---
_id: '2864'
abstract:
- lang: eng
text: Using an electrospray tandem mass spectrometer as a concentration-sensitive
detector, a method has been developed to quantify femtomole amounts of plant growth
regulators (i.e. isoprenoid type cytokinins, zeatin, dihydrozeatin, isopentenyladenine
and their respective riboside and glucoside analogues) and the second messenger
adenosine 3':5'-cyclic monophosphate (3':5'-cAMP). Miniaturisation of the chromatographic
setup using capillary high performance liquid chromatographic (HPLC) ion spray
mass spectrometry increased the sensitivity to the low femtomole region. Application
of automated capillary column switching allowed the introduction of large injection
volumes into the HPLC system. Aliquots (25 μL) were injected into one dimension
of the HPLC set-up and stacked onto a micro pre-column. By means of mobile phase
switching the pre-column was back-flushed to introduce the analytes onto the analytical
column. For cytokinin analysis positive electrospray ionisation was used and resulted
in 2.5-25 fmol detection limits. Cyclic nucleotides were separated under ion-pair
conditions using tetrabutyl ammonium bromide as ion-pair reagent and were detected
under negative electrospray ionisation conditions. Here a 25 fmol detection limit
was determined. Following this approach, cytokinins and 3':5'-cAMP extracted from
only mg amounts of apical shoot meristem and chloroplasts obtained from Nicotiana
tabacum cv. Petit Havana SR1 were identified and quantified.
acknowledgement: The authors wish to thank J. Dupon for technical and logisticalassistance.
The authors also wish to thank the FWO-Vlaanderen/lotto (grant 32013394), the Flemish government (GOA-action) and the
Grant Agency of the Czech Republic (grant 206/96/K188) for financial support.
article_processing_charge: No
article_type: original
author:
- first_name: Erwin
full_name: Witters, Erwin
last_name: Witters
- first_name: Koen
full_name: Vanhoutte, Koen
last_name: Vanhoutte
- first_name: Walter
full_name: Dewitte, Walter
last_name: Dewitte
- first_name: Ivana
full_name: Macháčková, Ivana
last_name: Macháčková
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Walter
full_name: Van Dongen, Walter
last_name: Van Dongen
- first_name: Eddy
full_name: Esmans, Eddy
last_name: Esmans
- first_name: Henri
full_name: Van Onckelen, Henri
last_name: Van Onckelen
citation:
ama: Witters E, Vanhoutte K, Dewitte W, et al. Analysis of cyclic nucleotides and
cytokinins in minute plant samples using phase system switching capillary electrospray
liquid chromatography tandem mass spectrometry. Phytochemical Analysis.
1999;10(3):143-151. doi:10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
apa: Witters, E., Vanhoutte, K., Dewitte, W., Macháčková, I., Benková, E., Van Dongen,
W., … Van Onckelen, H. (1999). Analysis of cyclic nucleotides and cytokinins in
minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry. Phytochemical Analysis. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
chicago: Witters, Erwin, Koen Vanhoutte, Walter Dewitte, Ivana Macháčková, Eva Benková,
Walter Van Dongen, Eddy Esmans, and Henri Van Onckelen. “Analysis of Cyclic Nucleotides
and Cytokinins in Minute Plant Samples Using Phase System Switching Capillary
Electrospray Liquid Chromatography Tandem Mass Spectrometry.” Phytochemical
Analysis. Wiley-Blackwell, 1999. https://doi.org/10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G.
ieee: E. Witters et al., “Analysis of cyclic nucleotides and cytokinins in
minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry,” Phytochemical Analysis, vol.
10, no. 3. Wiley-Blackwell, pp. 143–151, 1999.
ista: Witters E, Vanhoutte K, Dewitte W, Macháčková I, Benková E, Van Dongen W,
Esmans E, Van Onckelen H. 1999. Analysis of cyclic nucleotides and cytokinins
in minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry. Phytochemical Analysis. 10(3), 143–151.
mla: Witters, Erwin, et al. “Analysis of Cyclic Nucleotides and Cytokinins in Minute
Plant Samples Using Phase System Switching Capillary Electrospray Liquid Chromatography
Tandem Mass Spectrometry.” Phytochemical Analysis, vol. 10, no. 3, Wiley-Blackwell,
1999, pp. 143–51, doi:10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G.
short: E. Witters, K. Vanhoutte, W. Dewitte, I. Macháčková, E. Benková, W. Van Dongen,
E. Esmans, H. Van Onckelen, Phytochemical Analysis 10 (1999) 143–151.
date_created: 2018-12-11T12:00:00Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2022-09-09T09:09:22Z
day: '01'
doi: 10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 143 - 151
publication: Phytochemical Analysis
publication_identifier:
issn:
- 0958-0344
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of cyclic nucleotides and cytokinins in minute plant samples using
phase system switching capillary electrospray liquid chromatography tandem mass
spectrometry
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1999'
...
---
_id: '2865'
abstract:
- lang: eng
text: 'Although cytokinins (CKs) affect a number of processes connected with chloroplasts,
it has never been rigorously proven that chloroplasts contain CKs. We isolated
intact chloroplasts from tobacco (Nicotiana tabacum L. cv SR1) and wheat (Triticum
aestivum L. cv Ritmo) leaves and determined their CKs by liquid chromatography/tandem
mass spectroscopy. Chloroplasts from both species contained a whole spectrum of
CKs, including free bases (zeatin and isopentenyladenine), ribosides (zeatin riboside,
and isopentenyladenosine), ribotides (isopentenyladenosine-5′-monophosphate, zeatin
riboside-5′-monophosphate, and dihydrozeatin riboside-5′-monophosphate), and N-glucosides
(zeatin-N 9-glucoside, dihydrozeatin-N 9-glucoside, zeatin-N 7-glucoside, and
isopentenyladenine-N-glucosides). In chloroplasts there was a moderately higher
relative amount of bases, ribosides, and ribotides than in leaves, and a significantly
increased level ofN 9-glucosides of zeatin and dihydrozeatin. Tobacco and wheat
chloroplasts were prepared from leaves at the end of either a dark or light period.
After a dark period, chloroplasts accumulated more CKs than after a light period.
The differences were moderate for free bases and ribosides, but highly significant
for glucosides. Tobacco chloroplasts from dark-treated leaves contained zeatin
riboside-O-glucoside and dihydrozeatin riboside-O-glucoside, as well as a relatively
high CK oxidase activity. These data show that chloroplasts contain a whole spectrum
of CKs and the enzymatic activity necessary for their metabolism. '
acknowledgement: The authors thank Prof. Dennis Baker (Wye College, London) and Dr.
Laura Zonia (Institute of Experimental Botany, Prague) for language correction of
the manuscript and Prof. Miroslav Kamínek (Institute of Experimental Botany, Prague)
for critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Erwin
full_name: Witters, Erwin
last_name: Witters
- first_name: Walter
full_name: Van Dongen, Walter
last_name: Van Dongen
- first_name: Jan
full_name: Kolář, Jan
last_name: Kolář
- first_name: Václav
full_name: Motyka, Václav
last_name: Motyka
- first_name: Břetislav
full_name: Brzobohatý, Břetislav
last_name: Brzobohatý
- first_name: Henri
full_name: Van Onckelen, Henri
last_name: Van Onckelen
- first_name: Ivana
full_name: Macháčková, Ivana
last_name: Macháčková
citation:
ama: Benková E, Witters E, Van Dongen W, et al. Cytokinins in tobacco and wheat
chloroplasts. Occurrence and changes due to light/dark treatment. Plant Physiology.
1999;121(1):245-251. doi:10.1104/pp.121.1.245
apa: Benková, E., Witters, E., Van Dongen, W., Kolář, J., Motyka, V., Brzobohatý,
B., … Macháčková, I. (1999). Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. American Society
of Plant Biologists. https://doi.org/10.1104/pp.121.1.245
chicago: Benková, Eva, Erwin Witters, Walter Van Dongen, Jan Kolář, Václav Motyka,
Břetislav Brzobohatý, Henri Van Onckelen, and Ivana Macháčková. “Cytokinins in
Tobacco and Wheat Chloroplasts. Occurrence and Changes Due to Light/Dark Treatment.”
Plant Physiology. American Society of Plant Biologists, 1999. https://doi.org/10.1104/pp.121.1.245.
ieee: E. Benková et al., “Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment,” Plant Physiology, vol. 121, no.
1. American Society of Plant Biologists, pp. 245–251, 1999.
ista: Benková E, Witters E, Van Dongen W, Kolář J, Motyka V, Brzobohatý B, Van Onckelen
H, Macháčková I. 1999. Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. 121(1), 245–251.
mla: Benková, Eva, et al. “Cytokinins in Tobacco and Wheat Chloroplasts. Occurrence
and Changes Due to Light/Dark Treatment.” Plant Physiology, vol. 121, no.
1, American Society of Plant Biologists, 1999, pp. 245–51, doi:10.1104/pp.121.1.245.
short: E. Benková, E. Witters, W. Van Dongen, J. Kolář, V. Motyka, B. Brzobohatý,
H. Van Onckelen, I. Macháčková, Plant Physiology 121 (1999) 245–251.
date_created: 2018-12-11T12:00:00Z
date_published: 1999-09-01T00:00:00Z
date_updated: 2022-09-07T13:56:12Z
day: '01'
doi: 10.1104/pp.121.1.245
extern: '1'
external_id:
pmid:
- '10482680'
intvolume: ' 121'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59373/
month: '09'
oa: 1
oa_version: Published Version
page: 245 - 251
pmid: 1
publication: Plant Physiology
publication_identifier:
issn:
- 0032-0889
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3924'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinins in tobacco and wheat chloroplasts. Occurrence and changes due to
light/dark treatment
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 121
year: '1999'
...
---
_id: '3137'
abstract:
- lang: eng
text: This volume provides an overview of glutamate receptors and their role in
excitatory neurotransmission. It focusses on three aspects. First, it describes
the functional, molecular, and pharmacological properties of glutamate receptors
(AMPA, NMDA, and kainate receptors). Second, it gives a survey how these receptors
are involved in synaptic transmission at different glutamatergic synapses in the
mammalian CNS. Finally, it adresses how overactivation of glutamate receptors
can lead to excitotoxic cell death, and emphasizes the importance of glutamate
receptors as potential therapeutical targets. The chapters, written by leading
scientists, give accurate summaries of facets that have emerged recently in this
field. The book demonstrates the strength of a multidisciplinary approach involving
physiology, pharmacology, and molecular biology. It will be useful for other scientists
in and outside the field, lecturers and students at different educational levels.
alternative_title:
- Handbook of Experimental Pharmacology
article_processing_charge: No
citation:
ama: 'Jonas PM, Monyer H, eds. Ionotropic Glutamate Receptors in the CNS.
Vol 141. 1st ed. Berlin ; Heidelberg: Springer; 1999. doi:10.1007/978-3-662-08022-1'
apa: 'Jonas, P. M., & Monyer, H. (Eds.). (1999). Ionotropic Glutamate Receptors
in the CNS (1st ed., Vol. 141). Berlin ; Heidelberg: Springer. https://doi.org/10.1007/978-3-662-08022-1'
chicago: 'Jonas, Peter M, and Hannah Monyer, eds. Ionotropic Glutamate Receptors
in the CNS. 1st ed. Vol. 141. Berlin ; Heidelberg: Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1.'
ieee: 'P. M. Jonas and H. Monyer, Eds., Ionotropic Glutamate Receptors in the
CNS, 1st ed., vol. 141. Berlin ; Heidelberg: Springer, 1999.'
ista: 'Jonas PM, Monyer H eds. 1999. Ionotropic Glutamate Receptors in the CNS 1st
ed., Berlin ; Heidelberg: Springer, XXII, 535p.'
mla: Jonas, Peter M., and Hannah Monyer, editors. Ionotropic Glutamate Receptors
in the CNS. 1st ed., vol. 141, Springer, 1999, doi:10.1007/978-3-662-08022-1.
short: P.M. Jonas, H. Monyer, eds., Ionotropic Glutamate Receptors in the CNS, 1st
ed., Springer, Berlin ; Heidelberg, 1999.
date_created: 2018-12-11T12:01:36Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2021-12-22T11:13:43Z
day: '01'
doi: 10.1007/978-3-662-08022-1
edition: '1'
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
main_file_link:
- url: http://www.springer.com/biomed/pharmaceutical+science/book/978-3-540-66120-7
month: '01'
oa_version: None
page: XXII, 535
place: Berlin ; Heidelberg
publication_identifier:
eisbn:
- 978-3-662-08022-1
eissn:
- 1865-0325
isbn:
- 978-3-642-08539-0
issn:
- 0171-2004
publication_status: published
publisher: Springer
publist_id: '3560'
quality_controlled: '1'
status: public
title: Ionotropic Glutamate Receptors in the CNS
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 141
year: '1999'
...
---
_id: '3148'
abstract:
- lang: eng
text: Accurate proteolytic processing of neuropeptide and peptide hormone precursors
by members of the kexin/furin family of proteases is key to determining both the
identities and activities of signaling peptides. Here we identify amontillado
(amon), the Drosophila melanogaster homolog of the mammalian neuropeptide processing
protease PC2, and show that in contrast to vertebrate PC2, amontillado expression
undergoes extensive regulation in the nervous system during development. In situ
hybridization reveals that expression of amontillado is restricted to the final
stages of embryogenesis when it is found in anterior sensory structures and in
only 168 cells in the brain and ventral nerve cord. After larvae hatch from their
egg shells, the sensory structures and most cells in the CNS turn off or substantially
reduce amontillado expression, suggesting that amontillado plays a specific role
late in embryogenesis. Larvae lacking the chromosomal region containing amontillado
show no gross anatomical defects and respond to touch. However, such larvae show
a greatly reduced frequency of a hatching behavior of wild- type Drosophila in
which larvae swing their heads, scraping through the eggshell with their mouth
hooks. Ubiquitous expression of amontillado can restore near wild-type levels
of this behavior, whereas expression of amontillado with an alanine substitution
for the catalytic histidine cannot. These results suggest that amontillado expression
is regulated as part of a programmed modulation of neural signaling that controls
hatching behavior by producing specific neuropeptides in particular neurons at
an appropriate developmental time.
acknowledgement: This research was supported by National Institutes of Health Grant
GM39697 to R.S.F. D.S. was supported in part by National Institutes of Health training
Grant 2T32GM07599. We thank M. A. Krasnow and members of his laboratory, particularly
J. Jarecki, for technical guidance, encouragement, and stimulating scientific discussions.
We thank A. Maghbouleh and the Stanford Statistics Department Consulting Service
for help with statistical analysis. We thank G. Beitel, S. Dietrich, K. Guillemin,
D. Micklem, Y. Nakajima, and members of the Fuller and Krasnow laboratories for
comments on this manuscript. We thank M. Palazzolo for the use of theDrosophila
head cDNA library, D. Kiehart for the use of a Drosophila myosin antibody, and D.
Casso, F.-A. Ramirez-Weber, and T. B. Kornberg for use of the D/TM3SbKrGFP flies.
We thank A. R. Kidd, D. Tolla, and M. Bender and D. Casso, F.-A. Ramirez-Weber and
T. B. Kornberg for communication of results before publication
article_processing_charge: No
article_type: original
author:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
citation:
ama: Siekhaus DE, Fuller R. A role for amontillado the Drosophila homolog of the
neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 1999;19(16):6942-6954. doi:10.1523/jneurosci.19-16-06942.1999
apa: Siekhaus, D. E., & Fuller, R. (1999). A role for amontillado the Drosophila
homolog of the neuropeptide precursor processing protease PC2 in triggering hatching
behavior. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/jneurosci.19-16-06942.1999
chicago: Siekhaus, Daria E, and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/jneurosci.19-16-06942.1999.
ieee: D. E. Siekhaus and R. Fuller, “A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior,”
Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, pp.
6942–6954, 1999.
ista: Siekhaus DE, Fuller R. 1999. A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 19(16), 6942–6954.
mla: Siekhaus, Daria E., and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience,
1999, pp. 6942–54, doi:10.1523/jneurosci.19-16-06942.1999.
short: D.E. Siekhaus, R. Fuller, Journal of Neuroscience 19 (1999) 6942–6954.
date_created: 2018-12-11T12:01:40Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:48:41Z
day: '15'
doi: 10.1523/jneurosci.19-16-06942.1999
extern: '1'
external_id:
pmid:
- '10436051 '
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782853/
month: '08'
oa: 1
oa_version: Published Version
page: 6942 - 6954
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '3547'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A role for amontillado the Drosophila homolog of the neuropeptide precursor
processing protease PC2 in triggering hatching behavior
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3456'
abstract:
- lang: eng
text: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and
N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic
glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the
mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric
proteins, probably tetramers, formed by a variety of molecularly distinct subunits.
AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and
-D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional
molecular diversity of AMPARs is generated by alternative splicing of the flip-flop
module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily
assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants
have been identified for the NR1 subunit, and a new NR3 subunit has been discovered
recently. Considering all combinatorial possibilities, the molecular diversity
of glutamate-receptor channels is considerable (HOLLMANN, this volume).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Jean
full_name: Rossier, Jean
last_name: Rossier
citation:
ama: 'Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H,
eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339.
doi:10.1007/978-3-662-08022-1_9'
apa: Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants
controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In
P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS
(Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9
chicago: Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants
Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.”
In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and
Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9.
ieee: H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling
functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic
Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds.
Springer, 1999, pp. 309–339.
ista: 'Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate
Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.'
mla: Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties
of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors
in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer,
1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9.
short: H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic
Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339.
date_created: 2018-12-11T12:03:25Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:30:23Z
day: '01'
doi: 10.1007/978-3-662-08022-1_9
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 309 - 339
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular determinants controlling functional properties of AMPARs and NMDARs
in the mammalian CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3457'
abstract:
- lang: eng
text: Principal neurons and interneurons are the two main classes of cells in cortical
neuronal networks. Principal neurons (granule cells or pyramidal neurons) have
transregional axonal projections and release glutamate onto their postsynaptic
target cells. In contrast, interneurons have local, but often extensive, axonal
arborizations and use γ-aminobutyric acid (GABA) as a transmitter. Although interneurons
represent only approximately 10% of the neuronal population, they control the
electrical activity of the entire network (FREUND and BUZSÁKI 1996). Interneurons
forming inhibitory synapses on the somata or axon initial segments of their postsynaptic
target cells are thought to set the threshold of action potential initiation (MILES
et al. 1996) and can synchronize the collective activities of large principal
neuron ensembles (COBB et al. 1995). In contrast, interneurons establishing inhibitory
synapses mainly on dendrites could suppress dendritic Na+ or Ca2+ spikes (BUZSÁKI
et al. 1996; MILES et al. 1996) and, thus, regulate plasticity at glutamatergic
synapses in the cortex (DAVIES et al.1991).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Arnd
full_name: Roth, Arnd
last_name: Roth
- first_name: Birol
full_name: Taskin, Birol
last_name: Taskin
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Geiger J, Roth A, Taskin B, Jonas PM. Glutamate-mediated synaptic excitation
of cortical interneurons. In: Monyer H, Jonas PM, eds. Ionotropic Glutamate
Receptors in the CNS. Vol 141. Springer; 1999:363-398. doi:10.1007/978-3-662-08022-1_11'
apa: Geiger, J., Roth, A., Taskin, B., & Jonas, P. M. (1999). Glutamate-mediated
synaptic excitation of cortical interneurons. In H. Monyer & P. M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 363–398). Springer.
https://doi.org/10.1007/978-3-662-08022-1_11
chicago: Geiger, Jörg, Arnd Roth, Birol Taskin, and Peter M Jonas. “Glutamate-Mediated
Synaptic Excitation of Cortical Interneurons.” In Ionotropic Glutamate Receptors
in the CNS, edited by Hannah Monyer and Peter M Jonas, 141:363–98. Springer,
1999. https://doi.org/10.1007/978-3-662-08022-1_11.
ieee: J. Geiger, A. Roth, B. Taskin, and P. M. Jonas, “Glutamate-mediated synaptic
excitation of cortical interneurons,” in Ionotropic Glutamate Receptors in
the CNS, vol. 141, H. Monyer and P. M. Jonas, Eds. Springer, 1999, pp. 363–398.
ista: 'Geiger J, Roth A, Taskin B, Jonas PM. 1999.Glutamate-mediated synaptic excitation
of cortical interneurons. In: Ionotropic Glutamate Receptors in the CNS. Handbook
of experimental pharmacology, vol. 141, 363–398.'
mla: Geiger, Jörg, et al. “Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.”
Ionotropic Glutamate Receptors in the CNS, edited by Hannah Monyer and
Peter M Jonas, vol. 141, Springer, 1999, pp. 363–98, doi:10.1007/978-3-662-08022-1_11.
short: J. Geiger, A. Roth, B. Taskin, P.M. Jonas, in:, H. Monyer, P.M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 363–398.
date_created: 2018-12-11T12:03:26Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:25:46Z
day: '01'
doi: 10.1007/978-3-662-08022-1_11
editor:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 363 - 398
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2930'
quality_controlled: '1'
status: public
title: Glutamate-mediated synaptic excitation of cortical interneurons
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3515'
abstract:
- lang: eng
text: Oscillations in neuronal networks are assumed to serve various physiological
functions, from coordination of motor patterns to perceptual binding of sensory
information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus.
Extracellular and intracellular activity was recorded from the CA1 and subicular
regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane.
in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s)
occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast
increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed
by large-amplitude rhythmic waves and associated action potentials at gamma and
beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally
synchronous and terminated relatively abruptly without post-ictal depression.
Single-pulse stimulation of the commissural input could trigger afterdischarges,
but only at times when they were about to occur. Commissural stimulation evoked
inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus
triggered an afterdischarge, the inhibitory postsynaptic potential was absent
and the cells remained depolarized during most of the afterdischarge. Afterdischarges
were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal
activity in intact, drug-free rats also revealed periodic excitability changes
in the hippocampal network at 0.025 Hz. These findings indicate the presence of
an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced
afterdischarges in susceptible animals. We hypothesize that a transient failure
of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence
of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.
acknowledgement: This work was supported by the Academy of Finland (32391) and the
NIH (NS34994, MH54671).
article_processing_charge: No
article_type: original
author:
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Nina
full_name: Nurminen, Nina
last_name: Nurminen
- first_name: Riitta
full_name: Miettinen, Riitta
last_name: Miettinen
- first_name: Jouni
full_name: Sirviö, Jouni
last_name: Sirviö
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025
Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience.
1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X
apa: Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari,
J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X
chicago: Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell
Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025
Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience.
Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X.
ieee: M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier,
pp. 735–743, 1999.
ista: Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki
G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges
in Wistar rats. Neuroscience. 94(3), 735–743.
mla: Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal
Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier,
1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X.
short: M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari,
G. Buzsáki, Neuroscience 94 (1999) 735–743.
date_created: 2018-12-11T12:03:44Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-07T13:16:01Z
day: '01'
doi: 10.1016/S0306-4522(99)00367-X
extern: '1'
external_id:
pmid:
- '10579564'
intvolume: ' 94'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 735 - 743
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2870'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar
rats
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3519'
abstract:
- lang: eng
text: 'In contrast to sensory cortical areas of the brain, the relevant physiological
inputs to the hippocampus, leading to selective activation of pyramidal cells,
are largely unknown. Pyramidal cells are thought to be phasically activated by
spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural
`space clamp'' method, which involved the confinement of the actively running
animal in a defined position in space (running wheel) and kept sensory inputs
constant. Twelve percent of the recorded CA1 pyramidal cells were selectively
active while the rat was running in the wheel. Cell firing was specific to the
direction of running and disappeared after rotating the recording apparatus. The
discharge frequency of pyramidal cells and interneurons was sustained as long
as the rat ran continuously in the wheel. Furthermore, the discharge frequency
of pyramidal cells and interneurons increased with increasing running velocity,
even though the frequency of hippocampal theta waves remained constant. The discharge
frequency of some `wheel-related'' pyramidal cells could increase more than 10-fold
between 10 and 100 cm/s, whereas the firing rate of `non-wheel'' cells remained
constantly low. We hypothesize that: (i) a necessary condition for place-specific
discharge of hippocampal pyramidal cells is the presence of theta oscillation;
and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal
cells as long as theta activity is present.'
acknowledgement: We thank M. Recce for continuous support, A. Berthoz for advice,
K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand
C. King for his comments on the manuscript. This work was supportedby NIH (NS34994,
MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State
Fellowship (A.C.) and the Soros Foundation (A.C.)
article_processing_charge: No
article_type: original
author:
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal
pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal
of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x
apa: Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained
activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x
chicago: Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki.
“Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a
Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999.
https://doi.org/10.1046/j.1460-9568.1999.00446.x.
ieee: A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation
of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European
Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999.
ista: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of
hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European
Journal of Neuroscience. 11(1), 344–352.
mla: Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells
by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience,
vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x.
short: A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 344–352.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:09:08Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00446.x
extern: '1'
external_id:
pmid:
- '9987037'
intvolume: ' 11'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 344 - 352
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2867'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sustained activation of hippocampal pyramidal cells by ‘space clamping' in
a running wheel
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3539'
abstract:
- lang: eng
text: In the hippocampus, spatial representation of the environment has been suggested
to be coded by either the firing rate of pyramidal cell assemblies or the relative
timing of the action potentials during the theta EEG cycle. Here, we used a behavioural
`space clamp' method, which involved the confinement of the actively running animal
in a defined position in space (running wheel) to examine how `spatial' and other
inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons.
Nineteen per cent of the recorded CA1 pyramidal cells were selectively active
while the rat was running in the wheel in a given direction ('wheel' cells). Spatial
rotation of the apparatus showed that selective discharge of pyramidal cells in
the wheel was under the combined influence of distal and apparatus cues. During
steady running, both discharge rate and theta phase were constant. Rotation of
the wheel apparatus resulted in a shift of both firing rate and preferred theta
phase. The discharge frequency of `wheel' cells increased threefold (on average)
with increasing running velocity. In contrast, change in running speed had relatively
little effect on the theta phase-related discharge of `wheel' cells. Our findings
indicate that mechanisms that regulate rate and phase of spikes are overlapping
but not necessarily identical.
acknowledgement: 'We thank M. Recce for his comments on the manuscript. This work
wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.),
the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) '
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding
by hippocampal pyramidal neurons during ‘space clamping.’ European Journal
of Neuroscience. 1999;11(12):4373-4380. doi:10.1046/j.1460-9568.1999.00853.x
apa: Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Firing
rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00853.x
chicago: Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki.
“Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space
Clamping.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00853.x.
ieee: H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping,’” European
Journal of Neuroscience, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380,
1999.
ista: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal
of Neuroscience. 11(12), 4373–4380.
mla: Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal
Neurons during ‘Space Clamping.’” European Journal of Neuroscience, vol.
11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:10.1046/j.1460-9568.1999.00853.x.
short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 4373–4380.
date_created: 2018-12-11T12:03:51Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:45:36Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00853.x
extern: '1'
external_id:
pmid:
- '10594664 '
intvolume: ' 11'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 4373 - 4380
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2845'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rate and theta-phase coding by hippocampal pyramidal neurons during
‘space clamping’
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3554'
abstract:
- lang: eng
text: In computational simulation of coupled, multicomponent systems, it is frequently
necessary to transfer data between meshes that may differ in resolution, structure,
and discretization methodology. Typically, nodes from one mesh must be associated
with elements of another mesh. In this paper, we formulate mesh association as
a geometric problem and introduce two efficient mesh association algorithms. One
of these algorithms requires linear time in the worst case if the meshes are well
shaped and geometrically well aligned. Our formulation of the problem and our
algorithms are more general than previous work and can be applied to surface meshes
with curved elements.
article_processing_charge: No
author:
- first_name: Xiangmin
full_name: Jiao, Xiangmin
last_name: Jiao
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Heath, Michael
last_name: Heath
citation:
ama: 'Jiao X, Edelsbrunner H, Heath M. Mesh association: formulation and algorithms.
In: Proceedings of the 8th International Meshing Roundtable. Elsevier;
1999:75-82.'
apa: 'Jiao, X., Edelsbrunner, H., & Heath, M. (1999). Mesh association: formulation
and algorithms. In Proceedings of the 8th International Meshing Roundtable
(pp. 75–82). South Lake Tahoe, CA, United States of America: Elsevier.'
chicago: 'Jiao, Xiangmin, Herbert Edelsbrunner, and Michael Heath. “Mesh Association:
Formulation and Algorithms.” In Proceedings of the 8th International Meshing
Roundtable, 75–82. Elsevier, 1999.'
ieee: 'X. Jiao, H. Edelsbrunner, and M. Heath, “Mesh association: formulation and
algorithms,” in Proceedings of the 8th International Meshing Roundtable,
South Lake Tahoe, CA, United States of America, 1999, pp. 75–82.'
ista: 'Jiao X, Edelsbrunner H, Heath M. 1999. Mesh association: formulation and
algorithms. Proceedings of the 8th International Meshing Roundtable. IMR: International
Meshing Roundtable, 75–82.'
mla: 'Jiao, Xiangmin, et al. “Mesh Association: Formulation and Algorithms.” Proceedings
of the 8th International Meshing Roundtable, Elsevier, 1999, pp. 75–82.'
short: X. Jiao, H. Edelsbrunner, M. Heath, in:, Proceedings of the 8th International
Meshing Roundtable, Elsevier, 1999, pp. 75–82.
conference:
end_date: 1999-10-13
location: South Lake Tahoe, CA, United States of America
name: 'IMR: International Meshing Roundtable'
start_date: 1999-10-10
date_created: 2018-12-11T12:03:56Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-06T09:35:53Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.35.2959
month: '10'
oa_version: None
page: 75 - 82
publication: Proceedings of the 8th International Meshing Roundtable
publication_status: published
publisher: Elsevier
publist_id: '2831'
quality_controlled: '1'
status: public
title: 'Mesh association: formulation and algorithms'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1999'
...
---
_id: '3571'
alternative_title:
- Contemporary Mathematics
article_processing_charge: No
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sumanta
full_name: Guha, Sumanta
last_name: Guha
citation:
ama: 'Dey T, Edelsbrunner H, Guha S. Computational topology. In: Advances in
Discrete and Computational Geometry. Vol 223. American Mathematical Society;
1999:109-143.'
apa: Dey, T., Edelsbrunner, H., & Guha, S. (1999). Computational topology. In
Advances in Discrete and Computational Geometry (Vol. 223, pp. 109–143).
American Mathematical Society.
chicago: Dey, Tamal, Herbert Edelsbrunner, and Sumanta Guha. “Computational Topology.”
In Advances in Discrete and Computational Geometry, 223:109–43. American
Mathematical Society, 1999.
ieee: T. Dey, H. Edelsbrunner, and S. Guha, “Computational topology,” in Advances
in Discrete and Computational Geometry, vol. 223, American Mathematical Society,
1999, pp. 109–143.
ista: 'Dey T, Edelsbrunner H, Guha S. 1999.Computational topology. In: Advances
in Discrete and Computational Geometry. Contemporary Mathematics, vol. 223, 109–143.'
mla: Dey, Tamal, et al. “Computational Topology.” Advances in Discrete and Computational
Geometry, vol. 223, American Mathematical Society, 1999, pp. 109–43.
short: T. Dey, H. Edelsbrunner, S. Guha, in:, Advances in Discrete and Computational
Geometry, American Mathematical Society, 1999, pp. 109–143.
date_created: 2018-12-11T12:04:01Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-06T09:28:57Z
day: '01'
extern: '1'
intvolume: ' 223'
language:
- iso: eng
month: '01'
oa_version: None
page: 109 - 143
publication: Advances in Discrete and Computational Geometry
publication_identifier:
isbn:
- '9780821878149'
publication_status: published
publisher: American Mathematical Society
publist_id: '2814'
quality_controlled: '1'
status: public
title: Computational topology
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 223
year: '1999'
...
---
_id: '3582'
abstract:
- lang: eng
text: We study edge contractions in simplicial complexes and local conditions under
which they preserve the topological type. The conditions are based on a generalized
notion of boundary, which lends itself to defining a nested hierarchy of triangulable
spaces measuring the distance to being a manifold.
acknowledgement: The second author thanks Wolfgang Haken and Min Yan for interesting
discussions and Günter Ziegler for suggesting the knot construction in the triangulation
of the 3-sphere mentioned in Section 7.
article_processing_charge: No
article_type: original
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sumanta
full_name: Guha, Sumanta
last_name: Guha
- first_name: Dmitry
full_name: Nekhayev, Dmitry
last_name: Nekhayev
citation:
ama: Dey T, Edelsbrunner H, Guha S, Nekhayev D. Topology preserving edge contraction.
Publications de l’Institut Mathématique. 1999;66:23-45.
apa: Dey, T., Edelsbrunner, H., Guha, S., & Nekhayev, D. (1999). Topology preserving
edge contraction. Publications de l’Institut Mathématique. Mathematical
Institute, Serbian Academy of Sciences and Arts.
chicago: Dey, Tamal, Herbert Edelsbrunner, Sumanta Guha, and Dmitry Nekhayev. “Topology
Preserving Edge Contraction.” Publications de l’Institut Mathématique.
Mathematical Institute, Serbian Academy of Sciences and Arts, 1999.
ieee: T. Dey, H. Edelsbrunner, S. Guha, and D. Nekhayev, “Topology preserving edge
contraction,” Publications de l’Institut Mathématique, vol. 66. Mathematical
Institute, Serbian Academy of Sciences and Arts, pp. 23–45, 1999.
ista: Dey T, Edelsbrunner H, Guha S, Nekhayev D. 1999. Topology preserving edge
contraction. Publications de l’Institut Mathématique. 66, 23–45.
mla: Dey, Tamal, et al. “Topology Preserving Edge Contraction.” Publications
de l’Institut Mathématique, vol. 66, Mathematical Institute, Serbian Academy
of Sciences and Arts, 1999, pp. 23–45.
short: T. Dey, H. Edelsbrunner, S. Guha, D. Nekhayev, Publications de l’Institut
Mathématique 66 (1999) 23–45.
date_created: 2018-12-11T12:04:05Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-03-22T13:20:32Z
day: '01'
extern: '1'
intvolume: ' 66'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.emis.de/journals/PIMB/080/3.html
month: '01'
oa: 1
oa_version: None
page: 23 - 45
publication: Publications de l'Institut Mathématique
publication_identifier:
issn:
- 0350-1302
publication_status: published
publisher: Mathematical Institute, Serbian Academy of Sciences and Arts
publist_id: '2803'
quality_controlled: '1'
status: public
title: Topology preserving edge contraction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1999'
...
---
_id: '3625'
abstract:
- lang: eng
text: 'This article outlines theoretical models of clines in additive polygenic
traits, which are maintained by stabilizing selection towards a spatially varying
optimum. Clines in the trait mean can be accurately predicted, given knowledge
of the genetic variance. However, predicting the variance is difficult, because
it depends on genetic details. Changes in genetic variance arise from changes
in allele frequency, and in linkage disequilibria. Allele frequency changes dominate
when selection is weak relative to recombination, and when there are a moderate
number of loci. With a continuum of alleles, gene flow inflates the genetic variance
in the same way as a source of mutations of small effect. The variance can be
approximated by assuming a Gaussian distribution of allelic effects; with a sufficiently
steep cline, this is accurate even when mutation and selection alone are better
described by the ''House of Cards'' approximation. With just two alleles at each
locus, the phenotype changes in a similar way: the mean remains close to the optimum,
while the variance changes more slowly, and over a wider region. However, there
may be substantial cryptic divergence at the underlying loci. With strong selection
and many loci, linkage disequilibria are the main cause of changes in genetic
variance. Even for strong selection, the infinitesimal model can be closely approximated
by assuming a Gaussian distribution of breeding values. Linkage disequilibria
can generate a substantial increase in genetic variance, which is concentrated
at sharp gradients in trait means.'
acknowledgement: This work was supported by the Darwin Trust of Edinburgh, and by
grants MMI09726 from the BBSRC}EPSRC and GR3}11635 from the NERC. I would like to
thank R. Lande and M. Slatkin for their comments on an earlier incarnation of this
article, and Mark Kirkpatrick, Loeske Kruuk and Michael Turelli for their comments
on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Clines in polygenic traits. Genetical Research. 1999;74(3):223-236.
doi:10.1017/S001667239900422X
apa: Barton, N. H. (1999). Clines in polygenic traits. Genetical Research.
Cambridge University Press. https://doi.org/10.1017/S001667239900422X
chicago: Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research.
Cambridge University Press, 1999. https://doi.org/10.1017/S001667239900422X.
ieee: N. H. Barton, “Clines in polygenic traits,” Genetical Research, vol.
74, no. 3. Cambridge University Press, pp. 223–236, 1999.
ista: Barton NH. 1999. Clines in polygenic traits. Genetical Research. 74(3), 223–236.
mla: Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research,
vol. 74, no. 3, Cambridge University Press, 1999, pp. 223–36, doi:10.1017/S001667239900422X.
short: N.H. Barton, Genetical Research 74 (1999) 223–236.
date_created: 2018-12-11T12:04:18Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:10:35Z
day: '01'
doi: 10.1017/S001667239900422X
extern: '1'
external_id:
pmid:
- '10689800 '
intvolume: ' 74'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 223 - 236
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2758'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clines in polygenic traits
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 74
year: '1999'
...
---
_id: '3626'
abstract:
- lang: eng
text: There has recently been considerable debate over the relative importance of
selection against hybrids ("endogenous" selection) vs. adaptation to
different environments ("exogenous") in maintaining stable hybrid zones
and hence in speciation. Single-locus models of endogenous and exogenous viability
selection generate clines of similar shape, but the comparison has not been extended
to multilocus systems, which are both quantitatively and qualitatively very different
from the single-locus case. Here we develop an analytical multilocus model of
differential adaptation across an environmental transition and compare it to previous
heterozygote disadvantage models. We show that the shape of clines generated by
exogenous selection is indistinguishable from that generated by endogenous selection.
A stochastic simulation model is used to test the robustness of the analytical
description to the effects of drift and strong selection, and confirms the prediction
that pairwise linkage disequilibria are predominantly generated by migration.
However, although analytical predictions for the width of clines maintained by
heterozygote disadvantage fit well with the simulation results, those for environmental
adaptation are consistently too narrow; reasons for the discrepancy are discussed.
There is a smooth transition between a system in which a set of loci effectively
act independently of each other and one in which they act as a single nonrecombining
unit.
article_processing_charge: No
article_type: original
author:
- first_name: Loeske
full_name: Kruuk, Loeske
last_name: Kruuk
- first_name: Stuart
full_name: Baird, Stuart
last_name: Baird
- first_name: Katherine
full_name: Gale, Katherine
last_name: Gale
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kruuk L, Baird S, Gale K, Barton NH. A comparison of multilocus clines maintained
by environmental adaptation or by selection against hybrids. Genetics.
1999;153(4):1959-1971. doi:10.1093/genetics/153.4.1959
apa: Kruuk, L., Baird, S., Gale, K., & Barton, N. H. (1999). A comparison of
multilocus clines maintained by environmental adaptation or by selection against
hybrids. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/153.4.1959
chicago: Kruuk, Loeske, Stuart Baird, Katherine Gale, and Nicholas H Barton. “A
Comparison of Multilocus Clines Maintained by Environmental Adaptation or by Selection
against Hybrids.” Genetics. Genetics Society of America, 1999. https://doi.org/10.1093/genetics/153.4.1959.
ieee: L. Kruuk, S. Baird, K. Gale, and N. H. Barton, “A comparison of multilocus
clines maintained by environmental adaptation or by selection against hybrids,”
Genetics, vol. 153, no. 4. Genetics Society of America, pp. 1959–1971,
1999.
ista: Kruuk L, Baird S, Gale K, Barton NH. 1999. A comparison of multilocus clines
maintained by environmental adaptation or by selection against hybrids. Genetics.
153(4), 1959–1971.
mla: Kruuk, Loeske, et al. “A Comparison of Multilocus Clines Maintained by Environmental
Adaptation or by Selection against Hybrids.” Genetics, vol. 153, no. 4,
Genetics Society of America, 1999, pp. 1959–71, doi:10.1093/genetics/153.4.1959.
short: L. Kruuk, S. Baird, K. Gale, N.H. Barton, Genetics 153 (1999) 1959–1971.
date_created: 2018-12-11T12:04:19Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:06:02Z
day: '01'
doi: 10.1093/genetics/153.4.1959
extern: '1'
external_id:
pmid:
- '10581299'
intvolume: ' 153'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 1959 - 1971
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2757'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of multilocus clines maintained by environmental adaptation or
by selection against hybrids
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 153
year: '1999'
...
---
_id: '4014'
abstract:
- lang: eng
text: A new paradigm for designing smooth surfaces is described. A finite set of
points with weights specifies a closed surface in space referred to as skin. It
consists of one or more components, each tangent continuous and free of self-intersections
and intersections with other components. The skin varies continuously with the
weights and locations of the points, and the variation includes the possibility
of a topology change facilitated by the violation of tangent continuity at a single
point in space and time. Applications of the skin to molecular modeling and to
geometric deformation are discussed.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Deformable smooth surface design. Discrete & Computational
Geometry. 1999;21(1):87-115. doi:10.1007/PL00009412
apa: Edelsbrunner, H. (1999). Deformable smooth surface design. Discrete &
Computational Geometry. Springer. https://doi.org/10.1007/PL00009412
chicago: Edelsbrunner, Herbert. “Deformable Smooth Surface Design.” Discrete
& Computational Geometry. Springer, 1999. https://doi.org/10.1007/PL00009412.
ieee: H. Edelsbrunner, “Deformable smooth surface design,” Discrete & Computational
Geometry, vol. 21, no. 1. Springer, pp. 87–115, 1999.
ista: Edelsbrunner H. 1999. Deformable smooth surface design. Discrete & Computational
Geometry. 21(1), 87–115.
mla: Edelsbrunner, Herbert. “Deformable Smooth Surface Design.” Discrete &
Computational Geometry, vol. 21, no. 1, Springer, 1999, pp. 87–115, doi:10.1007/PL00009412.
short: H. Edelsbrunner, Discrete & Computational Geometry 21 (1999) 87–115.
date_created: 2018-12-11T12:06:26Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-06T09:02:23Z
day: '01'
doi: 10.1007/PL00009412
extern: '1'
intvolume: ' 21'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 87 - 115
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2115'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Deformable smooth surface design
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1999'
...
---
_id: '4204'
abstract:
- lang: eng
text: During the development of the zebrafish nervous system both noi, a zebrafish
pax2 homolog, and ace, a zebrafish fgf8 homolog, are required for development
of the midbrain and cerebellum. Here we describe a dominant mutation, aussicht
(aus), in which the expression of noi and ace is upregulated, In aus mutant embryos,
ace is upregulated at many sites in the embryo, while Itoi expression is only
upregulated in regions of the forebrain and midbrain which also express ace. Subsequent
to the alterations in noi and ace expression, aus mutants exhibit defects in the
differentiation of the forebrain, midbrain and eyes. Within the forebrain, the
formation of the anterior and postoptic commissures is delayed and the expression
of markers within the pretectal area is reduced. Within the midbrain, En and wnt1
expression is expanded. In heterozygous aus embryos, there is ectopic outgrowth
of neural retina in the temporal half of the eyes, whereas in putative homozygous
aus embryos, the ventral retina is reduced and the pigmented retinal epithelium
is expanded towards the midline, The observation that ans mutant embryos exhibit
widespread upregulation of ace raised the possibility that aus might represent
an allele of the ace gene itself. However, by crossing carriers for both aus and
ace, we were able to generate homozygous ace mutant embryos that also exhibited
the aus phenotype, This indicated that aus is not tightly linked to ace and is
unlikely to be a mutation directly affecting the ace locus. However, increased
Ace activity may underly many aspects of the aus phenotype and we show that the
upregulation of noi in the forebrain of aus mutants is partially dependent upon
functional Ace activity. Conversely, increased ace expression in the forebrain
of arcs mutants is not dependent upon functional Noi activity. We conclude that
aus represents a mutation involving a locus normally required for the regulation
of ace expression during embryogenesis.
acknowledgement: "We thank Corinne Houart, Michael Brand and the late Nigel Holder
for comments and advice on this study, many colleagues for providing probes used
in this analysis, other members of our laboratories for suggestions throughout the
course of the work and Michael Brand, Jörg Rauch and Pascal Haffter for providing
data prior to publication. We also would like to thank Christiane Nüsslein-Volhard
in whose laboratory the mutant described in this study was initially isolated.\r\nThis
study was supported by grants from The Wellcome Trust and\r\nBBSRC. C. P. H. was
supported by Fellowships from EMBO and the\r\nEC, and S. W. W. is a Wellcome Trust
Senior Research Fellow.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Caroline
full_name: Brennan, Caroline
last_name: Brennan
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
citation:
ama: Heisenberg C-PJ, Brennan C, Wilson S. Zebrafish aussicht mutant embryos exhibit
widespread overexpression of ace (fgf8) and coincident defects in CNS development.
Development. 1999;126(10):2129-2140. doi:10.1242/dev.126.10.2129
apa: Heisenberg, C.-P. J., Brennan, C., & Wilson, S. (1999). Zebrafish aussicht
mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident
defects in CNS development. Development. Company of Biologists. https://doi.org/10.1242/dev.126.10.2129
chicago: Heisenberg, Carl-Philipp J, Caroline Brennan, and Stephen Wilson. “Zebrafish
Aussicht Mutant Embryos Exhibit Widespread Overexpression of Ace (Fgf8) and Coincident
Defects in CNS Development.” Development. Company of Biologists, 1999.
https://doi.org/10.1242/dev.126.10.2129.
ieee: C.-P. J. Heisenberg, C. Brennan, and S. Wilson, “Zebrafish aussicht mutant
embryos exhibit widespread overexpression of ace (fgf8) and coincident defects
in CNS development,” Development, vol. 126, no. 10. Company of Biologists,
pp. 2129–2140, 1999.
ista: Heisenberg C-PJ, Brennan C, Wilson S. 1999. Zebrafish aussicht mutant embryos
exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS
development. Development. 126(10), 2129–2140.
mla: Heisenberg, Carl-Philipp J., et al. “Zebrafish Aussicht Mutant Embryos Exhibit
Widespread Overexpression of Ace (Fgf8) and Coincident Defects in CNS Development.”
Development, vol. 126, no. 10, Company of Biologists, 1999, pp. 2129–40,
doi:10.1242/dev.126.10.2129.
short: C.-P.J. Heisenberg, C. Brennan, S. Wilson, Development 126 (1999) 2129–2140.
date_created: 2018-12-11T12:07:34Z
date_published: 1999-05-15T00:00:00Z
date_updated: 2022-09-06T08:38:01Z
day: '15'
doi: 10.1242/dev.126.10.2129
extern: '1'
external_id:
pmid:
- '10207138'
intvolume: ' 126'
issue: '10'
language:
- iso: eng
month: '05'
oa_version: None
page: 2129 - 2140
pmid: 1
publication: Development
publication_identifier:
issn:
- 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace
(fgf8) and coincident defects in CNS development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 126
year: '1999'
...