---
_id: '3624'
abstract:
- lang: eng
text: 'The state of a diploid population segregating for two alleles at each of
n loci is described by 22(n) genotype frequencies, or equivalently, by allele
frequencies and by multilocus moments or cumulants of various orders. These measures
of linkage disequilibrium cannot usually be determined, both because one cannot
tell whether a gene came from the maternal or paternal gamete, and because such
a large number of parameters cannot be estimated even from large samples. Simplifying
assumptions must therefore be made. This paper sets out methods for estimating
multilocus genotype frequencies which are appropriate for unlinked neutral loci,
and for populations that are ultimately derived by mixing of two source populations.
In such a hybrid population, all multilocus associations depend primarily on the
number of loci involved that derive from the maternal genome, and the number derived
from the paternal genome Allele frequencies may differ across loci, and the contribution
of each locus to multilocus associations may be scaled by the difference in allele
frequency between source populations for that locus (δp ≤ 1). For example, the
cumulant describing the association between genes i, j, k from the maternal genome,
and genes i, l from the paternal genome is K(tJ,k,iλ*), = δp(i)/2 δp(J) δp(k)
δp(l) κ3,2. The state of the population is described by n allele frequencies;
n divergences, δp; and by a symmetric matrix of cumulants, κ(J,K) (J = 0 ,...,
n, K = 0 ,..., n). Expressions for these cumulants under short- and long-range
migration are given. Two methods for estimating the cumulants are described: a
simple method based on multivariate moments, and a maximum likelihood procedure,
which uses the Metropolis algorithm. Both methods perform well when tested against
simulations with two or four loci.'
acknowledgement: This work was supported by grant MMI09726 from the BBSRC/EPSRC, and
by the Darwin Trust of Edinburgh. I am grateful to W. G. Hill, L. Kruuk and M. Orive,
and to the referees, for their helpful comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Estimating multilocus linkage disequilibria. Heredity. 2000;84(3):373-389.
doi:10.1046/j.1365-2540.2000.00683.x
apa: Barton, N. H. (2000). Estimating multilocus linkage disequilibria. Heredity.
Nature Publishing Group. https://doi.org/10.1046/j.1365-2540.2000.00683.x
chicago: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity.
Nature Publishing Group, 2000. https://doi.org/10.1046/j.1365-2540.2000.00683.x.
ieee: N. H. Barton, “Estimating multilocus linkage disequilibria,” Heredity,
vol. 84, no. 3. Nature Publishing Group, pp. 373–389, 2000.
ista: Barton NH. 2000. Estimating multilocus linkage disequilibria. Heredity. 84(3),
373–389.
mla: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity,
vol. 84, no. 3, Nature Publishing Group, 2000, pp. 373–89, doi:10.1046/j.1365-2540.2000.00683.x.
short: N.H. Barton, Heredity 84 (2000) 373–389.
date_created: 2018-12-11T12:04:18Z
date_published: 2000-03-01T00:00:00Z
date_updated: 2023-05-02T12:04:03Z
day: '01'
doi: 10.1046/j.1365-2540.2000.00683.x
extern: '1'
external_id:
pmid:
- '10762407'
intvolume: ' 84'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/6886830
month: '03'
oa_version: None
page: 373 - 389
pmid: 1
publication: Heredity
publication_identifier:
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2759'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimating multilocus linkage disequilibria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3798'
abstract:
- lang: eng
text: Glutamate is the main excitatory transmitter in the mammalian CNS, mediating
fast synaptic transmission primarily by activation of AMPA-type glutamate receptor
channels. Both synaptic structure and a cell-specific molecular switch in the
AMPA receptor subunit expression are involved in the regulation of the synaptic
signaling time course.
acknowledgement: I thank Drs. J.R.P. Geiger, K. Haverkampf, and B. Taskin for helpful
discussions. This review is based on a lecture given in Lisbon in March 1998 on
the occasion of the first award of the Medinfar European Prize in Physiology. My
studies are supported by the Deutsche Forschungsgemeinschaft, the German Israeli
Foundation, and the Human Frontiers Science Program Organization. I regret that
many relevant papers could not be cited due to editorial restric-tions on the maximum
number of references.
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Jonas PM. The time course of signaling at central glutamatergic synapses. Physiology.
2000;15(2):83-89. doi:10.1152/physiologyonline.2000.15.2.83
apa: Jonas, P. M. (2000). The time course of signaling at central glutamatergic
synapses. Physiology. American Physiological Society. https://doi.org/10.1152/physiologyonline.2000.15.2.83
chicago: Jonas, Peter M. “The Time Course of Signaling at Central Glutamatergic
Synapses.” Physiology. American Physiological Society, 2000. https://doi.org/10.1152/physiologyonline.2000.15.2.83.
ieee: P. M. Jonas, “The time course of signaling at central glutamatergic synapses,”
Physiology, vol. 15, no. 2. American Physiological Society, pp. 83–89,
2000.
ista: Jonas PM. 2000. The time course of signaling at central glutamatergic synapses.
Physiology. 15(2), 83–89.
mla: Jonas, Peter M. “The Time Course of Signaling at Central Glutamatergic Synapses.”
Physiology, vol. 15, no. 2, American Physiological Society, 2000, pp. 83–89,
doi:10.1152/physiologyonline.2000.15.2.83.
short: P.M. Jonas, Physiology 15 (2000) 83–89.
date_created: 2018-12-11T12:05:14Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-02T11:57:50Z
day: '01'
doi: 10.1152/physiologyonline.2000.15.2.83
extern: '1'
external_id:
pmid:
- '11390884'
intvolume: ' 15'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 83 - 89
pmid: 1
publication: Physiology
publication_identifier:
issn:
- 1548-9213
publication_status: published
publisher: American Physiological Society
publist_id: '2412'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The time course of signaling at central glutamatergic synapses
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2000'
...
---
_id: '3923'
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
the Journal of the Boehringer Ingelheim Fonds. 2000;15(1):68-71.'
apa: 'Cremer, S. (2000). Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
The Journal of the Boehringer Ingelheim Fonds. Hippokrates.'
chicago: 'Cremer, Sylvia. “Paternity Analysis with AFLPs in Cardiocondyla Ants.”
Futura: The Journal of the Boehringer Ingelheim Fonds. Hippokrates, 2000.'
ieee: 'S. Cremer, “Paternity analysis with AFLPs in Cardiocondyla ants,” Futura:
the Journal of the Boehringer Ingelheim Fonds, vol. 15, no. 1. Hippokrates,
pp. 68–71, 2000.'
ista: 'Cremer S. 2000. Paternity analysis with AFLPs in Cardiocondyla ants. Futura:
the Journal of the Boehringer Ingelheim Fonds. 15(1), 68–71.'
mla: 'Cremer, Sylvia. “Paternity Analysis with AFLPs in Cardiocondyla Ants.” Futura:
The Journal of the Boehringer Ingelheim Fonds, vol. 15, no. 1, Hippokrates,
2000, pp. 68–71.'
short: 'S. Cremer, Futura: The Journal of the Boehringer Ingelheim Fonds 15 (2000)
68–71.'
date_created: 2018-12-11T12:05:55Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-02T11:47:47Z
day: '01'
extern: '1'
intvolume: ' 15'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 68 - 71
publication: 'Futura: the Journal of the Boehringer Ingelheim Fonds'
publication_identifier:
issn:
- 0179-6372
publication_status: published
publisher: Hippokrates
publist_id: '2228'
status: public
title: Paternity analysis with AFLPs in Cardiocondyla ants
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2000'
...
---
_id: '4004'
abstract:
- lang: eng
text: In this paper we introduce the abacus model of a simplex and use it to subdivide
a d-simplex into k(d) d-simplices all of the same volume and shape characteristics.
The construction is an extension of the subdivision method of Freudenthal [3]
and has been used by Goodman and Peters [4] to design smooth manifolds.
acknowledgement: NSF under Grant DMS 98-73945, NSF under Grant CCR-96-19542 and by
ARO under Grant DAAG55- 98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Daniel
full_name: Grayson, Daniel
last_name: Grayson
citation:
ama: Edelsbrunner H, Grayson D. Edgewise subdivision of a simplex. Discrete &
Computational Geometry. 2000;24(4):707-719. doi:10.1007/s004540010063
apa: Edelsbrunner, H., & Grayson, D. (2000). Edgewise subdivision of a simplex.
Discrete & Computational Geometry. Springer. https://doi.org/10.1007/s004540010063
chicago: Edelsbrunner, Herbert, and Daniel Grayson. “Edgewise Subdivision of a Simplex.”
Discrete & Computational Geometry. Springer, 2000. https://doi.org/10.1007/s004540010063.
ieee: H. Edelsbrunner and D. Grayson, “Edgewise subdivision of a simplex,” Discrete
& Computational Geometry, vol. 24, no. 4. Springer, pp. 707–719, 2000.
ista: Edelsbrunner H, Grayson D. 2000. Edgewise subdivision of a simplex. Discrete
& Computational Geometry. 24(4), 707–719.
mla: Edelsbrunner, Herbert, and Daniel Grayson. “Edgewise Subdivision of a Simplex.”
Discrete & Computational Geometry, vol. 24, no. 4, Springer, 2000,
pp. 707–19, doi:10.1007/s004540010063.
short: H. Edelsbrunner, D. Grayson, Discrete & Computational Geometry 24 (2000)
707–719.
date_created: 2018-12-11T12:06:23Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-05-02T11:43:59Z
day: '01'
doi: 10.1007/s004540010063
extern: '1'
intvolume: ' 24'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 707 - 719
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2119'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edgewise subdivision of a simplex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 24
year: '2000'
...
---
_id: '4008'
abstract:
- lang: eng
text: We formalize a notion of topological simplification within the framework of
a filtration, which is the history of a growing complex. We classify a topological
change that happens during growth as either a feature or noise depending on its
life-time or persistence within the filtration. We give fast algorithms for computing
persistence and experimental evidence for their speed and utility.
acknowledgement: Research by the first and third authors is partially supported by
ARO under grant DAAG55-98-1-0177. Research by the first author is also partially
supported by NSF under grant CCR-97-12088.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: David
full_name: Letscher, David
last_name: Letscher
- first_name: Afra
full_name: Zomorodian, Afra
last_name: Zomorodian
citation:
ama: 'Edelsbrunner H, Letscher D, Zomorodian A. Topological persistance and simplification.
In: Proceedings 41st Annual Symposium on Foundations of Computer Science.
IEEE; 2000:454-463. doi:10.1109/SFCS.2000.892133'
apa: 'Edelsbrunner, H., Letscher, D., & Zomorodian, A. (2000). Topological persistance
and simplification. In Proceedings 41st Annual Symposium on Foundations of
Computer Science (pp. 454–463). Washington, DC, United States: IEEE. https://doi.org/10.1109/SFCS.2000.892133'
chicago: Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological
Persistance and Simplification.” In Proceedings 41st Annual Symposium on Foundations
of Computer Science, 454–63. IEEE, 2000. https://doi.org/10.1109/SFCS.2000.892133.
ieee: H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistance
and simplification,” in Proceedings 41st Annual Symposium on Foundations of
Computer Science, Washington, DC, United States, 2000, pp. 454–463.
ista: 'Edelsbrunner H, Letscher D, Zomorodian A. 2000. Topological persistance and
simplification. Proceedings 41st Annual Symposium on Foundations of Computer Science.
FOCS: Foundations of Computer Science, 454–463.'
mla: Edelsbrunner, Herbert, et al. “Topological Persistance and Simplification.”
Proceedings 41st Annual Symposium on Foundations of Computer Science, IEEE,
2000, pp. 454–63, doi:10.1109/SFCS.2000.892133.
short: H. Edelsbrunner, D. Letscher, A. Zomorodian, in:, Proceedings 41st Annual
Symposium on Foundations of Computer Science, IEEE, 2000, pp. 454–463.
conference:
end_date: 2000-11-14
location: Washington, DC, United States
name: 'FOCS: Foundations of Computer Science'
start_date: 2000-11-12
date_created: 2018-12-11T12:06:24Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-04-25T06:53:21Z
day: '01'
doi: 10.1109/SFCS.2000.892133
extern: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 454 - 463
publication: Proceedings 41st Annual Symposium on Foundations of Computer Science
publication_identifier:
isbn:
- '0769508502'
publication_status: published
publisher: IEEE
publist_id: '2116'
quality_controlled: '1'
status: public
title: Topological persistance and simplification
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2000'
...
---
_id: '4009'
abstract:
- lang: eng
text: We study the maintenance of a simplicial grid or complex under changing density
requirements. The proposed method works in any fixed dimension and generates grids
by projecting cross-sections of a monotone simplicial complex that lives in one
dimension higher than the grid. The density of the grid is adapted by locally
moving the cross-section up or down along the extra dimension.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Roman
full_name: Waupotitsch, Roman
last_name: Waupotitsch
citation:
ama: Edelsbrunner H, Waupotitsch R. Adaptive simplicial grids from cross-sections
of monotone complexes. International Journal of Computational Geometry and
Applications. 2000;10(3):267-284. doi:10.1142/S0218195900000164
apa: Edelsbrunner, H., & Waupotitsch, R. (2000). Adaptive simplicial grids from
cross-sections of monotone complexes. International Journal of Computational
Geometry and Applications. World Scientific Publishing. https://doi.org/10.1142/S0218195900000164
chicago: Edelsbrunner, Herbert, and Roman Waupotitsch. “Adaptive Simplicial Grids
from Cross-Sections of Monotone Complexes.” International Journal of Computational
Geometry and Applications. World Scientific Publishing, 2000. https://doi.org/10.1142/S0218195900000164.
ieee: H. Edelsbrunner and R. Waupotitsch, “Adaptive simplicial grids from cross-sections
of monotone complexes,” International Journal of Computational Geometry and
Applications, vol. 10, no. 3. World Scientific Publishing, pp. 267–284, 2000.
ista: Edelsbrunner H, Waupotitsch R. 2000. Adaptive simplicial grids from cross-sections
of monotone complexes. International Journal of Computational Geometry and Applications.
10(3), 267–284.
mla: Edelsbrunner, Herbert, and Roman Waupotitsch. “Adaptive Simplicial Grids from
Cross-Sections of Monotone Complexes.” International Journal of Computational
Geometry and Applications, vol. 10, no. 3, World Scientific Publishing, 2000,
pp. 267–84, doi:10.1142/S0218195900000164.
short: H. Edelsbrunner, R. Waupotitsch, International Journal of Computational Geometry
and Applications 10 (2000) 267–284.
date_created: 2018-12-11T12:06:25Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-20T13:45:46Z
day: '01'
doi: 10.1142/S0218195900000164
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 267 - 284
publication: International Journal of Computational Geometry and Applications
publication_identifier:
issn:
- 0218-1959
publication_status: published
publisher: World Scientific Publishing
publist_id: '2117'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adaptive simplicial grids from cross-sections of monotone complexes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2000'
...
---
_id: '4010'
abstract:
- lang: eng
text: A sliver is a tetrahedron whose four vertices lie close to a plane and whose
orthogonal projection to that plane is a convex quadrilateral with no short edge.
Slivers are notoriously common in 3-dimensional Delaunay triangulations even for
well-spaced point sets. We show that, if the Delaunay triangulation has the ratio
property introduced in Miller et al. [1995], then there is an assignment of weights
so the weighted Delaunay triangulation contains no slivers. We also give an algorithm
to compute such a weight assignment.
acknowledgement: NSF under grant DMS 98-73945, NSF under grant CCR 96-19542 and ARO
under grant DAAG-55-98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Siu
full_name: Cheng, Siu
last_name: Cheng
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Facello, Michael
last_name: Facello
- first_name: Shang
full_name: Teng, Shang
last_name: Teng
citation:
ama: Cheng S, Dey T, Edelsbrunner H, Facello M, Teng S. Sliver exudation. Journal
of the ACM. 2000;47(5):883-904. doi:10.1145/355483.355487
apa: Cheng, S., Dey, T., Edelsbrunner, H., Facello, M., & Teng, S. (2000). Sliver
exudation. Journal of the ACM. ACM. https://doi.org/10.1145/355483.355487
chicago: Cheng, Siu, Tamal Dey, Herbert Edelsbrunner, Michael Facello, and Shang
Teng. “Sliver Exudation.” Journal of the ACM. ACM, 2000. https://doi.org/10.1145/355483.355487.
ieee: S. Cheng, T. Dey, H. Edelsbrunner, M. Facello, and S. Teng, “Sliver exudation,”
Journal of the ACM, vol. 47, no. 5. ACM, pp. 883–904, 2000.
ista: Cheng S, Dey T, Edelsbrunner H, Facello M, Teng S. 2000. Sliver exudation.
Journal of the ACM. 47(5), 883–904.
mla: Cheng, Siu, et al. “Sliver Exudation.” Journal of the ACM, vol. 47,
no. 5, ACM, 2000, pp. 883–904, doi:10.1145/355483.355487.
short: S. Cheng, T. Dey, H. Edelsbrunner, M. Facello, S. Teng, Journal of the ACM
47 (2000) 883–904.
date_created: 2018-12-11T12:06:25Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-04-21T08:58:30Z
day: '01'
doi: 10.1145/355483.355487
extern: '1'
intvolume: ' 47'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 883 - 904
publication: Journal of the ACM
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: ACM
publist_id: '2118'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sliver exudation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '2000'
...
---
_id: '4147'
abstract:
- lang: eng
text: We have developed a protocol to perform a genetic screen for zygotic mutations
affecting embryogenesis on the protochordate Ciona intestinalis. The choice of
this taxon, whose phylogenetic position places it at the basis of the chordates
as one the most primitive vertebrate relatives, could allow to address several
evolutionary questions. The protochordates share many morphological features with
the vertebrates, in primis the presence of a notochord. Ciona intestinalis shows
several ideal features for a mutational analysis, such as external development
and larvae made of a limited number of cells and cell types. Detailed cell lineage
studies are available. The haploid genome size is comparable to the size of the
Drosophila haploid genome. We have optimised conditions for chemical mutagenesis
studying the efficiency at which different concentration of N-ethyl-N-nitrosourea
(ENU) can induce mutations. Because the adult Ciona are hermaphrodites, we are
performing a one-generation screen. The induced mutations are identified by visual
inspection of developmental stages. We report the preliminary results from our
screen including examples of the different classes of mutant phenotypes found
so far.
article_processing_charge: No
article_type: original
author:
- first_name: Paolo
full_name: Sordino, Paolo
last_name: Sordino
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Paola
full_name: Cirino, Paola
last_name: Cirino
- first_name: Alfonso
full_name: Toscano, Alfonso
last_name: Toscano
- first_name: Paola
full_name: Giuliano, Paola
last_name: Giuliano
- first_name: Rita
full_name: Marino, Rita
last_name: Marino
- first_name: Maria
full_name: Pinto, Maria
last_name: Pinto
- first_name: Rosaria
full_name: De Santis, Rosaria
last_name: De Santis
citation:
ama: Sordino P, Heisenberg C-PJ, Cirino P, et al. A mutational approach to the study
of development of the protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia.
2000;85(2):173-176. doi:10.1080/00364827.2000.10414567
apa: Sordino, P., Heisenberg, C.-P. J., Cirino, P., Toscano, A., Giuliano, P., Marino,
R., … De Santis, R. (2000). A mutational approach to the study of development
of the protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia. Taylor
& Francis. https://doi.org/10.1080/00364827.2000.10414567
chicago: Sordino, Paolo, Carl-Philipp J Heisenberg, Paola Cirino, Alfonso Toscano,
Paola Giuliano, Rita Marino, Maria Pinto, and Rosaria De Santis. “A Mutational
Approach to the Study of Development of the Protochordate Ciona Intestinalis (Tunicata,
Chordata).” Sarsia. Taylor & Francis, 2000. https://doi.org/10.1080/00364827.2000.10414567.
ieee: P. Sordino et al., “A mutational approach to the study of development
of the protochordate Ciona intestinalis (Tunicata, Chordata),” Sarsia,
vol. 85, no. 2. Taylor & Francis, pp. 173–176, 2000.
ista: Sordino P, Heisenberg C-PJ, Cirino P, Toscano A, Giuliano P, Marino R, Pinto
M, De Santis R. 2000. A mutational approach to the study of development of the
protochordate Ciona intestinalis (Tunicata, Chordata). Sarsia. 85(2), 173–176.
mla: Sordino, Paolo, et al. “A Mutational Approach to the Study of Development of
the Protochordate Ciona Intestinalis (Tunicata, Chordata).” Sarsia, vol.
85, no. 2, Taylor & Francis, 2000, pp. 173–76, doi:10.1080/00364827.2000.10414567.
short: P. Sordino, C.-P.J. Heisenberg, P. Cirino, A. Toscano, P. Giuliano, R. Marino,
M. Pinto, R. De Santis, Sarsia 85 (2000) 173–176.
date_created: 2018-12-11T12:07:13Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-19T14:50:58Z
day: '01'
doi: 10.1080/00364827.2000.10414567
extern: '1'
intvolume: ' 85'
issue: '2'
language:
- iso: eng
month: '06'
oa_version: None
page: 173 - 176
publication: Sarsia
publication_identifier:
issn:
- 0036-4827
publication_status: published
publisher: Taylor & Francis
publist_id: '1972'
quality_controlled: '1'
status: public
title: A mutational approach to the study of development of the protochordate Ciona
intestinalis (Tunicata, Chordata)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 85
year: '2000'
...
---
_id: '4197'
abstract:
- lang: eng
text: Vertebrate gastrulation involves the specification and coordinated movement
of large populations of cells that give rise to the ectodermal, mesodermal and
endodermal germ layers. Although many of the genes involved in the specification
of cell identity during this process have been identified, little is known of
the genes that coordinate cell movement. Here we show that the zebrafish silberblick
(slb) locus(1) encodes Wnt11 and that Slb/Wnt11 activity is required for cells
to undergo correct convergent extension movements during gastrulation. In the
absence of Slb/Wnt11 function, abnormal extension of axial tissue results in cyclopia
and other midline defects in the head(2). The requirement for Slb/Wnt11 is cell
non-autonomous, and our results indicate that the correct extension of axial tissue
is at least partly dependent on medio-lateral cell intercalation in paraxial tissue.
We also show that the slb phenotype is rescued by a truncated form of Dishevelled
that does not signal through the canonical Wnt pathway(3), suggesting that, as
in flies(4), Wnt signalling might mediate morphogenetic events through a divergent
signal transduction cascade. Our results provide genetic and experimental evidence
that Wnt activity in lateral tissues has a crucial role in driving the convergent
extension movements underlying vertebrate gastrulation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Masazumi
full_name: Tada, Masazumi
last_name: Tada
- first_name: Gerd
full_name: Rauch, Gerd
last_name: Rauch
- first_name: Leonor
full_name: Saúde, Leonor
last_name: Saúde
- first_name: Miguel
full_name: Concha, Miguel
last_name: Concha
- first_name: Robert
full_name: Geisler, Robert
last_name: Geisler
- first_name: Derek
full_name: Stemple, Derek
last_name: Stemple
- first_name: James
full_name: Smith, James
last_name: Smith
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
citation:
ama: Heisenberg C-PJ, Tada M, Rauch G, et al. Silberblick/Wnt11 mediates convergent
extension movements during zebrafish gastrulation. Nature. 2000;405(6782):76-81.
doi:10.1038/35011068
apa: Heisenberg, C.-P. J., Tada, M., Rauch, G., Saúde, L., Concha, M., Geisler,
R., … Wilson, S. (2000). Silberblick/Wnt11 mediates convergent extension movements
during zebrafish gastrulation. Nature. Nature Publishing Group. https://doi.org/10.1038/35011068
chicago: Heisenberg, Carl-Philipp J, Masazumi Tada, Gerd Rauch, Leonor Saúde, Miguel
Concha, Robert Geisler, Derek Stemple, James Smith, and Stephen Wilson. “Silberblick/Wnt11
Mediates Convergent Extension Movements during Zebrafish Gastrulation.” Nature.
Nature Publishing Group, 2000. https://doi.org/10.1038/35011068.
ieee: C.-P. J. Heisenberg et al., “Silberblick/Wnt11 mediates convergent
extension movements during zebrafish gastrulation,” Nature, vol. 405, no.
6782. Nature Publishing Group, pp. 76–81, 2000.
ista: Heisenberg C-PJ, Tada M, Rauch G, Saúde L, Concha M, Geisler R, Stemple D,
Smith J, Wilson S. 2000. Silberblick/Wnt11 mediates convergent extension movements
during zebrafish gastrulation. Nature. 405(6782), 76–81.
mla: Heisenberg, Carl-Philipp J., et al. “Silberblick/Wnt11 Mediates Convergent
Extension Movements during Zebrafish Gastrulation.” Nature, vol. 405, no.
6782, Nature Publishing Group, 2000, pp. 76–81, doi:10.1038/35011068.
short: C.-P.J. Heisenberg, M. Tada, G. Rauch, L. Saúde, M. Concha, R. Geisler, D.
Stemple, J. Smith, S. Wilson, Nature 405 (2000) 76–81.
date_created: 2018-12-11T12:07:32Z
date_published: 2000-05-04T00:00:00Z
date_updated: 2023-04-19T14:40:45Z
day: '04'
doi: 10.1038/35011068
extern: '1'
external_id:
pmid:
- '10811221 '
intvolume: ' 405'
issue: '6782'
language:
- iso: eng
month: '05'
oa_version: None
page: 76 - 81
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '1921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Silberblick/Wnt11 mediates convergent extension movements during zebrafish
gastrulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 405
year: '2000'
...
---
_id: '4268'
article_processing_charge: No
author:
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Partridge L, Barton NH. Evolving evolvability. Nature. 2000;407(6803):457-458.
doi:10.1038/35035173
apa: Partridge, L., & Barton, N. H. (2000). Evolving evolvability. Nature.
Nature Publishing Group. https://doi.org/10.1038/35035173
chicago: Partridge, Linda, and Nicholas H Barton. “Evolving Evolvability.” Nature.
Nature Publishing Group, 2000. https://doi.org/10.1038/35035173.
ieee: L. Partridge and N. H. Barton, “Evolving evolvability,” Nature, vol.
407, no. 6803. Nature Publishing Group, pp. 457–458, 2000.
ista: Partridge L, Barton NH. 2000. Evolving evolvability. Nature. 407(6803), 457–458.
mla: Partridge, Linda, and Nicholas H. Barton. “Evolving Evolvability.” Nature,
vol. 407, no. 6803, Nature Publishing Group, 2000, pp. 457–58, doi:10.1038/35035173.
short: L. Partridge, N.H. Barton, Nature 407 (2000) 457–458.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-04-19T14:37:19Z
day: '01'
doi: 10.1038/35035173
extern: '1'
intvolume: ' 407'
issue: '6803'
language:
- iso: eng
month: '09'
oa_version: None
page: 457 - 458
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '1823'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolving evolvability
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 407
year: '2000'
...
---
_id: '4269'
article_processing_charge: No
article_type: original
author:
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: Coyne J, Barton NH, Turelli M. Is Wright’s shifting balance process important
in evolution? Evolution; International Journal of Organic Evolution. 2000;54(1):306-317.
doi:10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
apa: Coyne, J., Barton, N. H., & Turelli, M. (2000). Is Wright’s shifting balance
process important in evolution? Evolution; International Journal of Organic
Evolution. Wiley-Blackwell. https://doi.org/10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
chicago: Coyne, Jerry, Nicholas H Barton, and Michael Turelli. “Is Wright’s Shifting
Balance Process Important in Evolution?” Evolution; International Journal of
Organic Evolution. Wiley-Blackwell, 2000. https://doi.org/10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2.
ieee: J. Coyne, N. H. Barton, and M. Turelli, “Is Wright’s shifting balance process
important in evolution?,” Evolution; International Journal of Organic Evolution,
vol. 54, no. 1. Wiley-Blackwell, pp. 306–317, 2000.
ista: Coyne J, Barton NH, Turelli M. 2000. Is Wright’s shifting balance process
important in evolution? Evolution; International Journal of Organic Evolution.
54(1), 306–317.
mla: Coyne, Jerry, et al. “Is Wright’s Shifting Balance Process Important in Evolution?”
Evolution; International Journal of Organic Evolution, vol. 54, no. 1,
Wiley-Blackwell, 2000, pp. 306–17, doi:10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2.
short: J. Coyne, N.H. Barton, M. Turelli, Evolution; International Journal of Organic
Evolution 54 (2000) 306–317.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-02-01T00:00:00Z
date_updated: 2023-04-19T12:48:29Z
day: '01'
doi: 10.1554/0014-3820(2000)054[0306:IWSSBP]2.0.CO;2
extern: '1'
external_id:
pmid:
- '10937209'
intvolume: ' 54'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 306 - 317
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1821'
quality_controlled: '1'
status: public
title: Is Wright’s shifting balance process important in evolution?
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 54
year: '2000'
...
---
_id: '4270'
abstract:
- lang: eng
text: 'A coalescence-based maximum-likelihood method is presented that aims to (i)
detect diversity-reducing events in the recent history of a population and (ii)
distinguish between demographic (e.g., bottlenecks) and selective causes (selective
sweep) of a recent reduction of genetic variability. The former goal is achieved
by taking account of the distortion in the shape of gene genealogies generated
by diversity-reducing events: gene trees tend to be more star-like than under
the standard coalescent. The latter issue is addressed by comparing patterns between
loci: demographic events apply to the whole genome whereas selective events affect
distinct regions of the genome to a varying extent. The maximum-likelihood approach
allows one to estimate the time and strength of diversity-reducing events and
to choose among competing hypotheses. An application to sequence data from an
African population of Drosophila melanogaster shows that the bottleneck hypothesis
is unlikely and that one or several selective sweeps probably occurred in the
recent history of this population.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicolas
full_name: Galtier, Nicolas
last_name: Galtier
- first_name: Frantz
full_name: Depaulis, Frantz
last_name: Depaulis
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Galtier N, Depaulis F, Barton NH. Detecting bottlenecks and selective sweeps
from DNA sequence polymorphism. Genetics. 2000;155(2):981-987. doi:10.1093/genetics/155.2.981
apa: Galtier, N., Depaulis, F., & Barton, N. H. (2000). Detecting bottlenecks
and selective sweeps from DNA sequence polymorphism. Genetics. Genetics
Society of America. https://doi.org/10.1093/genetics/155.2.981
chicago: Galtier, Nicolas, Frantz Depaulis, and Nicholas H Barton. “Detecting Bottlenecks
and Selective Sweeps from DNA Sequence Polymorphism.” Genetics. Genetics
Society of America, 2000. https://doi.org/10.1093/genetics/155.2.981.
ieee: N. Galtier, F. Depaulis, and N. H. Barton, “Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism,” Genetics, vol. 155, no. 2. Genetics
Society of America, pp. 981–987, 2000.
ista: Galtier N, Depaulis F, Barton NH. 2000. Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism. Genetics. 155(2), 981–987.
mla: Galtier, Nicolas, et al. “Detecting Bottlenecks and Selective Sweeps from DNA
Sequence Polymorphism.” Genetics, vol. 155, no. 2, Genetics Society of
America, 2000, pp. 981–87, doi:10.1093/genetics/155.2.981.
short: N. Galtier, F. Depaulis, N.H. Barton, Genetics 155 (2000) 981–987.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-19T14:03:56Z
day: '01'
doi: 10.1093/genetics/155.2.981
extern: '1'
external_id:
pmid:
- '10835415'
intvolume: ' 155'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461106/
month: '06'
oa: 1
oa_version: None
page: 981 - 987
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1822'
status: public
title: Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 155
year: '2000'
...
---
_id: '4271'
abstract:
- lang: eng
text: "Within hybrid zones that are maintained by a balance between selection and
dispersal, linkage disequilibrium is generated by the mixing of divergent populations.
This linkage disequilibrium causes selection on each locus to act on all other
loci, thereby steepening dines, and generating a barrier to gene flow. Diffusion
models predict simple relations between the strength of linkage disequilibrium
and the dispersal rate, σ, and between the barrier to gene flow, B, and the reduction
in mean fitness, W̄. The aim of this paper is to test the accuracy of these predictions
by comparison with an exact deterministic model of unlinked loci (r = 0.5). Disruptive
selection acts on the proportion of alleles from the parental populations (p,
q): W = exp[-S(4pq)(β)], such that the least fit genotype has fitness e(-S). Where
β << 1, fitness is reduced for a wide range of intermediate genotypes; where
β >> 1, fitness is only reduced for those genotypes close to p = 0.5. Even
with strong epistasis, linkage disequilibria are close to σ2p'(i)p'(j)/r(ij),
where p'(i), p'(j) are the gradients in allele frequency at loci i, j. The barrier
to gene flow, which is reflected in the steepening of neutral dines, is given
by B = ∫(-∞)(∞) (W̄(1/r̄)-1) dx, where r̄, the harmonic mean recombination rate
between the neural and selected loci, is here 0.5. This is a close approximation
for weak selection, but underestimates B for strong selection. The barrier is
stronger for small β, because hybrid fitness is then reduced over a wider range
of p. The widths of the selected dines are harder to predict: though simple approximations
are accurate for β = 1, they become inaccurate for extreme β because, then, fitness
changes sharply with p. Estimates of gene number, made from neutral dines on the
assumption that selection acts against heterozygotes, are accurate for weak selection
when β = 1; however, for strong selection, gene number is overestimated. For β
> 1, gene number is systematically overestimated and, conversely, when β <
1, it is underestimated.\r\n"
acknowledgement: We are grateful to Loeske Kruuk and Michael Turelli for their helpful
comments on the manuscript. N.B. was supported by grants GR3/11635 from the NERC
and GR/L10048 from the EPSRC, and by the Darwin Trust of Edinburgh. M.S. was supported
by a graduate student fellowship from the Yale Institute for Biospheric Studies.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Max
full_name: Shpak, Max
last_name: Shpak
citation:
ama: Barton NH, Shpak M. The effects of epistasis on the structure of hybrid zones.
Genetical Research. 2000;75(2):179-198. doi:10.1017/S0016672399004334
apa: Barton, N. H., & Shpak, M. (2000). The effects of epistasis on the structure
of hybrid zones. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672399004334
chicago: Barton, Nicholas H, and Max Shpak. “The Effects of Epistasis on the Structure
of Hybrid Zones.” Genetical Research. Cambridge University Press, 2000.
https://doi.org/10.1017/S0016672399004334.
ieee: N. H. Barton and M. Shpak, “The effects of epistasis on the structure of hybrid
zones,” Genetical Research, vol. 75, no. 2. Cambridge University Press,
pp. 179–198, 2000.
ista: Barton NH, Shpak M. 2000. The effects of epistasis on the structure of hybrid
zones. Genetical Research. 75(2), 179–198.
mla: Barton, Nicholas H., and Max Shpak. “The Effects of Epistasis on the Structure
of Hybrid Zones.” Genetical Research, vol. 75, no. 2, Cambridge University
Press, 2000, pp. 179–98, doi:10.1017/S0016672399004334.
short: N.H. Barton, M. Shpak, Genetical Research 75 (2000) 179–198.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-04-19T09:58:36Z
day: '01'
doi: 10.1017/S0016672399004334
extern: '1'
external_id:
pmid:
- '10816975'
intvolume: ' 75'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 179 - 198
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1819'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effects of epistasis on the structure of hybrid zones
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...
---
_id: '4272'
abstract:
- lang: eng
text: 'Analysis of multilocus evolution is usually intractable for more than n ~
10 genes, because the frequencies of very large numbers of genotypes must be followed.
An exact analysis of up to n ~ 100 loci is feasible for a symmetrical model, in
which a set of unlinked loci segregate for two alleles (labeled ''0'' and ''1'')
with interchangeable effects on fitness. All haploid genotypes with the same number
of 1 alleles can then remain equally frequent. However, such a symmetrical solution
may be unstable: for example, under stabilizing selection, populations tend to
fix any one genotype which approaches the optimum. Here, we show how the 2'' x
2'' stability matrix can be decomposed into a set of matrices, each no larger
than n x n. This allows the stability of symmetrical solutions to be determined.
We apply the method to stabilizing and disruptive selection in a single deme and
to selection against heterozygotes in a linear cline. (C) 2000 Academic Press.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Max
full_name: Shpak, Max
last_name: Shpak
citation:
ama: Barton NH, Shpak M. The stability of symmetrical solutions to polygenic models.
Theoretical Population Biology. 2000;57(3):249-263. doi:10.1006/tpbi.2000.1455
apa: Barton, N. H., & Shpak, M. (2000). The stability of symmetrical solutions
to polygenic models. Theoretical Population Biology. Academic Press. https://doi.org/10.1006/tpbi.2000.1455
chicago: Barton, Nicholas H, and Max Shpak. “The Stability of Symmetrical Solutions
to Polygenic Models.” Theoretical Population Biology. Academic Press, 2000.
https://doi.org/10.1006/tpbi.2000.1455.
ieee: N. H. Barton and M. Shpak, “The stability of symmetrical solutions to polygenic
models,” Theoretical Population Biology, vol. 57, no. 3. Academic Press,
pp. 249–263, 2000.
ista: Barton NH, Shpak M. 2000. The stability of symmetrical solutions to polygenic
models. Theoretical Population Biology. 57(3), 249–263.
mla: Barton, Nicholas H., and Max Shpak. “The Stability of Symmetrical Solutions
to Polygenic Models.” Theoretical Population Biology, vol. 57, no. 3, Academic
Press, 2000, pp. 249–63, doi:10.1006/tpbi.2000.1455.
short: N.H. Barton, M. Shpak, Theoretical Population Biology 57 (2000) 249–263.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-05-01T00:00:00Z
date_updated: 2023-04-19T12:36:39Z
day: '01'
doi: 10.1006/tpbi.2000.1455
extern: '1'
external_id:
pmid:
- '10828217'
intvolume: ' 57'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 249 - 263
pmid: 1
publication: Theoretical Population Biology
publication_identifier:
issn:
- 0040-5809
publication_status: published
publisher: Academic Press
publist_id: '1820'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The stability of symmetrical solutions to polygenic models
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '2000'
...
---
_id: '4273'
abstract:
- lang: eng
text: We review the various factors that limit adaptation by natural selection.
Recent discussion of constraints on selection and, conversely, of the factors
that enhance 'evolvability', have concentrated on the kinds of variation that
can be produced. Here, we emphasise that adaptation depends on how the various
evolutionary processes shape variation in populations. We survey the limits that
population genetics places on adaptive evolution, and discuss the relationship
between disparate literatures. BioEssays 22:1075-1084, 2000. (C) 2000 John Wiley
and Sons, Inc.
acknowledgement: We thank Brian Charlesworth, Toby Johnson, and two anonymous referees
for helpful discussions and criticism of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
citation:
ama: Barton NH, Partridge L. Limits to natural selection. BioEssays. 2000;22(12):1075-1084.
doi:10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
apa: Barton, N. H., & Partridge, L. (2000). Limits to natural selection. BioEssays.
Wiley-Blackwell. https://doi.org/10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
chicago: Barton, Nicholas H, and Linda Partridge. “Limits to Natural Selection.”
BioEssays. Wiley-Blackwell, 2000. https://doi.org/10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M.
ieee: N. H. Barton and L. Partridge, “Limits to natural selection,” BioEssays,
vol. 22, no. 12. Wiley-Blackwell, pp. 1075–1084, 2000.
ista: Barton NH, Partridge L. 2000. Limits to natural selection. BioEssays. 22(12),
1075–1084.
mla: Barton, Nicholas H., and Linda Partridge. “Limits to Natural Selection.” BioEssays,
vol. 22, no. 12, Wiley-Blackwell, 2000, pp. 1075–84, doi:10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M.
short: N.H. Barton, L. Partridge, BioEssays 22 (2000) 1075–1084.
date_created: 2018-12-11T12:07:58Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-04-19T09:49:52Z
day: '01'
doi: 10.1002/1521-1878(200012)22:12<1075::AID-BIES5>3.0.CO;2-M
extern: '1'
external_id:
pmid:
- '11084623'
intvolume: ' 22'
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 1075 - 1084
pmid: 1
publication: BioEssays
publication_identifier:
issn:
- 0265-9247
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1818'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limits to natural selection
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2000'
...
---
_id: '4274'
abstract:
- lang: eng
text: Selection on one or more genes inevitably perturbs other genes, even when
those genes have no direct effect on fitness. This article reviews the theory
of such genetic hitchhiking, concentrating on effects on neutral loci. Maynard
Smith and Haigh introduced the classical case where the perturbation is due to
a single favourable mutation. This is contrasted with the apparently distinct
effects of inherited variation in fitness due to loosely linked loci. A model
of fluctuating selection is analysed which bridges these alternative treatments.
When alleles sweep between extreme frequencies at a rate λ, the rate of drift
is increased by a factor (1 + E[1/pq]λ/(2(2λ + r))), where the recombination rate
r is much smaller than the strength of selection. In spatially structured populations,
the effects of any one substitution are weaker, and only cause a local increase
in the frequency of a neutral allele. This increase depends primarily on the rate
of recombination relative to selection (r/s), and more weakly, on the neighbourhood
size, Nb = 4πρσ2. Spatial subdivision may allow local selective sweeps to occur
more frequently than is indicated by the overall rate of molecular evolution.
However, it seems unlikely that such sweeps can be sufficiently frequent to increase
significantly the drift of neutral alleles.
acknowledgement: "I am grateful to B. Charlesworth and M.Slatkin for their helpful
comments. This work was supported by the Biotechnology\r\nand Biological Sciences
Research Council, the Natural Environment Research Council, and the Darwin Trust
of Edinburgh."
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London Series B, Biological Sciences. 2000;355(1403):1553-1562.
doi:10.1098/rstb.2000.0716
apa: Barton, N. H. (2000). Genetic hitchhiking. Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences. Royal Society
of London. https://doi.org/10.1098/rstb.2000.0716
chicago: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions
of the Royal Society of London. Series B, Biological Sciences. Royal Society
of London, 2000. https://doi.org/10.1098/rstb.2000.0716.
ieee: N. H. Barton, “Genetic hitchhiking,” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 355, no. 1403.
Royal Society of London, pp. 1553–1562, 2000.
ista: Barton NH. 2000. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London. Series B, Biological Sciences. 355(1403), 1553–1562.
mla: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences, vol. 355, no.
1403, Royal Society of London, 2000, pp. 1553–62, doi:10.1098/rstb.2000.0716.
short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
B, Biological Sciences 355 (2000) 1553–1562.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-11-29T00:00:00Z
date_updated: 2023-04-19T09:35:31Z
day: '29'
doi: 10.1098/rstb.2000.0716
extern: '1'
external_id:
pmid:
- '11127900'
intvolume: ' 355'
issue: '1403'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692896/
month: '11'
oa: 1
oa_version: None
page: 1553 - 1562
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society of London
publist_id: '1815'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic hitchhiking
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 355
year: '2000'
...
---
_id: '4275'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Differentiation. In: Encyclopedia of Biodiversity. Academic
Press; 2000:85-94. doi:10.1016/B0-12-226865-2/00070-5'
apa: Barton, N. H. (2000). Differentiation. In Encyclopedia of Biodiversity
(pp. 85–94). Academic Press. https://doi.org/10.1016/B0-12-226865-2/00070-5
chicago: Barton, Nicholas H. “Differentiation.” In Encyclopedia of Biodiversity,
85–94. Academic Press, 2000. https://doi.org/10.1016/B0-12-226865-2/00070-5.
ieee: N. H. Barton, “Differentiation,” in Encyclopedia of Biodiversity, Academic
Press, 2000, pp. 85–94.
ista: 'Barton NH. 2000.Differentiation. In: Encyclopedia of Biodiversity. , 85–94.'
mla: Barton, Nicholas H. “Differentiation.” Encyclopedia of Biodiversity,
Academic Press, 2000, pp. 85–94, doi:10.1016/B0-12-226865-2/00070-5.
short: N.H. Barton, in:, Encyclopedia of Biodiversity, Academic Press, 2000, pp.
85–94.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-04-19T09:39:55Z
day: '01'
doi: 10.1016/B0-12-226865-2/00070-5
extern: '1'
language:
- iso: eng
month: '10'
oa_version: None
page: 85 - 94
publication: Encyclopedia of Biodiversity
publication_identifier:
isbn:
- '9780122268656'
publication_status: published
publisher: Academic Press
publist_id: '1816'
status: public
title: Differentiation
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '4276'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Population genetics of multiple loci. Genetics Research.
2000;75(3):371-373. doi:10.1017/S0016672300239220
apa: Barton, N. H. (2000). Population genetics of multiple loci. Genetics Research.
Cambridge University Press. https://doi.org/10.1017/S0016672300239220
chicago: Barton, Nicholas H. “Population Genetics of Multiple Loci.” Genetics
Research. Cambridge University Press, 2000. https://doi.org/10.1017/S0016672300239220.
ieee: N. H. Barton, “Population genetics of multiple loci,” Genetics Research,
vol. 75, no. 3. Cambridge University Press, pp. 371–373, 2000.
ista: Barton NH. 2000. Population genetics of multiple loci. Genetics Research.
75(3), 371–373.
mla: Barton, Nicholas H. “Population Genetics of Multiple Loci.” Genetics Research,
vol. 75, no. 3, Cambridge University Press, 2000, pp. 371–73, doi:10.1017/S0016672300239220.
short: N.H. Barton, Genetics Research 75 (2000) 371–373.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-18T15:01:01Z
day: '01'
doi: 10.1017/S0016672300239220
extern: '1'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/population-genetics-of-multiple-loci-by-f-b-christiansen-wiley-series-in-mathematical-and-computational-biology-ed-s-levin-john-wiley-sons-1999-isbn-0-471-979791-365-pages-price-80-hardback/9F9E954479B9FB87B0A07250AD6AAD9C
month: '06'
oa_version: None
page: 371 - 373
publication: Genetics Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1814'
quality_controlled: '1'
status: public
title: Population genetics of multiple loci
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...
---
_id: '4433'
abstract:
- lang: eng
text: "Bisimulations enjoy numerous applications in the analysis of labeled transition
systems. Many of these applications are based on two central observations: first,
bisimilar systems satisfy the same branching-time properties; second, bisimilarity
can be checked efficiently for finite-state systems. The local character of bisimulation,
however, makes it difficult to address liveness concerns. Indeed, the definitions
of fair bisimulation that have been proposed in the literature sacrifice locality,
and with it, also efficient checkability. We put forward a new definition of fair
bisimulation which does not suffer from this drawback.\r\nThe bisimilarity of
two systems can be viewed in terms of a game played between a protagonist and
an adversary. In each step of the infinite bisimulation game, the adversary chooses
one system, makes a move, and the protagonist matches it with a move of the other
system. Consistent with this game-based view, we call two fair transition systems
bisimilar if in the bisimulation game, the infinite path produced in the first
system is fair iff the infinite path produced in the second system is fair.\r\nWe
show that this notion of fair bisimulation enjoys the following properties. First,
fairly bisimilar systems satisfy the same formulas of the logics Fair-AFMC (the
fair alternation-free μ-calculus) and Fair-CTL*. Therefore, fair bisimulations
can serve as property-preserving abstractions for these logics and weaker ones,
such as Fair-CTL and LTL. Indeed, Fair-AFMC provides an exact logical characterization
of fair bisimilarity. Second, it can be checked in time polynomial in the number
of states if two systems are fairly bisimilar. This is in stark contrast to all
trace-based equivalences, which are traditionally used for addressing liveness
but require exponential time for checking."
acknowledgement: This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the SRC contract 99-TJ-683.003, the MARCO grant 98-DT-660, the DARPA (MARCO) grant
MDA972-99-1-0001, and the NSF CAREER award CCR-9501708.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: 'Henzinger TA, Rajamani S. Fair bisimulation. In: Proceedings of the 6th
International Conference on Tools and Algorithms for the Construction and Analysis
of Systems. Vol 1785. Springer; 2000:299-314. doi:10.1007/3-540-46419-0_21'
apa: 'Henzinger, T. A., & Rajamani, S. (2000). Fair bisimulation. In Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems (Vol. 1785, pp. 299–314). Berlin, Germany: Springer.
https://doi.org/10.1007/3-540-46419-0_21'
chicago: Henzinger, Thomas A, and Sriram Rajamani. “Fair Bisimulation.” In Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, 1785:299–314. Springer, 2000. https://doi.org/10.1007/3-540-46419-0_21.
ieee: T. A. Henzinger and S. Rajamani, “Fair bisimulation,” in Proceedings of
the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, Berlin, Germany, 2000, vol. 1785, pp. 299–314.
ista: 'Henzinger TA, Rajamani S. 2000. Fair bisimulation. Proceedings of the 6th
International Conference on Tools and Algorithms for the Construction and Analysis
of Systems. TACAS: Tools and Algorithms for the Construction and Analysis of Systems,
LNCS, vol. 1785, 299–314.'
mla: Henzinger, Thomas A., and Sriram Rajamani. “Fair Bisimulation.” Proceedings
of the 6th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, vol. 1785, Springer, 2000, pp. 299–314, doi:10.1007/3-540-46419-0_21.
short: T.A. Henzinger, S. Rajamani, in:, Proceedings of the 6th International Conference
on Tools and Algorithms for the Construction and Analysis of Systems, Springer,
2000, pp. 299–314.
conference:
end_date: 2000-04-02
location: Berlin, Germany
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2000-03-25
date_created: 2018-12-11T12:08:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:11:07Z
day: '01'
doi: 10.1007/3-540-46419-0_21
extern: '1'
intvolume: ' 1785'
language:
- iso: eng
month: '01'
oa_version: None
page: 299 - 314
publication: Proceedings of the 6th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems
publication_identifier:
isbn:
- '9783540672821'
publication_status: published
publisher: Springer
publist_id: '297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair bisimulation
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1785
year: '2000'
...
---
_id: '4434'
abstract:
- lang: eng
text: 'The algorithmic approach to the analysis of timed and hybrid systems is fundamentally
limited by undecidability, of universality in the timed case (where all continuous
variables are clocks), and of emptiness in the rectangular case (which includes
drifting clocks). Traditional proofs of undecidability encode a single Turing
computation by a single timed trajectory. These proofs have nurtured the hope
that the introduction of “fuzziness” into timed and hybrid models (in the sense
that a system cannot distinguish between trajectories that are sufficiently similar)
may lead to decidability. We show that this is not the case, by sharpening both
fundamental undecidability results. Besides the obvious blow our results deal
to the algorithmic method, they also prove that the standard model of timed and
hybrid systems, while not “robust” in its definition of trajectory acceptance
(which is affected by tiny perturbations in the timing of events), is quite robust
in its mathematical properties: the undecidability barriers are not affected by
reasonable perturbations of the model.'
acknowledgement: 'This research was supported in part by the DARPA (NASA) grant NAG2-1214,
the DARPA (Wright-Patterson AFB) grant F33615-C-98-3614, the ARO MURI grant DAAH-04-96-1-0341,
and the NSF CAREER award CCR-9501708. '
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jean
full_name: Raskin, Jean
last_name: Raskin
citation:
ama: 'Henzinger TA, Raskin J. Robust undecidability of timed and hybrid systems.
In: Proceedings of the 3rd International Workshop on Hybrid Systems. Vol
1790. Springer; 2000:145-159. doi:10.1007/3-540-46430-1_15'
apa: 'Henzinger, T. A., & Raskin, J. (2000). Robust undecidability of timed
and hybrid systems. In Proceedings of the 3rd International Workshop on Hybrid
Systems (Vol. 1790, pp. 145–159). Pittsburgh, PA, USA: Springer. https://doi.org/10.1007/3-540-46430-1_15'
chicago: Henzinger, Thomas A, and Jean Raskin. “Robust Undecidability of Timed and
Hybrid Systems.” In Proceedings of the 3rd International Workshop on Hybrid
Systems, 1790:145–59. Springer, 2000. https://doi.org/10.1007/3-540-46430-1_15.
ieee: T. A. Henzinger and J. Raskin, “Robust undecidability of timed and hybrid
systems,” in Proceedings of the 3rd International Workshop on Hybrid Systems,
Pittsburgh, PA, USA, 2000, vol. 1790, pp. 145–159.
ista: 'Henzinger TA, Raskin J. 2000. Robust undecidability of timed and hybrid systems.
Proceedings of the 3rd International Workshop on Hybrid Systems. HSCC: Hybrid
Systems - Computation and Control, LNCS, vol. 1790, 145–159.'
mla: Henzinger, Thomas A., and Jean Raskin. “Robust Undecidability of Timed and
Hybrid Systems.” Proceedings of the 3rd International Workshop on Hybrid Systems,
vol. 1790, Springer, 2000, pp. 145–59, doi:10.1007/3-540-46430-1_15.
short: T.A. Henzinger, J. Raskin, in:, Proceedings of the 3rd International Workshop
on Hybrid Systems, Springer, 2000, pp. 145–159.
conference:
end_date: 2000-03-25
location: Pittsburgh, PA, USA
name: 'HSCC: Hybrid Systems - Computation and Control'
start_date: 2000-03-23
date_created: 2018-12-11T12:08:50Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-04-18T13:16:13Z
day: '01'
doi: 10.1007/3-540-46430-1_15
extern: '1'
intvolume: ' 1790'
language:
- iso: eng
month: '01'
oa_version: None
page: 145 - 159
publication: Proceedings of the 3rd International Workshop on Hybrid Systems
publication_identifier:
isbn:
- '9783540672593'
publication_status: published
publisher: Springer
publist_id: '298'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Robust undecidability of timed and hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1790
year: '2000'
...