---
_id: '2560'
abstract:
- lang: eng
text: Chemical irritation of the urinary bladder with formalin in the rat induced
c-fos protein-like immunoreactivity in more than 80% of substance P receptor-like
immunoreactive (SPR-LI) neurons of the dorsal commissural nucleus, sacral parasympathetic
nucleus and lamina I in the 6th lumbar and 1st sacral cord segments. These neurons
with SPR-LI may receive noxious information from the urinary bladder through the
primary afferent fibers with substance P.
article_processing_charge: No
article_type: original
author:
- first_name: Yan
full_name: Lü, Yan
last_name: Lü
- first_name: Shan
full_name: Jin, Shan
last_name: Jin
- first_name: Tian
full_name: Xu, Tian
last_name: Xu
- first_name: Bing
full_name: Qin, Bing
last_name: Qin
- first_name: Ji
full_name: Li, Ji
last_name: Li
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Lü Y, Jin S, Xu T, et al. Expression of c-fos protein in substance P receptor-like
immunoreactive neurons in response to noxious stimuli on the urinary bladder:
an observation in the lumbosacral cord segments of the rat. Neuroscience Letters.
1995;198(2):139-142. doi:10.1016/0304-3940(95)11991-5'
apa: 'Lü, Y., Jin, S., Xu, T., Qin, B., Li, J., Ding, Y., … Mizuno, N. (1995). Expression
of c-fos protein in substance P receptor-like immunoreactive neurons in response
to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord
segments of the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)11991-5'
chicago: 'Lü, Yan, Shan Jin, Tian Xu, Bing Qin, Ji Li, Yu Ding, Ryuichi Shigemoto,
and Noboru Mizuno. “Expression of C-Fos Protein in Substance P Receptor-like Immunoreactive
Neurons in Response to Noxious Stimuli on the Urinary Bladder: An Observation
in the Lumbosacral Cord Segments of the Rat.” Neuroscience Letters. Elsevier,
1995. https://doi.org/10.1016/0304-3940(95)11991-5.'
ieee: 'Y. Lü et al., “Expression of c-fos protein in substance P receptor-like
immunoreactive neurons in response to noxious stimuli on the urinary bladder:
an observation in the lumbosacral cord segments of the rat,” Neuroscience Letters,
vol. 198, no. 2. Elsevier, pp. 139–142, 1995.'
ista: 'Lü Y, Jin S, Xu T, Qin B, Li J, Ding Y, Shigemoto R, Mizuno N. 1995. Expression
of c-fos protein in substance P receptor-like immunoreactive neurons in response
to noxious stimuli on the urinary bladder: an observation in the lumbosacral cord
segments of the rat. Neuroscience Letters. 198(2), 139–142.'
mla: 'Lü, Yan, et al. “Expression of C-Fos Protein in Substance P Receptor-like
Immunoreactive Neurons in Response to Noxious Stimuli on the Urinary Bladder:
An Observation in the Lumbosacral Cord Segments of the Rat.” Neuroscience Letters,
vol. 198, no. 2, Elsevier, 1995, pp. 139–42, doi:10.1016/0304-3940(95)11991-5.'
short: Y. Lü, S. Jin, T. Xu, B. Qin, J. Li, Y. Ding, R. Shigemoto, N. Mizuno, Neuroscience
Letters 198 (1995) 139–142.
date_created: 2018-12-11T11:58:23Z
date_published: 1995-09-29T00:00:00Z
date_updated: 2022-06-28T12:54:14Z
day: '29'
doi: 10.1016/0304-3940(95)11991-5
extern: '1'
external_id:
pmid:
- '8592640'
intvolume: ' 198'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394095119915?via%3Dihub
month: '09'
oa_version: None
page: 139 - 142
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4338'
quality_controlled: '1'
status: public
title: 'Expression of c-fos protein in substance P receptor-like immunoreactive neurons
in response to noxious stimuli on the urinary bladder: an observation in the lumbosacral
cord segments of the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 198
year: '1995'
...
---
_id: '2561'
abstract:
- lang: eng
text: An antibody which recognizes specifically a metabotropic glutamate receptor,
mGluR7, was produced by using a trpE fusion protein containing a C-terminal sequence
of rat mGluR7. Neuropil in laminae I and II of the dorsal horn of the rat, as
well as many neuronal cell bodies in the dorsal root ganglion, showed mGluR7-like
immunoreactivity; the immunoreactivity in neuropil was seen in axon terminals,
which were filled with round synaptic vesicles and constituted axodendritic and
axosomatic asymmetric synapses. The mGluR7-like immunoreactivity in laminae I
and II in the dorsal horn was reduced after dorsal rhizotomy. The results indicate
that some axon terminals of the primary afferent fibers to laminae I and II of
the dorsal horn are provided with mGluR7.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Ohishi H, Nomura S, Ding Y, et al. Presynaptic localization of a metabotropic
glutamate receptor, mGluR7, in the primary afferent neurons: An immunohistochemical
study in the rat. Neuroscience Letters. 1995;202(1-2):85-88. doi:10.1016/0304-3940(95)12207-9'
apa: 'Ohishi, H., Nomura, S., Ding, Y., Shigemoto, R., Wada, E., Kinoshita, A.,
… Mizuno, N. (1995). Presynaptic localization of a metabotropic glutamate receptor,
mGluR7, in the primary afferent neurons: An immunohistochemical study in the rat.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12207-9'
chicago: 'Ohishi, Hitoshi, Sakashi Nomura, Yu Ding, Ryuichi Shigemoto, Eiki Wada,
Ayae Kinoshita, Jin Li, Akio Neki, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic
Localization of a Metabotropic Glutamate Receptor, MGluR7, in the Primary Afferent
Neurons: An Immunohistochemical Study in the Rat.” Neuroscience Letters.
Elsevier, 1995. https://doi.org/10.1016/0304-3940(95)12207-9.'
ieee: 'H. Ohishi et al., “Presynaptic localization of a metabotropic glutamate
receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study
in the rat,” Neuroscience Letters, vol. 202, no. 1–2. Elsevier, pp. 85–88,
1995.'
ista: 'Ohishi H, Nomura S, Ding Y, Shigemoto R, Wada E, Kinoshita A, Li J, Neki
A, Nakanishi S, Mizuno N. 1995. Presynaptic localization of a metabotropic glutamate
receptor, mGluR7, in the primary afferent neurons: An immunohistochemical study
in the rat. Neuroscience Letters. 202(1–2), 85–88.'
mla: 'Ohishi, Hitoshi, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR7, in the Primary Afferent Neurons: An Immunohistochemical Study
in the Rat.” Neuroscience Letters, vol. 202, no. 1–2, Elsevier, 1995, pp.
85–88, doi:10.1016/0304-3940(95)12207-9.'
short: H. Ohishi, S. Nomura, Y. Ding, R. Shigemoto, E. Wada, A. Kinoshita, J. Li,
A. Neki, S. Nakanishi, N. Mizuno, Neuroscience Letters 202 (1995) 85–88.
date_created: 2018-12-11T11:58:24Z
date_published: 1995-12-01T00:00:00Z
date_updated: 2022-06-28T12:44:57Z
day: '01'
doi: 10.1016/0304-3940(95)12207-9
extern: '1'
external_id:
pmid:
- '8787837'
intvolume: ' 202'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394095122079?via%3Dihub
month: '12'
oa_version: None
page: 85 - 88
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4337'
quality_controlled: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in
the primary afferent neurons: An immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 202
year: '1995'
...
---
_id: '2563'
abstract:
- lang: eng
text: By means of substance P receptor (SPR) immunofluorescence histochemistry combined
with Fluoro-Gold fluorescent retrograde labeling, SPR-like immunoreactive neurons
in the caudal subnucleus of the spinal trigeminal nucleus of the rat were observed
to send their axons to the nucleus of Kolliker-Fuse and ventrolateral part of
the lateral parabrachial nucleus bilaterally with a clear ipsilateral dominance.
These neurons were distributed mainly in lamina I, and additionally in lamina
III.
acknowledgement: 'The authors are grateful for photographic help of Ms. Miao-Li Zhang
and Mr. Akira Uesugi. This work was supported in part by Grants-in-Aid for Special
Research on Priority Areas 05267104, Scientific Research (B) 05454658, and Scientific
Research (C) 06680735 from the Ministry of Education, Science and Culture of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Takada M, Shigemoto R, Mizuno N. Trigeminoparabrachial projection neurons
showing substance P receptor-like immunoreactivity in the rat. Neuroscience
Research. 1995;23(4):415-418. doi:10.1016/0168-0102(95)00961-R
apa: Ding, Y., Takada, M., Shigemoto, R., & Mizuno, N. (1995). Trigeminoparabrachial
projection neurons showing substance P receptor-like immunoreactivity in the rat.
Neuroscience Research. Elsevier. https://doi.org/10.1016/0168-0102(95)00961-R
chicago: Ding, Yu, Masahiko Takada, Ryuichi Shigemoto, and Noboru Mizuno. “Trigeminoparabrachial
Projection Neurons Showing Substance P Receptor-like Immunoreactivity in the Rat.”
Neuroscience Research. Elsevier, 1995. https://doi.org/10.1016/0168-0102(95)00961-R.
ieee: Y. Ding, M. Takada, R. Shigemoto, and N. Mizuno, “Trigeminoparabrachial projection
neurons showing substance P receptor-like immunoreactivity in the rat,” Neuroscience
Research, vol. 23, no. 4. Elsevier, pp. 415–418, 1995.
ista: Ding Y, Takada M, Shigemoto R, Mizuno N. 1995. Trigeminoparabrachial projection
neurons showing substance P receptor-like immunoreactivity in the rat. Neuroscience
Research. 23(4), 415–418.
mla: Ding, Yu, et al. “Trigeminoparabrachial Projection Neurons Showing Substance
P Receptor-like Immunoreactivity in the Rat.” Neuroscience Research, vol.
23, no. 4, Elsevier, 1995, pp. 415–18, doi:10.1016/0168-0102(95)00961-R.
short: Y. Ding, M. Takada, R. Shigemoto, N. Mizuno, Neuroscience Research 23 (1995)
415–418.
date_created: 2018-12-11T11:58:24Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2022-06-28T09:50:42Z
day: '01'
doi: 10.1016/0168-0102(95)00961-R
extern: '1'
external_id:
pmid:
- '8602281'
intvolume: ' 23'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/016801029500961R?via%3Dihub
month: '11'
oa_version: None
page: 415 - 418
pmid: 1
publication: Neuroscience Research
publication_identifier:
issn:
- 0168-0102
publication_status: published
publisher: Elsevier
publist_id: '4336'
quality_controlled: '1'
status: public
title: Trigeminoparabrachial projection neurons showing substance P receptor-like
immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 23
year: '1995'
...
---
_id: '2712'
abstract:
- lang: eng
text: We study the generalizations of the well-known Lieb-Thirring inequality for
the magnetic Schrödinger operator with a nonconstant magnetic field. We use stochastic
methods to prove estimates on the moments of the negative eigenvalues.
acknowledgement: Work supported by the NSF grant PHY90-19433 A02, by the Alfred Sloan
Foundation dissertation Fellowship and by the Erwin Schrödinger Institute for Mathematical
Physics in Vienna.
alternative_title:
- 'Operator Theory: Advances and Applications'
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Magnetic Lieb-Thirring inequalities and stochastic oscillatory integrals.
In: Vol 78. Birkhäuser; 1995:127-132. doi:10.1007/978-3-0348-9092-2_13'
apa: 'Erdös, L. (1995). Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals (Vol. 78, pp. 127–132). Presented at the International Conference on
Partial Differential Operators and Mathematical Physics, Holzhau, Germany: Birkhäuser.
https://doi.org/10.1007/978-3-0348-9092-2_13'
chicago: Erdös, László. “Magnetic Lieb-Thirring Inequalities and Stochastic Oscillatory
Integrals,” 78:127–32. Birkhäuser, 1995. https://doi.org/10.1007/978-3-0348-9092-2_13.
ieee: L. Erdös, “Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals,” presented at the International Conference on Partial Differential
Operators and Mathematical Physics, Holzhau, Germany, 1995, vol. 78, pp. 127–132.
ista: 'Erdös L. 1995. Magnetic Lieb-Thirring inequalities and stochastic oscillatory
integrals. International Conference on Partial Differential Operators and Mathematical
Physics, Operator Theory: Advances and Applications, vol. 78, 127–132.'
mla: Erdös, László. Magnetic Lieb-Thirring Inequalities and Stochastic Oscillatory
Integrals. Vol. 78, Birkhäuser, 1995, pp. 127–32, doi:10.1007/978-3-0348-9092-2_13.
short: L. Erdös, in:, Birkhäuser, 1995, pp. 127–132.
conference:
end_date: 1995-07-09
location: Holzhau, Germany
name: International Conference on Partial Differential Operators and Mathematical
Physics
start_date: 1995-07-03
date_created: 2018-12-11T11:59:12Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T09:31:20Z
day: '01'
doi: 10.1007/978-3-0348-9092-2_13
extern: '1'
intvolume: ' 78'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-9092-2_13
month: '01'
oa_version: None
page: 127 - 132
publication_status: published
publisher: Birkhäuser
publist_id: '4184'
quality_controlled: '1'
status: public
title: Magnetic Lieb-Thirring inequalities and stochastic oscillatory integrals
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 78
year: '1995'
...
---
_id: '2724'
abstract:
- lang: eng
text: We study the generalizations of the well-known Lieb-Thirring inequality for
the magnetic Schrödinger operator with nonconstant magnetic field. Our main result
is the naturally expected magnetic Lieb-Thirring estimate on the moments of the
negative eigenvalues for a certain class of magnetic fields (including even some
unbounded ones). We develop a localization technique in path space of the stochastic
Feynman-Kac representation of the heat kernel which effectively estimates the
oscillatory effect due to the magnetic phase factor.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Magnetic Lieb-Thirring inequalities. Communications in Mathematical
Physics. 1995;170(3):629-668. doi:10.1007/BF02099152
apa: Erdös, L. (1995). Magnetic Lieb-Thirring inequalities. Communications in
Mathematical Physics. Springer. https://doi.org/10.1007/BF02099152
chicago: Erdös, László. “Magnetic Lieb-Thirring Inequalities.” Communications
in Mathematical Physics. Springer, 1995. https://doi.org/10.1007/BF02099152.
ieee: L. Erdös, “Magnetic Lieb-Thirring inequalities,” Communications in Mathematical
Physics, vol. 170, no. 3. Springer, pp. 629–668, 1995.
ista: Erdös L. 1995. Magnetic Lieb-Thirring inequalities. Communications in Mathematical
Physics. 170(3), 629–668.
mla: Erdös, László. “Magnetic Lieb-Thirring Inequalities.” Communications in
Mathematical Physics, vol. 170, no. 3, Springer, 1995, pp. 629–68, doi:10.1007/BF02099152.
short: L. Erdös, Communications in Mathematical Physics 170 (1995) 629–668.
date_created: 2018-12-11T11:59:16Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-28T09:19:36Z
day: '01'
doi: 10.1007/BF02099152
extern: '1'
intvolume: ' 170'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02099152
month: '06'
oa_version: None
page: 629 - 668
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4168'
quality_controlled: '1'
status: public
title: Magnetic Lieb-Thirring inequalities
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 170
year: '1995'
...
---
_id: '11677'
abstract:
- lang: eng
text: "We present an algorithm for maintaining the biconnected components of a graph
during a sequence of edge insertions and deletions. It requires linear storage
and preprocessing time. The amortized running time for insertions and for deletions
isO(m 2/3 ), wherem is the number of edges in the graph. Any query of the form
‘Are the verticesu andv biconnected?’ can be answered in timeO(1). This is the
first sublinear algorithm for this problem. We can also output all articulation
points separating any two vertices efficiently.\r\n\r\nIf the input is a plane
graph, the amortized running time for insertions and deletions drops toO(√n logn)
and the query time isO(log2 n), wheren is the number of vertices in the graph.
The best previously known solution takes timeO(n 2/3 ) per update or query."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. Fully dynamic biconnectivity in graphs. Algorithmica.
1995;13(6):503-538. doi:10.1007/bf01189067
apa: Henzinger, M. H. (1995). Fully dynamic biconnectivity in graphs. Algorithmica.
Springer Nature. https://doi.org/10.1007/bf01189067
chicago: Henzinger, Monika H. “Fully Dynamic Biconnectivity in Graphs.” Algorithmica.
Springer Nature, 1995. https://doi.org/10.1007/bf01189067.
ieee: M. H. Henzinger, “Fully dynamic biconnectivity in graphs,” Algorithmica,
vol. 13, no. 6. Springer Nature, pp. 503–538, 1995.
ista: Henzinger MH. 1995. Fully dynamic biconnectivity in graphs. Algorithmica.
13(6), 503–538.
mla: Henzinger, Monika H. “Fully Dynamic Biconnectivity in Graphs.” Algorithmica,
vol. 13, no. 6, Springer Nature, 1995, pp. 503–38, doi:10.1007/bf01189067.
short: M.H. Henzinger, Algorithmica 13 (1995) 503–538.
date_created: 2022-07-27T14:50:46Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-09-12T09:00:14Z
day: '01'
doi: 10.1007/bf01189067
extern: '1'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 503-538
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic biconnectivity in graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '1995'
...
---
_id: '11684'
abstract:
- lang: eng
text: 'This paper presents an algorithm for the fully dynamic biconnectivity problem
whose running time is exponentially faster than all previously known solutions.
It is the first dynamic algorithm that answers biconnectivity queries in time
O(log/sup 2/n) in a n-node graph and can be updated after an edge insertion or
deletion in polylogarithmic time. Our algorithm is a Las-Vegas style randomized
algorithm with the update time amortized update time O(log/sup 4/n). Only recently
the best deterministic result for this problem was improved to O(/spl radic/nlog/sup
2/n). We also give the first fully dynamic and a novel deletions-only transitive
closure (i.e. directed connectivity) algorithms. These are randomized Monte Carlo
algorithms. Let n be the number of nodes in the graph and let m/spl circ/ be the
average number of edges in the graph during the whole update sequence: The fully
dynamic algorithms achieve (1) query time O(n/logn) and update time O(m/spl circ//spl
radic/nlog/sup 2/n+n); or (2) query time O(n/logn) and update time O(nm/spl circ//sup
/spl mu/-1/)log/sup 2/n=O(nm/spl circ//sup 0.58/log/sup 2/n), where /spl mu/ is
the exponent for boolean matrix multiplication (currently /spl mu/=2.38). The
deletions-only algorithm answers queries in time O(n/logn). Its amortized update
time is O(nlog/sup 2/n).'
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: V.
full_name: King, V.
last_name: King
citation:
ama: 'Henzinger MH, King V. Fully dynamic biconnectivity and transitive closure.
In: Proceedings of IEEE 36th Annual Foundations of Computer Science. Institute
of Electrical and Electronics Engineers; 1995:664-672. doi:10.1109/SFCS.1995.492668'
apa: 'Henzinger, M. H., & King, V. (1995). Fully dynamic biconnectivity and
transitive closure. In Proceedings of IEEE 36th Annual Foundations of Computer
Science (pp. 664–672). Milwaukee, WI, United States: Institute of Electrical
and Electronics Engineers. https://doi.org/10.1109/SFCS.1995.492668'
chicago: Henzinger, Monika H, and V. King. “Fully Dynamic Biconnectivity and Transitive
Closure.” In Proceedings of IEEE 36th Annual Foundations of Computer Science,
664–72. Institute of Electrical and Electronics Engineers, 1995. https://doi.org/10.1109/SFCS.1995.492668.
ieee: M. H. Henzinger and V. King, “Fully dynamic biconnectivity and transitive
closure,” in Proceedings of IEEE 36th Annual Foundations of Computer Science,
Milwaukee, WI, United States, 1995, pp. 664–672.
ista: Henzinger MH, King V. 1995. Fully dynamic biconnectivity and transitive closure.
Proceedings of IEEE 36th Annual Foundations of Computer Science. Foundations of
Computer Science, 664–672.
mla: Henzinger, Monika H., and V. King. “Fully Dynamic Biconnectivity and Transitive
Closure.” Proceedings of IEEE 36th Annual Foundations of Computer Science,
Institute of Electrical and Electronics Engineers, 1995, pp. 664–72, doi:10.1109/SFCS.1995.492668.
short: M.H. Henzinger, V. King, in:, Proceedings of IEEE 36th Annual Foundations
of Computer Science, Institute of Electrical and Electronics Engineers, 1995,
pp. 664–672.
conference:
end_date: 1995-10-25
location: Milwaukee, WI, United States
name: Foundations of Computer Science
start_date: 1995-10-23
date_created: 2022-07-28T11:28:13Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2023-02-09T11:35:17Z
day: '01'
doi: 10.1109/SFCS.1995.492668
extern: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 664-672
publication: Proceedings of IEEE 36th Annual Foundations of Computer Science
publication_identifier:
isbn:
- 0-8186-7183-1
issn:
- 0272-5428
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic biconnectivity and transitive closure
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1995'
...
---
_id: '1943'
abstract:
- lang: eng
text: Transhydrogenase from beef-heart mitochondria was solubilised with Triton
X-100 and purified by column chromatography. The detergent-dispersed enzyme catalysed
the reduction of acetylpyridine adenine dinucleotide (AcPdAD+) by NADH, but only
in the presence of NADP+. Experiments showed that this reaction was cyclic; NADP(H),
whilst remaining bound to the enzyme, was alternately reduced by NADH and oxidised
by AcPdAD+. A period of incubation of the enzyme with NADPH at pH 6.0 led to inhibition
of the simple transhydrogenation reaction between AcPdAD+ and NADPH. However,
after such treatment, transhydrogenase acquired the ability to catalyse the (NADPH-dependent)
reduction of AcPdAD+ by NADH. It is suggested that this is a similar cycle to
the one described above. Evidently, the binding affinity for NADP+ increases as
a consequence of the inhibition process resulting from prolonged incubation with
NADPH. The pH dependences of simple and cyclic transhydrogenation reactions are
described. Though more complex than those in Escherichia coli transhydrogenase,
they are consistent with the view [Hutton, M., Day, J.M., Bizouarn, T. and Jackson,
J.B. (1994) Eur. J. Biochem. 219, 1041–10511] that, also in the mitochondrial
enzyme, binding the release of NADP+ and NADP are accompanied by binding and release
of a proton. The enzyme was successfully reconstituted into liposomes by a cholate
dilution procedure. The proteoliposomes catalysed cyclic NADPH-dependent reduction
of AcPdAD+ by NADH only when they were tightly coupled. However, they catalysed
cyclic NADP+-dependent reduction of AcPdAD+ by NADH only when they were uncoupled
eg. by addition of carbonylcyanide-p-trifluoromethoxyphenyl hydrazone. These observations
are evidence that the proton binding and release which accompany NADP+ binding
and release, respectively, take place on the inside of the vesicle, and that they
are components of the electrogenic processes of the enzyme.
acknowledgement: 'L.A.S. is grateful to the Wellcome Trust for a Research Fellowship.
Support from the Biotechnology and Biological Sciences Research Council is also
acknowledged. We thank our colleagues. Tania Bizouarn, Mike Hutton and Nick Cotton,
for advice and valuable discussion. '
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Baz
full_name: Jackson, Baz
last_name: Jackson
citation:
ama: Sazanov LA, Jackson B. Cyclic reactions catalysed by detergent-dispersed and
reconstituted transhydrogenase from beef heart mitochondria; implications for
the mechanism of proton translocation. Biochimica et Biophysica Acta - Bioenergetics.
1995;1231(3):304-312. doi:10.1016/0005-2728(95)00096-2
apa: Sazanov, L. A., & Jackson, B. (1995). Cyclic reactions catalysed by detergent-dispersed
and reconstituted transhydrogenase from beef heart mitochondria; implications
for the mechanism of proton translocation. Biochimica et Biophysica Acta -
Bioenergetics. Elsevier. https://doi.org/10.1016/0005-2728(95)00096-2
chicago: Sazanov, Leonid A, and Baz Jackson. “Cyclic Reactions Catalysed by Detergent-Dispersed
and Reconstituted Transhydrogenase from Beef Heart Mitochondria; Implications
for the Mechanism of Proton Translocation.” Biochimica et Biophysica Acta -
Bioenergetics. Elsevier, 1995. https://doi.org/10.1016/0005-2728(95)00096-2.
ieee: L. A. Sazanov and B. Jackson, “Cyclic reactions catalysed by detergent-dispersed
and reconstituted transhydrogenase from beef heart mitochondria; implications
for the mechanism of proton translocation,” Biochimica et Biophysica Acta -
Bioenergetics, vol. 1231, no. 3. Elsevier, pp. 304–312, 1995.
ista: Sazanov LA, Jackson B. 1995. Cyclic reactions catalysed by detergent-dispersed
and reconstituted transhydrogenase from beef heart mitochondria; implications
for the mechanism of proton translocation. Biochimica et Biophysica Acta - Bioenergetics.
1231(3), 304–312.
mla: Sazanov, Leonid A., and Baz Jackson. “Cyclic Reactions Catalysed by Detergent-Dispersed
and Reconstituted Transhydrogenase from Beef Heart Mitochondria; Implications
for the Mechanism of Proton Translocation.” Biochimica et Biophysica Acta -
Bioenergetics, vol. 1231, no. 3, Elsevier, 1995, pp. 304–12, doi:10.1016/0005-2728(95)00096-2.
short: L.A. Sazanov, B. Jackson, Biochimica et Biophysica Acta - Bioenergetics 1231
(1995) 304–312.
date_created: 2018-12-11T11:54:50Z
date_published: 1995-10-10T00:00:00Z
date_updated: 2022-06-29T15:04:47Z
day: '10'
doi: 10.1016/0005-2728(95)00096-2
extern: '1'
external_id:
pmid:
- '7578218'
intvolume: ' 1231'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/0005272895000962?via%3Dihub
month: '10'
oa: 1
oa_version: Published Version
page: 304 - 312
pmid: 1
publication: Biochimica et Biophysica Acta - Bioenergetics
publication_identifier:
issn:
- 0005-2728
publication_status: published
publisher: Elsevier
publist_id: '5142'
quality_controlled: '1'
status: public
title: Cyclic reactions catalysed by detergent-dispersed and reconstituted transhydrogenase
from beef heart mitochondria; implications for the mechanism of proton translocation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1231
year: '1995'
...
---
_id: '4587'
abstract:
- lang: eng
text: We argue that the standard constraints on liveness conditions in nonblocking
trace models—machine closure for closed systems, and receptiveness for open systems—are
unnecessarily weak and complex, and that liveness should, instead, be specified
by augmenting transition systems with acceptance conditions that satisfy a locality
constraint. First, locality implies machine closure and receptiveness, and thus
permits the composition and modular verification of live transition systems. Second,
while machine closure and receptiveness are based on infinite games, locality
is based on repeated finite games, and thus easier to check. Third, no expressive
power is lost by the restriction to local liveness conditions. We illustrate the
appeal of local liveness using the model of Fair Reactive Systems, a nonblocking
trace model of communicating processes.
acknowledgement: Supported in part by the NSF grant CCR-9200794, by the AFOSR contract
F49620-93-1-0056, and by the DARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Alur R, Henzinger TA. Local liveness for compositional modeling of fair reactive
systems. In: 7th International Conference on Computer Aided Verification.
Vol 939. Springer; 1995:166-179. doi:10.1007/3-540-60045-0_49'
apa: 'Alur, R., & Henzinger, T. A. (1995). Local liveness for compositional
modeling of fair reactive systems. In 7th International Conference on Computer
Aided Verification (Vol. 939, pp. 166–179). Liege, Belgium: Springer. https://doi.org/10.1007/3-540-60045-0_49'
chicago: Alur, Rajeev, and Thomas A Henzinger. “Local Liveness for Compositional
Modeling of Fair Reactive Systems.” In 7th International Conference on Computer
Aided Verification, 939:166–79. Springer, 1995. https://doi.org/10.1007/3-540-60045-0_49.
ieee: R. Alur and T. A. Henzinger, “Local liveness for compositional modeling of
fair reactive systems,” in 7th International Conference on Computer Aided Verification,
Liege, Belgium, 1995, vol. 939, pp. 166–179.
ista: 'Alur R, Henzinger TA. 1995. Local liveness for compositional modeling of
fair reactive systems. 7th International Conference on Computer Aided Verification.
CAV: Computer Aided Verification, LNCS, vol. 939, 166–179.'
mla: Alur, Rajeev, and Thomas A. Henzinger. “Local Liveness for Compositional Modeling
of Fair Reactive Systems.” 7th International Conference on Computer Aided Verification,
vol. 939, Springer, 1995, pp. 166–79, doi:10.1007/3-540-60045-0_49.
short: R. Alur, T.A. Henzinger, in:, 7th International Conference on Computer Aided
Verification, Springer, 1995, pp. 166–179.
conference:
end_date: 1995-07-05
location: Liege, Belgium
name: 'CAV: Computer Aided Verification'
start_date: 1995-07-03
date_created: 2018-12-11T12:09:37Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-09T14:05:04Z
day: '01'
doi: 10.1007/3-540-60045-0_49
extern: '1'
intvolume: ' 939'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-60045-0_49
month: '01'
oa_version: None
page: 166 - 179
publication: 7th International Conference on Computer Aided Verification
publication_identifier:
isbn:
- 978-3-540-60045-9
publication_status: published
publisher: Springer
publist_id: '120'
quality_controlled: '1'
status: public
title: Local liveness for compositional modeling of fair reactive systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 939
year: '1995'
...
---
_id: '4613'
abstract:
- lang: eng
text: We present a general framework for the formal specification and algorithmic
analysis of hybrid systems. A hybrid system consists of a discrete program with
an analog environment. We model hybrid systems as finite automata equipped with
variables that evolve continuously with time according to dynamical laws. For
verification purposes, we restrict ourselves to linear hybrid systems, where all
variables follow piecewise-linear trajectories. We provide decidability and undecidability
results for classes of linear hybrid systems, and we show that standard program-analysis
techniques can be adapted to linear hybrid systems. In particular, we consider
symbolic model-checking and minimization procedures that are based on the reachability
analysis of an infinite state space. The procedures iteratively compute state
sets that are definable as unions of convex polyhedra in multidimensional real
space. We also present approximation techniques for dealing with systems for which
the iterative procedures do not converge.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Costas
full_name: Courcoubetis, Costas
last_name: Courcoubetis
- first_name: Nicolas
full_name: Halbwachs, Nicolas
last_name: Halbwachs
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
- first_name: Xavier
full_name: Nicollin, Xavier
last_name: Nicollin
- first_name: Alfredo
full_name: Olivero, Alfredo
last_name: Olivero
- first_name: Joseph
full_name: Sifakis, Joseph
last_name: Sifakis
- first_name: Sergio
full_name: Yovine, Sergio
last_name: Yovine
citation:
ama: Alur R, Courcoubetis C, Halbwachs N, et al. The algorithmic analysis of hybrid
systems. Theoretical Computer Science. 1995;138(1):3-34. doi:10.1016/0304-3975(94)00202-T
apa: Alur, R., Courcoubetis, C., Halbwachs, N., Henzinger, T. A., Ho, P., Nicollin,
X., … Yovine, S. (1995). The algorithmic analysis of hybrid systems. Theoretical
Computer Science. Elsevier. https://doi.org/10.1016/0304-3975(94)00202-T
chicago: Alur, Rajeev, Costas Courcoubetis, Nicolas Halbwachs, Thomas A Henzinger,
Pei Ho, Xavier Nicollin, Alfredo Olivero, Joseph Sifakis, and Sergio Yovine. “The
Algorithmic Analysis of Hybrid Systems.” Theoretical Computer Science.
Elsevier, 1995. https://doi.org/10.1016/0304-3975(94)00202-T.
ieee: R. Alur et al., “The algorithmic analysis of hybrid systems,” Theoretical
Computer Science, vol. 138, no. 1. Elsevier, pp. 3–34, 1995.
ista: Alur R, Courcoubetis C, Halbwachs N, Henzinger TA, Ho P, Nicollin X, Olivero
A, Sifakis J, Yovine S. 1995. The algorithmic analysis of hybrid systems. Theoretical
Computer Science. 138(1), 3–34.
mla: Alur, Rajeev, et al. “The Algorithmic Analysis of Hybrid Systems.” Theoretical
Computer Science, vol. 138, no. 1, Elsevier, 1995, pp. 3–34, doi:10.1016/0304-3975(94)00202-T.
short: R. Alur, C. Courcoubetis, N. Halbwachs, T.A. Henzinger, P. Ho, X. Nicollin,
A. Olivero, J. Sifakis, S. Yovine, Theoretical Computer Science 138 (1995) 3–34.
date_created: 2018-12-11T12:09:45Z
date_published: 1995-02-06T00:00:00Z
date_updated: 2022-06-09T13:40:48Z
day: '06'
doi: 10.1016/0304-3975(94)00202-T
extern: '1'
intvolume: ' 138'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/030439759400202T?via%3Dihub
month: '02'
oa_version: None
page: 3 - 34
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
publist_id: '94'
quality_controlled: '1'
status: public
title: The algorithmic analysis of hybrid systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 138
year: '1995'
...
---
_id: '6162'
abstract:
- lang: eng
text: 'The tra-1 gene is the terminal global selector of somatic sex in Caenorhabditis
elegans: High tra-1 activity elicits female somatic development while low tra-1
activity elicits male development. Previous genetic studies defined a cascade
of negatively interacting genes that regulates tra-1 activity in response to the
primary sex-determining signal. Here, we investigate the last step in this regulatory
cascade, by studying rare gain-of-function (gf) mutations of tra-1 that direct
female somatic development irrespective of the upstream sex-determining signal.
These mutations appear to abolish negative regulation of tra-1 in male tissues.
We identify the lesions associated with 29 of these mutations and find that all
affect a short stretch of amino acid residues present in both protein products
of the tra-1 gene. Twenty-six alleles are associated with single nonconservative
amino acid substitutions. Two alleles affect tra-1 RNA splicing and generate messages
that omit part or all of the exon encoding this short stretch. These results suggest
that sexual regulation of tra-1 is achieved post-translationally, by an inhibitory
protein-protein interaction. The amino acid stretch altered by the tra-1(gf) mutations
may define a site of interaction for negative regulators of tra-1. The stretch
includes a potential phosphorylation site for glycogen synthase kinase 3 and may
be conserved in the human gene GLI3, a homolog of tra-1 identified previously.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: D.
full_name: Zarkower, D.
last_name: Zarkower
- first_name: J.
full_name: Hodgkin, J.
last_name: Hodgkin
citation:
ama: de Bono M, Zarkower D, Hodgkin J. Dominant feminizing mutations implicate protein-protein
interactions as the main mode of regulation of the nematode sex-determining gene
tra-1. Genes and Development. 1995;9(2):155-167. doi:10.1101/gad.9.2.155
apa: de Bono, M., Zarkower, D., & Hodgkin, J. (1995). Dominant feminizing mutations
implicate protein-protein interactions as the main mode of regulation of the nematode
sex-determining gene tra-1. Genes and Development. CSH Press. https://doi.org/10.1101/gad.9.2.155
chicago: Bono, Mario de, D. Zarkower, and J. Hodgkin. “Dominant Feminizing Mutations
Implicate Protein-Protein Interactions as the Main Mode of Regulation of the Nematode
Sex-Determining Gene Tra-1.” Genes and Development. CSH Press, 1995. https://doi.org/10.1101/gad.9.2.155.
ieee: M. de Bono, D. Zarkower, and J. Hodgkin, “Dominant feminizing mutations implicate
protein-protein interactions as the main mode of regulation of the nematode sex-determining
gene tra-1,” Genes and Development, vol. 9, no. 2. CSH Press, pp. 155–167,
1995.
ista: de Bono M, Zarkower D, Hodgkin J. 1995. Dominant feminizing mutations implicate
protein-protein interactions as the main mode of regulation of the nematode sex-determining
gene tra-1. Genes and Development. 9(2), 155–167.
mla: de Bono, Mario, et al. “Dominant Feminizing Mutations Implicate Protein-Protein
Interactions as the Main Mode of Regulation of the Nematode Sex-Determining Gene
Tra-1.” Genes and Development, vol. 9, no. 2, CSH Press, 1995, pp. 155–67,
doi:10.1101/gad.9.2.155.
short: M. de Bono, D. Zarkower, J. Hodgkin, Genes and Development 9 (1995) 155–167.
date_created: 2019-03-21T11:57:40Z
date_published: 1995-01-15T00:00:00Z
date_updated: 2021-01-12T08:06:29Z
day: '15'
doi: 10.1101/gad.9.2.155
extern: '1'
external_id:
pmid:
- '7851791'
intvolume: ' 9'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 155-167
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- '08909369'
publication_status: published
publisher: CSH Press
quality_controlled: '1'
status: public
title: Dominant feminizing mutations implicate protein-protein interactions as the
main mode of regulation of the nematode sex-determining gene tra-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '1995'
...
---
_id: '11805'
abstract:
- lang: eng
text: In this paper, we present sparse certificates for biconnectivity together
with algorithms for updating these certificates. We thus obtain fully-dynamic
algorithms for biconnectivity in graphs that run in O(√n log n log⌈m/n⌉) amortized
time per operation, where m is the number of edges and n is the number of nodes
in the graph. This improves upon the results in [11], in which algorithms were
presented running in O(√m) amortized time, and solves the open problem to find
certificates to speed up biconnectivity, as stated in [2].
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Han
full_name: Poutré, Han
last_name: Poutré
citation:
ama: 'Henzinger MH, Poutré H. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. In: 3rd Annual European Symposium on Algorithms.
Vol 979. Springer Nature; 1995:171–184. doi:10.1007/3-540-60313-1_142'
apa: 'Henzinger, M. H., & Poutré, H. (1995). Certificates and fast algorithms
for biconnectivity in fully-dynamic graphs. In 3rd Annual European Symposium
on Algorithms (Vol. 979, pp. 171–184). Corfu, Greece: Springer Nature. https://doi.org/10.1007/3-540-60313-1_142'
chicago: Henzinger, Monika H, and Han Poutré. “Certificates and Fast Algorithms
for Biconnectivity in Fully-Dynamic Graphs.” In 3rd Annual European Symposium
on Algorithms, 979:171–184. Springer Nature, 1995. https://doi.org/10.1007/3-540-60313-1_142.
ieee: M. H. Henzinger and H. Poutré, “Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs,” in 3rd Annual European Symposium on Algorithms,
Corfu, Greece, 1995, vol. 979, pp. 171–184.
ista: 'Henzinger MH, Poutré H. 1995. Certificates and fast algorithms for biconnectivity
in fully-dynamic graphs. 3rd Annual European Symposium on Algorithms. ESA: European
Symposium on Algorithms, LNCS, vol. 979, 171–184.'
mla: Henzinger, Monika H., and Han Poutré. “Certificates and Fast Algorithms for
Biconnectivity in Fully-Dynamic Graphs.” 3rd Annual European Symposium on Algorithms,
vol. 979, Springer Nature, 1995, pp. 171–184, doi:10.1007/3-540-60313-1_142.
short: M.H. Henzinger, H. Poutré, in:, 3rd Annual European Symposium on Algorithms,
Springer Nature, 1995, pp. 171–184.
conference:
end_date: 1995-09-27
location: Corfu, Greece
name: 'ESA: European Symposium on Algorithms'
start_date: 1995-09-25
date_created: 2022-08-11T14:09:52Z
date_published: 1995-09-01T00:00:00Z
date_updated: 2023-02-14T08:02:03Z
day: '01'
doi: 10.1007/3-540-60313-1_142
extern: '1'
intvolume: ' 979'
language:
- iso: eng
month: '09'
oa_version: None
page: 171–184
publication: 3rd Annual European Symposium on Algorithms
publication_identifier:
eisbn:
- '9783540449133'
eissn:
- 1611-3349
isbn:
- '9783540603139'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Certificates and fast algorithms for biconnectivity in fully-dynamic graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 979
year: '1995'
...
---
_id: '11806'
abstract:
- lang: eng
text: This paper presents insertions-only algorithms for maintaining the exact and
approximate size of the minimum edge cut and the minimum vertex cut of a graph.
The algorithms output the approximate or exact size k in time O(1) or O(log n)
and a cut of size k in time linear in its size. The amortized time per insertion
is O(1/ε 2) for a (2+ε)-approximation, O((log λ)((log n)/ε)2) for a (1+ε)-approximation,
and O(λ log n) for the exact size of the minimum edge cut, where n is the number
of nodes in the graph, λ is the size of the minimum cut and ε>0. The (2+ε)-approximation
algorithm and the exact algorithm are deterministic, the (1+ε)-approximation algorithm
is randomized. The algorithms are optimal in the sense that the time needed for
m insertions matches the time needed by the best static algorithm on a m-edge
graph. We also present a static 2-approximation algorithm for the size κ of the
minimum vertex cut in a graph, which takes time O(n 2 min(√n,κ)). This is a factor
of κ faster than the best algorithm for computing the exact size, which takes
time O(κ 2 n 2 +κ 3 n 1.5). We give an insertionsonly algorithm for maintaining
a (2+ε)-approximation of the minimum vertex cut with amortized insertion time
O(n(logκk)/ε).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Approximating minimum cuts under insertions. In: 22nd International
Colloquium on Automata, Languages and Programming. Vol 944. Springer Nature;
1995:280–291. doi:10.1007/3-540-60084-1_81'
apa: 'Henzinger, M. H. (1995). Approximating minimum cuts under insertions. In 22nd
International Colloquium on Automata, Languages and Programming (Vol. 944,
pp. 280–291). Szeged, Hungary: Springer Nature. https://doi.org/10.1007/3-540-60084-1_81'
chicago: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” In
22nd International Colloquium on Automata, Languages and Programming, 944:280–291.
Springer Nature, 1995. https://doi.org/10.1007/3-540-60084-1_81.
ieee: M. H. Henzinger, “Approximating minimum cuts under insertions,” in 22nd
International Colloquium on Automata, Languages and Programming, Szeged, Hungary,
1995, vol. 944, pp. 280–291.
ista: 'Henzinger MH. 1995. Approximating minimum cuts under insertions. 22nd International
Colloquium on Automata, Languages and Programming. ICALP: International Colloquium
on Automata, Languages, and Programming, LNCS, vol. 944, 280–291.'
mla: Henzinger, Monika H. “Approximating Minimum Cuts under Insertions.” 22nd
International Colloquium on Automata, Languages and Programming, vol. 944,
Springer Nature, 1995, pp. 280–291, doi:10.1007/3-540-60084-1_81.
short: M.H. Henzinger, in:, 22nd International Colloquium on Automata, Languages
and Programming, Springer Nature, 1995, pp. 280–291.
conference:
end_date: 1995-07-14
location: Szeged, Hungary
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 1995-07-10
date_created: 2022-08-11T14:17:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2023-02-14T08:09:08Z
day: '01'
doi: 10.1007/3-540-60084-1_81
extern: '1'
intvolume: ' 944'
language:
- iso: eng
month: '07'
oa_version: None
page: 280–291
publication: 22nd International Colloquium on Automata, Languages and Programming
publication_identifier:
eisbn:
- '9783540600848'
eissn:
- 1611-3349
isbn:
- '9783540494256'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Approximating minimum cuts under insertions
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 944
year: '1995'
...
---
_id: '11928'
abstract:
- lang: eng
text: "We present a model with restricted randomness for edge updates in dynamic
graph algorithms and a general technique\r\nfor analyzing the expected running
time of an update operation. This model is able to capture the average case in
many applications, since (1) it allows restrictions on the set of edges which
can be used for insertions and (2) the type (insertion or deletion) of each update
operation is arbitrary, i.e., not random. We use our technique to analyze existing
and new dynamic algorithms for maximum cardinality matching, minimum spanning
forest, connectivity, 2-edge connectivity,\r\nk-edge connectivity, k-vertex connectivity,
and bipartiteness. Given a random graph G with mo edges and n vertices and\r\na
sequence of 1 update operations such that the graph contains rni edges after operation
i, the expected time for performing the updates for any 1 is O(1 logn + n xi=,
l/fii) in the case of minimum spanning forests, connectivity, 2-\r\nedge connectivity,
and bipartiteness. The expected time per update operation is O(n) in the case
of maximum matching. For k-edge and k-vertex connectivity we also give improved
bounds. Additionally we give an insertions-only algorithm for maximum cardinality
matching with worst-case O(n) amortized time per insertion. "
article_processing_charge: No
author:
- first_name: David
full_name: Alberts, David
last_name: Alberts
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Alberts D, Henzinger MH. Average case analysis of dynamic graph algorithms.
In: 6th Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial
and Applied Mathematics; 1995:312-321.'
apa: 'Alberts, D., & Henzinger, M. H. (1995). Average case analysis of dynamic
graph algorithms. In 6th Annual ACM-SIAM Symposium on Discrete Algorithms
(pp. 312–321). San Francisco, CA, United States: Society for Industrial and Applied
Mathematics.'
chicago: Alberts, David, and Monika H Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” In 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
312–21. Society for Industrial and Applied Mathematics, 1995.
ieee: D. Alberts and M. H. Henzinger, “Average case analysis of dynamic graph algorithms,”
in 6th Annual ACM-SIAM Symposium on Discrete Algorithms, San Francisco,
CA, United States, 1995, pp. 312–321.
ista: 'Alberts D, Henzinger MH. 1995. Average case analysis of dynamic graph algorithms.
6th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete
Algorithms, 312–321.'
mla: Alberts, David, and Monika H. Henzinger. “Average Case Analysis of Dynamic
Graph Algorithms.” 6th Annual ACM-SIAM Symposium on Discrete Algorithms,
Society for Industrial and Applied Mathematics, 1995, pp. 312–21.
short: D. Alberts, M.H. Henzinger, in:, 6th Annual ACM-SIAM Symposium on Discrete
Algorithms, Society for Industrial and Applied Mathematics, 1995, pp. 312–321.
conference:
end_date: 1995-01-24
location: San Francisco, CA, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 1995-01-22
date_created: 2022-08-19T07:10:23Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2023-02-21T16:24:58Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://dl.acm.org/doi/10.5555/313651.313712
month: '01'
oa: 1
oa_version: Published Version
page: 312-321
publication: 6th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '0898713498'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
related_material:
record:
- id: '11680'
relation: later_version
status: public
scopus_import: '1'
status: public
title: Average case analysis of dynamic graph algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1995'
...
---
_id: '3454'
abstract:
- lang: eng
text: The study of gene expression and regulation in the central nervous system
(CNS) is a daunting task because of the diversity of neuronal phenotypes and the
complexity of many protein classes. Molecular cloning revealed the presence of
a large number of different protein families in the CNS, each comprising several
members. Ligand-gated ion channels may serve as an example to illustrate this
point (for review, see Unwin, 1993). Heterologous expression combined with electrophysiological
analysis suggests that ligand-gated channels are multimeric proteins with functional
properties depending on the subunit composition. Very little is known, however,
about how the functional properties of the recombinant and native receptors relate
to each other. Thus, it is of eminent importance to elucidate the subunit expression
profile in different types of neurons in the CNS and to correlate this with the
functional properties of the native receptors.
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Monyer H, Jonas PM. Polymerase chain reaction analysis of ion channel expression
in single neurons of brain slices. In: Sakmann B, Neher E, eds. Single-Channel
Recording. Plenum; 1995:357-373. doi:10.1007/978-1-4419-1229-9_16'
apa: Monyer, H., & Jonas, P. M. (1995). Polymerase chain reaction analysis of
ion channel expression in single neurons of brain slices. In B. Sakmann &
E. Neher (Eds.), Single-channel recording (pp. 357–373). Plenum. https://doi.org/10.1007/978-1-4419-1229-9_16
chicago: Monyer, Hannah, and Peter M Jonas. “Polymerase Chain Reaction Analysis
of Ion Channel Expression in Single Neurons of Brain Slices.” In Single-Channel
Recording, edited by Bert Sakmann and Erwin Neher, 357–73. Plenum, 1995. https://doi.org/10.1007/978-1-4419-1229-9_16.
ieee: H. Monyer and P. M. Jonas, “Polymerase chain reaction analysis of ion channel
expression in single neurons of brain slices,” in Single-channel recording,
B. Sakmann and E. Neher, Eds. Plenum, 1995, pp. 357–373.
ista: 'Monyer H, Jonas PM. 1995.Polymerase chain reaction analysis of ion channel
expression in single neurons of brain slices. In: Single-channel recording. ,
357–373.'
mla: Monyer, Hannah, and Peter M. Jonas. “Polymerase Chain Reaction Analysis of
Ion Channel Expression in Single Neurons of Brain Slices.” Single-Channel Recording,
edited by Bert Sakmann and Erwin Neher, Plenum, 1995, pp. 357–73, doi:10.1007/978-1-4419-1229-9_16.
short: H. Monyer, P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording,
Plenum, 1995, pp. 357–373.
date_created: 2018-12-11T12:03:25Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T09:13:01Z
day: '01'
doi: 10.1007/978-1-4419-1229-9_16
editor:
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Erwin
full_name: Neher, Erwin
last_name: Neher
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4419-1229-9_16
month: '01'
oa_version: None
page: 357 - 373
publication: Single-channel recording
publication_identifier:
isbn:
- 978-0-306-44870-6
publication_status: published
publisher: Plenum
publist_id: '2933'
quality_controlled: '1'
status: public
title: Polymerase chain reaction analysis of ion channel expression in single neurons
of brain slices
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3455'
abstract:
- lang: eng
text: At a synapse, the transmitter is stored in synaptic vesicles and is released
into the synaptic cleft almost instantaneously upon fusion of these vesicles with
the presynaptic membrane. Subsequently, the transmitter diffuses to ligand-gated
ion channels in the postsynaptic density, binds to them, and thereby causes channel
activation. Unfortunately, we have estimates neither of the exact amount of transmitter
in the synaptic vesicle nor of the concentration in the synaptic cleft reaching
the postsynaptic receptors, and in some cases even the identity of the transmitter
is unknown. These questions may be addressed by modeling of release and diffusion.
Such a theoretical approach, however, is based on several assumptions, some of
which lack experimental evidence.
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Jonas PM. Fast application of agonists to isolated membrane patches. In: Sakmann
B, Neher E, eds. Single-Channel Recording. Plenum; 1995:231-243. doi:10.1007/978-1-4419-1229-9_10'
apa: Jonas, P. M. (1995). Fast application of agonists to isolated membrane patches.
In B. Sakmann & E. Neher (Eds.), Single-channel recording (pp. 231–243).
Plenum. https://doi.org/10.1007/978-1-4419-1229-9_10
chicago: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
In Single-Channel Recording, edited by Bert Sakmann and Erwin Neher, 231–43.
Plenum, 1995. https://doi.org/10.1007/978-1-4419-1229-9_10.
ieee: P. M. Jonas, “Fast application of agonists to isolated membrane patches,”
in Single-channel recording, B. Sakmann and E. Neher, Eds. Plenum, 1995,
pp. 231–243.
ista: 'Jonas PM. 1995.Fast application of agonists to isolated membrane patches.
In: Single-channel recording. , 231–243.'
mla: Jonas, Peter M. “Fast Application of Agonists to Isolated Membrane Patches.”
Single-Channel Recording, edited by Bert Sakmann and Erwin Neher, Plenum,
1995, pp. 231–43, doi:10.1007/978-1-4419-1229-9_10.
short: P.M. Jonas, in:, B. Sakmann, E. Neher (Eds.), Single-Channel Recording, Plenum,
1995, pp. 231–243.
date_created: 2018-12-11T12:03:25Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-28T08:51:40Z
day: '01'
doi: 10.1007/978-1-4419-1229-9_10
editor:
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Erwin
full_name: Neher, Erwin
last_name: Neher
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4419-1229-9_10
month: '01'
oa_version: None
page: 231 - 243
publication: Single-channel recording
publication_identifier:
isbn:
- 978-0-306-44870-6
publication_status: published
publisher: Plenum
publist_id: '2932'
quality_controlled: '1'
status: public
title: Fast application of agonists to isolated membrane patches
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '3461'
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
citation:
ama: Jonas PM, Burnashev N. Molecular mechanisms controlling calcium entry through
AMPA-type glutamate receptor channels. Neuron. 1995;15(5):987-990. doi:10.1016/0896-6273(95)90087-X
apa: Jonas, P. M., & Burnashev, N. (1995). Molecular mechanisms controlling
calcium entry through AMPA-type glutamate receptor channels. Neuron. Elsevier.
https://doi.org/10.1016/0896-6273(95)90087-X
chicago: Jonas, Peter M, and Nail Burnashev. “Molecular Mechanisms Controlling Calcium
Entry through AMPA-Type Glutamate Receptor Channels.” Neuron. Elsevier,
1995. https://doi.org/10.1016/0896-6273(95)90087-X.
ieee: P. M. Jonas and N. Burnashev, “Molecular mechanisms controlling calcium entry
through AMPA-type glutamate receptor channels,” Neuron, vol. 15, no. 5.
Elsevier, pp. 987–990, 1995.
ista: Jonas PM, Burnashev N. 1995. Molecular mechanisms controlling calcium entry
through AMPA-type glutamate receptor channels. Neuron. 15(5), 987–990.
mla: Jonas, Peter M., and Nail Burnashev. “Molecular Mechanisms Controlling Calcium
Entry through AMPA-Type Glutamate Receptor Channels.” Neuron, vol. 15,
no. 5, Elsevier, 1995, pp. 987–90, doi:10.1016/0896-6273(95)90087-X.
short: P.M. Jonas, N. Burnashev, Neuron 15 (1995) 987–990.
date_created: 2018-12-11T12:03:27Z
date_published: 1995-11-01T00:00:00Z
date_updated: 2022-06-28T08:34:36Z
day: '01'
doi: 10.1016/0896-6273(95)90087-X
extern: '1'
external_id:
pmid:
- '7576666'
intvolume: ' 15'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/089662739590087X?via%3Dihub
month: '11'
oa: 1
oa_version: Published Version
page: 987 - 990
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular mechanisms controlling calcium entry through AMPA-type glutamate
receptor channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1995'
...
---
_id: '3478'
abstract:
- lang: eng
text: 1. Properties of dendritic glutamate receptor (GluR) channels were investigated
using fast application of glutamate to outside-out membrane patches isolated from
the apical dendrites of CA3 and CA1 pyramidal neurons in rat hippocampal slices.
CA3 patches were formed (15-76 μm from the soma) in the region of messy fibre
(MF) synapses, and CA1 patches (25-174 μm from the soma) in the region of Schaffer
collateral (SC) innervation. 2. Dual-component responses consisting of a rapidly
rising and decaying component followed by a second, substantially slower, component
were elicited by 1 ms pulses of 1 mM glutamate in the presence of 10 μM glycine
and absence of external Mg2+. The fast component was selectively blocked by 2-5
μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the slow component by 30 μM
D-2-amino-5-phosphonopentanoic acid (D-AP5), suggesting that the fast and slow
components were mediated by the GluR channels of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate
(AMPA) and NMDA type, respectively. The peak amplitude ratio of the NMDA to AMPA
receptor-mediated components varied between 0.03 and 0.62 in patches from both
CA3 and CA1 dendrites. Patches lacking either component were rarely observed.
3. The peak current-voltage (I-V) relationship of the fast component was almost
linear, whereas the I-V relationship of the slow component showed a region of
negative slope in the presence of 1 mM external Mg2+. The reversal potential for
both components was close to 0 mV. 4. Kainate-preferring GluR channels did not
contribute appreciably to the response to glutamate. The responses to 100 ms pulses
of 1 mM glutamate were mimicked by application of 1 mM AMPA, whereas 1 mM kainate
produced much smaller, weakly desensitizing currents. This suggests that the fast
component is primarily mediated by the action of glutamate on AMPA-preferring
receptors. 5. The mean elementary conductance of AMPA receptor channels was about
10 pS, as estimated by non-stationary fluctuation analysis. The permeability of
these channels to Ca2+ was low (~5% of the permeability to Cs+). 6. The elementary
conductance of NMDA receptor channels was larger, with a main conductance state
of about 45 pS. These channels were 3.6 times more permeable to Ca2+ than to Cs+.
7. AMPA receptor-mediated currents activated rapidly in response to 1 ms pulses
of 1 mM glutamate and deactivated with a predominant, fast time constant and a
smaller, slower component (τ1≃2 ms, τ2≃8 ms, contributing ~80 and ~20% to the
total decay amplitude, respectively). Desensitization of the current during a
100 ms pulse was best fitted by two time constants (τ1≃10 ms, ~60%; τ2≃34 ms,
~40%). 8. NMDA receptor-mediated currents in response to 1 ms pulses of 1 mM glutamate
activated and deactivated much more slowly than AMPA receptor-mediated currents.
The time course could be described by a single exponential rising phase (τ≃7 ms)
followed by a double exponential decay (τ1≃200 ms, ~80%; τ2≃1-3 s, ~20%). 9. Mg2+
blocked the NMDA component in a voltage-dependent manner, with a half-maximal
inhibitory concentration (IC50) of 21 μM at -80 mV. At physiological Mg2+ concentrations,
block of the NMDA component could be rapidly relieved with voltage jumps from
negative to positive potentials. Block of the current upon return to negative
potentials occurred almost instantaneously. 10. Zn2+ also selectively-blocked
the NMDA receptor-mediated current with an IC50 of 22 μM, but this block differed
from that of Mg2+ in that it showed little voltage dependence. Rapid application
of Zn2+ together with glutamate produced partial block of the current. More block
was observed if Zn2+ and glutamate were co-applied when NMDA receptor channels
were already open. 11. The functional properties of dendritic GluRs were similar
to those found at the soma. Knowledge of these properties facilitated simulations
investigating the contribution of coactivated AMPA and NMDA receptors to synaptic
depolarization and Ca2+ entry into dendritic spines. Because of its slow deactivation,
the NMDA receptor-mediated current contributes substantially to depolarization
and Ca2+ entry and is susceptible to modulation over a period of seconds, either
by backpropagating action potentials or by the release of Zn2+ from presynaptic
boutons.
acknowledgement: We thank M.Hausser, A.Roth, P.Ruppersberg, and G.Stuart for helpful
discussions and M.H. and G.S. for critically reading the manuscript. We also thank
M.Kaiser for expert technical assistance and F.Helmchen, M.Huke and A.Roth for computer
programming. Financial support from the Alexander von Humboldt Foundation and the
Deutsche Forschungsgemeinschaft (SFB317) is gratefully acknowledged.
article_processing_charge: No
article_type: original
author:
- first_name: Nelson
full_name: Spruston, Nelson
last_name: Spruston
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Spruston N, Jonas PM, Sakmann B. Dendritic glutamate receptor channels in rat
hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology. 1995;482(Pt
2):325-352. doi:10.1113/jphysiol.1995.sp020521
apa: Spruston, N., Jonas, P. M., & Sakmann, B. (1995). Dendritic glutamate receptor
channels in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020521
chicago: Spruston, Nelson, Peter M Jonas, and Bert Sakmann. “Dendritic Glutamate
Receptor Channels in Rat Hippocampal CA3 and CA1 Pyramidal Neurons.” Journal
of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020521.
ieee: N. Spruston, P. M. Jonas, and B. Sakmann, “Dendritic glutamate receptor channels
in rat hippocampal CA3 and CA1 pyramidal neurons,” Journal of Physiology,
vol. 482, no. Pt 2. Wiley-Blackwell, pp. 325–352, 1995.
ista: Spruston N, Jonas PM, Sakmann B. 1995. Dendritic glutamate receptor channels
in rat hippocampal CA3 and CA1 pyramidal neurons. Journal of Physiology. 482(Pt
2), 325–352.
mla: Spruston, Nelson, et al. “Dendritic Glutamate Receptor Channels in Rat Hippocampal
CA3 and CA1 Pyramidal Neurons.” Journal of Physiology, vol. 482, no. Pt
2, Wiley-Blackwell, 1995, pp. 325–52, doi:10.1113/jphysiol.1995.sp020521.
short: N. Spruston, P.M. Jonas, B. Sakmann, Journal of Physiology 482 (1995) 325–352.
date_created: 2018-12-11T12:03:32Z
date_published: 1995-01-15T00:00:00Z
date_updated: 2022-06-28T08:08:40Z
day: '15'
doi: 10.1113/jphysiol.1995.sp020521
extern: '1'
external_id:
pmid:
- '7536248'
intvolume: ' 482'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1995.sp020521
month: '01'
oa: 1
oa_version: Published Version
page: 325 - 352
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2909'
quality_controlled: '1'
status: public
title: Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal
neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 482
year: '1995'
...
---
_id: '3479'
abstract:
- lang: eng
text: 1. Glutamate receptor (GluR) channels were studied in basket cells in the
dentate gyrus of rat hippocampal slices. Basket cells were identified by their
location, dendritic morphology and high frequency of action potentials generated
during sustained current injection. 2. Dual-component currents were activated
by fast application of glutamate to outside-out membrane patches isolated from
basket cell somata (10 μM glycine, no external Mg2+). The fast component was selectively
blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), the slow component by
D-2-amino-5-phosphonopentanoic acid (D-AP5). This suggests that the two components
were mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR)/kainate
receptor and N-methyl-D-aspartate receptor (NMDAR) channels, respectively. The
mean ratio of the peak current of the NMDAR component to that of the AMPAR/kainate
receptor component was 0.22 (1 ms pulses of 10 mM glutamate). 3. The AMPAR/kainate
receptor component, which was studied in isolation in the presence of D-AP5, was
identified as AMPAR mediated on the basis of the preferential activation by AMPA
as compared with kainate, the weak desensitization of kainate-activated currents,
the cross-desensitization between AMPA and kainate, and the reduction of desensitization
by cyclothiazide. 4. Deactivation of basket cell AMPARs following 1 ms pulses
of glutamate occurred with a time constant (τ) of 1.2 ± 0.1 ms (mean ± S.E.M.).
During 100 ms glutamate pulses, AMPARs desensitized with a τ of 3.7 ± 0.2 ms.
5. The peak current-voltage (I-V) relation of AMPAR-mediated currents in Na+-rich
extracellular solution showed a reversal potential of -4.0 ± 2.6 mV and was characterized
by a doubly rectifying shape. The conductance of single AMPAR channels was estimated
as 22.6 ± 1.6 pS using non-stationary fluctuation analysis. AMPARs expressed in
hippocampal basket cells mere highly Ca2+ permeable (P(Ca)/P(K) = 1.79). 6. NMDARs
in hippocampal basket cells were studied in isolation in the presence of CNQX.
Deactivation of NMDARs activated by glutamate pulses occurred bi-exponentially
with mean τ values of 266 ± 23 ms (76%) and 2620 ± 383 ms (24%). 7. The peak I-V
relation of the NMDAR-mediated component in Na+-rich extracellular solution showed
a reversal potential of 1.5 ± 0.6 mV and a region of negative slope at negative
membrane potentials in the presence of external Mg2+, due to voltage-dependent
block by these ions. The conductance of single NMDAR channels in the main open
state was 50.2 ± 1.8 pS. NMDARs in hippocampal basket cells were highly permeable
to Ca2+ (P(Ca)/P(K) = 6.68). 8. AMPARs in hippocampal basket cells are characterized
by about threefold faster kinetics and twentyfold higher Ca2+ permeability than
AMPARs in hippocampal granule or pyramidal cells. Simulations show that the Ca2+
influx through basket cell AMPARs is comparable to that through NMDARs at negative
membrane potentials with physiological concentrations of Ca2+ and Mg2+. This suggests
a dual pathway of synaptically mediated Ca2+ entry into interneurones.
acknowledgement: We thank Drs M.Häusser and H.Markram for critically reading the manuscript
and M.Kaiser for technical assistance. Supported by the Deutsche Forschungsgemeinschaft
(SFB-317/B14 grant to P.J. and a Graduiertenkollegstipendium to J.R.P.G.)
article_processing_charge: No
article_type: original
author:
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Koh D, Geiger J, Jonas PM, Sakmann B. Ca(2+)-permeable AMPA and NMDA receptor
channels in basket cells of rat hippocampal dentate gyrus. Journal of Physiology.
1995;485(Pt 2):383-402. doi:10.1113/jphysiol.1995.sp020737
apa: Koh, D., Geiger, J., Jonas, P. M., & Sakmann, B. (1995). Ca(2+)-permeable
AMPA and NMDA receptor channels in basket cells of rat hippocampal dentate gyrus.
Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1995.sp020737
chicago: Koh, Duk, Jörg Geiger, Peter M Jonas, and Bert Sakmann. “Ca(2+)-Permeable
AMPA and NMDA Receptor Channels in Basket Cells of Rat Hippocampal Dentate Gyrus.”
Journal of Physiology. Wiley-Blackwell, 1995. https://doi.org/10.1113/jphysiol.1995.sp020737.
ieee: D. Koh, J. Geiger, P. M. Jonas, and B. Sakmann, “Ca(2+)-permeable AMPA and
NMDA receptor channels in basket cells of rat hippocampal dentate gyrus,” Journal
of Physiology, vol. 485, no. Pt 2. Wiley-Blackwell, pp. 383–402, 1995.
ista: Koh D, Geiger J, Jonas PM, Sakmann B. 1995. Ca(2+)-permeable AMPA and NMDA
receptor channels in basket cells of rat hippocampal dentate gyrus. Journal of
Physiology. 485(Pt 2), 383–402.
mla: Koh, Duk, et al. “Ca(2+)-Permeable AMPA and NMDA Receptor Channels in Basket
Cells of Rat Hippocampal Dentate Gyrus.” Journal of Physiology, vol. 485,
no. Pt 2, Wiley-Blackwell, 1995, pp. 383–402, doi:10.1113/jphysiol.1995.sp020737.
short: D. Koh, J. Geiger, P.M. Jonas, B. Sakmann, Journal of Physiology 485 (1995)
383–402.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-06-01T00:00:00Z
date_updated: 2022-06-28T07:54:44Z
day: '01'
doi: 10.1113/jphysiol.1995.sp020737
extern: '1'
external_id:
pmid:
- '7545230'
intvolume: ' 485'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1158000/pdf/jphysiol00319-0104.pdf
month: '06'
oa: 1
oa_version: Published Version
page: 383 - 402
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2908'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ca(2+)-permeable AMPA and NMDA receptor channels in basket cells of rat hippocampal
dentate gyrus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 485
year: '1995'
...
---
_id: '3480'
abstract:
- lang: eng
text: Recording of glutamate-activated currents in membrane patches was combine
with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified
cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons
of hippocampus and neocortex and in auditory relay neurons and Bergmann glial
cells indicates that the GluR-B subunit in its flip version determines formation
of receptors with relatively slow gating, whereas the GluR-D subunit promotes
assembly of more rapidly gated receptors. The relation between Ca 2+ permeability
of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the
dominance of this subunit in determining the Ca 2+ permeability of native receptors.
The results suggest that differential expression of GluR-B and GluR-D subunit
genes, as well as splicing end editing of their mRNAs, account for the differences
in gating and Ca 2+ permeability of native AMPAR channels.
acknowledgement: "We thank Ulla Amtmann for efficient help with the molecular analysis.
We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice
concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for
critically reading the manuscript. Funded in part by Bundesministerium für Forschung
und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant
SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program
of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs
of publication of this article were defrayed in part by the payment of page charges.
This article must therefore be hereby\r\nmarked “advertisement” in accordance with
18 USC Section 1734 solely to Indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Thorsten
full_name: Melcher, Thorsten
last_name: Melcher
- first_name: Duk
full_name: Koh, Duk
last_name: Koh
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
citation:
ama: Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines
gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4
apa: Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., &
Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+)
permeability of AMPA receptors in principal neurons and interneurons in rat CNS.
Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4
chicago: Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter
M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4.
ieee: J. Geiger et al., “Relative abundance of subunit mRNAs determines gating
and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons
in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995.
ista: Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995.
Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1),
193–204.
mla: Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating
and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons
in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4.
short: J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer,
Neuron 15 (1995) 193–204.
date_created: 2018-12-11T12:03:33Z
date_published: 1995-07-01T00:00:00Z
date_updated: 2022-06-28T07:47:09Z
day: '01'
doi: 10.1016/0896-6273(95)90076-4
extern: '1'
external_id:
pmid:
- '7619522'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub
month: '07'
oa: 1
oa_version: Published Version
page: 193 - 204
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability
of AMPA receptors in principal neurons and interneurons in rat CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1995'
...