---
_id: '4186'
abstract:
- lang: eng
text: 'Neural crest development involves cell-fate specification, proliferation,
patterned cell migration, survival and differentiation, Zebrafish neural crest
derivatives include three distinct chromatophores, which are well-suited to genetic
analysis of their development, As part of a large-scale mutagenesis screen for
embryonic/early larval mutations, we have isolated 285 mutations affecting all
aspects of zebrafish larval pigmentation, By complementation analysis, we define
94 genes, We show here that comparison of their phenotypes permits classification
of these mutations according to the types of defects they cause, and these suggest
which process of neural crest development is probably affected, Mutations in eight
genes affect the number of chromatophores: these include strong candidates for
genes necessary for the processes of pigment cell specification and proliferation,
Mutations in five genes remove part of the wild-type pigment pattern, and suggest
a role in larval pigment pattern formation, Mutations in five genes show ectopic
chromatophores in distinct sites, and may have implications for chromatophore
patterning and proliferation, 76 genes affect pigment or morphology of one or
more chromatophore types: these mutations include strong candidates for genes
important in various aspects of chromatophore differentiation and survival, In
combination with the embryological advantages of zebrafish, these mutations should
permit cellular and molecular dissection of many aspects of neural crest development.'
acknowledgement: We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and
Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral
Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Lisa
full_name: Vogelsang, Lisa
last_name: Vogelsang
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the
processes of neural crest development. Development. 1996;123(1):369-389.
doi:10.1242/dev.123.1.369
apa: Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P.,
… Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes
of neural crest development. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.369
chicago: Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg,
Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations
and the Processes of Neural Crest Development.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.369.
ieee: R. Kelsh et al., “Zebrafish pigmentation mutations and the processes
of neural crest development,” Development, vol. 123, no. 1. Company of
Biologists, pp. 369–389, 1996.
ista: Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J,
Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D,
Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation
mutations and the processes of neural crest development. Development. 123(1),
369–389.
mla: Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of
Neural Crest Development.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 369–89, doi:10.1242/dev.123.1.369.
short: R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J.
Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development
123 (1996) 369–389.
date_created: 2018-12-11T12:07:28Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T11:16:49Z
day: '01'
doi: 10.1242/dev.123.1.369
extern: '1'
external_id:
pmid:
- '9007256 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 369 - 389
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1933'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zebrafish pigmentation mutations and the processes of neural crest development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4188'
abstract:
- lang: eng
text: 'Epiboly, the enveloping of the yolk cell by the blastoderm, is the first
zebrafish morphogenetic movement, We isolated four mutations that affect epiboly:
half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal
progress of the deep cells of the blastoderm; only the yolk syncytial layer of
the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole
of the embryo, The mutations half baked, avalanche and lawine produce a novel
dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos
produced from heterozygous females slow down epiboly and accumulate detached cells
over the neural tube; a small fraction of these mutant individuals are viable,
Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type
females complete epiboly normally and are completely viable. Additionally, embryos
heterozygous for half baked have an enlarged hatching gland, a partial dominant
phenotype, The phenotypes of these mutants demonstrate that, for the spreading
of cells during epiboly, the movement of the deep cells of the blastoderm require
the function of genes that are not necessary for the movement of the enveloping
layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes
illustrate the maternal and zygotic interplay of genes that orchestrate the early
cell movements of the zebrafish.'
acknowledgement: We thank Drs John Postlethwait and Sigfreid Roth for their helpful
comments on earlier drafts of this paper. This work was supported in part by a grant
from the National Institutes of Health to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. Development.
1996;123(1):47-55. doi:10.1242/dev.123.1.47
apa: Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.47
chicago: Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.47 .
ieee: D. Kane et al., “The zebrafish epiboly mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.
ista: Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development.
123(1), 47–55.
mla: Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:10.1242/dev.123.1.47 .
short: D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:22:40Z
day: '01'
doi: '10.1242/dev.123.1.47 '
extern: '1'
external_id:
pmid:
- '9007228 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 47 - 55
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1930'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish epiboly mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4189'
abstract:
- lang: eng
text: 'This report describes mutants of the zebrafish having phenotypes causing
a general arrest in early morphogenesis. These mutants identify a group of loci
making up about 20% of the loci identified by mutants with visible morphological
phenotypes within the first day of development. There are 12 Class I mutants,
which fall into 5 complementation groups and have cells that lyse before morphological
defects are observed. Mutants at three loci, speed bump, ogre and zombie, display
abnormal nuclei. The 8 Class II mutants, which fall into 6 complementation groups,
arrest development before cell lysis is observed. These mutants seemingly stop
development in the late segmentation stages, and maintain a body shape similar
to a 20 hour embryo. Mutations in speed bump, ogre, zombie, specter, poltergeist
and troll were tested for cell lethality by transplanting mutant cells into wild-type
hosts. With poltergeist, transplanted mutant cells all survive. The remainder
of the mutants tested were autonomously but conditionally lethal: mutant cells,
most of which lyse, sometimes survive to become notochord, muscles, or, in rare
cases, large neurons, all cell types which become postmitotic in the gastrula.
Some of the genes of the early arrest group may be necessary for progression though
the cell cycle; if so, the survival of early differentiating cells may be based
on having their terminal mitosis before the zygotic requirement for these genes.'
acknowledgement: We thank Dr Adam Felsenfeld for his careful comments on earlier drafts
of this manuscript, D. A. K. also thanks the two anonymous referees who patiently
pointed out a number of ‘speed bumps’ in the first submitted draft of this manuscript.
This work was supported in part by a grant from the National Institutes of Health
to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Maischein H, Brand M, et al. The zebrafish early arrest mutants. Development.
1996;123(1):57-66. doi:10.1242/dev.123.1.57
apa: Kane, D., Maischein, H., Brand, M., Van Eeden, F., Furutani Seiki, M., Granato,
M., … Nüsslein Volhard, C. (1996). The zebrafish early arrest mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.57
chicago: Kane, Donald, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto
Furutani Seiki, Michael Granato, Pascal Haffter, et al. “The Zebrafish Early Arrest
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.57 .
ieee: D. Kane et al., “The zebrafish early arrest mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 57–66, 1996.
ista: Kane D, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kelsh R, Mullins M, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish early arrest mutants. Development.
123(1), 57–66.
mla: Kane, Donald, et al. “The Zebrafish Early Arrest Mutants.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 57–66, doi:10.1242/dev.123.1.57 .
short: D. Kane, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 57–66.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:43:44Z
day: '01'
doi: '10.1242/dev.123.1.57 '
extern: '1'
external_id:
pmid:
- '9007229 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 57 - 66
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish early arrest mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4191'
abstract:
- lang: eng
text: In a screen for embryonic mutants in the zebrafish a large number of mutants
were isolated with abnormal brain morphology, We describe here 26 mutants in 13
complementation groups that show abnormal development of large regions of the
brain, Early neurogenesis is affected in white tail (wit), During segmentation
stages, homozygous wit embryos display an irregularly formed neural keel, particularly
in the hindbrain, Using a variety of molecular markers, a severe increase in the
number of various early differentiating neurons can be demonstrated, In contrast,
late differentiating neurons, radial glial cells and some nonneural cell types,
such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis
appears delayed, In addition, very reduced numbers of melanophores are present
posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants
in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general
organization of the hindbrain is disturbed and many rounded cells accumulate loosely
in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk),
natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop
collapsed brain ventricles, before showing signs of general degeneration, atlantis
(atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele)
mutants have different malformation of the brain folds, Some of them have transient
phenotypes, and mutant individuals may grow up to adults.
acknowledgement: We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield,
Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse
Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan
and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants
to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J.
J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).
article_processing_charge: No
article_type: original
author:
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis
and brain morphology in the zebrafish, Danio rerio. Development. 1996;123(1):205-216.
doi:10.1242/dev.123.1.205
apa: Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M.,
Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and
brain morphology in the zebrafish, Danio rerio. Development. Company of
Biologists. https://doi.org/10.1242/dev.123.1.205
chicago: Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle,
Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting
Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.205.
ieee: Y. Jiang et al., “Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 205–216, 1996.
ista: Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga
R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio. Development. 123(1), 205–216.
mla: Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 205–16, doi:10.1242/dev.123.1.205.
short: Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R.
Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins,
J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.
date_created: 2018-12-11T12:07:30Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:13:51Z
day: '01'
doi: 10.1242/dev.123.1.205
extern: '1'
external_id:
pmid:
- '9007241'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 205 - 216
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4203'
abstract:
- lang: eng
text: 'We identified four zebrafish mutants with defects in forebrain induction
and patterning during embryogenesis. The four mutants define three genes: masterblind
(mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain
acquires posterior forebrain characteristics: anterior structures such as the
eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis
located in the posterior forebrain is expanded, In slb embryos, the extension
of the embryonic axis is initially delayed and eventually followed by a partial
fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia
is incomplete and dorsal midline cells fail to form a differentiated roof plate,
Analysis of the mutant phenotypes indicates that we have identified genes essential
for the specification of the anterior forebrain (mbl), positioning of the eyes
(slb) and differentiation of the roof plate (kas). In an appendix to this study
we list mutants showing alterations in the size of the eyes and abnormal differentiation
of the lenses.'
acknowledgement: We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b
cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and
V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for
help with the initial characterization of the mbl phenotype and many valuable comments
on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan,
Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of
the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development
in the zebrafish, Danio rerio. Development. 1996;123:191-203. doi:10.1242/dev.123.1.191
apa: Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in
the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.191
chicago: Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga,
Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved
in Forebrain Development in the Zebrafish, Danio Rerio.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.191
.
ieee: C.-P. J. Heisenberg et al., “Genes involved in forebrain development
in the zebrafish, Danio rerio,” Development, vol. 123. Company of Biologists,
pp. 191–203, 1996.
ista: Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish,
Danio rerio. Development. 123, 191–203.
mla: Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development
in the Zebrafish, Danio Rerio.” Development, vol. 123, Company of Biologists,
1996, pp. 191–203, doi:10.1242/dev.123.1.191
.
short: C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.
date_created: 2018-12-11T12:07:34Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T08:06:15Z
day: '01'
doi: '10.1242/dev.123.1.191 '
extern: '1'
external_id:
pmid:
- '9007240 '
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 191 - 203
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes involved in forebrain development in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4208'
abstract:
- lang: eng
text: 'We have identified several genes that are required for various morphogenetic
processes during gastrulation and tail formation, Two genes are required in the
anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns).
oep mutant embryos are defective in prechordal plate formation and the specification
of anterior and ventral structures of the central nervous system, In dns mutants,
cells of the prechordal plate, such as the prospective hatching gland cells, fail
to specify. Two genes are required for convergence and extension movements. In
mutant trilobite embryos, extension movements on the dorsal side of the embryo
are affected, whereas in the formerly described spadetail mutants, for which two
new alleles have been isolated, convergent movements of ventrolateral cells to
the dorsal side are blocked. Two genes are required for the development of the
posterior end of the body axis, In pipetail mutants, the tailbud fails to move
ventrally on the yolk sac after germ ring closure, and the tip of the tail fails
to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube
at the posterior side of the yolk sac.'
acknowledgement: M. H. and F. P. contributed equally to this work. We are very grateful
to Dr Andrew McMahon, in whose laboratory much of the mutant analysis has been carried
out. Additionally, we would like to thank Ed Sullivan for his help and advice during
the setting-up of a fish facility in the McMahon laboratory. Dr Eric Weinberg generously
supplied us with the myoD cDNA prior to publication. Published reagents were obtained
from Drs Marie-Andrée Akimenko, Jean Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Mutations affecting morphogenesis
during gastrulation and tail formation in the zebrafish, Danio rerio. Development.
1996;123(1):143-151. doi:10.1242/dev.123.1.143
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.143
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations
Affecting Morphogenesis during Gastrulation and Tail Formation in the Zebrafish,
Danio Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.143.
ieee: M. Hammerschmidt et al., “Mutations affecting morphogenesis during
gastrulation and tail formation in the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 143–151, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. 123(1), 143–151.
mla: Hammerschmidt, Matthias, et al. “Mutations Affecting Morphogenesis during Gastrulation
and Tail Formation in the Zebrafish, Danio Rerio.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 143–51, doi:10.1242/dev.123.1.143.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 143–151.
date_created: 2018-12-11T12:07:35Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T06:59:42Z
day: '01'
doi: 10.1242/dev.123.1.143
extern: '1'
external_id:
pmid:
- '9007236'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 143 - 151
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1908'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting morphogenesis during gastrulation and tail formation in
the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4210'
abstract:
- lang: eng
text: Mutations causing a visible phenotype in the adult serve as valuable visible
genetic markers in multicellular genetic model organisms such as Drosophila melanogaster,
Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations
affecting early development of the zebrafish, we identified a number of mutations
that are homozygous viable or semiviable. Here we describe viable mutations which
produce visible phenotypes in the adult fish. These predominantly affect the fins
and pigmentation, but also the eyes and body length of the adult. A number of
dominant mutations caused visible phenotypes in the adult fish, Mutations in three
genes, long fin, another long fin and wanda affected fin formation in the adult.
Four mutations were found to cause a dominant reduction of the overall body length
in the adult. The adult pigment pattern was found to be changed by dominant mutations
in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations
producing visible phenotypes in the homozygous adult, a group of mutations that
failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy
produced embryos that failed to express tyrosinase activity. These are potentially
useful for using tyrosinase as a marker for the generation of transgenic lines
of zebrafish.
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Michael
full_name: Farrell, Michael
last_name: Farrell
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Fabian
full_name: Haas, Fabian
last_name: Haas
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Nancy
full_name: Hopkins, Nancy
last_name: Hopkins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Odenthal J, Mullins M, et al. Mutations affecting pigmentation and
shape of the adult zebrafish. Development Genes and Evolution. 1996;206(4):260-276.
doi:10.1007/s004270050051
apa: Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E.,
… Nüsslein Volhard, C. (1996). Mutations affecting pigmentation and shape of the
adult zebrafish. Development Genes and Evolution. Springer. https://doi.org/10.1007/s004270050051
chicago: Haffter, Pascal, Jörg Odenthal, Mary Mullins, Shuo Lin, Michael Farrell,
Elisabeth Vogelsang, Fabian Haas, et al. “Mutations Affecting Pigmentation and
Shape of the Adult Zebrafish.” Development Genes and Evolution. Springer,
1996. https://doi.org/10.1007/s004270050051.
ieee: P. Haffter et al., “Mutations affecting pigmentation and shape of the
adult zebrafish,” Development Genes and Evolution, vol. 206, no. 4. Springer,
pp. 260–276, 1996.
ista: Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, Haas F, Brand
M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ,
Jiang Y, Kane D, Kelsh R, Hopkins N, Nüsslein Volhard C. 1996. Mutations affecting
pigmentation and shape of the adult zebrafish. Development Genes and Evolution.
206(4), 260–276.
mla: Haffter, Pascal, et al. “Mutations Affecting Pigmentation and Shape of the
Adult Zebrafish.” Development Genes and Evolution, vol. 206, no. 4, Springer,
1996, pp. 260–76, doi:10.1007/s004270050051.
short: P. Haffter, J. Odenthal, M. Mullins, S. Lin, M. Farrell, E. Vogelsang, F.
Haas, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, N. Hopkins, C. Nüsslein Volhard,
Development Genes and Evolution 206 (1996) 260–276.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-11-27T00:00:00Z
date_updated: 2022-08-04T14:45:21Z
day: '27'
doi: 10.1007/s004270050051
extern: '1'
external_id:
pmid:
- '24173565'
intvolume: ' 206'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 260 - 276
pmid: 1
publication: Development Genes and Evolution
publication_identifier:
issn:
- 0043-5546
publication_status: published
publisher: Springer
publist_id: '1906'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting pigmentation and shape of the adult zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 206
year: '1996'
...
---
_id: '4211'
abstract:
- lang: eng
text: We describe two genes, dino and mercedes, which are required for the organization
of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the
expense of the head and the anterior region of the trunk, The altered expression
patterns of various marker genes reveal that, with the exception of the dorsal
most marginal zone, all regions of the early dine mutant embryo acquire more ventral
fates, These alterations are already apparent before the onset of gastrulation,
mercedes mutant embryos show a similar but weaker phenotype, suggesting a role
in the same patterning processes. The phenotypes suggests that dine and mercedes
are required for the establishment of dorsal fates in both the marginal and the
animal zone of the early gastrula embryo, Their function in the patterning of
the ventrolateral mesoderm and the induction of the neuroectoderm is similar to
the function of the Spemann organizer in the amphibian embryo.
acknowledgement: "We are very grateful to Dr Andrew McMahon in whose laboratory much
of the mutant analysis has been carried out. Additionally, we would like to thank
Ed Sullivan for his help and advice during the setting up of a fish facility in
the McMahon laboratory. Drs Eric Weinberg and Leonard Zon generously supplied us
with reagents prior to publication. Published reagents were obtained from Drs Jon
Graff, Jean-Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.\r\nDrs Mary
Dickinson, Andrew McMahon, Siegfried Roth and Stefan Schulte-Merker read earlier
versions of the Manuscript. "
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Dino and Mercedes, two genes
regulating dorsal development in the zebrafish embryo. Development. 1996;123(1):95-102.
doi:10.1242/dev.123.1.95
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato,
M., … Nüsslein Volhard, C. (1996). Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.95
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes,
Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.95.
ieee: M. Hammerschmidt et al., “Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo,” Development, vol. 123, no. 1. Company
of Biologists, pp. 95–102, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand
M, Furutani Seiki M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. 123(1), 95–102.
mla: Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal
Development in the Zebrafish Embryo.” Development, vol. 123, no. 1, Company
of Biologists, 1996, pp. 95–102, doi:10.1242/dev.123.1.95.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato,
M. Brand, M. Furutani Seiki, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T15:10:34Z
day: '01'
doi: 10.1242/dev.123.1.95
extern: '1'
external_id:
pmid:
- '9007232'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 95 - 102
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dino and Mercedes, two genes regulating dorsal development in the zebrafish
embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4212'
abstract:
- lang: eng
text: In a large-scale screen, we isolated mutants displaying a specific visible
phenotype in embryos or early larvae of the zebrafish, Danio rerio. Males were
mutagenized with ethylnitrosourea (ENU) and F-2 families of single pair matings
between sibling F-l fish, heterozygous for a mutagenized genome, were raised.
Egg lays were obtained from several crosses between F-2 siblings, resulting in
scoring of 3857 mutagenized genomes. F-3 progeny were scored at the second, third
and sixth day of development, using a stereomicroscope. In a subsequent screen,
fixed embryos were analyzed for correct retinotectal projection. A total of 4264
mutants were identified. Two thirds of the mutants displaying rather general abnormalities
were eventually discarded. We kept and characterized 1163 mutants. In complementation
crosses performed between mutants with similar phenotypes, 894 mutants have been
assigned to 372 genes. The average allele frequency is 2.4. We identified genes
involved in early development, notochord, brain, spinal cord, somites, muscles,
heart, circulation, blood, skin, fin, eye, otic vesicle, jaw and branchial arches,
pigment pattern, pigment formation, gut, liver, motility and touch response. Our
collection contains alleles of almost all previously described zebrafish mutants.
From the allele frequencies and other considerations we estimate that the 372
genes defined by the mutants probably represent more than half of all genes that
could have been discovered using the criteria of our screen. Here we give an overview
of the spectrum of mutant phenotypes obtained, and discuss the limits and the
potentials of a genetic saturation screen in the zebrafish.
acknowledgement: "This work was a collaborative effort in which a large number of
people participated during all or part of the three years of raising the families,
screening and evaluation of the mutants. We thank Rachel Warga, Tatjana Piotrowski,
Francisco Pelegri, Karin Rossnagel and Hans-Martin Maischein for collaboration at
the beginning and the end of the screening and evaluation periods respectively;
Hans-Georg Frohnhöfer for fish health care and for establishing the Tübingen zebrafish
stockcenter; and Wolfgang Driever, Marc Fishman and collaborators, for sharing unpublished
results. We enjoyed the visits of Alison Brownlie, Jau-Nian Chen, Nancy Hopkins,
Corinne Houart, Shuo Lin, David Ransom, Thomas Schilling, Tanya Whitfield and Catherine
Willet, who participated in the analysis of individual mutant classes. We also want
to thank many undergraduate students from the Tübingen University for conscientious
and efficient help in the maintenance and identification of fish, and Torsten Trowe,
Rolf Karlstrom, Barbara Grunwald and Friedrich Bonhoeffer for pleasant and interesting
conversations and collaborations. We thank the staff of our workshop for patience,
\r\n Inventiveness and a very large number of fish containers. We thank Herwig Baier,
Robert Geisler, Darren Gilmour,\r\nNancy Hopkins, Suresh Jesuthasan, Gerd Jürgens,
Francisco Pelegri, Siegfried Roth, Stefan Schulte-Merker, Ralf Sommer, Daniel St
Johnston and Tanya Whitfield, for many helpful suggestions on the manuscript; Robert
Geisler for invaluable help with computers, cameras and colour printers, and the
Tübingen fly group for interest, endless patience and support."
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Cosima
full_name: Fabian, Cosima
last_name: Fabian
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Granato M, Brand M, et al. The identification of genes with unique
and essential functions in the development of the zebrafish, Danio rerio. Development.
1996;123(1):1-36. doi:10.1242/dev.123.1.1
apa: Haffter, P., Granato, M., Brand, M., Mullins, M., Hammerschmidt, M., Kane,
D., … Nüsslein Volhard, C. (1996). The identification of genes with unique and
essential functions in the development of the zebrafish, Danio rerio. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.1
chicago: Haffter, Pascal, Michael Granato, Michael Brand, Mary Mullins, Matthias
Hammerschmidt, Donald Kane, Jörg Odenthal, et al. “The Identification of Genes
with Unique and Essential Functions in the Development of the Zebrafish, Danio
Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.1 .
ieee: P. Haffter et al., “The identification of genes with unique and essential
functions in the development of the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 1–36, 1996.
ista: Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, Odenthal
J, Van Eeden F, Jiang Y, Heisenberg C-PJ, Kelsh R, Furutani Seiki M, Vogelsang
E, Beuchle D, Schach U, Fabian C, Nüsslein Volhard C. 1996. The identification
of genes with unique and essential functions in the development of the zebrafish,
Danio rerio. Development. 123(1), 1–36.
mla: Haffter, Pascal, et al. “The Identification of Genes with Unique and Essential
Functions in the Development of the Zebrafish, Danio Rerio.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 1–36, doi:10.1242/dev.123.1.1 .
short: P. Haffter, M. Granato, M. Brand, M. Mullins, M. Hammerschmidt, D. Kane,
J. Odenthal, F. Van Eeden, Y. Jiang, C.-P.J. Heisenberg, R. Kelsh, M. Furutani
Seiki, E. Vogelsang, D. Beuchle, U. Schach, C. Fabian, C. Nüsslein Volhard, Development
123 (1996) 1–36.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:41:37Z
day: '01'
doi: '10.1242/dev.123.1.1 '
extern: '1'
external_id:
pmid:
- '9007226 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 1 - 36
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The identification of genes with unique and essential functions in the development
of the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4213'
abstract:
- lang: eng
text: 'Forty zebrafish mutants with localized or general neural degeneration are
described. The onset and duration of degeneration and the distribution of ectopically
dying cells are specific characteristics of each mutant, Mutants are classified
into four groups by these parameters. Class I: late focal neural degeneration
mutants, These 18 mutants have restricted cell death mainly in the tectum and
the dorsal hindbrain after 36 hours, The degeneration does not spread and disappears
at later stages of development. Class LI: early focal neural degeneration mutants.
Ten mutants in this class exhibit transient restricted degeneration affecting
mainly the diencephalon, the hindbrain and the spinal cord at 20 hours, The midbrain
is less affected. The degeneration shifts to the dorsal diencephalon and the tectum
at 36 hours. Class III: late spreading neural degeneration mutants. The 8 mutants
in this class display a degeneration that is first seen in the tectum and subsequently
spreads throughout the nervous system from 36 hours on. Class IV: early general
neural degeneration mutants, This class of four mutants already shows overall
cell degeneration in the nervous system at the 15-somite stage. Three of the class
I mutants show a change in the pattern of gene expression in the anlage of a brain
structure prior to the onset of degeneration. These results suggest that focal
cell death may be a useful clue for the detection of early patterning defects
of the vertebrate nervous system in regions devoid of visible landmarks.'
acknowledgement: We are grateful to Rachel Warga, Tatijana Piotrowski, Francisco Pelegri
and Tomas Schilling for sharing unpublished results. We thank Heinz Schwarz for
histological sections and Eric Weinberg, Monte Westerfield, Stephen Wilson and Hitoshi
Okamoto for in situprobes. We also thank Nancy Hopkins, Francisco Pelegri and Stefan
Schulte-Merker for helpful suggestions on the manuscript, and Raymond Lamos for
technical support.
article_processing_charge: No
article_type: original
author:
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Corinne
full_name: Houart, Corinne
last_name: Houart
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Furutani Seiki M, Jiang Y, Brand M, et al. Neural degeneration mutants in the
zebrafish, Danio rerio. Development. 1996;123(1):229-239. doi:10.1242/dev.123.1.229
apa: Furutani Seiki, M., Jiang, Y., Brand, M., Heisenberg, C.-P. J., Houart, C.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Neural degeneration mutants in the
zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.229
chicago: Furutani Seiki, Makoto, Yunjin Jiang, Michael Brand, Carl-Philipp J Heisenberg,
Corinne Houart, Dirk Beuchle, Fredericus Van Eeden, et al. “Neural Degeneration
Mutants in the Zebrafish, Danio Rerio.” Development. Company of Biologists,
1996. https://doi.org/10.1242/dev.123.1.229
.
ieee: M. Furutani Seiki et al., “Neural degeneration mutants in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
229–239, 1996.
ista: Furutani Seiki M, Jiang Y, Brand M, Heisenberg C-PJ, Houart C, Beuchle D,
Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M,
Odenthal J, Nüsslein Volhard C. 1996. Neural degeneration mutants in the zebrafish,
Danio rerio. Development. 123(1), 229–239.
mla: Furutani Seiki, Makoto, et al. “Neural Degeneration Mutants in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 229–39, doi:10.1242/dev.123.1.229
.
short: M. Furutani Seiki, Y. Jiang, M. Brand, C.-P.J. Heisenberg, C. Houart, D.
Beuchle, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 229–239.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:02:39Z
day: '01'
doi: '10.1242/dev.123.1.229 '
extern: '1'
external_id:
pmid:
- '9007243 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 229 - 239
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1903'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neural degeneration mutants in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4214'
abstract:
- lang: eng
text: 'Zebrafish embryos and larvae have stage-specific patterns of motility or
locomotion, Two embryonic structures accomplish this behavior: the central nervous
system (CNS) and skeletal muscles. To identify genes that are functionally involved
in mediating and controlling different patterns of embryonic and larval motility,
we included a simple touch response test in our zebrafish large-scale genetic
screen, In total we identified 166 mutants with specific defects in embryonic
motility. These mutants fall into 14 phenotypically distinct groups comprising
at least 48 genes, Here we describe the various phenotypic groups including mutants
with no or reduced motility, mechanosensory defective mutants, ''spastic'' mutants,
circling mutants and motor circuit defective mutants, In 63 mutants, defining
18 genes, striation of semitic muscles is reduced, Phenotypic analysis provides
evidence that these 18 genes have distinct and consecutive functions during semitic
muscle development. The genes sloth (slo) and frozen (fro) already act during
myoblast differentiation, while 13 genes appear to function later, in the formation
of myofibers and the organization of sarcomeres, Mutations in four other genes
result in muscle-specific degeneration, 103 mutations, defining at least 30 genes,
cause no obvious defects in muscle formation and may instead affect neuronal development.
Analysis of the behavioral defects suggests that these genes participate in the
diverse locomotion patterns observed, such as touch response, rhythmic tail movements,
equilibrium control, or that they simply confer general motility to the animal,
In some of these mutants specific defects in the developing nervous system are
detected, Mutations in two genes, nevermind (nev) and macho (mao), affect axonal
projection in the optic tectum, whereas axon formation and elongation of motorneurons
are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes.'
acknowledgement: We would like to thank C. Kimmel, J. Eisen and M. Westerfield for
providing the nic and fub mutant strains used for complementation and for the znp1
antibody. In addition we thank Tanja Whitfield and Suresh Jesuthesan for critical
reading of the manuscript. This work was supported by a DFG postdoctoral fellowship
Gr 1370/1-1 to M.G.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Granato M, Van Eeden F, Schach U, et al. Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. 1996;123:399-413.
doi:10.1242/dev.123.1.399
apa: Granato, M., Van Eeden, F., Schach, U., Trowe, T., Brand, M., Furutani Seiki,
M., … Nüsslein Volhard, C. (1996). Genes controlling and mediating locomotion
behavior of the zebrafish embryo and larva. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.399
chicago: Granato, Michael, Fredericus Van Eeden, Ursula Schach, Torsten Trowe, Michael
Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Genes Controlling and Mediating
Locomotion Behavior of the Zebrafish Embryo and Larva.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.399.
ieee: M. Granato et al., “Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva,” Development, vol. 123. Company of Biologists,
pp. 399–413, 1996.
ista: Granato M, Van Eeden F, Schach U, Trowe T, Brand M, Furutani Seiki M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes controlling and mediating locomotion behavior
of the zebrafish embryo and larva. Development. 123, 399–413.
mla: Granato, Michael, et al. “Genes Controlling and Mediating Locomotion Behavior
of the Zebrafish Embryo and Larva.” Development, vol. 123, Company of Biologists,
1996, pp. 399–413, doi:10.1242/dev.123.1.399.
short: M. Granato, F. Van Eeden, U. Schach, T. Trowe, M. Brand, M. Furutani Seiki,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 399–413.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:20:50Z
day: '01'
doi: 10.1242/dev.123.1.399
extern: '1'
external_id:
pmid:
- '9007258'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 399 - 413
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes controlling and mediating locomotion behavior of the zebrafish embryo
and larva
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4215'
abstract:
- lang: eng
text: In a screen for early developmental mutants of the zebrafish, we have identified
mutations specifically affecting the internal organs, We identified 53 mutations
affecting the cardiovascular system, Nine of them affect specific landmarks of
heart morphogenesis. Mutations in four genes cause a failure in the fusion of
the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no
heart venticle is visible and the atrium is directly fused to the outflow tract.
In the overlooped mutant, the relative position of the two heart chambers is distorted,
The heart is enormously enlarged in the santa mutant, In two mutants, scotch tape
and superglue, the cardiac jelly between the two layers of the heart is significantly
reduced, We also identified a number of mutations affecting the function of the
heart, The mutations affecting heart function can be subdivided into two groups,
one affecting heart contraction and another affecting the rhythm of the heart
beat. Among the contractility group of mutants are 5 with no heart beat at all
and 15 with a reduced heart beat of one or both chambers, 6 mutations are in the
rhythmicity group and specifically affect the beating pattern of the heart, Mutations
in two genes, bypass and kurzschluss, cause specific defects in the circulatory
system, In addition to the heart mutants, we identified 23 mutations affecting
the integrity of the liver, the intestine or the kidney, In this report, we demonstrate
that it is feasible to screen for genes specific for the patterning or function
of certain internal organs in the zebrafish, The mutations presented here could
serve as an entrypoint to the establishment of a genetic hierarchy underlying
organogenesis.
acknowledgement: We thank Chris Simpson and Colleen Boggs for excellent technical
help. We thank Mark C. Fishman for the advice and providing fish for complementation;
Bernadette Fouquet, Kerri S. Warren and Brant M. Weinstein for critically reading
the manuscript. JNC is supported in part by NIH grant RO1-HL49579 to Mark C. Fishman.
article_processing_charge: No
article_type: original
author:
- first_name: Jaunian
full_name: Chen, Jaunian
last_name: Chen
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Chen J, Haffter P, Odenthal J, et al. Mutations affecting the cardiovascular
system and other internal organs in zebrafish. Development. 1996;123:293-302.
doi:10.1242/dev.123.1.293
apa: Chen, J., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Van Eeden, F.,
… Nüsslein Volhard, C. (1996). Mutations affecting the cardiovascular system and
other internal organs in zebrafish. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.293
chicago: Chen, Jaunian, Pascal Haffter, Jörg Odenthal, Elisabeth Vogelsang, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting
the Cardiovascular System and Other Internal Organs in Zebrafish.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.293.
ieee: J. Chen et al., “Mutations affecting the cardiovascular system and
other internal organs in zebrafish,” Development, vol. 123. Company of
Biologists, pp. 293–302, 1996.
ista: Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R,
Mullins M, Nüsslein Volhard C. 1996. Mutations affecting the cardiovascular system
and other internal organs in zebrafish. Development. 123, 293–302.
mla: Chen, Jaunian, et al. “Mutations Affecting the Cardiovascular System and Other
Internal Organs in Zebrafish.” Development, vol. 123, Company of Biologists,
1996, pp. 293–302, doi:10.1242/dev.123.1.293.
short: J. Chen, P. Haffter, J. Odenthal, E. Vogelsang, M. Brand, F. Van Eeden, M.
Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D.
Kane, R. Kelsh, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 293–302.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T13:11:56Z
day: '01'
doi: 10.1242/dev.123.1.293
extern: '1'
external_id:
pmid:
- '9007249'
intvolume: ' 123'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/293/39344/Mutations-affecting-the-cardiovascular-system-and
month: '12'
oa: 1
oa_version: Published Version
page: 293 - 302
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1902'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting the cardiovascular system and other internal organs in
zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4216'
abstract:
- lang: eng
text: Tissues of the dorsal midline of vertebrate embryos, such as notochord and
floor plate, have been implicated in inductive interactions that pattern the neural
tube and somites. In our screen for embryonic visible mutations in the zebrafish
we found 113 mutations in more than 27 genes with altered body shape, often with
additional defects in CNS development. We concentrated on a subgroup of mutations
in ten genes (the midline-group) that cause defective development of the floor
plate. By using floor plate markers, such as the signaling molecule sonic hedgehog,
we show that the schmalspur (sur) gene is needed for early floor plate development,
similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene.
In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted
to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In
the underlying mesendodermal tissue of the head, sur is needed only for development
of the posterior prechordal plate, whereas oep and eye are required for both anterior
and posterior prechordal plate development. Our analysis of sur mutants suggests
that defects within the posterior prechordal plate may cause aberrant development
of ventral CNS structures in the mid- and hindbrain. Later development of the
floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour,
schmalkars and monorail embryos; these mutants often show additional defects in
tissues that are known to depend on signals from notochord and floor plate, For
example, sur, con, and yot mutants show reduction of motor neurons; median deletions
of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and
dtr mutants often show no or abnormal formation of the optic chiasm. We also find
fusions of the ventral neurocranium for all midline mutants tested, which may
reveal a hitherto unrecognized function of the midline in influencing differentiation
of neural crest cells at their destination. As a working hypothesis, we propose
that midline-group genes may act to maintain proper structure and inductive function
of zebrafish midline tissues.
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss
and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg
and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript,
his colleagues at the institute for numerous discussions, Inge Zimmermann for patient
sectioning, and Silke Hein for help during the final\r\nstages of this work. M.
B. was supported by a Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Rolf
full_name: Karlstrom, Rolf
last_name: Karlstrom
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Alexander
full_name: Picker, Alexander
last_name: Picker
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of
the midline and general body shape during zebrafish embryogenesis. Development.
1996;123(1):129-142. doi:10.1242/dev.123.1.129
apa: Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle,
D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline
and general body shape during zebrafish embryogenesis. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.129
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri,
Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development
of the Midline and General Body Shape during Zebrafish Embryogenesis.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.129
.
ieee: M. Brand et al., “Mutations affecting development of the midline and
general body shape during zebrafish embryogenesis,” Development, vol. 123,
no. 1. Company of Biologists, pp. 129–142, 1996.
ista: Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker
A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations
affecting development of the midline and general body shape during zebrafish embryogenesis.
Development. 123(1), 129–142.
mla: Brand, Michael, et al. “Mutations Affecting Development of the Midline and
General Body Shape during Zebrafish Embryogenesis.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 129–42, doi:10.1242/dev.123.1.129 .
short: M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle,
A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter,
M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard,
Development 123 (1996) 129–142.
date_created: 2018-12-11T12:07:38Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T12:55:13Z
day: '01'
doi: '10.1242/dev.123.1.129 '
extern: '1'
external_id:
pmid:
- '9007235 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and
month: '12'
oa: 1
oa_version: Published Version
page: 129 - 142
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1900'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the midline and general body shape during
zebrafish embryogenesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4219'
abstract:
- lang: eng
text: 'Mutations in two genes affect the formation of the boundary between midbrain
and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos
lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric
duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that
the MHB region and the dorsal and ventral midbrain are absent or abnormal, but
that the rostral hindbrain is unaffected with the exception of the cerebellum,
Using markers that are expressed during its formation (eng, wnt1 and pax-b), we
find that the MHB region is already misspecified in noi mutant embryos during
late gastrulation. The tectum is initially present and later degenerates, The
defect in ace mutant embryos is more restricted: MHB and cerebellum are absent,
but a tectum is formed, Molecular organisation of the tectum and tegmentum is
disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained,
We propose that noi and ace are required for development of the MHB region and
of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB
region, Presence of pax-b RNA, and absence of pax-b protein, together with the
observation of genetic linkage and the occurrence of a point mutation, show that
noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue
of the Drosophila gene paired, which is involved in a pathway of cellular interactions
at the posterior compartment boundary in Drosophila, Our results confirm and extend
a previous report, and show that at least one member of this conserved signalling
pathway is required for formation of the boundary between midbrain and hindbrain
in the zebrafish.'
acknowledgement: "We would like to thank our colleagues in the zebrafish community
for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir
Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder,
Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B
would like to thank his colleagues for numerous discussions, and Francisco Pelegri,
Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also
to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression,
and especially to Corinne Houart, for her lovely in situ protocol and many discussions.
Silke Hein helped greatly in final stages of this work. M.B. was supported by a
Helmholtz stipend of the BMFT."
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Klaus
full_name: Lun, Klaus
last_name: Lun
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
1996;123(1):179-190. doi:10.1242/dev.123.1.179
apa: Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting
the formation of the boundary between midbrain and hindbrain. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.179
chicago: Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle,
Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish
Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.”
Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.179 .
ieee: M. Brand et al., “Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain,” Development, vol. 123,
no. 1. Company of Biologists, pp. 179–190, 1996.
ista: Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato
M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation
of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.
mla: Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation
of the Boundary between Midbrain and Hindbrain.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 179–90, doi:10.1242/dev.123.1.179 .
short: M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki,
M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal,
F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T11:45:04Z
day: '01'
doi: '10.1242/dev.123.1.179 '
extern: '1'
external_id:
pmid:
- '9007239 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the
month: '12'
oa: 1
oa_version: Published Version
page: 179 - 190
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations in zebrafish genes affecting the formation of the boundary between
midbrain and hindbrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4220'
abstract:
- lang: eng
text: In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during
embryogenesis. At larval stages the caudal fin fold is replaced by four different
fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins
are formed, We have identified a total of 118 mutations affecting larval fin formation,
Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal
and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly
normal complement of adult fins, Mutations in nine genes result in an increased
or reduced size of the pectoral fins, Interestingly, in mutants of one of these
genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium
fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme
of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations
in five other genes affect adult fin but not larval fin development, Two mutants,
longfin (lof) and another longfin (alf) have generally longer fins. Stein und
bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda
(wan) mutants affect all adult fins, Finally, mutations in four genes causing
defects in embryonic skin formation will be briefly reported.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation
in the zebrafish, Danio rerio. Development. 1996;123(1):255-262. doi:10.1242/dev.123.1.255
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.255
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis
of Fin Formation in the Zebrafish, Danio Rerio.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.255
.
ieee: F. Van Eeden et al., “Genetic analysis of fin formation in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
255–262, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish,
Danio rerio. Development. 123(1), 255–262.
mla: Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 255–62, doi:10.1242/dev.123.1.255
.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262.
date_created: 2018-12-11T12:07:40Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T10:01:17Z
day: '01'
doi: '10.1242/dev.123.1.255 '
extern: '1'
external_id:
pmid:
- '9007245 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish
month: '12'
oa: 1
oa_version: Published Version
page: 255 - 262
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic analysis of fin formation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4222'
abstract:
- lang: eng
text: Somitogenesis is the basis of segmentation of the mesoderm in the trunk and
tail of vertebrate embryos, Two groups of mutants with defects in this patterning
process have been isolated in our screen for zygotic mutations affecting the embryonic
development of the zebrafish (Danio rerio), In mutants of the first group, boundaries
between individual somites are invisible early on, although the paraxial mesoderm
is present, Later, irregular boundaries between somites are present, Mutations
infused somites (fss) and beamter (bea) affect all somites, whereas mutations
in deadly seven (des), after eight (aei) and white tail (wit) only affect the
more posterior somites, Mutants of all genes but wit are homozygous viable and
fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest
that anteroposterior patterning within individual somites is abnormal, In the
second group of mutants, formation of the horizontal myoseptum, which separates
the dorsal and ventral part of the myotome, is reduced, Six genes have been defined
in this group (you-type genes), yea-too mutants show the most severe phenotype;
in these the adaxial cells, muscle pioneers and the primary motoneurons are affected,
in addition to the horizontal myoseptum. The horizontal myoseptum is also missing
in mutants that lack a notochord. The similarity of the somite phenotype in mutants
lacking the notochord and in the you-type mutants suggests that the genes mutated
in these two groups are involved in a signaling pathway from the notochord, important
for patterning of the somites.
acknowledgement: We would like to thank P. Ingham and T. Whitfield for valuable comments
on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J.
Eisen and R. BreMiller for the znp-1 antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 1996;123(1):153-164.
doi:10.1242/dev.123.1.153
apa: Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter,
P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.153
chicago: Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto
Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting
Somite Formation and Patterning in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.153.
ieee: F. Van Eeden et al., “Mutations affecting somite formation and patterning
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 153–164, 1996.
ista: Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt
M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R,
Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation
and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.
mla: Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 153–64, doi:10.1242/dev.123.1.153.
short: F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter,
M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 153–164.
date_created: 2018-12-11T12:07:41Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T09:29:56Z
day: '01'
doi: 10.1242/dev.123.1.153
extern: '1'
external_id:
pmid:
- '9007237 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and
month: '12'
oa: 1
oa_version: Published Version
page: 153 - 164
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1895'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting somite formation and patterning in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4292'
abstract:
- lang: eng
text: Ageing, or senescence, is a decline in state at later ages that is manifested
through a reduction in survival and fecundity. Ageing means that reproductive
prospects and hence the life history options (trade-offs) open to the organism
decline. Evolutionary theories of ageing suggest that it evolves in response to
the level of externally imposed mortality and insults to fertility, either as
part of life history optimization or as a result of mutation pressure. Several
recent empirical and theoretical studies have produced apparently anomalous results.
Some have suggested that the rate of ageing can decline at later ages, others
that demographic evidence for ageing can appear in parallel with an improvement
in state. All of these studies used measures of ageing that would not be expected
to give an accurate reflection of changes in the state of the organism with age.
We propose that Fisher's `reproductive value' is a natural measure of state at
each age, which includes prospects for both survival and reproduction. If this
measure is used, the apparently anomalous findings are not at variance with evolutionary
theories of ageing.
article_processing_charge: No
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Partridge L, Barton NH. On measuring the rate of ageing. Proceedings of
the Royal Society of London Series B Biological Sciences. 1996;263(1375):1365-1371.
doi:10.1098/rspb.1996.0200
apa: Partridge, L., & Barton, N. H. (1996). On measuring the rate of ageing.
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London. https://doi.org/10.1098/rspb.1996.0200
chicago: Partridge, Linda, and Nicholas H Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society of London, 1996. https://doi.org/10.1098/rspb.1996.0200.
ieee: L. Partridge and N. H. Barton, “On measuring the rate of ageing,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 263, no.
1375. Royal Society of London, pp. 1365–1371, 1996.
ista: Partridge L, Barton NH. 1996. On measuring the rate of ageing. Proceedings
of the Royal Society of London Series B Biological Sciences. 263(1375), 1365–1371.
mla: Partridge, Linda, and Nicholas H. Barton. “On Measuring the Rate of Ageing.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 263, no. 1375, Royal Society of London, 1996, pp. 1365–71, doi:10.1098/rspb.1996.0200.
short: L. Partridge, N.H. Barton, Proceedings of the Royal Society of London Series
B Biological Sciences 263 (1996) 1365–1371.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-10-22T00:00:00Z
date_updated: 2022-07-04T12:59:56Z
day: '22'
doi: 10.1098/rspb.1996.0200
extern: '1'
intvolume: ' 263'
issue: '1375'
language:
- iso: eng
main_file_link:
- url: https://royalsocietypublishing.org/doi/abs/10.1098/rspb.1996.0200
month: '10'
oa_version: None
page: 1365 - 1371
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0950-1193
publication_status: published
publisher: Royal Society of London
publist_id: '1786'
quality_controlled: '1'
status: public
title: On measuring the rate of ageing
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 263
year: '1996'
...
---
_id: '4294'
abstract:
- lang: eng
text: 'Any sample of genes traces back to a single common ancestor. Each gene also
has other properties: its sequence, its geographic location and the phenotype
and fitness of the organism that carries it. With sexual reproduction, different
genes have different genealogies, which gives us much more information, but also
greatly complicates population genetic analysis. We review the close relation
between the distribution of genealogies and the classic theory of identity by
descent in spatially structured populations, and develop a simple diffusion approximation
to the distribution of coalescence times in a homogeneous two-dimensional habitat.
This shows that when neighbourhood size is large (as in most populations) only
a small fraction of pairs of genes are closely related, and only this fraction
gives information about current rates of gene flow. The increase of spatial dispersion
with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy
depends on the long-term history of the population; we discuss ways of inferring
this history from the concordance between genealogies across loci.'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Ian
full_name: Wilson, Ian
last_name: Wilson
citation:
ama: 'Barton NH, Wilson I. Genealogies and geography. In: New Uses for New Phylogenies.
Oxford University Press; 1996:23-56. doi:10.1098/rstb.1995.0090'
apa: Barton, N. H., & Wilson, I. (1996). Genealogies and geography. In New
uses for new phylogenies (pp. 23–56). Oxford University Press. https://doi.org/10.1098/rstb.1995.0090
chicago: Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In New
Uses for New Phylogenies, 23–56. Oxford University Press, 1996. https://doi.org/10.1098/rstb.1995.0090.
ieee: N. H. Barton and I. Wilson, “Genealogies and geography,” in New uses for
new phylogenies, Oxford University Press, 1996, pp. 23–56.
ista: 'Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new
phylogenies. , 23–56.'
mla: Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” New Uses
for New Phylogenies, Oxford University Press, 1996, pp. 23–56, doi:10.1098/rstb.1995.0090.
short: N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University
Press, 1996, pp. 23–56.
date_created: 2018-12-11T12:08:05Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-04T08:59:18Z
day: '01'
doi: 10.1098/rstb.1995.0090
extern: '1'
external_id:
pmid:
- '8748019'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 56
pmid: 1
publication: New uses for new phylogenies
publication_identifier:
isbn:
- 978-0198549840
publication_status: published
publisher: Oxford University Press
publist_id: '1783'
quality_controlled: '1'
status: public
title: Genealogies and geography
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...
---
_id: '4295'
abstract:
- lang: eng
text: Genetic studies are beginning to provide insights into the evolutionary processes
that reduce the fitness of hybrids between recently diverged species. However,
the deleterious gene interactions responsible for this fitness reduction are still
poorly understood.
acknowledgement: Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael
Turelli for their comments on this note, and to the BBSRC and NERC for financial
support.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Speciation: more than the sum of its parts. In: Current Biology.
Vol 6. Cell Press; 1996:1244-1246. doi:10.1016/S0960-9822(02)70707-0'
apa: 'Barton, N. H. (1996). Speciation: more than the sum of its parts. In Current
Biology (Vol. 6, pp. 1244–1246). Cell Press. https://doi.org/10.1016/S0960-9822(02)70707-0'
chicago: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In Current
Biology, 6:1244–46. Cell Press, 1996. https://doi.org/10.1016/S0960-9822(02)70707-0.'
ieee: 'N. H. Barton, “Speciation: more than the sum of its parts,” in Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–1246.'
ista: 'Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology.
vol. 6, 1244–1246.'
mla: 'Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” Current
Biology, vol. 6, Cell Press, 1996, pp. 1244–46, doi:10.1016/S0960-9822(02)70707-0.'
short: N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.
date_created: 2018-12-11T12:08:06Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2022-07-07T09:28:28Z
day: '01'
doi: 10.1016/S0960-9822(02)70707-0
extern: '1'
external_id:
pmid:
- '8939554'
intvolume: ' 6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub
month: '10'
oa: 1
oa_version: Published Version
page: 1244 - 1246
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Speciation: more than the sum of its parts'
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1996'
...
---
_id: '4419'
abstract:
- lang: eng
text: A {\em hybrid automaton\/} consists of a finite automaton interacting with
a dynamical system. Hybrid automata are used to model embedded controllers and
other systems that consist of interacting discrete and continuous components.
A hybrid automaton is {\em rectangular\/} if each of its continuous variables~x
satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where
a and~b are rational constants. Rectangular hybrid automata are particularly useful
for the analysis of communication protocols in which local clocks have bounded
drift, and for the conservative approximation of systems with more complex continuous
behavior. We examine several verification problems on the class of rectangular
hybrid automata, including reachability, temporal logic model checking, and controller
synthesis. Both dense-time and discrete-time models are considered. We identify
subclasses of rectangular hybrid automata for which these problems are decidable
and give complexity analyses. An investigation of the structural properties of
rectangular hybrid automata is undertaken. One method for proving the decidability
of verification problems on infinite-state systems is to find finite quotient
systems on which analysis can proceed. Three state-space equivalence relations
with strong connections to temporal logic are bisimilarity, similarity, and language
equivalence. We characterize the quotient spaces of rectangular hybrid automata
with respect to these equivalence relations.
article_processing_charge: No
author:
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: Kopke P. The Theory of Rectangular Hybrid Automata. 1996.
apa: Kopke, P. (1996). The Theory of Rectangular Hybrid Automata. Cornell
University.
chicago: Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University,
1996.
ieee: P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University,
1996.
ista: Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.
mla: Kopke, Peter. The Theory of Rectangular Hybrid Automata. Cornell University,
1996.
short: P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University,
1996.
date_created: 2018-12-11T12:08:45Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-07-06T15:11:24Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication_status: published
publisher: Cornell University
publist_id: '312'
status: public
supervisor:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
title: The Theory of Rectangular Hybrid Automata
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1996'
...