---
_id: '6162'
abstract:
- lang: eng
text: 'The tra-1 gene is the terminal global selector of somatic sex in Caenorhabditis
elegans: High tra-1 activity elicits female somatic development while low tra-1
activity elicits male development. Previous genetic studies defined a cascade
of negatively interacting genes that regulates tra-1 activity in response to the
primary sex-determining signal. Here, we investigate the last step in this regulatory
cascade, by studying rare gain-of-function (gf) mutations of tra-1 that direct
female somatic development irrespective of the upstream sex-determining signal.
These mutations appear to abolish negative regulation of tra-1 in male tissues.
We identify the lesions associated with 29 of these mutations and find that all
affect a short stretch of amino acid residues present in both protein products
of the tra-1 gene. Twenty-six alleles are associated with single nonconservative
amino acid substitutions. Two alleles affect tra-1 RNA splicing and generate messages
that omit part or all of the exon encoding this short stretch. These results suggest
that sexual regulation of tra-1 is achieved post-translationally, by an inhibitory
protein-protein interaction. The amino acid stretch altered by the tra-1(gf) mutations
may define a site of interaction for negative regulators of tra-1. The stretch
includes a potential phosphorylation site for glycogen synthase kinase 3 and may
be conserved in the human gene GLI3, a homolog of tra-1 identified previously.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: D.
full_name: Zarkower, D.
last_name: Zarkower
- first_name: J.
full_name: Hodgkin, J.
last_name: Hodgkin
citation:
ama: de Bono M, Zarkower D, Hodgkin J. Dominant feminizing mutations implicate protein-protein
interactions as the main mode of regulation of the nematode sex-determining gene
tra-1. Genes and Development. 1995;9(2):155-167. doi:10.1101/gad.9.2.155
apa: de Bono, M., Zarkower, D., & Hodgkin, J. (1995). Dominant feminizing mutations
implicate protein-protein interactions as the main mode of regulation of the nematode
sex-determining gene tra-1. Genes and Development. CSH Press. https://doi.org/10.1101/gad.9.2.155
chicago: Bono, Mario de, D. Zarkower, and J. Hodgkin. “Dominant Feminizing Mutations
Implicate Protein-Protein Interactions as the Main Mode of Regulation of the Nematode
Sex-Determining Gene Tra-1.” Genes and Development. CSH Press, 1995. https://doi.org/10.1101/gad.9.2.155.
ieee: M. de Bono, D. Zarkower, and J. Hodgkin, “Dominant feminizing mutations implicate
protein-protein interactions as the main mode of regulation of the nematode sex-determining
gene tra-1,” Genes and Development, vol. 9, no. 2. CSH Press, pp. 155–167,
1995.
ista: de Bono M, Zarkower D, Hodgkin J. 1995. Dominant feminizing mutations implicate
protein-protein interactions as the main mode of regulation of the nematode sex-determining
gene tra-1. Genes and Development. 9(2), 155–167.
mla: de Bono, Mario, et al. “Dominant Feminizing Mutations Implicate Protein-Protein
Interactions as the Main Mode of Regulation of the Nematode Sex-Determining Gene
Tra-1.” Genes and Development, vol. 9, no. 2, CSH Press, 1995, pp. 155–67,
doi:10.1101/gad.9.2.155.
short: M. de Bono, D. Zarkower, J. Hodgkin, Genes and Development 9 (1995) 155–167.
date_created: 2019-03-21T11:57:40Z
date_published: 1995-01-15T00:00:00Z
date_updated: 2021-01-12T08:06:29Z
day: '15'
doi: 10.1101/gad.9.2.155
extern: '1'
external_id:
pmid:
- '7851791'
intvolume: ' 9'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 155-167
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- '08909369'
publication_status: published
publisher: CSH Press
quality_controlled: '1'
status: public
title: Dominant feminizing mutations implicate protein-protein interactions as the
main mode of regulation of the nematode sex-determining gene tra-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '1995'
...
---
_id: '11805'
abstract:
- lang: eng
text: In this paper, we present sparse certificates for biconnectivity together
with algorithms for updating these certificates. We thus obtain fully-dynamic
algorithms for biconnectivity in graphs that run in O(√n log n log⌈m/n⌉) amortized
time per operation, where m is the number of edges and n is the number of nodes
in the graph. This improves upon the results in [11], in which algorithms were
presented running in O(√m) amortized time, and solves the open problem to find
certificates to speed up biconnectivity, as stated in [2].
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Han
full_name: Poutré, Han
last_name: Poutré
citation:
ama: 'Henzinger MH, Poutré H. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. In: 3rd Annual European Symposium on Algorithms.
Vol 979. Springer Nature; 1995:171–184. doi:10.1007/3-540-60313-1_142'
apa: 'Henzinger, M. H., & Poutré, H. (1995). Certificates and fast algorithms
for biconnectivity in fully-dynamic graphs. In 3rd Annual European Symposium
on Algorithms (Vol. 979, pp. 171–184). Corfu, Greece: Springer Nature. https://doi.org/10.1007/3-540-60313-1_142'
chicago: Henzinger, Monika H, and Han Poutré. “Certificates and Fast Algorithms
for Biconnectivity in Fully-Dynamic Graphs.” In 3rd Annual European Symposium
on Algorithms, 979:171–184. Springer Nature, 1995. https://doi.org/10.1007/3-540-60313-1_142.
ieee: M. H. Henzinger and H. Poutré, “Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs,” in 3rd Annual European Symposium on Algorithms,
Corfu, Greece, 1995, vol. 979, pp. 171–184.
ista: 'Henzinger MH, Poutré H. 1995. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. 3rd Annual European Symposium on Algorithms. ESA: European
Symposium on Algorithms, LNCS, vol. 979, 171–184.'
mla: Henzinger, Monika H., and Han Poutré. “Certificates and Fast Algorithms for
Biconnectivity in Fully-Dynamic Graphs.” 3rd Annual European Symposium on Algorithms,
vol. 979, Springer Nature, 1995, pp. 171–184, doi:10.1007/3-540-60313-1_142.
short: M.H. Henzinger, H. Poutré, in:, 3rd Annual European Symposium on Algorithms,
Springer Nature, 1995, pp. 171–184.
conference:
end_date: 1995-09-27
location: Corfu, Greece
name: 'ESA: European Symposium on Algorithms'
start_date: 1995-09-25
date_created: 2022-08-11T14:09:52Z
date_published: 1995-09-01T00:00:00Z
date_updated: 2023-02-14T08:02:03Z
day: '01'
doi: 10.1007/3-540-60313-1_142
extern: '1'
intvolume: ' 979'
language:
- iso: eng
month: '09'
oa_version: None
page: 171–184
publication: 3rd Annual European Symposium on Algorithms
publication_identifier:
eisbn:
- '9783540449133'
eissn:
- 1611-3349
isbn:
- '9783540603139'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Certificates and fast algorithms for biconnectivity in fully-dynamic graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 979
year: '1995'
...
---
_id: '11806'
abstract:
- lang: eng
text: This paper presents insertions-only algorithms for maintaining the exact and
approximate size of the minimum edge cut and the minimum vertex cut of a graph.
The algorithms output the approximate or exact size k in time O(1) or O(log n)
and a cut of size k in time linear in its size. The amortized time per insertion
is O(1/ε 2) for a (2+ε)-approximation, O((log λ)((log n)/ε)2) for a (1+ε)-approximation,
and O(λ log n) for the exact size of the minimum edge cut, where n is the number
of nodes in the graph, λ is the size of the minimum cut and ε>0. The (2+ε)-approximation
algorithm and the exact algorithm are deterministic, the (1+ε)-approximation algorithm
is randomized. The algorithms are optimal in the sense that the time needed for
m insertions matches the time needed by the best static algorithm on a m-edge
graph. We also present a static 2-approximation algorithm for the size κ of the
minimum vertex cut in a graph, which takes time O(n 2 min(√n,κ)). This is a factor
of κ faster than the best algorithm for computing the exact size, which takes
time O(κ 2 n 2 +κ 3 n 1.5). We give an insertionsonly algorithm for maintaining
a (2+ε)-approximation of the minimum vertex cut with amortized insertion time
O(n(logκk)/ε).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Approximating minimum cuts under insertions. In: 22nd International
Colloquium on Automata, Languages and Programming. Vol 944. Springer Nature;
1995:280–291. doi:10.1007/3-540-60084-1_81'
apa: 'Henzinger, M. H. (1995). Approximating minimum cuts under insertions. In 22nd
International Colloquium on Automata, Languages and Programming (Vol. 944,
pp. 280–291). Szeged, Hungary: Springer Nature. https://doi.org/10.1007/3-540-60084-1_81'
chicago: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” In
22nd International Colloquium on Automata, Languages and Programming, 944:280–291.
Springer Nature, 1995. https://doi.org/10.1007/3-540-60084-1_81.
ieee: M. H. Henzinger, “Approximating minimum cuts under insertions,” in 22nd
International Colloquium on Automata, Languages and Programming, Szeged, Hungary,
1995, vol. 944, pp. 280–291.
ista: 'Henzinger MH. 1995. Approximating minimum cuts under insertions. 22nd International
Colloquium on Automata, Languages and Programming. ICALP: International Colloquium
on Automata, Languages, and Programming, LNCS, vol. 944, 280–291.'
mla: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” 22nd
International Colloquium on Automata, Languages and Programming, vol. 944,
Springer Nature, 1995, pp. 280–291, doi:10.1007/3-540-60084-1_81.
short: M.H. Henzinger, in:, 22nd International Colloquium on Automata, Languages
and Programming, Springer Nature, 1995, pp. 280–291.
conference:
end_date: 1995-07-14
location: Szeged, Hungary
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 1995-07-10
date_created: 2022-08-11T14:17:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2023-02-14T08:09:08Z
day: '01'
doi: 10.1007/3-540-60084-1_81
extern: '1'
intvolume: ' 944'
language:
- iso: eng
month: '07'
oa_version: None
page: 280–291
publication: 22nd International Colloquium on Automata, Languages and Programming
publication_identifier:
eisbn:
- '9783540600848'
eissn:
- 1611-3349
isbn:
- '9783540494256'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Approximating minimum cuts under insertions
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 944
year: '1995'
...
---
_id: '11928'
abstract:
- lang: eng
text: "We present a model with restricted randomness for edge updates in dynamic
graph algorithms and a general technique\r\nfor analyzing the expected running
time of an update operation. This model is able to capture the average case in
many applications, since (1) it allows restrictions on the set of edges which
can be used for insertions and (2) the type (insertion or deletion) of each update
operation is arbitrary, i.e., not random. We use our technique to analyze existing
and new dynamic algorithms for maximum cardinality matching, minimum spanning
forest, connectivity, 2-edge connectivity,\r\nk-edge connectivity, k-vertex connectivity,
and bipartiteness. Given a random graph G with mo edges and n vertices and\r\na
sequence of 1 update operations such that the graph contains rni edges after operation
i, the expected time for performing the updates for any 1 is O(1 logn + n xi=,
l/fii) in the case of minimum spanning forests, connectivity, 2-\r\nedge connectivity,
and bipartiteness. The expected time per update operation is O(n) in the case
of maximum matching. For k-edge and k-vertex connectivity we also give improved
bounds. Additionally we give an insertions-only algorithm for maximum cardinality
matching with worst-case O(n) amortized time per insertion. "
article_processing_charge: No
author:
- first_name: David
full_name: Alberts, David
last_name: Alberts
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Alberts D, Henzinger MH. Average case analysis of dynamic graph algorithms.
In: 6th Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial
and Applied Mathematics; 1995:312-321.'
apa: 'Alberts, D., & Henzinger, M. H. (1995). Average case analysis of dynamic
graph algorithms. In 6th Annual ACM-SIAM Symposium on Discrete Algorithms
(pp. 312–321). San Francisco, CA, United States: Society for Industrial and Applied
Mathematics.'
chicago: Alberts, David, and Monika H Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” In 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
312–21. Society for Industrial and Applied Mathematics, 1995.
ieee: D. Alberts and M. H. Henzinger, “Average case analysis of dynamic graph algorithms,”
in 6th Annual ACM-SIAM Symposium on Discrete Algorithms, San Francisco,
CA, United States, 1995, pp. 312–321.
ista: 'Alberts D, Henzinger MH. 1995. Average case analysis of dynamic graph algorithms.
6th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete
Algorithms, 312–321.'
mla: Alberts, David, and Monika H. Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
Society for Industrial and Applied Mathematics, 1995, pp. 312–21.
short: D. Alberts, M.H. Henzinger, in:, 6th Annual ACM-SIAM Symposium on Discrete
Algorithms, Society for Industrial and Applied Mathematics, 1995, pp. 312–321.
conference:
end_date: 1995-01-24
location: San Francisco, CA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 1995-01-22
date_created: 2022-08-19T07:10:23Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2023-02-21T16:24:58Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://dl.acm.org/doi/10.5555/313651.313712
month: '01'
oa: 1
oa_version: Published Version
page: 312-321
publication: 6th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '0898713498'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
record:
- id: '11680'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Average case analysis of dynamic graph algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1995'
...
---
_id: '3454'
abstract:
- lang: eng
text: The study of gene expression and regulation in the central nervous system
(CNS) is a daunting task because of the diversity of neuronal phenotypes and the
complexity of many protein classes. Molecular cloning revealed the presence of
a large number of different protein families in the CNS, each comprising several
members. Ligand-gated ion channels may serve as an example to illustrate this
point (for review, see Unwin, 1993). Heterologous expression combined with electrophysiological
analysis suggests that ligand-gated channels are multimeric proteins with functional
properties depending on the subunit composition. Very little is known, however,
about how the functional properties of the recombinant and native receptors relate
to each other. Thus, it is of eminent importance to elucidate the subunit expression
profile in different types of neurons in the CNS and to correlate this with the
functional properties of the native receptors.
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Monyer H, Jonas PM. Polymerase chain reaction analysis of ion channel expression
in single neurons of brain slices. In: Sakmann B, Neher E, eds. Single-Channel
Recording. Plenum; 1995:357-373. doi:10.1007/978-1-4419-1229-9_16'
apa: Monyer, H., & Jonas, P. M. (1995). Polymerase chain reaction analysis of
ion channel expression in single neurons of brain slices. In B. Sakmann &
E. Neher (Eds.), Single-channel recording (pp. 357–373). Plenum. https://doi.org/10.1007/978-1-4419-1229-9_16
chicago: Monyer, Hannah, and Peter M Jonas. “Polymerase Chain Reaction Analysis
of Ion Channel Expression in Single Neurons of Brain Slices.” In Single-Channel
Recording, edited by Bert Sakmann and Erwin Neher, 357–73. Plenum, 1995. https://doi.org/10.1007/978-1-4419-1229-9_16.
ieee: H. Monyer and P. M. Jonas, “Polymerase chain reaction analysis of ion channel
expression in single neurons of brain slices,” in Single-channel recording,
B. Sakmann and E. Neher, Eds. Plenum, 1995, pp. 357–373.
ista: 'Monyer H, Jonas PM. 1995.Polymerase chain reaction analysis of ion channel
expression in single neurons of brain slices. In: Single-channel recording. ,
357–373.'
mla: Monyer, Hannah, and Peter M. Jonas. “Polymerase Chain Reaction Analysis of
Ion Channel Expression in Single Neurons of Brain Slices.” Single-Channel Recording,
edited by Bert Sakmann and Erwin Neher, Plenum, 1995, pp. 357–73, doi:10.1007/978-1-4419-1229-9_16.
short: H. Monyer, P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording,
Plenum, 1995, pp. 357–373.
date_created: 2018-12-11T12:03:25Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T09:13:01Z
day: '01'
doi: 10.1007/978-1-4419-1229-9_16
editor:
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Erwin
full_name: Neher, Erwin
last_name: Neher
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4419-1229-9_16
month: '01'
oa_version: None
page: 357 - 373
publication: Single-channel recording
publication_identifier:
isbn:
- 978-0-306-44870-6
publication_status: published
publisher: Plenum
publist_id: '2933'
quality_controlled: '1'
status: public
title: Polymerase chain reaction analysis of ion channel expression in single neurons
of brain slices
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3455'
abstract:
- lang: eng
text: At a synapse, the transmitter is stored in synaptic vesicles and is released
into the synaptic cleft almost instantaneously upon fusion of these vesicles with
the presynaptic membrane. Subsequently, the transmitter diffuses to ligand-gated
ion channels in the postsynaptic density, binds to them, and thereby causes channel
activation. Unfortunately, we have estimates neither of the exact amount of transmitter
in the synaptic vesicle nor of the concentration in the synaptic cleft reaching
the postsynaptic receptors, and in some cases even the identity of the transmitter
is unknown. These questions may be addressed by modeling of release and diffusion.
Such a theoretical approach, however, is based on several assumptions, some of
which lack experimental evidence.
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Jonas PM. Fast application of agonists to isolated membrane patches. In: Sakmann
B, Neher E, eds. Single-Channel Recording. Plenum; 1995:231-243. doi:10.1007/978-1-4419-1229-9_10'
apa: Jonas, P. M. (1995). Fast application of agonists to isolated membrane patches.
In B. Sakmann & E. Neher (Eds.), Single-channel recording (pp. 231–243).
Plenum. https://doi.org/10.1007/978-1-4419-1229-9_10
chicago: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
In Single-Channel Recording, edited by Bert Sakmann and Erwin Neher, 231–43.
Plenum, 1995. https://doi.org/10.1007/978-1-4419-1229-9_10.
ieee: P. M. Jonas, “Fast application of agonists to isolated membrane patches,”
in Single-channel recording, B. Sakmann and E. Neher, Eds. Plenum, 1995,
pp. 231–243.
ista: 'Jonas PM. 1995.Fast application of agonists to isolated membrane patches.
In: Single-channel recording. , 231–243.'
mla: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
Single-Channel Recording, edited by Bert Sakmann and Erwin Neher, Plenum,
1995, pp. 231–43, doi:10.1007/978-1-4419-1229-9_10.
short: P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording, Plenum,
1995, pp. 231–243.
date_created: 2018-12-11T12:03:25Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T08:51:40Z
day: '01'
doi: 10.1007/978-1-4419-1229-9_10
editor:
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Erwin
full_name: Neher, Erwin
last_name: Neher
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4419-1229-9_10
month: '01'
oa_version: None
page: 231 - 243
publication: Single-channel recording
publication_identifier:
isbn:
- 978-0-306-44870-6
publication_status: published
publisher: Plenum
publist_id: '2932'
quality_controlled: '1'
status: public
title: Fast application of agonists to isolated membrane patches
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3461'
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
citation:
ama: Jonas PM, Burnashev N. Molecular mechanisms controlling calcium entry through
AMPA-type glutamate receptor channels. Neuron. 1995;15(5):987-990. doi:10.1016/0896-6273(95)90087-X
apa: Jonas, P. M., & Burnashev, N. (1995). Molecular mechanisms controlling
calcium entry through AMPA-type glutamate receptor channels. Neuron. Elsevier.
https://doi.org/10.1016/0896-6273(95)90087-X
chicago: Jonas, Peter M, and Nail Burnashev. “Molecular Mechanisms Controlling Calcium
Entry through AMPA-Type Glutamate Receptor Channels.” Neuron. Elsevier,
1995. https://doi.org/10.1016/0896-6273(95)90087-X.
ieee: P. M. Jonas and N. Burnashev, “Molecular mechanisms controlling calcium entry
through AMPA-type glutamate receptor channels,” Neuron, vol. 15, no. 5.
Elsevier, pp. 987–990, 1995.
ista: Jonas PM, Burnashev N. 1995. Molecular mechanisms controlling calcium entry
through AMPA-type glutamate receptor channels. Neuron. 15(5), 987–990.
mla: Jonas, Peter M., and Nail Burnashev. “Molecular Mechanisms Controlling Calcium
Entry through AMPA-Type Glutamate Receptor Channels.” Neuron, vol. 15,
no. 5, Elsevier, 1995, pp. 987–90, doi:10.1016/0896-6273(95)90087-X.
short: P.M. Jonas, N. Burnashev, Neuron 15 (1995) 987–990.
date_created: 2018-12-11T12:03:27Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2022-06-28T08:34:36Z
day: '01'
doi: 10.1016/0896-6273(95)90087-X
extern: '1'
external_id:
pmid:
- '7576666'
intvolume: ' 15'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/089662739590087X?via%3Dihub
month: '11'
oa: 1
oa_version: Published Version
page: 987 - 990
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular mechanisms controlling calcium entry through AMPA-type glutamate
receptor channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1995'
...
---
_id: '3478'
abstract:
- lang: eng
text: 1. Properties of dendritic glutamate receptor (GluR) channels were investigated
using fast application of glutamate to outside-out membrane patches isolated from
the apical dendrites of CA3 and CA1 pyramidal neurons in rat hippocampal slices.
CA3 patches were formed (15-76 μm from the soma) in the region of messy fibre
(MF) synapses, and CA1 patches (25-174 μm from the soma) in the region of Schaffer
collateral (SC) innervation. 2. Dual-component responses consisting of a rapidly
rising and decaying component followed by a second, substantially slower, component
were elicited by 1 ms pulses of 1 mM glutamate in the presence of 10 μM glycine
and absence of external Mg2+. The fast component was selectively blocked by 2-5
μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the slow component by 30 μM
D-2-amino-5-phosphonopentanoic acid (D-AP5), suggesting that the fast and slow
components were mediated by the GluR channels of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate
(AMPA) and NMDA type, respectively. The peak amplitude ratio of the NMDA to AMPA
receptor-mediated components varied between 0.03 and 0.62 in patches from both
CA3 and CA1 dendrites. Patches lacking either component were rarely observed.
3. The peak current-voltage (I-V) relationship of the fast component was almost
linear, whereas the I-V relationship of the slow component showed a region of
negative slope in the presence of 1 mM external Mg2+. The reversal potential for
both components was close to 0 mV. 4. Kainate-preferring GluR channels did not
contribute appreciably to the response to glutamate. The responses to 100 ms pulses
of 1 mM glutamate were mimicked by application of 1 mM AMPA, whereas 1 mM kainate
produced much smaller, weakly desensitizing currents. This suggests that the fast
component is primarily mediated by the action of glutamate on AMPA-preferring
receptors. 5. The mean elementary conductance of AMPA receptor channels was about
10 pS, as estimated by non-stationary fluctuation analysis. The permeability of
these channels to Ca2+ was low (~5% of the permeability to Cs+). 6. The elementary
conductance of NMDA receptor channels was larger, with a main conductance state
of about 45 pS. These channels were 3.6 times more permeable to Ca2+ than to Cs+.
7. AMPA receptor-mediated currents activated rapidly in response to 1 ms pulses
of 1 mM glutamate and deactivated with a predominant, fast time constant and a
smaller, slower component (τ1≃2 ms, τ2≃8 ms, contributing ~80 and ~20% to the
total decay amplitude, respectively). Desensitization of the current during a
100 ms pulse was best fitted by two time constants (τ1≃10 ms, ~60%; τ2≃34 ms,
~40%). 8. NMDA receptor-mediated currents in response to 1 ms pulses of 1 mM glutamate
activated and deactivated much more slowly than AMPA receptor-mediated currents.
The time course could be described by a single exponential rising phase (τ≃7 ms)
followed by a double exponential decay (τ1≃200 ms, ~80%; τ2≃1-3 s, ~20%). 9. Mg2+
blocked the NMDA component in a voltage-dependent manner, with a half-maximal
inhibitory concentration (IC50) of 21 μM at -80 mV. At physiological Mg2+ concentrations,
block of the NMDA component could be rapidly relieved with voltage jumps from
negative to positive potentials. Block of the current upon return to negative
potentials occurred almost instantaneously. 10. Zn2+ also selectively-blocked
the NMDA receptor-mediated current with an IC50 of 22 μM, but this block differed
from that of Mg2+ in that it showed little voltage dependence. Rapid application
of Zn2+ together with glutamate produced partial block of the current. More block
was observed if Zn2+ and glutamate were co-applied when NMDA receptor channels
were already open. 11. The functional properties of dendritic GluRs were similar
to those found at the soma. Knowledge of these properties facilitated simulations
investigating the contribution of coactivated AMPA and NMDA receptors to synaptic
depolarization and Ca2+ entry into dendritic spines. Because of its slow deactivation,
the NMDA receptor-mediated current contributes substantially to depolarization
and Ca2+ entry and is susceptible to modulation over a period of seconds, either
by backpropagating action potentials or by the release of Zn2+ from presynaptic
boutons.
acknowledgement: We thank M.Hausser, A.Roth, P.Ruppersberg, and G.Stuart for helpful
discussions and M.H. and G.S. for critically reading the manuscript. We also thank
M.Kaiser for expert technical assistance and F.Helmchen, M.Huke and A.Roth for computer
programming. Financial support from the Alexander von Humboldt Foundation and the
Deutsche Forschungsgemeinschaft (SFB317) is gratefully acknowledged.
article_processing_charge: No
article_type: original
author:
- first_name: Nelson
full_name: Spruston, Nelson
last_name: Spruston
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Spruston N, Jonas PM, Sakmann B. Dendritic glutamate receptor channels in rat
hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology. 1995;482(Pt
2):325-352. doi:10.1113/jphysiol.1995.sp020521
apa: Spruston, N., Jonas, P. M., & Sakmann, B. (1995). Dendritic glutamate receptor
channels in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020521
chicago: Spruston, Nelson, Peter M Jonas, and Bert Sakmann. “Dendritic Glutamate
Receptor Channels in Rat Hippocampal CA3 and CA1 Pyramidal Neurons.” Journal
of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020521.
ieee: N. Spruston, P. M. Jonas, and B. Sakmann, “Dendritic glutamate receptor channels
in rat hippocampal CA3 and CA1 pyramidal neurons,” Journal of Physiology,
vol. 482, no. Pt 2. Wiley-Blackwell, pp. 325–352, 1995.
ista: Spruston N, Jonas PM, Sakmann B. 1995. Dendritic glutamate receptor channels
in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology. 482(Pt
2), 325–352.
mla: Spruston, Nelson, et al. “Dendritic Glutamate Receptor Channels in Rat Hippocampal
CA3 and CA1 Pyramidal Neurons.” Journal of Physiology, vol. 482, no. Pt
2, Wiley-Blackwell, 1995, pp. 325–52, doi:10.1113/jphysiol.1995.sp020521.
short: N. Spruston, P.M. Jonas, B. Sakmann, Journal of Physiology 482 (1995) 325–352.
date_created: 2018-12-11T12:03:32Z
date_published: 1995-01-15T00:00:00Z
date_updated: 2022-06-28T08:08:40Z
day: '15'
doi: 10.1113/jphysiol.1995.sp020521
extern: '1'
external_id:
pmid:
- '7536248'
intvolume: ' 482'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1995.sp020521
month: '01'
oa: 1
oa_version: Published Version
page: 325 - 352
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2909'
quality_controlled: '1'
status: public
title: Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal
neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 482
year: '1995'
...
---
_id: '3479'
abstract:
- lang: eng
text: 1. Glutamate receptor (GluR) channels were studied in basket cells in the
dentate gyrus of rat hippocampal slices. Basket cells were identified by their
location, dendritic morphology and high frequency of action potentials generated
during sustained current injection. 2. Dual-component currents were activated
by fast application of glutamate to outside-out membrane patches isolated from
basket cell somata (10 μM glycine, no external Mg2+). The fast component was selectively
blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), the slow component by
D-2-amino-5-phosphonopentanoic acid (D-AP5). This suggests that the two components
were mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR)/kainate
receptor and N-methyl-D-aspartate receptor (NMDAR) channels, respectively. The
mean ratio of the peak current of the NMDAR component to that of the AMPAR/kainate
receptor component was 0.22 (1 ms pulses of 10 mM glutamate). 3. The AMPAR/kainate
receptor component, which was studied in isolation in the presence of D-AP5, was
identified as AMPAR mediated on the basis of the preferential activation by AMPA
as compared with kainate, the weak desensitization of kainate-activated currents,
the cross-desensitization between AMPA and kainate, and the reduction of desensitization
by cyclothiazide. 4. Deactivation of basket cell AMPARs following 1 ms pulses
of glutamate occurred with a time constant (τ) of 1.2 ± 0.1 ms (mean ± S.E.M.).
During 100 ms glutamate pulses, AMPARs desensitized with a τ of 3.7 ± 0.2 ms.
5. The peak current-voltage (I-V) relation of AMPAR-mediated currents in Na+-rich
extracellular solution showed a reversal potential of -4.0 ± 2.6 mV and was characterized
by a doubly rectifying shape. The conductance of single AMPAR channels was estimated
as 22.6 ± 1.6 pS using non-stationary fluctuation analysis. AMPARs expressed in
hippocampal basket cells mere highly Ca2+ permeable (P(Ca)/P(K) = 1.79). 6. NMDARs
in hippocampal basket cells were studied in isolation in the presence of CNQX.
Deactivation of NMDARs activated by glutamate pulses occurred bi-exponentially
with mean τ values of 266 ± 23 ms (76%) and 2620 ± 383 ms (24%). 7. The peak I-V
relation of the NMDAR-mediated component in Na+-rich extracellular solution showed
a reversal potential of 1.5 ± 0.6 mV and a region of negative slope at negative
membrane potentials in the presence of external Mg2+, due to voltage-dependent
block by these ions. The conductance of single NMDAR channels in the main open
state was 50.2 ± 1.8 pS. NMDARs in hippocampal basket cells were highly permeable
to Ca2+ (P(Ca)/P(K) = 6.68). 8. AMPARs in hippocampal basket cells are characterized
by about threefold faster kinetics and twentyfold higher Ca2+ permeability than
AMPARs in hippocampal granule or pyramidal cells. Simulations show that the Ca2+
influx through basket cell AMPARs is comparable to that through NMDARs at negative
membrane potentials with physiological concentrations of Ca2+ and Mg2+. This suggests
a dual pathway of synaptically mediated Ca2+ entry into interneurones.
acknowledgement: We thank Drs M.Häusser and H.Markram for critically reading the manuscript
and M.Kaiser for technical assistance. Supported by the Deutsche Forschungsgemeinschaft
(SFB-317/B14 grant to P.J. and a Graduiertenkollegstipendium to J.R.P.G.)
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Koh D, Geiger J, Jonas PM, Sakmann B. Ca(2+)-permeable AMPA and NMDA receptor
channels in basket cells of rat hippocampal dentate gyrus. Journal of Physiology.
1995;485(Pt 2):383-402. doi:10.1113/jphysiol.1995.sp020737
apa: Koh, D., Geiger, J., Jonas, P. M., & Sakmann, B. (1995). Ca(2+)-permeable
AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020737
chicago: Koh, Duk, Jörg Geiger, Peter M Jonas, and Bert Sakmann. “Ca(2+)-Permeable
AMPA and NMDA Receptor Channels in Basket Cells of Rat Hippocampal Dentate Gyrus.”
Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020737.
ieee: D. Koh, J. Geiger, P. M. Jonas, and B. Sakmann, “Ca(2+)-permeable AMPA and
NMDA receptor channels in basket cells of rat hippocampal dentate gyrus,” Journal
of Physiology, vol. 485, no. Pt 2. Wiley-Blackwell, pp. 383–402, 1995.
ista: Koh D, Geiger J, Jonas PM, Sakmann B. 1995. Ca(2+)-permeable AMPA and NMDA
receptor channels in basket cells of rat hippocampal dentate gyrus. Journal of
Physiology. 485(Pt 2), 383–402.
mla: Koh, Duk, et al. “Ca(2+)-Permeable AMPA and NMDA Receptor Channels in Basket
Cells of Rat Hippocampal Dentate Gyrus.” Journal of Physiology, vol. 485,
no. Pt 2, Wiley-Blackwell, 1995, pp. 383–402, doi:10.1113/jphysiol.1995.sp020737.
short: D. Koh, J. Geiger, P.M. Jonas, B. Sakmann, Journal of Physiology 485 (1995)
383–402.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-28T07:54:44Z
day: '01'
doi: 10.1113/jphysiol.1995.sp020737
extern: '1'
external_id:
pmid:
- '7545230'
intvolume: ' 485'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1158000/pdf/jphysiol00319-0104.pdf
month: '06'
oa: 1
oa_version: Published Version
page: 383 - 402
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2908'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal
dentate gyrus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 485
year: '1995'
...
---
_id: '3480'
abstract:
- lang: eng
text: Recording of glutamate-activated currents in membrane patches was combine
with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified
cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons
of hippocampus and neocortex and in auditory relay neurons and Bergmann glial
cells indicates that the GluR-B subunit in its flip version determines formation
of receptors with relatively slow gating, whereas the GluR-D subunit promotes
assembly of more rapidly gated receptors. The relation between Ca 2+ permeability
of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the
dominance of this subunit in determining the Ca 2+ permeability of native receptors.
The results suggest that differential expression of GluR-B and GluR-D subunit
genes, as well as splicing end editing of their mRNAs, account for the differences
in gating and Ca 2+ permeability of native AMPAR channels.
acknowledgement: "We thank Ulla Amtmann for efficient help with the molecular analysis.
We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice
concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for
critically reading the manuscript. Funded in part by Bundesministerium für Forschung
und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant
SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program
of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs
of publication of this article were defrayed in part by the payment of page charges.
This article must therefore be hereby\r\nmarked “advertisement” in accordance with
18 USC Section 1734 solely to Indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Thorsten
full_name: Melcher, Thorsten
last_name: Melcher
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
citation:
ama: Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines
gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4
apa: Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., &
Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+)
permeability of AMPA receptors in principal neurons and interneurons in rat CNS.
Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4
chicago: Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter
M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4.
ieee: J. Geiger et al., “Relative abundance of subunit mRNAs determines gating
and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995.
ista: Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995.
Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1),
193–204.
mla: Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4.
short: J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer,
Neuron 15 (1995) 193–204.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2022-06-28T07:47:09Z
day: '01'
doi: 10.1016/0896-6273(95)90076-4
extern: '1'
external_id:
pmid:
- '7619522'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub
month: '07'
oa: 1
oa_version: Published Version
page: 193 - 204
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1995'
...
---
_id: '3481'
abstract:
- lang: eng
text: 1. The influence of intracellular factors on current rectification of different
subtypes of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
(AMPARs) was studied in rat brain slices by combining fast application of glutamate
with patch pipette perfusion. 2. The peak current-voltage (I-V) relation of the
AMPARs expressed in Bergmann glial cells of cerebellum and dentate gyrus (DG)
basket cells of hippocampus was weakly rectifying in outside-out patches and nystatin-perforated
vesicles, but showed a doubly rectifying shape with a region of reduced slope
between 0 and +40 mV in nucleated patches. The I-V relation of AMPARs expressed
in hippocampal CA3 pyramidal neurones was linear in all recording configurations.
3. Intracellular application of 2.5 μM spermine, a naturally occurring polyamine,
blocked outward currents in outside-oat patches from Bergmann glial cells and
DG basket cells in a voltage-dependent manner, generating I-V relations with a
doubly rectifying shape which were similar to those recorded in nucleated patches.
AMPARs in CA3 pyramidal cell patches were unaffected by 25 μM spermine. 4. The
half-maximal blocking concentration of spermine at +40 mV was 0.3 μM in Bergmann
glial cell patches and 1.5 μM in DG basket cell patches, whereas it was much higher
(≥ 100 μM) for CA3 pyramidal. cell patches. Spermidine also affected current rectification,
but with lower affinity. The block of outward current by polyamines following
voltage jumps developed within < 0.5 ms. 5. We conclude that current rectification,
rather than being an intrinsic property of the Ca2+ permeable AMPAR channel, is
generated by polyamine block.
acknowledgement: We thank Dr B.Sakmann, Dr V.Witzemann, J.Geiger, and A.Roth for helpful
discussions and Dr D.Feldmeyer and Dr A.Villarroel for reading the manuscript. We
also thank M.Kaiser for technical and H.Spiegel for secretarial assistance. Supported
by DFG grant SFB-317/B14(P.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Koh D, Burnashev N, Jonas PM. Block of native Ca(2+)-permeable AMPA receptors
in rat brain by intracellular polyamines generates double rectification. Journal
of Physiology. 1995;486(Pt 2):305-312. doi:10.1113/jphysiol.1995.sp020813
apa: Koh, D., Burnashev, N., & Jonas, P. M. (1995). Block of native Ca(2+)-permeable
AMPA receptors in rat brain by intracellular polyamines generates double rectification.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020813
chicago: Koh, Duk, Nail Burnashev, and Peter M Jonas. “Block of Native Ca(2+)-Permeable
AMPA Receptors in Rat Brain by Intracellular Polyamines Generates Double Rectification.”
Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020813.
ieee: D. Koh, N. Burnashev, and P. M. Jonas, “Block of native Ca(2+)-permeable AMPA
receptors in rat brain by intracellular polyamines generates double rectification,”
Journal of Physiology, vol. 486, no. Pt 2. Wiley-Blackwell, pp. 305–312,
1995.
ista: Koh D, Burnashev N, Jonas PM. 1995. Block of native Ca(2+)-permeable AMPA
receptors in rat brain by intracellular polyamines generates double rectification.
Journal of Physiology. 486(Pt 2), 305–312.
mla: Koh, Duk, et al. “Block of Native Ca(2+)-Permeable AMPA Receptors in Rat Brain
by Intracellular Polyamines Generates Double Rectification.” Journal of Physiology,
vol. 486, no. Pt 2, Wiley-Blackwell, 1995, pp. 305–12, doi:10.1113/jphysiol.1995.sp020813.
short: D. Koh, N. Burnashev, P.M. Jonas, Journal of Physiology 486 (1995) 305–312.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-07-15T00:00:00Z
date_updated: 2022-06-27T14:53:16Z
day: '15'
doi: 10.1113/jphysiol.1995.sp020813
extern: '1'
external_id:
pmid:
- '7473198'
intvolume: ' 486'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156754/
month: '07'
oa: 1
oa_version: Published Version
page: 305 - 312
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2906'
quality_controlled: '1'
status: public
title: Block of native Ca(2+)-permeable AMPA receptors in rat brain by intracellular
polyamines generates double rectification
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 486
year: '1995'
...
---
_id: '3551'
abstract:
- lang: eng
text: Common geometric models for proteins and other molecules are the space filling
diagram, the solvent accessible surface, and the molecular surface. We describe
software that computes metric properties of these models, including volume and
surface area. It also measures voids or empty space enclosed by the protein, and
it keeps track of surface area contributions of individual atoms. The software
is based on 3-dimensional alpha complexes and on inclusion-exclusion formulas
with terms derived from the simplices in this complex.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Facello, Michael
last_name: Facello
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
citation:
ama: 'Edelsbrunner H, Facello M, Fu P, Liang J. Measuring proteins and voids in
proteins. In: Proceedings of the 28th Annual Hawaii International Conference
on System Sciences. IEEE; 1995:256-264. doi:10.1109/HICSS.1995.375331'
apa: 'Edelsbrunner, H., Facello, M., Fu, P., & Liang, J. (1995). Measuring proteins
and voids in proteins. In Proceedings of the 28th Annual Hawaii International
Conference on System Sciences (pp. 256–264). Wailea, HI, United States of
America: IEEE. https://doi.org/10.1109/HICSS.1995.375331'
chicago: Edelsbrunner, Herbert, Michael Facello, Ping Fu, and Jie Liang. “Measuring
Proteins and Voids in Proteins.” In Proceedings of the 28th Annual Hawaii International
Conference on System Sciences, 256–64. IEEE, 1995. https://doi.org/10.1109/HICSS.1995.375331.
ieee: H. Edelsbrunner, M. Facello, P. Fu, and J. Liang, “Measuring proteins and
voids in proteins,” in Proceedings of the 28th Annual Hawaii International
Conference on System Sciences, Wailea, HI, United States of America, 1995,
pp. 256–264.
ista: 'Edelsbrunner H, Facello M, Fu P, Liang J. 1995. Measuring proteins and voids
in proteins. Proceedings of the 28th Annual Hawaii International Conference on
System Sciences. HICSS: Hawaii International Conference on System Sciences, 256–264.'
mla: Edelsbrunner, Herbert, et al. “Measuring Proteins and Voids in Proteins.” Proceedings
of the 28th Annual Hawaii International Conference on System Sciences, IEEE,
1995, pp. 256–64, doi:10.1109/HICSS.1995.375331.
short: H. Edelsbrunner, M. Facello, P. Fu, J. Liang, in:, Proceedings of the 28th
Annual Hawaii International Conference on System Sciences, IEEE, 1995, pp. 256–264.
conference:
end_date: 1995-01-06
location: Wailea, HI, United States of America
name: 'HICSS: Hawaii International Conference on System Sciences'
start_date: 1995-01-03
date_created: 2018-12-11T12:03:55Z
date_published: 1995-01-04T00:00:00Z
date_updated: 2022-06-27T13:54:41Z
day: '04'
doi: 10.1109/HICSS.1995.375331
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/375331
month: '01'
oa_version: None
page: 256 - 264
publication: Proceedings of the 28th Annual Hawaii International Conference on System
Sciences
publication_identifier:
isbn:
- 0-8186-6930-6
publication_status: published
publisher: IEEE
publist_id: '2834'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Measuring proteins and voids in proteins
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3552'
abstract:
- lang: eng
text: "The concept of an α-shape of a finite set of points in R^d, with weights,
is defined and illustrated. An α-shape is a polytope which is not necessarily
convex nor connected and can be derived from the (weighted) Delaunay triangulation
of the point set, with a parameter controlling the desired level of detail. The
set of all α values leads to a descrete family of shapes capturing the intuitive
notion of ``crude'' versus ``fine'' shapes of a point set. Software that computes
such shapes in R^2 and R^3 is available via anonymous ftp from:\r\n\r\nftp://ftp.ncsa.uiuc.edu/Visualization/Alpha-shape/
\ "
article_processing_charge: No
author:
- first_name: Nataraj
full_name: Akkiraju, Nataraj
last_name: Akkiraju
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Facello, Michael
last_name: Facello
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
- first_name: Ernst
full_name: Mücke, Ernst
last_name: Mücke
- first_name: Carlos
full_name: Varela, Carlos
last_name: Varela
citation:
ama: 'Akkiraju N, Edelsbrunner H, Facello M, Fu P, Mücke E, Varela C. Alpha shapes:
definition and software. In: Elsevier; 1995:63-66.'
apa: 'Akkiraju, N., Edelsbrunner, H., Facello, M., Fu, P., Mücke, E., & Varela,
C. (1995). Alpha shapes: definition and software (pp. 63–66). Presented at the
GCG: International Computational Geometry Software Workshop, Elsevier.'
chicago: 'Akkiraju, Nataraj, Herbert Edelsbrunner, Michael Facello, Ping Fu, Ernst
Mücke, and Carlos Varela. “Alpha Shapes: Definition and Software,” 63–66. Elsevier,
1995.'
ieee: 'N. Akkiraju, H. Edelsbrunner, M. Facello, P. Fu, E. Mücke, and C. Varela,
“Alpha shapes: definition and software,” presented at the GCG: International Computational
Geometry Software Workshop, 1995, pp. 63–66.'
ista: 'Akkiraju N, Edelsbrunner H, Facello M, Fu P, Mücke E, Varela C. 1995. Alpha
shapes: definition and software. GCG: International Computational Geometry Software
Workshop, 63–66.'
mla: 'Akkiraju, Nataraj, et al. Alpha Shapes: Definition and Software. Elsevier,
1995, pp. 63–66.'
short: N. Akkiraju, H. Edelsbrunner, M. Facello, P. Fu, E. Mücke, C. Varela, in:,
Elsevier, 1995, pp. 63–66.
conference:
name: 'GCG: International Computational Geometry Software Workshop'
date_created: 2018-12-11T12:03:55Z
date_published: 1995-09-11T00:00:00Z
date_updated: 2022-06-27T13:20:29Z
day: '11'
extern: '1'
language:
- iso: eng
main_file_link:
- url: http://www.geom.uiuc.edu/software/cglist/GeomDir/shapes95def/
month: '09'
oa_version: None
page: 63 - 66
publication_status: published
publisher: Elsevier
publist_id: '2833'
quality_controlled: '1'
status: public
title: 'Alpha shapes: definition and software'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3597'
article_processing_charge: No
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Barton NH. Déjà vu all over again. Nature. 1995;377:388-389.
doi:10.1038/377388a0
apa: Kirkpatrick, M., & Barton, N. H. (1995). Déjà vu all over again. Nature.
Nature Publishing Group. https://doi.org/10.1038/377388a0
chicago: Kirkpatrick, Mark, and Nicholas H Barton. “Déjà vu All over Again.” Nature.
Nature Publishing Group, 1995. https://doi.org/10.1038/377388a0.
ieee: M. Kirkpatrick and N. H. Barton, “Déjà vu all over again,” Nature,
vol. 377. Nature Publishing Group, pp. 388–389, 1995.
ista: Kirkpatrick M, Barton NH. 1995. Déjà vu all over again. Nature. 377, 388–389.
mla: Kirkpatrick, Mark, and Nicholas H. Barton. “Déjà vu All over Again.” Nature,
vol. 377, Nature Publishing Group, 1995, pp. 388–89, doi:10.1038/377388a0.
short: M. Kirkpatrick, N.H. Barton, Nature 377 (1995) 388–389.
date_created: 2018-12-11T12:04:09Z
date_published: 1995-10-05T00:00:00Z
date_updated: 2022-06-27T13:00:10Z
day: '05'
doi: 10.1038/377388a0
extern: '1'
external_id:
pmid:
- '7566112 '
intvolume: ' 377'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/377388a0
month: '10'
oa_version: None
page: 388 - 389
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '2786'
quality_controlled: '1'
status: public
title: Déjà vu all over again
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 377
year: '1995'
...
---
_id: '3636'
abstract:
- lang: eng
text: 'Observations on the means, variances, and covariances of quantitative traits
across hybrid zones can give information similar to that from Mendelian markers.
In addition, they can identify particular traits through which the cline is maintained.
We describe a survey of six traits across the hybrid zone between Bombina bombina
and Bombina variegata (Amphibia: Discoglossidae) near Pescenica in Croatia. We
obtained laboratory measuments of the belly pattern, skin thickness, mating call,
skeletal form, egg size, and the developmental time of tadpoles. Although offspring
from hybrid populations showed no evidence of reduced viability, a third of the
F1 families failed completely, irrespective of the direction of the cross. All
traits differed significantly between the taxa. Clines in belly pattern, skin
thickness, mating call, and skeletal form were closely concordant with clines
in four diagnostic enzyme loci. However, the cline in developmental time was displaced
towards bombina, and the cline in egg size was displaced towards variegata. This
discordance could be because the traits are not inherited additively or because
they are subject to different selection pressures. We favor the latter explanation
in the case of developmental time. We show that moderate selection acting directly
on a trait suffices to shift its position; rather stronger selection is needed
to change its width appreciably. Within hybrid populations, there are significant
associations among quantitative traits, and between traits and enzymes. Phenotypic
variances also increase in hybrid populations. These observations can be explained
by linkage disequilibria among the underlying loci. However, the average magnitude
of the covariance between traits is about half that expected from the linkage
disequilibria between enzyme loci. The discrepancy is not readily explained by
nonadditive gene action. This puzzle is now unresolved and calls for further investigation.'
acknowledgement: 'The project would not have been possible without F. Perovic''s extensive
knowledge of the natural history of the Pegdenica area, and his assistance in the
field. Particular thanks are due to the Perovie family for their generous hospitality.
The Croatian Museum of Natural History and the Croatian Ministry of the Environment
were helpful in granting all the necessary permits. J. Szymura assisted with allozyme
tech-niques and in sharing unpublished data from his original survey of the area.
M. Davidson and K. Grant prepared the histological specimens, and G. Patterson volunteered
time and expertise in X-raying our toads. All members of L. Partridge''s lab generously
provided us with toad food on a daily basis, in the form of uncountably many spare
Drosophila. G. Malarky and M. Oh stoically coped with much tedious toad care. We
thank W. G. Hill, L. Kruuk, D. Rand, J. Szymura, and an anonymous reviewer for helpful
comments on the manuscript. This research was supported by a grant from the Natural
Environment Research Council (GR3/8002) to N.B. '
article_processing_charge: No
article_type: original
author:
- first_name: Beate
full_name: Nürnberger, Beate
last_name: Nürnberger
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Catriona
full_name: Maccallum, Catriona
last_name: Maccallum
- first_name: Jason
full_name: Gilchrist, Jason
last_name: Gilchrist
- first_name: Michael
full_name: Appleby, Michael
last_name: Appleby
citation:
ama: Nürnberger B, Barton NH, Maccallum C, Gilchrist J, Appleby M. Natural selection
on quantitative traits in the Bombina hybrid zone. Evolution. 1995;49(6):1224-1238.
doi:10.1111/j.1558-5646.1995.tb04449.x
apa: Nürnberger, B., Barton, N. H., Maccallum, C., Gilchrist, J., & Appleby,
M. (1995). Natural selection on quantitative traits in the Bombina hybrid zone.
Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1995.tb04449.x
chicago: Nürnberger, Beate, Nicholas H Barton, Catriona Maccallum, Jason Gilchrist,
and Michael Appleby. “Natural Selection on Quantitative Traits in the Bombina
Hybrid Zone.” Evolution. Wiley-Blackwell, 1995. https://doi.org/10.1111/j.1558-5646.1995.tb04449.x.
ieee: B. Nürnberger, N. H. Barton, C. Maccallum, J. Gilchrist, and M. Appleby, “Natural
selection on quantitative traits in the Bombina hybrid zone,” Evolution,
vol. 49, no. 6. Wiley-Blackwell, pp. 1224–1238, 1995.
ista: Nürnberger B, Barton NH, Maccallum C, Gilchrist J, Appleby M. 1995. Natural
selection on quantitative traits in the Bombina hybrid zone. Evolution. 49(6),
1224–1238.
mla: Nürnberger, Beate, et al. “Natural Selection on Quantitative Traits in the
Bombina Hybrid Zone.” Evolution, vol. 49, no. 6, Wiley-Blackwell, 1995,
pp. 1224–38, doi:10.1111/j.1558-5646.1995.tb04449.x.
short: B. Nürnberger, N.H. Barton, C. Maccallum, J. Gilchrist, M. Appleby, Evolution
49 (1995) 1224–1238.
date_created: 2018-12-11T12:04:22Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-27T12:58:02Z
day: '01'
doi: 10.1111/j.1558-5646.1995.tb04449.x
extern: '1'
intvolume: ' 49'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1995.tb04449.x
month: '12'
oa: 1
oa_version: Published Version
page: 1224 - 1238
publication: Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2747'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural selection on quantitative traits in the Bombina hybrid zone
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1995'
...
---
_id: '3637'
abstract:
- lang: eng
text: 'Hybridizing taxa remain distinct for two main reasons. Natural selection
acts against hybrids either because of their incompatible genome, or because of
differential adaptation of the pure types across an environmental gradient. Here,
we provide experimental evidence that the location of the Bombina (Anura: Discoglossidae)
hybrid zone in Croatia is, at least in part, determined by differential adaptation.
B. bombina typically breeds in permanent water in the lowland, whereas B. variegata
reproduces in puddles at higher elevations. In a reciprocal translocation, pure
bombina and variegata tadpoles were introduced in equal proportions into lowland
pond enclosures and upland puddles. After three weeks, variegata exceeded bombina
in survival and growth in both habitats. The effect was most pronounced in puddles,
where the few surviving bombina tadpoles had hardly grown at all. In comparison
to variegata, the smaller hatchlings of bombina grew relatively faster in ponds,
but remained smaller in absolute terms. Nevertheless, B. bombina appears better
adapted to ponds than to puddles. The mechanisms by which variegata is excluded
from ponds remain to be demonstrated. These data show that habitat dependent selection
prevents the invasion of bombina tadpole traits into the variegata gene pool.
Given the strong linkage disequilibria in hybrid populations, differential selection
on tadpoles may be sufficient to maintain the integrity of the two gene pools.'
acknowledgement: We thank Franjo Perovioc for invaluable help in the field and the Perovioc
family for generous hospitality. Logistical and practical support was provided by the Croatian
Museum of Natural History in particular Bojan Lazar and Eduarrd Kletecki. The people
of Velesevec kindly tolerated our enclosure bags in their village pond. Stejpan
Ticeric generously provided a base for our work in Perkovec. Professor S. Jelaska of
the U niversity of Zagreb allowed us unlim ited access to her laboratory, where all tadpole
m easurem ents were taken. Loeske K ruuk carried out the electrophoretic analysis which established the taxonomic
significance of tadpole belly colour. We thank Ian Wilson for statistical advice
and Tim Halliday, Peter Jones, Loeske Kruuk, Jaroslav Pialek and two anonymous
referees for helpful comments on the manuscript. This research was supported by
a grant from the NERC (No. GR3/8002) to N.H.B.
article_processing_charge: No
article_type: original
author:
- first_name: Catriona
full_name: Maccallum, Catriona
last_name: Maccallum
- first_name: Beate
full_name: Nürnberger, Beate
last_name: Nürnberger
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Maccallum C, Nürnberger B, Barton NH. Experimental evidence for habitat dependent
selection in a Bombina hybrid zone. Proceedings of the Royal Society of London
Series B Biological Sciences. 1995;260(1359):257-264. doi:10.1098/rspb.1995.0089
apa: Maccallum, C., Nürnberger, B., & Barton, N. H. (1995). Experimental evidence
for habitat dependent selection in a Bombina hybrid zone. Proceedings of the
Royal Society of London Series B Biological Sciences. Royal Society of London.
https://doi.org/10.1098/rspb.1995.0089
chicago: Maccallum, Catriona, Beate Nürnberger, and Nicholas H Barton. “Experimental
Evidence for Habitat Dependent Selection in a Bombina Hybrid Zone.” Proceedings
of the Royal Society of London Series B Biological Sciences. Royal Society
of London, 1995. https://doi.org/10.1098/rspb.1995.0089.
ieee: C. Maccallum, B. Nürnberger, and N. H. Barton, “Experimental evidence for
habitat dependent selection in a Bombina hybrid zone,” Proceedings of the Royal
Society of London Series B Biological Sciences, vol. 260, no. 1359. Royal
Society of London, pp. 257–264, 1995.
ista: Maccallum C, Nürnberger B, Barton NH. 1995. Experimental evidence for habitat
dependent selection in a Bombina hybrid zone. Proceedings of the Royal Society
of London Series B Biological Sciences. 260(1359), 257–264.
mla: Maccallum, Catriona, et al. “Experimental Evidence for Habitat Dependent Selection
in a Bombina Hybrid Zone.” Proceedings of the Royal Society of London Series
B Biological Sciences, vol. 260, no. 1359, Royal Society of London, 1995,
pp. 257–64, doi:10.1098/rspb.1995.0089.
short: C. Maccallum, B. Nürnberger, N.H. Barton, Proceedings of the Royal Society
of London Series B Biological Sciences 260 (1995) 257–264.
date_created: 2018-12-11T12:04:22Z
date_published: 1995-06-22T00:00:00Z
date_updated: 2022-06-27T10:14:02Z
day: '22'
doi: 10.1098/rspb.1995.0089
extern: '1'
intvolume: ' 260'
issue: '1359'
language:
- iso: eng
main_file_link:
- url: https://royalsocietypublishing.org/doi/10.1098/rspb.1995.0089
month: '06'
oa_version: None
page: 257 - 264
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: Royal Society of London
publist_id: '2746'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Experimental evidence for habitat dependent selection in a Bombina hybrid zone
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 260
year: '1995'
...
---
_id: '3638'
abstract:
- lang: eng
text: 'Any sample of genes traces back to a single common ancestor. Each gene also
has other properties: its sequence, its geographic location and the phenotype
and fitness of the organism that carries it. With sexual reproduction, different
genes have different genealogies, which gives us much more information, but also
greatly complicates population genetic analysis. We review the close relation
between the distribution of genealogies and the classic theory of identity by
descent in spatially structured populations, and develop a simple diffusion approximation
to the distribution of coalescence times in a homogeneous two-dimensional habitat.
This shows that when neighbourhood size is large (as in most populations) only
a small fraction of pairs of genes are closely related, and only this fraction
gives information about current rates of gene flow. The increase of spatial dispersion
with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy
depends on the long-term history of the population; we discuss ways of inferring
this history from the concordance between genealogies across loci.'
acknowledgement: This work was supported by BBSRC grant GR/H/09928 and by a Scottish Office studentship. We thank A.
W. F. Edwards and S. Otto for their helpful comments.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: I
full_name: Wilson, I
last_name: Wilson
citation:
ama: Barton NH, Wilson I. Genealogies and geography. Philosophical Transactions
of the Royal Society of London Series B, Biological Sciences. 1995;349(1327):49-59.
doi:10.1098/rstb.1995.0090
apa: Barton, N. H., & Wilson, I. (1995). Genealogies and geography. Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences.
Royal Society, The. https://doi.org/10.1098/rstb.1995.0090
chicago: Barton, Nicholas H, and I Wilson. “Genealogies and Geography.” Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences.
Royal Society, The, 1995. https://doi.org/10.1098/rstb.1995.0090.
ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences,
vol. 349, no. 1327. Royal Society, The, pp. 49–59, 1995.
ista: Barton NH, Wilson I. 1995. Genealogies and geography. Philosophical Transactions
of the Royal Society of London. Series B, Biological Sciences. 349(1327), 49–59.
mla: Barton, Nicholas H., and I. Wilson. “Genealogies and Geography.” Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences,
vol. 349, no. 1327, Royal Society, The, 1995, pp. 49–59, doi:10.1098/rstb.1995.0090.
short: N.H. Barton, I. Wilson, Philosophical Transactions of the Royal Society of
London. Series B, Biological Sciences 349 (1995) 49–59.
date_created: 2018-12-11T12:04:22Z
date_published: 1995-07-29T00:00:00Z
date_updated: 2022-06-27T08:55:07Z
day: '29'
doi: 10.1098/rstb.1995.0090
extern: '1'
external_id:
pmid:
- '8748019'
intvolume: ' 349'
issue: '1327'
language:
- iso: eng
main_file_link:
- url: https://royalsocietypublishing.org/doi/10.1098/rstb.1995.0090
month: '07'
oa_version: None
page: 49 - 59
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society, The
publist_id: '2745'
quality_controlled: '1'
status: public
title: Genealogies and geography
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 349
year: '1995'
...
---
_id: '3639'
abstract:
- lang: eng
text: 'A general representation of multilocus selection is extended to allow recombination
to depend on genotype. The equations simplify if modifier alleles have small effects
on recombination. The evolution of such modifiers only depends on how they alter
recombination between the selected loci, and does not involve dominance in modifier
effects. The net selection on modifiers can be found explicitly if epistasis is
weak relative to recombination. This analysis shows that recombination can be
favoured in two ways: because it impedes the response to epistasis which fluctuates
in sign, or because it facilitates the response to directional selection. The
first mechanism is implausible, because epistasis must change sign over periods
of a few generations: faster or slower fluctuations favour reduced recombination.
The second mechanism requires weak negative epistasis between favourable alleles,
which may either be increasing, or held in check by mutation. The selection (si)
on recombination modifiers depends on the reduction in additive variance of log
(fitness) due to linkage disequilibria (υ1 < 0), and on non-additive variance
in log (fitness) (V′2, V′3,.. epistasis between 2, 3.. loci). For unlinked loci
and pairwise epistasis, si = − (υ1 + 4V2/3)δr, where δr is the average increase
in recombination caused by the modifier. The approximations are checked against
exact calculations for three loci, and against Charlesworth''s analyses of mutation/selection
balance (1990), and directional selection (1993). The analysis demonstrates a
general relation between selection on recombination and observable components
of fitness variation, which is open to experimental test.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. A general model for the evolution of recombination. Genetical
Research. 1995;65(2):123-144. doi:10.1017/S0016672300033140
apa: Barton, N. H. (1995). A general model for the evolution of recombination. Genetical
Research. Cambridge University Press. https://doi.org/10.1017/S0016672300033140
chicago: Barton, Nicholas H. “A General Model for the Evolution of Recombination.”
Genetical Research. Cambridge University Press, 1995. https://doi.org/10.1017/S0016672300033140.
ieee: N. H. Barton, “A general model for the evolution of recombination,” Genetical
Research, vol. 65, no. 2. Cambridge University Press, pp. 123–144, 1995.
ista: Barton NH. 1995. A general model for the evolution of recombination. Genetical
Research. 65(2), 123–144.
mla: Barton, Nicholas H. “A General Model for the Evolution of Recombination.” Genetical
Research, vol. 65, no. 2, Cambridge University Press, 1995, pp. 123–44, doi:10.1017/S0016672300033140.
short: N.H. Barton, Genetical Research 65 (1995) 123–144.
date_created: 2018-12-11T12:04:23Z
date_published: 1995-04-01T00:00:00Z
date_updated: 2022-06-24T11:54:10Z
day: '01'
doi: 10.1017/S0016672300033140
extern: '1'
external_id:
pmid:
- '7605514'
intvolume: ' 65'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/general-model-for-the-evolution-of-recombination/8CBDDF2DC779CF4B6AE9B461B80BB4AE
month: '04'
oa_version: None
page: 123 - 144
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2744'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A general model for the evolution of recombination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 65
year: '1995'
...
---
_id: '3640'
abstract:
- lang: eng
text: 'The probability of fixation of a favorable mutation is reduced if selection
at other loci causes inherited variation in fitness. A general method for calculating
the fixation probability of an allele that can find itself in a variety of genetic
backgrounds is applied to find the effect of substitutions, fluctuating polymorphisms,
and deleterious mutations in a large population. With loose linkage, r, the effects
depend on the additive genetic variance in relative fitness, var(W), and act by
reducing effective population size by (N/Ne) = 1 + var(W)/2r2. However, tightly
linked loci can have a substantial effect not predictable from Ne. Linked deleterious
mutations reduce the fixation probability of weakly favored alleles by exp (-2U/R),
where U is the total mutation rate and R is the map length in Morgans. Substitutions
can cause a greater reduction: an allele with advantage s < scrit = (pi 2/6)
loge (S/s) [var(W)/R] is very unlikely to be fixed. (S is the advantage of the
substitution impeding fixation.) Fluctuating polymorphisms at many (n) linked
loci can also have a substantial effect, reducing fixation probability by exp
[square root of 2Kn var(W)/R] [K = -1/E((u-u)2/uv) depending on the frequencies
(u,v) at the selected polymorphisms]. Hitchhiking due to all three kinds of selection
may substantially impede adaptation that depends on weakly favored alleles.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Linkage and the limits to natural selection. Genetics. 1995;140(2):821-841.
doi:http://www.genetics.org/content/140/2/821.long
apa: Barton, N. H. (1995). Linkage and the limits to natural selection. Genetics.
Genetics Society of America. http://www.genetics.org/content/140/2/821.long
chicago: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics.
Genetics Society of America, 1995. http://www.genetics.org/content/140/2/821.long.
ieee: N. H. Barton, “Linkage and the limits to natural selection,” Genetics,
vol. 140, no. 2. Genetics Society of America, pp. 821–841, 1995.
ista: Barton NH. 1995. Linkage and the limits to natural selection. Genetics. 140(2),
821–841.
mla: Barton, Nicholas H. “Linkage and the Limits to Natural Selection.” Genetics,
vol. 140, no. 2, Genetics Society of America, 1995, pp. 821–41, doi:http://www.genetics.org/content/140/2/821.long.
short: N.H. Barton, Genetics 140 (1995) 821–841.
date_created: 2018-12-11T12:04:23Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-24T09:59:08Z
day: '01'
doi: http://www.genetics.org/content/140/2/821.long
extern: '1'
external_id:
pmid:
- '7498757'
intvolume: ' 140'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206655/
month: '06'
oa: 1
oa_version: Published Version
page: 821 - 841
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2743'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linkage and the limits to natural selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 140
year: '1995'
...
---
_id: '4028'
abstract:
- lang: eng
text: Efficient algorithms are described for computing topological, combinatorial,
and metric properties of the union of finitely many spherical balls in R(d) These
algorithms are based on a simplicial complex dual to a decomposition of the union
of balls using Voronoi cells, and on short inclusion-exclusion formulas derived
from this complex. The algorithms are most relevant in R(3) where unions of finitely
many balls are commonly used as models of molecules.
acknowledgement: This work is supported by the National Science Foundation, under
Grant ASC-9200301, and the Alan T. Waterman award, Grant CCR-9118874. Any opinions,
findings, conclusions, or recommendations expressed in this publication are those
of the author and do not necessarily reflect the view of the National Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. The union of balls and its dual shape. Discrete & Computational
Geometry. 1995;13(1):415-440. doi:10.1007/BF02574053
apa: Edelsbrunner, H. (1995). The union of balls and its dual shape. Discrete
& Computational Geometry. Springer. https://doi.org/10.1007/BF02574053
chicago: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete
& Computational Geometry. Springer, 1995. https://doi.org/10.1007/BF02574053.
ieee: H. Edelsbrunner, “The union of balls and its dual shape,” Discrete &
Computational Geometry, vol. 13, no. 1. Springer, pp. 415–440, 1995.
ista: Edelsbrunner H. 1995. The union of balls and its dual shape. Discrete &
Computational Geometry. 13(1), 415–440.
mla: Edelsbrunner, Herbert. “The Union of Balls and Its Dual Shape.” Discrete
& Computational Geometry, vol. 13, no. 1, Springer, 1995, pp. 415–40,
doi:10.1007/BF02574053.
short: H. Edelsbrunner, Discrete & Computational Geometry 13 (1995) 415–440.
date_created: 2018-12-11T12:06:31Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-27T08:14:48Z
day: '01'
doi: 10.1007/BF02574053
extern: '1'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://link.springer.com/article/10.1007/BF02574053
month: '12'
oa: 1
oa_version: Published Version
page: 415 - 440
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2095'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The union of balls and its dual shape
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1995'
...