---
_id: '2732'
abstract:
- lang: eng
text: 'We consider a quantum particle moving in a harmonic exterior potential and
linearly coupled to a heat bath of quantum oscillators. Caldeira and Leggett derived
the Fokker Planck equation with friction for the Wigner distribution of the particle
in the large-temperature limit: however, their (nonrigorous) derivation was not
free of criticism, especially since the limiting equation is not of Lindblad form.
In this paper we recover the correct form of their result in a rigorous way. We
also point out that the source of the diffusion is physically restrictive under
this scaling. We investigate the model at a fixed temperature and in the large-time
limit, where the origin of the diffusion is a cumulative effect of many resonant
collisions. We obtain a heat equation with a friction term for the radial process
in phase space and we prove the Einstein relation in this case.'
acknowledgement: The authors are indebted to H. Spohn for discussions. F.C. and L.E.
were partially supported by the Erwin Schrödinger Institute in Vienna (Austria)
during their visit, and they thank this institution for its hospitality. This work
was supported by the TMR-Network ``Asymptotic Methods in Kinetic Theory'' number
ERB FMBX CT97 0157 (F.C., F.F., and P.A.M.) and by NSF Grant DMS-9970323 (L.E.).
article_processing_charge: No
article_type: original
author:
- first_name: François
full_name: Castella, François
last_name: Castella
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Florian
full_name: Frommlet, Florian
last_name: Frommlet
- first_name: Peter
full_name: Markowich, Peter
last_name: Markowich
citation:
ama: Castella F, Erdös L, Frommlet F, Markowich P. Fokker-Planck equations as scaling
limits of reversible quantum systems. Journal of Statistical Physics. 2000;100(3-4):543-601.
doi:10.1023/A:1018667323830
apa: Castella, F., Erdös, L., Frommlet, F., & Markowich, P. (2000). Fokker-Planck
equations as scaling limits of reversible quantum systems. Journal of Statistical
Physics. Springer. https://doi.org/10.1023/A:1018667323830
chicago: Castella, François, László Erdös, Florian Frommlet, and Peter Markowich.
“Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal
of Statistical Physics. Springer, 2000. https://doi.org/10.1023/A:1018667323830.
ieee: F. Castella, L. Erdös, F. Frommlet, and P. Markowich, “Fokker-Planck equations
as scaling limits of reversible quantum systems,” Journal of Statistical Physics,
vol. 100, no. 3–4. Springer, pp. 543–601, 2000.
ista: Castella F, Erdös L, Frommlet F, Markowich P. 2000. Fokker-Planck equations
as scaling limits of reversible quantum systems. Journal of Statistical Physics.
100(3–4), 543–601.
mla: Castella, François, et al. “Fokker-Planck Equations as Scaling Limits of Reversible
Quantum Systems.” Journal of Statistical Physics, vol. 100, no. 3–4, Springer,
2000, pp. 543–601, doi:10.1023/A:1018667323830.
short: F. Castella, L. Erdös, F. Frommlet, P. Markowich, Journal of Statistical
Physics 100 (2000) 543–601.
date_created: 2018-12-11T11:59:18Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T09:02:11Z
day: '01'
doi: 10.1023/A:1018667323830
extern: '1'
intvolume: ' 100'
issue: 3-4
language:
- iso: eng
month: '01'
oa_version: None
page: 543 - 601
publication: Journal of Statistical Physics
publication_identifier:
issn:
- 0022-4715
publication_status: published
publisher: Springer
publist_id: '4160'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fokker-Planck equations as scaling limits of reversible quantum systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 100
year: '2000'
...
---
_id: '2733'
abstract:
- lang: eng
text: The Li-Yau semiclassical lower bound for the sum of the first N eigenvalues
of the Dirichlet–Laplacian is extended to Dirichlet–Laplacians with constant magnetic
fields. Our method involves a new diamagnetic inequality for constant magnetic
fields.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Michael
full_name: Loss, Michael
last_name: Loss
- first_name: Vitali
full_name: Vougalter, Vitali
last_name: Vougalter
citation:
ama: Erdös L, Loss M, Vougalter V. Diamagnetic behavior of sums Dirichlet eigenvalues.
Annales de l’Institut Fourier. 2000;50(3):891-907. doi:10.5802/aif.1777
apa: Erdös, L., Loss, M., & Vougalter, V. (2000). Diamagnetic behavior of sums
Dirichlet eigenvalues. Annales de l’Institut Fourier. Association des Annales
de l’Institut Fourier. https://doi.org/10.5802/aif.1777
chicago: Erdös, László, Michael Loss, and Vitali Vougalter. “Diamagnetic Behavior
of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier. Association
des Annales de l’Institut Fourier, 2000. https://doi.org/10.5802/aif.1777.
ieee: L. Erdös, M. Loss, and V. Vougalter, “Diamagnetic behavior of sums Dirichlet
eigenvalues,” Annales de l’Institut Fourier, vol. 50, no. 3. Association
des Annales de l’Institut Fourier, pp. 891–907, 2000.
ista: Erdös L, Loss M, Vougalter V. 2000. Diamagnetic behavior of sums Dirichlet
eigenvalues. Annales de l’Institut Fourier. 50(3), 891–907.
mla: Erdös, László, et al. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.”
Annales de l’Institut Fourier, vol. 50, no. 3, Association des Annales
de l’Institut Fourier, 2000, pp. 891–907, doi:10.5802/aif.1777.
short: L. Erdös, M. Loss, V. Vougalter, Annales de l’Institut Fourier 50 (2000)
891–907.
date_created: 2018-12-11T11:59:19Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T08:56:17Z
day: '01'
doi: 10.5802/aif.1777
extern: '1'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 891 - 907
publication: Annales de l'Institut Fourier
publication_identifier:
issn:
- 0373-0956
publication_status: published
publisher: Association des Annales de l'Institut Fourier
publist_id: '4159'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diamagnetic behavior of sums Dirichlet eigenvalues
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '2000'
...
---
_id: '3149'
abstract:
- lang: eng
text: The prohormone convertases (PCs) are an evolutionarily ancient group of proteases
required for the maturation of neuropeptide and peptide hormone precursors. In
Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado),
is required for normal hatching behavior, and immunoblotting data indicate that
flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires
7B2, a helper protein for productive maturation, we searched the fly data base
for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone
encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were
subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and
rat 7B2 were used as controls. Although active mPC2 was detected in medium in
the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon
coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was
synthesized but not secreted from HEK-293 cells. However, when dPC2 and either
d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive
dPC2 was secreted into the medium, coincident with the appearance of PC2 activity.
Expression and secretion of dPC2 enzyme activity thus appears to require insect
cell-specific posttranslational processing events. The significant differences
in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required
for secretion of dPC2 and zymogen conversion occurring intracellularly in the
case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific
requirements for maturation and secretion that can be met only in insect cells.
acknowledgement: This work was supported by National Institutes of Health Grants DK49703
(to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section
1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory
and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans
PC2 expression vector, and Joelle Finley for assistance with cell culture.
article_processing_charge: No
article_type: original
author:
- first_name: Jae
full_name: Hwang, Jae
last_name: Hwang
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
- first_name: Paul
full_name: Taghert, Paul
last_name: Taghert
- first_name: Iris
full_name: Lindberg, Iris
last_name: Lindberg
citation:
ama: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila
melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing
and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893.
doi:10.1074/jbc.M000032200 '
apa: 'Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000).
Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 '
chicago: 'Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg.
“Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect
Cell Specific Processing and Secretion.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .'
ieee: 'J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion,” Journal of Biological Chemistry, vol. 275, no.
23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893,
2000.'
ista: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.'
mla: 'Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase
2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological
Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular
Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .'
short: J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological
Chemistry 275 (2000) 17886–17893.
date_created: 2018-12-11T12:01:40Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T08:47:13Z
day: '09'
doi: '10.1074/jbc.M000032200 '
extern: '1'
external_id:
pmid:
- '10749852'
intvolume: ' 275'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 17886 - 17893
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '3546'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 275
year: '2000'
...
---
_id: '11126'
abstract:
- lang: eng
text: Nuclear import of the two uracil-rich small nuclear ribonucleoprotein (U snRNP)
components U1A and U2B′′ is mediated by unusually long and complex nuclear localization
signals (NLSs). Here we investigate nuclear import of U1A and U2B′′ in vitro and
demonstrate that it occurs by an active, saturable process. Several lines of evidence
suggest that import of the two proteins occurs by an import mechanism different
to those characterized previously. No cross competition is seen with a variety
of previously studied NLSs. In contrast to import mediated by members of the importin-β
family of nucleocytoplasmic transport receptors, U1A/U2B′′ import is not inhibited
by either nonhydrolyzable guanosine triphosphate (GTP) analogues or by a mutant
of the GTPase Ran that is incapable of GTP hydrolysis. Adenosine triphosphate
is capable of supporting U1A and U2B′′ import, whereas neither nonhydrolyzable
adenosine triphosphate analogues nor GTP can do so. U1A and U2B′′ import in vitro
does not require the addition of soluble cytosolic proteins, but a factor or factors
required for U1A and U2B′′ import remains tightly associated with the nuclear
fraction of conventionally permeabilized cells. This activity can be solubilized
in the presence of elevated MgCl2. These data suggest that U1A and U2B′′ import
into the nucleus occurs by a hitherto uncharacterized mechanism.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Iain W.
full_name: Mattaj, Iain W.
last_name: Mattaj
citation:
ama: Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear
import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology.
2000;148(2):293-304. doi:10.1083/jcb.148.2.293
apa: Hetzer, M., & Mattaj, I. W. (2000). An Atp-dependent, Ran-independent mechanism
for nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell
Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.148.2.293
chicago: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent
Mechanism for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” Journal
of Cell Biology. Rockefeller University Press, 2000. https://doi.org/10.1083/jcb.148.2.293.
ieee: M. Hetzer and I. W. Mattaj, “An Atp-dependent, Ran-independent mechanism for
nuclear import of the U1a and U2b′′ spliceosome proteins,” Journal of Cell
Biology, vol. 148, no. 2. Rockefeller University Press, pp. 293–304, 2000.
ista: Hetzer M, Mattaj IW. 2000. An Atp-dependent, Ran-independent mechanism for
nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology.
148(2), 293–304.
mla: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent Mechanism
for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” Journal of Cell
Biology, vol. 148, no. 2, Rockefeller University Press, 2000, pp. 293–304,
doi:10.1083/jcb.148.2.293.
short: M. Hetzer, I.W. Mattaj, Journal of Cell Biology 148 (2000) 293–304.
date_created: 2022-04-07T07:57:49Z
date_published: 2000-01-24T00:00:00Z
date_updated: 2022-07-18T08:58:29Z
day: '24'
doi: 10.1083/jcb.148.2.293
extern: '1'
external_id:
pmid:
- '10648562'
intvolume: ' 148'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 293-304
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and
U2b′′ spliceosome proteins
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 148
year: '2000'
...
---
_id: '11127'
abstract:
- lang: eng
text: Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited
by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE)
vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran
GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for
Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion
can be complemented by the addition of Ran loaded with either GTP or GDP but not
with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus,
generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the
extensive membrane fusion events that lead to NE formation.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Daniel
full_name: Bilbao-Cortés, Daniel
last_name: Bilbao-Cortés
- first_name: Tobias C
full_name: Walther, Tobias C
last_name: Walther
- first_name: Oliver J
full_name: Gruss, Oliver J
last_name: Gruss
- first_name: Iain W
full_name: Mattaj, Iain W
last_name: Mattaj
citation:
ama: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024.
doi:10.1016/s1097-2765(00)80266-x
apa: Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., & Mattaj,
I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly.
Molecular Cell. Elsevier. https://doi.org/10.1016/s1097-2765(00)80266-x
chicago: Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss,
and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.”
Molecular Cell. Elsevier, 2000. https://doi.org/10.1016/s1097-2765(00)80266-x.
ieee: M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj,
“GTP hydrolysis by Ran is required for nuclear envelope assembly,” Molecular
Cell, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000.
ista: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.
mla: Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope
Assembly.” Molecular Cell, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24,
doi:10.1016/s1097-2765(00)80266-x.
short: M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular
Cell 5 (2000) 1013–1024.
date_created: 2022-04-07T07:57:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-07-18T08:58:31Z
day: '01'
doi: 10.1016/s1097-2765(00)80266-x
extern: '1'
external_id:
pmid:
- '10911995'
intvolume: ' 5'
issue: '6'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S1097-2765(00)80266-X
month: '06'
oa: 1
oa_version: Published Version
page: 1013-1024
pmid: 1
publication: Molecular Cell
publication_identifier:
issn:
- 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GTP hydrolysis by Ran is required for nuclear envelope assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 5
year: '2000'
...
---
_id: '11683'
abstract:
- lang: eng
text: The vertex connectivity κ of a graph is the smallest number of vertices whose
deletion separates the graph or makes it trivial. We present the fastest known
deterministic algorithm for finding the vertex connectivity and a corresponding
separator. The time for a digraph having n vertices and m edges is O(min{κ3 +
n, κn}m); for an undirected graph the term m can be replaced by κn. A randomized
algorithm finds κ with error probability 1/2 in time O(nm). If the vertices have
nonnegative weights the weighted vertex connectivity is found in time O(κ1nmlog(n2/m))
where κ1 ≤ m/n is the unweighted vertex connectivity or in expected time O(nmlog(n2/m))
with error probability 1/2. The main algorithm combines two previous vertex connectivity
algorithms and a generalization of the preflow-push algorithm of Hao and Orlin
(1994, J. Algorithms17, 424–446) that computes edge connectivity.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Harold N.
full_name: Gabow, Harold N.
last_name: Gabow
citation:
ama: 'Henzinger MH, Rao S, Gabow HN. Computing vertex connectivity: New bounds from
old techniques. Journal of Algorithms. 2000;34(2):222-250. doi:10.1006/jagm.1999.1055'
apa: 'Henzinger, M. H., Rao, S., & Gabow, H. N. (2000). Computing vertex connectivity:
New bounds from old techniques. Journal of Algorithms. Elsevier. https://doi.org/10.1006/jagm.1999.1055'
chicago: 'Henzinger, Monika H, Satish Rao, and Harold N. Gabow. “Computing Vertex
Connectivity: New Bounds from Old Techniques.” Journal of Algorithms. Elsevier,
2000. https://doi.org/10.1006/jagm.1999.1055.'
ieee: 'M. H. Henzinger, S. Rao, and H. N. Gabow, “Computing vertex connectivity:
New bounds from old techniques,” Journal of Algorithms, vol. 34, no. 2.
Elsevier, pp. 222–250, 2000.'
ista: 'Henzinger MH, Rao S, Gabow HN. 2000. Computing vertex connectivity: New bounds
from old techniques. Journal of Algorithms. 34(2), 222–250.'
mla: 'Henzinger, Monika H., et al. “Computing Vertex Connectivity: New Bounds from
Old Techniques.” Journal of Algorithms, vol. 34, no. 2, Elsevier, 2000,
pp. 222–50, doi:10.1006/jagm.1999.1055.'
short: M.H. Henzinger, S. Rao, H.N. Gabow, Journal of Algorithms 34 (2000) 222–250.
date_created: 2022-07-28T08:56:10Z
date_published: 2000-02-01T00:00:00Z
date_updated: 2022-09-12T09:06:48Z
day: '01'
doi: 10.1006/jagm.1999.1055
extern: '1'
intvolume: ' 34'
issue: '2'
keyword:
- Computational Theory and Mathematics
- Computational Mathematics
- Control and Optimization
language:
- iso: eng
month: '02'
oa_version: None
page: 222-250
publication: Journal of Algorithms
publication_identifier:
issn:
- 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Computing vertex connectivity: New bounds from old techniques'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2000'
...
---
_id: '11685'
abstract:
- lang: eng
text: We consider the problem of sampling URLs uniformly at random from the Web.
A tool for sampling URLs uniformly can be used to estimate various properties
of Web pages, such as the fraction of pages in various Internet domains or written
in various languages. Moreover, uniform URL sampling can be used to determine
the sizes of various search engines relative to the entire Web. In this paper,
we consider sampling approaches based on random walks of the Web graph. In particular,
we suggest ways of improving sampling based on random walks to make the samples
closer to uniform. We suggest a natural test bed based on random graphs for testing
the effectiveness of our procedures. We then use our sampling approach to estimate
the distribution of pages over various Internet domains and to estimate the coverage
of various search engine indexes.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Allan
full_name: Heydon, Allan
last_name: Heydon
- first_name: Michael
full_name: Mitzenmacher, Michael
last_name: Mitzenmacher
- first_name: Marc
full_name: Najork, Marc
last_name: Najork
citation:
ama: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. On near-uniform URL sampling.
Computer Networks. 2000;33(1-6):295-308. doi:10.1016/s1389-1286(00)00055-4
apa: Henzinger, M. H., Heydon, A., Mitzenmacher, M., & Najork, M. (2000). On
near-uniform URL sampling. Computer Networks. Elsevier. https://doi.org/10.1016/s1389-1286(00)00055-4
chicago: Henzinger, Monika H, Allan Heydon, Michael Mitzenmacher, and Marc Najork.
“On Near-Uniform URL Sampling.” Computer Networks. Elsevier, 2000. https://doi.org/10.1016/s1389-1286(00)00055-4.
ieee: M. H. Henzinger, A. Heydon, M. Mitzenmacher, and M. Najork, “On near-uniform
URL sampling,” Computer Networks, vol. 33, no. 1–6. Elsevier, pp. 295–308,
2000.
ista: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. 2000. On near-uniform URL
sampling. Computer Networks. 33(1–6), 295–308.
mla: Henzinger, Monika H., et al. “On Near-Uniform URL Sampling.” Computer Networks,
vol. 33, no. 1–6, Elsevier, 2000, pp. 295–308, doi:10.1016/s1389-1286(00)00055-4.
short: M.H. Henzinger, A. Heydon, M. Mitzenmacher, M. Najork, Computer Networks
33 (2000) 295–308.
date_created: 2022-07-28T15:11:53Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-09-12T09:09:13Z
day: '01'
doi: 10.1016/s1389-1286(00)00055-4
extern: '1'
intvolume: ' 33'
issue: 1-6
keyword:
- URL sampling
- Random walks
- Internet domain distribution
- Search engine size
language:
- iso: eng
month: '06'
oa_version: None
page: 295-308
publication: Computer Networks
publication_identifier:
issn:
- 1389-1286
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On near-uniform URL sampling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2000'
...
---
_id: '11694'
abstract:
- lang: eng
text: We consider exploration problems where a robot has to construct a complete
map of an unknown environment. We assume that the environment is modeled by a
directed, strongly connected graph. The robot's task is to visit all nodes and
edges of the graph using the minimum number R of edge traversals. Deng and Papadimitriou
[Proceedings of the 31st Symposium on the Foundations of Computer Science, 1990,
pp. 356-361] showed an upper bound for R ofd O(d)m and Koutsoupias (reported by
Deng and Papadimitriou) gave a lower bound of Ω≠(d2m), where m is the number of
edges in the graph and d is the minimum number of edges that have to be added
to make the graph Eulerian. We give the 1rst subexponential algorithm for this
exploration problem, which achieves an upper bound of dO(logd)m. We also show
a matching lower bound of d≠(logd)m for our algorithm. Additionally, we give lower
bounds of 2≠(d)m, respectively, d≠(logd)m for various other natural exploration
algorithms.
acknowledgement: We thank Prabhakar Raghavan for bringing to our attention the literature
on the s-t connectivity problem. We also thank an anonymous referee for many helpful
comments which improved the presentation of the paper.
article_processing_charge: No
article_type: original
author:
- first_name: Susanne
full_name: Albers, Susanne
last_name: Albers
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Albers S, Henzinger MH. Exploring unknown environments. SIAM Journal on
Computing. 2000;29(4):1164-1188. doi:10.1137/s009753979732428x
apa: 'Albers, S., & Henzinger, M. H. (2000). Exploring unknown environments.
SIAM Journal on Computing. El Paso, TX, United States: Society for Industrial
and Applied Mathematics. https://doi.org/10.1137/s009753979732428x'
chicago: Albers, Susanne, and Monika H Henzinger. “Exploring Unknown Environments.”
SIAM Journal on Computing. Society for Industrial and Applied Mathematics,
2000. https://doi.org/10.1137/s009753979732428x.
ieee: S. Albers and M. H. Henzinger, “Exploring unknown environments,” SIAM Journal
on Computing, vol. 29, no. 4. Society for Industrial and Applied Mathematics,
pp. 1164–1188, 2000.
ista: Albers S, Henzinger MH. 2000. Exploring unknown environments. SIAM Journal
on Computing. 29(4), 1164–1188.
mla: Albers, Susanne, and Monika H. Henzinger. “Exploring Unknown Environments.”
SIAM Journal on Computing, vol. 29, no. 4, Society for Industrial and Applied
Mathematics, 2000, pp. 1164–88, doi:10.1137/s009753979732428x.
short: S. Albers, M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1164–1188.
conference:
end_date: 1997-05-06
location: El Paso, TX, United States
name: 'STOC97: 29th Annual Symposium on Theory of Computing'
start_date: 1997-05-04
date_created: 2022-07-29T09:04:36Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-02-17T14:41:36Z
day: '01'
doi: 10.1137/s009753979732428x
extern: '1'
intvolume: ' 29'
issue: '4'
keyword:
- directed graph
- exploration algorithm
language:
- iso: eng
month: '07'
oa_version: None
page: 1164-1188
publication: SIAM Journal on Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring unknown environments
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '11770'
abstract:
- lang: eng
text: 'We compare several algorithms for identifying mirrored hosts on the World
Wide Web. The algorithms operate on the basis of URL strings and linkage data:
the type of information about Web pages easily available from Web proxies and
crawlers. Identification of mirrored hosts can improve Web-based information retrieval
in several ways: first, by identifying mirrored hosts, search engines can avoid
storing and returning duplicate documents. Second, several new information retrieval
techniques for the Web make inferences based on the explicit links among hypertext
documents—mirroring perturbs their graph model and degrades performance. Third,
mirroring information can be used to redirect users to alternate mirror sites
to compensate for various failures, and can thus improve the performance of Web
browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting
mirrored host pairs (that is, algorithms that are based on page attributes such
as URL, IP address, and hyperlinks between pages, and not on the page content)
on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity
information. Our best approach is one which combines five algorithms and achieved
a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.'
article_processing_charge: No
article_type: original
author:
- first_name: Krishna
full_name: Bharat, Krishna
last_name: Bharat
- first_name: Andrei
full_name: Broder, Andrei
last_name: Broder
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find
mirrored hosts on the WWW. Journal of the American Society for Information
Science. 2000;51(12):1114-1122. doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
apa: Bharat, K., Broder, A., Dean, J., & Henzinger, M. H. (2000). A comparison
of techniques to find mirrored hosts on the WWW. Journal of the American Society
for Information Science. Wiley. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
chicago: Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A
Comparison of Techniques to Find Mirrored Hosts on the WWW.” Journal of the
American Society for Information Science. Wiley, 2000. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
ieee: K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques
to find mirrored hosts on the WWW,” Journal of the American Society for Information
Science, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.
ista: Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques
to find mirrored hosts on the WWW. Journal of the American Society for Information
Science. 51(12), 1114–1122.
mla: Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts
on the WWW.” Journal of the American Society for Information Science, vol.
51, no. 12, Wiley, 2000, pp. 1114–22, doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
short: K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society
for Information Science 51 (2000) 1114–1122.
date_created: 2022-08-08T12:57:37Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-02-10T08:27:19Z
day: '01'
doi: 10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
extern: '1'
intvolume: ' 51'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
month: '10'
oa: 1
oa_version: Published Version
page: 1114-1122
publication: Journal of the American Society for Information Science
publication_identifier:
issn:
- 0002-8231
- 1097-4571
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of techniques to find mirrored hosts on the WWW
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2000'
...
---
_id: '11802'
abstract:
- lang: eng
text: In this paper we survey algorithmic aspects of Web information retrieval.
As an example, we discuss ranking of search engine results using connectivity
analysis.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Web information retrieval - an algorithmic perspective. In:
8th Annual European Symposium on Algorithms. Vol 1879. Springer Nature;
2000:1–8. doi:10.1007/3-540-45253-2_1'
apa: 'Henzinger, M. H. (2000). Web information retrieval - an algorithmic perspective.
In 8th Annual European Symposium on Algorithms (Vol. 1879, pp. 1–8). Saarbrücken,
Germany: Springer Nature. https://doi.org/10.1007/3-540-45253-2_1'
chicago: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
In 8th Annual European Symposium on Algorithms, 1879:1–8. Springer Nature,
2000. https://doi.org/10.1007/3-540-45253-2_1.
ieee: M. H. Henzinger, “Web information retrieval - an algorithmic perspective,”
in 8th Annual European Symposium on Algorithms, Saarbrücken, Germany, 2000,
vol. 1879, pp. 1–8.
ista: 'Henzinger MH. 2000. Web information retrieval - an algorithmic perspective.
8th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms,
LNCS, vol. 1879, 1–8.'
mla: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
8th Annual European Symposium on Algorithms, vol. 1879, Springer Nature,
2000, pp. 1–8, doi:10.1007/3-540-45253-2_1.
short: M.H. Henzinger, in:, 8th Annual European Symposium on Algorithms, Springer
Nature, 2000, pp. 1–8.
conference:
end_date: 2000-09-08
location: Saarbrücken, Germany
name: 'ESA: European Symposium on Algorithms'
start_date: 2000-09-05
date_created: 2022-08-11T13:25:07Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-02-13T12:08:21Z
day: '01'
doi: 10.1007/3-540-45253-2_1
extern: '1'
intvolume: ' 1879'
language:
- iso: eng
month: '09'
oa_version: None
page: 1–8
publication: 8th Annual European Symposium on Algorithms
publication_identifier:
eisbn:
- '9783540452539'
eissn:
- 1611-3349
isbn:
- '9783540410041'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Web information retrieval - an algorithmic perspective
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1879
year: '2000'
...
---
_id: '11893'
abstract:
- lang: eng
text: "We present fully dynamic algorithms for maintaining the biconnected components
in general and plane graphs.\r\n\r\nA fully dynamic algorithm maintains a graph
during a sequence of insertions and deletions of edges or isolated vertices. Let
m be the number of edges and n be the number of vertices in a graph. The time
per operation of the best deterministic algorithms is \U0001D442(\U0001D45B√)
in general graphs and O(log n) in plane graphs for fully dynamic connectivity
and O(min m2/3 ,n}) in general graphs and \U0001D442(\U0001D45B√) in plane graphs
for fully dynamic biconnectivity. We improve the later running times to \U0001D442(\U0001D45Alog\U0001D45B‾‾‾‾‾‾‾√)
in general graphs and O(log 2n ) in plane graphs. Our algorithm for general graphscan
also find the biconnected components of all vertices in time O(n)."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Henzinger MH. Improved data structures for fully dynamic biconnectivity. SIAM
Journal on Computing. 2000;29(6):1761-1815. doi:10.1137/s0097539794263907
apa: Henzinger, M. H. (2000). Improved data structures for fully dynamic biconnectivity.
SIAM Journal on Computing. Society for Industrial & Applied Mathematics.
https://doi.org/10.1137/s0097539794263907
chicago: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
SIAM Journal on Computing. Society for Industrial & Applied Mathematics,
2000. https://doi.org/10.1137/s0097539794263907.
ieee: M. H. Henzinger, “Improved data structures for fully dynamic biconnectivity,”
SIAM Journal on Computing, vol. 29, no. 6. Society for Industrial &
Applied Mathematics, pp. 1761–1815, 2000.
ista: Henzinger MH. 2000. Improved data structures for fully dynamic biconnectivity.
SIAM Journal on Computing. 29(6), 1761–1815.
mla: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
SIAM Journal on Computing, vol. 29, no. 6, Society for Industrial &
Applied Mathematics, 2000, pp. 1761–815, doi:10.1137/s0097539794263907.
short: M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1761–1815.
date_created: 2022-08-17T08:45:41Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-02-17T14:39:47Z
day: '01'
doi: 10.1137/s0097539794263907
extern: '1'
intvolume: ' 29'
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 1761-1815
publication: SIAM Journal on Computing
publication_identifier:
eissn:
- 1095-7111
issn:
- 0097-5397
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved data structures for fully dynamic biconnectivity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '8526'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Kaloshin V. An extension of the Artin-Mazur theorem. The Annals of Mathematics.
1999;150(2):729-741. doi:10.2307/121093
apa: Kaloshin, V. (1999). An extension of the Artin-Mazur theorem. The Annals
of Mathematics. JSTOR. https://doi.org/10.2307/121093
chicago: Kaloshin, Vadim. “An Extension of the Artin-Mazur Theorem.” The Annals
of Mathematics. JSTOR, 1999. https://doi.org/10.2307/121093.
ieee: V. Kaloshin, “An extension of the Artin-Mazur theorem,” The Annals of Mathematics,
vol. 150, no. 2. JSTOR, pp. 729–741, 1999.
ista: Kaloshin V. 1999. An extension of the Artin-Mazur theorem. The Annals of Mathematics.
150(2), 729–741.
mla: Kaloshin, Vadim. “An Extension of the Artin-Mazur Theorem.” The Annals of
Mathematics, vol. 150, no. 2, JSTOR, 1999, pp. 729–41, doi:10.2307/121093.
short: V. Kaloshin, The Annals of Mathematics 150 (1999) 729–741.
date_created: 2020-09-18T10:50:28Z
date_published: 1999-09-01T00:00:00Z
date_updated: 2021-01-12T08:19:53Z
day: '01'
doi: 10.2307/121093
extern: '1'
intvolume: ' 150'
issue: '2'
keyword:
- Statistics
- Probability and Uncertainty
- Statistics and Probability
language:
- iso: eng
month: '09'
oa_version: None
page: 729-741
publication: The Annals of Mathematics
publication_identifier:
issn:
- 0003-486X
publication_status: published
publisher: JSTOR
quality_controlled: '1'
status: public
title: An extension of the Artin-Mazur theorem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 150
year: '1999'
...
---
_id: '883'
abstract:
- lang: eng
text: Sympatric speciation, the origin of two or more species from a single local
population, has almost certainly been involved in formation of several species
flocks, and may be fairly common in nature. The most straightforward scenario
for sympatric speciation requires disruptive selection favouring two substantially
different phenotypes, and consists of the evolution of reproductive isolation
between them followed by the elimination of all intermediate phenotypes. Here
we use the hypergeometric phenotypic model to show that sympatric speciation is
possible even when fitness and mate choice depend on different quantitative traits,
so that speciation must involve formation of covariance between these traits.
The increase in the number of variable loci affecting fitness facilitates sympatric
speciation, whereas the increase in the number of variable loci affecting mate
choice has the opposite effect. These predictions may enable more cases of sympatric
speciation to be identified.
acknowledgement: This study was supported by a grant from the NSF.
article_processing_charge: No
article_type: original
author:
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov A, Kondrashov F. Interactions among quantitative traits in the course
of sympatric speciation. Nature. 1999;400(6742):351-354. doi:10.1038/22514
apa: Kondrashov, A., & Kondrashov, F. (1999). Interactions among quantitative
traits in the course of sympatric speciation. Nature. Nature Publishing
Group. https://doi.org/10.1038/22514
chicago: Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative
Traits in the Course of Sympatric Speciation.” Nature. Nature Publishing
Group, 1999. https://doi.org/10.1038/22514.
ieee: A. Kondrashov and F. Kondrashov, “Interactions among quantitative traits in
the course of sympatric speciation,” Nature, vol. 400, no. 6742. Nature
Publishing Group, pp. 351–354, 1999.
ista: Kondrashov A, Kondrashov F. 1999. Interactions among quantitative traits in
the course of sympatric speciation. Nature. 400(6742), 351–354.
mla: Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative
Traits in the Course of Sympatric Speciation.” Nature, vol. 400, no. 6742,
Nature Publishing Group, 1999, pp. 351–54, doi:10.1038/22514.
short: A. Kondrashov, F. Kondrashov, Nature 400 (1999) 351–354.
date_created: 2018-12-11T11:49:00Z
date_published: 1999-07-01T00:00:00Z
date_updated: 2023-04-13T10:33:44Z
day: '01'
doi: 10.1038/22514
extern: '1'
external_id:
pmid:
- '10432111'
intvolume: ' 400'
issue: '6742'
language:
- iso: eng
month: '07'
oa_version: None
page: 351 - 354
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '6761'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions among quantitative traits in the course of sympatric speciation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 400
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3456'
abstract:
- lang: eng
text: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and
N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic
glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the
mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric
proteins, probably tetramers, formed by a variety of molecularly distinct subunits.
AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and
-D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional
molecular diversity of AMPARs is generated by alternative splicing of the flip-flop
module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily
assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants
have been identified for the NR1 subunit, and a new NR3 subunit has been discovered
recently. Considering all combinatorial possibilities, the molecular diversity
of glutamate-receptor channels is considerable (HOLLMANN, this volume).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Jean
full_name: Rossier, Jean
last_name: Rossier
citation:
ama: 'Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H,
eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339.
doi:10.1007/978-3-662-08022-1_9'
apa: Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants
controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In
P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS
(Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9
chicago: Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants
Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.”
In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and
Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9.
ieee: H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling
functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic
Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds.
Springer, 1999, pp. 309–339.
ista: 'Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional
properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate
Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.'
mla: Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties
of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors
in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer,
1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9.
short: H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic
Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339.
date_created: 2018-12-11T12:03:25Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:30:23Z
day: '01'
doi: 10.1007/978-3-662-08022-1_9
editor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 309 - 339
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2931'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular determinants controlling functional properties of AMPARs and NMDARs
in the mammalian CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3457'
abstract:
- lang: eng
text: Principal neurons and interneurons are the two main classes of cells in cortical
neuronal networks. Principal neurons (granule cells or pyramidal neurons) have
transregional axonal projections and release glutamate onto their postsynaptic
target cells. In contrast, interneurons have local, but often extensive, axonal
arborizations and use γ-aminobutyric acid (GABA) as a transmitter. Although interneurons
represent only approximately 10% of the neuronal population, they control the
electrical activity of the entire network (FREUND and BUZSÁKI 1996). Interneurons
forming inhibitory synapses on the somata or axon initial segments of their postsynaptic
target cells are thought to set the threshold of action potential initiation (MILES
et al. 1996) and can synchronize the collective activities of large principal
neuron ensembles (COBB et al. 1995). In contrast, interneurons establishing inhibitory
synapses mainly on dendrites could suppress dendritic Na+ or Ca2+ spikes (BUZSÁKI
et al. 1996; MILES et al. 1996) and, thus, regulate plasticity at glutamatergic
synapses in the cortex (DAVIES et al.1991).
alternative_title:
- Handbook of experimental pharmacology
article_processing_charge: No
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Arnd
full_name: Roth, Arnd
last_name: Roth
- first_name: Birol
full_name: Taskin, Birol
last_name: Taskin
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Geiger J, Roth A, Taskin B, Jonas PM. Glutamate-mediated synaptic excitation
of cortical interneurons. In: Monyer H, Jonas PM, eds. Ionotropic Glutamate
Receptors in the CNS. Vol 141. Springer; 1999:363-398. doi:10.1007/978-3-662-08022-1_11'
apa: Geiger, J., Roth, A., Taskin, B., & Jonas, P. M. (1999). Glutamate-mediated
synaptic excitation of cortical interneurons. In H. Monyer & P. M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 363–398). Springer.
https://doi.org/10.1007/978-3-662-08022-1_11
chicago: Geiger, Jörg, Arnd Roth, Birol Taskin, and Peter M Jonas. “Glutamate-Mediated
Synaptic Excitation of Cortical Interneurons.” In Ionotropic Glutamate Receptors
in the CNS, edited by Hannah Monyer and Peter M Jonas, 141:363–98. Springer,
1999. https://doi.org/10.1007/978-3-662-08022-1_11.
ieee: J. Geiger, A. Roth, B. Taskin, and P. M. Jonas, “Glutamate-mediated synaptic
excitation of cortical interneurons,” in Ionotropic Glutamate Receptors in
the CNS, vol. 141, H. Monyer and P. M. Jonas, Eds. Springer, 1999, pp. 363–398.
ista: 'Geiger J, Roth A, Taskin B, Jonas PM. 1999.Glutamate-mediated synaptic excitation
of cortical interneurons. In: Ionotropic Glutamate Receptors in the CNS. Handbook
of experimental pharmacology, vol. 141, 363–398.'
mla: Geiger, Jörg, et al. “Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.”
Ionotropic Glutamate Receptors in the CNS, edited by Hannah Monyer and
Peter M Jonas, vol. 141, Springer, 1999, pp. 363–98, doi:10.1007/978-3-662-08022-1_11.
short: J. Geiger, A. Roth, B. Taskin, P.M. Jonas, in:, H. Monyer, P.M. Jonas (Eds.),
Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 363–398.
date_created: 2018-12-11T12:03:26Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:25:46Z
day: '01'
doi: 10.1007/978-3-662-08022-1_11
editor:
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
extern: '1'
intvolume: ' 141'
language:
- iso: eng
month: '01'
oa_version: None
page: 363 - 398
publication: Ionotropic Glutamate Receptors in the CNS
publication_identifier:
isbn:
- '9783642085390'
publication_status: published
publisher: Springer
publist_id: '2930'
quality_controlled: '1'
status: public
title: Glutamate-mediated synaptic excitation of cortical interneurons
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 141
year: '1999'
...
---
_id: '3515'
abstract:
- lang: eng
text: Oscillations in neuronal networks are assumed to serve various physiological
functions, from coordination of motor patterns to perceptual binding of sensory
information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus.
Extracellular and intracellular activity was recorded from the CA1 and subicular
regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane.
in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s)
occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast
increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed
by large-amplitude rhythmic waves and associated action potentials at gamma and
beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally
synchronous and terminated relatively abruptly without post-ictal depression.
Single-pulse stimulation of the commissural input could trigger afterdischarges,
but only at times when they were about to occur. Commissural stimulation evoked
inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus
triggered an afterdischarge, the inhibitory postsynaptic potential was absent
and the cells remained depolarized during most of the afterdischarge. Afterdischarges
were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal
activity in intact, drug-free rats also revealed periodic excitability changes
in the hippocampal network at 0.025 Hz. These findings indicate the presence of
an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced
afterdischarges in susceptible animals. We hypothesize that a transient failure
of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence
of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.
acknowledgement: This work was supported by the Academy of Finland (32391) and the
NIH (NS34994, MH54671).
article_processing_charge: No
article_type: original
author:
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Nina
full_name: Nurminen, Nina
last_name: Nurminen
- first_name: Riitta
full_name: Miettinen, Riitta
last_name: Miettinen
- first_name: Jouni
full_name: Sirviö, Jouni
last_name: Sirviö
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025
Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience.
1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X
apa: Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari,
J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X
chicago: Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell
Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025
Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience.
Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X.
ieee: M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal
afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier,
pp. 735–743, 1999.
ista: Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki
G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges
in Wistar rats. Neuroscience. 94(3), 735–743.
mla: Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal
Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier,
1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X.
short: M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari,
G. Buzsáki, Neuroscience 94 (1999) 735–743.
date_created: 2018-12-11T12:03:44Z
date_published: 1999-10-01T00:00:00Z
date_updated: 2022-09-07T13:16:01Z
day: '01'
doi: 10.1016/S0306-4522(99)00367-X
extern: '1'
external_id:
pmid:
- '10579564'
intvolume: ' 94'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 735 - 743
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '2870'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar
rats
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3519'
abstract:
- lang: eng
text: 'In contrast to sensory cortical areas of the brain, the relevant physiological
inputs to the hippocampus, leading to selective activation of pyramidal cells,
are largely unknown. Pyramidal cells are thought to be phasically activated by
spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural
`space clamp'' method, which involved the confinement of the actively running
animal in a defined position in space (running wheel) and kept sensory inputs
constant. Twelve percent of the recorded CA1 pyramidal cells were selectively
active while the rat was running in the wheel. Cell firing was specific to the
direction of running and disappeared after rotating the recording apparatus. The
discharge frequency of pyramidal cells and interneurons was sustained as long
as the rat ran continuously in the wheel. Furthermore, the discharge frequency
of pyramidal cells and interneurons increased with increasing running velocity,
even though the frequency of hippocampal theta waves remained constant. The discharge
frequency of some `wheel-related'' pyramidal cells could increase more than 10-fold
between 10 and 100 cm/s, whereas the firing rate of `non-wheel'' cells remained
constantly low. We hypothesize that: (i) a necessary condition for place-specific
discharge of hippocampal pyramidal cells is the presence of theta oscillation;
and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal
cells as long as theta activity is present.'
acknowledgement: We thank M. Recce for continuous support, A. Berthoz for advice,
K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand
C. King for his comments on the manuscript. This work was supportedby NIH (NS34994,
MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State
Fellowship (A.C.) and the Soros Foundation (A.C.)
article_processing_charge: No
article_type: original
author:
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal
pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal
of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x
apa: Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained
activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’
European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x
chicago: Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki.
“Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a
Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999.
https://doi.org/10.1046/j.1460-9568.1999.00446.x.
ieee: A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation
of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European
Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999.
ista: Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of
hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European
Journal of Neuroscience. 11(1), 344–352.
mla: Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells
by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience,
vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x.
short: A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience
11 (1999) 344–352.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T13:09:08Z
day: '01'
doi: 10.1046/j.1460-9568.1999.00446.x
extern: '1'
external_id:
pmid:
- '9987037'
intvolume: ' 11'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 344 - 352
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2867'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sustained activation of hippocampal pyramidal cells by ‘space clamping' in
a running wheel
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 11
year: '1999'
...