---
_id: '4214'
abstract:
- lang: eng
text: 'Zebrafish embryos and larvae have stage-specific patterns of motility or
locomotion, Two embryonic structures accomplish this behavior: the central nervous
system (CNS) and skeletal muscles. To identify genes that are functionally involved
in mediating and controlling different patterns of embryonic and larval motility,
we included a simple touch response test in our zebrafish large-scale genetic
screen, In total we identified 166 mutants with specific defects in embryonic
motility. These mutants fall into 14 phenotypically distinct groups comprising
at least 48 genes, Here we describe the various phenotypic groups including mutants
with no or reduced motility, mechanosensory defective mutants, ''spastic'' mutants,
circling mutants and motor circuit defective mutants, In 63 mutants, defining
18 genes, striation of semitic muscles is reduced, Phenotypic analysis provides
evidence that these 18 genes have distinct and consecutive functions during semitic
muscle development. The genes sloth (slo) and frozen (fro) already act during
myoblast differentiation, while 13 genes appear to function later, in the formation
of myofibers and the organization of sarcomeres, Mutations in four other genes
result in muscle-specific degeneration, 103 mutations, defining at least 30 genes,
cause no obvious defects in muscle formation and may instead affect neuronal development.
Analysis of the behavioral defects suggests that these genes participate in the
diverse locomotion patterns observed, such as touch response, rhythmic tail movements,
equilibrium control, or that they simply confer general motility to the animal,
In some of these mutants specific defects in the developing nervous system are
detected, Mutations in two genes, nevermind (nev) and macho (mao), affect axonal
projection in the optic tectum, whereas axon formation and elongation of motorneurons
are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes.'
acknowledgement: We would like to thank C. Kimmel, J. Eisen and M. Westerfield for
providing the nic and fub mutant strains used for complementation and for the znp1
antibody. In addition we thank Tanja Whitfield and Suresh Jesuthesan for critical
reading of the manuscript. This work was supported by a DFG postdoctoral fellowship
Gr 1370/1-1 to M.G.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Granato M, Van Eeden F, Schach U, et al. Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. 1996;123:399-413.
doi:10.1242/dev.123.1.399
apa: Granato, M., Van Eeden, F., Schach, U., Trowe, T., Brand, M., Furutani Seiki,
M., … Nüsslein Volhard, C. (1996). Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.399
chicago: Granato, Michael, Fredericus Van Eeden, Ursula Schach, Torsten Trowe, Michael
Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Genes Controlling and Mediating
Locomotion Behavior of the Zebrafish Embryo and Larva.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.399.
ieee: M. Granato et al., “Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva,” Development, vol. 123. Company of Biologists,
pp. 399–413, 1996.
ista: Granato M, Van Eeden F, Schach U, Trowe T, Brand M, Furutani Seiki M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva. Development. 123, 399–413.
mla: Granato, Michael, et al. “Genes Controlling and Mediating Locomotion Behavior
of the Zebrafish Embryo and Larva.” Development, vol. 123, Company of Biologists,
1996, pp. 399–413, doi:10.1242/dev.123.1.399.
short: M. Granato, F. Van Eeden, U. Schach, T. Trowe, M. Brand, M. Furutani Seiki,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 399–413.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:20:50Z
day: '01'
doi: 10.1242/dev.123.1.399
extern: '1'
external_id:
pmid:
- '9007258'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 399 - 413
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes controlling and mediating locomotion behavior of the zebrafish embryo
and larva
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4215'
abstract:
- lang: eng
text: In a screen for early developmental mutants of the zebrafish, we have identified
mutations specifically affecting the internal organs, We identified 53 mutations
affecting the cardiovascular system, Nine of them affect specific landmarks of
heart morphogenesis. Mutations in four genes cause a failure in the fusion of
the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no
heart venticle is visible and the atrium is directly fused to the outflow tract.
In the overlooped mutant, the relative position of the two heart chambers is distorted,
The heart is enormously enlarged in the santa mutant, In two mutants, scotch tape
and superglue, the cardiac jelly between the two layers of the heart is significantly
reduced, We also identified a number of mutations affecting the function of the
heart, The mutations affecting heart function can be subdivided into two groups,
one affecting heart contraction and another affecting the rhythm of the heart
beat. Among the contractility group of mutants are 5 with no heart beat at all
and 15 with a reduced heart beat of one or both chambers, 6 mutations are in the
rhythmicity group and specifically affect the beating pattern of the heart, Mutations
in two genes, bypass and kurzschluss, cause specific defects in the circulatory
system, In addition to the heart mutants, we identified 23 mutations affecting
the integrity of the liver, the intestine or the kidney, In this report, we demonstrate
that it is feasible to screen for genes specific for the patterning or function
of certain internal organs in the zebrafish, The mutations presented here could
serve as an entrypoint to the establishment of a genetic hierarchy underlying
organogenesis.
acknowledgement: We thank Chris Simpson and Colleen Boggs for excellent technical
help. We thank Mark C. Fishman for the advice and providing fish for complementation;
Bernadette Fouquet, Kerri S. Warren and Brant M. Weinstein for critically reading
the manuscript. JNC is supported in part by NIH grant RO1-HL49579 to Mark C. Fishman.
article_processing_charge: No
article_type: original
author:
- first_name: Jaunian
full_name: Chen, Jaunian
last_name: Chen
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Chen J, Haffter P, Odenthal J, et al. Mutations affecting the cardiovascular
system and other internal organs in zebrafish. Development. 1996;123:293-302.
doi:10.1242/dev.123.1.293
apa: Chen, J., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Van Eeden, F.,
… Nüsslein Volhard, C. (1996). Mutations affecting the cardiovascular system and
other internal organs in zebrafish. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.293
chicago: Chen, Jaunian, Pascal Haffter, Jörg Odenthal, Elisabeth Vogelsang, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting
the Cardiovascular System and Other Internal Organs in Zebrafish.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.293.
ieee: J. Chen et al., “Mutations affecting the cardiovascular system and
other internal organs in zebrafish,” Development, vol. 123. Company of
Biologists, pp. 293–302, 1996.
ista: Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R,
Mullins M, Nüsslein Volhard C. 1996. Mutations affecting the cardiovascular system
and other internal organs in zebrafish. Development. 123, 293–302.
mla: Chen, Jaunian, et al. “Mutations Affecting the Cardiovascular System and Other
Internal Organs in Zebrafish.” Development, vol. 123, Company of Biologists,
1996, pp. 293–302, doi:10.1242/dev.123.1.293.
short: J. Chen, P. Haffter, J. Odenthal, E. Vogelsang, M. Brand, F. Van Eeden, M.
Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D.
Kane, R. Kelsh, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 293–302.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T13:11:56Z
day: '01'
doi: 10.1242/dev.123.1.293
extern: '1'
external_id:
pmid:
- '9007249'
intvolume: ' 123'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/293/39344/Mutations-affecting-the-cardiovascular-system-and
month: '12'
oa: 1
oa_version: Published Version
page: 293 - 302
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1902'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting the cardiovascular system and other internal organs in
zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4216'
abstract:
- lang: eng
text: Tissues of the dorsal midline of vertebrate embryos, such as notochord and
floor plate, have been implicated in inductive interactions that pattern the neural
tube and somites. In our screen for embryonic visible mutations in the zebrafish
we found 113 mutations in more than 27 genes with altered body shape, often with
additional defects in CNS development. We concentrated on a subgroup of mutations
in ten genes (the midline-group) that cause defective development of the floor
plate. By using floor plate markers, such as the signaling molecule sonic hedgehog,
we show that the schmalspur (sur) gene is needed for early floor plate development,
similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene.
In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted
to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In
the underlying mesendodermal tissue of the head, sur is needed only for development
of the posterior prechordal plate, whereas oep and eye are required for both anterior
and posterior prechordal plate development. Our analysis of sur mutants suggests
that defects within the posterior prechordal plate may cause aberrant development
of ventral CNS structures in the mid- and hindbrain. Later development of the
floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour,
schmalkars and monorail embryos; these mutants often show additional defects in
tissues that are known to depend on signals from notochord and floor plate, For
example, sur, con, and yot mutants show reduction of motor neurons; median deletions
of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and
dtr mutants often show no or abnormal formation of the optic chiasm. We also find
fusions of the ventral neurocranium for all midline mutants tested, which may
reveal a hitherto unrecognized function of the midline in influencing differentiation
of neural crest cells at their destination. As a working hypothesis, we propose
that midline-group genes may act to maintain proper structure and inductive function
of zebrafish midline tissues.
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss
and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg
and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript,
his colleagues at the institute for numerous discussions, Inge Zimmermann for patient
sectioning, and Silke Hein for help during the final\r\nstages of this work. M.
B. was supported by a Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Rolf
full_name: Karlstrom, Rolf
last_name: Karlstrom
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Alexander
full_name: Picker, Alexander
last_name: Picker
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of
the midline and general body shape during zebrafish embryogenesis. Development.
1996;123(1):129-142. doi:10.1242/dev.123.1.129
apa: Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle,
D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline
and general body shape during zebrafish embryogenesis. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.129
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri,
Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development
of the Midline and General Body Shape during Zebrafish Embryogenesis.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.129
.
ieee: M. Brand et al., “Mutations affecting development of the midline and
general body shape during zebrafish embryogenesis,” Development, vol. 123,
no. 1. Company of Biologists, pp. 129–142, 1996.
ista: Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker
A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations
affecting development of the midline and general body shape during zebrafish embryogenesis.
Development. 123(1), 129–142.
mla: Brand, Michael, et al. “Mutations Affecting Development of the Midline and
General Body Shape during Zebrafish Embryogenesis.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 129–42, doi:10.1242/dev.123.1.129 .
short: M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle,
A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter,
M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard,
Development 123 (1996) 129–142.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T12:55:13Z
day: '01'
doi: '10.1242/dev.123.1.129 '
extern: '1'
external_id:
pmid:
- '9007235 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and
month: '12'
oa: 1
oa_version: Published Version
page: 129 - 142
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1900'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the midline and general body shape during
zebrafish embryogenesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4219'
abstract:
- lang: eng
text: 'Mutations in two genes affect the formation of the boundary between midbrain
and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos
lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric
duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that
the MHB region and the dorsal and ventral midbrain are absent or abnormal, but
that the rostral hindbrain is unaffected with the exception of the cerebellum,
Using markers that are expressed during its formation (eng, wnt1 and pax-b), we
find that the MHB region is already misspecified in noi mutant embryos during
late gastrulation. The tectum is initially present and later degenerates, The
defect in ace mutant embryos is more restricted: MHB and cerebellum are absent,
but a tectum is formed, Molecular organisation of the tectum and tegmentum is
disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained,
We propose that noi and ace are required for development of the MHB region and
of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB
region, Presence of pax-b RNA, and absence of pax-b protein, together with the
observation of genetic linkage and the occurrence of a point mutation, show that
noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue
of the Drosophila gene paired, which is involved in a pathway of cellular interactions
at the posterior compartment boundary in Drosophila, Our results confirm and extend
a previous report, and show that at least one member of this conserved signalling
pathway is required for formation of the boundary between midbrain and hindbrain
in the zebrafish.'
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir
Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder,
Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B
would like to thank his colleagues for numerous discussions, and Francisco Pelegri,
Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also
to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression,
and especially to Corinne Houart, for her lovely in situ protocol and many discussions.
Silke Hein helped greatly in final stages of this work. M.B. was supported by a
Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Klaus
full_name: Lun, Klaus
last_name: Lun
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
1996;123(1):179-190. doi:10.1242/dev.123.1.179
apa: Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.179
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle,
Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish
Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.”
Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.179 .
ieee: M. Brand et al., “Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain,” Development, vol. 123,
no. 1. Company of Biologists, pp. 179–190, 1996.
ista: Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato
M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.
mla: Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation
of the Boundary between Midbrain and Hindbrain.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 179–90, doi:10.1242/dev.123.1.179 .
short: M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki,
M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal,
F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T11:45:04Z
day: '01'
doi: '10.1242/dev.123.1.179 '
extern: '1'
external_id:
pmid:
- '9007239 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the
month: '12'
oa: 1
oa_version: Published Version
page: 179 - 190
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations in zebrafish genes affecting the formation of the boundary between
midbrain and hindbrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4220'
abstract:
- lang: eng
text: In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during
embryogenesis. At larval stages the caudal fin fold is replaced by four different
fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins
are formed, We have identified a total of 118 mutations affecting larval fin formation,
Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal
and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly
normal complement of adult fins, Mutations in nine genes result in an increased
or reduced size of the pectoral fins, Interestingly, in mutants of one of these
genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium
fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme
of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations
in five other genes affect adult fin but not larval fin development, Two mutants,
longfin (lof) and another longfin (alf) have generally longer fins. Stein und
bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda
(wan) mutants affect all adult fins, Finally, mutations in four genes causing
defects in embryonic skin formation will be briefly reported.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation
in the zebrafish, Danio rerio. Development. 1996;123(1):255-262. doi:10.1242/dev.123.1.255
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.255
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis
of Fin Formation in the Zebrafish, Danio Rerio.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.255
.
ieee: F. Van Eeden et al., “Genetic analysis of fin formation in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
255–262, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. 123(1), 255–262.
mla: Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 255–62, doi:10.1242/dev.123.1.255
.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T10:01:17Z
day: '01'
doi: '10.1242/dev.123.1.255 '
extern: '1'
external_id:
pmid:
- '9007245 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish
month: '12'
oa: 1
oa_version: Published Version
page: 255 - 262
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic analysis of fin formation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4222'
abstract:
- lang: eng
text: Somitogenesis is the basis of segmentation of the mesoderm in the trunk and
tail of vertebrate embryos, Two groups of mutants with defects in this patterning
process have been isolated in our screen for zygotic mutations affecting the embryonic
development of the zebrafish (Danio rerio), In mutants of the first group, boundaries
between individual somites are invisible early on, although the paraxial mesoderm
is present, Later, irregular boundaries between somites are present, Mutations
infused somites (fss) and beamter (bea) affect all somites, whereas mutations
in deadly seven (des), after eight (aei) and white tail (wit) only affect the
more posterior somites, Mutants of all genes but wit are homozygous viable and
fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest
that anteroposterior patterning within individual somites is abnormal, In the
second group of mutants, formation of the horizontal myoseptum, which separates
the dorsal and ventral part of the myotome, is reduced, Six genes have been defined
in this group (you-type genes), yea-too mutants show the most severe phenotype;
in these the adaxial cells, muscle pioneers and the primary motoneurons are affected,
in addition to the horizontal myoseptum. The horizontal myoseptum is also missing
in mutants that lack a notochord. The similarity of the somite phenotype in mutants
lacking the notochord and in the you-type mutants suggests that the genes mutated
in these two groups are involved in a signaling pathway from the notochord, important
for patterning of the somites.
acknowledgement: We would like to thank P. Ingham and T. Whitfield for valuable comments
on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J.
Eisen and R. BreMiller for the znp-1 antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 1996;123(1):153-164.
doi:10.1242/dev.123.1.153
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.153
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting
Somite Formation and Patterning in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.153.
ieee: F. Van Eeden et al., “Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 153–164, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.
mla: Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 153–64, doi:10.1242/dev.123.1.153.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 153–164.
date_created: 2018-12-11T12:07:41Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T09:29:56Z
day: '01'
doi: 10.1242/dev.123.1.153
extern: '1'
external_id:
pmid:
- '9007237 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and
month: '12'
oa: 1
oa_version: Published Version
page: 153 - 164
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1895'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting somite formation and patterning in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4292'
abstract:
- lang: eng
text: Ageing, or senescence, is a decline in state at later ages that is manifested
through a reduction in survival and fecundity. Ageing means that reproductive
prospects and hence the life history options (trade-offs) open to the organism
decline. Evolutionary theories of ageing suggest that it evolves in response to
the level of externally imposed mortality and insults to fertility, either as
part of life history optimization or as a result of mutation pressure. Several
recent empirical and theoretical studies have produced apparently anomalous results.
Some have suggested that the rate of ageing can decline at later ages, others
that demographic evidence for ageing can appear in parallel with an improvement
in state. All of these studies used measures of ageing that would not be expected
to give an accurate reflection of changes in the state of the organism with age.
We propose that Fisher's `reproductive value' is a natural measure of state at
each age, which includes prospects for both survival and reproduction. If this
measure is used, the apparently anomalous findings are not at variance with evolutionary
theories of ageing.
article_processing_charge: No
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Partridge L, Barton NH. On measuring the rate of ageing. Proceedings of
the Royal Society of London Series B Biological Sciences. 1996;263(1375):1365-1371.
doi:10.1098/rspb.1996.0200
apa: Partridge, L., & Barton, N. H. (1996). On measuring the rate of ageing.
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London. https://doi.org/10.1098/rspb.1996.0200
chicago: Partridge, Linda, and Nicholas H Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London, 1996. https://doi.org/10.1098/rspb.1996.0200.
ieee: L. Partridge and N. H. Barton, “On measuring the rate of ageing,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 263, no.
1375. Royal Society of London, pp. 1365–1371, 1996.
ista: Partridge L, Barton NH. 1996. On measuring the rate of ageing. Proceedings
of the Royal Society of London Series B Biological Sciences. 263(1375), 1365–1371.
mla: Partridge, Linda, and Nicholas H. Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 263, no. 1375, Royal Society of London, 1996, pp. 1365–71, doi:10.1098/rspb.1996.0200.
short: L. Partridge, N.H. Barton, Proceedings of the Royal Society of London Series
B Biological Sciences 263 (1996) 1365–1371.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-10-22T00:00:00Z
date_updated: 2022-07-04T12:59:56Z
day: '22'
doi: 10.1098/rspb.1996.0200
extern: '1'
intvolume: ' 263'
issue: '1375'
language:
- iso: eng
main_file_link:
- url: https://royalsocietypublishing.org/doi/abs/10.1098/rspb.1996.0200
month: '10'
oa_version: None
page: 1365 - 1371
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0950-1193
publication_status: published
publisher: Royal Society of London
publist_id: '1786'
quality_controlled: '1'
status: public
title: On measuring the rate of ageing
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 263
year: '1996'
...
---
_id: '4294'
abstract:
- lang: eng
text: 'Any sample of genes traces back to a single common ancestor. Each gene also
has other properties: its sequence, its geographic location and the phenotype
and fitness of the organism that carries it. With sexual reproduction, different
genes have different genealogies, which gives us much more information, but also
greatly complicates population genetic analysis. We review the close relation
between the distribution of genealogies and the classic theory of identity by
descent in spatially structured populations, and develop a simple diffusion approximation
to the distribution of coalescence times in a homogeneous two-dimensional habitat.
This shows that when neighbourhood size is large (as in most populations) only
a small fraction of pairs of genes are closely related, and only this fraction
gives information about current rates of gene flow. The increase of spatial dispersion
with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy
depends on the long-term history of the population; we discuss ways of inferring
this history from the concordance between genealogies across loci.'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Ian
full_name: Wilson, Ian
last_name: Wilson
citation:
ama: 'Barton NH, Wilson I. Genealogies and geography. In: New Uses for New Phylogenies.
Oxford University Press; 1996:23-56. doi:10.1098/rstb.1995.0090'
apa: Barton, N. H., & Wilson, I. (1996). Genealogies and geography. In New
uses for new phylogenies (pp. 23–56). Oxford University Press. https://doi.org/10.1098/rstb.1995.0090
chicago: Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In New
Uses for New Phylogenies, 23–56. Oxford University Press, 1996. https://doi.org/10.1098/rstb.1995.0090.
ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” in New uses for
new phylogenies, Oxford University Press, 1996, pp. 23–56.
ista: 'Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new
phylogenies. , 23–56.'
mla: Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” New Uses
for New Phylogenies, Oxford University Press, 1996, pp. 23–56, doi:10.1098/rstb.1995.0090.
short: N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University
Press, 1996, pp. 23–56.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-04T08:59:18Z
day: '01'
doi: 10.1098/rstb.1995.0090
extern: '1'
external_id:
pmid:
- '8748019'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 56
pmid: 1
publication: New uses for new phylogenies
publication_identifier:
isbn:
- 978-0198549840
publication_status: published
publisher: Oxford University Press
publist_id: '1783'
quality_controlled: '1'
status: public
title: Genealogies and geography
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4295'
abstract:
- lang: eng
text: Genetic studies are beginning to provide insights into the evolutionary processes
that reduce the fitness of hybrids between recently diverged species. However,
the deleterious gene interactions responsible for this fitness reduction are still
poorly understood.
acknowledgement: Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael
Turelli for their comments on this note, and to the BBSRC and NERC for financial
support.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Speciation: more than the sum of its parts. In: Current Biology.
Vol 6. Cell Press; 1996:1244-1246. doi:10.1016/S0960-9822(02)70707-0'
apa: 'Barton, N. H. (1996). Speciation: more than the sum of its parts. In Current
Biology (Vol. 6, pp. 1244–1246). Cell Press. https://doi.org/10.1016/S0960-9822(02)70707-0'
chicago: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In Current
Biology, 6:1244–46. Cell Press, 1996. https://doi.org/10.1016/S0960-9822(02)70707-0.'
ieee: 'N. H. Barton, “Speciation: more than the sum of its parts,” in Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–1246.'
ista: 'Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology.
vol. 6, 1244–1246.'
mla: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–46, doi:10.1016/S0960-9822(02)70707-0.'
short: N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.
date_created: 2018-12-11T12:08:06Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2022-07-07T09:28:28Z
day: '01'
doi: 10.1016/S0960-9822(02)70707-0
extern: '1'
external_id:
pmid:
- '8939554'
intvolume: ' 6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub
month: '10'
oa: 1
oa_version: Published Version
page: 1244 - 1246
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Speciation: more than the sum of its parts'
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1996'
...
---
_id: '4419'
abstract:
- lang: eng
text: A {\em hybrid automaton\/} consists of a finite automaton interacting with
a dynamical system. Hybrid automata are used to model embedded controllers and
other systems that consist of interacting discrete and continuous components.
A hybrid automaton is {\em rectangular\/} if each of its continuous variables~x
satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where
a and~b are rational constants. Rectangular hybrid automata are particularly useful
for the analysis of communication protocols in which local clocks have bounded
drift, and for the conservative approximation of systems with more complex continuous
behavior. We examine several verification problems on the class of rectangular
hybrid automata, including reachability, temporal logic model checking, and controller
synthesis. Both dense-time and discrete-time models are considered. We identify
subclasses of rectangular hybrid automata for which these problems are decidable
and give complexity analyses. An investigation of the structural properties of
rectangular hybrid automata is undertaken. One method for proving the decidability
of verification problems on infinite-state systems is to find finite quotient
systems on which analysis can proceed. Three state-space equivalence relations
with strong connections to temporal logic are bisimilarity, similarity, and language
equivalence. We characterize the quotient spaces of rectangular hybrid automata
with respect to these equivalence relations.
article_processing_charge: No
author:
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: Kopke P. The Theory of Rectangular Hybrid Automata. 1996.
apa: Kopke, P. (1996). The Theory of Rectangular Hybrid Automata. Cornell
University.
chicago: Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University,
1996.
ieee: P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University,
1996.
ista: Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.
mla: Kopke, Peter. The Theory of Rectangular Hybrid Automata. Cornell University,
1996.
short: P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University,
1996.
date_created: 2018-12-11T12:08:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T15:11:24Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication_status: published
publisher: Cornell University
publist_id: '312'
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: The Theory of Rectangular Hybrid Automata
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4426'
abstract:
- lang: eng
text: We use linear hybrid automata to define linear approximations of the phase
portraits of nonlinear hybrid systems. The approximating automata can be analyzed
automatically using the symbolic model checker HyTech. We demonstrate the technique
through the study of predator-prey systems, where we compute population bounds
for both species. We also identify a class of nonlinear hybrid automata for which
linear phase-portrait approximations can be generated automatically.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grants CCR-9200794 and CCR-9504469,
by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Wong Toi H. Linear phase-portrait approximations for nonlinear
hybrid systems. In: Alur R, Henzinger TA, Sontag E, eds. Hybrid Systems III:
Verification and Control. Vol 1066. Springer; 1996:377-388. doi:10.1007/BFb0020961'
apa: 'Henzinger, T. A., & Wong Toi, H. (1996). Linear phase-portrait approximations
for nonlinear hybrid systems. In R. Alur, T. A. Henzinger, & E. Sontag (Eds.),
Hybrid Systems III: Verification and Control (Vol. 1066, pp. 377–388).
Springer. https://doi.org/10.1007/BFb0020961'
chicago: 'Henzinger, Thomas A, and Howard Wong Toi. “Linear Phase-Portrait Approximations
for Nonlinear Hybrid Systems.” In Hybrid Systems III: Verification and Control,
edited by Rajeev Alur, Thomas A Henzinger, and Eduardo Sontag, 1066:377–88. Springer,
1996. https://doi.org/10.1007/BFb0020961.'
ieee: 'T. A. Henzinger and H. Wong Toi, “Linear phase-portrait approximations for
nonlinear hybrid systems,” in Hybrid Systems III: Verification and Control,
1996, vol. 1066, pp. 377–388.'
ista: 'Henzinger TA, Wong Toi H. 1996. Linear phase-portrait approximations for
nonlinear hybrid systems. Hybrid Systems III: Verification and Control. , LNCS,
vol. 1066, 377–388.'
mla: 'Henzinger, Thomas A., and Howard Wong Toi. “Linear Phase-Portrait Approximations
for Nonlinear Hybrid Systems.” Hybrid Systems III: Verification and Control,
edited by Rajeev Alur et al., vol. 1066, Springer, 1996, pp. 377–88, doi:10.1007/BFb0020961.'
short: 'T.A. Henzinger, H. Wong Toi, in:, R. Alur, T.A. Henzinger, E. Sontag (Eds.),
Hybrid Systems III: Verification and Control, Springer, 1996, pp. 377–388.'
date_created: 2018-12-11T12:08:47Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T09:58:25Z
day: '01'
doi: 10.1007/BFb0020961
editor:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
last_name: Henzinger
- first_name: Eduardo
full_name: Sontag, Eduardo
last_name: Sontag
extern: '1'
intvolume: ' 1066'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0020961
month: '01'
oa_version: None
page: 377 - 388
publication: 'Hybrid Systems III: Verification and Control'
publication_identifier:
isbn:
- '9783540611554'
publication_status: published
publisher: Springer
publist_id: '302'
quality_controlled: '1'
status: public
title: Linear phase-portrait approximations for nonlinear hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1066
year: '1996'
...
---
_id: '4427'
abstract:
- lang: eng
text: We model a steam-boiler control system using hybrid automata. We provide two
abstracted linear models of the nonlinear behavior of the boiler. For each model,
we define and verify a controller that maintains safe operation of the boiler.
The less abstract model permits the design of a more efficient controller. We
also demonstrate how the tool HyTech can be used to automatically synthesize control
parameter constraints that guarantee safety of the boiler.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Wong Toi H. Using HyTech to synthesize control parameters for
a steam boiler. In: Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control. Vol 1165. Springer; 1996:265-282.
doi:10.1007/BFb0027241'
apa: 'Henzinger, T. A., & Wong Toi, H. (1996). Using HyTech to synthesize control
parameters for a steam boiler. In Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control (Vol. 1165, pp. 265–282).
Springer. https://doi.org/10.1007/BFb0027241'
chicago: 'Henzinger, Thomas A, and Howard Wong Toi. “Using HyTech to Synthesize
Control Parameters for a Steam Boiler.” In Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, 1165:265–82. Springer,
1996. https://doi.org/10.1007/BFb0027241.'
ieee: 'T. A. Henzinger and H. Wong Toi, “Using HyTech to synthesize control parameters
for a steam boiler,” in Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control, vol. 1165, Springer, 1996, pp. 265–282.'
ista: 'Henzinger TA, Wong Toi H. 1996.Using HyTech to synthesize control parameters
for a steam boiler. In: Formal Methods for Industrial Applications: Specifying
and Programming the Steam Boiler Control. LNCS, vol. 1165, 265–282.'
mla: 'Henzinger, Thomas A., and Howard Wong Toi. “Using HyTech to Synthesize Control
Parameters for a Steam Boiler.” Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, vol. 1165, Springer,
1996, pp. 265–82, doi:10.1007/BFb0027241.'
short: 'T.A. Henzinger, H. Wong Toi, in:, Formal Methods for Industrial Applications:
Specifying and Programming the Steam Boiler Control, Springer, 1996, pp. 265–282.'
date_created: 2018-12-11T12:08:48Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T10:06:19Z
day: '01'
doi: 10.1007/BFb0027241
extern: '1'
intvolume: ' 1165'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0027241
month: '01'
oa_version: None
page: 265 - 282
publication: 'Formal Methods for Industrial Applications: Specifying and Programming
the Steam Boiler Control'
publication_identifier:
isbn:
- '9783540495666'
publication_status: published
publisher: Springer
publist_id: '303'
quality_controlled: '1'
status: public
title: Using HyTech to synthesize control parameters for a steam boiler
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1165
year: '1996'
...
---
_id: '4443'
abstract:
- lang: eng
text: "Three natural equivalence relations on the infinite state space of a hybrid
automaton are language equivalence, simulation equivalence, and bisimulation equivalence.
When one of these equivalence relations has a finite quotient, certain model checking
and controller synthesis problems are decidable. When bounds on the number of
equivalence classes are obtained, bounds on the running times of model checking
and synthesis algorithms follow as corollaries.\r\nWe characterize the time-abstract
versions of these equivalence relations on the state spaces of rectangular hybrid
automata (RHA), in which each continuous variable is a clock with bounded drift.
These automata are useful for modeling communications protocols with drifting
local clocks, and for the conservative approximation of more complex hybrid systems.
Of our two main results, one has positive implications for automatic verification,
and the other has negative implications. On the positive side, we find that the
(finite) language equivalence quotient for RHA is coarser than was previously
known by a multiplicative exponential factor. On the negative side, we show that
simulation equivalence for RHA is equality (which obviously has an infinite quotient).\r\nOur
main positive result is established by analyzing a subclass of timed automata,
called one-sided timed automata (OTA), for which the language equivalence quotient
is coarser than for the class of all timed automata. An exact characterization
of language equivalence for OTA requires a distinction between synchronous and
asynchronous definitions of (bi)simulation: if time actions are silent, then the
induced quotient for OTA is coarser than if time actions (but not their durations)
are visible."
acknowledgement: This research was supported in part by ONR Young Investigator award
N00014-95-1-0520, by NSF CAREER award CCR-9501708, by NSF grant CCR-9504469, by
Air Force Office of Scientific Research contract F49620-93-1-0056, by ARPA grant
NAG2-892, and by the U.S. Army Research Office through the Mathematical Sciences
Institute of Cornell University, Contract Number DAAL03-91-C-0027.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: 'Henzinger TA, Kopke P. State equivalences for rectangular hybrid automata.
In: 7th International Conference on Concurrency Theory. Vol 1119. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 1996:530-545. doi:10.1007/3-540-61604-7_74'
apa: 'Henzinger, T. A., & Kopke, P. (1996). State equivalences for rectangular
hybrid automata. In 7th International Conference on Concurrency Theory
(Vol. 1119, pp. 530–545). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für
Informatik. https://doi.org/10.1007/3-540-61604-7_74'
chicago: Henzinger, Thomas A, and Peter Kopke. “State Equivalences for Rectangular
Hybrid Automata.” In 7th International Conference on Concurrency Theory,
1119:530–45. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996. https://doi.org/10.1007/3-540-61604-7_74.
ieee: T. A. Henzinger and P. Kopke, “State equivalences for rectangular hybrid automata,”
in 7th International Conference on Concurrency Theory, Pisa, Italy, 1996,
vol. 1119, pp. 530–545.
ista: 'Henzinger TA, Kopke P. 1996. State equivalences for rectangular hybrid automata.
7th International Conference on Concurrency Theory. CONCUR: Concurrency Theory,
LNCS, vol. 1119, 530–545.'
mla: Henzinger, Thomas A., and Peter Kopke. “State Equivalences for Rectangular
Hybrid Automata.” 7th International Conference on Concurrency Theory, vol.
1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–45, doi:10.1007/3-540-61604-7_74.
short: T.A. Henzinger, P. Kopke, in:, 7th International Conference on Concurrency
Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–545.
conference:
end_date: 1996-08-29
location: Pisa, Italy
name: 'CONCUR: Concurrency Theory'
start_date: 1996-08-26
date_created: 2018-12-11T12:08:52Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T08:43:23Z
day: '01'
doi: 10.1007/3-540-61604-7_74
extern: '1'
intvolume: ' 1119'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-61604-7_74
month: '01'
oa_version: None
page: 530 - 545
publication: 7th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540616047'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '288'
quality_controlled: '1'
status: public
title: State equivalences for rectangular hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1119
year: '1996'
...
---
_id: '4495'
abstract:
- lang: eng
text: In temporal-logic model checking, we verify the correctness of a program with
respect to a desired behavior by checking whether a structure that models the
program satisfies a temporal-logic formula that specifies the behavior. The main
practical limitation of model checking is caused by the size of the state space
of the program, which grows exponentially with the number of concurrent components.
This problem, known as the state-explosion problem, becomes more difficult when
we consider real-time model checking, where the program and the specification
involve quantitative references to time. In particular, when use timed automata
to describe real-time programs and we specify timed behaviors in the logic TCTL,
a real-time extension of the temporal logic CTL with clock variables, then the
state space under consideration grows exponentially not only with the number of
concurrent components, but also with the number of clocks and the length of the
clock constraints used in the program and the specification. Two powerful methods
for coping with the state-explosion problem are on-the-fly and space-efficient
model checking. In on-the-fly model checking, we explore only the portion of the
state space of the program whose exploration is essential for determining the
satisfaction of the specification. In space-efficient model checking, we store
in memory the minimal information required, preferring to spend time on reconstructing
information rather than spend space on storing it. In this work we develop an
automata-theoretic approach to TCTL model checking that combines both methods.
We suggest, for the first time, a PSPACE on-the-fly model-checking algorithm for
TCTL.
acknowledgement: Supported in part by the ONR YIP award N00014-95-1-0520, by the NSF
CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR contract F49620-93-1-0056,
and by the ARPA grant NAG2-892.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
- first_name: Moshe
full_name: Vardi, Moshe
last_name: Vardi
citation:
ama: 'Henzinger TA, Kupferman O, Vardi M. A space-efficient on-the-fly algorithm
for real-time model checking. In: 7th International Conference on Concurrency
Theory. Vol 1119. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1996:514-529.
doi:10.1007/3-540-61604-7_73'
apa: 'Henzinger, T. A., Kupferman, O., & Vardi, M. (1996). A space-efficient
on-the-fly algorithm for real-time model checking. In 7th International Conference
on Concurrency Theory (Vol. 1119, pp. 514–529). Pisa, Italy: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-61604-7_73'
chicago: Henzinger, Thomas A, Orna Kupferman, and Moshe Vardi. “A Space-Efficient
on-the-Fly Algorithm for Real-Time Model Checking.” In 7th International Conference
on Concurrency Theory, 1119:514–29. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 1996. https://doi.org/10.1007/3-540-61604-7_73.
ieee: T. A. Henzinger, O. Kupferman, and M. Vardi, “A space-efficient on-the-fly
algorithm for real-time model checking,” in 7th International Conference on
Concurrency Theory, Pisa, Italy, 1996, vol. 1119, pp. 514–529.
ista: 'Henzinger TA, Kupferman O, Vardi M. 1996. A space-efficient on-the-fly algorithm
for real-time model checking. 7th International Conference on Concurrency Theory.
CONCUR: Concurrency Theory, LNCS, vol. 1119, 514–529.'
mla: Henzinger, Thomas A., et al. “A Space-Efficient on-the-Fly Algorithm for Real-Time
Model Checking.” 7th International Conference on Concurrency Theory, vol.
1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 514–29, doi:10.1007/3-540-61604-7_73.
short: T.A. Henzinger, O. Kupferman, M. Vardi, in:, 7th International Conference
on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996,
pp. 514–529.
conference:
end_date: 1996-08-29
location: Pisa, Italy
name: 'CONCUR: Concurrency Theory'
start_date: 1996-08-26
date_created: 2018-12-11T12:09:08Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T08:21:20Z
day: '01'
doi: 10.1007/3-540-61604-7_73
extern: '1'
intvolume: ' 1119'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-61604-7_73
month: '01'
oa_version: None
page: 514 - 529
publication: 7th International Conference on Concurrency Theory
publication_identifier:
isbn:
- 978-3-540-70625-0
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '233'
quality_controlled: '1'
status: public
title: A space-efficient on-the-fly algorithm for real-time model checking
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1119
year: '1996'
...
---
_id: '4519'
abstract:
- lang: eng
text: We summarize several recent results about hybrid automata. Our goal is to
demonstrate that concepts from the theory of discrete concurrent systems can give
insights into partly continuous systems, and that methods for the verification
of finite-state systems can be used to analyze certain systems with uncountable
state spaces
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Henzinger TA. The theory of hybrid automata. In: Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science. IEEE; 1996:278-292. doi:10.1109/LICS.1996.561342 '
apa: 'Henzinger, T. A. (1996). The theory of hybrid automata. In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science (pp. 278–292). New
Brunswick, NJ, United States of America: IEEE. https://doi.org/10.1109/LICS.1996.561342 '
chicago: Henzinger, Thomas A. “The Theory of Hybrid Automata.” In Proceedings
11th Annual IEEE Symposium on Logic in Computer Science, 278–92. IEEE, 1996.
https://doi.org/10.1109/LICS.1996.561342
.
ieee: T. A. Henzinger, “The theory of hybrid automata,” in Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science, New Brunswick, NJ, United States
of America, 1996, pp. 278–292.
ista: 'Henzinger TA. 1996. The theory of hybrid automata. Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science,
278–292.'
mla: Henzinger, Thomas A. “The Theory of Hybrid Automata.” Proceedings 11th Annual
IEEE Symposium on Logic in Computer Science, IEEE, 1996, pp. 278–92, doi:10.1109/LICS.1996.561342 .
short: T.A. Henzinger, in:, Proceedings 11th Annual IEEE Symposium on Logic in Computer
Science, IEEE, 1996, pp. 278–292.
conference:
end_date: 1996-07-30
location: New Brunswick, NJ, United States of America
name: 'LICS: Logic in Computer Science'
start_date: 1996-07-27
date_created: 2018-12-11T12:09:16Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T07:56:28Z
day: '01'
doi: '10.1109/LICS.1996.561342 '
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/561342
month: '01'
oa_version: None
page: 278 - 292
publication: Proceedings 11th Annual IEEE Symposium on Logic in Computer Science
publication_identifier:
issn:
- 1043-6871
publication_status: published
publisher: IEEE
publist_id: '213'
quality_controlled: '1'
status: public
title: The theory of hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '2465'
abstract:
- lang: eng
text: Auxins play a crucial role in the regulation of spatial and temporal aspects
of plant growth and development1. As well as being required for the division,
enlargement and differentiation of individual plant cells, auxins also function
as signals between cells, tissues and organs. In this way they contribute to the
coordination and integration of growth and development in the whole plant and
to physiological responses of plants to environmental cues (63). At the individual
cell level, fast changes or pulses in hormone concentration may function to initiate
or to terminate a developmental process. In contrast, the maintenance of a stable
concentration of the hormone (homeostasis) may be necessary to maintain the progress
of a developmental event that has already been initiated.
article_processing_charge: No
author:
- first_name: David
full_name: Morris, David
last_name: Morris
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Eva
full_name: Zažímalová, Eva
last_name: Zažímalová
citation:
ama: 'Morris D, Friml J, Zažímalová E. Auxin transport. In: Davies P, ed. Plant
Hormones: Biosynthesis, Signal Transduction, Action!. Kluwer; 1995:451-484.
doi:10.1007/978-1-4020-2686-7_21'
apa: 'Morris, D., Friml, J., & Zažímalová, E. (1995). Auxin transport. In P.
Davies (Ed.), Plant Hormones: Biosynthesis, Signal Transduction, Action!
(pp. 451–484). Kluwer. https://doi.org/10.1007/978-1-4020-2686-7_21'
chicago: 'Morris, David, Jiří Friml, and Eva Zažímalová. “Auxin Transport.” In Plant
Hormones: Biosynthesis, Signal Transduction, Action!, edited by Peter Davies,
451–84. Kluwer, 1995. https://doi.org/10.1007/978-1-4020-2686-7_21.'
ieee: 'D. Morris, J. Friml, and E. Zažímalová, “Auxin transport,” in Plant Hormones:
Biosynthesis, Signal Transduction, Action!, P. Davies, Ed. Kluwer, 1995, pp.
451–484.'
ista: 'Morris D, Friml J, Zažímalová E. 1995.Auxin transport. In: Plant Hormones:
Biosynthesis, Signal Transduction, Action! , 451–484.'
mla: 'Morris, David, et al. “Auxin Transport.” Plant Hormones: Biosynthesis,
Signal Transduction, Action!, edited by Peter Davies, Kluwer, 1995, pp. 451–84,
doi:10.1007/978-1-4020-2686-7_21.'
short: 'D. Morris, J. Friml, E. Zažímalová, in:, P. Davies (Ed.), Plant Hormones:
Biosynthesis, Signal Transduction, Action!, Kluwer, 1995, pp. 451–484.'
date_created: 2018-12-11T11:57:49Z
date_published: 1995-01-01T00:00:00Z
date_updated: 2022-06-29T14:45:32Z
day: '01'
doi: 10.1007/978-1-4020-2686-7_21
editor:
- first_name: Peter
full_name: Davies, Peter
last_name: Davies
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-1-4020-2686-7_21
month: '01'
oa_version: None
page: 451 - 484
publication: 'Plant Hormones: Biosynthesis, Signal Transduction, Action!'
publication_identifier:
isbn:
- 978-1-4020-2684-3
publication_status: published
publisher: Kluwer
publist_id: '4438'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin transport
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1995'
...
---
_id: '2491'
abstract:
- lang: eng
text: The distribution of mRNAs for metabotropic glutamate receptors, mGluR4 and
mGluR7, which are highly sensitive for L-2-amino-4-phosphonobutyrate (L- AP4),
was examined in the central nervous system of the rat by in situ hybridization.
In general, the hybridization signals of mGluR7 mRNA were more widely distributed
than those of mGluR4 mRNA, and differential expression of mGluR4 mRNA and mGluR7
mRNA was clearly indicated in some brain regions. Intense or moderate expression
of mGluR4 mRNA was detected in the granule cells of the olfactory bulb and cerebellum,
whereas no significant expression of mGluR7 mRNA was found in these cells. In
other neurons or regions where mGluR7 mRNA was intensely or moderately expressed,
no significant expression of mGluR4 mRNA was observed. Such were the mitral and
tufted cells of the olfactory bulb; anterior olfactory nucleus; neocortical regions;
cingulate cortex; retrosplenial cortex; piriform cortex; perirhinal cortex; CA1;
CA3; granule cells of the dentate gyrus; superficial layers of the subicular cortex;
deep layers of the entorhinal, parasubicular, and presubicular cortices; ventral
part of the lateral septal nucleus; septohippocampal nucleus; triangular septal
nucleus; nuclei of the diagonal band; bed nucleus of the stria terminalis; ventral
pallidum; claustrum; amygdaloid nuclei other than the intercalated nuclei; preoptic
region; hypothalamic nuclei other than the medial mammillary nucleus; ventral
lateral geniculate nucleus; locus coeruleus; Purkinje cells; many nuclei of the
lower brainstem other than the superior colliculus, periaqueductal gray, interpeduncular
nucleus, pontine nuclei, and dorsal cochlear nucleus; and dorsal horn of the spinal
cord. Both mGluR4 mRNA and mGluR7 mRNA were moderately or intensely expressed
in the olfactory tubercle, superficial layers of the entorhinal cortex, CA4, septofimbrial
nucleus, intercalated nuclei of the amygdala, medial mammillary nucleus, many
thalamic nuclei, and pontine nuclei. Intense expression of both mGluR4 mRNA and
mGluR7 mRNA was further detected in the trigeminal ganglion and dorsal root ganglia,
whereas no significant expression of them was found in the pterygopalatine ganglion
and superior cervical ganglion. The results indicate differential roles of the
L-AP4-sensitive metabotropic glutamate receptors in the glutamatergic nervous
system.
acknowledgement: We are grateful to Akira Uesugi for photographic help. This work
has been supported in part by research grants from the Ministry of Education, Science
and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ohishi H, Akazawa C, Shigemoto R, Nakanishi S, Mizuno N. Distributions of the
mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors,
mGluR4 and mGluR7, in the rat brain. Journal of Comparative Neurology.
1995;360(4):555-570. doi:10.1002/cne.903600402
apa: Ohishi, H., Akazawa, C., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1995).
Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic
glutamate receptors, mGluR4 and mGluR7, in the rat brain. Journal of Comparative
Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.903600402
chicago: Ohishi, Hitoshi, Chihiro Akazawa, Ryuichi Shigemoto, Shigetada Nakanishi,
and Noboru Mizuno. “Distributions of the MRNAs for L-2-Amino-4-Phosphonobutyrate-Sensitive
Metabotropic Glutamate Receptors, MGluR4 and MGluR7, in the Rat Brain.” Journal
of Comparative Neurology. Wiley-Blackwell, 1995. https://doi.org/10.1002/cne.903600402.
ieee: H. Ohishi, C. Akazawa, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distributions
of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate
receptors, mGluR4 and mGluR7, in the rat brain,” Journal of Comparative Neurology,
vol. 360, no. 4. Wiley-Blackwell, pp. 555–570, 1995.
ista: Ohishi H, Akazawa C, Shigemoto R, Nakanishi S, Mizuno N. 1995. Distributions
of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate
receptors, mGluR4 and mGluR7, in the rat brain. Journal of Comparative Neurology.
360(4), 555–570.
mla: Ohishi, Hitoshi, et al. “Distributions of the MRNAs for L-2-Amino-4-Phosphonobutyrate-Sensitive
Metabotropic Glutamate Receptors, MGluR4 and MGluR7, in the Rat Brain.” Journal
of Comparative Neurology, vol. 360, no. 4, Wiley-Blackwell, 1995, pp. 555–70,
doi:10.1002/cne.903600402.
short: H. Ohishi, C. Akazawa, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of
Comparative Neurology 360 (1995) 555–570.
date_created: 2018-12-11T11:57:59Z
date_published: 1995-10-02T00:00:00Z
date_updated: 2022-06-29T13:08:19Z
day: '02'
doi: 10.1002/cne.903600402
extern: '1'
external_id:
pmid:
- '8801249'
intvolume: ' 360'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.903600402
month: '10'
oa_version: None
page: 555 - 570
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4410'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic
glutamate receptors, mGluR4 and mGluR7, in the rat brain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 360
year: '1995'
...
---
_id: '2556'
abstract:
- lang: eng
text: By using substance P receptor (SPR) immunofluorescence histochemistry combined
with fluorescent retrograde labeling, SPR-like immunoreactive (SPR-LI) neurons
sending their axons to the lateral parabrachial region were observed in the lumbar
spinal cord of the rat. After injection of Fluoro-Gold into the lateral parabrachial
region, retrogradely labeled neurons with SPR-LI were seen frequently in lamina
I and the lateral spinal nucleus, and occasionally in laminae IV and V, with a
predominantly contralateral distribution. Some of these neurons, especially those
in lamina I, may convey nociceptive information to the lateral parabrachial region.
acknowledgement: The authors are grateful for photographic help of Mr. Akira Uesugi.
This work was supported in part by Grants-in-Aid for Special Research on Priority
Areas 05267104, Scientific Research (B) 05454658, and Scientific Research (C) 06680735
from the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Takada M, Shigemoto R, Mizuno N. Spinoparabrachial tract neurons showing
substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat.
Brain Research. 1995;674(2):336-340. doi:10.1016/0006-8993(95)00022-I
apa: Ding, Y., Takada, M., Shigemoto, R., & Mizuno, N. (1995). Spinoparabrachial
tract neurons showing substance P receptor-like immunoreactivity in the lumbar
spinal cord of the rat. Brain Research. Elsevier. https://doi.org/10.1016/0006-8993(95)00022-I
chicago: Ding, Yu, Masahiko Takada, Ryuichi Shigemoto, and Noboru Mizuno. “Spinoparabrachial
Tract Neurons Showing Substance P Receptor-like Immunoreactivity in the Lumbar
Spinal Cord of the Rat.” Brain Research. Elsevier, 1995. https://doi.org/10.1016/0006-8993(95)00022-I.
ieee: Y. Ding, M. Takada, R. Shigemoto, and N. Mizuno, “Spinoparabrachial tract
neurons showing substance P receptor-like immunoreactivity in the lumbar spinal
cord of the rat,” Brain Research, vol. 674, no. 2. Elsevier, pp. 336–340,
1995.
ista: Ding Y, Takada M, Shigemoto R, Mizuno N. 1995. Spinoparabrachial tract neurons
showing substance P receptor-like immunoreactivity in the lumbar spinal cord of
the rat. Brain Research. 674(2), 336–340.
mla: Ding, Yu, et al. “Spinoparabrachial Tract Neurons Showing Substance P Receptor-like
Immunoreactivity in the Lumbar Spinal Cord of the Rat.” Brain Research,
vol. 674, no. 2, Elsevier, 1995, pp. 336–40, doi:10.1016/0006-8993(95)00022-I.
short: Y. Ding, M. Takada, R. Shigemoto, N. Mizuno, Brain Research 674 (1995) 336–340.
date_created: 2018-12-11T11:58:22Z
date_published: 1995-03-20T00:00:00Z
date_updated: 2022-06-29T08:32:01Z
day: '20'
doi: 10.1016/0006-8993(95)00022-I
extern: '1'
external_id:
pmid:
- '7796113'
intvolume: ' 674'
issue: '2'
language:
- iso: eng
main_file_link:
- url: sciencedirect.com/science/article/pii/000689939500022I?via%3Dihub
month: '03'
oa_version: None
page: 336 - 340
pmid: 1
publication: Brain Research
publication_identifier:
issn:
- 0006-8993
publication_status: published
publisher: Elsevier
publist_id: '4341'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity
in the lumbar spinal cord of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 674
year: '1995'
...
---
_id: '2558'
abstract:
- lang: eng
text: Brain areas involved in the genesis and control of daily rhythms receive a
prominent neural input that contains the neurotransmitter substance P (SP), a
peptide putatively involved in the synchronization of circadian rhythms by environmental
light. We investigated the localization of receptors to SP in the suprachiasmatic
nucleus of the hypothalamus (SCN) and in the intergeniculate leaflet of the thalamus
(IGL) of the rat and hamster using in situ hybridization histochemistry and immunohistochemistry.
Consistently with that previously described in the rat, a neuronal population
distributed along the lateral margin and at the dorso-latero-caudal aspect of
the hamster SCN expresses moderately the mRNA encoding the SP receptor. In both
rat and hamster, immunohistochemical data confirm the previous finding and reveal
an almost complete absence of SP receptors in the ventral part of the SCN, which
receives a direct projection from the retina. In the IGL of both species, numerous
neurons prominently express the mRNA encoding the SP receptor. The immunostaining
shows a high density of SP receptors on perikarya and dendrites throughout the
nucleus. A dense staining is also observed on individual cells and processes bordering
the lumen of blood vessels in the SCN and IGL.
article_processing_charge: No
article_type: original
author:
- first_name: Gérard
full_name: Mick, Gérard
last_name: Mick
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kunio
full_name: Kitahama, Kunio
last_name: Kitahama
citation:
ama: Mick G, Shigemoto R, Kitahama K. Localization of substance P receptors in central
neural structures controlling daily rhythms in nocturnal rodents. Comptes Rendus
de l’Academie des Sciences - Series III. 1995;318(2):209-217.
apa: Mick, G., Shigemoto, R., & Kitahama, K. (1995). Localization of substance
P receptors in central neural structures controlling daily rhythms in nocturnal
rodents. Comptes Rendus de l’Academie Des Sciences - Series III. Gauthier
Villars Editeur.
chicago: Mick, Gérard, Ryuichi Shigemoto, and Kunio Kitahama. “Localization of Substance
P Receptors in Central Neural Structures Controlling Daily Rhythms in Nocturnal
Rodents.” Comptes Rendus de l’Academie Des Sciences - Series III. Gauthier
Villars Editeur, 1995.
ieee: G. Mick, R. Shigemoto, and K. Kitahama, “Localization of substance P receptors
in central neural structures controlling daily rhythms in nocturnal rodents,”
Comptes Rendus de l’Academie des Sciences - Series III, vol. 318, no. 2.
Gauthier Villars Editeur, pp. 209–217, 1995.
ista: Mick G, Shigemoto R, Kitahama K. 1995. Localization of substance P receptors
in central neural structures controlling daily rhythms in nocturnal rodents. Comptes
Rendus de l’Academie des Sciences - Series III. 318(2), 209–217.
mla: Mick, Gérard, et al. “Localization of Substance P Receptors in Central Neural
Structures Controlling Daily Rhythms in Nocturnal Rodents.” Comptes Rendus
de l’Academie Des Sciences - Series III, vol. 318, no. 2, Gauthier Villars
Editeur, 1995, pp. 209–17.
short: G. Mick, R. Shigemoto, K. Kitahama, Comptes Rendus de l’Academie Des Sciences
- Series III 318 (1995) 209–217.
date_created: 2018-12-11T11:58:23Z
date_published: 1995-02-01T00:00:00Z
date_updated: 2022-06-29T08:18:48Z
day: '01'
extern: '1'
external_id:
pmid:
- '7757814 '
intvolume: ' 318'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://pubmed.ncbi.nlm.nih.gov/7757814/
month: '02'
oa_version: None
page: 209 - 217
pmid: 1
publication: Comptes Rendus de l'Academie des Sciences - Series III
publication_identifier:
issn:
- 0764-4469
publication_status: published
publisher: Gauthier Villars Editeur
publist_id: '4340'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of substance P receptors in central neural structures controlling
daily rhythms in nocturnal rodents
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 318
year: '1995'
...
---
_id: '2559'
abstract:
- lang: eng
text: Taking advantage of the restricted expression of metabotropic glutamate receptor
subtype 6 (mGIuR6) in retinal ON bipolar cells, we generated knockout mice lacking
mGIuR6 expression. The homozygous mutant mice showed a loss of ON responses but
unchanged OFF responses to light. The mutant mice displayed no obvious changes
in retinal cell organization nor in the projection of optic fibers to the brain.
Furthermore, the mGIuR6-deficient mice showed visual behavioral responses to light
stimulation as examined by shuttle box avoidance behavior experiments using light
exposure as a conditioned stimulus. The results demonstrate that mGIuR6 is essential
in synaptic transmission to the ON bipolar cell and that the OFF response provides
an important means for transmitting visual information.
acknowledgement: We thank Drs. N. Mizuno, M. Iso, M. Tachibana, A. Kaneko, M. Tessier-Lavigne,
and T. Hensch for useful advice and A. Uesugi for photographic assistance. This
work is supported by grants in aid for specially promoted research, for scientific
research on priority areas, and for scientific research (A) from the Ministry of
Education, Science, and Culture in Japan and by grants from the Ministry of Health
and Welfare of Japan, the Sankyo Foundation, and the Senri Life Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Hideki
full_name: Iwakabe, Hideki
last_name: Iwakabe
- first_name: Yoshiaki
full_name: Tagawa, Yoshiaki
last_name: Tagawa
- first_name: Tomomitsu
full_name: Miyoshi, Tomomitsu
last_name: Miyoshi
- first_name: Masayuki
full_name: Yamashita, Masayuki
last_name: Yamashita
- first_name: Yutaka
full_name: Fukuda, Yutaka
last_name: Fukuda
- first_name: Hitoshi
full_name: Sasaki, Hitoshi
last_name: Sasaki
- first_name: Kano
full_name: Hiroi, Kano
last_name: Hiroi
- first_name: Yasuhisa
full_name: Nakamura, Yasuhisa
last_name: Nakamura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Kenji
full_name: Nakamura, Kenji
last_name: Nakamura
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Masu M, Iwakabe H, Tagawa Y, et al. Specific deficit of the ON response in
visual transmission by targeted disruption of the mGIuR6 gene. Cell. 1995;80(5):757-765.
doi:10.1016/0092-8674(95)90354-2
apa: Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y.,
… Nakanishi, S. (1995). Specific deficit of the ON response in visual transmission
by targeted disruption of the mGIuR6 gene. Cell. Cell Press. https://doi.org/10.1016/0092-8674(95)90354-2
chicago: Masu, Masayuki, Hideki Iwakabe, Yoshiaki Tagawa, Tomomitsu Miyoshi, Masayuki
Yamashita, Yutaka Fukuda, Hitoshi Sasaki, et al. “Specific Deficit of the ON Response
in Visual Transmission by Targeted Disruption of the MGIuR6 Gene.” Cell.
Cell Press, 1995. https://doi.org/10.1016/0092-8674(95)90354-2.
ieee: M. Masu et al., “Specific deficit of the ON response in visual transmission
by targeted disruption of the mGIuR6 gene,” Cell, vol. 80, no. 5. Cell
Press, pp. 757–765, 1995.
ista: Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi
K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi
S. 1995. Specific deficit of the ON response in visual transmission by targeted
disruption of the mGIuR6 gene. Cell. 80(5), 757–765.
mla: Masu, Masayuki, et al. “Specific Deficit of the ON Response in Visual Transmission
by Targeted Disruption of the MGIuR6 Gene.” Cell, vol. 80, no. 5, Cell
Press, 1995, pp. 757–65, doi:10.1016/0092-8674(95)90354-2.
short: M. Masu, H. Iwakabe, Y. Tagawa, T. Miyoshi, M. Yamashita, Y. Fukuda, H. Sasaki,
K. Hiroi, Y. Nakamura, R. Shigemoto, M. Takada, K. Nakamura, K. Nakao, M. Katsuki,
S. Nakanishi, Cell 80 (1995) 757–765.
date_created: 2018-12-11T11:58:23Z
date_published: 1995-02-10T00:00:00Z
date_updated: 2022-06-28T13:27:50Z
day: '10'
doi: 10.1016/0092-8674(95)90354-2
extern: '1'
external_id:
pmid:
- '7889569'
intvolume: ' 80'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/0092867495903542
month: '02'
oa: 1
oa_version: Published Version
page: 757 - 765
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '4339'
quality_controlled: '1'
status: public
title: Specific deficit of the ON response in visual transmission by targeted disruption
of the mGIuR6 gene
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 80
year: '1995'
...