---
_id: '4285'
abstract:
- lang: eng
text: One of the oldest hypotheses for the advantage of recombination is that recombination
allo rvs beneficial mutations that arise in different individuals to be placed
together on the same chromosome. Unless recombination occurs, one of the beneficial
alleles is doomed to extinction, slowing the rate at which adaptive mutations
are incorporated within a population. We model the effects of a modifier of recombination
on the fixation probability of beneficial mutations when beneficial alleles are
segregating at other loci. We find that modifier alleles that increase recombination
do increase the fixation probability of beneficial mutants and subsequently hitchhike
along as the mutants rise in frequency. The strength of selection favoring a modifier
that increases recombination is proportional to lambda(2)S delta r/r when linkage
is tight and lambda(2)S(3) delta r/N when linkage is loose, where lambda is the
beneficial mutation rate per genome per generation throughout a population of
size N, S is the average mutant effect, r is the average recombination rate, and
delta ris the amount that recombination is modified. We conclude that selection
for recombination will be substantial only if there is tight linkage within the
genome or if many loci are subject to directional selection as during periods
of rapid evolutionary change.
article_processing_charge: No
article_type: original
author:
- first_name: Sarah
full_name: Otto, Sarah
last_name: Otto
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Otto S, Barton NH. The evolution of recombination: Removing the limits to
natural selection. Genetics. 1997;147(2):879-906. doi:10.1093/genetics/147.2.879'
apa: 'Otto, S., & Barton, N. H. (1997). The evolution of recombination: Removing
the limits to natural selection. Genetics. Genetics Society of America.
https://doi.org/10.1093/genetics/147.2.879'
chicago: 'Otto, Sarah, and Nicholas H Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics. Genetics Society of America,
1997. https://doi.org/10.1093/genetics/147.2.879.'
ieee: 'S. Otto and N. H. Barton, “The evolution of recombination: Removing the limits
to natural selection,” Genetics, vol. 147, no. 2. Genetics Society of America,
pp. 879–906, 1997.'
ista: 'Otto S, Barton NH. 1997. The evolution of recombination: Removing the limits
to natural selection. Genetics. 147(2), 879–906.'
mla: 'Otto, Sarah, and Nicholas H. Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics, vol. 147, no. 2, Genetics Society
of America, 1997, pp. 879–906, doi:10.1093/genetics/147.2.879.'
short: S. Otto, N.H. Barton, Genetics 147 (1997) 879–906.
date_created: 2018-12-11T12:08:02Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-18T11:36:10Z
day: '01'
doi: 10.1093/genetics/147.2.879
extern: '1'
external_id:
pmid:
- '9335621'
intvolume: ' 147'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/147/2/879/6054161
month: '10'
oa: 1
oa_version: Published Version
page: 879 - 906
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1796'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The evolution of recombination: Removing the limits to natural selection'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 147
year: '1997'
...
---
_id: '4286'
abstract:
- lang: eng
text: A local barrier to gene flow will delay the spread of an advantageous allele.
Exact calculations for the deterministic case show that an allele that is favorable
when rare is delayed very little even by a strong barrier; its spread is allowed
by a time proportional to log((B/σ)√2S)/S, where B is the barrier strength, σ
the dispersal range, and fitnesses are 1:1 + S:1 + 2S. However, when there is
selection against heterozytes, such that the allele cannot increase from low frequency,
a barrier can cause a much greater delay. If gene flow is reduced below a critical
value, spread is entirely prevented. Stochastic simulations show that with additive
selection, random drift slows down the spread of the allele, below the deterministic
speed of σ√2S. The delay to the advance of an advantageous allele caused by a
strong barrier can be substantially increased by random drift and increases with
B/(2Sρσ2) in a one-dimensional habitat of density ρ. However, with selection against
heterozygotes, drift can facilitate the spread and can free an allele that would
otherwise be trapped indefinitely by a strong barrier. We discuss the implications
of these results for the evolution of chromosome rearrangements.
acknowledgement: We are specially grateful to H. C. HAUFFE for allowing us to present
her unpublished data. B. NURNBERGER, J. B. SEARLE, H. C. HAUFFE, S. BAIRD, L. KRUUK
and two anonymous referees gave constructive comments on the manuscript. The work
was supported by the European Union (Human Capital and Mobility Contract No. RB4050PL922765.
article_processing_charge: No
article_type: original
author:
- first_name: Jaroslav
full_name: Piálek, Jaroslav
last_name: Piálek
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Piálek J, Barton NH. The spread of an advantageous allele across a barrier:
the effects of random drift and selection against heterozygotes. Genetics.
1997;145(2):493-504. doi:10.1093/genetics/145.2.493'
apa: 'Piálek, J., & Barton, N. H. (1997). The spread of an advantageous allele
across a barrier: the effects of random drift and selection against heterozygotes.
Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/145.2.493'
chicago: 'Piálek, Jaroslav, and Nicholas H Barton. “The Spread of an Advantageous
Allele across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics. Genetics Society of America, 1997. https://doi.org/10.1093/genetics/145.2.493.'
ieee: 'J. Piálek and N. H. Barton, “The spread of an advantageous allele across
a barrier: the effects of random drift and selection against heterozygotes,” Genetics,
vol. 145, no. 2. Genetics Society of America, pp. 493–504, 1997.'
ista: 'Piálek J, Barton NH. 1997. The spread of an advantageous allele across a
barrier: the effects of random drift and selection against heterozygotes. Genetics.
145(2), 493–504.'
mla: 'Piálek, Jaroslav, and Nicholas H. Barton. “The Spread of an Advantageous Allele
across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics, vol. 145, no. 2, Genetics Society of America, 1997, pp. 493–504,
doi:10.1093/genetics/145.2.493.'
short: J. Piálek, N.H. Barton, Genetics 145 (1997) 493–504.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-01T00:00:00Z
date_updated: 2022-08-18T12:34:37Z
day: '01'
doi: 10.1093/genetics/145.2.493
extern: '1'
external_id:
pmid:
- '9071602'
intvolume: ' 145'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/145/2/493/6018085
month: '02'
oa: 1
oa_version: Published Version
page: 493 - 504
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1797'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The spread of an advantageous allele across a barrier: the effects of random
drift and selection against heterozygotes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 145
year: '1997'
...
---
_id: '4287'
abstract:
- lang: eng
text: 'We evaluate Sewall Wright''s three-phase "shifting balance" theory of evolution,
examining both the theoretical issues and the relevant data from nature and the
laboratory. We conclude that while phases I and II of Wright''s theory (the movement
of populations from one "adaptive peak" to another via drift and selection) can
occur under some conditions, genetic drift is often unnecessary for movement between
peaks. Phase III of the shifting balance, in which adaptations spread from particular
populations to the entire species, faces two major theoretical obstacles: (1)
unlike adaptations favored by simple directional selection, adaptations whose
fixation requires some genetic drift are often prevented from spreading by barriers
to gene flow; and (2) it is difficult to assemble complex adaptations whose constituent
parts arise via peak shifts in different demes. Our review of the data from nature
shows that although there is some evidence for individual phases of the shifting
balance process, there are few empirical observations explained better by Wright''s
three-phase mechanism than by simple mass selection. Similarly, artificial selection
experiments fail to show that selection in subdivided populations produces greater
response than does mass selection in large populations. The complexity of the
shifting balance process and the difficulty of establishing that adaptive valleys
have been crossed by genetic drift make it impossible to test Wright''s claim
that adaptations commonly originate by this process. In view of these problems,
it seems unreasonable to consider the shifting balance process as an important
explanation for the evolution of adaptations. '
acknowledgement: 'We thank the following people for discussion and comments on themanuscript:
S.Barrett,J. Bull, B.Charlesworth, D.Charlesworth, P. DeVries, S.Gavrilets, J. H.Gillespie,
R.K.Grosberg, W.G. Hill, A. A.Hoffmann, M.Kirkpatrick, C.H.Langley, R. C.Lewontin,
J.B. Mallet, M. Noor, L.Nunney, H. A. Orr, T. Prout, M.Slatkin, J.Spofford, W.Stephan,
J. B. Walsh, P. Ward, K. Weber, J. Willis, and M.Zwick. We are especially grateful
to D.J. Futuyma and D.Schemskefor their exhaustive criticism of the manuscript.
Needless to say, not all of these reviewers agree with our ideas. This work was
supported by National Institutes of Health grant GM50355 to JAC, National Science
Foundation grant DEB9527808 to MT, and grants from the Darwin Trust of Edinburgh
and the Biotechnology and Biological Sciences Research Council (GRJI76057,GRIHI09928)
to NHB.'
article_processing_charge: No
article_type: original
author:
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: 'Coyne J, Barton NH, Turelli M. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 1997;51(3):643-671.
doi:10.1111/j.1558-5646.1997.tb03650.x'
apa: 'Coyne, J., Barton, N. H., & Turelli, M. (1997). Perspective: A critique
of Sewall Wright’s shifting balance theory of evolutionight’s shifting balance
theory of evolution. Evolution; International Journal of Organic Evolution.
Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x'
chicago: 'Coyne, Jerry, Nicholas H Barton, and Michael Turelli. “Perspective: A
Critique of Sewall Wright’s Shifting Balance Theory of Evolutionight’s Shifting
Balance Theory of Evolution.” Evolution; International Journal of Organic Evolution.
Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x.'
ieee: 'J. Coyne, N. H. Barton, and M. Turelli, “Perspective: A critique of Sewall
Wright’s shifting balance theory of evolutionight’s shifting balance theory of
evolution,” Evolution; International Journal of Organic Evolution, vol.
51, no. 3. Wiley-Blackwell, pp. 643–671, 1997.'
ista: 'Coyne J, Barton NH, Turelli M. 1997. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 51(3), 643–671.'
mla: 'Coyne, Jerry, et al. “Perspective: A Critique of Sewall Wright’s Shifting
Balance Theory of Evolutionight’s Shifting Balance Theory of Evolution.” Evolution;
International Journal of Organic Evolution, vol. 51, no. 3, Wiley-Blackwell,
1997, pp. 643–71, doi:10.1111/j.1558-5646.1997.tb03650.x.'
short: J. Coyne, N.H. Barton, M. Turelli, Evolution; International Journal of Organic
Evolution 51 (1997) 643–671.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-18T09:48:43Z
day: '01'
doi: 10.1111/j.1558-5646.1997.tb03650.x
extern: '1'
external_id:
pmid:
- '28568586'
intvolume: ' 51'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1997.tb03650.x
month: '06'
oa: 1
oa_version: Published Version
page: 643 - 671
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Perspective: A critique of Sewall Wright''s shifting balance theory of evolutionight''s
shifting balance theory of evolution'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 51
year: '1997'
...
---
_id: '4288'
abstract:
- lang: eng
text: We measured the heterozygous effects on net fitness of a sample of 12 wild-type
third chromosomes in D. melanogaster. Effects on fitness were assessed by competing
the wild-type chromosomes against balancer chromosomes, to prevent the production
of recombinants. The measurements were carried out in the population cage environment
in which the life history had been evolving, in an undisturbed population with
overlapping generations, and replicated measurements were made on each chromosome
to control for confounding effects such as mutation accumulation. We found significant
variation among the wild type chromosomes in their additive genetic effect on
net fitness. The system provides an opportunity to obtain an accurate estimate
of the distribution of heterozygous effects on net fitness, the contribution of
different fitness components including male mating success, and the role of intra-chromosomal
epistasis in fitness variation.
acknowledgement: We thank John Sved for helpful discussions in the planningstages
of the project, Brian Charlesworth, Alexei Kondrashov, Trudy Mackay and Steve Stearns
for commentson the manuscript, SERC, BBSRC, the Darwin Trust andthe Royal Society
for Financial support, and Ms N. Goorneyfor technical assistance
article_processing_charge: No
article_type: original
author:
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Colin
full_name: Semple, Colin
last_name: Semple
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
citation:
ama: Fowler K, Semple C, Barton NH, Partridge L. Genetic variation for total fitness
in Drosophila melanogaster. Proceedings of the Royal Society of London Series
B Biological Sciences. 1997;264(1379):191-199. doi:10.1098/rspb.1997.0027
apa: Fowler, K., Semple, C., Barton, N. H., & Partridge, L. (1997). Genetic
variation for total fitness in Drosophila melanogaster. Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society. https://doi.org/10.1098/rspb.1997.0027
chicago: Fowler, Kevin, Colin Semple, Nicholas H Barton, and Linda Partridge. “Genetic
Variation for Total Fitness in Drosophila Melanogaster.” Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society, 1997.
https://doi.org/10.1098/rspb.1997.0027.
ieee: K. Fowler, C. Semple, N. H. Barton, and L. Partridge, “Genetic variation for
total fitness in Drosophila melanogaster,” Proceedings of the Royal Society
of London Series B Biological Sciences, vol. 264, no. 1379. The Royal Society,
pp. 191–199, 1997.
ista: Fowler K, Semple C, Barton NH, Partridge L. 1997. Genetic variation for total
fitness in Drosophila melanogaster. Proceedings of the Royal Society of London
Series B Biological Sciences. 264(1379), 191–199.
mla: Fowler, Kevin, et al. “Genetic Variation for Total Fitness in Drosophila Melanogaster.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 264, no. 1379, The Royal Society, 1997, pp. 191–99, doi:10.1098/rspb.1997.0027.
short: K. Fowler, C. Semple, N.H. Barton, L. Partridge, Proceedings of the Royal
Society of London Series B Biological Sciences 264 (1997) 191–199.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-22T00:00:00Z
date_updated: 2022-08-18T11:31:58Z
day: '22'
doi: 10.1098/rspb.1997.0027
extern: '1'
external_id:
pmid:
- '9061969'
intvolume: ' 264'
issue: '1379'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1688253/
month: '02'
oa: 1
oa_version: Published Version
page: 191 - 199
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: The Royal Society
publist_id: '1792'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic variation for total fitness in Drosophila melanogaster
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 264
year: '1997'
...
---
_id: '4289'
abstract:
- lang: eng
text: A worldwide survey of polymorphic molecular markers shows that the human population
is genetically homogeneous, in close agreement with evidence from quite different
genes and traits.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Population genetics: A new apportionment of human diversity. Current
Biology. 1997;7(12):757-758. doi:10.1016/S0960-9822(06)00397-6'
apa: 'Barton, N. H. (1997). Population genetics: A new apportionment of human diversity.
Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(06)00397-6'
chicago: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human
Diversity.” Current Biology. Cell Press, 1997. https://doi.org/10.1016/S0960-9822(06)00397-6.'
ieee: 'N. H. Barton, “Population genetics: A new apportionment of human diversity,”
Current Biology, vol. 7, no. 12. Cell Press, pp. 757–758, 1997.'
ista: 'Barton NH. 1997. Population genetics: A new apportionment of human diversity.
Current Biology. 7(12), 757–758.'
mla: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human Diversity.”
Current Biology, vol. 7, no. 12, Cell Press, 1997, pp. 757–58, doi:10.1016/S0960-9822(06)00397-6.'
short: N.H. Barton, Current Biology 7 (1997) 757–758.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2022-08-17T13:07:08Z
day: '01'
doi: 10.1016/S0960-9822(06)00397-6
extern: '1'
intvolume: ' 7'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982206003976?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 757 - 758
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1788'
quality_controlled: '1'
status: public
title: 'Population genetics: A new apportionment of human diversity'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '4290'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Natural hybridization and evolution. Genetical Research.
1997;70(2):178-180.
apa: Barton, N. H. (1997). Natural hybridization and evolution. Genetical Research.
Cambridge University Press.
chicago: Barton, Nicholas H. “Natural Hybridization and Evolution.” Genetical
Research. Cambridge University Press, 1997.
ieee: N. H. Barton, “Natural hybridization and evolution,” Genetical Research,
vol. 70, no. 2. Cambridge University Press, pp. 178–180, 1997.
ista: Barton NH. 1997. Natural hybridization and evolution. Genetical Research.
70(2), 178–180.
mla: Barton, Nicholas H. “Natural Hybridization and Evolution.” Genetical Research,
vol. 70, no. 2, Cambridge University Press, 1997, pp. 178–80.
short: N.H. Barton, Genetical Research 70 (1997) 178–180.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-17T14:10:20Z
day: '01'
extern: '1'
intvolume: ' 70'
issue: '2'
language:
- iso: eng
month: '10'
oa_version: None
page: 178 - 180
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1789'
status: public
title: Natural hybridization and evolution
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1997'
...
---
_id: '4291'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. The ecological detective: Confronting models with data. Genetical
Research. 1997;70(2):180-181.'
apa: 'Barton, N. H. (1997). The ecological detective: Confronting models with data.
Genetical Research. Cambridge University Press.'
chicago: 'Barton, Nicholas H. “The Ecological Detective: Confronting Models with
Data.” Genetical Research. Cambridge University Press, 1997.'
ieee: 'N. H. Barton, “The ecological detective: Confronting models with data,” Genetical
Research, vol. 70, no. 2. Cambridge University Press, pp. 180–181, 1997.'
ista: 'Barton NH. 1997. The ecological detective: Confronting models with data.
Genetical Research. 70(2), 180–181.'
mla: 'Barton, Nicholas H. “The Ecological Detective: Confronting Models with Data.”
Genetical Research, vol. 70, no. 2, Cambridge University Press, 1997, pp.
180–81.'
short: N.H. Barton, Genetical Research 70 (1997) 180–181.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-18T09:36:25Z
day: '01'
extern: '1'
intvolume: ' 70'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/ecological-detective-confronting-models-with-data-by-ray-hilborn-and-marc-mangel-princeton-university-press-1997-315xvii-pages-price-3000-cloth-1695-paper-isbn-0-691-03496-6-0-691-03497-4-pbk/AA6FCD668DFFAEF537C2674ECCFC8966
month: '10'
oa_version: None
page: 180 - 181
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1790'
quality_controlled: '1'
status: public
title: 'The ecological detective: Confronting models with data'
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1997'
...
---
_id: '4293'
abstract:
- lang: eng
text: Natural populations differ from the simplest models in ways which can significantly
affect their evolution. Real populations are rarely all of the same size; the
rates of migration into and out of populations vary in space and time; some populations
go extinct, and new ones are established, while all populations fluctuate in size.
Furthermore, the genetic properties of real species are not like those assumed
in simple models. Alleles are exposed to a wide variety of selection mutation
rarely creates novel genotypes with each mutation event, generations overlap,
and environments vary from place to place. Evolution in a metapopulation can be
substantially different from the predictions of single-population models and,
indeed, very different from the simplest models of subdivided species.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Whitlock, Michael
last_name: Whitlock
citation:
ama: 'Barton NH, Whitlock M. The evolution of metapopulations. In: Hanski I, Gilpin
ME, eds. Metapopulation Biology. Academic Press; 1997:183-210. doi:10.1016/B978-012323445-2/50012-2'
apa: Barton, N. H., & Whitlock, M. (1997). The evolution of metapopulations.
In I. Hanski & M. E. Gilpin (Eds.), Metapopulation Biology (pp. 183–210).
Academic Press. https://doi.org/10.1016/B978-012323445-2/50012-2
chicago: Barton, Nicholas H, and Michael Whitlock. “The Evolution of Metapopulations.”
In Metapopulation Biology, edited by Illka Hanski and Michael E. Gilpin,
183–210. Academic Press, 1997. https://doi.org/10.1016/B978-012323445-2/50012-2.
ieee: N. H. Barton and M. Whitlock, “The evolution of metapopulations,” in Metapopulation
Biology, I. Hanski and M. E. Gilpin, Eds. Academic Press, 1997, pp. 183–210.
ista: 'Barton NH, Whitlock M. 1997.The evolution of metapopulations. In: Metapopulation
Biology. , 183–210.'
mla: Barton, Nicholas H., and Michael Whitlock. “The Evolution of Metapopulations.”
Metapopulation Biology, edited by Illka Hanski and Michael E. Gilpin, Academic
Press, 1997, pp. 183–210, doi:10.1016/B978-012323445-2/50012-2.
short: N.H. Barton, M. Whitlock, in:, I. Hanski, M.E. Gilpin (Eds.), Metapopulation
Biology, Academic Press, 1997, pp. 183–210.
date_created: 2018-12-11T12:08:05Z
date_published: 1997-03-12T00:00:00Z
date_updated: 2022-08-17T12:47:42Z
day: '12'
doi: 10.1016/B978-012323445-2/50012-2
editor:
- first_name: Illka
full_name: Hanski, Illka
last_name: Hanski
- first_name: Michael E.
full_name: Gilpin, Michael E.
last_name: Gilpin
extern: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 183 - 210
publication: Metapopulation Biology
publication_identifier:
isbn:
- '9780123234452'
publication_status: published
publisher: Academic Press
publist_id: '1782'
quality_controlled: '1'
status: public
title: The evolution of metapopulations
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1997'
...
---
_id: '4438'
abstract:
- lang: eng
text: "In temporal-logic model checking, we verify the correctness of a program
with respect to a desired behavior by checking whether a structure that models
the program satisfies a temporal-logic formula that specifies the behavior. The
model-checking problem for the branching-time temporal logic CTL can be solved
in linear running time, and model-checking tools for CTL are used successfully
in industrial applications. The development of programs that must meet rigid real-time
constraints has brought with it a need for real-time temporal logics that enable
quantitative reference to time. Early research on real-time temporal logics uses
the discrete domain of the integers to model time. Present research on real-time
temporal logics focuses on continuous time and uses the dense domain of the reals
to model time. There, model checking becomes significantly more complicated. For
example, the model-checking problem for TCTL, a continuous-time extension of the
logic CTL, is PSPACE-complete.\r\nIn this paper we suggest a reduction from TCTL
model checking to CTL model checking. The contribution of such a reduction is
twofold. Theoretically, while it has long been known that model-checking methods
for untimed temporal logics can be extended quite easily to handle discrete time,
it was not clear whether and how untimed methods can handle the reset quantifier
of TCTL, which resets a realvalued clock. Practically, our reduction enables anyone
who has a tool for CTL model checking to use it for TCTL model checking. The TCTL
model-checking algorithm that follows from our reduction is in PSPACE, matching
the known bound for this problem. In addition, it enjoys the wide distribution
of CTL model-checking tools and the extensive and fruitful research efforts and
heuristics that have been put into these tools."
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: 'Henzinger TA, Kupferman O. From quantity to quality. In: Proceedings of
the 5th International Workshop on Hybrid and Real-Time Systems. Vol 1201.
Springer; 1997:48-62. doi:10.1007/BFb0014712'
apa: 'Henzinger, T. A., & Kupferman, O. (1997). From quantity to quality. In
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems
(Vol. 1201, pp. 48–62). Grenoble, France: Springer. https://doi.org/10.1007/BFb0014712'
chicago: Henzinger, Thomas A, and Orna Kupferman. “From Quantity to Quality.” In
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems,
1201:48–62. Springer, 1997. https://doi.org/10.1007/BFb0014712.
ieee: T. A. Henzinger and O. Kupferman, “From quantity to quality,” in Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems, Grenoble,
France, 1997, vol. 1201, pp. 48–62.
ista: 'Henzinger TA, Kupferman O. 1997. From quantity to quality. Proceedings of
the 5th International Workshop on Hybrid and Real-Time Systems. HART: Hybrid and
Real-Time Systems, LNCS, vol. 1201, 48–62.'
mla: Henzinger, Thomas A., and Orna Kupferman. “From Quantity to Quality.” Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems, vol. 1201,
Springer, 1997, pp. 48–62, doi:10.1007/BFb0014712.
short: T.A. Henzinger, O. Kupferman, in:, Proceedings of the 5th International Workshop
on Hybrid and Real-Time Systems, Springer, 1997, pp. 48–62.
conference:
end_date: 1997-03-28
location: Grenoble, France
name: 'HART: Hybrid and Real-Time Systems'
start_date: 1997-03-26
date_created: 2018-12-11T12:08:51Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T12:29:48Z
day: '01'
doi: 10.1007/BFb0014712
extern: '1'
intvolume: ' 1201'
language:
- iso: eng
month: '01'
oa_version: None
page: 48 - 62
publication: Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems
publication_identifier:
isbn:
- '9783540626008'
publication_status: published
publisher: Springer
publist_id: '291'
quality_controlled: '1'
scopus_import: '1'
status: public
title: From quantity to quality
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1201
year: '1997'
...
---
_id: '4441'
abstract:
- lang: eng
text: Rectangular hybrid automata model digital control programs of analog plant
environments. We study rectangular hybrid automata where the plant state evolves
continuously in real-numbered time, and the controller samples the plant state
and changes the control state discretely, only at the integer points in time.
We prove that rectangular hybrid automata have finite bisimilarity quotients when
all control transitions happen at integer times, even if the constraints on the
derivatives of the variables vary between control states. This is sharply in contrast
with the conventional model where control transitions may happen at any real time,
and already the reachability problem is undecidable. Based on the finite bisimilarity
quotients, we give an exponential algorithm for the symbolic sampling-controller
synthesis of rectangular automata. We show our algorithm to be optimal by proving
the problem to be EXPTIME-hard. We also show that rectangular automata form a
maximal class of systems for which the sampling-controller synthesis problem can
be solved algorithmically.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI contract DAAH-04-96-1-0341, by the ARO
contract DAAL03-91-C-0027 through the MSI at Cornell University, by the ARPA grant
NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
citation:
ama: 'Henzinger TA, Kopke P. Discrete-time control for rectangular hybrid automata.
In: Proceedings of the 24th International Colloquium on Automata, Languages
and Programming. Vol 1256. Springer; 1997:582-593. doi:10.1007/3-540-63165-8_213'
apa: 'Henzinger, T. A., & Kopke, P. (1997). Discrete-time control for rectangular
hybrid automata. In Proceedings of the 24th International Colloquium on Automata,
Languages and Programming (Vol. 1256, pp. 582–593). Bologna, Italy: Springer.
https://doi.org/10.1007/3-540-63165-8_213'
chicago: Henzinger, Thomas A, and Peter Kopke. “Discrete-Time Control for Rectangular
Hybrid Automata.” In Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, 1256:582–93. Springer, 1997. https://doi.org/10.1007/3-540-63165-8_213.
ieee: T. A. Henzinger and P. Kopke, “Discrete-time control for rectangular hybrid
automata,” in Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, Bologna, Italy, 1997, vol. 1256, pp. 582–593.
ista: 'Henzinger TA, Kopke P. 1997. Discrete-time control for rectangular hybrid
automata. Proceedings of the 24th International Colloquium on Automata, Languages
and Programming. ICALP: Automata, Languages and Programming, LNCS, vol. 1256,
582–593.'
mla: Henzinger, Thomas A., and Peter Kopke. “Discrete-Time Control for Rectangular
Hybrid Automata.” Proceedings of the 24th International Colloquium on Automata,
Languages and Programming, vol. 1256, Springer, 1997, pp. 582–93, doi:10.1007/3-540-63165-8_213.
short: T.A. Henzinger, P. Kopke, in:, Proceedings of the 24th International Colloquium
on Automata, Languages and Programming, Springer, 1997, pp. 582–593.
conference:
end_date: 1997-07-11
location: Bologna, Italy
name: 'ICALP: Automata, Languages and Programming'
start_date: 1997-07-07
date_created: 2018-12-11T12:08:52Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T12:04:15Z
day: '01'
doi: 10.1007/3-540-63165-8_213
extern: '1'
intvolume: ' 1256'
language:
- iso: eng
month: '01'
oa_version: None
page: 582 - 593
publication: Proceedings of the 24th International Colloquium on Automata, Languages
and Programming
publication_identifier:
isbn:
- '9783540631651'
publication_status: published
publisher: Springer
publist_id: '289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discrete-time control for rectangular hybrid automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1256
year: '1997'
...
---
_id: '4493'
abstract:
- lang: eng
text: A hybrid system is a dynamical system whose behavior exhibits both discrete
and continuous change. A hybrid automaton is a mathematical model for hybrid systems,
which combines, in a single formalism, automaton transitions for capturing discrete
change with differential equations for capturing continuous change. HyTech is
a symbolic model checker for linear hybrid automata, a subclass of hybrid automata
that can be analyzed automatically by computing with polyhedral state sets. A
key feature of HyTech is its ability to perform parametric analysis, i.e., to
determine the values of design parameters for which a linear hybrid automaton
satisfies a temporal-logic requirement.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
the NSF CAREER award CCR-501708, NSF grant CCR-9504469, AFOSR contract F49620-93-1-0056,
ARO MURI grant DAAH-04-96-1-0341, ARPA grant AG2-892, and SRC contract 95-DC-324.036.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Ho P, Wong Toi H. HyTech: A model checker for hybrid systems.
Software Tools For Technology Transfer. 1997;1(1-2):110-122. doi:10.1007/s100090050008'
apa: 'Henzinger, T. A., Ho, P., & Wong Toi, H. (1997). HyTech: A model checker
for hybrid systems. Software Tools For Technology Transfer. Springer. https://doi.org/10.1007/s100090050008'
chicago: 'Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “HyTech: A Model Checker
for Hybrid Systems.” Software Tools For Technology Transfer. Springer,
1997. https://doi.org/10.1007/s100090050008.'
ieee: 'T. A. Henzinger, P. Ho, and H. Wong Toi, “HyTech: A model checker for hybrid
systems,” Software Tools For Technology Transfer, vol. 1, no. 1–2. Springer,
pp. 110–122, 1997.'
ista: 'Henzinger TA, Ho P, Wong Toi H. 1997. HyTech: A model checker for hybrid
systems. Software Tools For Technology Transfer. 1(1–2), 110–122.'
mla: 'Henzinger, Thomas A., et al. “HyTech: A Model Checker for Hybrid Systems.”
Software Tools For Technology Transfer, vol. 1, no. 1–2, Springer, 1997,
pp. 110–22, doi:10.1007/s100090050008.'
short: T.A. Henzinger, P. Ho, H. Wong Toi, Software Tools For Technology Transfer
1 (1997) 110–122.
date_created: 2018-12-11T12:09:08Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T11:14:15Z
day: '01'
doi: 10.1007/s100090050008
extern: '1'
intvolume: ' 1'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 110 - 122
publication: Software Tools For Technology Transfer
publication_identifier:
issn:
- 1433-2779
publication_status: published
publisher: Springer
publist_id: '236'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'HyTech: A model checker for hybrid systems'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1997'
...
---
_id: '4494'
abstract:
- lang: eng
text: A hybrid system consists of a collection of digital programs that interact
with each other and with an analog environment. Examples of hybrid systems include
medical equipment, manufacturing controllers, automotive controllers, and robots.
The formal analysis of the mixed digital-analog nature of these systems requires
a model that incorporates the discrete behavior of computer programs with the
continuous behavior of environment variables, such as temperature and pressure.
Hybrid automata capture both types of behavior by combining finite automata with
differential inclusions (i.e. differential inequalities). HyTech is a symbolic
model checker for linear hybrid automata, an expressive, yet automatically analyzable,
subclass of hybrid automata. A key feature of HyTech is its ability to perform
parametric analysis, i.e. to determine the values of design parameters for which
a linear hybrid automaton satisfies a temporal requirement.
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Pei
full_name: Ho, Pei
last_name: Ho
- first_name: Howard
full_name: Wong Toi, Howard
last_name: Wong Toi
citation:
ama: 'Henzinger TA, Ho P, Wong Toi H. HyTech: A model checker for hybrid systems.
In: Vol 1254. Springer; 1997:460-463. doi:10.1007/3-540-63166-6_48'
apa: 'Henzinger, T. A., Ho, P., & Wong Toi, H. (1997). HyTech: A model checker
for hybrid systems (Vol. 1254, pp. 460–463). Presented at the CAV: Computer Aided
Verification, Haifa, Israel: Springer. https://doi.org/10.1007/3-540-63166-6_48'
chicago: 'Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “HyTech: A Model Checker
for Hybrid Systems,” 1254:460–63. Springer, 1997. https://doi.org/10.1007/3-540-63166-6_48.'
ieee: 'T. A. Henzinger, P. Ho, and H. Wong Toi, “HyTech: A model checker for hybrid
systems,” presented at the CAV: Computer Aided Verification, Haifa, Israel, 1997,
vol. 1254, pp. 460–463.'
ista: 'Henzinger TA, Ho P, Wong Toi H. 1997. HyTech: A model checker for hybrid
systems. CAV: Computer Aided Verification, LNCS, vol. 1254, 460–463.'
mla: 'Henzinger, Thomas A., et al. HyTech: A Model Checker for Hybrid Systems.
Vol. 1254, Springer, 1997, pp. 460–63, doi:10.1007/3-540-63166-6_48.'
short: T.A. Henzinger, P. Ho, H. Wong Toi, in:, Springer, 1997, pp. 460–463.
conference:
end_date: 1997-06-25
location: Haifa, Israel
name: 'CAV: Computer Aided Verification'
start_date: 1997-06-22
date_created: 2018-12-11T12:09:08Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T11:06:13Z
day: '01'
doi: 10.1007/3-540-63166-6_48
extern: '1'
intvolume: ' 1254'
language:
- iso: eng
month: '01'
oa_version: None
page: 460 - 463
publication_identifier:
isbn:
- '9783540631668'
publication_status: published
publisher: Springer
publist_id: '235'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'HyTech: A model checker for hybrid systems'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1254
year: '1997'
...
---
_id: '4496'
abstract:
- lang: eng
text: 'The simulation preorder for labeled transition systems is defined locally
as a game that relates states with their immediate successor states. Liveness
assumptions about transition systems are typically modeled using fairness constraints.
Existing notions of simulation for fair transition systems, however, are not local,
and as a result, many appealing properties of the simulation preorder are lost.
We extend the local definition of simulation to account for fairness: system S
fairly simulates system I iff in the simulation game, there is a strategy that
matches with each fair computation of I a fair computation of S. Our definition
enjoys a fully abstract semantics and has a logical characterization: S fairly
simulates I iff every fair computation tree embedded in the unrolling of I can
be embedded also in the unrolling of S or, equivalently, iff every Fair-AFMC formula
satisfied by I is satisfied also by S (AFMC is the universal fragment of the alternation-free
-calculus). The locality of the definition leads us to a polynomial-time algorithm
for checking fair simulation for finite-state systems with weak and strong fairness
constraints. Finally, fair simulation implies fair trace-containment, and is therefore
useful as an efficientlycomputable local criterion for proving linear-time abstraction
hierarchies.'
acknowledgement: This research was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Henzinger TA, Kupferman O, Rajamani S. Fair simulation. In: Proceedings
of the 8th International Conference on Concurrency Theory. Vol 1243. Springer;
1997:273-287. doi:10.1007/3-540-63141-0_19'
apa: 'Henzinger, T. A., Kupferman, O., & Rajamani, S. (1997). Fair simulation.
In Proceedings of the 8th International Conference on Concurrency Theory
(Vol. 1243, pp. 273–287). Warsaw, Poland: Springer. https://doi.org/10.1007/3-540-63141-0_19'
chicago: Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.”
In Proceedings of the 8th International Conference on Concurrency Theory,
1243:273–87. Springer, 1997. https://doi.org/10.1007/3-540-63141-0_19.
ieee: T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” in Proceedings
of the 8th International Conference on Concurrency Theory, Warsaw, Poland,
1997, vol. 1243, pp. 273–287.
ista: 'Henzinger TA, Kupferman O, Rajamani S. 1997. Fair simulation. Proceedings
of the 8th International Conference on Concurrency Theory. CONCUR: Concurrency
Theory, LNCS, vol. 1243, 273–287.'
mla: Henzinger, Thomas A., et al. “Fair Simulation.” Proceedings of the 8th International
Conference on Concurrency Theory, vol. 1243, Springer, 1997, pp. 273–87, doi:10.1007/3-540-63141-0_19.
short: T.A. Henzinger, O. Kupferman, S. Rajamani, in:, Proceedings of the 8th International
Conference on Concurrency Theory, Springer, 1997, pp. 273–287.
conference:
end_date: 1997-07-04
location: Warsaw, Poland
name: 'CONCUR: Concurrency Theory'
start_date: 1997-07-01
date_created: 2018-12-11T12:09:09Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T09:09:13Z
day: '01'
doi: 10.1007/3-540-63141-0_19
extern: '1'
intvolume: ' 1243'
language:
- iso: eng
month: '01'
oa_version: None
page: 273 - 287
publication: Proceedings of the 8th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540631415'
publication_status: published
publisher: Springer
publist_id: '234'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair simulation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1243
year: '1997'
...
---
_id: '4520'
abstract:
- lang: eng
text: 'We define robust timed automata, which are timed automata that accept all
trajectories robustly: if a robust timed automaton accepts a trajectory, then
it must accept neighboring trajectories also; and if a robust timed automaton
rejects a trajectory, then it must reject neighboring trajectories also. We show
that the emptiness problem for robust timed automata is still decidable, by modifying
the region construction for timed automata. We then show that, like timed automata,
robust timed automata cannot be determinized. This result is somewhat unexpected,
given that in temporal logic, the removal of realtime equality constraints is
known to lead to a decidable theory that is closed under all boolean operations.'
acknowledgement: The first and third author were supported in part by grants from
ARPA and ONR. The second author was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 95-DC-324.036. The third author was also
supported by the NSF.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Vineet
full_name: Gupta, Vineet
last_name: Gupta
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Radha
full_name: Jagadeesan, Radha
last_name: Jagadeesan
citation:
ama: 'Gupta V, Henzinger TA, Jagadeesan R. Robust timed automata. In: Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems. Vol 1201.
Springer; 1997:331-345. doi:10.1007/BFb0014736'
apa: 'Gupta, V., Henzinger, T. A., & Jagadeesan, R. (1997). Robust timed automata.
In Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems
(Vol. 1201, pp. 331–345). Grenoble, France: Springer. https://doi.org/10.1007/BFb0014736'
chicago: Gupta, Vineet, Thomas A Henzinger, and Radha Jagadeesan. “Robust Timed
Automata.” In Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems, 1201:331–45. Springer, 1997. https://doi.org/10.1007/BFb0014736.
ieee: V. Gupta, T. A. Henzinger, and R. Jagadeesan, “Robust timed automata,” in
Proceedings of the 5th International Workshop on Hybrid and Real-Time Systems,
Grenoble, France, 1997, vol. 1201, pp. 331–345.
ista: 'Gupta V, Henzinger TA, Jagadeesan R. 1997. Robust timed automata. Proceedings
of the 5th International Workshop on Hybrid and Real-Time Systems. HART: Hybrid
and Real-Time Systems, LNCS, vol. 1201, 331–345.'
mla: Gupta, Vineet, et al. “Robust Timed Automata.” Proceedings of the 5th International
Workshop on Hybrid and Real-Time Systems, vol. 1201, Springer, 1997, pp. 331–45,
doi:10.1007/BFb0014736.
short: V. Gupta, T.A. Henzinger, R. Jagadeesan, in:, Proceedings of the 5th International
Workshop on Hybrid and Real-Time Systems, Springer, 1997, pp. 331–345.
conference:
end_date: 1997-03-28
location: Grenoble, France
name: 'HART: Hybrid and Real-Time Systems'
start_date: 1997-03-26
date_created: 2018-12-11T12:09:17Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-17T09:04:39Z
day: '01'
doi: 10.1007/BFb0014736
extern: '1'
intvolume: ' 1201'
language:
- iso: eng
month: '01'
oa_version: None
page: 331 - 345
publication: Proceedings of the 5th International Workshop on Hybrid and Real-Time
Systems
publication_identifier:
isbn:
- '9783540626008'
publication_status: published
publisher: Springer
publist_id: '207'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Robust timed automata
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1201
year: '1997'
...
---
_id: '2492'
abstract:
- lang: eng
text: The metabotropic glutamate receptor subtypes mGluR2 and mGluR5, which are
thought to be coupled respectively to the inhibitory cyclic adenosine monophosphate
(cAMP) cascade and the phosphatidylinositol hydrolysis/Ca2+ cascade, are known
to be expressed on Golgi cells in the granular layer of the rat cerebellar cortex.
In the present immunohistochemical study with a monoclonal antibody against mGluR2
and a polyclonal antibody for mGluR5, we examined whether or not mGluR2- and mGluR5-like
immunoreactivities were both present in single Golgi cells in the rat cerebellar
cortex. In double immunofluorescence histochemistry, no Golgi cells showed mGluR2-
and mGluR5-like immunoreactivities simultaneously. Of the total number of Golgi
cells immunoreactive for mGluR2 or mGluR5, about 90% were mGluR2-like immunoreactive,
and about 10% were mGluR5-like immunoreactive. Golgi cells with mGluR2-like immunoreactivity
were distributed evenly in the granular layer of all the cerebellar regions, while
those with mGluR5-like immunoreactivity were distributed more frequently in the
I, II, VII-X lobules of the vermis and the copula pyramidis of the hemisphere
than in other cerebellar regions. The results indicate that Golgi cells containing
mGluR2 are segregated from those possessing mGluR5. These two populations of Golgi
cells, each equipped with a different metabolic glutamate receptor coupled to
a different intracellular signal transduction system, may play different roles
in the glutamatergic neuronal circuits in the cerebellar cortex.
acknowledgement: We thank Mr Akira Uesugi for expert photographic assistance. We also
thank Dr Jeremy M. Henley for a critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Metabotropic
glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations
of Golgi cells in the rat cerebellum. Neuroscience. 1996;75(3):815-826.
doi:10.1016/0306-4522(96)00316-8
apa: Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno,
N. (1996). Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in
two non-overlapping populations of Golgi cells in the rat cerebellum. Neuroscience.
Elsevier. https://doi.org/10.1016/0306-4522(96)00316-8
chicago: Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Metabotropic Glutamate Receptors MGluR2 and MGluR5
Are Expressed in Two Non-Overlapping Populations of Golgi Cells in the Rat Cerebellum.”
Neuroscience. Elsevier, 1996. https://doi.org/10.1016/0306-4522(96)00316-8.
ieee: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping
populations of Golgi cells in the rat cerebellum,” Neuroscience, vol. 75,
no. 3. Elsevier, pp. 815–826, 1996.
ista: Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Metabotropic
glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping populations
of Golgi cells in the rat cerebellum. Neuroscience. 75(3), 815–826.
mla: Neki, Akio, et al. “Metabotropic Glutamate Receptors MGluR2 and MGluR5 Are
Expressed in Two Non-Overlapping Populations of Golgi Cells in the Rat Cerebellum.”
Neuroscience, vol. 75, no. 3, Elsevier, 1996, pp. 815–26, doi:10.1016/0306-4522(96)00316-8.
short: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience
75 (1996) 815–826.
date_created: 2018-12-11T11:57:59Z
date_published: 1996-12-01T00:00:00Z
date_updated: 2022-08-12T12:11:03Z
day: '01'
doi: 10.1016/0306-4522(96)00316-8
extern: '1'
external_id:
pmid:
- '8951875'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 815 - 826
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4409'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metabotropic glutamate receptors mGluR2 and mGluR5 are expressed in two non-overlapping
populations of Golgi cells in the rat cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '1996'
...
---
_id: '2562'
abstract:
- lang: eng
text: A monoclonal antibody against a metabotropic glutamate receptor, mGluR2, was
produced by using a glutathione S-transferase (GST) fusion protein containing
an N-terminal sequence of rat mGluR2. Intense mGluR2-like immunoreactivity (mGluR2-LI)
was seen mainly in neuropil of the cerebral cortical regions, hippocampus, olfactory
bulb, some diencephalic nuclei, dorsal cochlear nucleus and cerebellar cortex.
In the cerebellar cortex, mGluR2-LI was seen only in Golgi cells. In Ammon's hem,
mGluR2-LI was marked in the stratum lucidum of CA3 and the stratum lacunosum-moleculare
of CA1-CA3, but not detected in the stratum pyramidale. The results indicate that
mGluR2 is located not only presynaptically but also postsynaptically.
acknowledgement: We are grateful to Mr. Akira Uesugi for photographic help.
article_processing_charge: No
article_type: original
author:
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Pre- and postsynaptic
localization of a metabotropic glutamate receptor, mGluR2, in the rat brain: An
immunohistochemical study with a monoclonal antibody. Neuroscience Letters.
1996;202(3):197-200. doi:10.1016/0304-3940(95)12248-6'
apa: 'Neki, A., Ohishi, H., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno,
N. (1996). Pre- and postsynaptic localization of a metabotropic glutamate receptor,
mGluR2, in the rat brain: An immunohistochemical study with a monoclonal antibody.
Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(95)12248-6'
chicago: 'Neki, Akio, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada
Nakanishi, and Noboru Mizuno. “Pre- and Postsynaptic Localization of a Metabotropic
Glutamate Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with
a Monoclonal Antibody.” Neuroscience Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12248-6.'
ieee: 'A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno,
“Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody,” Neuroscience
Letters, vol. 202, no. 3. Elsevier, pp. 197–200, 1996.'
ista: 'Neki A, Ohishi H, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1996. Pre-
and postsynaptic localization of a metabotropic glutamate receptor, mGluR2, in
the rat brain: An immunohistochemical study with a monoclonal antibody. Neuroscience
Letters. 202(3), 197–200.'
mla: 'Neki, Akio, et al. “Pre- and Postsynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR2, in the Rat Brain: An Immunohistochemical Study with a Monoclonal
Antibody.” Neuroscience Letters, vol. 202, no. 3, Elsevier, 1996, pp. 197–200,
doi:10.1016/0304-3940(95)12248-6.'
short: A. Neki, H. Ohishi, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience
Letters 202 (1996) 197–200.
date_created: 2018-12-11T11:58:24Z
date_published: 1996-01-05T00:00:00Z
date_updated: 2022-08-12T12:04:18Z
day: '05'
doi: 10.1016/0304-3940(95)12248-6
extern: '1'
external_id:
pmid:
- '8848265'
intvolume: ' 202'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 197 - 200
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4335'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Pre- and postsynaptic localization of a metabotropic glutamate receptor, mGluR2,
in the rat brain: An immunohistochemical study with a monoclonal antibody'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 202
year: '1996'
...
---
_id: '2564'
abstract:
- lang: eng
text: The distribution of the neuromedin K receptor (NK3; NKR) in the central nervous
system was investigated in the adult rat by using in situ hybridization and immunohistochemical
techniques. The rabbit anti-NKR antibody was raised against a bacterial fusion
protein containing a C- terminal portion of NKR and affinity purified with a Sepharose
4B column conjugated to the fusion protein. Immunoblot analysis was performed
to test the reactivity and specificity of the antibody. Crude membrane was prepared
from cDNA-transfected Chinese hamster ovary (CHO) cells expressing each of the
rat NKR, substance P receptor (NK1; SPR), and substance K receptor (NK2; SKR)
and from the hypothalamus, cerebral cortex, and cerebellum. Immunoreactive bands
were observed specifically in the NKR-CHO cells, hypothalamus, and cerebral cortex
but not in the SPR- or SKR-CHO cells, nor in the cerebellum. Molecular weights
of the immunoreactive bands ranged from 73 to 89 kDa and from 59 to 83 kDa in
the NKR-CHO cells and tissues, respectively. The distribution of NKR-like immunoreactivity
coincided with that of NKR mRNA. The expression of NKR was indicated on neuronal
cell bodies and dendrites. NKR was found to be expressed intensely or moderately
in neurons in the glomerular and granule cell layers of the main olfactory bulb;
glomerular and mitral cell layers of the accessory olfactory bulb; layers IV and
V of the cerebral neocortex; medial septal nucleus; nucleus of the diagonal band;
bed nucleus of the stria terminalis; globus pallidus; ventral pallidum; paraventricular
nucleus; supraoptic nucleus; zona incerta; dorsal, lateral, and posterior hypothalamic
areas; amygdaloid nuclei; medial habenular nucleus; ventral tegmental area; midbrain
periaqueductal gray; interpeduncular nuclei; substantia nigra pars compacta; linear,
median, dorsal, and pontine raphe nuclei; posteromedial tegmental nucleus; sphenoid
nucleus; nucleus of the solitary tract; intermediate and rostroventrolateral reticular
nuclei; and lamina II of the caudal spinal trigeminal nucleus and spinal dorsal
horn. These findings are discussed in relation to the physiological functions
associated with neuromedin K.
acknowledgement: 'We are grateful for the photographic help of Mr. A. Uesugi and
the support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sozaburo Hayashi, Mizuho Katsurada,
Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda, Hiroshi Matsu- bara, Hiroshi Matsushima, Chisato
Minakuchi, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi,
Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino.
This work was supported in part by Grants-in-Aid for Special Research on Priority
areas 05267104, Scientific Research (B) 05454658, and Scientific Research (C) 06680735
from the Ministry of Education, Science and Culture of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Shigemoto R, Takada M, Ohishi H, Nakanishi S, Mizuno N. Localization
of the neuromedin K receptor (NK3) in the central nervous system of the rat. Journal
of Comparative Neurology. 1996;364(2):290-310. doi:10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
apa: Ding, Y., Shigemoto, R., Takada, M., Ohishi, H., Nakanishi, S., & Mizuno,
N. (1996). Localization of the neuromedin K receptor (NK3) in the central nervous
system of the rat. Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
chicago: Ding, Yu, Ryuichi Shigemoto, Masahiko Takada, Hitoshi Ohishi, Shigetada
Nakanishi, and Noboru Mizuno. “Localization of the Neuromedin K Receptor (NK3)
in the Central Nervous System of the Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1996. https://doi.org/10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0.
ieee: Y. Ding, R. Shigemoto, M. Takada, H. Ohishi, S. Nakanishi, and N. Mizuno,
“Localization of the neuromedin K receptor (NK3) in the central nervous system
of the rat,” Journal of Comparative Neurology, vol. 364, no. 2. Wiley-Blackwell,
pp. 290–310, 1996.
ista: Ding Y, Shigemoto R, Takada M, Ohishi H, Nakanishi S, Mizuno N. 1996. Localization
of the neuromedin K receptor (NK3) in the central nervous system of the rat. Journal
of Comparative Neurology. 364(2), 290–310.
mla: Ding, Yu, et al. “Localization of the Neuromedin K Receptor (NK3) in the Central
Nervous System of the Rat.” Journal of Comparative Neurology, vol. 364,
no. 2, Wiley-Blackwell, 1996, pp. 290–310, doi:10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0.
short: Y. Ding, R. Shigemoto, M. Takada, H. Ohishi, S. Nakanishi, N. Mizuno, Journal
of Comparative Neurology 364 (1996) 290–310.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-01-08T00:00:00Z
date_updated: 2022-08-12T09:48:24Z
day: '08'
doi: 10.1002/(SICI)1096-9861(19960108)364:2<290::AID-CNE8>3.0.CO;2-0
extern: '1'
external_id:
pmid:
- '8788251 '
intvolume: ' 364'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 290 - 310
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4334'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of the neuromedin K receptor (NK3) in the central nervous system
of the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 364
year: '1996'
...
---
_id: '2565'
abstract:
- lang: eng
text: Immunoreactivity for the metabotropic glutamate receptor 7 (mGluR7) and that
for phosphate-activated glutaminase (PAG) were examined in the trigeminal (TG),
dorsal root (DRG), nodose (NG), superior cervical, celiac, and pelvic ganglia
of the rat. Virtually all neuronal cell bodies showed mGluR7-like immunoreactivity
(mGluR7-LI) in these ganglia. On the other hand, PAG-like immunoreactivity (PAG)
was seen in almost all neuronal cell bodies in the TG, DRG and NG, but not in
the other ganglia. Co-existence of mGluR7- and PAG-LI in the TG, DRG and NG was
confirmed by a double-immunofluorescence immunohistochemical method. The results
indicate that virtually all sensory ganglion neurons are glutamatergic and equipped
with mGluR7.
acknowledgement: The authors are grateful for the support of Dr. Kajitaro Morita and
photographic help of Mr. Akira Uesugi. This work was supported in part by Grant-in-Aid
from the Ministry of Education, Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Ohishi H, Kaneko T, et al. Immunohistochemical localization of a metabotropic
glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference
to the presence in glutamatergic ganglion neurons. Neuroscience Letters.
1996;204(1-2):9-12. doi:10.1016/0304-3940(95)12299-0
apa: Li, J., Ohishi, H., Kaneko, T., Shigemoto, R., Neki, A., Nakanishi, S., &
Mizuno, N. (1996). Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/0304-3940(95)12299-0
chicago: Li, Jin, Hitoshi Ohishi, Takeshi Kaneko, Ryuichi Shigemoto, Akio Neki,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of a
Metabotropic Glutamate Receptor, MGluR7, in Ganglion Neurons of the Rat; with
Special Reference to the Presence in Glutamatergic Ganglion Neurons.” Neuroscience
Letters. Elsevier, 1996. https://doi.org/10.1016/0304-3940(95)12299-0.
ieee: J. Li et al., “Immunohistochemical localization of a metabotropic glutamate
receptor, mGluR7, in ganglion neurons of the rat; with special reference to the
presence in glutamatergic ganglion neurons,” Neuroscience Letters, vol.
204, no. 1–2. Elsevier, pp. 9–12, 1996.
ista: Li J, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, Mizuno N. 1996.
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons. Neuroscience Letters. 204(1–2), 9–12.
mla: Li, Jin, et al. “Immunohistochemical Localization of a Metabotropic Glutamate
Receptor, MGluR7, in Ganglion Neurons of the Rat; with Special Reference to the
Presence in Glutamatergic Ganglion Neurons.” Neuroscience Letters, vol.
204, no. 1–2, Elsevier, 1996, pp. 9–12, doi:10.1016/0304-3940(95)12299-0.
short: J. Li, H. Ohishi, T. Kaneko, R. Shigemoto, A. Neki, S. Nakanishi, N. Mizuno,
Neuroscience Letters 204 (1996) 9–12.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-02-02T00:00:00Z
date_updated: 2022-08-12T09:29:03Z
day: '02'
doi: 10.1016/0304-3940(95)12299-0
extern: '1'
external_id:
pmid:
- '8929965 '
intvolume: ' 204'
issue: 1-2
language:
- iso: eng
month: '02'
oa_version: None
page: 9 - 12
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4333'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7,
in ganglion neurons of the rat; with special reference to the presence in glutamatergic
ganglion neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 204
year: '1996'
...
---
_id: '2566'
abstract:
- lang: eng
text: The present study indicated presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in projection neurons of the main olfactory bulb of rat. An
antibody was produced by using a peptide corresponding to C-terminal 23 amino
acids of mouse mGluR8. It was confirmed that the C-terminal 23 amino acids of
rat mGluR8 were the same as those of mouse mGluR8 except for one, and that the
antibody specifically recognized mGluR8 in the rat rhinencephalon. In layer Ia
of the piriform cortex (a target area of projection fibers from the main olfactory
bulb), mGluR8-like immunoreactivity (mGluR8-LI) was reduced after transection
of the lateral olfactory tract, and mGluR8-LI was observed in axon terminals which
were filled with round synaptic vesicles and made asymmetric synapses with dendritic
spines.
acknowledgement: 'We are grateful to Mr. Akira Uesugi for photographic help, and to
Dr. Toshikazu Fukui, Dainippon Pharmaceutical Co. Ltd. [k)r technical assistance. '
article_processing_charge: No
article_type: original
author:
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Kinoshita A, Ohishi H, Neki A, et al. Presynaptic localization of a metabotropic
glutamate receptor, mGluR8, in the rhinencephalic areas: A light and electron
microscope study in the rat. Neuroscience Letters. 1996;207(1):61-64. doi:10.1016/0304-3940(96)12489-7'
apa: 'Kinoshita, A., Ohishi, H., Neki, A., Nomura, S., Shigemoto, R., Takada, M.,
… Mizuno, N. (1996). Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. Elsevier. https://doi.org/10.1016/0304-3940(96)12489-7'
chicago: 'Kinoshita, Ayae, Hitoshi Ohishi, Akio Neki, Sakashi Nomura, Ryuichi Shigemoto,
Masahiko Takada, Shigetada Nakanishi, and Noboru Mizuno. “Presynaptic Localization
of a Metabotropic Glutamate Receptor, MGluR8, in the Rhinencephalic Areas: A Light
and Electron Microscope Study in the Rat.” Neuroscience Letters. Elsevier,
1996. https://doi.org/10.1016/0304-3940(96)12489-7.'
ieee: 'A. Kinoshita et al., “Presynaptic localization of a metabotropic glutamate
receptor, mGluR8, in the rhinencephalic areas: A light and electron microscope
study in the rat,” Neuroscience Letters, vol. 207, no. 1. Elsevier, pp.
61–64, 1996.'
ista: 'Kinoshita A, Ohishi H, Neki A, Nomura S, Shigemoto R, Takada M, Nakanishi
S, Mizuno N. 1996. Presynaptic localization of a metabotropic glutamate receptor,
mGluR8, in the rhinencephalic areas: A light and electron microscope study in
the rat. Neuroscience Letters. 207(1), 61–64.'
mla: 'Kinoshita, Ayae, et al. “Presynaptic Localization of a Metabotropic Glutamate
Receptor, MGluR8, in the Rhinencephalic Areas: A Light and Electron Microscope
Study in the Rat.” Neuroscience Letters, vol. 207, no. 1, Elsevier, 1996,
pp. 61–64, doi:10.1016/0304-3940(96)12489-7.'
short: A. Kinoshita, H. Ohishi, A. Neki, S. Nomura, R. Shigemoto, M. Takada, S.
Nakanishi, N. Mizuno, Neuroscience Letters 207 (1996) 61–64.
date_created: 2018-12-11T11:58:25Z
date_published: 1996-03-22T00:00:00Z
date_updated: 2022-08-12T09:24:06Z
day: '22'
doi: 10.1016/0304-3940(96)12489-7
extern: '1'
external_id:
pmid:
- '8710211 '
intvolume: ' 207'
issue: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 61 - 64
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4332'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Presynaptic localization of a metabotropic glutamate receptor, mGluR8, in
the rhinencephalic areas: A light and electron microscope study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 207
year: '1996'
...
---
_id: '2567'
abstract:
- lang: eng
text: Trigeminothalamic and spinothalamic-tact neurons provided with substance P
receptor (SPR) were examined in the rat by SPR immunofluorescence histochemistry
combined with Fluoro-Gold (FG) fluorescent retrograde labeling. After FG injection
in the thalamic regions, FG-labeled cells with SPR-like immunoreactivity were
seen mainly in laminae I and m of the medullary and spinal dorsal horns and lateral
spinal nucleus. In these regions, about one-fourth to one-third of FG-labeled
cells showed SPR-like immunoreactivity.
acknowledgement: "The authors are grateful for support of Dr. Kajitaro Morita in the
Morita Clinic of Internal Medicine and Pediatrics at Kadoma, Osaka, and for photographic
help of Mr. Akira Uesugi. This work was supported in part by Grants-in-Aid from
the Ministry of Education, Science and Culture of Japan. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Ding Y, Shigemoto R, Mizuno N. Distribution of trigeminothalamic and
spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. 1996;719(1-2):207-212. doi:10.1016/0006-8993(96)00064-9
apa: Li, J., Ding, Y., Shigemoto, R., & Mizuno, N. (1996). Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. Elsevier. https://doi.org/10.1016/0006-8993(96)00064-9
chicago: Li, Jin, Yu Ding, Ryuichi Shigemoto, and Noboru Mizuno. “Distribution of
Trigeminothalamic and Spinothalamic-Tract Neurons Showing Substance P Receptor-like
Immunoreactivity in the Rat.” Brain Research. Elsevier, 1996. https://doi.org/10.1016/0006-8993(96)00064-9.
ieee: J. Li, Y. Ding, R. Shigemoto, and N. Mizuno, “Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat,” Brain Research, vol. 719, no. 1–2. Elsevier, pp. 207–212,
1996.
ista: Li J, Ding Y, Shigemoto R, Mizuno N. 1996. Distribution of trigeminothalamic
and spinothalamic-tract neurons showing substance P receptor-like immunoreactivity
in the rat. Brain Research. 719(1–2), 207–212.
mla: Li, Jin, et al. “Distribution of Trigeminothalamic and Spinothalamic-Tract
Neurons Showing Substance P Receptor-like Immunoreactivity in the Rat.” Brain
Research, vol. 719, no. 1–2, Elsevier, 1996, pp. 207–12, doi:10.1016/0006-8993(96)00064-9.
short: J. Li, Y. Ding, R. Shigemoto, N. Mizuno, Brain Research 719 (1996) 207–212.
date_created: 2018-12-11T11:58:26Z
date_published: 1996-05-06T00:00:00Z
date_updated: 2022-08-12T08:25:35Z
day: '06'
doi: 10.1016/0006-8993(96)00064-9
extern: '1'
external_id:
pmid:
- '8782883 '
intvolume: ' 719'
issue: 1-2
language:
- iso: eng
month: '05'
oa_version: None
page: 207 - 212
pmid: 1
publication: Brain Research
publication_identifier:
issn:
- 0006-8993
publication_status: published
publisher: Elsevier
publist_id: '4330'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of trigeminothalamic and spinothalamic-tract neurons showing substance
P receptor-like immunoreactivity in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 719
year: '1996'
...