp. 281–89, doi:10.1007/BF02574381.
short: T. Dey, H. Edelsbrunner, Discrete & Computational Geometry 12 (1994)
281–289.
date_created: 2018-12-11T12:06:33Z
date_published: 1994-09-01T00:00:00Z
date_updated: 2022-06-02T12:53:01Z
day: '01'
doi: 10.1007/BF02574381
extern: '1'
intvolume: ' 12'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02574381
month: '09'
oa_version: None
page: 281 - 289
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2091'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting triangle crossings and halving planes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1994'
...