---
_id: '883'
abstract:
- lang: eng
text: Sympatric speciation, the origin of two or more species from a single local
population, has almost certainly been involved in formation of several species
flocks, and may be fairly common in nature. The most straightforward scenario
for sympatric speciation requires disruptive selection favouring two substantially
different phenotypes, and consists of the evolution of reproductive isolation
between them followed by the elimination of all intermediate phenotypes. Here
we use the hypergeometric phenotypic model to show that sympatric speciation is
possible even when fitness and mate choice depend on different quantitative traits,
so that speciation must involve formation of covariance between these traits.
The increase in the number of variable loci affecting fitness facilitates sympatric
speciation, whereas the increase in the number of variable loci affecting mate
choice has the opposite effect. These predictions may enable more cases of sympatric
speciation to be identified.
acknowledgement: This study was supported by a grant from the NSF.
article_processing_charge: No
article_type: original
author:
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov A, Kondrashov F. Interactions among quantitative traits in the course
of sympatric speciation. Nature. 1999;400(6742):351-354. doi:10.1038/22514
apa: Kondrashov, A., & Kondrashov, F. (1999). Interactions among quantitative
traits in the course of sympatric speciation. Nature. Nature Publishing
Group. https://doi.org/10.1038/22514
chicago: Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative
Traits in the Course of Sympatric Speciation.” Nature. Nature Publishing
Group, 1999. https://doi.org/10.1038/22514.
ieee: A. Kondrashov and F. Kondrashov, “Interactions among quantitative traits in
the course of sympatric speciation,” Nature, vol. 400, no. 6742. Nature
Publishing Group, pp. 351–354, 1999.
ista: Kondrashov A, Kondrashov F. 1999. Interactions among quantitative traits in
the course of sympatric speciation. Nature. 400(6742), 351–354.
mla: Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative
Traits in the Course of Sympatric Speciation.” Nature, vol. 400, no. 6742,
Nature Publishing Group, 1999, pp. 351–54, doi:10.1038/22514.
short: A. Kondrashov, F. Kondrashov, Nature 400 (1999) 351–354.
date_created: 2018-12-11T11:49:00Z
date_published: 1999-07-01T00:00:00Z
date_updated: 2023-04-13T10:33:44Z
day: '01'
doi: 10.1038/22514
extern: '1'
external_id:
pmid:
- '10432111'
intvolume: ' 400'
issue: '6742'
language:
- iso: eng
month: '07'
oa_version: None
page: 351 - 354
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '6761'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions among quantitative traits in the course of sympatric speciation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 400
year: '1999'
...
---
_id: '4582'
abstract:
- lang: eng
text: "We present a formal model for concurrent systems. The model represents synchronous
and asynchronous components in a uniform framework that supports compositional
(assume-guarantee) and hierarchical (stepwise-refinement) design and verification.
While synchronous models are based on a notion of atomic computation step, and
asynchronous models remove that notion by introducing stuttering, our model is
based on a flexible notion of what constitutes a computation step: by applying
an abstraction operator to a system, arbitrarily many consecutive steps can be
collapsed into a single step. The abstraction operator, which may turn an asynchronous
system into a synchronous one, allows us to describe systems at various levels
of temporal detail. For describing systems at various levels of spatial detail,
we use a hiding operator that may turn a synchronous system into an asynchronous
one. We illustrate the model with diverse examples from synchronous circuits,
asynchronous shared-memory programs, and synchronous message-passing protocols.\r\n"
acknowledgement: "We thank Albert Benveniste, Bob Kurshan, Ken McMillan, Amir Pnueli,
and the VIS group at UC Berkeley for fruitful discussions. We also thank the anonymous
referees for suggesting improvements. Alur was supported in part by the DARPA/NASA
grant NAG2-1214 and Henzinger was supported in part by the ONR YIP award N00014-95-1-0520,
the\r\nNSF CAREER award CCR-9501708, the NSF grant CCR-9504469, the DARPA/NASA grant
NAG2-1214, and by the SRC contract 97-DC-324.041."
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: Alur R, Henzinger TA. Reactive modules. Formal Methods in System Design.
1999;15(1):7-48. doi:10.1023/A:1008739929481
apa: Alur, R., & Henzinger, T. A. (1999). Reactive modules. Formal Methods
in System Design. Springer. https://doi.org/10.1023/A:1008739929481
chicago: Alur, Rajeev, and Thomas A Henzinger. “Reactive Modules.” Formal Methods
in System Design. Springer, 1999. https://doi.org/10.1023/A:1008739929481.
ieee: R. Alur and T. A. Henzinger, “Reactive modules,” Formal Methods in System
Design, vol. 15, no. 1. Springer, pp. 7–48, 1999.
ista: Alur R, Henzinger TA. 1999. Reactive modules. Formal Methods in System Design.
15(1), 7–48.
mla: Alur, Rajeev, and Thomas A. Henzinger. “Reactive Modules.” Formal Methods
in System Design, vol. 15, no. 1, Springer, 1999, pp. 7–48, doi:10.1023/A:1008739929481.
short: R. Alur, T.A. Henzinger, Formal Methods in System Design 15 (1999) 7–48.
date_created: 2018-12-11T12:09:35Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-02T08:45:58Z
day: '01'
doi: 10.1023/A:1008739929481
extern: '1'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 7 - 48
publication: Formal Methods in System Design
publication_identifier:
issn:
- 0925-9856
publication_status: published
publisher: Springer
publist_id: '125'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reactive modules
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '1999'
...
---
_id: '4601'
abstract:
- lang: eng
text: "Temporal logic comes in two varieties: linear-time temporal logic assumes
implicit universal quantification over all paths that are generated by system
moves; branching-time temporal logic allows explicit existential and universal
quantification over all paths. We introduce a third, more general variety of temporal
logic: alternating-time temporal logic offers selective quantification over those
paths that are possible outcomes of games, such as the game in which the system
and the environment alternate moves. While linear-time and branching-time logics
are natural specification languages for closed systems, alternating-time logics
are natural specification languages for open systems. For example, by preceding
the temporal operator “eventually” with a selective path quantifier, we can specify
that in the game between the system and the environment, the system has a strategy
to reach a certain state. Also the problems of receptiveness, realizability, and
controllability can be formulated as model-checking problems for alternating-time
formulas.\r\nDepending on whether we admit arbitrary nesting of selective path
quantifiers and temporal operators, we obtain the two alternating-time temporal
logics ATL and ATL. We interpret the formulas of ATL and ATL over alternating
transition systems. While in ordinary transition systems, each transition corresponds
to a possible step of the system, in alternating transition systems, each transition
corresponds to a possible move in the game between the system and the environment.
Fair alternating transition systems can capture both synchronous and asynchronous
compositions of open systems. For synchronous systems, the expressive power of
ATL beyond CTL comes at no cost: the model-checking complexity of synchronous
ATL is linear in the size of the system and the length of the formula. The symbolic
model-checking algorithm for CTL extends with few modifications to synchronous
ATL, and with some work, also to asynchronous ATL, whose model-checking complexity
is quadratic. This makes ATL an obvious candidate for the automatic verification
of open systems. In the case of ATL, the model-checking problem is closely related
to the synthesis problem for linear-time formulas, and requires doubly exponential
time for both synchronous and asynchronous systems.\r\nA preliminary version of
this paper appeared in the Proceedings of the 38th IEEE Symposium on Foundations
of Computer Science (FOCS 1997), pp. 100–109."
acknowledgement: This work was supported in part by the ONR YIP award N00014-95-1-0520,
by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR
contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA
grant NAG2-892, and by the SRC contract 97-DC-324.041.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: 'Alur R, Henzinger TA, Kupferman O. Alternating-time temporal logic. In: Proceedings
of the International Symposium on Compositionality. Vol 1536. Springer; 1999:23-60.
doi:10.1007/3-540-49213-5_2'
apa: 'Alur, R., Henzinger, T. A., & Kupferman, O. (1999). Alternating-time temporal
logic. In Proceedings of the International Symposium on Compositionality
(Vol. 1536, pp. 23–60). Bad Malente, Germany: Springer. https://doi.org/10.1007/3-540-49213-5_2'
chicago: Alur, Rajeev, Thomas A Henzinger, and Orna Kupferman. “Alternating-Time
Temporal Logic.” In Proceedings of the International Symposium on Compositionality,
1536:23–60. Springer, 1999. https://doi.org/10.1007/3-540-49213-5_2.
ieee: R. Alur, T. A. Henzinger, and O. Kupferman, “Alternating-time temporal logic,”
in Proceedings of the International Symposium on Compositionality, Bad
Malente, Germany, 1999, vol. 1536, pp. 23–60.
ista: 'Alur R, Henzinger TA, Kupferman O. 1999. Alternating-time temporal logic.
Proceedings of the International Symposium on Compositionality. COMPOS: Compositionality,
LNCS, vol. 1536, 23–60.'
mla: Alur, Rajeev, et al. “Alternating-Time Temporal Logic.” Proceedings of the
International Symposium on Compositionality, vol. 1536, Springer, 1999, pp.
23–60, doi:10.1007/3-540-49213-5_2.
short: R. Alur, T.A. Henzinger, O. Kupferman, in:, Proceedings of the International
Symposium on Compositionality, Springer, 1999, pp. 23–60.
conference:
end_date: 1997-09-12
location: Bad Malente, Germany
name: 'COMPOS: Compositionality'
start_date: 1997-09-08
date_created: 2018-12-11T12:09:41Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-01T14:23:41Z
day: '01'
doi: 10.1007/3-540-49213-5_2
extern: '1'
intvolume: ' 1536'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 60
publication: Proceedings of the International Symposium on Compositionality
publication_identifier:
isbn:
- '9783540654933'
publication_status: published
publisher: Springer
publist_id: '106'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Alternating-time temporal logic
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1536
year: '1999'
...
---
_id: '4602'
abstract:
- lang: eng
text: 'Modular techniques for automatic verification attempt to overcome the state-explosion
problem by exploiting the modular structure naturally present in many system designs.
Unlike other tasks in the verification of finite-state systems, current modular
techniques rely heavily on user guidance. In particular, the user is typically
required to construct module abstractions that are neither too detailed as to
render insufficient benefits in state exploration, nor too coarse as to invalidate
the desired systemproperties. In this paper, we construct abstractmodules automatically,
using reachability and controllability information about the concrete modules.
This allows us to leverage automatic verification techniques by applying them
in layers: first we compute on the state spaces of system components, then we
use the results for constructing abstractions, and finally we compute on the abstract
state space of the system. Our experimental results indicate that if reachability
and controllability information is used in the construction of abstractions, the
resulting abstract modules are often significantly smaller than the concrete modules
and can drastically reduce the space and time requirements for verification.'
acknowledgement: This research was supported in part by the NSF CAREER award CCR-9734115,
by the NSF CAREER award CCR-9501708, by the DARPA (NASA Ames) grant NAG2-1214, by
the DARPA (Wright-Patterson AFB) grant F33615-98-C-3614, by the ARO MURI grant DAAH-
04-96-1-0341, and by the Gigascale Silicon Research Center.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
full_name: Alur, Rajeev
last_name: Alur
- first_name: Luca
full_name: De Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Freddy
full_name: Mang, Freddy
last_name: Mang
citation:
ama: 'Alur R, De Alfaro L, Henzinger TA, Mang F. Automating modular verification.
In: Proceedings of the 10th International Conference on Concurrency Theory.
Vol 1664. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1999:82-97. doi:10.1007/3-540-48320-9_8'
apa: 'Alur, R., De Alfaro, L., Henzinger, T. A., & Mang, F. (1999). Automating
modular verification. In Proceedings of the 10th International Conference on
Concurrency Theory (Vol. 1664, pp. 82–97). Eindhoven, The Netherlands: Schloss
Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-48320-9_8'
chicago: Alur, Rajeev, Luca De Alfaro, Thomas A Henzinger, and Freddy Mang. “Automating
Modular Verification.” In Proceedings of the 10th International Conference
on Concurrency Theory, 1664:82–97. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik, 1999. https://doi.org/10.1007/3-540-48320-9_8.
ieee: R. Alur, L. De Alfaro, T. A. Henzinger, and F. Mang, “Automating modular verification,”
in Proceedings of the 10th International Conference on Concurrency Theory,
Eindhoven, The Netherlands, 1999, vol. 1664, pp. 82–97.
ista: 'Alur R, De Alfaro L, Henzinger TA, Mang F. 1999. Automating modular verification.
Proceedings of the 10th International Conference on Concurrency Theory. CONCUR:
Concurrency Theory, LNCS, vol. 1664, 82–97.'
mla: Alur, Rajeev, et al. “Automating Modular Verification.” Proceedings of the
10th International Conference on Concurrency Theory, vol. 1664, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 1999, pp. 82–97, doi:10.1007/3-540-48320-9_8.
short: R. Alur, L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 10th
International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 1999, pp. 82–97.
conference:
end_date: 1999-08-27
location: Eindhoven, The Netherlands
name: 'CONCUR: Concurrency Theory'
start_date: 1999-08-24
date_created: 2018-12-11T12:09:42Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-01T14:15:35Z
day: '01'
doi: 10.1007/3-540-48320-9_8
extern: '1'
intvolume: ' 1664'
language:
- iso: eng
month: '01'
oa_version: None
page: 82 - 97
publication: Proceedings of the 10th International Conference on Concurrency Theory
publication_identifier:
isbn:
- '9783540664253'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '105'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automating modular verification
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1664
year: '1999'
...
---
_id: '11895'
abstract:
- lang: eng
text: In this paper we present an analysis of an AltaVista Search Engine query log
consisting of approximately 1 billion entries for search requests over a period
of six weeks. This represents almost 285 million user sessions, each an attempt
to fill a single information need. We present an analysis of individual queries,
query duplication, and query sessions. We also present results of a correlation
analysis of the log entries, studying the interaction of terms within queries.
Our data supports the conjecture that web users differ significantly from the
user assumed in the standard information retrieval literature. Specifically, we
show that web users type in short queries, mostly look at the first 10 results
only, and seldom modify the query. This suggests that traditional information
retrieval techniques may not work well for answering web search requests. The
correlation analysis showed that the most highly correlated items are constituents
of phrases. This result indicates it may be useful for search engines to consider
search terms as parts of phrases even if the user did not explicitly specify them
as such.
article_processing_charge: No
article_type: original
author:
- first_name: Craig
full_name: Silverstein, Craig
last_name: Silverstein
- first_name: Hannes
full_name: Marais, Hannes
last_name: Marais
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Michael
full_name: Moricz, Michael
last_name: Moricz
citation:
ama: Silverstein C, Marais H, Henzinger MH, Moricz M. Analysis of a very large web
search engine query log. ACM SIGIR Forum. 1999;33(1):6-12. doi:10.1145/331403.331405
apa: Silverstein, C., Marais, H., Henzinger, M. H., & Moricz, M. (1999). Analysis
of a very large web search engine query log. ACM SIGIR Forum. Association
for Computing Machinery. https://doi.org/10.1145/331403.331405
chicago: Silverstein, Craig, Hannes Marais, Monika H Henzinger, and Michael Moricz.
“Analysis of a Very Large Web Search Engine Query Log.” ACM SIGIR Forum.
Association for Computing Machinery, 1999. https://doi.org/10.1145/331403.331405.
ieee: C. Silverstein, H. Marais, M. H. Henzinger, and M. Moricz, “Analysis of a
very large web search engine query log,” ACM SIGIR Forum, vol. 33, no.
1. Association for Computing Machinery, pp. 6–12, 1999.
ista: Silverstein C, Marais H, Henzinger MH, Moricz M. 1999. Analysis of a very
large web search engine query log. ACM SIGIR Forum. 33(1), 6–12.
mla: Silverstein, Craig, et al. “Analysis of a Very Large Web Search Engine Query
Log.” ACM SIGIR Forum, vol. 33, no. 1, Association for Computing Machinery,
1999, pp. 6–12, doi:10.1145/331403.331405.
short: C. Silverstein, H. Marais, M.H. Henzinger, M. Moricz, ACM SIGIR Forum 33
(1999) 6–12.
date_created: 2022-08-17T08:53:02Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-02-17T14:46:04Z
day: '01'
doi: 10.1145/331403.331405
extern: '1'
intvolume: ' 33'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/331403.331405
month: '01'
oa: 1
oa_version: Published Version
page: 6-12
publication: ACM SIGIR Forum
publication_identifier:
issn:
- 0163-5840
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of a very large web search engine query log
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '1999'
...
---
_id: '11925'
abstract:
- lang: eng
text: "This paper studies the multicast routing and admission control problem on
unit-capacity tree and mesh topologies in the throughput-model. The problem is
a generalization of the edge-disjoint paths problem and is NPhard both on trees
and meshes. We study both the offline and the online version of the problem: In
the offline setting, we give the first\r\nconstant-factor approximation algorithm
for trees, and an O((log log n)*)-factor approximation algorithm for meshes, where
n is the number of nodes in the graph. In the online setting, we give the first
polylogarithrnic competitive online algorithm for tree and mesh topologies. No
polylogarithmic-competitive algorithm is possible on general network topologies
[8] and there\r\nexists a polylogarithmic lower bound on the competitive ratio
of any online algorithm on tree topologies [l]. We prove the same lower bound
for meshes. "
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Stefano
full_name: Leonardi , Stefano
last_name: 'Leonardi '
citation:
ama: 'Henzinger MH, Leonardi S. Scheduling multicasts on unit-capacity trees
and meshes. In: 10th Annual ACM-SIAM Symposium on Discrete Algorithms.
Society for Industrial & Applied Mathematics; 1999:438-447.'
apa: 'Henzinger, M. H., & Leonardi , S. (1999). Scheduling multicasts on unit-capacity
trees and meshes. In 10th Annual ACM-SIAM Symposium on Discrete Algorithms
(pp. 438–447). Baltimore, MD, United States: Society for Industrial & Applied
Mathematics.'
chicago: Henzinger, Monika H, and Stefano Leonardi . “Scheduling Multicasts on
Unit-Capacity Trees and Meshes.” In 10th Annual ACM-SIAM Symposium on Discrete
Algorithms, 438–47. Society for Industrial & Applied Mathematics, 1999.
ieee: M. H. Henzinger and S. Leonardi , “Scheduling multicasts on unit-capacity
trees and meshes,” in 10th Annual ACM-SIAM Symposium on Discrete Algorithms,
Baltimore, MD, United States, 1999, pp. 438–447.
ista: 'Henzinger MH, Leonardi S. 1999. Scheduling multicasts on unit-capacity
trees and meshes. 10th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA:
Symposium on Discrete Algorithms, 438–447.'
mla: Henzinger, Monika H., and Stefano Leonardi . “Scheduling Multicasts on Unit-Capacity
Trees and Meshes.” 10th Annual ACM-SIAM Symposium on Discrete Algorithms,
Society for Industrial & Applied Mathematics, 1999, pp. 438–47.
short: M.H. Henzinger, S. Leonardi , in:, 10th Annual ACM-SIAM Symposium on Discrete
Algorithms, Society for Industrial & Applied Mathematics, 1999, pp. 438–447.
conference:
end_date: 1999-01-19
location: Baltimore, MD, United States
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 1999-01-17
date_created: 2022-08-18T12:45:50Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-02-17T12:08:26Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 438-447
publication: 10th Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '0898714346'
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scheduling multicasts on unit-capacity trees and meshes
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3456'
abstract:
- lang: eng
text: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and
N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic
glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the
mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric
proteins, probably tetramers, formed by a variety of molecularly distinct subunits.
AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and
-D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional
molecular diversity of AMPARs is generated by alternative splicing of the flip-flop
module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily
assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants
have been identified for the NR1 subunit, and a new NR3 subunit has been discovered
recently. Considering all combinatorial possibilities, the molecular diversity
of glutamate-receptor channels is considerable (HOLLMANN, this volume).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Jean
full_name: Rossier, Jean
last_name: Rossier
citation:
ama: 'Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H,
eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339.
doi:10.1007/978-3-662-08022-1_9'
apa: Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants
controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In
P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS
(Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9
chicago: Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants
Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.”
In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and
Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9.
ieee: H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling
functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic
Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds.
Springer, 1999, pp. 309–339.
ista: 'Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate
Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.'
mla: Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties
of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors
in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer,
1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9.
short: H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic
Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339.
date_created: 2018-12-11T12:03:25Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:30:23Z
day: '01'
doi: 10.1007/978-3-662-08022-1_9
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 309 - 339
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular determinants controlling functional properties of AMPARs and NMDARs
in the mammalian CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3457'
abstract:
- lang: eng
text: Principal neurons and interneurons are the two main classes of cells in cortical
neuronal networks. Principal neurons (granule cells or pyramidal neurons) have
transregional axonal projections and release glutamate onto their postsynaptic
target cells. In contrast, interneurons have local, but often extensive, axonal
arborizations and use γ-aminobutyric acid (GABA) as a transmitter. Although interneurons
represent only approximately 10% of the neuronal population, they control the
electrical activity of the entire network (FREUND and BUZSÁKI 1996). Interneurons
forming inhibitory synapses on the somata or axon initial segments of their postsynaptic
target cells are thought to set the threshold of action potential initiation (MILES
et al. 1996) and can synchronize the collective activities of large principal
neuron ensembles (COBB et al. 1995). In contrast, interneurons establishing inhibitory
synapses mainly on dendrites could suppress dendritic Na+ or Ca2+ spikes (BUZSÁKI
et al. 1996; MILES et al. 1996) and, thus, regulate plasticity at glutamatergic
synapses in the cortex (DAVIES et al.1991).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Arnd
full_name: Roth, Arnd
last_name: Roth
- first_name: Birol
full_name: Taskin, Birol
last_name: Taskin
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Geiger J, Roth A, Taskin B, Jonas PM. Glutamate-mediated synaptic excitation
of cortical interneurons. In: Monyer H, Jonas PM, eds. Ionotropic Glutamate
Receptors in the CNS. Vol 141. Springer; 1999:363-398. doi:10.1007/978-3-662-08022-1_11'
apa: Geiger, J., Roth, A., Taskin, B., & Jonas, P. M. (1999). Glutamate-mediated
synaptic excitation of cortical interneurons. In H. Monyer & P. M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 363–398). Springer.
https://doi.org/10.1007/978-3-662-08022-1_11
chicago: Geiger, Jörg, Arnd Roth, Birol Taskin, and Peter M Jonas. “Glutamate-Mediated
Synaptic Excitation of Cortical Interneurons.” In Ionotropic Glutamate Receptors
in the CNS, edited by Hannah Monyer and Peter M Jonas, 141:363–98. Springer,
1999. https://doi.org/10.1007/978-3-662-08022-1_11.
ieee: J. Geiger, A. Roth, B. Taskin, and P. M. Jonas, “Glutamate-mediated synaptic
excitation of cortical interneurons,” in Ionotropic Glutamate Receptors in
the CNS, vol. 141, H. Monyer and P. M. Jonas, Eds. Springer, 1999, pp. 363–398.
ista: 'Geiger J, Roth A, Taskin B, Jonas PM. 1999.Glutamate-mediated synaptic excitation
of cortical interneurons. In: Ionotropic Glutamate Receptors in the CNS. Handbook
of experimental pharmacology, vol. 141, 363–398.'
mla: Geiger, Jörg, et al. “Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.”
Ionotropic Glutamate Receptors in the CNS, edited by Hannah Monyer and
Peter M Jonas, vol. 141, Springer, 1999, pp. 363–98, doi:10.1007/978-3-662-08022-1_11.
short: J. Geiger, A. Roth, B. Taskin, P.M. Jonas, in:, H. Monyer, P.M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 363–398.
date_created: 2018-12-11T12:03:26Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:25:46Z
day: '01'
doi: 10.1007/978-3-662-08022-1_11
editor:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 363 - 398
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2930'
quality_controlled: '1'
status: public
title: Glutamate-mediated synaptic excitation of cortical interneurons
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3515'
abstract:
- lang: eng
text: Oscillations in neuronal networks are assumed to serve various physiological
functions, from coordination of motor patterns to perceptual binding of sensory
information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus.
Extracellular and intracellular activity was recorded from the CA1 and subicular
regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane.
in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s)
occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast
increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed
by large-amplitude rhythmic waves and associated action potentials at gamma and
beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally
synchronous and terminated relatively abruptly without post-ictal depression.
Single-pulse stimulation of the commissural input could trigger afterdischarges,
but only at times when they were about to occur. Commissural stimulation evoked
inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus
triggered an afterdischarge, the inhibitory postsynaptic potential was absent
and the cells remained depolarized during most of the afterdischarge. Afterdischarges
were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal
activity in intact, drug-free rats also revealed periodic excitability changes
in the hippocampal network at 0.025 Hz. These findings indicate the presence of
an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced
afterdischarges in susceptible animals. We hypothesize that a transient failure
of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence
of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.
acknowledgement: This work was supported by the Academy of Finland (32391) and the
NIH (NS34994, MH54671).
article_processing_charge: No
article_type: original
author:
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Nina
full_name: Nurminen, Nina
last_name: Nurminen
- first_name: Riitta
full_name: Miettinen, Riitta
last_name: Miettinen
- first_name: Jouni
full_name: Sirviö, Jouni
last_name: Sirviö
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025
Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience.
1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X
apa: Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari,
J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X
chicago: Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell
Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025
Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience.
Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X.
ieee: M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier,
pp. 735–743, 1999.
ista: Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki
G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges
in Wistar rats. Neuroscience. 94(3), 735–743.
mla: Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal
Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier,
1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X.
short: M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari,
G. Buzsáki, Neuroscience 94 (1999) 735–743.
date_created: 2018-12-11T12:03:44Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-07T13:16:01Z
day: '01'
doi: 10.1016/S0306-4522(99)00367-X
extern: '1'
external_id:
pmid:
- '10579564'
intvolume: ' 94'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 735 - 743
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2870'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar
rats
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3519'
abstract:
- lang: eng
text: 'In contrast to sensory cortical areas of the brain, the relevant physiological
inputs to the hippocampus, leading to selective activation of pyramidal cells,
are largely unknown. Pyramidal cells are thought to be phasically activated by
spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural
`space clamp'' method, which involved the confinement of the actively running
animal in a defined position in space (running wheel) and kept sensory inputs
constant. Twelve percent of the recorded CA1 pyramidal cells were selectively
active while the rat was running in the wheel. Cell firing was specific to the
direction of running and disappeared after rotating the recording apparatus. The
discharge frequency of pyramidal cells and interneurons was sustained as long
as the rat ran continuously in the wheel. Furthermore, the discharge frequency
of pyramidal cells and interneurons increased with increasing running velocity,
even though the frequency of hippocampal theta waves remained constant. The discharge
frequency of some `wheel-related'' pyramidal cells could increase more than 10-fold
between 10 and 100 cm/s, whereas the firing rate of `non-wheel'' cells remained
constantly low. We hypothesize that: (i) a necessary condition for place-specific
discharge of hippocampal pyramidal cells is the presence of theta oscillation;
and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal
cells as long as theta activity is present.'
acknowledgement: We thank M. Recce for continuous support, A. Berthoz for advice,
K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand
C. King for his comments on the manuscript. This work was supportedby NIH (NS34994,
MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State
Fellowship (A.C.) and the Soros Foundation (A.C.)
article_processing_charge: No
article_type: original
author:
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal
pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal
of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x
apa: Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained
activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x
chicago: Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki.
“Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a
Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999.
https://doi.org/10.1046/j.1460-9568.1999.00446.x.
ieee: A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation
of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European
Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999.
ista: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of
hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European
Journal of Neuroscience. 11(1), 344–352.
mla: Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells
by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience,
vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x.
short: A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 344–352.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:09:08Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00446.x
extern: '1'
external_id:
pmid:
- '9987037'
intvolume: ' 11'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 344 - 352
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2867'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sustained activation of hippocampal pyramidal cells by ‘space clamping' in
a running wheel
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3539'
abstract:
- lang: eng
text: In the hippocampus, spatial representation of the environment has been suggested
to be coded by either the firing rate of pyramidal cell assemblies or the relative
timing of the action potentials during the theta EEG cycle. Here, we used a behavioural
`space clamp' method, which involved the confinement of the actively running animal
in a defined position in space (running wheel) to examine how `spatial' and other
inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons.
Nineteen per cent of the recorded CA1 pyramidal cells were selectively active
while the rat was running in the wheel in a given direction ('wheel' cells). Spatial
rotation of the apparatus showed that selective discharge of pyramidal cells in
the wheel was under the combined influence of distal and apparatus cues. During
steady running, both discharge rate and theta phase were constant. Rotation of
the wheel apparatus resulted in a shift of both firing rate and preferred theta
phase. The discharge frequency of `wheel' cells increased threefold (on average)
with increasing running velocity. In contrast, change in running speed had relatively
little effect on the theta phase-related discharge of `wheel' cells. Our findings
indicate that mechanisms that regulate rate and phase of spikes are overlapping
but not necessarily identical.
acknowledgement: 'We thank M. Recce for his comments on the manuscript. This work
wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.),
the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) '
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding
by hippocampal pyramidal neurons during ‘space clamping.’ European Journal
of Neuroscience. 1999;11(12):4373-4380. doi:10.1046/j.1460-9568.1999.00853.x
apa: Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Firing
rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00853.x
chicago: Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki.
“Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space
Clamping.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00853.x.
ieee: H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping,’” European
Journal of Neuroscience, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380,
1999.
ista: Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase
coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal
of Neuroscience. 11(12), 4373–4380.
mla: Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal
Neurons during ‘Space Clamping.’” European Journal of Neuroscience, vol.
11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:10.1046/j.1460-9568.1999.00853.x.
short: H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 4373–4380.
date_created: 2018-12-11T12:03:51Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:45:36Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00853.x
extern: '1'
external_id:
pmid:
- '10594664 '
intvolume: ' 11'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 4373 - 4380
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2845'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Firing rate and theta-phase coding by hippocampal pyramidal neurons during
‘space clamping’
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '3554'
abstract:
- lang: eng
text: In computational simulation of coupled, multicomponent systems, it is frequently
necessary to transfer data between meshes that may differ in resolution, structure,
and discretization methodology. Typically, nodes from one mesh must be associated
with elements of another mesh. In this paper, we formulate mesh association as
a geometric problem and introduce two efficient mesh association algorithms. One
of these algorithms requires linear time in the worst case if the meshes are well
shaped and geometrically well aligned. Our formulation of the problem and our
algorithms are more general than previous work and can be applied to surface meshes
with curved elements.
article_processing_charge: No
author:
- first_name: Xiangmin
full_name: Jiao, Xiangmin
last_name: Jiao
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Heath, Michael
last_name: Heath
citation:
ama: 'Jiao X, Edelsbrunner H, Heath M. Mesh association: formulation and algorithms.
In: Proceedings of the 8th International Meshing Roundtable. Elsevier;
1999:75-82.'
apa: 'Jiao, X., Edelsbrunner, H., & Heath, M. (1999). Mesh association: formulation
and algorithms. In Proceedings of the 8th International Meshing Roundtable
(pp. 75–82). South Lake Tahoe, CA, United States of America: Elsevier.'
chicago: 'Jiao, Xiangmin, Herbert Edelsbrunner, and Michael Heath. “Mesh Association:
Formulation and Algorithms.” In Proceedings of the 8th International Meshing
Roundtable, 75–82. Elsevier, 1999.'
ieee: 'X. Jiao, H. Edelsbrunner, and M. Heath, “Mesh association: formulation and
algorithms,” in Proceedings of the 8th International Meshing Roundtable,
South Lake Tahoe, CA, United States of America, 1999, pp. 75–82.'
ista: 'Jiao X, Edelsbrunner H, Heath M. 1999. Mesh association: formulation and
algorithms. Proceedings of the 8th International Meshing Roundtable. IMR: International
Meshing Roundtable, 75–82.'
mla: 'Jiao, Xiangmin, et al. “Mesh Association: Formulation and Algorithms.” Proceedings
of the 8th International Meshing Roundtable, Elsevier, 1999, pp. 75–82.'
short: X. Jiao, H. Edelsbrunner, M. Heath, in:, Proceedings of the 8th International
Meshing Roundtable, Elsevier, 1999, pp. 75–82.
conference:
end_date: 1999-10-13
location: South Lake Tahoe, CA, United States of America
name: 'IMR: International Meshing Roundtable'
start_date: 1999-10-10
date_created: 2018-12-11T12:03:56Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-06T09:35:53Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.35.2959
month: '10'
oa_version: None
page: 75 - 82
publication: Proceedings of the 8th International Meshing Roundtable
publication_status: published
publisher: Elsevier
publist_id: '2831'
quality_controlled: '1'
status: public
title: 'Mesh association: formulation and algorithms'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1999'
...
---
_id: '3571'
alternative_title:
- Contemporary Mathematics
article_processing_charge: No
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sumanta
full_name: Guha, Sumanta
last_name: Guha
citation:
ama: 'Dey T, Edelsbrunner H, Guha S. Computational topology. In: Advances in
Discrete and Computational Geometry. Vol 223. American Mathematical Society;
1999:109-143.'
apa: Dey, T., Edelsbrunner, H., & Guha, S. (1999). Computational topology. In
Advances in Discrete and Computational Geometry (Vol. 223, pp. 109–143).
American Mathematical Society.
chicago: Dey, Tamal, Herbert Edelsbrunner, and Sumanta Guha. “Computational Topology.”
In Advances in Discrete and Computational Geometry, 223:109–43. American
Mathematical Society, 1999.
ieee: T. Dey, H. Edelsbrunner, and S. Guha, “Computational topology,” in Advances
in Discrete and Computational Geometry, vol. 223, American Mathematical Society,
1999, pp. 109–143.
ista: 'Dey T, Edelsbrunner H, Guha S. 1999.Computational topology. In: Advances
in Discrete and Computational Geometry. Contemporary Mathematics, vol. 223, 109–143.'
mla: Dey, Tamal, et al. “Computational Topology.” Advances in Discrete and Computational
Geometry, vol. 223, American Mathematical Society, 1999, pp. 109–43.
short: T. Dey, H. Edelsbrunner, S. Guha, in:, Advances in Discrete and Computational
Geometry, American Mathematical Society, 1999, pp. 109–143.
date_created: 2018-12-11T12:04:01Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-06T09:28:57Z
day: '01'
extern: '1'
intvolume: ' 223'
language:
- iso: eng
month: '01'
oa_version: None
page: 109 - 143
publication: Advances in Discrete and Computational Geometry
publication_identifier:
isbn:
- '9780821878149'
publication_status: published
publisher: American Mathematical Society
publist_id: '2814'
quality_controlled: '1'
status: public
title: Computational topology
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 223
year: '1999'
...
---
_id: '3582'
abstract:
- lang: eng
text: We study edge contractions in simplicial complexes and local conditions under
which they preserve the topological type. The conditions are based on a generalized
notion of boundary, which lends itself to defining a nested hierarchy of triangulable
spaces measuring the distance to being a manifold.
acknowledgement: The second author thanks Wolfgang Haken and Min Yan for interesting
discussions and Günter Ziegler for suggesting the knot construction in the triangulation
of the 3-sphere mentioned in Section 7.
article_processing_charge: No
article_type: original
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sumanta
full_name: Guha, Sumanta
last_name: Guha
- first_name: Dmitry
full_name: Nekhayev, Dmitry
last_name: Nekhayev
citation:
ama: Dey T, Edelsbrunner H, Guha S, Nekhayev D. Topology preserving edge contraction.
Publications de l’Institut Mathématique. 1999;66:23-45.
apa: Dey, T., Edelsbrunner, H., Guha, S., & Nekhayev, D. (1999). Topology preserving
edge contraction. Publications de l’Institut Mathématique. Mathematical
Institute, Serbian Academy of Sciences and Arts.
chicago: Dey, Tamal, Herbert Edelsbrunner, Sumanta Guha, and Dmitry Nekhayev. “Topology
Preserving Edge Contraction.” Publications de l’Institut Mathématique.
Mathematical Institute, Serbian Academy of Sciences and Arts, 1999.
ieee: T. Dey, H. Edelsbrunner, S. Guha, and D. Nekhayev, “Topology preserving edge
contraction,” Publications de l’Institut Mathématique, vol. 66. Mathematical
Institute, Serbian Academy of Sciences and Arts, pp. 23–45, 1999.
ista: Dey T, Edelsbrunner H, Guha S, Nekhayev D. 1999. Topology preserving edge
contraction. Publications de l’Institut Mathématique. 66, 23–45.
mla: Dey, Tamal, et al. “Topology Preserving Edge Contraction.” Publications
de l’Institut Mathématique, vol. 66, Mathematical Institute, Serbian Academy
of Sciences and Arts, 1999, pp. 23–45.
short: T. Dey, H. Edelsbrunner, S. Guha, D. Nekhayev, Publications de l’Institut
Mathématique 66 (1999) 23–45.
date_created: 2018-12-11T12:04:05Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-03-22T13:20:32Z
day: '01'
extern: '1'
intvolume: ' 66'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.emis.de/journals/PIMB/080/3.html
month: '01'
oa: 1
oa_version: None
page: 23 - 45
publication: Publications de l'Institut Mathématique
publication_identifier:
issn:
- 0350-1302
publication_status: published
publisher: Mathematical Institute, Serbian Academy of Sciences and Arts
publist_id: '2803'
quality_controlled: '1'
status: public
title: Topology preserving edge contraction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1999'
...
---
_id: '3625'
abstract:
- lang: eng
text: 'This article outlines theoretical models of clines in additive polygenic
traits, which are maintained by stabilizing selection towards a spatially varying
optimum. Clines in the trait mean can be accurately predicted, given knowledge
of the genetic variance. However, predicting the variance is difficult, because
it depends on genetic details. Changes in genetic variance arise from changes
in allele frequency, and in linkage disequilibria. Allele frequency changes dominate
when selection is weak relative to recombination, and when there are a moderate
number of loci. With a continuum of alleles, gene flow inflates the genetic variance
in the same way as a source of mutations of small effect. The variance can be
approximated by assuming a Gaussian distribution of allelic effects; with a sufficiently
steep cline, this is accurate even when mutation and selection alone are better
described by the ''House of Cards'' approximation. With just two alleles at each
locus, the phenotype changes in a similar way: the mean remains close to the optimum,
while the variance changes more slowly, and over a wider region. However, there
may be substantial cryptic divergence at the underlying loci. With strong selection
and many loci, linkage disequilibria are the main cause of changes in genetic
variance. Even for strong selection, the infinitesimal model can be closely approximated
by assuming a Gaussian distribution of breeding values. Linkage disequilibria
can generate a substantial increase in genetic variance, which is concentrated
at sharp gradients in trait means.'
acknowledgement: This work was supported by the Darwin Trust of Edinburgh, and by
grants MMI09726 from the BBSRC}EPSRC and GR3}11635 from the NERC. I would like to
thank R. Lande and M. Slatkin for their comments on an earlier incarnation of this
article, and Mark Kirkpatrick, Loeske Kruuk and Michael Turelli for their comments
on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Clines in polygenic traits. Genetical Research. 1999;74(3):223-236.
doi:10.1017/S001667239900422X
apa: Barton, N. H. (1999). Clines in polygenic traits. Genetical Research.
Cambridge University Press. https://doi.org/10.1017/S001667239900422X
chicago: Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research.
Cambridge University Press, 1999. https://doi.org/10.1017/S001667239900422X.
ieee: N. H. Barton, “Clines in polygenic traits,” Genetical Research, vol.
74, no. 3. Cambridge University Press, pp. 223–236, 1999.
ista: Barton NH. 1999. Clines in polygenic traits. Genetical Research. 74(3), 223–236.
mla: Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research,
vol. 74, no. 3, Cambridge University Press, 1999, pp. 223–36, doi:10.1017/S001667239900422X.
short: N.H. Barton, Genetical Research 74 (1999) 223–236.
date_created: 2018-12-11T12:04:18Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:10:35Z
day: '01'
doi: 10.1017/S001667239900422X
extern: '1'
external_id:
pmid:
- '10689800 '
intvolume: ' 74'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 223 - 236
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2758'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clines in polygenic traits
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 74
year: '1999'
...
---
_id: '3626'
abstract:
- lang: eng
text: There has recently been considerable debate over the relative importance of
selection against hybrids ("endogenous" selection) vs. adaptation to
different environments ("exogenous") in maintaining stable hybrid zones
and hence in speciation. Single-locus models of endogenous and exogenous viability
selection generate clines of similar shape, but the comparison has not been extended
to multilocus systems, which are both quantitatively and qualitatively very different
from the single-locus case. Here we develop an analytical multilocus model of
differential adaptation across an environmental transition and compare it to previous
heterozygote disadvantage models. We show that the shape of clines generated by
exogenous selection is indistinguishable from that generated by endogenous selection.
A stochastic simulation model is used to test the robustness of the analytical
description to the effects of drift and strong selection, and confirms the prediction
that pairwise linkage disequilibria are predominantly generated by migration.
However, although analytical predictions for the width of clines maintained by
heterozygote disadvantage fit well with the simulation results, those for environmental
adaptation are consistently too narrow; reasons for the discrepancy are discussed.
There is a smooth transition between a system in which a set of loci effectively
act independently of each other and one in which they act as a single nonrecombining
unit.
article_processing_charge: No
article_type: original
author:
- first_name: Loeske
full_name: Kruuk, Loeske
last_name: Kruuk
- first_name: Stuart
full_name: Baird, Stuart
last_name: Baird
- first_name: Katherine
full_name: Gale, Katherine
last_name: Gale
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kruuk L, Baird S, Gale K, Barton NH. A comparison of multilocus clines maintained
by environmental adaptation or by selection against hybrids. Genetics.
1999;153(4):1959-1971. doi:10.1093/genetics/153.4.1959
apa: Kruuk, L., Baird, S., Gale, K., & Barton, N. H. (1999). A comparison of
multilocus clines maintained by environmental adaptation or by selection against
hybrids. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/153.4.1959
chicago: Kruuk, Loeske, Stuart Baird, Katherine Gale, and Nicholas H Barton. “A
Comparison of Multilocus Clines Maintained by Environmental Adaptation or by Selection
against Hybrids.” Genetics. Genetics Society of America, 1999. https://doi.org/10.1093/genetics/153.4.1959.
ieee: L. Kruuk, S. Baird, K. Gale, and N. H. Barton, “A comparison of multilocus
clines maintained by environmental adaptation or by selection against hybrids,”
Genetics, vol. 153, no. 4. Genetics Society of America, pp. 1959–1971,
1999.
ista: Kruuk L, Baird S, Gale K, Barton NH. 1999. A comparison of multilocus clines
maintained by environmental adaptation or by selection against hybrids. Genetics.
153(4), 1959–1971.
mla: Kruuk, Loeske, et al. “A Comparison of Multilocus Clines Maintained by Environmental
Adaptation or by Selection against Hybrids.” Genetics, vol. 153, no. 4,
Genetics Society of America, 1999, pp. 1959–71, doi:10.1093/genetics/153.4.1959.
short: L. Kruuk, S. Baird, K. Gale, N.H. Barton, Genetics 153 (1999) 1959–1971.
date_created: 2018-12-11T12:04:19Z
date_published: 1999-12-01T00:00:00Z
date_updated: 2022-09-06T09:06:02Z
day: '01'
doi: 10.1093/genetics/153.4.1959
extern: '1'
external_id:
pmid:
- '10581299'
intvolume: ' 153'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 1959 - 1971
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2757'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of multilocus clines maintained by environmental adaptation or
by selection against hybrids
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 153
year: '1999'
...