---
_id: '4277'
abstract:
- lang: eng
  text: 'Reproductive isolation between two taxa may be due to endogenous selection,
    which is generated by incompatibilities between the respective genomes, to exogenous
    selection, which is generated by differential adaptations to alternative environments,
    or to both. The continuing debate over the relative importance of either mode
    of selection has highlighted the need for unambiguous data on the fitness of hybrid
    genotypes. The hybrid zone between the fire-bellied toad (Bombina bombina) and
    the yellow-bellied toad (B. variegata) in central Europe involves adaptation to
    different environments, but evidence of hybrid dysfunction is equivocal. In this
    study, we followed the development under laboratory conditions of naturally laid
    eggs collected from a transect across the Bombina hybrid zone in Croatia. Fitness
    was significantly reduced in hybrid populations: Egg batches from the center of
    the hybrid zone showed significantly higher embryonic and larval mortality and
    higher frequencies of morphological abnormalities relative to either parental
    type. Overall mortality from day of egg collection to three weeks after hatching
    reached 20% in central hybrid populations, compared to 2% in pure populations.
    There was no significant difference in fitness between two parental types. Within
    hybrid populations, there was considerable variation in fitness, with some genotypes
    showing no evidence of reduced viability. We discuss the implications of these
    findings for our understanding of barriers to gene flow between species.'
acknowledgement: We thank the Perovic family for their generous hospitality in Croatia
  and B.Nurnberger, C.MacCallum, D.Howard, and ananonymous reviewer for comments on
  the manuscript. The work was supported by a Natural Environment Research Council
  studentship to LEBK.
article_processing_charge: No
article_type: original
author:
- first_name: Loeske
  full_name: Kruuk, Loeske
  last_name: Kruuk
- first_name: Jason
  full_name: Gilchrist, Jason
  last_name: Gilchrist
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Kruuk L, Gilchrist J, Barton NH. Hybrid dysfunction in fire-bellied toads (Bombina).
    <i>Evolution; International Journal of Organic Evolution</i>. 1999;53(5):1611-1616.
    doi:<a href="https://doi.org/10.2307/2640907">10.2307/2640907</a>
  apa: Kruuk, L., Gilchrist, J., &#38; Barton, N. H. (1999). Hybrid dysfunction in
    fire-bellied toads (Bombina). <i>Evolution; International Journal of Organic Evolution</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.2307/2640907">https://doi.org/10.2307/2640907</a>
  chicago: Kruuk, Loeske, Jason Gilchrist, and Nicholas H Barton. “Hybrid Dysfunction
    in Fire-Bellied Toads (Bombina).” <i>Evolution; International Journal of Organic
    Evolution</i>. Wiley-Blackwell, 1999. <a href="https://doi.org/10.2307/2640907">https://doi.org/10.2307/2640907</a>.
  ieee: L. Kruuk, J. Gilchrist, and N. H. Barton, “Hybrid dysfunction in fire-bellied
    toads (Bombina),” <i>Evolution; International Journal of Organic Evolution</i>,
    vol. 53, no. 5. Wiley-Blackwell, pp. 1611–1616, 1999.
  ista: Kruuk L, Gilchrist J, Barton NH. 1999. Hybrid dysfunction in fire-bellied
    toads (Bombina). Evolution; International Journal of Organic Evolution. 53(5),
    1611–1616.
  mla: Kruuk, Loeske, et al. “Hybrid Dysfunction in Fire-Bellied Toads (Bombina).”
    <i>Evolution; International Journal of Organic Evolution</i>, vol. 53, no. 5,
    Wiley-Blackwell, 1999, pp. 1611–16, doi:<a href="https://doi.org/10.2307/2640907">10.2307/2640907</a>.
  short: L. Kruuk, J. Gilchrist, N.H. Barton, Evolution; International Journal of
    Organic Evolution 53 (1999) 1611–1616.
date_created: 2018-12-11T12:08:00Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-06T08:20:03Z
day: '01'
doi: 10.2307/2640907
extern: '1'
external_id:
  pmid:
  - '28565554'
intvolume: '        53'
issue: '5'
language:
- iso: eng
month: '10'
oa_version: None
page: 1611 - 1616
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
  issn:
  - 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1811'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hybrid dysfunction in fire-bellied toads (Bombina)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 53
year: '1999'
...
---
_id: '4279'
abstract:
- lang: eng
  text: In this article we describe the structure of a hybrid zone in Argyll, Scotland,
    between native red deer (Cervus elaphus) and introduced Japanese sika deer (Cervus
    nippon), on the basis of a genetic analysis using 11 microsatellite markers and
    mitochondrial DNA. In contrast to the findings of a previous study of the same
    population, we conclude that the deer fall into two distinct genetic classes,
    corresponding to either a sika-like or red- like phenotype. Introgression is rare
    at any one locus, but where the taxa overlap up to 40% of deer carry apparently
    introgressed alleles. While most putative hybrids are heterozygous at only one
    locus, there are rare multiple heterozygotes, reflecting significant linkage disequilibrium
    within both sika- and red-like populations. The rate of backcrossing into the
    sika population is estimated as H = 0.002 per generation and into red, H = 0.001
    per generation. On the basis of historical evidence that red deer entered Kintyre
    only recently, a diffusion model evaluated by maximum likelihood shows that sika
    have increased at ~9.2% yr-1 from low frequency and disperse at a rate of ~3.7
    km yr-1. Introgression into the red-like population is greater in the south, while
    introgression into sika varies little along the transect. For both sika- and red-like
    populations, the degree of introgression is 30-40% of that predicted from the
    rates of current hybridization inferred from linkage disequilibria; however, in
    neither case is this statistically significant evidence for selection against
    introgression.
acknowledgement: We are grateful to Forest Enterprise in Argyll for providing the
  samples used in this study. We also thank Loeske Kruuk plus the communicating editor
  and two anonymous referees for their helpful comments on the manuscript. This work
  was supported by a Natural Environment Research Council grant to N.B. and J.P. and
  by a University of Edinburgh postgraduate bursary to G.S.
article_processing_charge: No
article_type: original
author:
- first_name: Simon
  full_name: Goodman, Simon
  last_name: Goodman
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Graeme
  full_name: Swanson, Graeme
  last_name: Swanson
- first_name: Kate
  full_name: Abernethy, Kate
  last_name: Abernethy
- first_name: Josephine
  full_name: Pemberton, Josephine
  last_name: Pemberton
citation:
  ama: 'Goodman S, Barton NH, Swanson G, Abernethy K, Pemberton J. Introgression through
    rare hybridisation: A genetic study of a hybrid zone between red and sika deer
    (genus Cervus), in Argyll, Scotland. <i>Genetics</i>. 1999;152(1):355-371. doi:<a
    href="https://doi.org/10.1093/genetics/152.1.355">10.1093/genetics/152.1.355</a>'
  apa: 'Goodman, S., Barton, N. H., Swanson, G., Abernethy, K., &#38; Pemberton, J.
    (1999). Introgression through rare hybridisation: A genetic study of a hybrid
    zone between red and sika deer (genus Cervus), in Argyll, Scotland. <i>Genetics</i>.
    Genetics Society of America. <a href="https://doi.org/10.1093/genetics/152.1.355">https://doi.org/10.1093/genetics/152.1.355</a>'
  chicago: 'Goodman, Simon, Nicholas H Barton, Graeme Swanson, Kate Abernethy, and
    Josephine Pemberton. “Introgression through Rare Hybridisation: A Genetic Study
    of a Hybrid Zone between Red and Sika Deer (Genus Cervus), in Argyll, Scotland.”
    <i>Genetics</i>. Genetics Society of America, 1999. <a href="https://doi.org/10.1093/genetics/152.1.355">https://doi.org/10.1093/genetics/152.1.355</a>.'
  ieee: 'S. Goodman, N. H. Barton, G. Swanson, K. Abernethy, and J. Pemberton, “Introgression
    through rare hybridisation: A genetic study of a hybrid zone between red and sika
    deer (genus Cervus), in Argyll, Scotland,” <i>Genetics</i>, vol. 152, no. 1. Genetics
    Society of America, pp. 355–371, 1999.'
  ista: 'Goodman S, Barton NH, Swanson G, Abernethy K, Pemberton J. 1999. Introgression
    through rare hybridisation: A genetic study of a hybrid zone between red and sika
    deer (genus Cervus), in Argyll, Scotland. Genetics. 152(1), 355–371.'
  mla: 'Goodman, Simon, et al. “Introgression through Rare Hybridisation: A Genetic
    Study of a Hybrid Zone between Red and Sika Deer (Genus Cervus), in Argyll, Scotland.”
    <i>Genetics</i>, vol. 152, no. 1, Genetics Society of America, 1999, pp. 355–71,
    doi:<a href="https://doi.org/10.1093/genetics/152.1.355">10.1093/genetics/152.1.355</a>.'
  short: S. Goodman, N.H. Barton, G. Swanson, K. Abernethy, J. Pemberton, Genetics
    152 (1999) 355–371.
date_created: 2018-12-11T12:08:01Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2022-09-06T08:12:14Z
day: '01'
doi: 10.1093/genetics/152.1.355
extern: '1'
external_id:
  pmid:
  - '10224266'
intvolume: '       152'
issue: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 355 - 371
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1809'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Introgression through rare hybridisation: A genetic study of a hybrid zone
  between red and sika deer (genus Cervus), in Argyll, Scotland'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 152
year: '1999'
...
---
_id: '4411'
abstract:
- lang: eng
  text: "Model checking algorithms for the verification of reactive systems proceed
    by a systematic and exhaustive exploration of the system state space. They do
    not scale to large designs because of the state explosion problem --the number
    of states grows exponentially with the number of components in the design. Consequently,
    the model checking problem is PSPACE-hard in the size of the design description.
    This dissertation proposes three novel techniques to combat the state explosion
    problem.\r\n\r\nOne of the most important advances in model checking in recent
    years has been the discovery of symbolic methods, which use a calculus of expressions,
    such as binary decision diagrams, to represent the state sets encountered during
    state space exploration. Symbolic model checking has proved to be effective for
    verifying hardware designs. Traditionally, symbolic checking of temporal logic
    specifications is performed by backward fixpoint reasoning with the operator Pre.
    Backward reasoning can be wasteful since unreachable states are explored. We suggest
    the use of forward fixpoint reasoning based on the operator Post. We show how
    all linear temporal logic specifications can be model checked symbolically by
    forward reasoning. In contrast to backward reasoning, forward reasoning performs
    computations only on the reachable states.\r\n\r\nHeuristics that improve algorithms
    for application domains, such as symbolic methods for hardware designs, are useful
    but not enough to make model checking feasible on industrial designs. Currently,
    exhaustive state exploration is possible only on designs with about 50-100 boolean
    state variables. Assume-guarantee verification attempts to combat the state explosion
    problem by using the principle of &quot;divide and conquer,&quot; where the components
    of the implementation are analyzed one at a time. Typically, an implementation
    component refines its specification only when its inputs are suitably constrained
    by other components in the implementation. The assume-guarantee principle states
    that instead of constraining the inputs by implementation components, it is sound
    to constrain them by the corresponding specification components, which can be
    significantly smaller. We extend the assume-guarantee proof rule to deal with
    the case where the specification operates at a coarser time scale than the implementation.
    Using our model checker Mocha, which implements this methodology, we verify VGI,
    a parallel DSP processor chip with 64 compute processors each containing approximately
    800 state variables and 30K gates.\r\n\r\nOur third contribution is a systematic
    model checking methodology for verifying the abstract shared-memory interface
    of sequential consistency on multiprocessor systems with three parameters --number
    of processors, number of memory locations, and number of data values. Sequential
    consistency requires that some interleaving of the local temporal orders of read/write
    events at different processors be a trace of serial memory. Therefore, it suffices
    to construct a non-interfering serializer that watches and reorders read/write
    events so that a trace of serial memory is obtained. While in general such a serializer
    must be unbounded even for fixed values of the parameters --checking sequential
    consistency is undecidable!-- we show that the paradigmatic class of snoopy cache
    coherence protocols has finite-state serializers. In order to reduce the arbitrary-parameter
    problem to the fixed-parameter problem, we develop a novel framework for induction
    over the number of processors and use the notion of a serializer to reduce the
    problem of verifying sequential consistency to that of checking language inclusion
    between finite state machines."
article_processing_charge: No
author:
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
citation:
  ama: Qadeer S. Algorithms and Methodology for Scalable Model Checking. 1999:1-150.
  apa: Qadeer, S. (1999). <i>Algorithms and Methodology for Scalable Model Checking</i>.
    University of California, Berkeley.
  chicago: Qadeer, Shaz. “Algorithms and Methodology for Scalable Model Checking.”
    University of California, Berkeley, 1999.
  ieee: S. Qadeer, “Algorithms and Methodology for Scalable Model Checking,” University
    of California, Berkeley, 1999.
  ista: Qadeer S. 1999. Algorithms and Methodology for Scalable Model Checking. University
    of California, Berkeley.
  mla: Qadeer, Shaz. <i>Algorithms and Methodology for Scalable Model Checking</i>.
    University of California, Berkeley, 1999, pp. 1–150.
  short: S. Qadeer, Algorithms and Methodology for Scalable Model Checking, University
    of California, Berkeley, 1999.
date_created: 2018-12-11T12:08:43Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-06T08:07:40Z
day: '01'
degree_awarded: PhD
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.microsoft.com/en-us/research/publication/algorithms-methodology-scalable-model-checking/
month: '10'
oa_version: None
page: 1 - 150
publication_status: published
publisher: University of California, Berkeley
publist_id: '321'
status: public
supervisor:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000-0002-2985-7724
- first_name: Robert
  full_name: Bryton, Robert
  last_name: Bryton
- first_name: John
  full_name: Steel, John
  last_name: Steel
title: Algorithms and Methodology for Scalable Model Checking
type: dissertation
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1999'
...
---
_id: '4442'
abstract:
- lang: eng
  text: Rectangular hybrid automata model digital control programs of analog plant
    environments. We study rectangular hybrid automata where the plant state evolves
    continuously in real-numbered time, and the controller samples the plant state
    and changes the control state discretely, only at the integer points in time.
    We prove that rectangular hybrid automata have finite bisimilarity quotients when
    all control transitions happen at integer times, even if the constraints on the
    derivatives of the variables vary between control states. This is in contrast
    with the conventional model where control transitions may happen at any real time,
    and already the reachability problem is undecidable. Based on the finite bisimilarity
    quotients, we give an exponential algorithm for the symbolic sampling-controller
    synthesis of rectangular automata. We show our algorithm to be optimal by proving
    the problem to be EXPTIME-hard. We also show that rectangular automata form a
    maximal class of systems for which the sampling-controller synthesis problem can
    be solved algorithmically.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Peter
  full_name: Kopke, Peter
  last_name: Kopke
citation:
  ama: Henzinger TA, Kopke P. Discrete-time control for rectangular hybrid automata.
    <i>Theoretical Computer Science</i>. 1999;221(1-2):369-392. doi:<a href="https://doi.org/10.1016/S0304-3975(99)00038-9">10.1016/S0304-3975(99)00038-9</a>
  apa: Henzinger, T. A., &#38; Kopke, P. (1999). Discrete-time control for rectangular
    hybrid automata. <i>Theoretical Computer Science</i>. Elsevier. <a href="https://doi.org/10.1016/S0304-3975(99)00038-9">https://doi.org/10.1016/S0304-3975(99)00038-9</a>
  chicago: Henzinger, Thomas A, and Peter Kopke. “Discrete-Time Control for Rectangular
    Hybrid Automata.” <i>Theoretical Computer Science</i>. Elsevier, 1999. <a href="https://doi.org/10.1016/S0304-3975(99)00038-9">https://doi.org/10.1016/S0304-3975(99)00038-9</a>.
  ieee: T. A. Henzinger and P. Kopke, “Discrete-time control for rectangular hybrid
    automata,” <i>Theoretical Computer Science</i>, vol. 221, no. 1–2. Elsevier, pp.
    369–392, 1999.
  ista: Henzinger TA, Kopke P. 1999. Discrete-time control for rectangular hybrid
    automata. Theoretical Computer Science. 221(1–2), 369–392.
  mla: Henzinger, Thomas A., and Peter Kopke. “Discrete-Time Control for Rectangular
    Hybrid Automata.” <i>Theoretical Computer Science</i>, vol. 221, no. 1–2, Elsevier,
    1999, pp. 369–92, doi:<a href="https://doi.org/10.1016/S0304-3975(99)00038-9">10.1016/S0304-3975(99)00038-9</a>.
  short: T.A. Henzinger, P. Kopke, Theoretical Computer Science 221 (1999) 369–392.
date_created: 2018-12-11T12:08:52Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-06T08:03:48Z
day: '01'
doi: 10.1016/S0304-3975(99)00038-9
extern: '1'
intvolume: '       221'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 369 - 392
publication: Theoretical Computer Science
publication_identifier:
  issn:
  - 0304-3975
publication_status: published
publisher: Elsevier
publist_id: '290'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discrete-time control for rectangular hybrid automata
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 221
year: '1999'
...
---
_id: '4480'
abstract:
- lang: eng
  text: 'We describe the formal specification and verification of the VGI parallel
    DSP chip [1], which contains 64 compute processors with ~30K gates in each processor.
    Our effort coincided in time with the “informal” verification stage of the chip.
    By interacting with the designers, we produced an abstract but executable specification
    of the design which embodies the programmer''s view of the system. Given the size
    of the design, an automatic check that even one of the 64 processors satisfies
    its specification is well beyond the scope of current verification tools. However,
    the check can be decomposed using assume-guarantee reasoning. For VGI, the implementation
    and specification operate at different time scales: several steps of the implementation
    correspond to a single step in the specification. We generalized both the assume-guarantee
    method and our model checker MOCHA to allow compositional verification for such
    applications. We used our proof rule to decompose the verification problem of
    the VGI chip into smaller proof obligations that were discharged automatically
    by MOCHA. Using our formal approach, we uncovered and fixed subtle bugs that were
    unknown to the designers.'
article_processing_charge: No
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Xiaojun
  full_name: Liu, Xiaojun
  last_name: Liu
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
- first_name: Sriram
  full_name: Rajamani, Sriram
  last_name: Rajamani
citation:
  ama: 'Henzinger TA, Liu X, Qadeer S, Rajamani S. Formal specification and verification
    of a dataflow processor array. In: IEEE; 1999:494-499. doi:<a href="https://doi.org/10.1109/ICCAD.1999.810700">10.1109/ICCAD.1999.810700</a>'
  apa: 'Henzinger, T. A., Liu, X., Qadeer, S., &#38; Rajamani, S. (1999). Formal specification
    and verification of a dataflow processor array (pp. 494–499). Presented at the
    ICCAD: Computer-Aided Design, San Jose, CA, United States of America: IEEE. <a
    href="https://doi.org/10.1109/ICCAD.1999.810700">https://doi.org/10.1109/ICCAD.1999.810700</a>'
  chicago: Henzinger, Thomas A, Xiaojun Liu, Shaz Qadeer, and Sriram Rajamani. “Formal
    Specification and Verification of a Dataflow Processor Array,” 494–99. IEEE, 1999.
    <a href="https://doi.org/10.1109/ICCAD.1999.810700">https://doi.org/10.1109/ICCAD.1999.810700</a>.
  ieee: 'T. A. Henzinger, X. Liu, S. Qadeer, and S. Rajamani, “Formal specification
    and verification of a dataflow processor array,” presented at the ICCAD: Computer-Aided
    Design, San Jose, CA, United States of America, 1999, pp. 494–499.'
  ista: 'Henzinger TA, Liu X, Qadeer S, Rajamani S. 1999. Formal specification and
    verification of a dataflow processor array. ICCAD: Computer-Aided Design, 494–499.'
  mla: Henzinger, Thomas A., et al. <i>Formal Specification and Verification of a
    Dataflow Processor Array</i>. IEEE, 1999, pp. 494–99, doi:<a href="https://doi.org/10.1109/ICCAD.1999.810700">10.1109/ICCAD.1999.810700</a>.
  short: T.A. Henzinger, X. Liu, S. Qadeer, S. Rajamani, in:, IEEE, 1999, pp. 494–499.
conference:
  end_date: 1999-11-11
  location: San Jose, CA, United States of America
  name: 'ICCAD: Computer-Aided Design'
  start_date: 1999-11-07
date_created: 2018-12-11T12:09:04Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-05T14:48:48Z
day: '01'
doi: 10.1109/ICCAD.1999.810700
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 494 - 499
publication_identifier:
  issn:
  - 1092-3152
publication_status: published
publisher: IEEE
publist_id: '246'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Formal specification and verification of a dataflow processor array
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1999'
...
---
_id: '4484'
abstract:
- lang: eng
  text: "In shared-memory multiprocessors sequential consistency offers a natural
    tradeoff between the flexibility afforded to the implementor and the complexity
    of the programmer’s view of the memory. Sequential consistency requires that some
    interleaving of the local temporal orders of read/write events at different processors
    be a trace of serial memory. We develop a systematic methodology for proving sequential
    consistency for memory systems with three parameters —number of processors, number
    of memory locations, and number of data values. From the definition of sequential
    consistency it suffices to construct a non-interfering observer that watches and
    reorders read/write events so that a trace of serial memory is obtained. While
    in general such an observer must be unbounded even for fixed values of the parameters
    —checking sequential consistency is undecidable!— we show that for two paradigmatic
    protocol classes—lazy caching and snoopy cache coherence—there exist finite-state
    observers. In these cases, sequential consistency for fixed parameter values can
    thus be checked by language inclusion between finite automata.\r\nIn order to
    reduce the arbitrary-parameter problem to the fixed-parameter problem, we develop
    a novel framework for induction over the number of processors. Classical induction
    schemas, which are based on process invariants that are inductive with respect
    to an implementation preorder that preserves the temporal sequence of events,
    are inadequate for our purposes, because proving sequential consistency requires
    the reordering of events. Hence we introduce merge invariants, which permit certain
    reorderings of read/write events. We show that under certain reasonable assumptions
    about the memory system, it is possible to conclude sequential consistency for
    any number of processors, memory locations, and data values by model checking
    two finite-state lemmas about process and merge invariants: they involve two processors
    each accessing a maximum of three locations, where each location stores at most
    two data values. For both lazy caching and snoopy cache coherence we are able
    to discharge the two lemmas using the model checker MOCHA."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
- first_name: Sriram
  full_name: Rajamani, Sriram
  last_name: Rajamani
citation:
  ama: 'Henzinger TA, Qadeer S, Rajamani S. Verifying sequential consistency on shared-memory
    multiprocessor systems. In: <i>Proceedings of the 11th International Conference
    on Computer Aided Verification</i>. Vol 1633. Springer; 1999:301-315. doi:<a href="https://doi.org/10.1007/3-540-48683-6_27">10.1007/3-540-48683-6_27</a>'
  apa: 'Henzinger, T. A., Qadeer, S., &#38; Rajamani, S. (1999). Verifying sequential
    consistency on shared-memory multiprocessor systems. In <i>Proceedings of the
    11th International Conference on Computer Aided Verification</i> (Vol. 1633, pp.
    301–315). Trento, Italy: Springer. <a href="https://doi.org/10.1007/3-540-48683-6_27">https://doi.org/10.1007/3-540-48683-6_27</a>'
  chicago: Henzinger, Thomas A, Shaz Qadeer, and Sriram Rajamani. “Verifying Sequential
    Consistency on Shared-Memory Multiprocessor Systems.” In <i>Proceedings of the
    11th International Conference on Computer Aided Verification</i>, 1633:301–15.
    Springer, 1999. <a href="https://doi.org/10.1007/3-540-48683-6_27">https://doi.org/10.1007/3-540-48683-6_27</a>.
  ieee: T. A. Henzinger, S. Qadeer, and S. Rajamani, “Verifying sequential consistency
    on shared-memory multiprocessor systems,” in <i>Proceedings of the 11th International
    Conference on Computer Aided Verification</i>, Trento, Italy, 1999, vol. 1633,
    pp. 301–315.
  ista: 'Henzinger TA, Qadeer S, Rajamani S. 1999. Verifying sequential consistency
    on shared-memory multiprocessor systems. Proceedings of the 11th International
    Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS,
    vol. 1633, 301–315.'
  mla: Henzinger, Thomas A., et al. “Verifying Sequential Consistency on Shared-Memory
    Multiprocessor Systems.” <i>Proceedings of the 11th International Conference on
    Computer Aided Verification</i>, vol. 1633, Springer, 1999, pp. 301–15, doi:<a
    href="https://doi.org/10.1007/3-540-48683-6_27">10.1007/3-540-48683-6_27</a>.
  short: T.A. Henzinger, S. Qadeer, S. Rajamani, in:, Proceedings of the 11th International
    Conference on Computer Aided Verification, Springer, 1999, pp. 301–315.
conference:
  end_date: 1999-07-10
  location: Trento, Italy
  name: 'CAV: Computer Aided Verification'
  start_date: 1999-07-06
date_created: 2018-12-11T12:09:05Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-02T09:21:11Z
day: '01'
doi: 10.1007/3-540-48683-6_27
extern: '1'
intvolume: '      1633'
language:
- iso: eng
month: '01'
oa_version: None
page: 301 - 315
publication: Proceedings of the 11th International Conference on Computer Aided Verification
publication_identifier:
  isbn:
  - '9783540662020'
publication_status: published
publisher: Springer
publist_id: '244'
quality_controlled: '1'
status: public
title: Verifying sequential consistency on shared-memory multiprocessor systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1633
year: '1999'
...
---
_id: '4485'
abstract:
- lang: eng
  text: 'In order to study control problems for hybrid systems, we generalize hybrid
    automata to hybrid games —say, controller vs. plant. If we specify the continuous
    dynamics by constant lower and upper bounds, we obtain rectangular games. We show
    that for rectangular games with objectives expressed in Ltl (linear temporal logic),
    the winning states for each player can be computed, and winning strategies can
    be synthesized. Our result is sharp, as already reachability is undecidable for
    generalizations of rectangular systems, and optimal —singly exponential in the
    size of the game structure and doubly exponential in the size of the Ltl objective.
    Our proof systematically generalizes the theory of hybrid systems from automata
    (single-player structures) [9] to games (multi-player structures): we show that
    the successively more general infinite-state classes of timed, 2D rectangular,
    and rectangular games induce successively weaker, but still finite, quotient structures
    called game bisimilarity, game similarity, and game trace equivalence. These quotients
    can be used, in particular, to solve the Ltl control problem.'
acknowledgement: This research was supported in part by the NSF CAREER award CCR-9501708,
  by the NSF grant CCR-9504469, by the DARPA (NASA Ames) grant NAG2-1214, by the DARPA
  (Wright-Patterson AFB) grant F33615-98-C-3614, and by the ARO MURI grant DAAH-04-96-1-0341.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Benjamin
  full_name: Horowitz, Benjamin
  last_name: Horowitz
- first_name: Ritankar
  full_name: Majumdar, Ritankar
  last_name: Majumdar
citation:
  ama: 'Henzinger TA, Horowitz B, Majumdar R. Rectangular hybrid games. In: <i>Proceedings
    of the 10th International Conference on Concurrency Theory</i>. Vol 1664. Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik; 1999:320-335. doi:<a href="https://doi.org/10.1007/3-540-48320-9_23">10.1007/3-540-48320-9_23</a>'
  apa: 'Henzinger, T. A., Horowitz, B., &#38; Majumdar, R. (1999). Rectangular hybrid
    games. In <i>Proceedings of the 10th International Conference on Concurrency Theory</i>
    (Vol. 1664, pp. 320–335). Eindhoven, The Netherlands: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.1007/3-540-48320-9_23">https://doi.org/10.1007/3-540-48320-9_23</a>'
  chicago: Henzinger, Thomas A, Benjamin Horowitz, and Ritankar Majumdar. “Rectangular
    Hybrid Games.” In <i>Proceedings of the 10th International Conference on Concurrency
    Theory</i>, 1664:320–35. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1999.
    <a href="https://doi.org/10.1007/3-540-48320-9_23">https://doi.org/10.1007/3-540-48320-9_23</a>.
  ieee: T. A. Henzinger, B. Horowitz, and R. Majumdar, “Rectangular hybrid games,”
    in <i>Proceedings of the 10th International Conference on Concurrency Theory</i>,
    Eindhoven, The Netherlands, 1999, vol. 1664, pp. 320–335.
  ista: 'Henzinger TA, Horowitz B, Majumdar R. 1999. Rectangular hybrid games. Proceedings
    of the 10th International Conference on Concurrency Theory. CONCUR: Concurrency
    Theory, LNCS, vol. 1664, 320–335.'
  mla: Henzinger, Thomas A., et al. “Rectangular Hybrid Games.” <i>Proceedings of
    the 10th International Conference on Concurrency Theory</i>, vol. 1664, Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 1999, pp. 320–35, doi:<a href="https://doi.org/10.1007/3-540-48320-9_23">10.1007/3-540-48320-9_23</a>.
  short: T.A. Henzinger, B. Horowitz, R. Majumdar, in:, Proceedings of the 10th International
    Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    1999, pp. 320–335.
conference:
  location: Eindhoven, The Netherlands
  name: 'CONCUR: Concurrency Theory'
date_created: 2018-12-11T12:09:05Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-02T10:54:12Z
day: '01'
doi: 10.1007/3-540-48320-9_23
extern: '1'
intvolume: '      1664'
language:
- iso: eng
month: '01'
oa_version: None
page: 320 - 335
publication: Proceedings of the 10th International Conference on Concurrency Theory
publication_identifier:
  isbn:
  - '9783540664253'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '245'
quality_controlled: '1'
status: public
title: Rectangular hybrid games
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1664
year: '1999'
...
---
_id: '4487'
abstract:
- lang: eng
  text: Refinement checking is used to verify implementations against more abstract
    specifications. Assume-guarantee reasoning is used to decompose refinement proofs
    in order to avoid state-space explosion. In previous approaches, specifications
    are forced to operate on the same time scale as the implementation. This may lead
    to unnatural specifications and inefficiencies in verification. We introduce a
    novel methodology for decomposing refinement proofs of temporally abstract specifications,
    which specify implementation requirements only at certain sampling instances in
    time. Our new assume-guarantee rule allows separate refinement maps for specifying
    functionality and timing.We present the theory for the correctness of our methodology,
    and illustrate it using a simple example. Support for sampling and the generalized
    assume-guarantee rule have been implemented in the model checker Mocha and successfully
    applied to verify the VGI multiprocessor dataflow chip with 6 million transistors.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Shaz
  full_name: Qadeer, Shaz
  last_name: Qadeer
- first_name: Sriram
  full_name: Rajamani, Sriram
  last_name: Rajamani
citation:
  ama: 'Henzinger TA, Qadeer S, Rajamani S. Assume-guarantee refinement between different
    time scales. In: <i>Proceedings of the 11th International Conference on Computer
    Aided Verification</i>. Vol 1633. Springer; 1999:208-221. doi:<a href="https://doi.org/10.1007/3-540-48683-6_20">10.1007/3-540-48683-6_20</a>'
  apa: 'Henzinger, T. A., Qadeer, S., &#38; Rajamani, S. (1999). Assume-guarantee
    refinement between different time scales. In <i>Proceedings of the 11th International
    Conference on Computer Aided Verification</i> (Vol. 1633, pp. 208–221). Trento,
    Italy: Springer. <a href="https://doi.org/10.1007/3-540-48683-6_20">https://doi.org/10.1007/3-540-48683-6_20</a>'
  chicago: Henzinger, Thomas A, Shaz Qadeer, and Sriram Rajamani. “Assume-Guarantee
    Refinement between Different Time Scales.” In <i>Proceedings of the 11th International
    Conference on Computer Aided Verification</i>, 1633:208–21. Springer, 1999. <a
    href="https://doi.org/10.1007/3-540-48683-6_20">https://doi.org/10.1007/3-540-48683-6_20</a>.
  ieee: T. A. Henzinger, S. Qadeer, and S. Rajamani, “Assume-guarantee refinement
    between different time scales,” in <i>Proceedings of the 11th International Conference
    on Computer Aided Verification</i>, Trento, Italy, 1999, vol. 1633, pp. 208–221.
  ista: 'Henzinger TA, Qadeer S, Rajamani S. 1999. Assume-guarantee refinement between
    different time scales. Proceedings of the 11th International Conference on Computer
    Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 1633, 208–221.'
  mla: Henzinger, Thomas A., et al. “Assume-Guarantee Refinement between Different
    Time Scales.” <i>Proceedings of the 11th International Conference on Computer
    Aided Verification</i>, vol. 1633, Springer, 1999, pp. 208–21, doi:<a href="https://doi.org/10.1007/3-540-48683-6_20">10.1007/3-540-48683-6_20</a>.
  short: T.A. Henzinger, S. Qadeer, S. Rajamani, in:, Proceedings of the 11th International
    Conference on Computer Aided Verification, Springer, 1999, pp. 208–221.
conference:
  end_date: 1999-07-10
  location: Trento, Italy
  name: 'CAV: Computer Aided Verification'
  start_date: 1999-07-06
date_created: 2018-12-11T12:09:06Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-02T09:04:26Z
day: '01'
doi: 10.1007/3-540-48683-6_20
extern: '1'
intvolume: '      1633'
language:
- iso: eng
month: '01'
oa_version: None
page: 208 - 221
publication: Proceedings of the 11th International Conference on Computer Aided Verification
publication_identifier:
  isbn:
  - '9783540662020'
publication_status: published
publisher: Springer
publist_id: '243'
quality_controlled: '1'
status: public
title: Assume-guarantee refinement between different time scales
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1633
year: '1999'
...
---
_id: '4582'
abstract:
- lang: eng
  text: "We present a formal model for concurrent systems. The model represents synchronous
    and asynchronous components in a uniform framework that supports compositional
    (assume-guarantee) and hierarchical (stepwise-refinement) design and verification.
    While synchronous models are based on a notion of atomic computation step, and
    asynchronous models remove that notion by introducing stuttering, our model is
    based on a flexible notion of what constitutes a computation step: by applying
    an abstraction operator to a system, arbitrarily many consecutive steps can be
    collapsed into a single step. The abstraction operator, which may turn an asynchronous
    system into a synchronous one, allows us to describe systems at various levels
    of temporal detail. For describing systems at various levels of spatial detail,
    we use a hiding operator that may turn a synchronous system into an asynchronous
    one. We illustrate the model with diverse examples from synchronous circuits,
    asynchronous shared-memory programs, and synchronous message-passing protocols.\r\n"
acknowledgement: "We thank Albert Benveniste, Bob Kurshan, Ken McMillan, Amir Pnueli,
  and the VIS group at UC Berkeley for fruitful discussions. We also thank the anonymous
  referees for suggesting improvements. Alur was supported in part by the DARPA/NASA
  grant NAG2-1214 and Henzinger was supported in part by the ONR YIP award N00014-95-1-0520,
  the\r\nNSF CAREER award CCR-9501708, the NSF grant CCR-9504469, the DARPA/NASA grant
  NAG2-1214, and by the SRC contract 97-DC-324.041."
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: Alur R, Henzinger TA. Reactive modules. <i>Formal Methods in System Design</i>.
    1999;15(1):7-48. doi:<a href="https://doi.org/10.1023/A:1008739929481">10.1023/A:1008739929481</a>
  apa: Alur, R., &#38; Henzinger, T. A. (1999). Reactive modules. <i>Formal Methods
    in System Design</i>. Springer. <a href="https://doi.org/10.1023/A:1008739929481">https://doi.org/10.1023/A:1008739929481</a>
  chicago: Alur, Rajeev, and Thomas A Henzinger. “Reactive Modules.” <i>Formal Methods
    in System Design</i>. Springer, 1999. <a href="https://doi.org/10.1023/A:1008739929481">https://doi.org/10.1023/A:1008739929481</a>.
  ieee: R. Alur and T. A. Henzinger, “Reactive modules,” <i>Formal Methods in System
    Design</i>, vol. 15, no. 1. Springer, pp. 7–48, 1999.
  ista: Alur R, Henzinger TA. 1999. Reactive modules. Formal Methods in System Design.
    15(1), 7–48.
  mla: Alur, Rajeev, and Thomas A. Henzinger. “Reactive Modules.” <i>Formal Methods
    in System Design</i>, vol. 15, no. 1, Springer, 1999, pp. 7–48, doi:<a href="https://doi.org/10.1023/A:1008739929481">10.1023/A:1008739929481</a>.
  short: R. Alur, T.A. Henzinger, Formal Methods in System Design 15 (1999) 7–48.
date_created: 2018-12-11T12:09:35Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-02T08:45:58Z
day: '01'
doi: 10.1023/A:1008739929481
extern: '1'
intvolume: '        15'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 7 - 48
publication: Formal Methods in System Design
publication_identifier:
  issn:
  - 0925-9856
publication_status: published
publisher: Springer
publist_id: '125'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reactive modules
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1999'
...
---
_id: '4601'
abstract:
- lang: eng
  text: "Temporal logic comes in two varieties: linear-time temporal logic assumes
    implicit universal quantification over all paths that are generated by system
    moves; branching-time temporal logic allows explicit existential and universal
    quantification over all paths. We introduce a third, more general variety of temporal
    logic: alternating-time temporal logic offers selective quantification over those
    paths that are possible outcomes of games, such as the game in which the system
    and the environment alternate moves. While linear-time and branching-time logics
    are natural specification languages for closed systems, alternating-time logics
    are natural specification languages for open systems. For example, by preceding
    the temporal operator “eventually” with a selective path quantifier, we can specify
    that in the game between the system and the environment, the system has a strategy
    to reach a certain state. Also the problems of receptiveness, realizability, and
    controllability can be formulated as model-checking problems for alternating-time
    formulas.\r\nDepending on whether we admit arbitrary nesting of selective path
    quantifiers and temporal operators, we obtain the two alternating-time temporal
    logics ATL and ATL. We interpret the formulas of ATL and ATL over alternating
    transition systems. While in ordinary transition systems, each transition corresponds
    to a possible step of the system, in alternating transition systems, each transition
    corresponds to a possible move in the game between the system and the environment.
    Fair alternating transition systems can capture both synchronous and asynchronous
    compositions of open systems. For synchronous systems, the expressive power of
    ATL beyond CTL comes at no cost: the model-checking complexity of synchronous
    ATL is linear in the size of the system and the length of the formula. The symbolic
    model-checking algorithm for CTL extends with few modifications to synchronous
    ATL, and with some work, also to asynchronous ATL, whose model-checking complexity
    is quadratic. This makes ATL an obvious candidate for the automatic verification
    of open systems. In the case of ATL, the model-checking problem is closely related
    to the synthesis problem for linear-time formulas, and requires doubly exponential
    time for both synchronous and asynchronous systems.\r\nA preliminary version of
    this paper appeared in the Proceedings of the 38th IEEE Symposium on Foundations
    of Computer Science (FOCS 1997), pp. 100–109."
acknowledgement: This work was supported in part by the ONR YIP award N00014-95-1-0520,
  by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
  contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
  grant NAG2-892, and by the SRC contract 97-DC-324.041.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Orna
  full_name: Kupferman, Orna
  last_name: Kupferman
citation:
  ama: 'Alur R, Henzinger TA, Kupferman O. Alternating-time temporal logic. In: <i>Proceedings
    of the International Symposium on Compositionality</i>. Vol 1536. Springer; 1999:23-60.
    doi:<a href="https://doi.org/10.1007/3-540-49213-5_2">10.1007/3-540-49213-5_2</a>'
  apa: 'Alur, R., Henzinger, T. A., &#38; Kupferman, O. (1999). Alternating-time temporal
    logic. In <i>Proceedings of the International Symposium on Compositionality</i>
    (Vol. 1536, pp. 23–60). Bad Malente, Germany: Springer. <a href="https://doi.org/10.1007/3-540-49213-5_2">https://doi.org/10.1007/3-540-49213-5_2</a>'
  chicago: Alur, Rajeev, Thomas A Henzinger, and Orna Kupferman. “Alternating-Time
    Temporal Logic.” In <i>Proceedings of the International Symposium on Compositionality</i>,
    1536:23–60. Springer, 1999. <a href="https://doi.org/10.1007/3-540-49213-5_2">https://doi.org/10.1007/3-540-49213-5_2</a>.
  ieee: R. Alur, T. A. Henzinger, and O. Kupferman, “Alternating-time temporal logic,”
    in <i>Proceedings of the International Symposium on Compositionality</i>, Bad
    Malente, Germany, 1999, vol. 1536, pp. 23–60.
  ista: 'Alur R, Henzinger TA, Kupferman O. 1999. Alternating-time temporal logic.
    Proceedings of the International Symposium on Compositionality. COMPOS: Compositionality,
    LNCS, vol. 1536, 23–60.'
  mla: Alur, Rajeev, et al. “Alternating-Time Temporal Logic.” <i>Proceedings of the
    International Symposium on Compositionality</i>, vol. 1536, Springer, 1999, pp.
    23–60, doi:<a href="https://doi.org/10.1007/3-540-49213-5_2">10.1007/3-540-49213-5_2</a>.
  short: R. Alur, T.A. Henzinger, O. Kupferman, in:, Proceedings of the International
    Symposium on Compositionality, Springer, 1999, pp. 23–60.
conference:
  end_date: 1997-09-12
  location: Bad Malente, Germany
  name: 'COMPOS: Compositionality'
  start_date: 1997-09-08
date_created: 2018-12-11T12:09:41Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-01T14:23:41Z
day: '01'
doi: 10.1007/3-540-49213-5_2
extern: '1'
intvolume: '      1536'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 60
publication: Proceedings of the International Symposium on Compositionality
publication_identifier:
  isbn:
  - '9783540654933'
publication_status: published
publisher: Springer
publist_id: '106'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Alternating-time temporal logic
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1536
year: '1999'
...
---
_id: '4602'
abstract:
- lang: eng
  text: 'Modular techniques for automatic verification attempt to overcome the state-explosion
    problem by exploiting the modular structure naturally present in many system designs.
    Unlike other tasks in the verification of finite-state systems, current modular
    techniques rely heavily on user guidance. In particular, the user is typically
    required to construct module abstractions that are neither too detailed as to
    render insufficient benefits in state exploration, nor too coarse as to invalidate
    the desired systemproperties. In this paper, we construct abstractmodules automatically,
    using reachability and controllability information about the concrete modules.
    This allows us to leverage automatic verification techniques by applying them
    in layers: first we compute on the state spaces of system components, then we
    use the results for constructing abstractions, and finally we compute on the abstract
    state space of the system. Our experimental results indicate that if reachability
    and controllability information is used in the construction of abstractions, the
    resulting abstract modules are often significantly smaller than the concrete modules
    and can drastically reduce the space and time requirements for verification.'
acknowledgement: This research was supported in part by the NSF CAREER award CCR-9734115,
  by the NSF CAREER award CCR-9501708, by the DARPA (NASA Ames) grant NAG2-1214, by
  the DARPA (Wright-Patterson AFB) grant F33615-98-C-3614, by the ARO MURI grant DAAH-
  04-96-1-0341, and by the Gigascale Silicon Research Center.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Luca
  full_name: De Alfaro, Luca
  last_name: De Alfaro
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Freddy
  full_name: Mang, Freddy
  last_name: Mang
citation:
  ama: 'Alur R, De Alfaro L, Henzinger TA, Mang F. Automating modular verification.
    In: <i>Proceedings of the 10th International Conference on Concurrency Theory</i>.
    Vol 1664. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1999:82-97. doi:<a
    href="https://doi.org/10.1007/3-540-48320-9_8">10.1007/3-540-48320-9_8</a>'
  apa: 'Alur, R., De Alfaro, L., Henzinger, T. A., &#38; Mang, F. (1999). Automating
    modular verification. In <i>Proceedings of the 10th International Conference on
    Concurrency Theory</i> (Vol. 1664, pp. 82–97). Eindhoven, The Netherlands: Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.1007/3-540-48320-9_8">https://doi.org/10.1007/3-540-48320-9_8</a>'
  chicago: Alur, Rajeev, Luca De Alfaro, Thomas A Henzinger, and Freddy Mang. “Automating
    Modular Verification.” In <i>Proceedings of the 10th International Conference
    on Concurrency Theory</i>, 1664:82–97. Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 1999. <a href="https://doi.org/10.1007/3-540-48320-9_8">https://doi.org/10.1007/3-540-48320-9_8</a>.
  ieee: R. Alur, L. De Alfaro, T. A. Henzinger, and F. Mang, “Automating modular verification,”
    in <i>Proceedings of the 10th International Conference on Concurrency Theory</i>,
    Eindhoven, The Netherlands, 1999, vol. 1664, pp. 82–97.
  ista: 'Alur R, De Alfaro L, Henzinger TA, Mang F. 1999. Automating modular verification.
    Proceedings of the 10th International Conference on Concurrency Theory. CONCUR:
    Concurrency Theory, LNCS, vol. 1664, 82–97.'
  mla: Alur, Rajeev, et al. “Automating Modular Verification.” <i>Proceedings of the
    10th International Conference on Concurrency Theory</i>, vol. 1664, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 1999, pp. 82–97, doi:<a href="https://doi.org/10.1007/3-540-48320-9_8">10.1007/3-540-48320-9_8</a>.
  short: R. Alur, L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 10th
    International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 1999, pp. 82–97.
conference:
  end_date: 1999-08-27
  location: Eindhoven, The Netherlands
  name: 'CONCUR: Concurrency Theory'
  start_date: 1999-08-24
date_created: 2018-12-11T12:09:42Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-01T14:15:35Z
day: '01'
doi: 10.1007/3-540-48320-9_8
extern: '1'
intvolume: '      1664'
language:
- iso: eng
month: '01'
oa_version: None
page: 82 - 97
publication: Proceedings of the 10th International Conference on Concurrency Theory
publication_identifier:
  isbn:
  - '9783540664253'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '105'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automating modular verification
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1664
year: '1999'
...
---
_id: '1954'
abstract:
- lang: eng
  text: "\r\nWe have examined the effects of heat stress on electron transfer in the
    thylakoid membrane of an engineered plastid ndh deletion mutant, Δ1, incapable
    of performing the Ndh-mediated reduction of the plastoquinone pool in the chloroplast.
    Upon heat stress in the dark, the rate of PSII- independent reduction of PSI after
    subsequent illumination by far-red light is dramatically enhanced in both Δ1 and
    a wild-type control plant (WT). In contrast, in the dark, only the WT shows an
    increase in the reduction state of the plastoquinone pool. We conclude that the
    heat stress-induced reduction of the intersystem electron transport chain can
    be mediated by Ndh- independent pathways in the light but that in the dark the
    dominant pathway for reduction of the plastoquinone pool is catalysed by the Ndh
    complex. Our results therefore demonstrate a functional role for the Ndh complex
    in the dark.\r\n"
acknowledgement: This work was funded by the BBSRC. We would like to thank Professor
  Peter Horton (University of Sheffield) for the loan of the ED 800 T unit.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Paul
  full_name: Burrows, Paul
  last_name: Burrows
- first_name: Peter
  full_name: Nixon, Peter
  last_name: Nixon
citation:
  ama: Sazanov LA, Burrows P, Nixon P. The chloroplast Ndh complex mediates the dark
    reduction of the plastoquinone pool in response to heat stress in tobacco leaves.
    <i>FEBS Letters</i>. 1998;429(1):115-118. doi:<a href="https://doi.org/10.1016/S0014-5793(98)00573-0">10.1016/S0014-5793(98)00573-0</a>
  apa: Sazanov, L. A., Burrows, P., &#38; Nixon, P. (1998). The chloroplast Ndh complex
    mediates the dark reduction of the plastoquinone pool in response to heat stress
    in tobacco leaves. <i>FEBS Letters</i>. Elsevier. <a href="https://doi.org/10.1016/S0014-5793(98)00573-0">https://doi.org/10.1016/S0014-5793(98)00573-0</a>
  chicago: Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “The Chloroplast Ndh
    Complex Mediates the Dark Reduction of the Plastoquinone Pool in Response to Heat
    Stress in Tobacco Leaves.” <i>FEBS Letters</i>. Elsevier, 1998. <a href="https://doi.org/10.1016/S0014-5793(98)00573-0">https://doi.org/10.1016/S0014-5793(98)00573-0</a>.
  ieee: L. A. Sazanov, P. Burrows, and P. Nixon, “The chloroplast Ndh complex mediates
    the dark reduction of the plastoquinone pool in response to heat stress in tobacco
    leaves,” <i>FEBS Letters</i>, vol. 429, no. 1. Elsevier, pp. 115–118, 1998.
  ista: Sazanov LA, Burrows P, Nixon P. 1998. The chloroplast Ndh complex mediates
    the dark reduction of the plastoquinone pool in response to heat stress in tobacco
    leaves. FEBS Letters. 429(1), 115–118.
  mla: Sazanov, Leonid A., et al. “The Chloroplast Ndh Complex Mediates the Dark Reduction
    of the Plastoquinone Pool in Response to Heat Stress in Tobacco Leaves.” <i>FEBS
    Letters</i>, vol. 429, no. 1, Elsevier, 1998, pp. 115–18, doi:<a href="https://doi.org/10.1016/S0014-5793(98)00573-0">10.1016/S0014-5793(98)00573-0</a>.
  short: L.A. Sazanov, P. Burrows, P. Nixon, FEBS Letters 429 (1998) 115–118.
date_created: 2018-12-11T11:54:54Z
date_published: 1998-06-05T00:00:00Z
date_updated: 2022-09-01T13:12:15Z
day: '05'
doi: 10.1016/S0014-5793(98)00573-0
extern: '1'
external_id:
  pmid:
  - '9657394 '
intvolume: '       429'
issue: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 115 - 118
pmid: 1
publication: FEBS Letters
publication_identifier:
  issn:
  - 0014-5793
publication_status: published
publisher: Elsevier
publist_id: '5128'
quality_controlled: '1'
status: public
title: The chloroplast Ndh complex mediates the dark reduction of the plastoquinone
  pool in response to heat stress in tobacco leaves
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 429
year: '1998'
...
---
_id: '1955'
abstract:
- lang: eng
  text: 'The plastid genomes of several plants contain homologues, termed ndh genes,
    of genes encoding subunits of the NADH:ubiquinone oxidoreductase or complex I
    of mitochondria and eubacteria. The functional significance of the Ndh proteins
    in higher plants is uncertain. We show here that tobacco chloroplasts contain
    a protein complex of 550 kDa consisting of at least three of the ndh gene products:
    NdhI, NdhJ and NdhK. We have constructed mutant tobacco plants with disrupted
    ndhC, ndhK and ndhJ plastid genes, indicating that the Ndh complex is dispensible
    for plant growth under optimal growth conditions. Chlorophyll fluorescence analysis
    shows that in vivo the Ndh complex catalyses the post-illumination reduction of
    the plastoquinone pool and in the light optimizes the induction of photosynthesis
    under conditions of water stress. We conclude that the Ndh complex catalyses the
    reduction of the plastoquinone pool using stromal reductant and so acts as a respiratory
    complex. Overall, our data are compatible with the participation of the Ndh complex
    in cyclic electron flow around the photosystem I complex in the light and possibly
    in a chloroplast respiratory chain in the dark.'
acknowledgement: We thank Professor Süss (Institute of Plant Genetics and Crop Plant
  Research, Gatersleben, Germany) for the gift of the anti-FNR antiserum, Professor
  Masahiro Sugiura (Nagoya University, Japan) for the gift of plasmid pTB19 and Professor
  Peter Horton (University of Sheffield) for the loan of his ED-800T unit. P.B. is
  a recipient of a BBSRC studentship and the work was supported by grants from the
  BBSRC, The Royal Society (to P.J.N.) and The National Science Foundation (to P.M.).
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Burrows, Paul
  last_name: Burrows
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Zóra
  full_name: Sváb, Zóra
  last_name: Sváb
- first_name: Pàl
  full_name: Maliga, Pàl
  last_name: Maliga
- first_name: Peter
  full_name: Nixon, Peter
  last_name: Nixon
citation:
  ama: Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. Identification of a functional
    respiratory complex in chloroplasts through analysis of tobacco mutants containing
    disrupted plastid ndh genes. <i>EMBO Journal</i>. 1998;17(4):868-876. doi:<a href="https://doi.org/10.1093/emboj/17.4.868">10.1093/emboj/17.4.868</a>
  apa: Burrows, P., Sazanov, L. A., Sváb, Z., Maliga, P., &#38; Nixon, P. (1998).
    Identification of a functional respiratory complex in chloroplasts through analysis
    of tobacco mutants containing disrupted plastid ndh genes. <i>EMBO Journal</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1093/emboj/17.4.868">https://doi.org/10.1093/emboj/17.4.868</a>
  chicago: Burrows, Paul, Leonid A Sazanov, Zóra Sváb, Pàl Maliga, and Peter Nixon.
    “Identification of a Functional Respiratory Complex in Chloroplasts through Analysis
    of Tobacco Mutants Containing Disrupted Plastid Ndh Genes.” <i>EMBO Journal</i>.
    Wiley-Blackwell, 1998. <a href="https://doi.org/10.1093/emboj/17.4.868">https://doi.org/10.1093/emboj/17.4.868</a>.
  ieee: P. Burrows, L. A. Sazanov, Z. Sváb, P. Maliga, and P. Nixon, “Identification
    of a functional respiratory complex in chloroplasts through analysis of tobacco
    mutants containing disrupted plastid ndh genes,” <i>EMBO Journal</i>, vol. 17,
    no. 4. Wiley-Blackwell, pp. 868–876, 1998.
  ista: Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. 1998. Identification of
    a functional respiratory complex in chloroplasts through analysis of tobacco mutants
    containing disrupted plastid ndh genes. EMBO Journal. 17(4), 868–876.
  mla: Burrows, Paul, et al. “Identification of a Functional Respiratory Complex in
    Chloroplasts through Analysis of Tobacco Mutants Containing Disrupted Plastid
    Ndh Genes.” <i>EMBO Journal</i>, vol. 17, no. 4, Wiley-Blackwell, 1998, pp. 868–76,
    doi:<a href="https://doi.org/10.1093/emboj/17.4.868">10.1093/emboj/17.4.868</a>.
  short: P. Burrows, L.A. Sazanov, Z. Sváb, P. Maliga, P. Nixon, EMBO Journal 17 (1998)
    868–876.
date_created: 2018-12-11T11:54:54Z
date_published: 1998-02-04T00:00:00Z
date_updated: 2022-09-01T13:17:49Z
day: '04'
doi: 10.1093/emboj/17.4.868
extern: '1'
external_id:
  pmid:
  - '9463365'
intvolume: '        17'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170436/
month: '02'
oa: 1
oa_version: None
page: 868 - 876
pmid: 1
publication: EMBO Journal
publication_identifier:
  issn:
  - 0261-4189
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5129'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification of a functional respiratory complex in chloroplasts through
  analysis of tobacco mutants containing disrupted plastid ndh genes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1998'
...
---
_id: '1956'
abstract:
- lang: eng
  text: "\r\nThe plastid genomes of several plants contain ndh genes-homologues of
    genes encoding subunits of the proton-pumping NADH:ubiquinone oxidoreductase,
    or complex I, involved in respiration in mitochondria and eubacteria. From sequence
    similarities with these genes, the ndh gene products have been suggested to form
    a large protein complex (Ndh complex); however, the structure and function of
    this complex remains to be established. Herein we report the isolation of the
    Ndh complex from the chloroplasts of the higher plant Pisum sativum. The purification
    procedure involved selective solubilization of the thylakoid membrane with dodecyl
    maltoside, followed by two anion-exchange chromatography steps and one size-exclusion
    chromatography step. The isolated Ndh complex has an apparent total molecular
    mass of approximately 550 kDa and according to SDS/PAGE consists of at least 16
    subunits including NdhA, NdhI, NdhJ, NdhK, and NdhH, which were identified by
    N-terminal sequencing and immunoblotting. The Ndh complex showed an NADH- and
    deamino-NADH-specific dehydrogenase activity, characteristic of complex I, when
    either ferricyanide or the quinones menadione and duroquinone were used as electron
    acceptors. This study describes the isolation of the chloroplast analogue of the
    respiratory complex I and provides direct evidence for the function of the plastid
    Ndh complex as an NADH:plastoquinone oxidoreductase. Our results are compatible
    with a dual role for the Ndh complex in the chloro-respiratory and cyclic photophosphorylation
    pathways."
acknowledgement: We gratefully acknowledge Dr. A.Carne (Institute of Cancer Research,
  London, U.K.) for help with N-terminal sequencing. We thank Prof. C. J. Leaver (University
  of Oxford, U.K.), Prof. K.-H. Süss (Institute of Plant Genetics and Crop Plant Research,
  Gatersleben, Germany), and Prof. L. J. Rogers (University of Aberystwyth, U.K.)
  for gifts of antiserum against maize mitochondrial cytochrome oxidase subunit 1
  and cytochrome bc1 complex, spinach FNR, and spinach ferredoxin, respectively. This
  work was supported by grants from The Royal Society and the Biotechnology and Biological
  Sciences Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Paul
  full_name: Burrows, Paul
  last_name: Burrows
- first_name: Peter
  full_name: Nixon, Peter
  last_name: Nixon
citation:
  ama: 'Sazanov LA, Burrows P, Nixon P. The plastid ndh genes code for an NADH-specific
    dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes.
    <i>PNAS</i>. 1998;95(3):1319-1324. doi:<a href="https://doi.org/10.1073/pnas.95.3.1319">10.1073/pnas.95.3.1319</a>'
  apa: 'Sazanov, L. A., Burrows, P., &#38; Nixon, P. (1998). The plastid ndh genes
    code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from
    pea thylakoid membranes. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.95.3.1319">https://doi.org/10.1073/pnas.95.3.1319</a>'
  chicago: 'Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “The Plastid Ndh Genes
    Code for an NADH-Specific Dehydrogenase: Isolation of a Complex I Analogue from
    Pea Thylakoid Membranes.” <i>PNAS</i>. National Academy of Sciences, 1998. <a
    href="https://doi.org/10.1073/pnas.95.3.1319">https://doi.org/10.1073/pnas.95.3.1319</a>.'
  ieee: 'L. A. Sazanov, P. Burrows, and P. Nixon, “The plastid ndh genes code for
    an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid
    membranes,” <i>PNAS</i>, vol. 95, no. 3. National Academy of Sciences, pp. 1319–1324,
    1998.'
  ista: 'Sazanov LA, Burrows P, Nixon P. 1998. The plastid ndh genes code for an NADH-specific
    dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes.
    PNAS. 95(3), 1319–1324.'
  mla: 'Sazanov, Leonid A., et al. “The Plastid Ndh Genes Code for an NADH-Specific
    Dehydrogenase: Isolation of a Complex I Analogue from Pea Thylakoid Membranes.”
    <i>PNAS</i>, vol. 95, no. 3, National Academy of Sciences, 1998, pp. 1319–24,
    doi:<a href="https://doi.org/10.1073/pnas.95.3.1319">10.1073/pnas.95.3.1319</a>.'
  short: L.A. Sazanov, P. Burrows, P. Nixon, PNAS 95 (1998) 1319–1324.
date_created: 2018-12-11T11:54:54Z
date_published: 1998-02-03T00:00:00Z
date_updated: 2022-09-01T13:47:05Z
day: '03'
doi: 10.1073/pnas.95.3.1319
extern: '1'
external_id:
  pmid:
  - '9448329 '
intvolume: '        95'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://europepmc.org/article/pmc/18756
month: '02'
oa: 1
oa_version: None
page: 1319 - 1324
pmid: 1
publication: PNAS
publication_identifier:
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '5130'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of
  a complex I analogue from pea thylakoid membranes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 95
year: '1998'
...
---
_id: '1449'
abstract:
- lang: eng
  text: In this paper we consider a canonical compactification of M, the moduli space
    of stable Higgs bundles with fixed determinant of odd degree over a Riemann surface
    Σ, producing a projective variety M̄ = M ∪ Z. We give a detailed study of the
    spaces M̄, Z and M. In doing so we reprove some assertions of Laumon and Thaddeus
    on the nilpotent cone.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
citation:
  ama: Hausel T. Compactification of moduli of Higgs bundles. <i>Journal fur die Reine
    und Angewandte Mathematik</i>. 1998;1998(503):169-192. doi:<a href="https://doi.org/10.1515/crll.1998.096">10.1515/crll.1998.096</a>
  apa: Hausel, T. (1998). Compactification of moduli of Higgs bundles. <i>Journal
    Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter. <a href="https://doi.org/10.1515/crll.1998.096">https://doi.org/10.1515/crll.1998.096</a>
  chicago: Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” <i>Journal
    Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter, 1998. <a href="https://doi.org/10.1515/crll.1998.096">https://doi.org/10.1515/crll.1998.096</a>.
  ieee: T. Hausel, “Compactification of moduli of Higgs bundles,” <i>Journal fur die
    Reine und Angewandte Mathematik</i>, vol. 1998, no. 503. Walter de Gruyter, pp.
    169–192, 1998.
  ista: Hausel T. 1998. Compactification of moduli of Higgs bundles. Journal fur die
    Reine und Angewandte Mathematik. 1998(503), 169–192.
  mla: Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” <i>Journal Fur
    Die Reine Und Angewandte Mathematik</i>, vol. 1998, no. 503, Walter de Gruyter,
    1998, pp. 169–92, doi:<a href="https://doi.org/10.1515/crll.1998.096">10.1515/crll.1998.096</a>.
  short: T. Hausel, Journal Fur Die Reine Und Angewandte Mathematik 1998 (1998) 169–192.
date_created: 2018-12-11T11:52:05Z
date_published: 1998-10-01T00:00:00Z
date_updated: 2022-09-01T13:51:07Z
day: '01'
doi: 10.1515/crll.1998.096
extern: '1'
external_id:
  arxiv:
  - math/9804083
intvolume: '      1998'
issue: '503'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math/9804083
month: '10'
oa: 1
oa_version: Preprint
page: 169 - 192
publication: Journal fur die Reine und Angewandte Mathematik
publication_identifier:
  issn:
  - 1435-5345
publication_status: published
publisher: Walter de Gruyter
publist_id: '5746'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Compactification of moduli of Higgs bundles
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1998
year: '1998'
...
---
_id: '1450'
abstract:
- lang: eng
  text: In this paper we consider the topological side of a problem which is the analogue
    of Sen's S-duality testing conjecture for Hitchin's moduli space M of rank 2 stable
    Higgs bundles of fixed determinant of odd degree over a Riemann surface ∑. We
    prove that all intersection numbers in the compactly supported cohomology of M
    vanish, i.e. &quot;there are no topological L2 harmonic forms on M&quot;. This
    result generalizes the well known vanishing of the Euler characteristic of the
    moduli space of rank 2 stable bundles N of fixed determinant of odd degree over
    ∑. Our proof shows that the vanishing of all intersection numbers of H* cpt(M)
    is given by relations analogous to the Mumford relations in the cohomology ring
    of N.
acknowledgement: "First of all I would like to thank my supervisor Nigel Hitchin for
  suggesting Problem 1, and for his help and \r\n encouragement. I am grateful to
  Michael Thaddeus for his inspiring paper [Thai], enlightening communications and
  his constant interest in my work. I am also indebted to Manfred Lehn for the idea
  of the proof of Theorem 6.2. I have found\r\nconversations with Michael Atiyah,
  Frances Kirwan and Graeme Segal very stimulating. I thank the Mathematical Institute
  and St. Catherine's College, Oxford for their hospitality during the preparation
  of this work. Finally I thank Trinity College, Cambridge for financial support."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
citation:
  ama: Hausel T. Vanishing of intersection numbers on the moduli space of Higgs bundles.
    <i>Advances in Theoretical and Mathematical Physics</i>. 1998;2(5):1011-1040.
    doi:<a href="https://doi.org/10.4310/ATMP.1998.v2.n5.a3">10.4310/ATMP.1998.v2.n5.a3</a>
  apa: Hausel, T. (1998). Vanishing of intersection numbers on the moduli space of
    Higgs bundles. <i>Advances in Theoretical and Mathematical Physics</i>. International
    Press. <a href="https://doi.org/10.4310/ATMP.1998.v2.n5.a3">https://doi.org/10.4310/ATMP.1998.v2.n5.a3</a>
  chicago: Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of
    Higgs Bundles.” <i>Advances in Theoretical and Mathematical Physics</i>. International
    Press, 1998. <a href="https://doi.org/10.4310/ATMP.1998.v2.n5.a3">https://doi.org/10.4310/ATMP.1998.v2.n5.a3</a>.
  ieee: T. Hausel, “Vanishing of intersection numbers on the moduli space of Higgs
    bundles,” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 2, no.
    5. International Press, pp. 1011–1040, 1998.
  ista: Hausel T. 1998. Vanishing of intersection numbers on the moduli space of Higgs
    bundles. Advances in Theoretical and Mathematical Physics. 2(5), 1011–1040.
  mla: Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of Higgs
    Bundles.” <i>Advances in Theoretical and Mathematical Physics</i>, vol. 2, no.
    5, International Press, 1998, pp. 1011–40, doi:<a href="https://doi.org/10.4310/ATMP.1998.v2.n5.a3">10.4310/ATMP.1998.v2.n5.a3</a>.
  short: T. Hausel, Advances in Theoretical and Mathematical Physics 2 (1998) 1011–1040.
date_created: 2018-12-11T11:52:06Z
date_published: 1998-09-01T00:00:00Z
date_updated: 2022-09-01T14:09:49Z
day: '01'
doi: 10.4310/ATMP.1998.v2.n5.a3
extern: '1'
external_id:
  arxiv:
  - math/9805071
intvolume: '         2'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math/9805071
month: '09'
oa: 1
oa_version: Preprint
page: 1011 - 1040
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
  issn:
  - 1095-0761
publication_status: published
publisher: International Press
publist_id: '5747'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Vanishing of intersection numbers on the moduli space of Higgs bundles
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '1998'
...
---
_id: '6160'
abstract:
- lang: eng
  text: Natural isolates of C. elegans exhibit either solitary or social feeding behavior.
    Solitary foragers move slowly on a bacterial lawn and disperse across it, while
    social foragers move rapidly on bacteria and aggregate together. A loss-of-function
    mutation in the npr-1 gene, which encodes a predicted G protein–coupled receptor
    similar to neuropeptide Y receptors, causes a solitary strain to take on social
    behavior. Two isoforms of NPR-1 that differ at a single residue occur in the wild.
    One isoform, NPR-1 215F, is found exclusively in social strains, while the other
    isoform, NPR-1 215V, is found exclusively in solitary strains. An NPR-1 215V transgene
    can induce solitary feeding behavior in a wild social strain. Thus, isoforms of
    a putative neuropeptide receptor generate natural variation in C. elegans feeding
    behavior.
author:
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Cornelia I
  full_name: Bargmann, Cornelia I
  last_name: Bargmann
citation:
  ama: de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog
    modifies social behavior and food response in C. elegans. <i>Cell</i>. 1998;94(5):679-689.
    doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a>
  apa: de Bono, M., &#38; Bargmann, C. I. (1998). Natural variation in a neuropeptide
    Y receptor homolog modifies social behavior and food response in C. elegans. <i>Cell</i>.
    Elsevier. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a>
  chicago: Bono, Mario de, and Cornelia I Bargmann. “Natural Variation in a Neuropeptide
    Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.”
    <i>Cell</i>. Elsevier, 1998. <a href="https://doi.org/10.1016/s0092-8674(00)81609-8">https://doi.org/10.1016/s0092-8674(00)81609-8</a>.
  ieee: M. de Bono and C. I. Bargmann, “Natural variation in a neuropeptide Y receptor
    homolog modifies social behavior and food response in C. elegans,” <i>Cell</i>,
    vol. 94, no. 5. Elsevier, pp. 679–689, 1998.
  ista: de Bono M, Bargmann CI. 1998. Natural variation in a neuropeptide Y receptor
    homolog modifies social behavior and food response in C. elegans. Cell. 94(5),
    679–689.
  mla: de Bono, Mario, and Cornelia I. Bargmann. “Natural Variation in a Neuropeptide
    Y Receptor Homolog Modifies Social Behavior and Food Response in C. Elegans.”
    <i>Cell</i>, vol. 94, no. 5, Elsevier, 1998, pp. 679–89, doi:<a href="https://doi.org/10.1016/s0092-8674(00)81609-8">10.1016/s0092-8674(00)81609-8</a>.
  short: M. de Bono, C.I. Bargmann, Cell 94 (1998) 679–689.
date_created: 2019-03-21T10:32:06Z
date_published: 1998-09-04T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '04'
doi: 10.1016/s0092-8674(00)81609-8
extern: '1'
external_id:
  pmid:
  - '9741632'
intvolume: '        94'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 679-689
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Natural variation in a neuropeptide Y receptor homolog modifies social behavior
  and food response in C. elegans
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 94
year: '1998'
...
---
_id: '11680'
abstract:
- lang: eng
  text: 'We present a model for edge updates with restricted randomness in dynamic
    graph algorithms and a general technique for analyzing the expected running time
    of an update operation. This model is able to capture the average case in many
    applications, since (1) it allows restrictions on the set of edges which can be
    used for insertions and (2) the type (insertion or deletion) of each update operation
    is arbitrary, i.e., not random. We use our technique to analyze existing and new
    dynamic algorithms for the following problems: maximum cardinality matching, minimum
    spanning forest, connectivity, 2-edge connectivity, k -edge connectivity, k -vertex
    connectivity, and bipartiteness. Given a random graph G with m 0 edges and n vertices
    and a sequence of l update operations such that the graph contains m i edges after
    operation i , the expected time for performing the updates for any l is O(llogn+∑li=1n/m−−√i)
    in the case of minimum spanning forests, connectivity, 2-edge connectivity, and
    bipartiteness. The expected time per update operation is O(n) in the case of maximum
    matching. We also give improved bounds for k -edge and k -vertex connectivity.
    Additionally we give an insertions-only algorithm for maximum cardinality matching
    with worst-case O(n) amortized time per insertion.'
acknowledgement: The authors would like to thank Emo Welzl for helpful discussions.
article_processing_charge: No
article_type: original
author:
- first_name: D.
  full_name: Alberts, D.
  last_name: Alberts
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: Alberts D, Henzinger MH. Average-case analysis of dynamic graph algorithms.
    <i>Algorithmica</i>. 1998;20:31-60. doi:<a href="https://doi.org/10.1007/pl00009186">10.1007/pl00009186</a>
  apa: Alberts, D., &#38; Henzinger, M. H. (1998). Average-case analysis of dynamic
    graph algorithms. <i>Algorithmica</i>. Springer Nature. <a href="https://doi.org/10.1007/pl00009186">https://doi.org/10.1007/pl00009186</a>
  chicago: Alberts, D., and Monika H Henzinger. “Average-Case Analysis of Dynamic
    Graph Algorithms.” <i>Algorithmica</i>. Springer Nature, 1998. <a href="https://doi.org/10.1007/pl00009186">https://doi.org/10.1007/pl00009186</a>.
  ieee: D. Alberts and M. H. Henzinger, “Average-case analysis of dynamic graph algorithms,”
    <i>Algorithmica</i>, vol. 20. Springer Nature, pp. 31–60, 1998.
  ista: Alberts D, Henzinger MH. 1998. Average-case analysis of dynamic graph algorithms.
    Algorithmica. 20, 31–60.
  mla: Alberts, D., and Monika H. Henzinger. “Average-Case Analysis of Dynamic Graph
    Algorithms.” <i>Algorithmica</i>, vol. 20, Springer Nature, 1998, pp. 31–60, doi:<a
    href="https://doi.org/10.1007/pl00009186">10.1007/pl00009186</a>.
  short: D. Alberts, M.H. Henzinger, Algorithmica 20 (1998) 31–60.
date_created: 2022-07-28T06:50:51Z
date_published: 1998-01-01T00:00:00Z
date_updated: 2023-02-21T16:33:27Z
day: '01'
doi: 10.1007/pl00009186
extern: '1'
intvolume: '        20'
keyword:
- Dynamic graph algorithm
- Average-case analysis
- Minimum spanning forest
- Connectivity
- Bipartiteness
- Maximum matching.
language:
- iso: eng
month: '01'
oa_version: None
page: 31-60
publication: Algorithmica
publication_identifier:
  eissn:
  - 1432-0541
  issn:
  - 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '11928'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Average-case analysis of dynamic graph algorithms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '1998'
...
---
_id: '11681'
abstract:
- lang: eng
  text: We prove lower bounds on the complexity of maintaining fully dynamic k -edge
    or k -vertex connectivity in plane graphs and in (k-1) -vertex connected graphs.
    We show an amortized lower bound of Ω (log n / {k (log log n} + log b)) per edge
    insertion, deletion, or query operation in the cell probe model, where b is the
    word size of the machine and n is the number of vertices in G . We also show an
    amortized lower bound of Ω (log n /(log log n + log b)) per operation for fully
    dynamic planarity testing in embedded graphs. These are the first lower bounds
    for fully dynamic connectivity problems.
acknowledgement: .
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: M. L.
  full_name: Fredman, M. L.
  last_name: Fredman
citation:
  ama: Henzinger MH, Fredman ML. Lower bounds for fully dynamic connectivity problems
    in graphs. <i>Algorithmica</i>. 1998;22(3):351-362. doi:<a href="https://doi.org/10.1007/pl00009228">10.1007/pl00009228</a>
  apa: Henzinger, M. H., &#38; Fredman, M. L. (1998). Lower bounds for fully dynamic
    connectivity problems in graphs. <i>Algorithmica</i>. Springer Nature. <a href="https://doi.org/10.1007/pl00009228">https://doi.org/10.1007/pl00009228</a>
  chicago: Henzinger, Monika H, and M. L. Fredman. “Lower Bounds for Fully Dynamic
    Connectivity Problems in Graphs.” <i>Algorithmica</i>. Springer Nature, 1998.
    <a href="https://doi.org/10.1007/pl00009228">https://doi.org/10.1007/pl00009228</a>.
  ieee: M. H. Henzinger and M. L. Fredman, “Lower bounds for fully dynamic connectivity
    problems in graphs,” <i>Algorithmica</i>, vol. 22, no. 3. Springer Nature, pp.
    351–362, 1998.
  ista: Henzinger MH, Fredman ML. 1998. Lower bounds for fully dynamic connectivity
    problems in graphs. Algorithmica. 22(3), 351–362.
  mla: Henzinger, Monika H., and M. L. Fredman. “Lower Bounds for Fully Dynamic Connectivity
    Problems in Graphs.” <i>Algorithmica</i>, vol. 22, no. 3, Springer Nature, 1998,
    pp. 351–62, doi:<a href="https://doi.org/10.1007/pl00009228">10.1007/pl00009228</a>.
  short: M.H. Henzinger, M.L. Fredman, Algorithmica 22 (1998) 351–362.
date_created: 2022-07-28T06:58:36Z
date_published: 1998-11-01T00:00:00Z
date_updated: 2022-09-12T09:03:36Z
day: '01'
doi: 10.1007/pl00009228
extern: '1'
intvolume: '        22'
issue: '3'
keyword:
- Dynamic planarity testing
- Dynamic connectivity testing
- Lower bounds
- Cell probe model
language:
- iso: eng
month: '11'
oa_version: None
page: 351-362
publication: Algorithmica
publication_identifier:
  eissn:
  - 1432-0541
  issn:
  - 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lower bounds for fully dynamic connectivity problems in graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '1998'
...
---
_id: '11682'
abstract:
- lang: eng
  text: We consider the parametric minimum spanning tree problem, in which we are
    given a graph with edge weights that are linear functions of a parameter /spl
    lambda/ and wish to compute the sequence of minimum spanning trees generated as
    /spl lambda/ varies. We also consider the kinetic minimum spanning tree problem,
    in which /spl lambda/ represents time and the graph is subject in addition to
    changes such as edge insertions, deletions, and modifications of the weight functions
    as time progresses. We solve both problems in time O(n/sup 2/3/log/sup 4/3/) per
    combinatorial change in the tree (or randomized O(n/sup 2/3/log/sup 4/3/ n) per
    change). Our time bounds reduce to O(n/sup 1/2/log/sup 3/2/ n) per change (O(n/sup
    1/2/log n) randomized) for planar graphs or other minor-closed families of graphs,
    and O(n/sup 1/4/log/sup 3/2/ n) per change (O(n/sup 1/4/ log n) randomized) for
    planar graphs with weight changes but no insertions or deletions.
article_processing_charge: No
author:
- first_name: P. K.
  full_name: Agarwal, P. K.
  last_name: Agarwal
- first_name: D.
  full_name: EppsteinL. J. Guibas, D.
  last_name: EppsteinL. J. Guibas
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: 'Agarwal PK, EppsteinL. J. Guibas D, Henzinger MH. Parametric and kinetic minimum
    spanning trees. In: <i>Proceedings of the 39th Annual Symposium on Foundations
    of Computer Science</i>. ; 1998:596-605. doi:<a href="https://doi.org/10.1109/SFCS.1998.743510">10.1109/SFCS.1998.743510</a>'
  apa: Agarwal, P. K., EppsteinL. J. Guibas, D., &#38; Henzinger, M. H. (1998). Parametric
    and kinetic minimum spanning trees. In <i>Proceedings of the 39th Annual Symposium
    on Foundations of Computer Science</i> (pp. 596–605). Palo Alto, CA, United States.
    <a href="https://doi.org/10.1109/SFCS.1998.743510">https://doi.org/10.1109/SFCS.1998.743510</a>
  chicago: Agarwal, P. K., D. EppsteinL. J. Guibas, and Monika H Henzinger. “Parametric
    and Kinetic Minimum Spanning Trees.” In <i>Proceedings of the 39th Annual Symposium
    on Foundations of Computer Science</i>, 596–605, 1998. <a href="https://doi.org/10.1109/SFCS.1998.743510">https://doi.org/10.1109/SFCS.1998.743510</a>.
  ieee: P. K. Agarwal, D. EppsteinL. J. Guibas, and M. H. Henzinger, “Parametric and
    kinetic minimum spanning trees,” in <i>Proceedings of the 39th Annual Symposium
    on Foundations of Computer Science</i>, Palo Alto, CA, United States, 1998, pp.
    596–605.
  ista: Agarwal PK, EppsteinL. J. Guibas D, Henzinger MH. 1998. Parametric and kinetic
    minimum spanning trees. Proceedings of the 39th Annual Symposium on Foundations
    of Computer Science. Annual IEEE Symposium on Foundations of Computer Science,
    596–605.
  mla: Agarwal, P. K., et al. “Parametric and Kinetic Minimum Spanning Trees.” <i>Proceedings
    of the 39th Annual Symposium on Foundations of Computer Science</i>, 1998, pp.
    596–605, doi:<a href="https://doi.org/10.1109/SFCS.1998.743510">10.1109/SFCS.1998.743510</a>.
  short: P.K. Agarwal, D. EppsteinL. J. Guibas, M.H. Henzinger, in:, Proceedings of
    the 39th Annual Symposium on Foundations of Computer Science, 1998, pp. 596–605.
conference:
  end_date: 1998-11-11
  location: Palo Alto, CA, United States
  name: Annual IEEE Symposium on Foundations of Computer Science
  start_date: 1998-11-08
date_created: 2022-07-28T07:21:34Z
date_published: 1998-09-01T00:00:00Z
date_updated: 2023-02-09T11:28:52Z
day: '01'
doi: 10.1109/SFCS.1998.743510
extern: '1'
language:
- iso: eng
month: '09'
oa_version: None
page: 596-605
publication: Proceedings of the 39th Annual Symposium on Foundations of Computer Science
publication_identifier:
  isbn:
  - 0-8186-9172-7
  issn:
  - 0272-5428
publication_status: published
quality_controlled: '1'
scopus_import: '1'
status: public
title: Parametric and kinetic minimum spanning trees
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1998'
...
