---
_id: '4027'
abstract:
- lang: eng
text: 'Questions about lines in space arise frequently as subproblems in three-dimensional
computational geometry. In this paper we study a number of fundamental combinatorial
and algorithmic problems involving arrangements of n lines in three-dimensional
space. Our main results include: 1. A tight Θ(n2) bound on the maximum combinatorial
description complexity of the set of all oriented lines that have specified orientations
relative to the n given lines. 2. A similar bound of Θ(n3) for the complexity
of the set of all lines passing above the n given lines. 3. A preprocessing procedure
using O(n2+ε) time and storage, for any ε > 0, that builds a structure supporting
O(logn)-time queries for testing if a line lies above all the given lines. 4.
An algorithm that tests the "towering property" in O(n4/3+ε) time, for
any ε > 0: do n given red lines lie all above n given blue lines? The tools
used to obtain these and other results include Plücker coordinates for lines in
space and ε-nets for various geometric range spaces.'
acknowledgement: Work on this paper by Bernard Chazelle has been supported by NSF
Grant CCR-87-00917. Work on this paper by Herbert Edelsbrunner has been supported
by NSF Grant CCR-87-14565. Work on this paper by Leonidas Guibas has been supported
by grants from the Mitsubishi and Toshiba Corporations. Work on this paper by Micha
Sharir has been supported by ONR Grant N00014-87-K-0129, by NSF Grants DCR-83-20085
and CCR-89-01484, and by grants from the U.S.-Israeli Binational Science Foundation,
the NCRD — the Israeli National Council for Research and Development, and the EMET
Fund of the Israeli Academy of Sciences.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jorge
full_name: Stolfi, Jorge
last_name: Stolfi
citation:
ama: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. Lines in space:
Combinatorics and algorithms. Algorithmica. 1996;15(5):428-447. doi:10.1007/BF01955043'
apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., & Stolfi, J. (1996).
Lines in space: Combinatorics and algorithms. Algorithmica. Springer. https://doi.org/10.1007/BF01955043'
chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
and Jorge Stolfi. “Lines in Space: Combinatorics and Algorithms.” Algorithmica.
Springer, 1996. https://doi.org/10.1007/BF01955043.'
ieee: 'B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Stolfi, “Lines
in space: Combinatorics and algorithms,” Algorithmica, vol. 15, no. 5.
Springer, pp. 428–447, 1996.'
ista: 'Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Stolfi J. 1996. Lines in
space: Combinatorics and algorithms. Algorithmica. 15(5), 428–447.'
mla: 'Chazelle, Bernard, et al. “Lines in Space: Combinatorics and Algorithms.”
Algorithmica, vol. 15, no. 5, Springer, 1996, pp. 428–47, doi:10.1007/BF01955043.'
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Stolfi, Algorithmica
15 (1996) 428–447.
date_created: 2018-12-11T12:06:31Z
date_published: 1996-05-01T00:00:00Z
date_updated: 2022-08-09T09:55:46Z
day: '01'
doi: 10.1007/BF01955043
extern: '1'
intvolume: ' 15'
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 428 - 447
publication: Algorithmica
publication_identifier:
issn:
- 0178-4617
publication_status: published
publisher: Springer
publist_id: '2100'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lines in space: Combinatorics and algorithms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1996'
...
---
_id: '4030'
acknowledgement: article M-Pos412
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: Liang J, Edelsbrunner H, Subramaniam S. Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations. Vol 70.
Cell Press; 1996:A224-A224. doi:10.1016/S0006-3495(96)79664-9
apa: Liang, J., Edelsbrunner, H., & Subramaniam, S. (1996). Effects of molecular
shape representations on boundary element method for protein electrostatics computations.
Fortieth Annual Meeting (Vol. 70, pp. A224–A224). Cell Press. https://doi.org/10.1016/S0006-3495(96)79664-9
chicago: Liang, Jie, Herbert Edelsbrunner, and Shankar Subramaniam. Effects of
Molecular Shape Representations on Boundary Element Method for Protein Electrostatics
Computations. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79664-9.
ieee: J. Liang, H. Edelsbrunner, and S. Subramaniam, Effects of molecular shape
representations on boundary element method for protein electrostatics computations,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A224–A224.
ista: Liang J, Edelsbrunner H, Subramaniam S. 1996. Effects of molecular shape representations
on boundary element method for protein electrostatics computations, Cell Press,p.
mla: Liang, Jie, et al. “Effects of Molecular Shape Representations on Boundary
Element Method for Protein Electrostatics Computations.” Fortieth Annual Meeting,
vol. 70, no. 2, Part 2, Cell Press, 1996, pp. A224–A224, doi:10.1016/S0006-3495(96)79664-9.
short: J. Liang, H. Edelsbrunner, S. Subramaniam, Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations, Cell Press,
1996.
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-19T00:00:00Z
date_updated: 2022-08-08T10:22:38Z
day: '19'
doi: 10.1016/S0006-3495(96)79664-9
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796649?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A224 - A224
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2097'
status: public
title: Effects of molecular shape representations on boundary element method for protein
electrostatics computations
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4031'
acknowledgement: article W-AM-L6
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sudhakar
full_name: Pamidghantam, Sudhakar
last_name: Pamidghantam
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets. Vol 70.
Cell Press; 1996:A377-A377. doi:10.1016/S0006-3495(96)79670-4'
apa: 'Liang, J., Edelsbrunner, H., Pamidghantam, S., & Subramaniam, S. (1996).
Analytical method for molecular shapes: Area, volume, cavities, interface and
pockets. Fortieth Annual Meeting (Vol. 70, pp. A377–A377). Cell Press.
https://doi.org/10.1016/S0006-3495(96)79670-4'
chicago: 'Liang, Jie, Herbert Edelsbrunner, Sudhakar Pamidghantam, and Shankar Subramaniam.
Analytical Method for Molecular Shapes: Area, Volume, Cavities, Interface and
Pockets. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79670-4.'
ieee: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, and S. Subramaniam, Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A377–A377.'
ista: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. 1996. Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets, Cell
Press,p.'
mla: 'Liang, Jie, et al. “Analytical Method for Molecular Shapes: Area, Volume,
Cavities, Interface and Pockets.” Fortieth Annual Meeting, vol. 70, no.
2, Part 2, Cell Press, 1996, pp. A377–A377, doi:10.1016/S0006-3495(96)79670-4.'
short: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, S. Subramaniam, Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets, Cell Press,
1996.'
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-21T00:00:00Z
date_updated: 2022-08-08T10:21:56Z
day: '21'
doi: 10.1016/S0006-3495(96)79670-4
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796704?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A377 - A377
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2098'
status: public
title: 'Analytical method for molecular shapes: Area, volume, cavities, interface
and pockets'
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4142'
abstract:
- lang: eng
text: 'Mutations giving rise to anatomical defects in the inner ear have been isolated
in a large scale screen for mutations causing visible abnormalities in the zebrafish
embryo (Haffter, P., Granato, M., Brand, M. et al. (1996) Development 123, 1-36).
58 mutants have been classified as having a primary ear phenotype; these fall
into several phenotypic classes, affecting presence or size of the otoliths, size
and shape of the otic vesicle and formation of the semicircular canals, and define
at least 20 complementation groups. Mutations in seven genes cause loss of one
or both otoliths, but do not appear to affect development of other structures
within the ear. Mutations in seven genes affect morphology and patterning of the
inner ear epithelium, including formation of the semicircular canals and, in some,
development of sensory patches (maculae and cristae). Within this class, dog-eared
mutants show abnormal development of semicircular canals and lack cristae within
the ear, while in van gogh, semicircular canals fail to form altogether, resulting
in a tiny otic vesicle containing a single sensory patch. Both these mutants show
defects in the expression of homeobox genes within the otic vesicle. In a further
class of mutants, ear size is affected while patterning appears to be relatively
normal; mutations in three genes cause expansion of the otic vesicle, while in
little ears and microtic, the ear is abnormally small, but still contains all
five sensory patches, as in the wild type. Many of the ear and otolith mutants
show an expected behavioural phenotype: embryos fail to balance correctly, and
may swim on their sides, upside down, or in circles. Several mutants with similar
balance defects have also been isolated that have no obvious structural ear defect,
but that may include mutants with vestibular dysfunction of the inner ear (Granato,
M., van Eeden, F. J. M., Schach, U. et al. (1996) Development, 123, 399-413,).
Mutations in 19 genes causing primary defects in other structures also show an
ear defect. In particular, ear phenotypes are often found in conjunction with
defects of neural crest derivatives (pigment cells and/or cartilaginous elements
of the jaw). At least one mutant, dog-eared, shows defects in both the ear and
another placodally derived sensory system, the lateral line, while hypersensitive
mutants have additional trunk lateral line organs.'
acknowledgement: T. T. W. thanks all members of the Tübingen fish and fly groups for
their hospitality and generosity during her visits to the laboratory. We thank Julian
Lewis, in whose laboratory much of this work was carried out, for many helpful discussions
and suggestions, Catherine Haddon for advice on wild-type ear development and techniques,
and Stephen Massey for fish husbandry in Oxford. We are grateful to Julian Lewis,
Catherine Haddon, Nick Monk and Patrick Blader for comments on the manuscript, and
to Trevor Jowett, Tom Schilling,Eric Weinberg and Monte Westerfield for providing
cDNAs. We also thank Jarema Malicki and Wolfgang Driever for making some of the
Boston otolith mutants available before publication. T. T. W. thanks the EMBO (ASTF
7668; ASTF 7918), the Imperial Cancer Research Fund and the Wellcome Trust (03643/Z/92)
for support.
article_processing_charge: No
article_type: original
author:
- first_name: Tanya
full_name: Whitfield, Tanya
last_name: Whitfield
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Whitfield T, Granato M, Van Eeden F, et al. Mutations affecting development
of the zebrafish inner ear and lateral line. Development. 1996;123:241-254.
doi:10.1242/dev.123.1.241
apa: Whitfield, T., Granato, M., Van Eeden, F., Schach, U., Brand, M., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting development of the
zebrafish inner ear and lateral line. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.241
chicago: Whitfield, Tanya, Michael Granato, Fredericus Van Eeden, Ursula Schach,
Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Mutations Affecting
Development of the Zebrafish Inner Ear and Lateral Line.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.241.
ieee: T. Whitfield et al., “Mutations affecting development of the zebrafish
inner ear and lateral line,” Development, vol. 123. Company of Biologists,
pp. 241–254, 1996.
ista: Whitfield T, Granato M, Van Eeden F, Schach U, Brand M, Furutani Seiki M,
Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the
zebrafish inner ear and lateral line. Development. 123, 241–254.
mla: Whitfield, Tanya, et al. “Mutations Affecting Development of the Zebrafish
Inner Ear and Lateral Line.” Development, vol. 123, Company of Biologists,
1996, pp. 241–54, doi:10.1242/dev.123.1.241.
short: T. Whitfield, M. Granato, F. Van Eeden, U. Schach, M. Brand, M. Furutani
Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 241–254.
date_created: 2018-12-11T12:07:11Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:45:59Z
day: '01'
doi: 10.1242/dev.123.1.241
extern: '1'
external_id:
pmid:
- '9007244'
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 241 - 254
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1979'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting development of the zebrafish inner ear and lateral line
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4151'
abstract:
- lang: eng
text: 'Jaws and branchial arches together are a basic, segmented feature of the
vertebrate head, Seven arches develop in the zebrafish embryo (Danio rerio), derived
largely from neural crest cells that form the cartilaginous skeleton, In this
and the following paper we describe the phenotypes of 109 arch mutants, focusing
here on three classes that affect the posterior pharyngeal arches, including the
hyoid and five gill-bearing arches, In lockjaw, the hyoid arch is strongly reduced
and subsets of branchial arches do not develop, Mutants of a large second class,
designated the flathead group, lack several adjacent branchial arches and their
associated cartilages. Five alleles at the flathead locus all lead to larvae that
lack arches 4-6, Among 34 other flathead group members complementation tests are
incomplete, but at least six unique phenotypes can be distinguished, These all
delete continuous stretches of adjacent branchial arches and unpaired cartilages
in the ventral midline, Many show cell death in the midbrain, from which some
neural crest precursors of the arches originate, lockjaw and a few mutants in
the flathead group, including pistachio, affect both jaw cartilage and pigmentation,
reflecting essential functions of these genes in at least two neural crest lineages,
Mutants of a third class, including boxer, dackel and pincher, affect pectoral
fins and axonal trajectories in the brain, as well as the arches. Their skeletal
phenotypes suggest that they disrupt cartilage morphogenesis in all arches, Our
results suggest that there are sets of genes that: (1) specify neural crest cells
in groups of adjacent head segments, and (2) function in common genetic pathways
in a variety of tissues including the brain, pectoral fins and pigment cells as
well as pharyngeal arches.'
acknowledgement: We thank Drs Charles Kimmel, Philip Ingham, Paula Mabee and members
of the Ingham lab for critical comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Torsten
full_name: Trowe, Torsten
last_name: Trowe
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Schilling T, Piotrowski T, Grandel H, et al. Jaw and branchial arch mutants
in zebrafish I: Branchial arches. Development. 1996;123(1):329-344. doi:10.1242/dev.123.1.329'
apa: 'Schilling, T., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.-P. J.,
Jiang, Y., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in zebrafish
I: Branchial arches. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.329'
chicago: 'Schilling, Thomas, Tatjana Piotrowski, Heiner Grandel, Michael Brand,
Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, et al. “Jaw and Branchial
Arch Mutants in Zebrafish I: Branchial Arches.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.329.'
ieee: 'T. Schilling et al., “Jaw and branchial arch mutants in zebrafish
I: Branchial arches,” Development, vol. 123, no. 1. Company of Biologists,
pp. 329–344, 1996.'
ista: 'Schilling T, Piotrowski T, Grandel H, Brand M, Heisenberg C-PJ, Jiang Y,
Beuchle D, Hammerschmidt M, Kane D, Mullins M, Van Eeden F, Kelsh R, Furutani
Seiki M, Granato M, Haffter P, Odenthal J, Warga R, Trowe T, Nüsslein Volhard
C. 1996. Jaw and branchial arch mutants in zebrafish I: Branchial arches. Development.
123(1), 329–344.'
mla: 'Schilling, Thomas, et al. “Jaw and Branchial Arch Mutants in Zebrafish I:
Branchial Arches.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 329–44, doi:10.1242/dev.123.1.329.'
short: T. Schilling, T. Piotrowski, H. Grandel, M. Brand, C.-P.J. Heisenberg, Y.
Jiang, D. Beuchle, M. Hammerschmidt, D. Kane, M. Mullins, F. Van Eeden, R. Kelsh,
M. Furutani Seiki, M. Granato, P. Haffter, J. Odenthal, R. Warga, T. Trowe, C.
Nüsslein Volhard, Development 123 (1996) 329–344.
date_created: 2018-12-11T12:07:15Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:41:00Z
day: '01'
doi: 10.1242/dev.123.1.329
extern: '1'
external_id:
pmid:
- '9007253'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 329 - 344
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1968'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish I: Branchial arches'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4154'
abstract:
- lang: eng
text: As part of a large scale chemical mutagenesis screen of the zebrafish (Danio
rerio) genome, we have identified 33 mutants with defects in hematopoiesis, Complementation
analysis placed 32 of these mutants into 17 complementation groups, The allelism
of the remaining 1 blood mutant is currently unresolved, We have categorized these
blood mutants into four phenotypic classes based on analyses of whole embryos
and isolated blood cells, as well as by in situ hybridization using the hematopoietic
transcription factors GATA-1 and GATA-2, Embryos mutant for the gene moonshine
have few if any proerythroblasts visible on the day circulation begins and normal
erythroid cell differentiation is blocked as determined by staining for hemoglobin
and GATA-1 expression, Mutations in five genes, chablis, frascati, merlot, retsina,
thunderbird and two possibly unique mutations cause a progressive decrease in
the number of blood cells during the first 5 days of development, Mutations in
another seven genes, chardonnay, chianti, grenache, sauternes, weibherbst and
zinfandel, and two additional mutations result in hypochromic blood cells which
also decrease in number as development proceeds, Several of these mutants have
immature cells in the circulation, indicating a block in normal erythroid development.
The mutation in zinfandel is dominant, and 2-day old heterozygous carriers fail
to express detectable levels of hemoglobin and have decreasing numbers of circulating
cells during the first 5 days of development, Mutations in two genes, freixenet
and yquem, result in the animals that are photosensitive with autofluorescent
blood, similar to that found in the human congenital porphyrias, The collection
of mutants presented here represent several steps required for normal erythropoiesis,
The analysis of these mutants provides a powerful approach towards defining the
molecular mechanisms involved in vertebrate hematopoietic development.
acknowledgement: 'We thank Leonard Zon for his generous support of D. G. R. and A.
B., for critical review of this manuscript and for many helpful discussions. We
also thank Lauren Barone and Stephen Pratt for technical assistance. D. G. R. is
a postdoctoral fellow of the Howard Hughes Medical Institute. '
article_processing_charge: No
article_type: original
author:
- first_name: David
full_name: Ransom, David
last_name: Ransom
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Alison
full_name: Brownlie, Alison
last_name: Brownlie
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Ransom D, Haffter P, Odenthal J, et al. Characterization of zebrafish mutants
with defects in embryonic hematopoiesis. Development. 1996;123(1):311-319.
doi:10.1242/dev.123.1.311
apa: Ransom, D., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh,
R., … Nüsslein Volhard, C. (1996). Characterization of zebrafish mutants with
defects in embryonic hematopoiesis. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.311
chicago: Ransom, David, Pascal Haffter, Jörg Odenthal, Alison Brownlie, Elisabeth
Vogelsang, Robert Kelsh, Michael Brand, et al. “Characterization of Zebrafish
Mutants with Defects in Embryonic Hematopoiesis.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.311.
ieee: D. Ransom et al., “Characterization of zebrafish mutants with defects
in embryonic hematopoiesis,” Development, vol. 123, no. 1. Company of Biologists,
pp. 311–319, 1996.
ista: Ransom D, Haffter P, Odenthal J, Brownlie A, Vogelsang E, Kelsh R, Brand M,
Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang
Y, Kane D, Mullins M, Nüsslein Volhard C. 1996. Characterization of zebrafish
mutants with defects in embryonic hematopoiesis. Development. 123(1), 311–319.
mla: Ransom, David, et al. “Characterization of Zebrafish Mutants with Defects in
Embryonic Hematopoiesis.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 311–19, doi:10.1242/dev.123.1.311.
short: D. Ransom, P. Haffter, J. Odenthal, A. Brownlie, E. Vogelsang, R. Kelsh,
M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J.
Heisenberg, Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123
(1996) 311–319.
date_created: 2018-12-11T12:07:16Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:23:35Z
day: '01'
doi: 10.1242/dev.123.1.311
extern: '1'
external_id:
pmid:
- '9007251'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 311 - 319
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1966'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Characterization of zebrafish mutants with defects in embryonic hematopoiesis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4156'
abstract:
- lang: eng
text: 'In a large scale screen for mutants that affect the early development of
the zebrafish, 109 mutants were found that cause defects in the formation of the
jaw and the more posterior pharyngeal arches, Here we present the phenotypic description
and results of the complementation analysis of mutants belonging to two major
classes: (1) mutants with defects in the mandibular and hyoid arches and (2) mutants
with defects in cartilage differentiation and growth in all arches, Mutations
in four of the genes identified during the screen show specific defects in the
first two arches and leave the more posterior pharyngeal arches largely unaffected
(schmerle, sucker, hoover and sturgeon). In these mutants ventral components of
the mandibular and hyoid arches are reduced (Meckel''s cartilage and ceratohyal
cartilage) whereas dorsal structures (palato-quadrate and hyosymplectic cartilages)
are of normal size or enlarged, Thus, mutations in single genes cause defects
in the formation of first and second arch structures but also differentially affect
development of the dorsal and ventral structures within one arch. In 27 mutants
that define at least 8 genes, the differentiation of cartilage and growth is affected.
In hammerhead mutants particularly the mesodermally derived cartilages are reduced,
whereas jellyfish mutant larvae are characterized by a severe reduction of all
cartilaginous elements, leaving only two pieces in the position of the ceratohyal
cartilages. In all other mutant larvae all skeletal elements are present, but
consist of smaller and disorganized chondrocytes. These mutants also exhibit shortened
heads and reduced pectoral fins. In homozygous knorrig embryos, tumor-like outgrowths
of chondrocytes occur along the edges of all cartilaginous elements. The mutants
presented here may be valuable tools for elucidating the genetic mechanisms that
underlie the development of the mandibular and the hyoid arches, as well as the
process of cartilage differentiation.'
acknowledgement: We would like to thank Siegfried Roth, Stefan Schulte-Merker and
Tanya Whitfield for critically reading the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Tatjana
full_name: Piotrowski, Tatjana
last_name: Piotrowski
- first_name: Thomas
full_name: Schilling, Thomas
last_name: Schilling
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Heiner
full_name: Grandel, Heiner
last_name: Grandel
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Piotrowski T, Schilling T, Brand M, et al. Jaw and branchial arch mutants
in zebrafish II: Anterior arches and cartilage differentiation. Development.
1996;123(1):345-356. doi:10.1242/dev.123.1.345'
apa: 'Piotrowski, T., Schilling, T., Brand, M., Jiang, Y., Heisenberg, C.-P. J.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Jaw and branchial arch mutants in
zebrafish II: Anterior arches and cartilage differentiation. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.345'
chicago: 'Piotrowski, Tatjana, Thomas Schilling, Michael Brand, Yunjin Jiang, Carl-Philipp
J Heisenberg, Dirk Beuchle, Heiner Grandel, et al. “Jaw and Branchial Arch Mutants
in Zebrafish II: Anterior Arches and Cartilage Differentiation.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.345.'
ieee: 'T. Piotrowski et al., “Jaw and branchial arch mutants in zebrafish
II: Anterior arches and cartilage differentiation,” Development, vol. 123,
no. 1. Company of Biologists, pp. 345–356, 1996.'
ista: 'Piotrowski T, Schilling T, Brand M, Jiang Y, Heisenberg C-PJ, Beuchle D,
Grandel H, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt
M, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996.
Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation. Development. 123(1), 345–356.'
mla: 'Piotrowski, Tatjana, et al. “Jaw and Branchial Arch Mutants in Zebrafish II:
Anterior Arches and Cartilage Differentiation.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 345–56, doi:10.1242/dev.123.1.345.'
short: T. Piotrowski, T. Schilling, M. Brand, Y. Jiang, C.-P.J. Heisenberg, D. Beuchle,
H. Grandel, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt,
D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development
123 (1996) 345–356.
date_created: 2018-12-11T12:07:17Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:13:07Z
day: '01'
doi: 10.1242/dev.123.1.345
extern: '1'
external_id:
pmid:
- '9007254 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 345 - 356
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1963'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Jaw and branchial arch mutants in zebrafish II: Anterior arches and cartilage
differentiation'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4164'
abstract:
- lang: eng
text: In a large-scale screen for mutants with defects in embryonic development
we identified 17 genes (65 mutants) specifically required for the development
of xanthophores, We provide evidence that these genes are required for three different
aspects of xanthophore development, (1) Pigment cell formation and migration (pfeffer
and salt); (2) pigment synthesis (edison, yobo, yocca and brie) and (3) pigment
translocation (esrom, tilsit and tofu). The number of xanthophore cells that appear
in the body is reduced in embryos with mutations in the two genes, salt and pfeffer.
In heterozygous and homozygous salt and pfeffer adults, the melanophore stripes
are interrupted, indicating that xanthophore cells have an important function
in adult melanophore pattern formation, Most other genes affect only larval pigmentation,
In embryos mutant for edison, yobo, yocca and brie, differences in pteridine synthesis
can be observed under UV light and by thin-layer chromatography. Homozygous mutant
females of yobo show a recessive maternal effect, Embryonic development is slowed
down and embryos display head and tail truncations, Xanthophores in larvae mutant
in the three genes esrom, tilsit and tofu appear less spread out, In addition,
these mutants display a defect in retinotectal axon pathfinding, These mutations
may affect xanthophore pigment distribution within the cells or xanthophore cell
shape, Mutations in seven genes affecting xanthophore pigmentation remain unclassified.
acknowledgement: We thank Silke Rudolph for technical assistance, Joel Wilson and
Cornelia Fricke for their help in the fish work and the thin layer chromatography,
and Darren Gilmour for help with the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Karin
full_name: Rossnagel, Karin
last_name: Rossnagel
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Odenthal J, Rossnagel K, Haffter P, et al. Mutations affecting xanthophore
pigmentation in the zebrafish, Danio rerio. Development. 1996;123(1):391-398.
doi:10.1242/dev.123.1.391
apa: Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R., Vogelsang, E., Brand,
M., … Nüsslein Volhard, C. (1996). Mutations affecting xanthophore pigmentation
in the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.391
chicago: Odenthal, Jörg, Karin Rossnagel, Pascal Haffter, Robert Kelsh, Elisabeth
Vogelsang, Michael Brand, Fredericus Van Eeden, et al. “Mutations Affecting Xanthophore
Pigmentation in the Zebrafish, Danio Rerio.” Development. Company of Biologists,
1996. https://doi.org/10.1242/dev.123.1.391.
ieee: J. Odenthal et al., “Mutations affecting xanthophore pigmentation in
the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of Biologists,
pp. 391–398, 1996.
ista: Odenthal J, Rossnagel K, Haffter P, Kelsh R, Vogelsang E, Brand M, Van Eeden
F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane
D, Mullins M, Nüsslein Volhard C. 1996. Mutations affecting xanthophore pigmentation
in the zebrafish, Danio rerio. Development. 123(1), 391–398.
mla: Odenthal, Jörg, et al. “Mutations Affecting Xanthophore Pigmentation in the
Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 391–98, doi:10.1242/dev.123.1.391.
short: J. Odenthal, K. Rossnagel, P. Haffter, R. Kelsh, E. Vogelsang, M. Brand,
F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg,
Y. Jiang, D. Kane, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 391–398.
date_created: 2018-12-11T12:07:20Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:08:51Z
day: '01'
doi: 10.1242/dev.123.1.391
extern: '1'
external_id:
pmid:
- '9007257 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 391 - 398
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1955'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4166'
abstract:
- lang: eng
text: In a large scale screen for mutants with defects in the embryonic development
of the zebrafish we identified mutations in four genes, floating head (flh), memo
(mom), no tail (ntl), and dec, that are required for early notochord formation.
Mutations in flh and ntl have been described previously, while mom and doe are
newly identified genes. Mutant mom embryos lack a notochord in the trunk, and
trunk somites from the right and left side of the embryo fuse underneath the neural
tube. In this respect morn appears similar to flh. In contrast, notochord precursor
cells are present in both ntl and doc embryos. In order to gain a greater understanding
of the phenotypes, we have analysed the expression of several axial mesoderm markers
in mutant embryos of all four genes. In flh and mom, Ntl expression is normal
in the germ ring and tailbud, while the expression of Nd and other notochord markers
in the axial mesodermal region is disrupted. Nd expression is normal in doc embryos
until early semitic stages, when there is a reduction in expression which is first
seen in anterior regions of the embryo. This suggests a function for doc in the
maintenance of ntl expression. Other notochord markers such as twist, sonic hedgehog
and axial are not expressed in the axial mesoderm of ntl embryos, their expression
parallels the expression of ntl in the axial mesoderm of mutant doc,flh and mom
embryos, indicating that ntl is required for the expression of these markers.
The role of doc in the expression of the notochord markers appears indirect via
ntl. Floor plate formation is disrupted in most regions in flh and mom mutant
embryos but is present in mutant ntl and doc embryos. In mutant embryos with strong
ntl alleles the band of cells expressing floor plate markers is broadened. A similar
broadening is also observed in the axial mesoderm underlying the floor plate of
ntl embryos, suggesting a direct involvement of the notochord precursor cells
in floor plate induction. Mutations in al of these four genes result in embryos
lacking a horizontal myoseptum and muscle pioneer cells, both of which are thought
to be induced by the notochord. These somite defects can be traced back to an
impairment of the specification of the adaxial cells during early stages of development.
Transplantation of wild-type cells into mutant doc embryos reveals that wild-type
notochord cells are sufficient to induce horizontal myoseptum formation in the
flanking mutant tissue. Thus dec, like flh and ntl, acts cell autonomously in
the notochord. In addition to the four mutants with defects in early notochord
formation, we have isolated 84 mutants, defining at least 15 genes, with defects
in later stages of notochord development. These are listed in an appendix to this
study.
acknowledgement: We thank Bob Riggleman for providing the twist probe prior to publication,
William Talbot, Anne Melby, Marnie Halpern and Chuck Kimmel for communicating results
prior to publication, Bill Trevarrow for the flhn1 allele, Stefan Schulte-Merker
for providing the ntl antibody, and N. H. Patel for providing the Eng antibody (4D9).
We thank Klaus Trummler, Frank Uhlmann and Mathias Metz for assistance in the analysis
of the ntl alleles, Silke Rudolph for technical assistance, Heike Schauerte for
helping with the in situ hybridization, and Joel Wilson and Cornelia Fricke for
their help with the fish work, and finally Tanya Whitfield, Francisco Pelegri, Darren
Gilmour and Stefan Schulte-Merker for discussion and help with the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Miguel
full_name: Allende, Miguel
last_name: Allende
- first_name: Eric
full_name: Weinberg, Eric
last_name: Weinberg
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Odenthal J, Haffter P, Vogelsang E, et al. Mutations affecting the formation
of the notochord in the zebrafish, Danio rerio. Development. 1996;123(1):103-115.
doi:10.1242/dev.123.1.103
apa: Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., Van Eeden, F., Furutani
Seiki, M., … Nüsslein Volhard, C. (1996). Mutations affecting the formation of
the notochord in the zebrafish, Danio rerio. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.103
chicago: Odenthal, Jörg, Pascal Haffter, Elisabeth Vogelsang, Michael Brand, Fredericus
Van Eeden, Makoto Furutani Seiki, Michael Granato, et al. “Mutations Affecting
the Formation of the Notochord in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.103.
ieee: J. Odenthal et al., “Mutations affecting the formation of the notochord
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 103–115, 1996.
ista: Odenthal J, Haffter P, Vogelsang E, Brand M, Van Eeden F, Furutani Seiki M,
Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins
M, Warga R, Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting
the formation of the notochord in the zebrafish, Danio rerio. Development. 123(1),
103–115.
mla: Odenthal, Jörg, et al. “Mutations Affecting the Formation of the Notochord
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 103–15, doi:10.1242/dev.123.1.103.
short: J. Odenthal, P. Haffter, E. Vogelsang, M. Brand, F. Van Eeden, M. Furutani
Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R.
Kelsh, M. Mullins, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development
123 (1996) 103–115.
date_created: 2018-12-11T12:07:21Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-08T08:06:12Z
day: '01'
doi: 10.1242/dev.123.1.103
extern: '1'
external_id:
pmid:
- '9007233'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://journals.biologists.com/dev/article/123/1/103/39325/Mutations-affecting-the-formation-of-the-notochord
month: '12'
oa: 1
oa_version: Published Version
page: 103 - 115
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1954'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting the formation of the notochord in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4170'
abstract:
- lang: eng
text: We identified 6 genes that are essential for specifying ventral regions of
the early zebrafish embryo, Mutations in these genes cause an expansion of structures
normally derived from dorsal-lateral regions of the blastula at the expense of
ventrally derived structures, A series of phenotypes of varied strengths is observed
with different alleles of these mutants, The weakest phenotype is a reduction
in the ventral tail fin, observed as a dominant phenotype of swirl, piggytail,
and somitabun and a recessive phenotype of min fin, lost-a-fin and some piggytail
alleles, With increasing phenotypic strength, the blood and pronephric anlagen
are also reduced or absent, while the paraxial mesoderm and anterior neuroectoderm
is progressively expanded, In the strong phenotypes, displayed by homozygous embryos
of snailhouse, swirl and somitabun, the somites circle around the embryo and the
midbrain region is expanded laterally, Several mutations in this group of genes
are semidominant as well as recessive indicating a strong dosage sensitivity of
the processes involved, Mutations in the piggytail gene display an unusual dominance
that depends on both a maternal and zygotic heterozygous genotype, while somitabun
is a fully penetrant dominant maternal-effect mutation, The similar and overlapping
phenotypes of mutants of the 6 genes identified suggest that they function in
a common pathway, which begins in oogenesis, but also depends on factors provided
after the onset of zygotic transcription, presumably during blastula stages, This
pathway provides ventral positional information, counteracting the dorsalizing
instructions of the organizer, which is localized in the dorsal shield.
acknowledgement: 'We would like to thank: Eric Weinberg, and David Ransom and Leonard
Zon for providing the myoD and gata1 cDNA clone, respectively, prior to publication;
David Ransom for pointing out the histological blood staining method; J. S. Joly
for the eve1 cDNA clone; Mary Ellen Lane, Siegfried Roth, Stefan Schulte-Merker,
Herbert Steinbeiser for helpful comments on the manuscript; and very special thanks
to Karin Finger-Miller for technical support, as well as to Hans-Martin Maischein,
Amanda Wilson, Jörg Zeller, and Cosima Fabian. This work was supported by an NIH
postdoctoral fellowship to M. C. M.'
article_processing_charge: No
article_type: original
author:
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: 'Mullins M, Hammerschmidt M, Kane D, et al. Genes establishing dorsoventral
pattern formation in the zebrafish embryo: The ventral specifying genes. Development.
1996;123(1):81-93. doi:10.1242/dev.123.1.81'
apa: 'Mullins, M., Hammerschmidt, M., Kane, D., Odenthal, J., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes establishing dorsoventral pattern formation
in the zebrafish embryo: The ventral specifying genes. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.81'
chicago: 'Mullins, Mary, Matthias Hammerschmidt, Donald Kane, Jörg Odenthal, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Establishing
Dorsoventral Pattern Formation in the Zebrafish Embryo: The Ventral Specifying
Genes.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.81.'
ieee: 'M. Mullins et al., “Genes establishing dorsoventral pattern formation
in the zebrafish embryo: The ventral specifying genes,” Development, vol.
123, no. 1. Company of Biologists, pp. 81–93, 1996.'
ista: 'Mullins M, Hammerschmidt M, Kane D, Odenthal J, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Nüsslein Volhard
C. 1996. Genes establishing dorsoventral pattern formation in the zebrafish embryo:
The ventral specifying genes. Development. 123(1), 81–93.'
mla: 'Mullins, Mary, et al. “Genes Establishing Dorsoventral Pattern Formation in
the Zebrafish Embryo: The Ventral Specifying Genes.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 81–93, doi:10.1242/dev.123.1.81.'
short: M. Mullins, M. Hammerschmidt, D. Kane, J. Odenthal, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
C. Nüsslein Volhard, Development 123 (1996) 81–93.
date_created: 2018-12-11T12:07:22Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T12:01:06Z
day: '01'
doi: 10.1242/dev.123.1.81
extern: '1'
external_id:
pmid:
- '9007231'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 81 - 93
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1951'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Genes establishing dorsoventral pattern formation in the zebrafish embryo:
The ventral specifying genes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4186'
abstract:
- lang: eng
text: 'Neural crest development involves cell-fate specification, proliferation,
patterned cell migration, survival and differentiation, Zebrafish neural crest
derivatives include three distinct chromatophores, which are well-suited to genetic
analysis of their development, As part of a large-scale mutagenesis screen for
embryonic/early larval mutations, we have isolated 285 mutations affecting all
aspects of zebrafish larval pigmentation, By complementation analysis, we define
94 genes, We show here that comparison of their phenotypes permits classification
of these mutations according to the types of defects they cause, and these suggest
which process of neural crest development is probably affected, Mutations in eight
genes affect the number of chromatophores: these include strong candidates for
genes necessary for the processes of pigment cell specification and proliferation,
Mutations in five genes remove part of the wild-type pigment pattern, and suggest
a role in larval pigment pattern formation, Mutations in five genes show ectopic
chromatophores in distinct sites, and may have implications for chromatophore
patterning and proliferation, 76 genes affect pigment or morphology of one or
more chromatophore types: these mutations include strong candidates for genes
important in various aspects of chromatophore differentiation and survival, In
combination with the embryological advantages of zebrafish, these mutations should
permit cellular and molecular dissection of many aspects of neural crest development.'
acknowledgement: We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and
Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral
Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Lisa
full_name: Vogelsang, Lisa
last_name: Vogelsang
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the
processes of neural crest development. Development. 1996;123(1):369-389.
doi:10.1242/dev.123.1.369
apa: Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P.,
… Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes
of neural crest development. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.369
chicago: Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg,
Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations
and the Processes of Neural Crest Development.” Development. Company of
Biologists, 1996. https://doi.org/10.1242/dev.123.1.369.
ieee: R. Kelsh et al., “Zebrafish pigmentation mutations and the processes
of neural crest development,” Development, vol. 123, no. 1. Company of
Biologists, pp. 369–389, 1996.
ista: Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J,
Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D,
Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation
mutations and the processes of neural crest development. Development. 123(1),
369–389.
mla: Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of
Neural Crest Development.” Development, vol. 123, no. 1, Company of Biologists,
1996, pp. 369–89, doi:10.1242/dev.123.1.369.
short: R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J.
Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development
123 (1996) 369–389.
date_created: 2018-12-11T12:07:28Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T11:16:49Z
day: '01'
doi: 10.1242/dev.123.1.369
extern: '1'
external_id:
pmid:
- '9007256 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 369 - 389
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1933'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zebrafish pigmentation mutations and the processes of neural crest development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4188'
abstract:
- lang: eng
text: 'Epiboly, the enveloping of the yolk cell by the blastoderm, is the first
zebrafish morphogenetic movement, We isolated four mutations that affect epiboly:
half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal
progress of the deep cells of the blastoderm; only the yolk syncytial layer of
the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole
of the embryo, The mutations half baked, avalanche and lawine produce a novel
dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos
produced from heterozygous females slow down epiboly and accumulate detached cells
over the neural tube; a small fraction of these mutant individuals are viable,
Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type
females complete epiboly normally and are completely viable. Additionally, embryos
heterozygous for half baked have an enlarged hatching gland, a partial dominant
phenotype, The phenotypes of these mutants demonstrate that, for the spreading
of cells during epiboly, the movement of the deep cells of the blastoderm require
the function of genes that are not necessary for the movement of the enveloping
layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes
illustrate the maternal and zygotic interplay of genes that orchestrate the early
cell movements of the zebrafish.'
acknowledgement: We thank Drs John Postlethwait and Sigfreid Roth for their helpful
comments on earlier drafts of this paper. This work was supported in part by a grant
from the National Institutes of Health to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. Development.
1996;123(1):47-55. doi:10.1242/dev.123.1.47
apa: Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.47
chicago: Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael
Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.47 .
ieee: D. Kane et al., “The zebrafish epiboly mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.
ista: Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development.
123(1), 47–55.
mla: Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” Development, vol.
123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:10.1242/dev.123.1.47 .
short: D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:22:40Z
day: '01'
doi: '10.1242/dev.123.1.47 '
extern: '1'
external_id:
pmid:
- '9007228 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 47 - 55
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1930'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish epiboly mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4189'
abstract:
- lang: eng
text: 'This report describes mutants of the zebrafish having phenotypes causing
a general arrest in early morphogenesis. These mutants identify a group of loci
making up about 20% of the loci identified by mutants with visible morphological
phenotypes within the first day of development. There are 12 Class I mutants,
which fall into 5 complementation groups and have cells that lyse before morphological
defects are observed. Mutants at three loci, speed bump, ogre and zombie, display
abnormal nuclei. The 8 Class II mutants, which fall into 6 complementation groups,
arrest development before cell lysis is observed. These mutants seemingly stop
development in the late segmentation stages, and maintain a body shape similar
to a 20 hour embryo. Mutations in speed bump, ogre, zombie, specter, poltergeist
and troll were tested for cell lethality by transplanting mutant cells into wild-type
hosts. With poltergeist, transplanted mutant cells all survive. The remainder
of the mutants tested were autonomously but conditionally lethal: mutant cells,
most of which lyse, sometimes survive to become notochord, muscles, or, in rare
cases, large neurons, all cell types which become postmitotic in the gastrula.
Some of the genes of the early arrest group may be necessary for progression though
the cell cycle; if so, the survival of early differentiating cells may be based
on having their terminal mitosis before the zygotic requirement for these genes.'
acknowledgement: We thank Dr Adam Felsenfeld for his careful comments on earlier drafts
of this manuscript, D. A. K. also thanks the two anonymous referees who patiently
pointed out a number of ‘speed bumps’ in the first submitted draft of this manuscript.
This work was supported in part by a grant from the National Institutes of Health
to D. A. K.
article_processing_charge: No
article_type: original
author:
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Hans
full_name: Maischein, Hans
last_name: Maischein
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Kane D, Maischein H, Brand M, et al. The zebrafish early arrest mutants. Development.
1996;123(1):57-66. doi:10.1242/dev.123.1.57
apa: Kane, D., Maischein, H., Brand, M., Van Eeden, F., Furutani Seiki, M., Granato,
M., … Nüsslein Volhard, C. (1996). The zebrafish early arrest mutants. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.57
chicago: Kane, Donald, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto
Furutani Seiki, Michael Granato, Pascal Haffter, et al. “The Zebrafish Early Arrest
Mutants.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.57 .
ieee: D. Kane et al., “The zebrafish early arrest mutants,” Development,
vol. 123, no. 1. Company of Biologists, pp. 57–66, 1996.
ista: Kane D, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter
P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kelsh R, Mullins M, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. The zebrafish early arrest mutants. Development.
123(1), 57–66.
mla: Kane, Donald, et al. “The Zebrafish Early Arrest Mutants.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 57–66, doi:10.1242/dev.123.1.57 .
short: D. Kane, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato,
P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, M. Mullins,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 57–66.
date_created: 2018-12-11T12:07:29Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:43:44Z
day: '01'
doi: '10.1242/dev.123.1.57 '
extern: '1'
external_id:
pmid:
- '9007229 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 57 - 66
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The zebrafish early arrest mutants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4191'
abstract:
- lang: eng
text: In a screen for embryonic mutants in the zebrafish a large number of mutants
were isolated with abnormal brain morphology, We describe here 26 mutants in 13
complementation groups that show abnormal development of large regions of the
brain, Early neurogenesis is affected in white tail (wit), During segmentation
stages, homozygous wit embryos display an irregularly formed neural keel, particularly
in the hindbrain, Using a variety of molecular markers, a severe increase in the
number of various early differentiating neurons can be demonstrated, In contrast,
late differentiating neurons, radial glial cells and some nonneural cell types,
such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis
appears delayed, In addition, very reduced numbers of melanophores are present
posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants
in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general
organization of the hindbrain is disturbed and many rounded cells accumulate loosely
in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk),
natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop
collapsed brain ventricles, before showing signs of general degeneration, atlantis
(atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele)
mutants have different malformation of the brain folds, Some of them have transient
phenotypes, and mutant individuals may grow up to adults.
acknowledgement: We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield,
Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse
Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan
and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants
to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J.
J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).
article_processing_charge: No
article_type: original
author:
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis
and brain morphology in the zebrafish, Danio rerio. Development. 1996;123(1):205-216.
doi:10.1242/dev.123.1.205
apa: Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M.,
Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and
brain morphology in the zebrafish, Danio rerio. Development. Company of
Biologists. https://doi.org/10.1242/dev.123.1.205
chicago: Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle,
Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting
Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.205.
ieee: Y. Jiang et al., “Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio,” Development, vol. 123, no. 1. Company of
Biologists, pp. 205–216, 1996.
ista: Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga
R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden
F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology
in the zebrafish, Danio rerio. Development. 123(1), 205–216.
mla: Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology
in the Zebrafish, Danio Rerio.” Development, vol. 123, no. 1, Company of
Biologists, 1996, pp. 205–16, doi:10.1242/dev.123.1.205.
short: Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R.
Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins,
J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.
date_created: 2018-12-11T12:07:30Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T09:13:51Z
day: '01'
doi: 10.1242/dev.123.1.205
extern: '1'
external_id:
pmid:
- '9007241'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 205 - 216
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1926'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio
rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4203'
abstract:
- lang: eng
text: 'We identified four zebrafish mutants with defects in forebrain induction
and patterning during embryogenesis. The four mutants define three genes: masterblind
(mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain
acquires posterior forebrain characteristics: anterior structures such as the
eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis
located in the posterior forebrain is expanded, In slb embryos, the extension
of the embryonic axis is initially delayed and eventually followed by a partial
fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia
is incomplete and dorsal midline cells fail to form a differentiated roof plate,
Analysis of the mutant phenotypes indicates that we have identified genes essential
for the specification of the anterior forebrain (mbl), positioning of the eyes
(slb) and differentiation of the roof plate (kas). In an appendix to this study
we list mutants showing alterations in the size of the eyes and abnormal differentiation
of the lenses.'
acknowledgement: We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b
cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and
V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for
help with the initial characterization of the mbl phenotype and many valuable comments
on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan,
Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of
the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development
in the zebrafish, Danio rerio. Development. 1996;123:191-203. doi:10.1242/dev.123.1.191
apa: Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in
the zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.191
chicago: Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga,
Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved
in Forebrain Development in the Zebrafish, Danio Rerio.” Development. Company
of Biologists, 1996. https://doi.org/10.1242/dev.123.1.191
.
ieee: C.-P. J. Heisenberg et al., “Genes involved in forebrain development
in the zebrafish, Danio rerio,” Development, vol. 123. Company of Biologists,
pp. 191–203, 1996.
ista: Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal
J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish,
Danio rerio. Development. 123, 191–203.
mla: Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development
in the Zebrafish, Danio Rerio.” Development, vol. 123, Company of Biologists,
1996, pp. 191–203, doi:10.1242/dev.123.1.191
.
short: C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.
date_created: 2018-12-11T12:07:34Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T08:06:15Z
day: '01'
doi: '10.1242/dev.123.1.191 '
extern: '1'
external_id:
pmid:
- '9007240 '
intvolume: ' 123'
language:
- iso: eng
month: '12'
oa_version: None
page: 191 - 203
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genes involved in forebrain development in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4208'
abstract:
- lang: eng
text: 'We have identified several genes that are required for various morphogenetic
processes during gastrulation and tail formation, Two genes are required in the
anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns).
oep mutant embryos are defective in prechordal plate formation and the specification
of anterior and ventral structures of the central nervous system, In dns mutants,
cells of the prechordal plate, such as the prospective hatching gland cells, fail
to specify. Two genes are required for convergence and extension movements. In
mutant trilobite embryos, extension movements on the dorsal side of the embryo
are affected, whereas in the formerly described spadetail mutants, for which two
new alleles have been isolated, convergent movements of ventrolateral cells to
the dorsal side are blocked. Two genes are required for the development of the
posterior end of the body axis, In pipetail mutants, the tailbud fails to move
ventrally on the yolk sac after germ ring closure, and the tip of the tail fails
to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube
at the posterior side of the yolk sac.'
acknowledgement: M. H. and F. P. contributed equally to this work. We are very grateful
to Dr Andrew McMahon, in whose laboratory much of the mutant analysis has been carried
out. Additionally, we would like to thank Ed Sullivan for his help and advice during
the setting-up of a fish facility in the McMahon laboratory. Dr Eric Weinberg generously
supplied us with the myoD cDNA prior to publication. Published reagents were obtained
from Drs Marie-Andrée Akimenko, Jean Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Mutations affecting morphogenesis
during gastrulation and tail formation in the zebrafish, Danio rerio. Development.
1996;123(1):143-151. doi:10.1242/dev.123.1.143
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Brand, M., Van Eeden,
F., … Nüsslein Volhard, C. (1996). Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. Company
of Biologists. https://doi.org/10.1242/dev.123.1.143
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations
Affecting Morphogenesis during Gastrulation and Tail Formation in the Zebrafish,
Danio Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.143.
ieee: M. Hammerschmidt et al., “Mutations affecting morphogenesis during
gastrulation and tail formation in the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 143–151, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Brand M, Van Eeden F, Furutani
Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Mutations affecting morphogenesis during gastrulation
and tail formation in the zebrafish, Danio rerio. Development. 123(1), 143–151.
mla: Hammerschmidt, Matthias, et al. “Mutations Affecting Morphogenesis during Gastrulation
and Tail Formation in the Zebrafish, Danio Rerio.” Development, vol. 123,
no. 1, Company of Biologists, 1996, pp. 143–51, doi:10.1242/dev.123.1.143.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, M. Brand, F. Van Eeden,
M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 143–151.
date_created: 2018-12-11T12:07:35Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-05T06:59:42Z
day: '01'
doi: 10.1242/dev.123.1.143
extern: '1'
external_id:
pmid:
- '9007236'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 143 - 151
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1908'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting morphogenesis during gastrulation and tail formation in
the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4210'
abstract:
- lang: eng
text: Mutations causing a visible phenotype in the adult serve as valuable visible
genetic markers in multicellular genetic model organisms such as Drosophila melanogaster,
Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations
affecting early development of the zebrafish, we identified a number of mutations
that are homozygous viable or semiviable. Here we describe viable mutations which
produce visible phenotypes in the adult fish. These predominantly affect the fins
and pigmentation, but also the eyes and body length of the adult. A number of
dominant mutations caused visible phenotypes in the adult fish, Mutations in three
genes, long fin, another long fin and wanda affected fin formation in the adult.
Four mutations were found to cause a dominant reduction of the overall body length
in the adult. The adult pigment pattern was found to be changed by dominant mutations
in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations
producing visible phenotypes in the homozygous adult, a group of mutations that
failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy
produced embryos that failed to express tyrosinase activity. These are potentially
useful for using tyrosinase as a marker for the generation of transgenic lines
of zebrafish.
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Shuo
full_name: Lin, Shuo
last_name: Lin
- first_name: Michael
full_name: Farrell, Michael
last_name: Farrell
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Fabian
full_name: Haas, Fabian
last_name: Haas
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Nancy
full_name: Hopkins, Nancy
last_name: Hopkins
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Odenthal J, Mullins M, et al. Mutations affecting pigmentation and
shape of the adult zebrafish. Development Genes and Evolution. 1996;206(4):260-276.
doi:10.1007/s004270050051
apa: Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E.,
… Nüsslein Volhard, C. (1996). Mutations affecting pigmentation and shape of the
adult zebrafish. Development Genes and Evolution. Springer. https://doi.org/10.1007/s004270050051
chicago: Haffter, Pascal, Jörg Odenthal, Mary Mullins, Shuo Lin, Michael Farrell,
Elisabeth Vogelsang, Fabian Haas, et al. “Mutations Affecting Pigmentation and
Shape of the Adult Zebrafish.” Development Genes and Evolution. Springer,
1996. https://doi.org/10.1007/s004270050051.
ieee: P. Haffter et al., “Mutations affecting pigmentation and shape of the
adult zebrafish,” Development Genes and Evolution, vol. 206, no. 4. Springer,
pp. 260–276, 1996.
ista: Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, Haas F, Brand
M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ,
Jiang Y, Kane D, Kelsh R, Hopkins N, Nüsslein Volhard C. 1996. Mutations affecting
pigmentation and shape of the adult zebrafish. Development Genes and Evolution.
206(4), 260–276.
mla: Haffter, Pascal, et al. “Mutations Affecting Pigmentation and Shape of the
Adult Zebrafish.” Development Genes and Evolution, vol. 206, no. 4, Springer,
1996, pp. 260–76, doi:10.1007/s004270050051.
short: P. Haffter, J. Odenthal, M. Mullins, S. Lin, M. Farrell, E. Vogelsang, F.
Haas, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, N. Hopkins, C. Nüsslein Volhard,
Development Genes and Evolution 206 (1996) 260–276.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-11-27T00:00:00Z
date_updated: 2022-08-04T14:45:21Z
day: '27'
doi: 10.1007/s004270050051
extern: '1'
external_id:
pmid:
- '24173565'
intvolume: ' 206'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 260 - 276
pmid: 1
publication: Development Genes and Evolution
publication_identifier:
issn:
- 0043-5546
publication_status: published
publisher: Springer
publist_id: '1906'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting pigmentation and shape of the adult zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 206
year: '1996'
...
---
_id: '4211'
abstract:
- lang: eng
text: We describe two genes, dino and mercedes, which are required for the organization
of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the
expense of the head and the anterior region of the trunk, The altered expression
patterns of various marker genes reveal that, with the exception of the dorsal
most marginal zone, all regions of the early dine mutant embryo acquire more ventral
fates, These alterations are already apparent before the onset of gastrulation,
mercedes mutant embryos show a similar but weaker phenotype, suggesting a role
in the same patterning processes. The phenotypes suggests that dine and mercedes
are required for the establishment of dorsal fates in both the marginal and the
animal zone of the early gastrula embryo, Their function in the patterning of
the ventrolateral mesoderm and the induction of the neuroectoderm is similar to
the function of the Spemann organizer in the amphibian embryo.
acknowledgement: "We are very grateful to Dr Andrew McMahon in whose laboratory much
of the mutant analysis has been carried out. Additionally, we would like to thank
Ed Sullivan for his help and advice during the setting up of a fish facility in
the McMahon laboratory. Drs Eric Weinberg and Leonard Zon generously supplied us
with reagents prior to publication. Published reagents were obtained from Drs Jon
Graff, Jean-Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.\r\nDrs Mary
Dickinson, Andrew McMahon, Siegfried Roth and Stefan Schulte-Merker read earlier
versions of the Manuscript. "
article_processing_charge: No
article_type: original
author:
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Francisco
full_name: Pelegri, Francisco
last_name: Pelegri
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Rachel
full_name: Warga, Rachel
last_name: Warga
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Hammerschmidt M, Pelegri F, Mullins M, et al. Dino and Mercedes, two genes
regulating dorsal development in the zebrafish embryo. Development. 1996;123(1):95-102.
doi:10.1242/dev.123.1.95
apa: Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato,
M., … Nüsslein Volhard, C. (1996). Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. Company of Biologists.
https://doi.org/10.1242/dev.123.1.95
chicago: Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane,
Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes,
Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” Development.
Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.95.
ieee: M. Hammerschmidt et al., “Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo,” Development, vol. 123, no. 1. Company
of Biologists, pp. 95–102, 1996.
ista: Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand
M, Furutani Seiki M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J,
Warga R, Nüsslein Volhard C. 1996. Dino and Mercedes, two genes regulating dorsal
development in the zebrafish embryo. Development. 123(1), 95–102.
mla: Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal
Development in the Zebrafish Embryo.” Development, vol. 123, no. 1, Company
of Biologists, 1996, pp. 95–102, doi:10.1242/dev.123.1.95.
short: M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato,
M. Brand, M. Furutani Seiki, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh,
J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T15:10:34Z
day: '01'
doi: 10.1242/dev.123.1.95
extern: '1'
external_id:
pmid:
- '9007232'
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 95 - 102
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1907'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dino and Mercedes, two genes regulating dorsal development in the zebrafish
embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4212'
abstract:
- lang: eng
text: In a large-scale screen, we isolated mutants displaying a specific visible
phenotype in embryos or early larvae of the zebrafish, Danio rerio. Males were
mutagenized with ethylnitrosourea (ENU) and F-2 families of single pair matings
between sibling F-l fish, heterozygous for a mutagenized genome, were raised.
Egg lays were obtained from several crosses between F-2 siblings, resulting in
scoring of 3857 mutagenized genomes. F-3 progeny were scored at the second, third
and sixth day of development, using a stereomicroscope. In a subsequent screen,
fixed embryos were analyzed for correct retinotectal projection. A total of 4264
mutants were identified. Two thirds of the mutants displaying rather general abnormalities
were eventually discarded. We kept and characterized 1163 mutants. In complementation
crosses performed between mutants with similar phenotypes, 894 mutants have been
assigned to 372 genes. The average allele frequency is 2.4. We identified genes
involved in early development, notochord, brain, spinal cord, somites, muscles,
heart, circulation, blood, skin, fin, eye, otic vesicle, jaw and branchial arches,
pigment pattern, pigment formation, gut, liver, motility and touch response. Our
collection contains alleles of almost all previously described zebrafish mutants.
From the allele frequencies and other considerations we estimate that the 372
genes defined by the mutants probably represent more than half of all genes that
could have been discovered using the criteria of our screen. Here we give an overview
of the spectrum of mutant phenotypes obtained, and discuss the limits and the
potentials of a genetic saturation screen in the zebrafish.
acknowledgement: "This work was a collaborative effort in which a large number of
people participated during all or part of the three years of raising the families,
screening and evaluation of the mutants. We thank Rachel Warga, Tatjana Piotrowski,
Francisco Pelegri, Karin Rossnagel and Hans-Martin Maischein for collaboration at
the beginning and the end of the screening and evaluation periods respectively;
Hans-Georg Frohnhöfer for fish health care and for establishing the Tübingen zebrafish
stockcenter; and Wolfgang Driever, Marc Fishman and collaborators, for sharing unpublished
results. We enjoyed the visits of Alison Brownlie, Jau-Nian Chen, Nancy Hopkins,
Corinne Houart, Shuo Lin, David Ransom, Thomas Schilling, Tanya Whitfield and Catherine
Willet, who participated in the analysis of individual mutant classes. We also want
to thank many undergraduate students from the Tübingen University for conscientious
and efficient help in the maintenance and identification of fish, and Torsten Trowe,
Rolf Karlstrom, Barbara Grunwald and Friedrich Bonhoeffer for pleasant and interesting
conversations and collaborations. We thank the staff of our workshop for patience,
\r\n Inventiveness and a very large number of fish containers. We thank Herwig Baier,
Robert Geisler, Darren Gilmour,\r\nNancy Hopkins, Suresh Jesuthasan, Gerd Jürgens,
Francisco Pelegri, Siegfried Roth, Stefan Schulte-Merker, Ralf Sommer, Daniel St
Johnston and Tanya Whitfield, for many helpful suggestions on the manuscript; Robert
Geisler for invaluable help with computers, cameras and colour printers, and the
Tübingen fly group for interest, endless patience and support."
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Elisabeth
full_name: Vogelsang, Elisabeth
last_name: Vogelsang
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Ursula
full_name: Schach, Ursula
last_name: Schach
- first_name: Cosima
full_name: Fabian, Cosima
last_name: Fabian
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Haffter P, Granato M, Brand M, et al. The identification of genes with unique
and essential functions in the development of the zebrafish, Danio rerio. Development.
1996;123(1):1-36. doi:10.1242/dev.123.1.1
apa: Haffter, P., Granato, M., Brand, M., Mullins, M., Hammerschmidt, M., Kane,
D., … Nüsslein Volhard, C. (1996). The identification of genes with unique and
essential functions in the development of the zebrafish, Danio rerio. Development.
Company of Biologists. https://doi.org/10.1242/dev.123.1.1
chicago: Haffter, Pascal, Michael Granato, Michael Brand, Mary Mullins, Matthias
Hammerschmidt, Donald Kane, Jörg Odenthal, et al. “The Identification of Genes
with Unique and Essential Functions in the Development of the Zebrafish, Danio
Rerio.” Development. Company of Biologists, 1996. https://doi.org/10.1242/dev.123.1.1 .
ieee: P. Haffter et al., “The identification of genes with unique and essential
functions in the development of the zebrafish, Danio rerio,” Development,
vol. 123, no. 1. Company of Biologists, pp. 1–36, 1996.
ista: Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, Odenthal
J, Van Eeden F, Jiang Y, Heisenberg C-PJ, Kelsh R, Furutani Seiki M, Vogelsang
E, Beuchle D, Schach U, Fabian C, Nüsslein Volhard C. 1996. The identification
of genes with unique and essential functions in the development of the zebrafish,
Danio rerio. Development. 123(1), 1–36.
mla: Haffter, Pascal, et al. “The Identification of Genes with Unique and Essential
Functions in the Development of the Zebrafish, Danio Rerio.” Development,
vol. 123, no. 1, Company of Biologists, 1996, pp. 1–36, doi:10.1242/dev.123.1.1 .
short: P. Haffter, M. Granato, M. Brand, M. Mullins, M. Hammerschmidt, D. Kane,
J. Odenthal, F. Van Eeden, Y. Jiang, C.-P.J. Heisenberg, R. Kelsh, M. Furutani
Seiki, E. Vogelsang, D. Beuchle, U. Schach, C. Fabian, C. Nüsslein Volhard, Development
123 (1996) 1–36.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:41:37Z
day: '01'
doi: '10.1242/dev.123.1.1 '
extern: '1'
external_id:
pmid:
- '9007226 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 1 - 36
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The identification of genes with unique and essential functions in the development
of the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...
---
_id: '4213'
abstract:
- lang: eng
text: 'Forty zebrafish mutants with localized or general neural degeneration are
described. The onset and duration of degeneration and the distribution of ectopically
dying cells are specific characteristics of each mutant, Mutants are classified
into four groups by these parameters. Class I: late focal neural degeneration
mutants, These 18 mutants have restricted cell death mainly in the tectum and
the dorsal hindbrain after 36 hours, The degeneration does not spread and disappears
at later stages of development. Class LI: early focal neural degeneration mutants.
Ten mutants in this class exhibit transient restricted degeneration affecting
mainly the diencephalon, the hindbrain and the spinal cord at 20 hours, The midbrain
is less affected. The degeneration shifts to the dorsal diencephalon and the tectum
at 36 hours. Class III: late spreading neural degeneration mutants. The 8 mutants
in this class display a degeneration that is first seen in the tectum and subsequently
spreads throughout the nervous system from 36 hours on. Class IV: early general
neural degeneration mutants, This class of four mutants already shows overall
cell degeneration in the nervous system at the 15-somite stage. Three of the class
I mutants show a change in the pattern of gene expression in the anlage of a brain
structure prior to the onset of degeneration. These results suggest that focal
cell death may be a useful clue for the detection of early patterning defects
of the vertebrate nervous system in regions devoid of visible landmarks.'
acknowledgement: We are grateful to Rachel Warga, Tatijana Piotrowski, Francisco Pelegri
and Tomas Schilling for sharing unpublished results. We thank Heinz Schwarz for
histological sections and Eric Weinberg, Monte Westerfield, Stephen Wilson and Hitoshi
Okamoto for in situprobes. We also thank Nancy Hopkins, Francisco Pelegri and Stefan
Schulte-Merker for helpful suggestions on the manuscript, and Raymond Lamos for
technical support.
article_processing_charge: No
article_type: original
author:
- first_name: Makoto
full_name: Furutani Seiki, Makoto
last_name: Furutani Seiki
- first_name: Yunjin
full_name: Jiang, Yunjin
last_name: Jiang
- first_name: Michael
full_name: Brand, Michael
last_name: Brand
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Corinne
full_name: Houart, Corinne
last_name: Houart
- first_name: Dirk
full_name: Beuchle, Dirk
last_name: Beuchle
- first_name: Fredericus
full_name: Van Eeden, Fredericus
last_name: Van Eeden
- first_name: Michael
full_name: Granato, Michael
last_name: Granato
- first_name: Pascal
full_name: Haffter, Pascal
last_name: Haffter
- first_name: Matthias
full_name: Hammerschmidt, Matthias
last_name: Hammerschmidt
- first_name: Donald
full_name: Kane, Donald
last_name: Kane
- first_name: Robert
full_name: Kelsh, Robert
last_name: Kelsh
- first_name: Mary
full_name: Mullins, Mary
last_name: Mullins
- first_name: Jörg
full_name: Odenthal, Jörg
last_name: Odenthal
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Furutani Seiki M, Jiang Y, Brand M, et al. Neural degeneration mutants in the
zebrafish, Danio rerio. Development. 1996;123(1):229-239. doi:10.1242/dev.123.1.229
apa: Furutani Seiki, M., Jiang, Y., Brand, M., Heisenberg, C.-P. J., Houart, C.,
Beuchle, D., … Nüsslein Volhard, C. (1996). Neural degeneration mutants in the
zebrafish, Danio rerio. Development. Company of Biologists. https://doi.org/10.1242/dev.123.1.229
chicago: Furutani Seiki, Makoto, Yunjin Jiang, Michael Brand, Carl-Philipp J Heisenberg,
Corinne Houart, Dirk Beuchle, Fredericus Van Eeden, et al. “Neural Degeneration
Mutants in the Zebrafish, Danio Rerio.” Development. Company of Biologists,
1996. https://doi.org/10.1242/dev.123.1.229
.
ieee: M. Furutani Seiki et al., “Neural degeneration mutants in the zebrafish,
Danio rerio,” Development, vol. 123, no. 1. Company of Biologists, pp.
229–239, 1996.
ista: Furutani Seiki M, Jiang Y, Brand M, Heisenberg C-PJ, Houart C, Beuchle D,
Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M,
Odenthal J, Nüsslein Volhard C. 1996. Neural degeneration mutants in the zebrafish,
Danio rerio. Development. 123(1), 229–239.
mla: Furutani Seiki, Makoto, et al. “Neural Degeneration Mutants in the Zebrafish,
Danio Rerio.” Development, vol. 123, no. 1, Company of Biologists, 1996,
pp. 229–39, doi:10.1242/dev.123.1.229
.
short: M. Furutani Seiki, Y. Jiang, M. Brand, C.-P.J. Heisenberg, C. Houart, D.
Beuchle, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh,
M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 229–239.
date_created: 2018-12-11T12:07:37Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-04T14:02:39Z
day: '01'
doi: '10.1242/dev.123.1.229 '
extern: '1'
external_id:
pmid:
- '9007243 '
intvolume: ' 123'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 229 - 239
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1903'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neural degeneration mutants in the zebrafish, Danio rerio
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 123
year: '1996'
...