---
_id: '2591'
abstract:
- lang: eng
text: The occurrence and distribution of the preferred receptor for the neuropeptide,
substance P (SP), the neurokinin-1 receptor (NK1R) was investigated in the vascular
supply of the rat sciatic nerve. Messenger RNA for NK1R was demonstrated by RT-PCR
in the epineurial layer where the majority of small arteries and arterioles feeding
the endoneurial vasculature are located. Immunoreactivity to NK1R-protein was
localized on the smooth muscle cells of these arterial vessels by means of immunofluorescence
using a polyclonal NK1R antiserum. This muscular localization of NK1R explains
the previously reported [Zochodne, D.W. and Ho, L.T., J. Physiol. 444 (1991) 615-
630] moderate vasoconstrictor rather than vasodilator effects of SP in this vascular
bed.
acknowledgement: The skillful technical assistance of Ms. T. Fischbach and Ms. K.
Michael and the secretarial help of Ms. P. Berger are gratefully appreciated.
article_processing_charge: No
article_type: original
author:
- first_name: Wolfgang
full_name: Kummer, Wolfgang
last_name: Kummer
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rainer
full_name: Haberberger, Rainer
last_name: Haberberger
citation:
ama: Kummer W, Shigemoto R, Haberberger R. Smooth muscle cells are the site of neurokinin-1
receptor localization in the arterial supply of the rat sciatic nerve. Neuroscience
Letters. 1999;259(2):119-122. doi:10.1016/S0304-3940(98)00926-4
apa: Kummer, W., Shigemoto, R., & Haberberger, R. (1999). Smooth muscle cells
are the site of neurokinin-1 receptor localization in the arterial supply of the
rat sciatic nerve. Neuroscience Letters. Elsevier. https://doi.org/10.1016/S0304-3940(98)00926-4
chicago: Kummer, Wolfgang, Ryuichi Shigemoto, and Rainer Haberberger. “Smooth Muscle
Cells Are the Site of Neurokinin-1 Receptor Localization in the Arterial Supply
of the Rat Sciatic Nerve.” Neuroscience Letters. Elsevier, 1999. https://doi.org/10.1016/S0304-3940(98)00926-4.
ieee: W. Kummer, R. Shigemoto, and R. Haberberger, “Smooth muscle cells are the
site of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve,” Neuroscience Letters, vol. 259, no. 2. Elsevier, pp. 119–122, 1999.
ista: Kummer W, Shigemoto R, Haberberger R. 1999. Smooth muscle cells are the site
of neurokinin-1 receptor localization in the arterial supply of the rat sciatic
nerve. Neuroscience Letters. 259(2), 119–122.
mla: Kummer, Wolfgang, et al. “Smooth Muscle Cells Are the Site of Neurokinin-1
Receptor Localization in the Arterial Supply of the Rat Sciatic Nerve.” Neuroscience
Letters, vol. 259, no. 2, Elsevier, 1999, pp. 119–22, doi:10.1016/S0304-3940(98)00926-4.
short: W. Kummer, R. Shigemoto, R. Haberberger, Neuroscience Letters 259 (1999)
119–122.
date_created: 2018-12-11T11:58:33Z
date_published: 1999-01-08T00:00:00Z
date_updated: 2023-03-27T10:11:02Z
day: '08'
doi: 10.1016/S0304-3940(98)00926-4
extern: '1'
external_id:
pmid:
- '10025572'
intvolume: ' 259'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 119 - 122
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4307'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Smooth muscle cells are the site of neurokinin-1 receptor localization in the
arterial supply of the rat sciatic nerve
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 259
year: '1999'
...
---
_id: '2592'
abstract:
- lang: eng
text: Metabotropic glutamate receptors (mGluRs) consist of eight different subtypes
and exert their effects or second messengers and ion channels via G- proteins.
The function of individual mGluR subtypes in the CNS, however, largely remains
to be clarified. We examined the fear response of freezing after electric shock
in wild-type and mGluR7(-/-) knockout littermates. Wild- type mice displayed freezing
immediately after and 1 d after footshock. In comparison, mGluR7(-/-) knockout
mice showed significantly reduced levels in both immediate postshock and delayed
freezing responses. However, the knockout mice exhibited no abnormalities in pain
sensitivity and locomotor activity. To further examine amygdala-dependent behavior,
we performed conditioned taste aversion (CTA) experiments. In wild-type mice,
the administration of saccharin followed by intraperitoneal injection of the malaise-inducing
agent LiCl resulted in an association between saccharin and LiCl. This association
caused strong CTA toward saccharin n contrast, mGluR7(-/-) knockout mice failed
to associate between the taste and the negative reinforcer in CTA experiments.
Again, the knockout mice showed no abnormalities in taste preference and in the
sensitivity to LiCl toxicity. These results indicate that mGluR7 deficiency causes
an impairment of two distinct amygdala-dependent behavioral paradigms. Immunohistochemical
and immunoelectron-microscopic analyses showed that mGluR7 is highly expressed
in amygdala and preferentially localized at the presynaptic axon terminals of
glutamatergic neurons. Together, these findings strongly suggest that mGluR7 is
involved in neural processes subserving amygdala-dependent averse responses.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan, the Ministry of Health and Welfare of
Japan, the Sankyo Foundation, the Yamanouchi Foundation, and the Biomolecular Engineering
Research Institute. We thank Takashi Yamamoto for advice on CTA experiments, Fumitaka
Ushikubi for advice on the nociception test, Markus Schroeder for back-crossing
of mutant mice, Ayae Kinoshita for the kind gift of antibodies, Akira Uesugi for
photography, and Kumlesh K. Dev for careful reading of this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Miwako
full_name: Masugi, Miwako
last_name: Masugi
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Keiko
full_name: Muguruma, Keiko
last_name: Muguruma
- first_name: Yasuyoshi
full_name: Watanabe, Yasuyoshi
last_name: Watanabe
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Masugi M, Yokoi M, Shigemoto R, et al. Metabotropic glutamate receptor subtype
7 ablation causes deficit in fear response and conditioned taste aversion. Journal
of Neuroscience. 1999;19(3):955-963. doi:10.1523/JNEUROSCI.19-03-00955.1999
apa: Masugi, M., Yokoi, M., Shigemoto, R., Muguruma, K., Watanabe, Y., Sansig, G.,
… Nakanishi, S. (1999). Metabotropic glutamate receptor subtype 7 ablation causes
deficit in fear response and conditioned taste aversion. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-03-00955.1999
chicago: Masugi, Miwako, Mineto Yokoi, Ryuichi Shigemoto, Keiko Muguruma, Yasuyoshi
Watanabe, Gilles Sansig, Herman Van Der Putten, and Shigetada Nakanishi. “Metabotropic
Glutamate Receptor Subtype 7 Ablation Causes Deficit in Fear Response and Conditioned
Taste Aversion.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-03-00955.1999.
ieee: M. Masugi et al., “Metabotropic glutamate receptor subtype 7 ablation
causes deficit in fear response and conditioned taste aversion,” Journal of
Neuroscience, vol. 19, no. 3. Society for Neuroscience, pp. 955–963, 1999.
ista: Masugi M, Yokoi M, Shigemoto R, Muguruma K, Watanabe Y, Sansig G, Van Der
Putten H, Nakanishi S. 1999. Metabotropic glutamate receptor subtype 7 ablation
causes deficit in fear response and conditioned taste aversion. Journal of Neuroscience.
19(3), 955–963.
mla: Masugi, Miwako, et al. “Metabotropic Glutamate Receptor Subtype 7 Ablation
Causes Deficit in Fear Response and Conditioned Taste Aversion.” Journal of
Neuroscience, vol. 19, no. 3, Society for Neuroscience, 1999, pp. 955–63,
doi:10.1523/JNEUROSCI.19-03-00955.1999.
short: M. Masugi, M. Yokoi, R. Shigemoto, K. Muguruma, Y. Watanabe, G. Sansig, H.
Van Der Putten, S. Nakanishi, Journal of Neuroscience 19 (1999) 955–963.
date_created: 2018-12-11T11:58:33Z
date_published: 1999-02-01T00:00:00Z
date_updated: 2023-03-27T10:00:42Z
day: '01'
doi: 10.1523/JNEUROSCI.19-03-00955.1999
extern: '1'
external_id:
pmid:
- '9920659'
intvolume: ' 19'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782134/
month: '02'
oa: 1
oa_version: Published Version
page: 955 - 963
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4306'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response
and conditioned taste aversion
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '2593'
abstract:
- lang: eng
text: In cat and monkey, lamina I cells can be classified into three basic morphological
types (fusiform, pyramidal, and multipolar), and recent intracellular labeling
evidence in the cat indicates that fusiform and multipolar lamina I cells are
two different types of nociceptive cells, whereas pyramidal cells are innocuous
thermoreceptive-specific. Because earlier observations indicated that only nociceptive
dorsal horn neurons respond to substance P (SP), we examined which morphological
types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r-
immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical
and lumbar enlargements of four monkeys. Consistent results were obtained by two
independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%)
or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained
similar findings in three monkeys in which we used double-labeling immunocytochemistry
to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with
cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic
neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal.
In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina
I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate
that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r,
consistent with the idea that both types are nociceptive, whereas only a small
proportion of lamina I pyramidal cells express this receptor, consistent with
the previous finding that they are nonnociceptive. However, these findings also
indicate that not all nociceptive lamina I neurons express receptors for SP.
acknowledgement: This study was supported by National Institute of Health Grants NS
34022 to Y.D.K. and NS 25616 to A.D.C., by Canadian Medical Research Council (MRC)
Grants MT 12942 to Y.D.K. and MT 12170 to A.R.S., and by the Barrow Neurological
Foundation. Y.D.K. is a Scholar of the Canadian MRC. We thank A. Constantin and
A. Forster for expert technical assistance and Dr. M. Wikstrom for generously supplying
monoclonal antibodies against CTb.
article_processing_charge: No
article_type: original
author:
- first_name: Xiao
full_name: Yu, Xiao
last_name: Yu
- first_name: En
full_name: Zhang, En
last_name: Zhang
- first_name: Arthur
full_name: Craig, Arthur
last_name: Craig
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
- first_name: Yves
full_name: De Koninck, Yves
last_name: De Koninck
citation:
ama: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. NK-1
receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord. Journal of Neuroscience. 1999;19(9):3545-3555.
doi:10.1523/JNEUROSCI.19-09-03545.1999
apa: Yu, X., Zhang, E., Craig, A., Shigemoto, R., Ribeiro Da Silva, A., & De
Koninck, Y. (1999). NK-1 receptor immunoreactivity in distinct morphological types
of lamina I neurons of the primate spinal cord. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999
chicago: Yu, Xiao, En Zhang, Arthur Craig, Ryuichi Shigemoto, Alfredo Ribeiro Da
Silva, and Yves De Koninck. “NK-1 Receptor Immunoreactivity in Distinct Morphological
Types of Lamina I Neurons of the Primate Spinal Cord.” Journal of Neuroscience.
Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999.
ieee: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, and Y. De Koninck,
“NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord,” Journal of Neuroscience, vol. 19, no. 9. Society
for Neuroscience, pp. 3545–3555, 1999.
ista: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. 1999.
NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord. Journal of Neuroscience. 19(9), 3545–3555.
mla: Yu, Xiao, et al. “NK-1 Receptor Immunoreactivity in Distinct Morphological
Types of Lamina I Neurons of the Primate Spinal Cord.” Journal of Neuroscience,
vol. 19, no. 9, Society for Neuroscience, 1999, pp. 3545–55, doi:10.1523/JNEUROSCI.19-09-03545.1999.
short: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, Y. De Koninck,
Journal of Neuroscience 19 (1999) 3545–3555.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2023-03-27T09:54:40Z
day: '01'
doi: 10.1523/JNEUROSCI.19-09-03545.1999
extern: '1'
external_id:
pmid:
- '10212314'
intvolume: ' 19'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782224/
month: '05'
oa: 1
oa_version: None
page: 3545 - 3555
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4305'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NK-1 receptor immunoreactivity in distinct morphological types of lamina I
neurons of the primate spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '2594'
abstract:
- lang: eng
text: Substance P receptor (i.e. NK1)-like immunoreactive (SPR-LI) neurons were
observed in the newborn and adult human spinal cord. Substance P receptor-like
immunoreactive neuronal cell bodies were seen most frequently in lamina I, and
were scattered throughout the remaining laminae of the dorsal horn and the area
around the central canal. Some neurons in the intermediolateral nucleus also showed
weak immunoreactivity. The pattern of distribution of SPR-LI neurons in the adult
spinal cord was essentially the same as that in the newborn spinal cord. However,
SPR-LI neurons cell bodies were seen much more frequently in the newborn than
in the adult dorsal horn, especially in lamina II.
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39600045) and the Ministry of Education, Science,
Sports and Culture of Japan (08279106, 09480211, 10164225, 10680701).
article_processing_charge: No
article_type: original
author:
- first_name: Yu
full_name: Ding, Yu
last_name: Ding
- first_name: Heng
full_name: Zheng, Heng
last_name: Zheng
- first_name: Dian
full_name: Wang, Dian
last_name: Wang
- first_name: Jun
full_name: Xu, Jun
last_name: Xu
- first_name: Liang
full_name: Gong, Liang
last_name: Gong
- first_name: Yan
full_name: Lü, Yan
last_name: Lü
- first_name: Bing
full_name: Qin, Bing
last_name: Qin
- first_name: Juan
full_name: Shi, Juan
last_name: Shi
- first_name: Hua
full_name: Li, Hua
last_name: Li
- first_name: Ji
full_name: Li, Ji
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ding Y, Zheng H, Wang D, et al. The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord. Neuroscience
Letters. 1999;266(2):133-136. doi:10.1016/S0304-3940(99)00283-9
apa: Ding, Y., Zheng, H., Wang, D., Xu, J., Gong, L., Lü, Y., … Mizuno, N. (1999).
The distribution of substance P receptor (NK1)-like immunoreactive neurons in
the newborn and adult human spinal cord. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(99)00283-9
chicago: Ding, Yu, Heng Zheng, Dian Wang, Jun Xu, Liang Gong, Yan Lü, Bing Qin,
et al. “The Distribution of Substance P Receptor (NK1)-like Immunoreactive Neurons
in the Newborn and Adult Human Spinal Cord.” Neuroscience Letters. Elsevier,
1999. https://doi.org/10.1016/S0304-3940(99)00283-9.
ieee: Y. Ding et al., “The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord,” Neuroscience
Letters, vol. 266, no. 2. Elsevier, pp. 133–136, 1999.
ista: Ding Y, Zheng H, Wang D, Xu J, Gong L, Lü Y, Qin B, Shi J, Li H, Li J, Shigemoto
R, Kaneko T, Mizuno N. 1999. The distribution of substance P receptor (NK1)-like
immunoreactive neurons in the newborn and adult human spinal cord. Neuroscience
Letters. 266(2), 133–136.
mla: Ding, Yu, et al. “The Distribution of Substance P Receptor (NK1)-like Immunoreactive
Neurons in the Newborn and Adult Human Spinal Cord.” Neuroscience Letters,
vol. 266, no. 2, Elsevier, 1999, pp. 133–36, doi:10.1016/S0304-3940(99)00283-9.
short: Y. Ding, H. Zheng, D. Wang, J. Xu, L. Gong, Y. Lü, B. Qin, J. Shi, H. Li,
J. Li, R. Shigemoto, T. Kaneko, N. Mizuno, Neuroscience Letters 266 (1999) 133–136.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-05-07T00:00:00Z
date_updated: 2022-09-13T10:05:26Z
day: '07'
doi: 10.1016/S0304-3940(99)00283-9
extern: '1'
external_id:
pmid:
- '10353345 '
intvolume: ' 266'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 133 - 136
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4304'
quality_controlled: '1'
status: public
title: The distribution of substance P receptor (NK1)-like immunoreactive neurons
in the newborn and adult human spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 266
year: '1999'
...
---
_id: '2595'
abstract:
- lang: eng
text: Presynaptic metabotropic glutamate receptors (mGluRs) of group III constitute
possible targets for putative neuroprotective drugs acting against glutamate excitotoxic
insults. Indeed, in glutamatergic cerebellar granule neurones in culture, high
concentrations of L-2-amino-4-phosphonobutyrate (L-AP4, above 0.3 mM, thus activating
mGluR7) inhibit NMDA-induced cell death. In contrast, in striatal cultures which
are enriched in GABAergic neurones, we show that high concentrations of L-AP4
increased neuronal death in control as well as in NMDA-stimulated cultures. Moreover,
similar results were obtained with the GABA(B)R agonist, baclofen. Both the neuroprotective
effects in cerebellar granule cells and the neurotoxic effects in striatal neurones
were mediated via Gi-Go-coupled mGluRs, suggesting that these effects were probably
mediated by mGluR7a or b and GABA(B)R expressed in these neurones. In striatal
neurones, we found that L-AP4 and baclofen inhibited both basal and NMDA-stimulated
GABA release. These inhibitions of GABA release may be responsible for the increase
in basal and NMDA-stimulated neuronal death. Indeed, blockade of GABA(A) receptors
with bicuculline increased neuronal death of control and NMDA-treated striatal
cultures. Taken together, these results suggest that L-AP4 and baclofen, via mGluR7
and GABA(B)R, reduced the neuroprotective effect of GABA present in striatal cultures
acting via GABA(A) receptors. Although caution must be taken when extrapolating
from in vitro to in vivo situations, the present experiments and the recent observations
that mGluR7 and GABA(B)R are expressed in heterologous synapses, should be taken
into consideration when evaluating the neuroprotective action of future mGluR7
specific agonists or GABA(B)R specific antagonists.
acknowledgement: "We thank A. Turner-Madeuf for English revision, M. Passama and L.
Charvet for the illustrations, Isabelle Brabet, Cécile Joly and Jaroslav Blahos
for helpful technical assistance. This work was supported by the CNRS, Bayer \r\nFrance/Troponwerke
(Germany), and CEE-Biomed BMH4-2 CT 960228."
article_processing_charge: No
article_type: original
author:
- first_name: Mireille
full_name: Lafon Cazal, Mireille
last_name: Lafon Cazal
- first_name: Gaëlle
full_name: Viennois, Gaëlle
last_name: Viennois
- first_name: Rainer
full_name: Kühn, Rainer
last_name: Kühn
- first_name: Barbara
full_name: Malitschek, Barbara
last_name: Malitschek
- first_name: Jean
full_name: Pin, Jean
last_name: Pin
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Joël
full_name: Bockaërt, Joël
last_name: Bockaërt
citation:
ama: Lafon Cazal M, Viennois G, Kühn R, et al. mGluR7-like receptor and GABA(B)
receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured
mouse striatal GABAergic neurones. Neuropharmacology. 1999;38(10):1631-1640.
doi:10.1016/S0028-3908(99)00124-0
apa: Lafon Cazal, M., Viennois, G., Kühn, R., Malitschek, B., Pin, J., Shigemoto,
R., & Bockaërt, J. (1999). mGluR7-like receptor and GABA(B) receptor activation
enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal
GABAergic neurones. Neuropharmacology. Elsevier. https://doi.org/10.1016/S0028-3908(99)00124-0
chicago: Lafon Cazal, Mireille, Gaëlle Viennois, Rainer Kühn, Barbara Malitschek,
Jean Pin, Ryuichi Shigemoto, and Joël Bockaërt. “MGluR7-like Receptor and GABA(B)
Receptor Activation Enhance Neurotoxic Effects of N-Methyl-D-Aspartate in Cultured
Mouse Striatal GABAergic Neurones.” Neuropharmacology. Elsevier, 1999.
https://doi.org/10.1016/S0028-3908(99)00124-0.
ieee: M. Lafon Cazal et al., “mGluR7-like receptor and GABA(B) receptor activation
enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal
GABAergic neurones,” Neuropharmacology, vol. 38, no. 10. Elsevier, pp.
1631–1640, 1999.
ista: Lafon Cazal M, Viennois G, Kühn R, Malitschek B, Pin J, Shigemoto R, Bockaërt
J. 1999. mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic
effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones.
Neuropharmacology. 38(10), 1631–1640.
mla: Lafon Cazal, Mireille, et al. “MGluR7-like Receptor and GABA(B) Receptor Activation
Enhance Neurotoxic Effects of N-Methyl-D-Aspartate in Cultured Mouse Striatal
GABAergic Neurones.” Neuropharmacology, vol. 38, no. 10, Elsevier, 1999,
pp. 1631–40, doi:10.1016/S0028-3908(99)00124-0.
short: M. Lafon Cazal, G. Viennois, R. Kühn, B. Malitschek, J. Pin, R. Shigemoto,
J. Bockaërt, Neuropharmacology 38 (1999) 1631–1640.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-13T08:23:20Z
day: '01'
doi: 10.1016/S0028-3908(99)00124-0
extern: '1'
external_id:
pmid:
- '10530824 '
intvolume: ' 38'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 1631 - 1640
pmid: 1
publication: Neuropharmacology
publication_identifier:
issn:
- 0028-3908
publication_status: published
publisher: Elsevier
publist_id: '4302'
quality_controlled: '1'
scopus_import: '1'
status: public
title: mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects
of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 38
year: '1999'
...
---
_id: '2596'
abstract:
- lang: eng
text: "A γ-aminobutyric acid (GABA)(B) receptor (named GABA(B)R1) has been recently
cloned in the rat and human brain and two variants generated by alternative RNA
splicing were identified. In the present study, we addressed the question as to
whether these variants contribute to the diversity of GABA(B) receptor-mediated
physiological responses and constitute real receptor subtypes with distinct functions.
To this aim, we have mapped the GABA(B)R1 (R1a) and GABA(B)R1b (R1b) transcript
distribution in the rat brain using in situ hybridization. We have compared the
mRNA distribution with the distribution of [ 3H]CGP54626-labeled binding GABA(B)R1
receptor sites as assessed in adjacent cryosections by quantitative autoradiography.
We found that GABA(B) receptor transcripts and binding sites are expressed in
the brain in almost all neuronal cell populations. Expression in glial cells,
if any, is marginal. We observed a good parallelism between GABA(B)R1 mRNA transcripts
and binding sites in broad neuroanatomical entities with highest densities in
hippocampus, thalamic nuclei, and cerebellum. By contrast, R1a and R1b transcripts
exhibit marked differences in their regional and cellular distribution pattern.
A typical example is the cerebellum with an almost exclusive expression of R1b
in the Purkinje cells and of R1a in the granule, stellate, and basket cells. Data
pointing at a pre- versus postsynaptic localization for R1a and R1b, respectively,
at some neuronal sites are presented.\r\n"
acknowledgement: We thank W. Froestl and S.J. Mickel for synthesis of GABAB ligands,
and H. van der Putten for helpful discussions. Many thanks to S. Pfister (former
graduate student in our group), and P. Dreja, M. Kohler, P. Schwarb, P.Kaindl (Carl
Zeiss A.G., Zurich, Switzerland) for their help in the design of computer macros
for the quantitative analysis of in situ hybridization sections. The critical review
of the manuscript by J. Mosbacher (NovartisPharma, TA Nervous System) and J. Koenig
(Maryland Psychiatric Research Center, Baltimore, MD) are gratefully acknowledged.
article_processing_charge: No
article_type: original
author:
- first_name: Serge
full_name: Bischoff, Serge
last_name: Bischoff
- first_name: Sabine
full_name: Leonhard, Sabine
last_name: Leonhard
- first_name: Nicole
full_name: Reymann, Nicole
last_name: Reymann
- first_name: Valérie
full_name: Schuler, Valérie
last_name: Schuler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Klemens
full_name: Kaupmann, Klemens
last_name: Kaupmann
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
citation:
ama: Bischoff S, Leonhard S, Reymann N, et al. Spatial distribution of GABA(B)R1
receptor mRNA and binding sites in the rat brain^. Journal of Comparative Neurology.
1999;412(1):1-16. doi:10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D
apa: Bischoff, S., Leonhard, S., Reymann, N., Schuler, V., Shigemoto, R., Kaupmann,
K., & Bettler, B. (1999). Spatial distribution of GABA(B)R1 receptor mRNA
and binding sites in the rat brain^. Journal of Comparative Neurology.
Wiley-Blackwell. https://doi.org/10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D
chicago: Bischoff, Serge, Sabine Leonhard, Nicole Reymann, Valérie Schuler, Ryuichi
Shigemoto, Klemens Kaupmann, and Bernhard Bettler. “Spatial Distribution of GABA(B)R1
Receptor MRNA and Binding Sites in the Rat Brain^.” Journal of Comparative
Neurology. Wiley-Blackwell, 1999. https://doi.org/10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D.
ieee: S. Bischoff et al., “Spatial distribution of GABA(B)R1 receptor mRNA
and binding sites in the rat brain^,” Journal of Comparative Neurology,
vol. 412, no. 1. Wiley-Blackwell, pp. 1–16, 1999.
ista: Bischoff S, Leonhard S, Reymann N, Schuler V, Shigemoto R, Kaupmann K, Bettler
B. 1999. Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in
the rat brain^. Journal of Comparative Neurology. 412(1), 1–16.
mla: Bischoff, Serge, et al. “Spatial Distribution of GABA(B)R1 Receptor MRNA and
Binding Sites in the Rat Brain^.” Journal of Comparative Neurology, vol.
412, no. 1, Wiley-Blackwell, 1999, pp. 1–16, doi:10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D.
short: S. Bischoff, S. Leonhard, N. Reymann, V. Schuler, R. Shigemoto, K. Kaupmann,
B. Bettler, Journal of Comparative Neurology 412 (1999) 1–16.
date_created: 2018-12-11T11:58:35Z
date_published: 1999-09-13T00:00:00Z
date_updated: 2022-09-13T08:30:25Z
day: '13'
doi: 10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D
extern: '1'
external_id:
pmid:
- '10440706 '
intvolume: ' 412'
issue: '1'
language:
- iso: eng
month: '09'
oa_version: None
page: 1 - 16
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4303'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat
brain^
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 412
year: '1999'
...
---
_id: '2597'
abstract:
- lang: eng
text: Metabotropic glutamate receptors (mGlus) are known to modulate synaptic transmission
in various pathways of the central nervous system, but the exact mechanisms by
which this modulation occurs remain unclear. Here we utilise electrophysiological
and immunocytochemical techniques on cultured autaptic hippocampal neurones to
investigate the mechanism of action and distribution of mGlus. Agonists at all
three groups of mGlus depressed glutamatergic transmission, whereas only agonists
at group I mGlus depressed GABAergic transmission. Agonists at all mGlus failed
to modulate Ca2+ and K+ channels in glutamatergic autapses whereas an agonist
at group III mGlus did depress the frequency of miniature excitatory postsynaptic
currents (mEPSCs). Agonists failed to modulate Ca2+ or K+ channels and miniature
inhibitory postsynaptic currents (mIPSCs) in GABAergic autapses. Distribution
studies using selective antibodies revealed punctate staining for group III mGlus
that co-localised with the synaptic marker, synaptophysin. Staining for the remaining
mGlus was more diffuse throughout the soma and processes with little co-localisation
with synaptophysin. The distribution of the group III receptors is consistent
with the direct 'downstream' modulation of mEPSCs, although the exact mechanism
of action for the remaining receptors remains unclear.
acknowledgement: This work was supported by a Wellcome International Travel Fellowship
to TJB and by the Public Service Grants DA02121, MH40165, NS33502 and NS33826 for
CCL and RJM. We are grateful to Dr Graeme I. Bell for use of his microscope for
the antibody studies.
article_processing_charge: No
article_type: original
author:
- first_name: Trevor
full_name: Bushell, Trevor
last_name: Bushell
- first_name: Chong
full_name: Lee, Chong
last_name: Lee
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Richard
full_name: Miller, Richard
last_name: Miller
citation:
ama: Bushell T, Lee C, Shigemoto R, Miller R. Modulation of synaptic transmission
and differential localisation of mGlus in cultured hippocampal autapses. Neuropharmacology.
1999;38(10):1553-1567. doi:10.1016/S0028-3908(99)00103-3
apa: Bushell, T., Lee, C., Shigemoto, R., & Miller, R. (1999). Modulation of
synaptic transmission and differential localisation of mGlus in cultured hippocampal
autapses. Neuropharmacology. Elsevier. https://doi.org/10.1016/S0028-3908(99)00103-3
chicago: Bushell, Trevor, Chong Lee, Ryuichi Shigemoto, and Richard Miller. “Modulation
of Synaptic Transmission and Differential Localisation of MGlus in Cultured Hippocampal
Autapses.” Neuropharmacology. Elsevier, 1999. https://doi.org/10.1016/S0028-3908(99)00103-3.
ieee: T. Bushell, C. Lee, R. Shigemoto, and R. Miller, “Modulation of synaptic transmission
and differential localisation of mGlus in cultured hippocampal autapses,” Neuropharmacology,
vol. 38, no. 10. Elsevier, pp. 1553–1567, 1999.
ista: Bushell T, Lee C, Shigemoto R, Miller R. 1999. Modulation of synaptic transmission
and differential localisation of mGlus in cultured hippocampal autapses. Neuropharmacology.
38(10), 1553–1567.
mla: Bushell, Trevor, et al. “Modulation of Synaptic Transmission and Differential
Localisation of MGlus in Cultured Hippocampal Autapses.” Neuropharmacology,
vol. 38, no. 10, Elsevier, 1999, pp. 1553–67, doi:10.1016/S0028-3908(99)00103-3.
short: T. Bushell, C. Lee, R. Shigemoto, R. Miller, Neuropharmacology 38 (1999)
1553–1567.
date_created: 2018-12-11T11:58:35Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-13T08:15:55Z
day: '01'
doi: 10.1016/S0028-3908(99)00103-3
extern: '1'
external_id:
pmid:
- '10530817'
intvolume: ' 38'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 1553 - 1567
pmid: 1
publication: Neuropharmacology
publication_identifier:
issn:
- 0028-3908
publication_status: published
publisher: Elsevier
publist_id: '4301'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modulation of synaptic transmission and differential localisation of mGlus
in cultured hippocampal autapses
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 38
year: '1999'
...
---
_id: '2711'
abstract:
- lang: eng
text: We study the long time evolution of a quantum particle in a Gaussian random
environment. We show that in the weak coupling limit the Wigner distribution of
the wave function converges to the solution of a linear Boltzmann equation globally
in time. The Boltzmann collision kernel is given by the Born approximation of
the quantum scattering cross section.
alternative_title:
- 'Operator Theory: Advances and Applications'
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Linear Boltzmann equation as the weak coupling limit of the random
Schrödinger equation. In: Proceedings of the 7th QMath Conference. Vol
108. World Scientific Publishing; 1999:233-242. doi:10.1007/978-3-0348-8745-8_20'
apa: 'Erdös, L. (1999). Linear Boltzmann equation as the weak coupling limit of
the random Schrödinger equation. In Proceedings of the 7th QMath Conference
(Vol. 108, pp. 233–242). Prague, Czech Republik: World Scientific Publishing.
https://doi.org/10.1007/978-3-0348-8745-8_20'
chicago: Erdös, László. “Linear Boltzmann Equation as the Weak Coupling Limit of
the Random Schrödinger Equation.” In Proceedings of the 7th QMath Conference,
108:233–42. World Scientific Publishing, 1999. https://doi.org/10.1007/978-3-0348-8745-8_20.
ieee: L. Erdös, “Linear Boltzmann equation as the weak coupling limit of the random
Schrödinger equation,” in Proceedings of the 7th QMath Conference, Prague,
Czech Republik, 1999, vol. 108, pp. 233–242.
ista: 'Erdös L. 1999. Linear Boltzmann equation as the weak coupling limit of the
random Schrödinger equation. Proceedings of the 7th QMath Conference. QMath: Mathematical
Results in Quantum Physics, Operator Theory: Advances and Applications, vol. 108,
233–242.'
mla: Erdös, László. “Linear Boltzmann Equation as the Weak Coupling Limit of the
Random Schrödinger Equation.” Proceedings of the 7th QMath Conference,
vol. 108, World Scientific Publishing, 1999, pp. 233–42, doi:10.1007/978-3-0348-8745-8_20.
short: L. Erdös, in:, Proceedings of the 7th QMath Conference, World Scientific
Publishing, 1999, pp. 233–242.
conference:
end_date: 1999-09-26
location: Prague, Czech Republik
name: 'QMath: Mathematical Results in Quantum Physics'
start_date: 1998-06-22
date_created: 2018-12-11T11:59:12Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-13T08:02:52Z
day: '01'
doi: 10.1007/978-3-0348-8745-8_20
extern: '1'
intvolume: ' 108'
language:
- iso: eng
month: '01'
oa_version: None
page: 233 - 242
publication: Proceedings of the 7th QMath Conference
publication_identifier:
isbn:
- '9783034897549'
publication_status: published
publisher: World Scientific Publishing
publist_id: '4185'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linear Boltzmann equation as the weak coupling limit of the random Schrödinger
equation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '1999'
...
---
_id: '2730'
abstract:
- lang: eng
text: We give the leading order semiclassical asymptotics for the sum of the negative
eigenvalues of the Pauli operator (in dimension two and three) with a strong non-homogeneous
magnetic field. This result can be used to prove that the magnetic Thomas-Fermi
theory gives the leading order ground state energy of large atoms. We develop
a new localization scheme well suited to the anisotropic character of the strong
magnetic field. We also use the basic Lieb-Thirring estimate obtained earlier
(1996). (orig.) 19 refs.
acknowledgement: The first author gratefully acknowledges financial support from the
Eidgen6ssiche Technische Hochschule, Forschungsinstitut für Mathematik, Zürich,
where this work was started. He is also grateful for the hospitality and support
of Aarhus University during his visits there.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: 'Erdös L, Solovej J. Semiclassical eigenvalue estimates for the Pauli operator
with strong nonhomogeneous magnetic fields, I: Nonasymptotic Lieb-Thirring-type
estimate. Duke Mathematical Journal. 1999;96(1):127-173. doi:10.1215/S0012-7094-99-09604-7'
apa: 'Erdös, L., & Solovej, J. (1999). Semiclassical eigenvalue estimates for
the Pauli operator with strong nonhomogeneous magnetic fields, I: Nonasymptotic
Lieb-Thirring-type estimate. Duke Mathematical Journal. Duke University
Press. https://doi.org/10.1215/S0012-7094-99-09604-7'
chicago: 'Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for
the Pauli Operator with Strong Nonhomogeneous Magnetic Fields, I: Nonasymptotic
Lieb-Thirring-Type Estimate.” Duke Mathematical Journal. Duke University
Press, 1999. https://doi.org/10.1215/S0012-7094-99-09604-7.'
ieee: 'L. Erdös and J. Solovej, “Semiclassical eigenvalue estimates for the Pauli
operator with strong nonhomogeneous magnetic fields, I: Nonasymptotic Lieb-Thirring-type
estimate,” Duke Mathematical Journal, vol. 96, no. 1. Duke University Press,
pp. 127–173, 1999.'
ista: 'Erdös L, Solovej J. 1999. Semiclassical eigenvalue estimates for the Pauli
operator with strong nonhomogeneous magnetic fields, I: Nonasymptotic Lieb-Thirring-type
estimate. Duke Mathematical Journal. 96(1), 127–173.'
mla: 'Erdös, László, and Jan Solovej. “Semiclassical Eigenvalue Estimates for the
Pauli Operator with Strong Nonhomogeneous Magnetic Fields, I: Nonasymptotic Lieb-Thirring-Type
Estimate.” Duke Mathematical Journal, vol. 96, no. 1, Duke University Press,
1999, pp. 127–73, doi:10.1215/S0012-7094-99-09604-7.'
short: L. Erdös, J. Solovej, Duke Mathematical Journal 96 (1999) 127–173.
date_created: 2018-12-11T11:59:18Z
date_published: 1999-01-15T00:00:00Z
date_updated: 2023-02-20T07:34:48Z
day: '15'
doi: 10.1215/S0012-7094-99-09604-7
extern: '1'
intvolume: ' 96'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 127 - 173
publication: Duke Mathematical Journal
publication_identifier:
issn:
- 0012-7094
publication_status: published
publisher: Duke University Press
publist_id: '4162'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Semiclassical eigenvalue estimates for the Pauli operator with strong nonhomogeneous
magnetic fields, I: Nonasymptotic Lieb-Thirring-type estimate'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '1999'
...
---
_id: '2783'
abstract:
- lang: eng
text: Pattern formation in a layer of fluid heated from below is an example of macroscopic
ordering in continuous media. Here we show that in a relatively compact experimental
version of the problem, a rich and diverse set of stable flows can be found. These
flows, many of which are novel, can be categorized and understood in terms of
their symmetry properties. This approach shows promise for providing insight into
the more complicated fluid motion that occurs as the lateral dimension of the
layer is increased.
article_processing_charge: No
article_type: original
author:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Peter
full_name: Lucas, Peter
last_name: Lucas
- first_name: Tom
full_name: Mullin, Tom
last_name: Mullin
citation:
ama: Hof B, Lucas P, Mullin T. Flow state multiplicity in convection. Physics
of Fluids. 1999;11(10):2815-2817. doi:10.1063/1.870178
apa: Hof, B., Lucas, P., & Mullin, T. (1999). Flow state multiplicity in convection.
Physics of Fluids. American Institute of Physics. https://doi.org/10.1063/1.870178
chicago: Hof, Björn, Peter Lucas, and Tom Mullin. “Flow State Multiplicity in Convection.”
Physics of Fluids. American Institute of Physics, 1999. https://doi.org/10.1063/1.870178 .
ieee: B. Hof, P. Lucas, and T. Mullin, “Flow state multiplicity in convection,”
Physics of Fluids, vol. 11, no. 10. American Institute of Physics, pp.
2815–2817, 1999.
ista: Hof B, Lucas P, Mullin T. 1999. Flow state multiplicity in convection. Physics
of Fluids. 11(10), 2815–2817.
mla: Hof, Björn, et al. “Flow State Multiplicity in Convection.” Physics of Fluids,
vol. 11, no. 10, American Institute of Physics, 1999, pp. 2815–17, doi:10.1063/1.870178 .
short: B. Hof, P. Lucas, T. Mullin, Physics of Fluids 11 (1999) 2815–2817.
date_created: 2018-12-11T11:59:34Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-09T09:24:10Z
day: '01'
doi: '10.1063/1.870178 '
extern: '1'
intvolume: ' 11'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 2815 - 2817
publication: Physics of Fluids
publication_identifier:
issn:
- 0031-9171
publication_status: published
publisher: American Institute of Physics
publist_id: '4106'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Flow state multiplicity in convection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...
---
_id: '2864'
abstract:
- lang: eng
text: Using an electrospray tandem mass spectrometer as a concentration-sensitive
detector, a method has been developed to quantify femtomole amounts of plant growth
regulators (i.e. isoprenoid type cytokinins, zeatin, dihydrozeatin, isopentenyladenine
and their respective riboside and glucoside analogues) and the second messenger
adenosine 3':5'-cyclic monophosphate (3':5'-cAMP). Miniaturisation of the chromatographic
setup using capillary high performance liquid chromatographic (HPLC) ion spray
mass spectrometry increased the sensitivity to the low femtomole region. Application
of automated capillary column switching allowed the introduction of large injection
volumes into the HPLC system. Aliquots (25 μL) were injected into one dimension
of the HPLC set-up and stacked onto a micro pre-column. By means of mobile phase
switching the pre-column was back-flushed to introduce the analytes onto the analytical
column. For cytokinin analysis positive electrospray ionisation was used and resulted
in 2.5-25 fmol detection limits. Cyclic nucleotides were separated under ion-pair
conditions using tetrabutyl ammonium bromide as ion-pair reagent and were detected
under negative electrospray ionisation conditions. Here a 25 fmol detection limit
was determined. Following this approach, cytokinins and 3':5'-cAMP extracted from
only mg amounts of apical shoot meristem and chloroplasts obtained from Nicotiana
tabacum cv. Petit Havana SR1 were identified and quantified.
acknowledgement: The authors wish to thank J. Dupon for technical and logisticalassistance.
The authors also wish to thank the FWO-Vlaanderen/lotto (grant 32013394), the Flemish government (GOA-action) and the
Grant Agency of the Czech Republic (grant 206/96/K188) for financial support.
article_processing_charge: No
article_type: original
author:
- first_name: Erwin
full_name: Witters, Erwin
last_name: Witters
- first_name: Koen
full_name: Vanhoutte, Koen
last_name: Vanhoutte
- first_name: Walter
full_name: Dewitte, Walter
last_name: Dewitte
- first_name: Ivana
full_name: Macháčková, Ivana
last_name: Macháčková
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Walter
full_name: Van Dongen, Walter
last_name: Van Dongen
- first_name: Eddy
full_name: Esmans, Eddy
last_name: Esmans
- first_name: Henri
full_name: Van Onckelen, Henri
last_name: Van Onckelen
citation:
ama: Witters E, Vanhoutte K, Dewitte W, et al. Analysis of cyclic nucleotides and
cytokinins in minute plant samples using phase system switching capillary electrospray
liquid chromatography tandem mass spectrometry. Phytochemical Analysis.
1999;10(3):143-151. doi:10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
apa: Witters, E., Vanhoutte, K., Dewitte, W., Macháčková, I., Benková, E., Van Dongen,
W., … Van Onckelen, H. (1999). Analysis of cyclic nucleotides and cytokinins in
minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry. Phytochemical Analysis. Wiley-Blackwell.
https://doi.org/10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
chicago: Witters, Erwin, Koen Vanhoutte, Walter Dewitte, Ivana Macháčková, Eva Benková,
Walter Van Dongen, Eddy Esmans, and Henri Van Onckelen. “Analysis of Cyclic Nucleotides
and Cytokinins in Minute Plant Samples Using Phase System Switching Capillary
Electrospray Liquid Chromatography Tandem Mass Spectrometry.” Phytochemical
Analysis. Wiley-Blackwell, 1999. https://doi.org/10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G.
ieee: E. Witters et al., “Analysis of cyclic nucleotides and cytokinins in
minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry,” Phytochemical Analysis, vol.
10, no. 3. Wiley-Blackwell, pp. 143–151, 1999.
ista: Witters E, Vanhoutte K, Dewitte W, Macháčková I, Benková E, Van Dongen W,
Esmans E, Van Onckelen H. 1999. Analysis of cyclic nucleotides and cytokinins
in minute plant samples using phase system switching capillary electrospray liquid
chromatography tandem mass spectrometry. Phytochemical Analysis. 10(3), 143–151.
mla: Witters, Erwin, et al. “Analysis of Cyclic Nucleotides and Cytokinins in Minute
Plant Samples Using Phase System Switching Capillary Electrospray Liquid Chromatography
Tandem Mass Spectrometry.” Phytochemical Analysis, vol. 10, no. 3, Wiley-Blackwell,
1999, pp. 143–51, doi:10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G.
short: E. Witters, K. Vanhoutte, W. Dewitte, I. Macháčková, E. Benková, W. Van Dongen,
E. Esmans, H. Van Onckelen, Phytochemical Analysis 10 (1999) 143–151.
date_created: 2018-12-11T12:00:00Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2022-09-09T09:09:22Z
day: '01'
doi: 10.1002/(SICI)1099-1565(199905/06)10:3<143::AID-PCA441>3.0.CO;2-G
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 143 - 151
publication: Phytochemical Analysis
publication_identifier:
issn:
- 0958-0344
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of cyclic nucleotides and cytokinins in minute plant samples using
phase system switching capillary electrospray liquid chromatography tandem mass
spectrometry
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1999'
...
---
_id: '2865'
abstract:
- lang: eng
text: 'Although cytokinins (CKs) affect a number of processes connected with chloroplasts,
it has never been rigorously proven that chloroplasts contain CKs. We isolated
intact chloroplasts from tobacco (Nicotiana tabacum L. cv SR1) and wheat (Triticum
aestivum L. cv Ritmo) leaves and determined their CKs by liquid chromatography/tandem
mass spectroscopy. Chloroplasts from both species contained a whole spectrum of
CKs, including free bases (zeatin and isopentenyladenine), ribosides (zeatin riboside,
and isopentenyladenosine), ribotides (isopentenyladenosine-5′-monophosphate, zeatin
riboside-5′-monophosphate, and dihydrozeatin riboside-5′-monophosphate), and N-glucosides
(zeatin-N 9-glucoside, dihydrozeatin-N 9-glucoside, zeatin-N 7-glucoside, and
isopentenyladenine-N-glucosides). In chloroplasts there was a moderately higher
relative amount of bases, ribosides, and ribotides than in leaves, and a significantly
increased level ofN 9-glucosides of zeatin and dihydrozeatin. Tobacco and wheat
chloroplasts were prepared from leaves at the end of either a dark or light period.
After a dark period, chloroplasts accumulated more CKs than after a light period.
The differences were moderate for free bases and ribosides, but highly significant
for glucosides. Tobacco chloroplasts from dark-treated leaves contained zeatin
riboside-O-glucoside and dihydrozeatin riboside-O-glucoside, as well as a relatively
high CK oxidase activity. These data show that chloroplasts contain a whole spectrum
of CKs and the enzymatic activity necessary for their metabolism. '
acknowledgement: The authors thank Prof. Dennis Baker (Wye College, London) and Dr.
Laura Zonia (Institute of Experimental Botany, Prague) for language correction of
the manuscript and Prof. Miroslav Kamínek (Institute of Experimental Botany, Prague)
for critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Erwin
full_name: Witters, Erwin
last_name: Witters
- first_name: Walter
full_name: Van Dongen, Walter
last_name: Van Dongen
- first_name: Jan
full_name: Kolář, Jan
last_name: Kolář
- first_name: Václav
full_name: Motyka, Václav
last_name: Motyka
- first_name: Břetislav
full_name: Brzobohatý, Břetislav
last_name: Brzobohatý
- first_name: Henri
full_name: Van Onckelen, Henri
last_name: Van Onckelen
- first_name: Ivana
full_name: Macháčková, Ivana
last_name: Macháčková
citation:
ama: Benková E, Witters E, Van Dongen W, et al. Cytokinins in tobacco and wheat
chloroplasts. Occurrence and changes due to light/dark treatment. Plant Physiology.
1999;121(1):245-251. doi:10.1104/pp.121.1.245
apa: Benková, E., Witters, E., Van Dongen, W., Kolář, J., Motyka, V., Brzobohatý,
B., … Macháčková, I. (1999). Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. American Society
of Plant Biologists. https://doi.org/10.1104/pp.121.1.245
chicago: Benková, Eva, Erwin Witters, Walter Van Dongen, Jan Kolář, Václav Motyka,
Břetislav Brzobohatý, Henri Van Onckelen, and Ivana Macháčková. “Cytokinins in
Tobacco and Wheat Chloroplasts. Occurrence and Changes Due to Light/Dark Treatment.”
Plant Physiology. American Society of Plant Biologists, 1999. https://doi.org/10.1104/pp.121.1.245.
ieee: E. Benková et al., “Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment,” Plant Physiology, vol. 121, no.
1. American Society of Plant Biologists, pp. 245–251, 1999.
ista: Benková E, Witters E, Van Dongen W, Kolář J, Motyka V, Brzobohatý B, Van Onckelen
H, Macháčková I. 1999. Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. 121(1), 245–251.
mla: Benková, Eva, et al. “Cytokinins in Tobacco and Wheat Chloroplasts. Occurrence
and Changes Due to Light/Dark Treatment.” Plant Physiology, vol. 121, no.
1, American Society of Plant Biologists, 1999, pp. 245–51, doi:10.1104/pp.121.1.245.
short: E. Benková, E. Witters, W. Van Dongen, J. Kolář, V. Motyka, B. Brzobohatý,
H. Van Onckelen, I. Macháčková, Plant Physiology 121 (1999) 245–251.
date_created: 2018-12-11T12:00:00Z
date_published: 1999-09-01T00:00:00Z
date_updated: 2022-09-07T13:56:12Z
day: '01'
doi: 10.1104/pp.121.1.245
extern: '1'
external_id:
pmid:
- '10482680'
intvolume: ' 121'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59373/
month: '09'
oa: 1
oa_version: Published Version
page: 245 - 251
pmid: 1
publication: Plant Physiology
publication_identifier:
issn:
- 0032-0889
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3924'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinins in tobacco and wheat chloroplasts. Occurrence and changes due to
light/dark treatment
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 121
year: '1999'
...
---
_id: '3137'
abstract:
- lang: eng
text: This volume provides an overview of glutamate receptors and their role in
excitatory neurotransmission. It focusses on three aspects. First, it describes
the functional, molecular, and pharmacological properties of glutamate receptors
(AMPA, NMDA, and kainate receptors). Second, it gives a survey how these receptors
are involved in synaptic transmission at different glutamatergic synapses in the
mammalian CNS. Finally, it adresses how overactivation of glutamate receptors
can lead to excitotoxic cell death, and emphasizes the importance of glutamate
receptors as potential therapeutical targets. The chapters, written by leading
scientists, give accurate summaries of facets that have emerged recently in this
field. The book demonstrates the strength of a multidisciplinary approach involving
physiology, pharmacology, and molecular biology. It will be useful for other scientists
in and outside the field, lecturers and students at different educational levels.
alternative_title:
- Handbook of Experimental Pharmacology
article_processing_charge: No
citation:
ama: 'Jonas PM, Monyer H, eds. Ionotropic Glutamate Receptors in the CNS.
Vol 141. 1st ed. Berlin ; Heidelberg: Springer; 1999. doi:10.1007/978-3-662-08022-1'
apa: 'Jonas, P. M., & Monyer, H. (Eds.). (1999). Ionotropic Glutamate Receptors
in the CNS (1st ed., Vol. 141). Berlin ; Heidelberg: Springer. https://doi.org/10.1007/978-3-662-08022-1'
chicago: 'Jonas, Peter M, and Hannah Monyer, eds. Ionotropic Glutamate Receptors
in the CNS. 1st ed. Vol. 141. Berlin ; Heidelberg: Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1.'
ieee: 'P. M. Jonas and H. Monyer, Eds., Ionotropic Glutamate Receptors in the
CNS, 1st ed., vol. 141. Berlin ; Heidelberg: Springer, 1999.'
ista: 'Jonas PM, Monyer H eds. 1999. Ionotropic Glutamate Receptors in the CNS 1st
ed., Berlin ; Heidelberg: Springer, XXII, 535p.'
mla: Jonas, Peter M., and Hannah Monyer, editors. Ionotropic Glutamate Receptors
in the CNS. 1st ed., vol. 141, Springer, 1999, doi:10.1007/978-3-662-08022-1.
short: P.M. Jonas, H. Monyer, eds., Ionotropic Glutamate Receptors in the CNS, 1st
ed., Springer, Berlin ; Heidelberg, 1999.
date_created: 2018-12-11T12:01:36Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2021-12-22T11:13:43Z
day: '01'
doi: 10.1007/978-3-662-08022-1
edition: '1'
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
main_file_link:
- url: http://www.springer.com/biomed/pharmaceutical+science/book/978-3-540-66120-7
month: '01'
oa_version: None
page: XXII, 535
place: Berlin ; Heidelberg
publication_identifier:
eisbn:
- 978-3-662-08022-1
eissn:
- 1865-0325
isbn:
- 978-3-642-08539-0
issn:
- 0171-2004
publication_status: published
publisher: Springer
publist_id: '3560'
quality_controlled: '1'
status: public
title: Ionotropic Glutamate Receptors in the CNS
type: book_editor
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 141
year: '1999'
...
---
_id: '3148'
abstract:
- lang: eng
text: Accurate proteolytic processing of neuropeptide and peptide hormone precursors
by members of the kexin/furin family of proteases is key to determining both the
identities and activities of signaling peptides. Here we identify amontillado
(amon), the Drosophila melanogaster homolog of the mammalian neuropeptide processing
protease PC2, and show that in contrast to vertebrate PC2, amontillado expression
undergoes extensive regulation in the nervous system during development. In situ
hybridization reveals that expression of amontillado is restricted to the final
stages of embryogenesis when it is found in anterior sensory structures and in
only 168 cells in the brain and ventral nerve cord. After larvae hatch from their
egg shells, the sensory structures and most cells in the CNS turn off or substantially
reduce amontillado expression, suggesting that amontillado plays a specific role
late in embryogenesis. Larvae lacking the chromosomal region containing amontillado
show no gross anatomical defects and respond to touch. However, such larvae show
a greatly reduced frequency of a hatching behavior of wild- type Drosophila in
which larvae swing their heads, scraping through the eggshell with their mouth
hooks. Ubiquitous expression of amontillado can restore near wild-type levels
of this behavior, whereas expression of amontillado with an alanine substitution
for the catalytic histidine cannot. These results suggest that amontillado expression
is regulated as part of a programmed modulation of neural signaling that controls
hatching behavior by producing specific neuropeptides in particular neurons at
an appropriate developmental time.
acknowledgement: This research was supported by National Institutes of Health Grant
GM39697 to R.S.F. D.S. was supported in part by National Institutes of Health training
Grant 2T32GM07599. We thank M. A. Krasnow and members of his laboratory, particularly
J. Jarecki, for technical guidance, encouragement, and stimulating scientific discussions.
We thank A. Maghbouleh and the Stanford Statistics Department Consulting Service
for help with statistical analysis. We thank G. Beitel, S. Dietrich, K. Guillemin,
D. Micklem, Y. Nakajima, and members of the Fuller and Krasnow laboratories for
comments on this manuscript. We thank M. Palazzolo for the use of theDrosophila
head cDNA library, D. Kiehart for the use of a Drosophila myosin antibody, and D.
Casso, F.-A. Ramirez-Weber, and T. B. Kornberg for use of the D/TM3SbKrGFP flies.
We thank A. R. Kidd, D. Tolla, and M. Bender and D. Casso, F.-A. Ramirez-Weber and
T. B. Kornberg for communication of results before publication
article_processing_charge: No
article_type: original
author:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
citation:
ama: Siekhaus DE, Fuller R. A role for amontillado the Drosophila homolog of the
neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 1999;19(16):6942-6954. doi:10.1523/jneurosci.19-16-06942.1999
apa: Siekhaus, D. E., & Fuller, R. (1999). A role for amontillado the Drosophila
homolog of the neuropeptide precursor processing protease PC2 in triggering hatching
behavior. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/jneurosci.19-16-06942.1999
chicago: Siekhaus, Daria E, and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/jneurosci.19-16-06942.1999.
ieee: D. E. Siekhaus and R. Fuller, “A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior,”
Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, pp.
6942–6954, 1999.
ista: Siekhaus DE, Fuller R. 1999. A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 19(16), 6942–6954.
mla: Siekhaus, Daria E., and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience,
1999, pp. 6942–54, doi:10.1523/jneurosci.19-16-06942.1999.
short: D.E. Siekhaus, R. Fuller, Journal of Neuroscience 19 (1999) 6942–6954.
date_created: 2018-12-11T12:01:40Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:48:41Z
day: '15'
doi: 10.1523/jneurosci.19-16-06942.1999
extern: '1'
external_id:
pmid:
- '10436051 '
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782853/
month: '08'
oa: 1
oa_version: Published Version
page: 6942 - 6954
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '3547'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A role for amontillado the Drosophila homolog of the neuropeptide precursor
processing protease PC2 in triggering hatching behavior
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '11679'
abstract:
- lang: eng
text: "We are given a set T = {T 1 ,T 2 , . . .,T k } of rooted binary trees, each
T i leaf-labeled by a subset L(Ti)⊂{1,2,...,n} . If T is a tree on {1,2, . . .,n
}, we let T|L denote the minimal subtree of T induced by the nodes of L and all
their ancestors. The consensus tree problem asks whether there exists a tree T
* such that, for every i , T∗|L(Ti) is homeomorphic to T i .\r\n\r\nWe present
algorithms which test if a given set of trees has a consensus tree and if so,
construct one. The deterministic algorithm takes time min{O(N n 1/2 ), O(N+ n
2 log n )}, where N=∑i|Ti| , and uses linear space. The randomized algorithm takes
time O(N log3 n) and uses linear space. The previous best for this problem was
a 1981 O(Nn) algorithm by Aho et al. Our faster deterministic algorithm uses a
new efficient algorithm for the following interesting dynamic graph problem: Given
a graph G with n nodes and m edges and a sequence of b batches of one or more
edge deletions, then, after each batch, either find a new component that has just
been created or determine that there is no such component. For this problem, we
have a simple algorithm with running time O(n 2 log n + b 0 min{n 2 , m log n
}), where b 0 is the number of batches which do not result in a new component.
For our particular application, b0≤1 . If all edges are deleted, then the best
previously known deterministic algorithm requires time O(mn−−√) to solve this
problem. We also present two applications of these consensus tree algorithms which
solve other problems in computational evolutionary biology."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: V.
full_name: King, V.
last_name: King
- first_name: T.
full_name: Warnow, T.
last_name: Warnow
citation:
ama: Henzinger MH, King V, Warnow T. Constructing a tree from homeomorphic subtrees,
with applications to computational evolutionary biology. Algorithmica.
1999;24:1-13. doi:10.1007/pl00009268
apa: Henzinger, M. H., King, V., & Warnow, T. (1999). Constructing a tree from
homeomorphic subtrees, with applications to computational evolutionary biology.
Algorithmica. Springer Nature. https://doi.org/10.1007/pl00009268
chicago: Henzinger, Monika H, V. King, and T. Warnow. “Constructing a Tree from
Homeomorphic Subtrees, with Applications to Computational Evolutionary Biology.”
Algorithmica. Springer Nature, 1999. https://doi.org/10.1007/pl00009268.
ieee: M. H. Henzinger, V. King, and T. Warnow, “Constructing a tree from homeomorphic
subtrees, with applications to computational evolutionary biology,” Algorithmica,
vol. 24. Springer Nature, pp. 1–13, 1999.
ista: Henzinger MH, King V, Warnow T. 1999. Constructing a tree from homeomorphic
subtrees, with applications to computational evolutionary biology. Algorithmica.
24, 1–13.
mla: Henzinger, Monika H., et al. “Constructing a Tree from Homeomorphic Subtrees,
with Applications to Computational Evolutionary Biology.” Algorithmica,
vol. 24, Springer Nature, 1999, pp. 1–13, doi:10.1007/pl00009268.
short: M.H. Henzinger, V. King, T. Warnow, Algorithmica 24 (1999) 1–13.
date_created: 2022-07-27T15:02:28Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2023-02-21T16:33:24Z
day: '01'
doi: 10.1007/pl00009268
extern: '1'
intvolume: ' 24'
keyword:
- Algorithms
- Data structures
- Evolutionary biology
- Theory of databases
language:
- iso: eng
month: '05'
oa_version: None
page: 1-13
publication: Algorithmica
publication_identifier:
eissn:
- 1432-0541
issn:
- 0178-4617
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '11927'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Constructing a tree from homeomorphic subtrees, with applications to computational
evolutionary biology
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '1999'
...
---
_id: '11687'
abstract:
- lang: eng
text: "When using traditional search engines, users have to formulate queries to
describe their information need. This paper discusses a different approach to
Web searching where the input to the search process is not a set of query terms,
but instead is the URL of a page, and the output is a set of related Web pages.
A related Web page is one that addresses the same topic as the original page.
For example, www.washingtonpost.com is a page related to www.nytimes.com, since
both are online newspapers.\r\n\r\nWe describe two algorithms to identify related
Web pages. These algorithms use only the connectivity information in the Web (i.e.,
the links between pages) and not the content of pages or usage information. We
have implemented both algorithms and measured their runtime performance. To evaluate
the effectiveness of our algorithms, we performed a user study comparing our algorithms
with Netscape's `What's Related' service (http://home.netscape.com/escapes/related/).
Our study showed that the precision at 10 for our two algorithms are 73% better
and 51% better than that of Netscape, despite the fact that Netscape uses both
content and usage pattern information in addition to connectivity information."
article_processing_charge: No
article_type: original
author:
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Dean J, Henzinger MH. Finding related pages in the world wide Web. Computer
Networks. 1999;31(11-16):1467-1479. doi:10.1016/s1389-1286(99)00022-5
apa: Dean, J., & Henzinger, M. H. (1999). Finding related pages in the world
wide Web. Computer Networks. Elsevier. https://doi.org/10.1016/s1389-1286(99)00022-5
chicago: Dean, Jeffrey, and Monika H Henzinger. “Finding Related Pages in the World
Wide Web.” Computer Networks. Elsevier, 1999. https://doi.org/10.1016/s1389-1286(99)00022-5.
ieee: J. Dean and M. H. Henzinger, “Finding related pages in the world wide Web,”
Computer Networks, vol. 31, no. 11–16. Elsevier, pp. 1467–1479, 1999.
ista: Dean J, Henzinger MH. 1999. Finding related pages in the world wide Web. Computer
Networks. 31(11–16), 1467–1479.
mla: Dean, Jeffrey, and Monika H. Henzinger. “Finding Related Pages in the World
Wide Web.” Computer Networks, vol. 31, no. 11–16, Elsevier, 1999, pp. 1467–79,
doi:10.1016/s1389-1286(99)00022-5.
short: J. Dean, M.H. Henzinger, Computer Networks 31 (1999) 1467–1479.
date_created: 2022-07-29T06:55:26Z
date_published: 1999-05-17T00:00:00Z
date_updated: 2022-09-12T09:12:21Z
day: '17'
doi: 10.1016/s1389-1286(99)00022-5
extern: '1'
intvolume: ' 31'
issue: 11-16
keyword:
- Search engines
- Related pages
- Searching paradigms
language:
- iso: eng
month: '05'
oa_version: None
page: 1467-1479
publication: Computer Networks
publication_identifier:
issn:
- 1389-1286
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Finding related pages in the world wide Web
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1999'
...
---
_id: '11688'
abstract:
- lang: eng
text: Recent research has studied how to measure the size of a search engine, in
terms of the number of pages indexed. In this paper, we consider a different measure
for search engines, namely the quality of the pages in a search engine index.
We provide a simple, effective algorithm for approximating the quality of an index
by performing a random walk on the Web, and we use this methodology to compare
the index quality of several major search engines.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Allan
full_name: Heydon, Allan
last_name: Heydon
- first_name: Michael
full_name: Mitzenmacher, Michael
last_name: Mitzenmacher
- first_name: Marc
full_name: Najork, Marc
last_name: Najork
citation:
ama: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. Measuring index quality using
random walks on the web. Computer Networks. 1999;31(11-16):1291-1303. doi:10.1016/s1389-1286(99)00016-x
apa: Henzinger, M. H., Heydon, A., Mitzenmacher, M., & Najork, M. (1999). Measuring
index quality using random walks on the web. Computer Networks. Elsevier.
https://doi.org/10.1016/s1389-1286(99)00016-x
chicago: Henzinger, Monika H, Allan Heydon, Michael Mitzenmacher, and Marc Najork.
“Measuring Index Quality Using Random Walks on the Web.” Computer Networks.
Elsevier, 1999. https://doi.org/10.1016/s1389-1286(99)00016-x.
ieee: M. H. Henzinger, A. Heydon, M. Mitzenmacher, and M. Najork, “Measuring index
quality using random walks on the web,” Computer Networks, vol. 31, no.
11–16. Elsevier, pp. 1291–1303, 1999.
ista: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. 1999. Measuring index quality
using random walks on the web. Computer Networks. 31(11–16), 1291–1303.
mla: Henzinger, Monika H., et al. “Measuring Index Quality Using Random Walks on
the Web.” Computer Networks, vol. 31, no. 11–16, Elsevier, 1999, pp. 1291–303,
doi:10.1016/s1389-1286(99)00016-x.
short: M.H. Henzinger, A. Heydon, M. Mitzenmacher, M. Najork, Computer Networks
31 (1999) 1291–1303.
date_created: 2022-07-29T07:00:28Z
date_published: 1999-05-17T00:00:00Z
date_updated: 2022-09-12T09:13:55Z
day: '17'
doi: 10.1016/s1389-1286(99)00016-x
extern: '1'
intvolume: ' 31'
issue: 11-16
keyword:
- Search engines
- Index quality
- Random walks
- PageRank
language:
- iso: eng
month: '05'
oa_version: None
page: 1291-1303
publication: Computer Networks
publication_identifier:
issn:
- 1389-1286
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Measuring index quality using random walks on the web
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1999'
...
---
_id: '11691'
abstract:
- lang: eng
text: In this paper we consider the online ftp problem. The goal is to service a
sequence of file transfer requests given bandwidth constraints of the underlying
communication network. The main result of the paper is a technique that leads
to algorithms that optimize several natural metrics, such as max-stretch, total
flow time, max flow time, and total completion time. In particular, we show how
to achieve optimum total flow time and optimum max-stretch if we increase the
capacity of the underlying network by a logarithmic factor. We show that the resource
augmentation is necessary by proving polynomial lower bounds on the max-stretch
and total flow time for the case where online and offline algorithms are using
same-capacity edges. Moreover, we also give polylogarithmic lower bounds on the
resource augmentation factor necessary in order to keep the total flow time and
max-stretch within a constant factor of optimum.
article_processing_charge: No
author:
- first_name: Ashish
full_name: Goel, Ashish
last_name: Goel
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Serge
full_name: Plotkin, Serge
last_name: Plotkin
- first_name: Eva
full_name: Tardos, Eva
last_name: Tardos
citation:
ama: 'Goel A, Henzinger MH, Plotkin S, Tardos E. Scheduling data transfers in a
network and the set scheduling problem. In: Proceedings of the 31st Annual
ACM Symposium on Theory of Computing. Association for Computing Machinery;
1999:189-197. doi:10.1145/301250.301300'
apa: 'Goel, A., Henzinger, M. H., Plotkin, S., & Tardos, E. (1999). Scheduling
data transfers in a network and the set scheduling problem. In Proceedings
of the 31st annual ACM symposium on Theory of computing (pp. 189–197). Atlanta,
GA, United States: Association for Computing Machinery. https://doi.org/10.1145/301250.301300'
chicago: Goel, Ashish, Monika H Henzinger, Serge Plotkin, and Eva Tardos. “Scheduling
Data Transfers in a Network and the Set Scheduling Problem.” In Proceedings
of the 31st Annual ACM Symposium on Theory of Computing, 189–97. Association
for Computing Machinery, 1999. https://doi.org/10.1145/301250.301300.
ieee: A. Goel, M. H. Henzinger, S. Plotkin, and E. Tardos, “Scheduling data transfers
in a network and the set scheduling problem,” in Proceedings of the 31st annual
ACM symposium on Theory of computing, Atlanta, GA, United States, 1999, pp.
189–197.
ista: 'Goel A, Henzinger MH, Plotkin S, Tardos E. 1999. Scheduling data transfers
in a network and the set scheduling problem. Proceedings of the 31st annual ACM
symposium on Theory of computing. STOC: Symposium on Theory of Computing, 189–197.'
mla: Goel, Ashish, et al. “Scheduling Data Transfers in a Network and the Set Scheduling
Problem.” Proceedings of the 31st Annual ACM Symposium on Theory of Computing,
Association for Computing Machinery, 1999, pp. 189–97, doi:10.1145/301250.301300.
short: A. Goel, M.H. Henzinger, S. Plotkin, E. Tardos, in:, Proceedings of the 31st
Annual ACM Symposium on Theory of Computing, Association for Computing Machinery,
1999, pp. 189–197.
conference:
end_date: 1999-05-04
location: ' Atlanta, GA, United States'
name: 'STOC: Symposium on Theory of Computing'
start_date: 1999-05-01
date_created: 2022-07-29T07:43:00Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2023-02-09T11:47:09Z
day: '01'
doi: 10.1145/301250.301300
extern: '1'
keyword:
- Scheduling
- Flow time
language:
- iso: eng
month: '05'
oa_version: None
page: 189-197
publication: Proceedings of the 31st annual ACM symposium on Theory of computing
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scheduling data transfers in a network and the set scheduling problem
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1999'
...
---
_id: '11769'
abstract:
- lang: eng
text: "This paper solves a longstanding open problem in fully dynamic algorithms:
We present the first fully dynamic algorithms that maintain connectivity, bipartiteness,
and approximate minimum spanning trees in polylogarithmic time per edge insertion
or deletion. The algorithms are designed using a new dynamic technique that combines
a novel graph decomposition with randomization. They are Las-Vegas type randomized
algorithms which use simple data structures and have a small constant factor.\r\nLet
n denote the number of nodes in the graph. For a sequence of Ω(m0) operations,
where m0 is the number of edges in the initial graph, the expected time for p
updates is O(p log3 n) (througout the paper the logarithms are based 2) for connectivity
and bipartiteness. The worst-case time for one query is O(log n/log log n). For
the k-edge witness problem (“Does the removal of k given edges disconnect the
graph?”) the expected time for p updates is O(p log3 n) and the expected time
for q queries is O(qk log3 n). Given a graph with k different weights, the minimum
spanning tree can be maintained during a sequence of p updates in expected time
O(pk log3 n). This implies an algorithm to maintain a 1 + ε-approximation of the
minimum spanning tree in expected time O((p log3 n logU)/ε) for p updates, where
the weights of the edges are between 1 and U."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Valerie
full_name: King, Valerie
last_name: King
citation:
ama: Henzinger MH, King V. Randomized fully dynamic graph algorithms with polylogarithmic
time per operation. Journal of the ACM. 1999;46(4):502-516. doi:10.1145/320211.320215
apa: Henzinger, M. H., & King, V. (1999). Randomized fully dynamic graph algorithms
with polylogarithmic time per operation. Journal of the ACM. Association
for Computing Machinery. https://doi.org/10.1145/320211.320215
chicago: Henzinger, Monika H, and Valerie King. “Randomized Fully Dynamic Graph
Algorithms with Polylogarithmic Time per Operation.” Journal of the ACM.
Association for Computing Machinery, 1999. https://doi.org/10.1145/320211.320215.
ieee: M. H. Henzinger and V. King, “Randomized fully dynamic graph algorithms with
polylogarithmic time per operation,” Journal of the ACM, vol. 46, no. 4.
Association for Computing Machinery, pp. 502–516, 1999.
ista: Henzinger MH, King V. 1999. Randomized fully dynamic graph algorithms with
polylogarithmic time per operation. Journal of the ACM. 46(4), 502–516.
mla: Henzinger, Monika H., and Valerie King. “Randomized Fully Dynamic Graph Algorithms
with Polylogarithmic Time per Operation.” Journal of the ACM, vol. 46,
no. 4, Association for Computing Machinery, 1999, pp. 502–16, doi:10.1145/320211.320215.
short: M.H. Henzinger, V. King, Journal of the ACM 46 (1999) 502–516.
date_created: 2022-08-08T12:50:25Z
date_published: 1999-07-01T00:00:00Z
date_updated: 2022-09-12T10:50:08Z
day: '01'
doi: 10.1145/320211.320215
extern: '1'
intvolume: ' 46'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
page: 502-516
publication: Journal of the ACM
publication_identifier:
eissn:
- 1557-735X
issn:
- 0004-5411
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Randomized fully dynamic graph algorithms with polylogarithmic time per operation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '1999'
...
---
_id: '8526'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. An extension of the Artin-Mazur theorem. The Annals of Mathematics.
1999;150(2):729-741. doi:10.2307/121093
apa: Kaloshin, V. (1999). An extension of the Artin-Mazur theorem. The Annals
of Mathematics. JSTOR. https://doi.org/10.2307/121093
chicago: Kaloshin, Vadim. “An Extension of the Artin-Mazur Theorem.” The Annals
of Mathematics. JSTOR, 1999. https://doi.org/10.2307/121093.
ieee: V. Kaloshin, “An extension of the Artin-Mazur theorem,” The Annals of Mathematics,
vol. 150, no. 2. JSTOR, pp. 729–741, 1999.
ista: Kaloshin V. 1999. An extension of the Artin-Mazur theorem. The Annals of Mathematics.
150(2), 729–741.
mla: Kaloshin, Vadim. “An Extension of the Artin-Mazur Theorem.” The Annals of
Mathematics, vol. 150, no. 2, JSTOR, 1999, pp. 729–41, doi:10.2307/121093.
short: V. Kaloshin, The Annals of Mathematics 150 (1999) 729–741.
date_created: 2020-09-18T10:50:28Z
date_published: 1999-09-01T00:00:00Z
date_updated: 2021-01-12T08:19:53Z
day: '01'
doi: 10.2307/121093
extern: '1'
intvolume: ' 150'
issue: '2'
keyword:
- Statistics
- Probability and Uncertainty
- Statistics and Probability
language:
- iso: eng
month: '09'
oa_version: None
page: 729-741
publication: The Annals of Mathematics
publication_identifier:
issn:
- 0003-486X
publication_status: published
publisher: JSTOR
quality_controlled: '1'
status: public
title: An extension of the Artin-Mazur theorem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 150
year: '1999'
...