---
_id: '2600'
abstract:
- lang: eng
text: 'The synaptic relationship between substance P (SP) and its receptor, i.e.
neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal
subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the
rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry
for NK1 and SP was performed. In electron microscopic double-immunolabeling study,
immunoreactivity for NK1R was detected with the silver-intensified gold method,
while immunoreactivity for SP was detected with peroxidase immunohistochemistry.
SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric)
contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo.
Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive
sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic
and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals
might not only act on NK1Rs facing the SP-containing axon terminals, but also
diffuse in the extracellular fluid for distances larger than the synaptic cleft
to act on NK1Rs at some distances from the synaptic sites. '
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Dan
full_name: Wang, Dan
last_name: Wang
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat. Neuroscience
Research. 2000;36(4):327-334. doi:10.1016/S0168-0102(00)00095-X'
apa: 'Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N.
(2000). The relationship between neurokinin-1 receptor and substance P in the
medullary dorsal horn: A light and electron microscopic immunohistochemical study
in the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(00)00095-X'
chicago: 'Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura,
and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance
P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical
Study in the Rat.” Neuroscience Research. Elsevier, 2000. https://doi.org/10.1016/S0168-0102(00)00095-X.'
ieee: 'J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat,” Neuroscience
Research, vol. 36, no. 4. Elsevier, pp. 327–334, 2000.'
ista: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship
between neurokinin-1 receptor and substance P in the medullary dorsal horn: A
light and electron microscopic immunohistochemical study in the rat. Neuroscience
Research. 36(4), 327–334.'
mla: 'Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance
P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical
Study in the Rat.” Neuroscience Research, vol. 36, no. 4, Elsevier, 2000,
pp. 327–34, doi:10.1016/S0168-0102(00)00095-X.'
short: J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience
Research 36 (2000) 327–334.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-03T10:47:06Z
day: '01'
doi: 10.1016/S0168-0102(00)00095-X
extern: '1'
external_id:
pmid:
- '10771111'
intvolume: ' 36'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 327 - 334
pmid: 1
publication: Neuroscience Research
publication_identifier:
issn:
- 0168-0102
publication_status: published
publisher: Elsevier
publist_id: '4298'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The relationship between neurokinin-1 receptor and substance P in the medullary
dorsal horn: A light and electron microscopic immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 36
year: '2000'
...
---
_id: '2601'
abstract:
- lang: eng
text: Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene
can cause defects in development and function in the cerebellum. We introduced
the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje
cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term
depression and regression of multiple climbing fiber innervation, events significantly
impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by
this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a
key molecule for normal synapse formation, synaptic plasticity, and motor control
in the cerebellum.
article_processing_charge: No
article_type: original
author:
- first_name: Taeko
full_name: Ichise, Taeko
last_name: Ichise
- first_name: Masanobu
full_name: Kano, Masanobu
last_name: Kano
- first_name: Kouichi
full_name: Hashimoto, Kouichi
last_name: Hashimoto
- first_name: Dai
full_name: Yanagihara, Dai
last_name: Yanagihara
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Atsu
full_name: Aiba, Atsu
last_name: Aiba
citation:
ama: Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential
for long-term depression, synapse elimination, and motor coordination. Science.
2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832
apa: Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto,
R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term
depression, synapse elimination, and motor coordination. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832
chicago: Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki
Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar
Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor
Coordination.” Science. American Association for the Advancement of Science,
2000. https://doi.org/10.1126/science.288.5472.1832.
ieee: T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for
long-term depression, synapse elimination, and motor coordination,” Science,
vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835,
2000.
ista: Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki
M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression,
synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.
mla: Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term
Depression, Synapse Elimination, and Motor Coordination.” Science, vol.
288, no. 5472, American Association for the Advancement of Science, 2000, pp.
1832–35, doi:10.1126/science.288.5472.1832.
short: T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto,
M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T09:53:38Z
day: '09'
doi: 10.1126/science.288.5472.1832
extern: '1'
external_id:
pmid:
- '10846166 '
intvolume: ' 288'
issue: '5472'
language:
- iso: eng
month: '06'
oa_version: None
page: 1832 - 1835
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse
elimination, and motor coordination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 288
year: '2000'
...
---
_id: '2602'
abstract:
- lang: eng
text: Although presynaptic localization of mGluR7 is well established, the mechanism
by which the receptor may control Ca2+ channels in neurons is still unknown. We
show here that cultured cerebellar granule cells express native metabotropic glutamate
receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was
also expressed in cell bodies. This allowed us to study the effect of the transfected
receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited
P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis
toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating
the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics
of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel
subunit, but was abolished by quenching βγ subunits with specific intracellular
peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action
of mGluR7, suggesting that both G-protein βγ and αo subunits were required to
mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory
action of mGluR7, suggesting that a coincident activation of PLC by the G-protein
βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition
of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC)
abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent
IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release
was required for PKC-dependent inhibition of the Ca2+ channels. Possible control
of synaptic transmission by the present mechanisms is discussed.
acknowledgement: This work was supported by Centre National de la Recherche Scientifique
and grants from Association Française contre les Myopathies, Fondation pour la Recherche
Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J.
P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J.
Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France)
for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the
anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal
antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Prezèau, Laurent
last_name: Prezèau
- first_name: Michel
full_name: De Waard, Michel
last_name: De Waard
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Joël
full_name: Bockaërt, Joël
last_name: Bockaërt
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
citation:
ama: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience.
2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000
apa: Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni,
L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic
glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000
chicago: Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël
Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels
by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway
in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.
ieee: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni,
“Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons,” Journal of
Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.
ista: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21),
7896–7904.
mla: Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the
Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.”
Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000,
pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.
short: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni,
Journal of Neuroscience 20 (2000) 7896–7904.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:48:17Z
day: '01'
doi: 10.1523/JNEUROSCI.20-21-07896.2000
extern: '1'
external_id:
pmid:
- '11050109'
intvolume: ' 20'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/
month: '11'
oa: 1
oa_version: Published Version
page: 7896 - 7904
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4296'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '2603'
abstract:
- lang: eng
text: Aggregation of neurotransmitter receptors at pre- and postsynaptic structures
is crucial for efficient neuronal communication. In contrast to the wealth of
information about postsynaptic specializations, little is known about the molecular
organization of presynaptic membrane proteins. We show here that the metabotropic
glutamate receptor mGluR7a, which localizes specifically to presynaptic active
zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous
systems induces coclustering dependent upon the extreme C terminus of mGluR7a
and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses
in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic
sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not
cluster. These results suggest that PICK1 is a component of the presynaptic machinery
involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.
acknowledgement: 'We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P.
J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent
preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work
was supported by the Pew Chari-table Trust and National Institutes of Health grants
NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship
from IPSEN Foundation (H. B.). '
article_processing_charge: No
article_type: original
author:
- first_name: Hélène
full_name: Boudin, Hélène
last_name: Boudin
- first_name: Andrew
full_name: Doan, Andrew
last_name: Doan
- first_name: Jun
full_name: Xia, Jun
last_name: Xia
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Richard
full_name: Huganir, Richard
last_name: Huganir
- first_name: Paul
full_name: Worley, Paul
last_name: Worley
- first_name: Ann
full_name: Craig, Ann
last_name: Craig
citation:
ama: Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires
the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6
apa: Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., &
Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain
binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6
chicago: Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir,
Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1
PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6.
ieee: H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1
PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497,
2000.
ista: Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000.
Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site.
Neuron. 28(2), 485–497.
mla: Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1
PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97,
doi:10.1016/S0896-6273(00)00127-6.
short: H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig,
Neuron 28 (2000) 485–497.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:41:55Z
day: '01'
doi: 10.1016/S0896-6273(00)00127-6
extern: '1'
external_id:
pmid:
- '11144358'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 485 - 497
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4295'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '2710'
abstract:
- lang: eng
text: In this paper we describe an intrinsically geometric way of producing magnetic
fields on §3 and $\R^3$ for which the corresponding Dirac operators have a non-trivial
kernel. In many cases we are able to compute the dimension of the kernel. In particular
we can give examples where the kernel has any given dimension. This generalizes
the examples of Loss and Yau (Commun. Math. Phys. 104 (1986) 283-290).
acknowledgement: L. Erdös was supported by the N.S.F. grant DMS-9970323. J. P. Solovej
was supported in parts by the EU TMR-grant FMRX-CT 96-0001 by MaPhySto — Centre
for Mathematical Physics and Stochastics, funded by a grant from The Danish National
Research Foundation and by a grant from the Danish Natural Science Research Council.
alternative_title:
- AMS/IP Studies in Advanced Mathematics
article_processing_charge: No
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. The kernel of Dirac operators on S3 and R3. In: Differential Equations
and Mathematical Physics. Vol 16. American Mathematical Society; 2000:111-119.
doi:10.1090/amsip/016'
apa: Erdös, L. (2000). The kernel of Dirac operators on S3 and R3. In Differential
Equations and Mathematical Physics (Vol. 16, pp. 111–119). American Mathematical
Society. https://doi.org/10.1090/amsip/016
chicago: Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” In Differential
Equations and Mathematical Physics, 16:111–19. American Mathematical Society,
2000. https://doi.org/10.1090/amsip/016.
ieee: L. Erdös, “The kernel of Dirac operators on S3 and R3,” in Differential
Equations and Mathematical Physics, vol. 16, American Mathematical Society,
2000, pp. 111–119.
ista: 'Erdös L. 2000.The kernel of Dirac operators on S3 and R3. In: Differential
Equations and Mathematical Physics. AMS/IP Studies in Advanced Mathematics, vol.
16, 111–119.'
mla: Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” Differential
Equations and Mathematical Physics, vol. 16, American Mathematical Society,
2000, pp. 111–19, doi:10.1090/amsip/016.
short: L. Erdös, in:, Differential Equations and Mathematical Physics, American
Mathematical Society, 2000, pp. 111–119.
date_created: 2018-12-11T11:59:12Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T09:37:03Z
day: '01'
doi: 10.1090/amsip/016
extern: '1'
external_id:
arxiv:
- math-ph/0001036
intvolume: ' 16'
language:
- iso: eng
month: '01'
oa_version: Preprint
page: 111 - 119
publication: Differential Equations and Mathematical Physics
publication_identifier:
isbn:
- '9780821821572'
publication_status: published
publisher: American Mathematical Society
publist_id: '4186'
quality_controlled: '1'
status: public
title: The kernel of Dirac operators on S3 and R3
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2000'
...
---
_id: '2731'
abstract:
- lang: eng
text: We study the time evolution of a quantum particle in a Gaussian random environment.
We show that in the weak coupling limit the Wigner distribution of the wave function
converges to a solution of a linear Boltzmann equation globally in time. The Boltzmann
collision kernel is given by the Born approximation of the quantum differential
scattering cross section.
acknowledgement: Partially supported by U.S. National Science Foundation grants DMS-9403462,
9703752. We would like to thank H. Spohn for his several comments and discussions
on this project. Part of this work was done during the time when L. E. visited the
Erwin Schrödinger Institute in Vienna and when both authors visited the Center of
Theoretical Sciences in Taiwan. We thank them for the hospitality and the support
of this work.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Linear Boltzmann equation as the weak coupling limit of a random
Schrödinger equation. Communications on Pure and Applied Mathematics. 2000;53(6):667-735.
doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
apa: Erdös, L., & Yau, H. (2000). Linear Boltzmann equation as the weak coupling
limit of a random Schrödinger equation. Communications on Pure and Applied
Mathematics. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
chicago: Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling
Limit of a Random Schrödinger Equation.” Communications on Pure and Applied
Mathematics. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5.
ieee: L. Erdös and H. Yau, “Linear Boltzmann equation as the weak coupling limit
of a random Schrödinger equation,” Communications on Pure and Applied Mathematics,
vol. 53, no. 6. Wiley-Blackwell, pp. 667–735, 2000.
ista: Erdös L, Yau H. 2000. Linear Boltzmann equation as the weak coupling limit
of a random Schrödinger equation. Communications on Pure and Applied Mathematics.
53(6), 667–735.
mla: Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling
Limit of a Random Schrödinger Equation.” Communications on Pure and Applied
Mathematics, vol. 53, no. 6, Wiley-Blackwell, 2000, pp. 667–735, doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5.
short: L. Erdös, H. Yau, Communications on Pure and Applied Mathematics 53 (2000)
667–735.
date_created: 2018-12-11T11:59:18Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-03T09:09:04Z
day: '01'
doi: 10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5
extern: '1'
external_id:
arxiv:
- math-ph/9901020
intvolume: ' 53'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: Preprint
page: 667 - 735
publication: Communications on Pure and Applied Mathematics
publication_identifier:
issn:
- 0010-3640
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4161'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linear Boltzmann equation as the weak coupling limit of a random Schrödinger
equation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 53
year: '2000'
...
---
_id: '2732'
abstract:
- lang: eng
text: 'We consider a quantum particle moving in a harmonic exterior potential and
linearly coupled to a heat bath of quantum oscillators. Caldeira and Leggett derived
the Fokker Planck equation with friction for the Wigner distribution of the particle
in the large-temperature limit: however, their (nonrigorous) derivation was not
free of criticism, especially since the limiting equation is not of Lindblad form.
In this paper we recover the correct form of their result in a rigorous way. We
also point out that the source of the diffusion is physically restrictive under
this scaling. We investigate the model at a fixed temperature and in the large-time
limit, where the origin of the diffusion is a cumulative effect of many resonant
collisions. We obtain a heat equation with a friction term for the radial process
in phase space and we prove the Einstein relation in this case.'
acknowledgement: The authors are indebted to H. Spohn for discussions. F.C. and L.E.
were partially supported by the Erwin Schrödinger Institute in Vienna (Austria)
during their visit, and they thank this institution for its hospitality. This work
was supported by the TMR-Network ``Asymptotic Methods in Kinetic Theory'' number
ERB FMBX CT97 0157 (F.C., F.F., and P.A.M.) and by NSF Grant DMS-9970323 (L.E.).
article_processing_charge: No
article_type: original
author:
- first_name: François
full_name: Castella, François
last_name: Castella
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Florian
full_name: Frommlet, Florian
last_name: Frommlet
- first_name: Peter
full_name: Markowich, Peter
last_name: Markowich
citation:
ama: Castella F, Erdös L, Frommlet F, Markowich P. Fokker-Planck equations as scaling
limits of reversible quantum systems. Journal of Statistical Physics. 2000;100(3-4):543-601.
doi:10.1023/A:1018667323830
apa: Castella, F., Erdös, L., Frommlet, F., & Markowich, P. (2000). Fokker-Planck
equations as scaling limits of reversible quantum systems. Journal of Statistical
Physics. Springer. https://doi.org/10.1023/A:1018667323830
chicago: Castella, François, László Erdös, Florian Frommlet, and Peter Markowich.
“Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal
of Statistical Physics. Springer, 2000. https://doi.org/10.1023/A:1018667323830.
ieee: F. Castella, L. Erdös, F. Frommlet, and P. Markowich, “Fokker-Planck equations
as scaling limits of reversible quantum systems,” Journal of Statistical Physics,
vol. 100, no. 3–4. Springer, pp. 543–601, 2000.
ista: Castella F, Erdös L, Frommlet F, Markowich P. 2000. Fokker-Planck equations
as scaling limits of reversible quantum systems. Journal of Statistical Physics.
100(3–4), 543–601.
mla: Castella, François, et al. “Fokker-Planck Equations as Scaling Limits of Reversible
Quantum Systems.” Journal of Statistical Physics, vol. 100, no. 3–4, Springer,
2000, pp. 543–601, doi:10.1023/A:1018667323830.
short: F. Castella, L. Erdös, F. Frommlet, P. Markowich, Journal of Statistical
Physics 100 (2000) 543–601.
date_created: 2018-12-11T11:59:18Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T09:02:11Z
day: '01'
doi: 10.1023/A:1018667323830
extern: '1'
intvolume: ' 100'
issue: 3-4
language:
- iso: eng
month: '01'
oa_version: None
page: 543 - 601
publication: Journal of Statistical Physics
publication_identifier:
issn:
- 0022-4715
publication_status: published
publisher: Springer
publist_id: '4160'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fokker-Planck equations as scaling limits of reversible quantum systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 100
year: '2000'
...
---
_id: '2733'
abstract:
- lang: eng
text: The Li-Yau semiclassical lower bound for the sum of the first N eigenvalues
of the Dirichlet–Laplacian is extended to Dirichlet–Laplacians with constant magnetic
fields. Our method involves a new diamagnetic inequality for constant magnetic
fields.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Michael
full_name: Loss, Michael
last_name: Loss
- first_name: Vitali
full_name: Vougalter, Vitali
last_name: Vougalter
citation:
ama: Erdös L, Loss M, Vougalter V. Diamagnetic behavior of sums Dirichlet eigenvalues.
Annales de l’Institut Fourier. 2000;50(3):891-907. doi:10.5802/aif.1777
apa: Erdös, L., Loss, M., & Vougalter, V. (2000). Diamagnetic behavior of sums
Dirichlet eigenvalues. Annales de l’Institut Fourier. Association des Annales
de l’Institut Fourier. https://doi.org/10.5802/aif.1777
chicago: Erdös, László, Michael Loss, and Vitali Vougalter. “Diamagnetic Behavior
of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier. Association
des Annales de l’Institut Fourier, 2000. https://doi.org/10.5802/aif.1777.
ieee: L. Erdös, M. Loss, and V. Vougalter, “Diamagnetic behavior of sums Dirichlet
eigenvalues,” Annales de l’Institut Fourier, vol. 50, no. 3. Association
des Annales de l’Institut Fourier, pp. 891–907, 2000.
ista: Erdös L, Loss M, Vougalter V. 2000. Diamagnetic behavior of sums Dirichlet
eigenvalues. Annales de l’Institut Fourier. 50(3), 891–907.
mla: Erdös, László, et al. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.”
Annales de l’Institut Fourier, vol. 50, no. 3, Association des Annales
de l’Institut Fourier, 2000, pp. 891–907, doi:10.5802/aif.1777.
short: L. Erdös, M. Loss, V. Vougalter, Annales de l’Institut Fourier 50 (2000)
891–907.
date_created: 2018-12-11T11:59:19Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T08:56:17Z
day: '01'
doi: 10.5802/aif.1777
extern: '1'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 891 - 907
publication: Annales de l'Institut Fourier
publication_identifier:
issn:
- 0373-0956
publication_status: published
publisher: Association des Annales de l'Institut Fourier
publist_id: '4159'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diamagnetic behavior of sums Dirichlet eigenvalues
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '2000'
...
---
_id: '3149'
abstract:
- lang: eng
text: The prohormone convertases (PCs) are an evolutionarily ancient group of proteases
required for the maturation of neuropeptide and peptide hormone precursors. In
Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado),
is required for normal hatching behavior, and immunoblotting data indicate that
flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires
7B2, a helper protein for productive maturation, we searched the fly data base
for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone
encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were
subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and
rat 7B2 were used as controls. Although active mPC2 was detected in medium in
the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon
coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was
synthesized but not secreted from HEK-293 cells. However, when dPC2 and either
d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive
dPC2 was secreted into the medium, coincident with the appearance of PC2 activity.
Expression and secretion of dPC2 enzyme activity thus appears to require insect
cell-specific posttranslational processing events. The significant differences
in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required
for secretion of dPC2 and zymogen conversion occurring intracellularly in the
case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific
requirements for maturation and secretion that can be met only in insect cells.
acknowledgement: This work was supported by National Institutes of Health Grants DK49703
(to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section
1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory
and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans
PC2 expression vector, and Joelle Finley for assistance with cell culture.
article_processing_charge: No
article_type: original
author:
- first_name: Jae
full_name: Hwang, Jae
last_name: Hwang
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
- first_name: Paul
full_name: Taghert, Paul
last_name: Taghert
- first_name: Iris
full_name: Lindberg, Iris
last_name: Lindberg
citation:
ama: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila
melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing
and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893.
doi:10.1074/jbc.M000032200 '
apa: 'Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000).
Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 '
chicago: 'Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg.
“Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect
Cell Specific Processing and Secretion.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .'
ieee: 'J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion,” Journal of Biological Chemistry, vol. 275, no.
23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893,
2000.'
ista: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.'
mla: 'Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase
2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological
Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular
Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .'
short: J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological
Chemistry 275 (2000) 17886–17893.
date_created: 2018-12-11T12:01:40Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T08:47:13Z
day: '09'
doi: '10.1074/jbc.M000032200 '
extern: '1'
external_id:
pmid:
- '10749852'
intvolume: ' 275'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 17886 - 17893
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '3546'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 275
year: '2000'
...
---
_id: '3489'
abstract:
- lang: eng
text: We have examined factors that determine the strength and dynamics of GABAergic
synapses between interneurons [dentate gyrus basket cells (BCs)] and principal
neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal
slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular
Cl− concentration showed a fast rise and a biexponential decay, with mean time
constants of 2 and 9 msec. The mean quantal conductance change, determined directly
at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release
at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis
of IPSC peak amplitudes and numbers of failures by multiple probability compound
binomial analysis indicated that synaptic transmission at the BC–GC synapse involves
three to seven release sites, each of which releases transmitter with high probability
(∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression
(PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery
from depression occurred with a time constant of 2 sec. Paired-pulse depression
was mainly presynaptic in origin but appeared to be independent of previous release.
Synaptic transmission at the BC–GC synapse showed frequency-dependent depression,
with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials.
The relative stability of transmission at the BC–GC synapse is consistent with
a model in which an activity-dependent gating mechanism reduces release probability
and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus
several mechanisms converge on the generation of powerful and sustained transmission
at interneuron–principal neuron synapses in hippocampal circuits.
acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft
(SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B)
to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger,
F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically
reading this manuscript. We also thank A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a
hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000
apa: Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal
GABA release at a hippocampal interneuron-principal neuron synapse. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000
chicago: Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.
ieee: U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience,
vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.
ista: Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
20(15), 5594–5607.
mla: Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607,
doi:10.1523/JNEUROSCI.20-15-05594.2000.
short: U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-08-01T00:00:00Z
date_updated: 2023-05-03T08:18:39Z
day: '01'
doi: 10.1523/JNEUROSCI.20-15-05594.2000
extern: '1'
external_id:
pmid:
- '10908596'
intvolume: ' 20'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/
month: '08'
oa: 1
oa_version: Published Version
page: 5594 - 5607
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2898'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal
neuron synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3490'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that can be induced
either by low-frequency stimulation of presynaptic fibers or in an associative
manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated
the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus
using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices.
Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with
a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude
to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant
to the application of D-AP-5, indicating that it is independent of NMDA receptors.
In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine,
indicating the involvement of metabotropic glutamate receptors. Furthermore, associative
LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic
action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin
GVIA, a selective N-type channel blocker, abolished the induction of associative
LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist,
inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting
presynaptic transmitter release. OH-DPAT also inhibited the induction of associative
LTD, suggesting that the involvement of N-type channels makes synaptic plasticity
accessible to modulation by neurotransmitters. Thus, the modulation of N-type
Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal
neurons.
acknowledgement: This work was supported by a grant from the Deutsche Forschungsgemeinschaft
Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation
(J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically
reading this manuscript and A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Claus
full_name: Normann, Claus
last_name: Normann
- first_name: Diana
full_name: Peckys, Diana
last_name: Peckys
- first_name: Christian
full_name: Schulze, Christian
last_name: Schulze
- first_name: Jörg
full_name: Walden, Jörg
last_name: Walden
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
citation:
ama: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative
long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+)
channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000
apa: Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger,
J. (2000). Associative long-term depression in the hippocampus is dependent on
postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000
chicago: Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas,
and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience.
Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.
ieee: C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger,
“Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society
for Neuroscience, pp. 8290–8297, 2000.
ista: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000.
Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.
mla: Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience,
vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000.
short: C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger,
Journal of Neuroscience 20 (2000) 8290–8297.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-11-15T00:00:00Z
date_updated: 2023-05-03T08:02:52Z
day: '15'
doi: 10.1523/JNEUROSCI.20-22-08290.2000
extern: '1'
external_id:
pmid:
- '11069935'
intvolume: ' 20'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/
month: '11'
oa: 1
oa_version: Published Version
page: 8290 - 8297
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2897'
quality_controlled: '1'
status: public
title: Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3491'
abstract:
- lang: eng
text: Fast and reliable activation of inhibitory interneurons is critical for the
stability of cortical neuronal networks. Active conductances in dendrites may
facilitate interneuron activation, but direct experimental evidence was unavailable.
Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons
revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous
recordings from dendrites and somata suggested that action potential initiation
occurs preferentially in the axon with long threshold stimuli, but can be shifted
to somatodendritic sites when brief stimuli are applied. After initiation, action
potentials propagate over the somatodendritic domain with constant amplitude,
high velocity, and reliability, even during high-frequency trains.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action
potentials in interneuron dendrites. Science. 2000;287(5451):295-300. doi:10.1126/science.287.5451.295
apa: Martina, M., Vida, I., & Jonas, P. M. (2000). Distal initiation and active
propagation of action potentials in interneuron dendrites. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.287.5451.295
chicago: Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active
Propagation of Action Potentials in Interneuron Dendrites.” Science. American
Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.287.5451.295.
ieee: M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation
of action potentials in interneuron dendrites,” Science, vol. 287, no.
5451. American Association for the Advancement of Science, pp. 295–300, 2000.
ista: Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation
of action potentials in interneuron dendrites. Science. 287(5451), 295–300.
mla: Martina, Marco, et al. “Distal Initiation and Active Propagation of Action
Potentials in Interneuron Dendrites.” Science, vol. 287, no. 5451, American
Association for the Advancement of Science, 2000, pp. 295–300, doi:10.1126/science.287.5451.295.
short: M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-01-14T00:00:00Z
date_updated: 2023-05-03T07:55:32Z
day: '14'
doi: 10.1126/science.287.5451.295
extern: '1'
external_id:
pmid:
- '10634782'
intvolume: ' 287'
issue: '5451'
language:
- iso: eng
month: '01'
oa_version: None
page: 295 - 300
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distal initiation and active propagation of action potentials in interneuron
dendrites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 287
year: '2000'
...
---
_id: '3492'
abstract:
- lang: eng
text: Analysis of presynaptic determinants of synaptic strength has been difficult
at cortical synapses, mainly due to the lack of direct access to presynaptic elements.
Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal
slices. The presynaptic action potential is very short during low-frequency stimulation
but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated
K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly,
suggesting that cumulative K+ channel inactivation mediates activity-dependent
spike broadening. Prolongation of the presynaptic voltage waveform leads to an
increase in the number of Ca2+ ions entering the terminal per action potential
and to a consecutive potentiation of evoked excitatory postsynaptic currents at
MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels
contributes to the control of efficacy of a glutamatergic synapse in the cortex.
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating
K+ channels in hippocampal mossy fiber boutons. Neuron. 2000;28(3):927-939.
doi:10.1016/S0896-6273(00)00164-1
apa: Geiger, J., & Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+)
inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron.
Elsevier. https://doi.org/10.1016/S0896-6273(00)00164-1
chicago: Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+)
Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron.
Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00164-1.
ieee: J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by
fast-inactivating K+ channels in hippocampal mossy fiber boutons,” Neuron,
vol. 28, no. 3. Elsevier, pp. 927–939, 2000.
ista: Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by
fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3),
927–939.
mla: Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow
by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron,
vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:10.1016/S0896-6273(00)00164-1.
short: J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.
date_created: 2018-12-11T12:03:37Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-05-02T14:34:37Z
day: '01'
doi: 10.1016/S0896-6273(00)00164-1
extern: '1'
external_id:
pmid:
- '11163277'
intvolume: ' 28'
issue: '3'
language:
- iso: eng
month: '12'
oa_version: None
page: 927 - 939
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2895'
quality_controlled: '1'
status: public
title: Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels
in hippocampal mossy fiber boutons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '3532'
abstract:
- lang: eng
text: Multichannel tetrode array recording in awake behaving animals provides a
powerful method to record the activity of large numbers of neurons. The power
of this method could be extended if further information concerning the intracellular
state of the neurons could be extracted from the extracellularly recorded signals.
Toward this end, we have simultaneously recorded intracellular and extracellular
signals from hippocampal CA1 pyramidal cells and interneurons in the anesthetized
rat. We found that several intracellular parameters can be deduced from extracellular
spike waveforms. The width of the intracellular action potential is defined precisely
by distinct points on the extracellular spike. Amplitude changes of the intracellular
action potential are reflected by changes in the amplitude of the initial negative
phase of the extracellular spike, and these amplitude changes are dependent on
the state of the network. In addition, intracellular recordings from dendrites
with simultaneous extracellular recordings from the soma indicate that, on average,
action potentials are initiated in the perisomatic region and propagate to the
dendrites at 1.68 m/s. Finally we determined that a tetrode in hippocampal area
CA1 theoretically should be able to record electrical signals from similar to
1,000 neurons. Of these, 60-100 neurons should generate spikes of sufficient amplitude
to be detectable from the noise and to allow for their separation using current
spatial clustering methods. This theoretical maximum is in contrast to the approximately
six units that are usually detected per tetrode. From this, we conclude that a
large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral
condition.
acknowledgement: We thank M. Recce for comments on the manuscript and J. Hetke and
K.Wise for supplying us with the silicon probes (1P41RR09754).This work was supported
by National Institutes of Health Grants NS-34994,MH-54671, and MH-12403 (to D.
A. Henze), the Epilepsy Foundation of American (D. A.Henze), and an Eotvos fellowship
(Z. Borhegyi).
article_processing_charge: No
article_type: original
author:
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Zsolt
full_name: Borhegyi, Zsolt
last_name: Borhegyi
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 2000;84(1):390-400. doi:10.1152/jn.2000.84.1.390
apa: Henze, D., Borhegyi, Z., Csicsvari, J. L., Mamiya, A., Harris, K., & Buzsáki,
G. (2000). Intracellular features predicted by extracellular recordings in the
hippocampus in vivo. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.390
chicago: Henze, Darrell, Zsolt Borhegyi, Jozsef L Csicsvari, Akira Mamiya, Kenneth
Harris, and György Buzsáki. “Intracellular Features Predicted by Extracellular
Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology. American
Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.390.
ieee: D. Henze, Z. Borhegyi, J. L. Csicsvari, A. Mamiya, K. Harris, and G. Buzsáki,
“Intracellular features predicted by extracellular recordings in the hippocampus
in vivo,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 390–400, 2000.
ista: Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. 2000. Intracellular
features predicted by extracellular recordings in the hippocampus in vivo. Journal
of Neurophysiology. 84(1), 390–400.
mla: Henze, Darrell, et al. “Intracellular Features Predicted by Extracellular Recordings
in the Hippocampus in Vivo.” Journal of Neurophysiology, vol. 84, no. 1,
American Physiological Society, 2000, pp. 390–400, doi:10.1152/jn.2000.84.1.390.
short: D. Henze, Z. Borhegyi, J.L. Csicsvari, A. Mamiya, K. Harris, G. Buzsáki,
Journal of Neurophysiology 84 (2000) 390–400.
date_created: 2018-12-11T12:03:49Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:31:13Z
day: '01'
doi: 10.1152/jn.2000.84.1.390
extern: '1'
external_id:
pmid:
- '10899213'
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 390 - 400
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2854'
quality_controlled: '1'
status: public
title: Intracellular features predicted by extracellular recordings in the hippocampus
in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3542'
abstract:
- lang: eng
text: Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous
recording of neuronal ensembles in the behaving rat. A nonlinear interaction among
pyramidal neurons was observed during sharp wave (SPW)-related population bursts,
with stronger synchrony associated with more widespread spatial coherence. SPW
bursts emerged in the CA3a-b subregions and spread to CA3c before invading the
CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was
required to exert a detectable influence on CA1 pyramidal cells. Activity of some
CA3 pyramidal neurons differentially predicted the ripple-related discharge of
circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral
state, the coherent discharge of a small group of CA3 cells is the primary cause
of spiking activity in CA1 pyramidal neurons.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron.
2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5
apa: Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble
patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population
events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5
chicago: Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble
Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population
Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5.
ieee: J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns
of hippocampal CA3-CA1 neurons during sharp wave-associated population events,”
Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000.
ista: Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal
CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2),
585–594.
mla: Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons
during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2,
Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5.
short: J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594.
date_created: 2018-12-11T12:03:52Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-02T14:26:07Z
day: '01'
doi: 10.1016/S0896-6273(00)00135-5
extern: '1'
intvolume: ' 28'
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 585 - 594
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '2843'
quality_controlled: '1'
status: public
title: Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated
population events
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2000'
...
---
_id: '3548'
abstract:
- lang: eng
text: Simultaneous recording from large numbers of neurons is a prerequisite for
understanding their cooperative behavior. Various recording techniques and spike
separation methods are being used toward this goal. However, the error rates involved
in spike separation have not yet been quantified. We studied the separation reliability
of “tetrode” (4-wire electrode) recorded spikes by monitoring simultaneously from
the same cell intracellularly with a glass pipette and extracellularly with a
tetrode. With manual spike sorting, we found a trade-off between Type I and Type
II errors, with errors typically ranging from 0 to 30% depending on the amplitude
and firing pattern of the cell, the similarity of the waveshapes of neighboring
neurons, and the experience of the operator. Performance using only a single wire
was markedly lower, indicating the advantages of multiple-site monitoring techniques
over single-wire recordings. For tetrode recordings, error rates were increased
by burst activity and during periods of cellular synchrony. The lowest possible
separation error rates were estimated by a search for the best ellipsoidal cluster
shape. Human operator performance was significantly below the estimated optimum.
Investigation of error distributions indicated that suboptimal performance was
caused by inability of the operators to mark cluster boundaries accurately in
a high-dimensional feature space. We therefore hypothesized that automatic spike-sorting
algorithms have the potential to significantly lower error rates. Implementation
of a semi-automatic classification system confirms this suggestion, reducing errors
close to the estimated optimum, in the range 0-8%.
acknowledgement: The costs of publication of this article were defrayed in part by
the payment of page charges. The article must therefore be hereby marked ‘‘advertisement’
’in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank
R. Bruno for performing cluster analysis and drawing our attention to the AutoClass
program, M. Recce and P. Mitra for suggestions withdata analysis and comments on
the manuscript, C. King, G. Dragoi, and X.Leinekugel for performing cluster analysis,
and J. Hetke and K. Wise for supplying silicon probes. The data used in this paper
are available on request by e-mail to G. Buzsaki. This work was supported by National
Institutes of Health Grants NS-34994,413 MH-54671, and MH-12403 (to D. A. Henze)
and by the Epilepsy Foundationof America (to D. A. Henze).
article_processing_charge: No
article_type: original
author:
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: Darrell
full_name: Henze, Darrell
last_name: Henze
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. Accuracy of tetrode spike
separation as determined by simultaneous intracellular and extracellular measurements.
Journal of Neurophysiology. 2000;84(1):401-414. doi:10.1152/jn.2000.84.1.401
apa: Harris, K., Henze, D., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000).
Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements. Journal of Neurophysiology. American Physiological
Society. https://doi.org/10.1152/jn.2000.84.1.401
chicago: Harris, Kenneth, Darrell Henze, Jozsef L Csicsvari, Hajima Hirase, and
György Buzsáki. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous
Intracellular and Extracellular Measurements.” Journal of Neurophysiology.
American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.401.
ieee: K. Harris, D. Henze, J. L. Csicsvari, H. Hirase, and G. Buzsáki, “Accuracy
of tetrode spike separation as determined by simultaneous intracellular and extracellular
measurements,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological
Society, pp. 401–414, 2000.
ista: Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. 2000. Accuracy of tetrode
spike separation as determined by simultaneous intracellular and extracellular
measurements. Journal of Neurophysiology. 84(1), 401–414.
mla: Harris, Kenneth, et al. “Accuracy of Tetrode Spike Separation as Determined
by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology,
vol. 84, no. 1, American Physiological Society, 2000, pp. 401–14, doi:10.1152/jn.2000.84.1.401.
short: K. Harris, D. Henze, J.L. Csicsvari, H. Hirase, G. Buzsáki, Journal of Neurophysiology
84 (2000) 401–414.
date_created: 2018-12-11T12:03:54Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-05-02T14:16:45Z
day: '01'
doi: 10.1152/jn.2000.84.1.401
extern: '1'
external_id:
pmid:
- '10899214 '
intvolume: ' 84'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 401 - 414
pmid: 1
publication: Journal of Neurophysiology
publication_identifier:
issn:
- 0022-3077
publication_status: published
publisher: American Physiological Society
publist_id: '2837'
quality_controlled: '1'
status: public
title: Accuracy of tetrode spike separation as determined by simultaneous intracellular
and extracellular measurements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '3555'
abstract:
- lang: eng
text: A sliver is a tetrahedron whose four vertices lie close to a plane and whose
perpendicular projection to that plane is a convex quadrilateral with no short
edge. Slivers are both undesirable and ubiquitous in 3-dimensional Delaunay triangulations.
Even when the point-set is well-spaced, slivers may result. This paper shows that
such a point set permits a small perturbation whose Delaunay triangulation contains
no slivers. It also gives deterministic algorithms that compute the perturbation
of n points in time O(n log n) with one processor and in time O(log n) with O(n)
processors.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Xiang
full_name: Li, Xiang
id: 4B7E523C-F248-11E8-B48F-1D18A9856A87
last_name: Li
- first_name: Gary
full_name: Miller, Gary
last_name: Miller
- first_name: Andreas
full_name: Stathopoulos, Andreas
last_name: Stathopoulos
- first_name: Dafna
full_name: Talmor, Dafna
last_name: Talmor
- first_name: Shang
full_name: Teng, Shang
last_name: Teng
- first_name: Alper
full_name: Üngör, Alper
last_name: Üngör
- first_name: Noel
full_name: Walkington, Noel
last_name: Walkington
citation:
ama: 'Edelsbrunner H, Li X, Miller G, et al. Smoothing and cleaning up slivers.
In: Proceedings of the 32nd Annual ACM Symposium on Theory of Computing.
ACM; 2000:273-277. doi:10.1145/335305.335338'
apa: 'Edelsbrunner, H., Li, X., Miller, G., Stathopoulos, A., Talmor, D., Teng,
S., … Walkington, N. (2000). Smoothing and cleaning up slivers. In Proceedings
of the 32nd annual ACM symposium on Theory of computing (pp. 273–277). Portland,
OR, USA: ACM. https://doi.org/10.1145/335305.335338'
chicago: Edelsbrunner, Herbert, Xiang Li, Gary Miller, Andreas Stathopoulos, Dafna
Talmor, Shang Teng, Alper Üngör, and Noel Walkington. “Smoothing and Cleaning
up Slivers.” In Proceedings of the 32nd Annual ACM Symposium on Theory of Computing,
273–77. ACM, 2000. https://doi.org/10.1145/335305.335338.
ieee: H. Edelsbrunner et al., “Smoothing and cleaning up slivers,” in Proceedings
of the 32nd annual ACM symposium on Theory of computing, Portland, OR, USA,
2000, pp. 273–277.
ista: 'Edelsbrunner H, Li X, Miller G, Stathopoulos A, Talmor D, Teng S, Üngör A,
Walkington N. 2000. Smoothing and cleaning up slivers. Proceedings of the 32nd
annual ACM symposium on Theory of computing. STOC: Symposium on the Theory of
Computing, 273–277.'
mla: Edelsbrunner, Herbert, et al. “Smoothing and Cleaning up Slivers.” Proceedings
of the 32nd Annual ACM Symposium on Theory of Computing, ACM, 2000, pp. 273–77,
doi:10.1145/335305.335338.
short: H. Edelsbrunner, X. Li, G. Miller, A. Stathopoulos, D. Talmor, S. Teng, A.
Üngör, N. Walkington, in:, Proceedings of the 32nd Annual ACM Symposium on Theory
of Computing, ACM, 2000, pp. 273–277.
conference:
end_date: 2000-05-23
location: Portland, OR, USA
name: 'STOC: Symposium on the Theory of Computing'
start_date: 2000-05-21
date_created: 2018-12-11T12:03:56Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-02T14:07:00Z
day: '01'
doi: 10.1145/335305.335338
extern: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 273 - 277
publication: Proceedings of the 32nd annual ACM symposium on Theory of computing
publication_identifier:
isbn:
- '9781581131840'
publication_status: published
publisher: ACM
publist_id: '2830'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Smoothing and cleaning up slivers
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '3572'
abstract:
- lang: eng
text: "Allzulange wurde die spielhafte Beschäftigung als Gegensatz zu ernsthafter
Arbeit gesehen. Dieser Artikel propagiert die spielerische Untersuchung von Kreis-
und Kugelmengen. Gleichzeitig belegt er die nutzbare Anwendung\r\nvon elementaren
Einsichten in der Molekularbiologie und allgemeiner\r\nin der Beschreibung von
Form und Verformung."
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung.
In: Zur Kunst Des Formalen Denkens. Passagen Verlag; 2000:153-171.'
apa: Edelsbrunner, H. (2000). Spielereien mit Kreisen und Kugeln. Zum Thema Form
und Verformung. In Zur Kunst des formalen Denkens (pp. 153–171). Passagen
Verlag.
chicago: Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form
Und Verformung.” In Zur Kunst Des Formalen Denkens, 153–71. Passagen Verlag,
2000.
ieee: H. Edelsbrunner, “Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung,”
in Zur Kunst des formalen Denkens, Passagen Verlag, 2000, pp. 153–171.
ista: 'Edelsbrunner H. 2000.Spielereien mit Kreisen und Kugeln. Zum Thema Form und
Verformung. In: Zur Kunst des formalen Denkens. , 153–171.'
mla: Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form
Und Verformung.” Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000,
pp. 153–71.
short: H. Edelsbrunner, in:, Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000,
pp. 153–171.
date_created: 2018-12-11T12:04:01Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-02T13:07:14Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 153 - 171
publication: Zur Kunst des formalen Denkens
publication_identifier:
isbn:
- '3851653580'
publication_status: published
publisher: Passagen Verlag
publist_id: '2813'
quality_controlled: '1'
status: public
title: Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '3583'
abstract:
- lang: eng
text: The Delaunay triangulation of a finite point set is a central theme in computational
geometry. It finds its major application in the generation of meshes used in the
simulation of physical processes. This paper connects the predominantly combinatorial
work in classical computational geometry with the numerical interest in mesh generation.
It focuses on the two- and three-dimensional case and covers results obtained
during the twentieth century.
acknowledgement: Research is partially supported by the Army Research Office under
grant DAAG55-98-1-0177 and by the National Science Foundation under grants CCR-96-19542
and CCR-97-12088.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Triangulations and meshes in computational geometry. Acta
Numerica. 2000;9:133-213. doi:10.1017/S0962492900001331
apa: Edelsbrunner, H. (2000). Triangulations and meshes in computational geometry.
Acta Numerica. Cambridge University Press. https://doi.org/10.1017/S0962492900001331
chicago: Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.”
Acta Numerica. Cambridge University Press, 2000. https://doi.org/10.1017/S0962492900001331.
ieee: H. Edelsbrunner, “Triangulations and meshes in computational geometry,” Acta
Numerica, vol. 9. Cambridge University Press, pp. 133–213, 2000.
ista: Edelsbrunner H. 2000. Triangulations and meshes in computational geometry.
Acta Numerica. 9, 133–213.
mla: Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.”
Acta Numerica, vol. 9, Cambridge University Press, 2000, pp. 133–213, doi:10.1017/S0962492900001331.
short: H. Edelsbrunner, Acta Numerica 9 (2000) 133–213.
date_created: 2018-12-11T12:04:05Z
date_published: 2000-03-21T00:00:00Z
date_updated: 2023-05-02T12:20:27Z
day: '21'
doi: 10.1017/S0962492900001331
extern: '1'
intvolume: ' 9'
language:
- iso: eng
month: '03'
oa_version: None
page: 133 - 213
publication: Acta Numerica
publication_status: published
publisher: Cambridge University Press
publist_id: '2802'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulations and meshes in computational geometry
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 9
year: '2000'
...
---
_id: '3623'
abstract:
- lang: eng
text: 'We present the theoretical background to a new method for measuring genetic
variation for total fitness in Drosophila. The method allows heterozygous effects
on total fitness of whole wild-type chromosomes to be measured under normal demography
with overlapping generations. The wild-type chromosomes are competed against two
balancer chromosomes (B1, B2, say), providing a standard genotype B1/B2 against
which variation in the fitness effects of the wild-type chromosomes can be assessed.
Fitness can be assessed in two ways: (i) at equilibrium of all three chromosomes
under heterozygote advantage, and (ii) during displacement of one balancer by
the other. Equilibrium with all three chromosomes present will be achieved only
if the wild-type homozygote is not too fit, and if the fitnesses of the three
heterozygotes are not too unequal. These conditions were not satisfied for any
of a sample of 12 lethal-bearing chromosomes isolated from a random-bred laboratory
population of Drosophila. At equilibrium, genotypic frequencies show low sensitivity
to changes in genotypic fitness. Furthermore, where all four genotypes are viable
and fertile, supplementary information from cages with only two chromosomes present
and from direct measurements of pre-adult viability are required to estimate fitnesses
from frequencies. The invasion method has the advantages of a greater sensitivity
and of not requiring further data to estimate fitnesses if the wild-type homozygote
is fertile. However, it requires that multiple samples be taken as the invasion
progresses. In a discrete generation model, generation time influences fitness
estimates from this method and is difficult to estimate accurately from the data.
A full age-structured model can also be applied to the data from both types of
experiment. For the invasion method, this gives fitness estimates close to those
from the discrete generation model.'
acknowledgement: This work was supported by grant GR31/G09821 from the BBSRC, and
by fellowships from the Darwin Trust of Edinburgh and the NERC. We are grateful
to the referees for their helpful comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Patridge, Linda
last_name: Patridge
citation:
ama: Barton NH, Patridge L. Measuring fitness by means of balancer chromosomes.
Genetical Research. 2000;75(3):297-314. doi:10.1017/S0016672399004346
apa: Barton, N. H., & Patridge, L. (2000). Measuring fitness by means of balancer
chromosomes. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672399004346
chicago: Barton, Nicholas H, and Linda Patridge. “Measuring Fitness by Means of
Balancer Chromosomes.” Genetical Research. Cambridge University Press,
2000. https://doi.org/10.1017/S0016672399004346.
ieee: N. H. Barton and L. Patridge, “Measuring fitness by means of balancer chromosomes,”
Genetical Research, vol. 75, no. 3. Cambridge University Press, pp. 297–314,
2000.
ista: Barton NH, Patridge L. 2000. Measuring fitness by means of balancer chromosomes.
Genetical Research. 75(3), 297–314.
mla: Barton, Nicholas H., and Linda Patridge. “Measuring Fitness by Means of Balancer
Chromosomes.” Genetical Research, vol. 75, no. 3, Cambridge University
Press, 2000, pp. 297–314, doi:10.1017/S0016672399004346.
short: N.H. Barton, L. Patridge, Genetical Research 75 (2000) 297–314.
date_created: 2018-12-11T12:04:18Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-02T12:09:23Z
day: '01'
doi: 10.1017/S0016672399004346
extern: '1'
external_id:
pmid:
- '10893866'
intvolume: ' 75'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 297 - 314
pmid: 1
publication: Genetical Research
publication_identifier:
issn:
- 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2760'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Measuring fitness by means of balancer chromosomes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 75
year: '2000'
...