---
_id: '1957'
abstract:
- lang: eng
  text: NADH:ubiquinone oxidoreductase (complex I) is the first and largest enzyme
    of the mitochondrial respiratory chain. The low-resolution structure of the complex
    is known from electron microscopy studies. The general shape of the complex is
    in the form of an L, with one arm in the membrane and the other peripheral. We
    have purified complex I from beef heart mitochondria and reconstituted the enzyme
    into lipid bilayers. Under different conditions, several two-dimensional crystal
    forms were obtained. Crystals belonging to space groups p2221 and c12 (unit cell
    488 Å x 79 Å) were obtained at 22°C and contained only the membrane fragment of
    complex I similar to hydrophobic subcomplex Iβ but lacking the ND5 subunit. A
    crystal form with larger unit cell (534 Å x 81 Å, space group c12) produced at
    4°C contained both the peripheral and membrane arms of the enzyme, except that
    ND5 was missing. Projection maps from frozen hydrated samples were calculated
    for all crystal forms. By comparing two different c12 crystal forms, extra electron
    density in the projection map of large crystal form was assigned to the peripheral
    arm of the enzyme. One of the features of the map is a deep, channel-like, cleft
    next to peripheral arm. Comparison with available structures of the intact enzyme
    indicates that large hydrophobic subunit ND5 is situated at the distal end of
    the membrane domain. Possible locations of sub-unit ND4 and of other subunits
    in the membrane domain are proposed. Implications of our findings for the mechanism
    of proton pumping by complex I are discussed. (C) 2000 Academic Press.
acknowledgement: We thank Drs I. M. Fearnley and S. Y. Peak-Chew for performing peptide
  mass mapping. We also thank Drs R. Henderson and G. F. X. Schertler for advice on
  image processing and for valuable discussions.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: John
  full_name: Walker, John
  last_name: Walker
citation:
  ama: Sazanov LA, Walker J. Cryo-electron crystallography of two sub-complexes of
    bovine complex I reveals the relationship between the membrane and peripheral
    arms. <i>Journal of Molecular Biology</i>. 2000;302(2):455-464. doi:<a href="https://doi.org/10.1006/jmbi.2000.4079">10.1006/jmbi.2000.4079</a>
  apa: Sazanov, L. A., &#38; Walker, J. (2000). Cryo-electron crystallography of two
    sub-complexes of bovine complex I reveals the relationship between the membrane
    and peripheral arms. <i>Journal of Molecular Biology</i>. Elsevier. <a href="https://doi.org/10.1006/jmbi.2000.4079">https://doi.org/10.1006/jmbi.2000.4079</a>
  chicago: Sazanov, Leonid A, and John Walker. “Cryo-Electron Crystallography of Two
    Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane
    and Peripheral Arms.” <i>Journal of Molecular Biology</i>. Elsevier, 2000. <a
    href="https://doi.org/10.1006/jmbi.2000.4079">https://doi.org/10.1006/jmbi.2000.4079</a>.
  ieee: L. A. Sazanov and J. Walker, “Cryo-electron crystallography of two sub-complexes
    of bovine complex I reveals the relationship between the membrane and peripheral
    arms,” <i>Journal of Molecular Biology</i>, vol. 302, no. 2. Elsevier, pp. 455–464,
    2000.
  ista: Sazanov LA, Walker J. 2000. Cryo-electron crystallography of two sub-complexes
    of bovine complex I reveals the relationship between the membrane and peripheral
    arms. Journal of Molecular Biology. 302(2), 455–464.
  mla: Sazanov, Leonid A., and John Walker. “Cryo-Electron Crystallography of Two
    Sub-Complexes of Bovine Complex I Reveals the Relationship between the Membrane
    and Peripheral Arms.” <i>Journal of Molecular Biology</i>, vol. 302, no. 2, Elsevier,
    2000, pp. 455–64, doi:<a href="https://doi.org/10.1006/jmbi.2000.4079">10.1006/jmbi.2000.4079</a>.
  short: L.A. Sazanov, J. Walker, Journal of Molecular Biology 302 (2000) 455–464.
date_created: 2018-12-11T11:54:55Z
date_published: 2000-09-15T00:00:00Z
date_updated: 2023-05-04T13:23:03Z
day: '15'
doi: 10.1006/jmbi.2000.4079
extern: '1'
external_id:
  pmid:
  - '10970745'
intvolume: '       302'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 455 - 464
pmid: 1
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
publist_id: '5126'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cryo-electron crystallography of two sub-complexes of bovine complex I reveals
  the relationship between the membrane and peripheral arms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 302
year: '2000'
...
---
_id: '1958'
abstract:
- lang: eng
  text: "\r\nComplex I (NADH:ubiquinone oxidoreductase) purified from bovine heart
    mitochondria was treated with the detergent N,N-dimethyldodecylamine N-oxide (LDAO).
    The enzyme dissociated into two known subcomplexes, Iα and Iβ, containing mostly
    hydrophilic and hydrophobic subunits, and a previously undetected fragment referred
    to as Iγ. Subcomplex Iγ contains the hydrophobic subunits ND1, ND2, ND3, and ND4L
    which are encoded in the mitochondrial genome, and the nuclear-encoded subunit
    KFYL. During size- exclusion chromatography in the presence of LDAO, subcomplex
    Iα lost several subunits and formed another characterized subcomplex known as
    Iλ. Similarly, subcomplex Iβ dissociated into two smaller subcomplexes, one of
    which contains the hydrophobic subunits ND4 and ND5; subcomplex Iγ released a
    fragment containing ND1 and ND2. These results suggest that in the intact complex
    subunits ND1 and ND2 are likely to be in a different region of the membrane domain
    than subunits ND4 and ND5. The compositions of the various subcomplexes and fragments
    of complex I provide an organization of the subunits of the enzyme in the framework
    of the known low resolution structure of the enzyme."
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Sew
  full_name: Peak Chew, Sew
  last_name: Peak Chew
- first_name: Ian
  full_name: Fearnley, Ian
  last_name: Fearnley
- first_name: John
  full_name: Walker, John
  last_name: Walker
citation:
  ama: 'Sazanov LA, Peak Chew S, Fearnley I, Walker J. Resolution of the membrane
    domain of bovine complex I into subcomplexes: implications for the structural
    organization of the enzyme. <i>Biochemistry</i>. 2000;39(24):7229-7235. doi:<a
    href="https://doi.org/10.1021/bi000335t">10.1021/bi000335t</a>'
  apa: 'Sazanov, L. A., Peak Chew, S., Fearnley, I., &#38; Walker, J. (2000). Resolution
    of the membrane domain of bovine complex I into subcomplexes: implications for
    the structural organization of the enzyme. <i>Biochemistry</i>. ACS. <a href="https://doi.org/10.1021/bi000335t">https://doi.org/10.1021/bi000335t</a>'
  chicago: 'Sazanov, Leonid A, Sew Peak Chew, Ian Fearnley, and John Walker. “Resolution
    of the Membrane Domain of Bovine Complex I into Subcomplexes: Implications for
    the Structural Organization of the Enzyme.” <i>Biochemistry</i>. ACS, 2000. <a
    href="https://doi.org/10.1021/bi000335t">https://doi.org/10.1021/bi000335t</a>.'
  ieee: 'L. A. Sazanov, S. Peak Chew, I. Fearnley, and J. Walker, “Resolution of the
    membrane domain of bovine complex I into subcomplexes: implications for the structural
    organization of the enzyme,” <i>Biochemistry</i>, vol. 39, no. 24. ACS, pp. 7229–7235,
    2000.'
  ista: 'Sazanov LA, Peak Chew S, Fearnley I, Walker J. 2000. Resolution of the membrane
    domain of bovine complex I into subcomplexes: implications for the structural
    organization of the enzyme. Biochemistry. 39(24), 7229–7235.'
  mla: 'Sazanov, Leonid A., et al. “Resolution of the Membrane Domain of Bovine Complex
    I into Subcomplexes: Implications for the Structural Organization of the Enzyme.”
    <i>Biochemistry</i>, vol. 39, no. 24, ACS, 2000, pp. 7229–35, doi:<a href="https://doi.org/10.1021/bi000335t">10.1021/bi000335t</a>.'
  short: L.A. Sazanov, S. Peak Chew, I. Fearnley, J. Walker, Biochemistry 39 (2000)
    7229–7235.
date_created: 2018-12-11T11:54:55Z
date_published: 2000-05-24T00:00:00Z
date_updated: 2023-05-04T14:14:53Z
day: '24'
doi: 10.1021/bi000335t
extern: '1'
external_id:
  pmid:
  - '10852722'
intvolume: '        39'
issue: '24'
language:
- iso: eng
month: '05'
oa_version: None
page: 7229 - 7235
pmid: 1
publication: Biochemistry
publication_identifier:
  issn:
  - 0006-2960
publication_status: published
publisher: ACS
publist_id: '5127'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Resolution of the membrane domain of bovine complex I into subcomplexes: implications
  for the structural organization of the enzyme'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 39
year: '2000'
...
---
_id: '13437'
abstract:
- lang: eng
  text: Liquid/liquid Phase Transfer Catalysis (PTC) reaction of 4-chlorobutyronitrile
    with nonenolisable aldehydes leads via an addition-cyclisation reaction sequence
    to derivatives of tetrahydrofuran-3-carbonitrile.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Mieczysław
  full_name: Macogonkosza, Mieczysław
  last_name: Macogonkosza
- first_name: Jacek
  full_name: Przyborowski, Jacek
  last_name: Przyborowski
- first_name: Rafal
  full_name: Klajn, Rafal
  id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
  last_name: Klajn
- first_name: Andrzej
  full_name: Kwast, Andrzej
  last_name: Kwast
citation:
  ama: Macogonkosza M, Przyborowski J, Klajn R, Kwast A. Simple synthesis of 2-substituted
    Tetrahydrofuran-3-carbonitriles. <i>Synlett</i>. 2000;2000(12):1773-1774. doi:<a
    href="https://doi.org/10.1055/s-2000-8670">10.1055/s-2000-8670</a>
  apa: Macogonkosza, M., Przyborowski, J., Klajn, R., &#38; Kwast, A. (2000). Simple
    synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles. <i>Synlett</i>. Georg
    Thieme Verlag. <a href="https://doi.org/10.1055/s-2000-8670">https://doi.org/10.1055/s-2000-8670</a>
  chicago: Macogonkosza, Mieczysław, Jacek Przyborowski, Rafal Klajn, and Andrzej
    Kwast. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.” <i>Synlett</i>.
    Georg Thieme Verlag, 2000. <a href="https://doi.org/10.1055/s-2000-8670">https://doi.org/10.1055/s-2000-8670</a>.
  ieee: M. Macogonkosza, J. Przyborowski, R. Klajn, and A. Kwast, “Simple synthesis
    of 2-substituted Tetrahydrofuran-3-carbonitriles,” <i>Synlett</i>, vol. 2000,
    no. 12. Georg Thieme Verlag, pp. 1773–1774, 2000.
  ista: Macogonkosza M, Przyborowski J, Klajn R, Kwast A. 2000. Simple synthesis of
    2-substituted Tetrahydrofuran-3-carbonitriles. Synlett. 2000(12), 1773–1774.
  mla: Macogonkosza, Mieczysław, et al. “Simple Synthesis of 2-Substituted Tetrahydrofuran-3-Carbonitriles.”
    <i>Synlett</i>, vol. 2000, no. 12, Georg Thieme Verlag, 2000, pp. 1773–74, doi:<a
    href="https://doi.org/10.1055/s-2000-8670">10.1055/s-2000-8670</a>.
  short: M. Macogonkosza, J. Przyborowski, R. Klajn, A. Kwast, Synlett 2000 (2000)
    1773–1774.
date_created: 2023-08-01T10:39:48Z
date_published: 2000-12-01T00:00:00Z
date_updated: 2023-08-02T07:54:46Z
day: '01'
doi: 10.1055/s-2000-8670
extern: '1'
intvolume: '      2000'
issue: '12'
keyword:
- Organic Chemistry
language:
- iso: eng
month: '12'
oa_version: None
page: 1773-1774
publication: Synlett
publication_identifier:
  eissn:
  - 1437-2096
  issn:
  - 0936-5214
publication_status: published
publisher: Georg Thieme Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simple synthesis of 2-substituted Tetrahydrofuran-3-carbonitriles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2000
year: '2000'
...
---
_id: '1455'
abstract:
- lang: eng
  text: First, a special case of Knaster's problem is proved implying that each symmetric
    convex body in ℝ3 admits an inscribed cube. It is deduced from a theorem in equivariant
    topology, which says that there is no S4 - equivariant map from SO(3) to S2, where
    S4 acts on SO(3) on the right as the rotation group of the cube, and on S2 on
    the right as the symmetry group of the regular tetrahedron. Some generalizations
    are also given. Second, it is shown how the above non-existence theorem yields
    Makeev's conjecture in ℝ3 that each set in ℝ3 of diameter 1 can be covered by
    a rhombic dodecahedron, which has distance 1 between its opposite faces. This
    reveals an unexpected connection between inscribing cubes into symmetric bodies
    and covering sets by rhombic dodecahedra. Finally, a possible application of our
    second theorem to the Borsuk problem in ℝ3 is pointed out.
acknowledgement: The research of the first author was partially supported by Trinity
  College, Cambridge, and that of all the authors by grants 23444, T-030012 and A
  046/96, respectively, from the Hungarian National Foundation for Scientific Research.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
- first_name: Endre
  full_name: Makai, Endre
  last_name: Makai
- first_name: András
  full_name: Szücs, András
  last_name: Szücs
citation:
  ama: Hausel T, Makai E, Szücs A. Inscribing cubes and covering by rhombic dodecahedra
    via equivariant topology. <i>Mathematika</i>. 2000;47(1-2):371-397. doi:<a href="https://doi.org/10.1112/S0025579300015965">10.1112/S0025579300015965</a>
  apa: Hausel, T., Makai, E., &#38; Szücs, A. (2000). Inscribing cubes and covering
    by rhombic dodecahedra via equivariant topology. <i>Mathematika</i>. University
    College London. <a href="https://doi.org/10.1112/S0025579300015965">https://doi.org/10.1112/S0025579300015965</a>
  chicago: Hausel, Tamás, Endre Makai, and András Szücs. “Inscribing Cubes and Covering
    by Rhombic Dodecahedra via Equivariant Topology.” <i>Mathematika</i>. University
    College London, 2000. <a href="https://doi.org/10.1112/S0025579300015965">https://doi.org/10.1112/S0025579300015965</a>.
  ieee: T. Hausel, E. Makai, and A. Szücs, “Inscribing cubes and covering by rhombic
    dodecahedra via equivariant topology,” <i>Mathematika</i>, vol. 47, no. 1–2. University
    College London, pp. 371–397, 2000.
  ista: Hausel T, Makai E, Szücs A. 2000. Inscribing cubes and covering by rhombic
    dodecahedra via equivariant topology. Mathematika. 47(1–2), 371–397.
  mla: Hausel, Tamás, et al. “Inscribing Cubes and Covering by Rhombic Dodecahedra
    via Equivariant Topology.” <i>Mathematika</i>, vol. 47, no. 1–2, University College
    London, 2000, pp. 371–97, doi:<a href="https://doi.org/10.1112/S0025579300015965">10.1112/S0025579300015965</a>.
  short: T. Hausel, E. Makai, A. Szücs, Mathematika 47 (2000) 371–397.
date_created: 2018-12-11T11:52:07Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-08T08:56:46Z
day: '01'
doi: 10.1112/S0025579300015965
extern: '1'
external_id:
  arxiv:
  - math/9906066
intvolume: '        47'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math/9906066
month: '06'
oa: 1
oa_version: Preprint
page: 371 - 397
publication: Mathematika
publication_identifier:
  issn:
  - 0025-5793
publication_status: published
publisher: University College London
publist_id: '5745'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inscribing cubes and covering by rhombic dodecahedra via equivariant topology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '2000'
...
---
_id: '11126'
abstract:
- lang: eng
  text: Nuclear import of the two uracil-rich small nuclear ribonucleoprotein (U snRNP)
    components U1A and U2B′′ is mediated by unusually long and complex nuclear localization
    signals (NLSs). Here we investigate nuclear import of U1A and U2B′′ in vitro and
    demonstrate that it occurs by an active, saturable process. Several lines of evidence
    suggest that import of the two proteins occurs by an import mechanism different
    to those characterized previously. No cross competition is seen with a variety
    of previously studied NLSs. In contrast to import mediated by members of the importin-β
    family of nucleocytoplasmic transport receptors, U1A/U2B′′ import is not inhibited
    by either nonhydrolyzable guanosine triphosphate (GTP) analogues or by a mutant
    of the GTPase Ran that is incapable of GTP hydrolysis. Adenosine triphosphate
    is capable of supporting U1A and U2B′′ import, whereas neither nonhydrolyzable
    adenosine triphosphate analogues nor GTP can do so. U1A and U2B′′ import in vitro
    does not require the addition of soluble cytosolic proteins, but a factor or factors
    required for U1A and U2B′′ import remains tightly associated with the nuclear
    fraction of conventionally permeabilized cells. This activity can be solubilized
    in the presence of elevated MgCl2. These data suggest that U1A and U2B′′ import
    into the nucleus occurs by a hitherto uncharacterized mechanism.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
- first_name: Iain W.
  full_name: Mattaj, Iain W.
  last_name: Mattaj
citation:
  ama: Hetzer M, Mattaj IW. An Atp-dependent, Ran-independent mechanism for nuclear
    import of the U1a and U2b′′ spliceosome proteins. <i>Journal of Cell Biology</i>.
    2000;148(2):293-304. doi:<a href="https://doi.org/10.1083/jcb.148.2.293">10.1083/jcb.148.2.293</a>
  apa: Hetzer, M., &#38; Mattaj, I. W. (2000). An Atp-dependent, Ran-independent mechanism
    for nuclear import of the U1a and U2b′′ spliceosome proteins. <i>Journal of Cell
    Biology</i>. Rockefeller University Press. <a href="https://doi.org/10.1083/jcb.148.2.293">https://doi.org/10.1083/jcb.148.2.293</a>
  chicago: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent
    Mechanism for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” <i>Journal
    of Cell Biology</i>. Rockefeller University Press, 2000. <a href="https://doi.org/10.1083/jcb.148.2.293">https://doi.org/10.1083/jcb.148.2.293</a>.
  ieee: M. Hetzer and I. W. Mattaj, “An Atp-dependent, Ran-independent mechanism for
    nuclear import of the U1a and U2b′′ spliceosome proteins,” <i>Journal of Cell
    Biology</i>, vol. 148, no. 2. Rockefeller University Press, pp. 293–304, 2000.
  ista: Hetzer M, Mattaj IW. 2000. An Atp-dependent, Ran-independent mechanism for
    nuclear import of the U1a and U2b′′ spliceosome proteins. Journal of Cell Biology.
    148(2), 293–304.
  mla: Hetzer, Martin, and Iain W. Mattaj. “An Atp-Dependent, Ran-Independent Mechanism
    for Nuclear Import of the U1a and U2b′′ Spliceosome Proteins.” <i>Journal of Cell
    Biology</i>, vol. 148, no. 2, Rockefeller University Press, 2000, pp. 293–304,
    doi:<a href="https://doi.org/10.1083/jcb.148.2.293">10.1083/jcb.148.2.293</a>.
  short: M. Hetzer, I.W. Mattaj, Journal of Cell Biology 148 (2000) 293–304.
date_created: 2022-04-07T07:57:49Z
date_published: 2000-01-24T00:00:00Z
date_updated: 2022-07-18T08:58:29Z
day: '24'
doi: 10.1083/jcb.148.2.293
extern: '1'
external_id:
  pmid:
  - '10648562'
intvolume: '       148'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
month: '01'
oa_version: None
page: 293-304
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: An Atp-dependent, Ran-independent mechanism for nuclear import of the U1a and
  U2b′′ spliceosome proteins
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 148
year: '2000'
...
---
_id: '11127'
abstract:
- lang: eng
  text: Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited
    by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE)
    vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran
    GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for
    Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion
    can be complemented by the addition of Ran loaded with either GTP or GDP but not
    with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus,
    generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the
    extensive membrane fusion events that lead to NE formation.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
- first_name: Daniel
  full_name: Bilbao-Cortés, Daniel
  last_name: Bilbao-Cortés
- first_name: Tobias C
  full_name: Walther, Tobias C
  last_name: Walther
- first_name: Oliver J
  full_name: Gruss, Oliver J
  last_name: Gruss
- first_name: Iain W
  full_name: Mattaj, Iain W
  last_name: Mattaj
citation:
  ama: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis
    by Ran is required for nuclear envelope assembly. <i>Molecular Cell</i>. 2000;5(6):1013-1024.
    doi:<a href="https://doi.org/10.1016/s1097-2765(00)80266-x">10.1016/s1097-2765(00)80266-x</a>
  apa: Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., &#38; Mattaj,
    I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly.
    <i>Molecular Cell</i>. Elsevier. <a href="https://doi.org/10.1016/s1097-2765(00)80266-x">https://doi.org/10.1016/s1097-2765(00)80266-x</a>
  chicago: Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss,
    and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.”
    <i>Molecular Cell</i>. Elsevier, 2000. <a href="https://doi.org/10.1016/s1097-2765(00)80266-x">https://doi.org/10.1016/s1097-2765(00)80266-x</a>.
  ieee: M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj,
    “GTP hydrolysis by Ran is required for nuclear envelope assembly,” <i>Molecular
    Cell</i>, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000.
  ista: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis
    by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.
  mla: Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope
    Assembly.” <i>Molecular Cell</i>, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24,
    doi:<a href="https://doi.org/10.1016/s1097-2765(00)80266-x">10.1016/s1097-2765(00)80266-x</a>.
  short: M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular
    Cell 5 (2000) 1013–1024.
date_created: 2022-04-07T07:57:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-07-18T08:58:31Z
day: '01'
doi: 10.1016/s1097-2765(00)80266-x
extern: '1'
external_id:
  pmid:
  - '10911995'
intvolume: '         5'
issue: '6'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/S1097-2765(00)80266-X
month: '06'
oa: 1
oa_version: Published Version
page: 1013-1024
pmid: 1
publication: Molecular Cell
publication_identifier:
  issn:
  - 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GTP hydrolysis by Ran is required for nuclear envelope assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 5
year: '2000'
...
---
_id: '11683'
abstract:
- lang: eng
  text: The vertex connectivity κ of a graph is the smallest number of vertices whose
    deletion separates the graph or makes it trivial. We present the fastest known
    deterministic algorithm for finding the vertex connectivity and a corresponding
    separator. The time for a digraph having n vertices and m edges is O(min{κ3 +
    n, κn}m); for an undirected graph the term m can be replaced by κn. A randomized
    algorithm finds κ with error probability 1/2 in time O(nm). If the vertices have
    nonnegative weights the weighted vertex connectivity is found in time O(κ1nmlog(n2/m))
    where κ1 ≤ m/n is the unweighted vertex connectivity or in expected time O(nmlog(n2/m))
    with error probability 1/2. The main algorithm combines two previous vertex connectivity
    algorithms and a generalization of the preflow-push algorithm of Hao and Orlin
    (1994, J. Algorithms17, 424–446) that computes edge connectivity.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Satish
  full_name: Rao, Satish
  last_name: Rao
- first_name: Harold N.
  full_name: Gabow, Harold N.
  last_name: Gabow
citation:
  ama: 'Henzinger MH, Rao S, Gabow HN. Computing vertex connectivity: New bounds from
    old techniques. <i>Journal of Algorithms</i>. 2000;34(2):222-250. doi:<a href="https://doi.org/10.1006/jagm.1999.1055">10.1006/jagm.1999.1055</a>'
  apa: 'Henzinger, M. H., Rao, S., &#38; Gabow, H. N. (2000). Computing vertex connectivity:
    New bounds from old techniques. <i>Journal of Algorithms</i>. Elsevier. <a href="https://doi.org/10.1006/jagm.1999.1055">https://doi.org/10.1006/jagm.1999.1055</a>'
  chicago: 'Henzinger, Monika H, Satish Rao, and Harold N. Gabow. “Computing Vertex
    Connectivity: New Bounds from Old Techniques.” <i>Journal of Algorithms</i>. Elsevier,
    2000. <a href="https://doi.org/10.1006/jagm.1999.1055">https://doi.org/10.1006/jagm.1999.1055</a>.'
  ieee: 'M. H. Henzinger, S. Rao, and H. N. Gabow, “Computing vertex connectivity:
    New bounds from old techniques,” <i>Journal of Algorithms</i>, vol. 34, no. 2.
    Elsevier, pp. 222–250, 2000.'
  ista: 'Henzinger MH, Rao S, Gabow HN. 2000. Computing vertex connectivity: New bounds
    from old techniques. Journal of Algorithms. 34(2), 222–250.'
  mla: 'Henzinger, Monika H., et al. “Computing Vertex Connectivity: New Bounds from
    Old Techniques.” <i>Journal of Algorithms</i>, vol. 34, no. 2, Elsevier, 2000,
    pp. 222–50, doi:<a href="https://doi.org/10.1006/jagm.1999.1055">10.1006/jagm.1999.1055</a>.'
  short: M.H. Henzinger, S. Rao, H.N. Gabow, Journal of Algorithms 34 (2000) 222–250.
date_created: 2022-07-28T08:56:10Z
date_published: 2000-02-01T00:00:00Z
date_updated: 2022-09-12T09:06:48Z
day: '01'
doi: 10.1006/jagm.1999.1055
extern: '1'
intvolume: '        34'
issue: '2'
keyword:
- Computational Theory and Mathematics
- Computational Mathematics
- Control and Optimization
language:
- iso: eng
month: '02'
oa_version: None
page: 222-250
publication: Journal of Algorithms
publication_identifier:
  issn:
  - 0196-6774
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Computing vertex connectivity: New bounds from old techniques'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2000'
...
---
_id: '11685'
abstract:
- lang: eng
  text: We consider the problem of sampling URLs uniformly at random from the Web.
    A tool for sampling URLs uniformly can be used to estimate various properties
    of Web pages, such as the fraction of pages in various Internet domains or written
    in various languages. Moreover, uniform URL sampling can be used to determine
    the sizes of various search engines relative to the entire Web. In this paper,
    we consider sampling approaches based on random walks of the Web graph. In particular,
    we suggest ways of improving sampling based on random walks to make the samples
    closer to uniform. We suggest a natural test bed based on random graphs for testing
    the effectiveness of our procedures. We then use our sampling approach to estimate
    the distribution of pages over various Internet domains and to estimate the coverage
    of various search engine indexes.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Allan
  full_name: Heydon, Allan
  last_name: Heydon
- first_name: Michael
  full_name: Mitzenmacher, Michael
  last_name: Mitzenmacher
- first_name: Marc
  full_name: Najork, Marc
  last_name: Najork
citation:
  ama: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. On near-uniform URL sampling.
    <i>Computer Networks</i>. 2000;33(1-6):295-308. doi:<a href="https://doi.org/10.1016/s1389-1286(00)00055-4">10.1016/s1389-1286(00)00055-4</a>
  apa: Henzinger, M. H., Heydon, A., Mitzenmacher, M., &#38; Najork, M. (2000). On
    near-uniform URL sampling. <i>Computer Networks</i>. Elsevier. <a href="https://doi.org/10.1016/s1389-1286(00)00055-4">https://doi.org/10.1016/s1389-1286(00)00055-4</a>
  chicago: Henzinger, Monika H, Allan Heydon, Michael Mitzenmacher, and Marc Najork.
    “On Near-Uniform URL Sampling.” <i>Computer Networks</i>. Elsevier, 2000. <a href="https://doi.org/10.1016/s1389-1286(00)00055-4">https://doi.org/10.1016/s1389-1286(00)00055-4</a>.
  ieee: M. H. Henzinger, A. Heydon, M. Mitzenmacher, and M. Najork, “On near-uniform
    URL sampling,” <i>Computer Networks</i>, vol. 33, no. 1–6. Elsevier, pp. 295–308,
    2000.
  ista: Henzinger MH, Heydon A, Mitzenmacher M, Najork M. 2000. On near-uniform URL
    sampling. Computer Networks. 33(1–6), 295–308.
  mla: Henzinger, Monika H., et al. “On Near-Uniform URL Sampling.” <i>Computer Networks</i>,
    vol. 33, no. 1–6, Elsevier, 2000, pp. 295–308, doi:<a href="https://doi.org/10.1016/s1389-1286(00)00055-4">10.1016/s1389-1286(00)00055-4</a>.
  short: M.H. Henzinger, A. Heydon, M. Mitzenmacher, M. Najork, Computer Networks
    33 (2000) 295–308.
date_created: 2022-07-28T15:11:53Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-09-12T09:09:13Z
day: '01'
doi: 10.1016/s1389-1286(00)00055-4
extern: '1'
intvolume: '        33'
issue: 1-6
keyword:
- URL sampling
- Random walks
- Internet domain distribution
- Search engine size
language:
- iso: eng
month: '06'
oa_version: None
page: 295-308
publication: Computer Networks
publication_identifier:
  issn:
  - 1389-1286
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On near-uniform URL sampling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2000'
...
---
_id: '11694'
abstract:
- lang: eng
  text: We consider exploration problems where a robot has to construct a complete
    map of an unknown environment. We assume that the environment is modeled by a
    directed, strongly connected graph. The robot's task is to visit all nodes and
    edges of the graph using the minimum number R of edge traversals. Deng and Papadimitriou
    [Proceedings of the 31st Symposium on the Foundations of Computer Science, 1990,
    pp. 356-361] showed an upper bound for R ofd O(d)m and Koutsoupias (reported by
    Deng and Papadimitriou) gave a lower bound of Ω≠(d2m), where m is the number of
    edges in the graph and d is the minimum number of edges that have to be added
    to make the graph Eulerian.  We give the 1rst subexponential algorithm for this
    exploration problem, which achieves an upper bound of dO(logd)m.  We also show
    a matching lower bound of d≠(logd)m for our algorithm. Additionally, we give lower
    bounds of 2≠(d)m, respectively, d≠(logd)m for various other natural exploration
    algorithms.
acknowledgement: We thank Prabhakar Raghavan for bringing to our attention the literature
  on the s-t connectivity  problem. We also thank  an anonymous referee for many helpful
  comments which improved the presentation of the paper.
article_processing_charge: No
article_type: original
author:
- first_name: Susanne
  full_name: Albers, Susanne
  last_name: Albers
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: Albers S, Henzinger MH. Exploring unknown environments. <i>SIAM Journal on
    Computing</i>. 2000;29(4):1164-1188. doi:<a href="https://doi.org/10.1137/s009753979732428x">10.1137/s009753979732428x</a>
  apa: 'Albers, S., &#38; Henzinger, M. H. (2000). Exploring unknown environments.
    <i>SIAM Journal on Computing</i>. El Paso, TX, United States: Society for Industrial
    and Applied Mathematics. <a href="https://doi.org/10.1137/s009753979732428x">https://doi.org/10.1137/s009753979732428x</a>'
  chicago: Albers, Susanne, and Monika H Henzinger. “Exploring Unknown Environments.”
    <i>SIAM Journal on Computing</i>. Society for Industrial and Applied Mathematics,
    2000. <a href="https://doi.org/10.1137/s009753979732428x">https://doi.org/10.1137/s009753979732428x</a>.
  ieee: S. Albers and M. H. Henzinger, “Exploring unknown environments,” <i>SIAM Journal
    on Computing</i>, vol. 29, no. 4. Society for Industrial and Applied Mathematics,
    pp. 1164–1188, 2000.
  ista: Albers S, Henzinger MH. 2000. Exploring unknown environments. SIAM Journal
    on Computing. 29(4), 1164–1188.
  mla: Albers, Susanne, and Monika H. Henzinger. “Exploring Unknown Environments.”
    <i>SIAM Journal on Computing</i>, vol. 29, no. 4, Society for Industrial and Applied
    Mathematics, 2000, pp. 1164–88, doi:<a href="https://doi.org/10.1137/s009753979732428x">10.1137/s009753979732428x</a>.
  short: S. Albers, M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1164–1188.
conference:
  end_date: 1997-05-06
  location: El Paso, TX, United States
  name: 'STOC97: 29th Annual Symposium on Theory of Computing'
  start_date: 1997-05-04
date_created: 2022-07-29T09:04:36Z
date_published: 2000-07-01T00:00:00Z
date_updated: 2023-02-17T14:41:36Z
day: '01'
doi: 10.1137/s009753979732428x
extern: '1'
intvolume: '        29'
issue: '4'
keyword:
- directed graph
- exploration algorithm
language:
- iso: eng
month: '07'
oa_version: None
page: 1164-1188
publication: SIAM Journal on Computing
publication_identifier:
  eissn:
  - 1095-7111
  issn:
  - 0097-5397
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Exploring unknown environments
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '11770'
abstract:
- lang: eng
  text: 'We compare several algorithms for identifying mirrored hosts on the World
    Wide Web. The algorithms operate on the basis of URL strings and linkage data:
    the type of information about Web pages easily available from Web proxies and
    crawlers. Identification of mirrored hosts can improve Web-based information retrieval
    in several ways: first, by identifying mirrored hosts, search engines can avoid
    storing and returning duplicate documents. Second, several new information retrieval
    techniques for the Web make inferences based on the explicit links among hypertext
    documents—mirroring perturbs their graph model and degrades performance. Third,
    mirroring information can be used to redirect users to alternate mirror sites
    to compensate for various failures, and can thus improve the performance of Web
    browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting
    mirrored host pairs (that is, algorithms that are based on page attributes such
    as URL, IP address, and hyperlinks between pages, and not on the page content)
    on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity
    information. Our best approach is one which combines five algorithms and achieved
    a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.'
article_processing_charge: No
article_type: original
author:
- first_name: Krishna
  full_name: Bharat, Krishna
  last_name: Bharat
- first_name: Andrei
  full_name: Broder, Andrei
  last_name: Broder
- first_name: Jeffrey
  full_name: Dean, Jeffrey
  last_name: Dean
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find
    mirrored hosts on the WWW. <i>Journal of the American Society for Information
    Science</i>. 2000;51(12):1114-1122. doi:<a href="https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0">10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>
  apa: Bharat, K., Broder, A., Dean, J., &#38; Henzinger, M. H. (2000). A comparison
    of techniques to find mirrored hosts on the WWW. <i>Journal of the American Society
    for Information Science</i>. Wiley. <a href="https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0">https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>
  chicago: Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A
    Comparison of Techniques to Find Mirrored Hosts on the WWW.” <i>Journal of the
    American Society for Information Science</i>. Wiley, 2000. <a href="https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0">https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>.
  ieee: K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques
    to find mirrored hosts on the WWW,” <i>Journal of the American Society for Information
    Science</i>, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.
  ista: Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques
    to find mirrored hosts on the WWW. Journal of the American Society for Information
    Science. 51(12), 1114–1122.
  mla: Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts
    on the WWW.” <i>Journal of the American Society for Information Science</i>, vol.
    51, no. 12, Wiley, 2000, pp. 1114–22, doi:<a href="https://doi.org/10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0">10.1002/1097-4571(2000)9999:9999&#60;::aid-asi1025&#62;3.0.co;2-0</a>.
  short: K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society
    for Information Science 51 (2000) 1114–1122.
date_created: 2022-08-08T12:57:37Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-02-10T08:27:19Z
day: '01'
doi: 10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
extern: '1'
intvolume: '        51'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
month: '10'
oa: 1
oa_version: Published Version
page: 1114-1122
publication: Journal of the American Society for Information Science
publication_identifier:
  issn:
  - 0002-8231
  - 1097-4571
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of techniques to find mirrored hosts on the WWW
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2000'
...
---
_id: '11802'
abstract:
- lang: eng
  text: In this paper we survey algorithmic aspects of Web information retrieval.
    As an example, we discuss ranking of search engine results using connectivity
    analysis.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: 'Henzinger MH. Web information retrieval - an algorithmic perspective. In:
    <i>8th Annual European Symposium on Algorithms</i>. Vol 1879. Springer Nature;
    2000:1–8. doi:<a href="https://doi.org/10.1007/3-540-45253-2_1">10.1007/3-540-45253-2_1</a>'
  apa: 'Henzinger, M. H. (2000). Web information retrieval - an algorithmic perspective.
    In <i>8th Annual European Symposium on Algorithms</i> (Vol. 1879, pp. 1–8). Saarbrücken,
    Germany: Springer Nature. <a href="https://doi.org/10.1007/3-540-45253-2_1">https://doi.org/10.1007/3-540-45253-2_1</a>'
  chicago: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
    In <i>8th Annual European Symposium on Algorithms</i>, 1879:1–8. Springer Nature,
    2000. <a href="https://doi.org/10.1007/3-540-45253-2_1">https://doi.org/10.1007/3-540-45253-2_1</a>.
  ieee: M. H. Henzinger, “Web information retrieval - an algorithmic perspective,”
    in <i>8th Annual European Symposium on Algorithms</i>, Saarbrücken, Germany, 2000,
    vol. 1879, pp. 1–8.
  ista: 'Henzinger MH. 2000. Web information retrieval - an algorithmic perspective.
    8th Annual European Symposium on Algorithms. ESA: European Symposium on Algorithms,
    LNCS, vol. 1879, 1–8.'
  mla: Henzinger, Monika H. “Web Information Retrieval - an Algorithmic Perspective.”
    <i>8th Annual European Symposium on Algorithms</i>, vol. 1879, Springer Nature,
    2000, pp. 1–8, doi:<a href="https://doi.org/10.1007/3-540-45253-2_1">10.1007/3-540-45253-2_1</a>.
  short: M.H. Henzinger, in:, 8th Annual European Symposium on Algorithms, Springer
    Nature, 2000, pp. 1–8.
conference:
  end_date: 2000-09-08
  location: Saarbrücken, Germany
  name: 'ESA: European Symposium on Algorithms'
  start_date: 2000-09-05
date_created: 2022-08-11T13:25:07Z
date_published: 2000-09-01T00:00:00Z
date_updated: 2023-02-13T12:08:21Z
day: '01'
doi: 10.1007/3-540-45253-2_1
extern: '1'
intvolume: '      1879'
language:
- iso: eng
month: '09'
oa_version: None
page: 1–8
publication: 8th Annual European Symposium on Algorithms
publication_identifier:
  eisbn:
  - '9783540452539'
  eissn:
  - 1611-3349
  isbn:
  - '9783540410041'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Web information retrieval - an algorithmic perspective
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1879
year: '2000'
...
---
_id: '11893'
abstract:
- lang: eng
  text: "We present fully dynamic algorithms for maintaining the biconnected components
    in general and plane graphs.\r\n\r\nA fully dynamic algorithm maintains a graph
    during a sequence of insertions and deletions of edges or isolated vertices. Let
    m be the number of edges and n be the number of vertices in a graph. The time
    per operation of the best deterministic algorithms is \U0001D442(\U0001D45B√)
    in general graphs and O(log n) in plane graphs for fully dynamic connectivity
    and O(min m2/3 ,n}) in general graphs and \U0001D442(\U0001D45B√) in plane graphs
    for fully dynamic biconnectivity. We improve the later running times to \U0001D442(\U0001D45Alog\U0001D45B‾‾‾‾‾‾‾√)
    in general graphs and O(log 2n ) in plane graphs. Our algorithm for general graphscan
    also find the biconnected components of all vertices in time O(n)."
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
citation:
  ama: Henzinger MH. Improved data structures for fully dynamic biconnectivity. <i>SIAM
    Journal on Computing</i>. 2000;29(6):1761-1815. doi:<a href="https://doi.org/10.1137/s0097539794263907">10.1137/s0097539794263907</a>
  apa: Henzinger, M. H. (2000). Improved data structures for fully dynamic biconnectivity.
    <i>SIAM Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics.
    <a href="https://doi.org/10.1137/s0097539794263907">https://doi.org/10.1137/s0097539794263907</a>
  chicago: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
    <i>SIAM Journal on Computing</i>. Society for Industrial &#38; Applied Mathematics,
    2000. <a href="https://doi.org/10.1137/s0097539794263907">https://doi.org/10.1137/s0097539794263907</a>.
  ieee: M. H. Henzinger, “Improved data structures for fully dynamic biconnectivity,”
    <i>SIAM Journal on Computing</i>, vol. 29, no. 6. Society for Industrial &#38;
    Applied Mathematics, pp. 1761–1815, 2000.
  ista: Henzinger MH. 2000. Improved data structures for fully dynamic biconnectivity.
    SIAM Journal on Computing. 29(6), 1761–1815.
  mla: Henzinger, Monika H. “Improved Data Structures for Fully Dynamic Biconnectivity.”
    <i>SIAM Journal on Computing</i>, vol. 29, no. 6, Society for Industrial &#38;
    Applied Mathematics, 2000, pp. 1761–815, doi:<a href="https://doi.org/10.1137/s0097539794263907">10.1137/s0097539794263907</a>.
  short: M.H. Henzinger, SIAM Journal on Computing 29 (2000) 1761–1815.
date_created: 2022-08-17T08:45:41Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-02-17T14:39:47Z
day: '01'
doi: 10.1137/s0097539794263907
extern: '1'
intvolume: '        29'
issue: '6'
language:
- iso: eng
month: '11'
oa_version: None
page: 1761-1815
publication: SIAM Journal on Computing
publication_identifier:
  eissn:
  - 1095-7111
  issn:
  - 0097-5397
publication_status: published
publisher: Society for Industrial & Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Improved data structures for fully dynamic biconnectivity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2000'
...
---
_id: '2325'
alternative_title:
- Contemporary Mathematics
author:
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: 'Seiringer R. Inequalities for Schrödinger operators and applications to the
    stability of matter problem . In: Vol 529. American Mathematical Society; 2000:53-72.
    doi:<a href="https://doi.org/10.1090/conm/529">10.1090/conm/529</a>'
  apa: Seiringer, R. (2000). Inequalities for Schrödinger operators and applications
    to the stability of matter problem  (Vol. 529, pp. 53–72). Presented at the Arizona
    School of Analysis With Applications, American Mathematical Society. <a href="https://doi.org/10.1090/conm/529">https://doi.org/10.1090/conm/529</a>
  chicago: Seiringer, Robert. “Inequalities for Schrödinger Operators and Applications
    to the Stability of Matter Problem ,” 529:53–72. American Mathematical Society,
    2000. <a href="https://doi.org/10.1090/conm/529">https://doi.org/10.1090/conm/529</a>.
  ieee: R. Seiringer, “Inequalities for Schrödinger operators and applications to
    the stability of matter problem ,” presented at the Arizona School of Analysis
    With Applications, 2000, vol. 529, pp. 53–72.
  ista: Seiringer R. 2000. Inequalities for Schrödinger operators and applications
    to the stability of matter problem . Arizona School of Analysis With Applications,
    Contemporary Mathematics, vol. 529, 53–72.
  mla: Seiringer, Robert. <i>Inequalities for Schrödinger Operators and Applications
    to the Stability of Matter Problem </i>. Vol. 529, American Mathematical Society,
    2000, pp. 53–72, doi:<a href="https://doi.org/10.1090/conm/529">10.1090/conm/529</a>.
  short: R. Seiringer, in:, American Mathematical Society, 2000, pp. 53–72.
conference:
  name: Arizona School of Analysis With Applications
date_created: 2018-12-11T11:57:00Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:47Z
day: '01'
doi: 10.1090/conm/529
extern: 1
intvolume: '       529'
month: '01'
page: 53 - 72
publication_status: published
publisher: American Mathematical Society
publist_id: '4602'
quality_controlled: 0
status: public
title: 'Inequalities for Schrödinger operators and applications to the stability of
  matter problem '
type: conference
volume: 529
year: '2000'
...
---
_id: '2342'
abstract:
- lang: eng
  text: In the theoretical description of recent experiments with dilute Bose gases
    confined in external potentials the Gross-Pitaevskii equation plays an important
    role. Its status as an approximation for the quantum mechanical many-body ground
    state problem has recently been rigorously clarified. A summary of this work is
    presented here.
article_processing_charge: No
arxiv: 1
author:
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Élliott
  full_name: Lieb, Élliott
  last_name: Lieb
- first_name: Jakob
  full_name: Yngvason, Jakob
  last_name: Yngvason
citation:
  ama: 'Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting
    bosons in a trap. In: <i>Proceedings of the International Symposium on Quantum
    Theory and Symmetries</i>. World Scientific Publishing; 2000:101-110.'
  apa: Seiringer, R., Lieb, É., &#38; Yngvason, J. (2000). The ground state energy
    and density of interacting bosons in a trap. In <i>Proceedings of the International
    Symposium on Quantum Theory and Symmetries</i> (pp. 101–110). World Scientific
    Publishing.
  chicago: Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State
    Energy and Density of Interacting Bosons in a Trap.” In <i>Proceedings of the
    International Symposium on Quantum Theory and Symmetries</i>, 101–10. World Scientific
    Publishing, 2000.
  ieee: R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density
    of interacting bosons in a trap,” in <i>Proceedings of the International Symposium
    on Quantum Theory and Symmetries</i>, 2000, pp. 101–110.
  ista: 'Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density
    of interacting bosons in a trap. Proceedings of the International Symposium on
    Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.'
  mla: Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting
    Bosons in a Trap.” <i>Proceedings of the International Symposium on Quantum Theory
    and Symmetries</i>, World Scientific Publishing, 2000, pp. 101–10.
  short: R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International
    Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000,
    pp. 101–110.
conference:
  name: 'ISQTS: Quantum Theory and Symmetries'
date_created: 2018-12-11T11:57:06Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-03T13:00:35Z
day: '01'
extern: '1'
external_id:
  arxiv:
  - math-ph/9911026
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/9911026
month: '06'
oa: 1
oa_version: None
page: 101 - 110
publication: Proceedings of the International Symposium on Quantum Theory and Symmetries
publication_identifier:
  isbn:
  - '9789810242374 '
publication_status: published
publisher: World Scientific Publishing
publist_id: '4584'
quality_controlled: '1'
status: public
title: The ground state energy and density of interacting bosons in a trap
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '2343'
abstract:
- lang: eng
  text: We study the energy levels of a single particle in a homogeneous magnetic
    field and in an axially symmetric external potential. For potentials that are
    superharmonic off the central axis, we find a general 'pseudoconcave' ordering
    of the ground state energies of the Hamiltonian restricted to the sectors with
    fixed angular momentum. The physical applications include atoms and ions in strong
    magnetic fields. There the energies are monotone increasing and concave in angular
    momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends
    to the entire lowest band of Bloch functions.
author:
- first_name: Bernhard
  full_name: Baumgartner, Bernhard
  last_name: Baumgartner
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous
    magnetic fields. <i>Letters in Mathematical Physics</i>. 2000;54(3):213-226. doi:<a
    href="https://doi.org/    10.1023/A:1010978807635">    10.1023/A:1010978807635</a>
  apa: Baumgartner, B., &#38; Seiringer, R. (2000). On the ordering of energy levels
    in homogeneous magnetic fields. <i>Letters in Mathematical Physics</i>. Springer.
    <a href="https://doi.org/    10.1023/A:1010978807635">https://doi.org/    10.1023/A:1010978807635</a>
  chicago: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy
    Levels in Homogeneous Magnetic Fields.” <i>Letters in Mathematical Physics</i>.
    Springer, 2000. <a href="https://doi.org/    10.1023/A:1010978807635">https://doi.org/ 
      10.1023/A:1010978807635</a>.
  ieee: B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous
    magnetic fields,” <i>Letters in Mathematical Physics</i>, vol. 54, no. 3. Springer,
    pp. 213–226, 2000.
  ista: Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous
    magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.
  mla: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels
    in Homogeneous Magnetic Fields.” <i>Letters in Mathematical Physics</i>, vol.
    54, no. 3, Springer, 2000, pp. 213–26, doi:<a href="https://doi.org/    10.1023/A:1010978807635"> 
      10.1023/A:1010978807635</a>.
  short: B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.
date_created: 2018-12-11T11:57:06Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2021-01-12T06:56:54Z
day: '01'
doi: '    10.1023/A:1010978807635'
extern: 1
intvolume: '        54'
issue: '3'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0011031
month: '11'
oa: 1
page: 213 - 226
publication: Letters in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4582'
quality_controlled: 0
status: public
title: On the ordering of energy levels in homogeneous magnetic fields
type: journal_article
volume: 54
year: '2000'
...
---
_id: '2344'
abstract:
- lang: eng
  text: The ground-state properties of interacting Bose gases in external potentials,
    as considered in recent experiments, are usually described by means of the Gross-Pitaevskii
    energy functional. We present here a rigorous proof of the asymptotic exactness
    of this approximation for the ground-state energy and particle density of a dilute
    Bose gas with a positive interaction.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Élliott
  full_name: Lieb, Élliott
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Jakob
  full_name: Yngvason, Jakob
  last_name: Yngvason
citation:
  ama: 'Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of
    the Gross-Pitaevskii energy functional. <i>Physical Review A - Atomic, Molecular,
    and Optical Physics</i>. 2000;61(4):436021-4360213. doi:<a href="https://doi.org/10.1103/PhysRevA.61.043602">10.1103/PhysRevA.61.043602</a>'
  apa: 'Lieb, É., Seiringer, R., &#38; Yngvason, J. (2000). Bosons in a trap: A rigorous
    derivation of the Gross-Pitaevskii energy functional. <i>Physical Review A - Atomic,
    Molecular, and Optical Physics</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevA.61.043602">https://doi.org/10.1103/PhysRevA.61.043602</a>'
  chicago: 'Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap:
    A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” <i>Physical
    Review A - Atomic, Molecular, and Optical Physics</i>. American Physical Society,
    2000. <a href="https://doi.org/10.1103/PhysRevA.61.043602">https://doi.org/10.1103/PhysRevA.61.043602</a>.'
  ieee: 'É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation
    of the Gross-Pitaevskii energy functional,” <i>Physical Review A - Atomic, Molecular,
    and Optical Physics</i>, vol. 61, no. 4. American Physical Society, pp. 436021–4360213,
    2000.'
  ista: 'Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation
    of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular,
    and Optical Physics. 61(4), 436021–4360213.'
  mla: 'Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii
    Energy Functional.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>,
    vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:<a href="https://doi.org/10.1103/PhysRevA.61.043602">10.1103/PhysRevA.61.043602</a>.'
  short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular,
    and Optical Physics 61 (2000) 436021–4360213.
date_created: 2018-12-11T11:57:07Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-03T12:47:08Z
day: '01'
doi: 10.1103/PhysRevA.61.043602
extern: '1'
external_id:
  arxiv:
  - math-ph/9908027
intvolume: '        61'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/9908027
month: '04'
oa: 1
oa_version: Published Version
page: 436021 - 4360213
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_identifier:
  issn:
  - 0556-2791
publication_status: published
publisher: American Physical Society
publist_id: '4583'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '2000'
...
---
_id: '2418'
abstract:
- lang: eng
  text: For an absolutely continuous probability measure μ on Rd and a nonnegative
    integer k, let sk(μ, 0) denote the probability that the convex hull of k+d+1 random
    points which are i.i.d. according to μ contains the origin 0. For d and k given,
    we determine a tight upper bound on sk(μ, 0), and we characterize the measures
    in Rd which attain this bound. This result can be considered a continuous analogue
    of the Upper Bound Theorem for the maximal number of faces of convex polytopes
    with a given number of vertices. For our proof we introduce so-called h-functions,
    continuous counterparts of h-vectors for simplicial convex polytopes.
article_processing_charge: No
author:
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
- first_name: Emo
  full_name: Welzl, Emo
  last_name: Welzl
citation:
  ama: 'Wagner U, Welzl E. Origin-embracing distributions or a continuous analogue
    of the Upper Bound Theorem. In: <i>Proceedings of the 16th Annual Symposium on
    Computational Geometry</i>. ACM; 2000:50-56. doi:<a href="https://doi.org/10.1145/336154.336176">10.1145/336154.336176</a>'
  apa: 'Wagner, U., &#38; Welzl, E. (2000). Origin-embracing distributions or a continuous
    analogue of the Upper Bound Theorem. In <i>Proceedings of the 16th annual symposium
    on Computational geometry</i> (pp. 50–56). Clear Water Bay Kowloon, Hong Kong:
    ACM. <a href="https://doi.org/10.1145/336154.336176">https://doi.org/10.1145/336154.336176</a>'
  chicago: Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous
    Analogue of the Upper Bound Theorem.” In <i>Proceedings of the 16th Annual Symposium
    on Computational Geometry</i>, 50–56. ACM, 2000. <a href="https://doi.org/10.1145/336154.336176">https://doi.org/10.1145/336154.336176</a>.
  ieee: U. Wagner and E. Welzl, “Origin-embracing distributions or a continuous analogue
    of the Upper Bound Theorem,” in <i>Proceedings of the 16th annual symposium on
    Computational geometry</i>, Clear Water Bay Kowloon, Hong Kong, 2000, pp. 50–56.
  ista: 'Wagner U, Welzl E. 2000. Origin-embracing distributions or a continuous analogue
    of the Upper Bound Theorem. Proceedings of the 16th annual symposium on Computational
    geometry. SCG: Symposium on Computational Geometry, 50–56.'
  mla: Wagner, Uli, and Emo Welzl. “Origin-Embracing Distributions or a Continuous
    Analogue of the Upper Bound Theorem.” <i>Proceedings of the 16th Annual Symposium
    on Computational Geometry</i>, ACM, 2000, pp. 50–56, doi:<a href="https://doi.org/10.1145/336154.336176">10.1145/336154.336176</a>.
  short: U. Wagner, E. Welzl, in:, Proceedings of the 16th Annual Symposium on Computational
    Geometry, ACM, 2000, pp. 50–56.
conference:
  end_date: 2000-04-14
  location: Clear Water Bay Kowloon, Hong Kong
  name: 'SCG: Symposium on Computational Geometry'
  start_date: 2000-06-12
date_created: 2018-12-11T11:57:33Z
date_published: 2000-05-01T00:00:00Z
date_updated: 2023-05-03T12:41:02Z
day: '01'
doi: 10.1145/336154.336176
extern: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 50 - 56
publication: Proceedings of the 16th annual symposium on Computational geometry
publication_identifier:
  isbn:
  - '9781581132243'
publication_status: published
publisher: ACM
publist_id: '4507'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Origin-embracing distributions or a continuous analogue of the Upper Bound
  Theorem
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '2494'
abstract:
- lang: eng
  text: 'This chapter focuses on metabotropic glutamate receptors (mGluRs). These
    receptors are linked to several intracellular signal transduction mechanisms via
    G-protein and are implicated in diverse functions of the mammalian central nervous
    system (CNS). These functions include mediation of slow excitatory and inhibitory
    responses; regulation of calcium channels, potassium channels, and non-selective
    cation channels; inhibition and facilitation of transmitter release; induction
    of long-term potentiation and long-term depression; and regulation of neuronal
    development. Functional diversity of the metabotropic glutamate receptor is reflected
    in molecular diversity of receptor subtypes. The sites of action of mGluRs are
    widely found throughout different membrane compartments of neuronal and glial
    cells. The chapter reviews the differential subcellular localization of metabotropic
    glutamate receptors in relation to transmitter release sites. Patterns of subcellular
    localization of mGluRs are different among three subgroups: group I and III mGluRs
    are mainly localized to somatodendritic and axonal domains of neurons, respectively,
    while group II mGluRs are extensively localized to both domains as well as to
    glial cell processes.'
alternative_title:
- Handbook of Chemical Neuroanatomy
article_processing_charge: No
author:
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
citation:
  ama: 'Shigemoto R, Mizuno N. Chapter III Metabotropic glutamate receptors - immunocytochemical
    and in situ hybridization analyses. In: <i>Glutamate</i>. Vol 18. Elsevier; 2000:63-98.
    doi:<a href="https://doi.org/10.1016/S0924-8196(00)80044-5">10.1016/S0924-8196(00)80044-5</a>'
  apa: Shigemoto, R., &#38; Mizuno, N. (2000). Chapter III Metabotropic glutamate
    receptors - immunocytochemical and in situ hybridization analyses. In <i>Glutamate</i>
    (Vol. 18, pp. 63–98). Elsevier. <a href="https://doi.org/10.1016/S0924-8196(00)80044-5">https://doi.org/10.1016/S0924-8196(00)80044-5</a>
  chicago: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
    Receptors - Immunocytochemical and in Situ Hybridization Analyses.” In <i>Glutamate</i>,
    18:63–98. Elsevier, 2000. <a href="https://doi.org/10.1016/S0924-8196(00)80044-5">https://doi.org/10.1016/S0924-8196(00)80044-5</a>.
  ieee: R. Shigemoto and N. Mizuno, “Chapter III Metabotropic glutamate receptors
    - immunocytochemical and in situ hybridization analyses,” in <i>Glutamate</i>,
    vol. 18, Elsevier, 2000, pp. 63–98.
  ista: 'Shigemoto R, Mizuno N. 2000.Chapter III Metabotropic glutamate receptors
    - immunocytochemical and in situ hybridization analyses. In: Glutamate. Handbook
    of Chemical Neuroanatomy, vol. 18, 63–98.'
  mla: Shigemoto, Ryuichi, and Noboru Mizuno. “Chapter III Metabotropic Glutamate
    Receptors - Immunocytochemical and in Situ Hybridization Analyses.” <i>Glutamate</i>,
    vol. 18, Elsevier, 2000, pp. 63–98, doi:<a href="https://doi.org/10.1016/S0924-8196(00)80044-5">10.1016/S0924-8196(00)80044-5</a>.
  short: R. Shigemoto, N. Mizuno, in:, Glutamate, Elsevier, 2000, pp. 63–98.
date_created: 2018-12-11T11:58:00Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-03T12:27:40Z
day: '01'
doi: 10.1016/S0924-8196(00)80044-5
extern: '1'
intvolume: '        18'
language:
- iso: eng
month: '01'
oa_version: None
page: 63 - 98
publication: Glutamate
publication_identifier:
  eissn:
  - 0924-8196
publication_status: published
publisher: Elsevier
publist_id: '4407'
quality_controlled: '1'
status: public
title: Chapter III Metabotropic glutamate receptors - immunocytochemical and in situ
  hybridization analyses
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '2000'
...
---
_id: '2598'
abstract:
- lang: eng
  text: "There are many types of cerebellar ataxia, including ataxia due to congenital
    or metabolic disorders and a paraneoplastic form in patients with gynecologic
    cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic
    syndrome is the only type of cerebellar ataxia associated with autoantibodies
    against neuronal antigens. Often, the neuronal antigens are aberrantly expressed
    by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar
    ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the
    ataxia by months to years in 80 percent of patients, and ataxia often occurs during
    a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent
    have anti–Purkinje-cell antibodies, some of which have the features of the neuronal
    antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with
    severe cerebellar ataxia that developed while they were in remission from Hodgkin's
    disease. The antibody reacts specifically with the metabotropic glutamate receptor
    mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family
    of cell-surface receptors that transmit signals into the cell by coupling to guanine
    nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the
    serum of both patients blocked the glutamate-stimulated formation of inositol
    phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the
    injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid
    space of mice caused severe, reversible ataxia. These results indicate that antineuronal
    autoantibodies can cause disease of the central nervous system by blocking neuronal
    receptors."
acknowledgement: "Supported in part by the Ministry of Education, Science, and Culture
  of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology
  Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr.
  De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw
  and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to
  the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to
  T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful
  discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C.
  Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E.
  Koekkoek, K.J. Reus, and C. Vermeer for technical assistance."
article_processing_charge: No
article_type: original
author:
- first_name: Peter
  full_name: Sillevis Smitt, Peter
  last_name: Sillevis Smitt
- first_name: Ayae
  full_name: Kinoshita, Ayae
  last_name: Kinoshita
- first_name: Bertie
  full_name: De Leeuw, Bertie
  last_name: De Leeuw
- first_name: Wiebe
  full_name: Moll, Wiebe
  last_name: Moll
- first_name: Michiel
  full_name: Coesmans, Michiel
  last_name: Coesmans
- first_name: Dick
  full_name: Jaarsma, Dick
  last_name: Jaarsma
- first_name: Sonja
  full_name: Henzen Logmans, Sonja
  last_name: Henzen Logmans
- first_name: Charles
  full_name: Vecht, Charles
  last_name: Vecht
- first_name: Chris
  full_name: De Zeeuw, Chris
  last_name: De Zeeuw
- first_name: Naotaka
  full_name: Sekiyama, Naotaka
  last_name: Sekiyama
- first_name: Shigetada
  full_name: Nakanishi, Shigetada
  last_name: Nakanishi
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar
    ataxia due to autoantibodies against a glutamate receptor. <i>New England Journal
    of Medicine</i>. 2000;342(1):21-27. doi:<a href="https://doi.org/10.1056/NEJM200001063420104">10.1056/NEJM200001063420104</a>
  apa: Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma,
    D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies
    against a glutamate receptor. <i>New England Journal of Medicine</i>. Massachussetts
    Medical Society. <a href="https://doi.org/10.1056/NEJM200001063420104">https://doi.org/10.1056/NEJM200001063420104</a>
  chicago: Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel
    Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar
    Ataxia Due to Autoantibodies against a Glutamate Receptor.” <i>New England Journal
    of Medicine</i>. Massachussetts Medical Society, 2000. <a href="https://doi.org/10.1056/NEJM200001063420104">https://doi.org/10.1056/NEJM200001063420104</a>.
  ieee: P. Sillevis Smitt <i>et al.</i>, “Paraneoplastic cerebellar ataxia due to
    autoantibodies against a glutamate receptor,” <i>New England Journal of Medicine</i>,
    vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.
  ista: Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D,
    Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000.
    Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor.
    New England Journal of Medicine. 342(1), 21–27.
  mla: Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies
    against a Glutamate Receptor.” <i>New England Journal of Medicine</i>, vol. 342,
    no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:<a href="https://doi.org/10.1056/NEJM200001063420104">10.1056/NEJM200001063420104</a>.
  short: P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma,
    S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto,
    New England Journal of Medicine 342 (2000) 21–27.
date_created: 2018-12-11T11:58:35Z
date_published: 2000-01-06T00:00:00Z
date_updated: 2023-05-03T11:14:19Z
day: '06'
doi: 10.1056/NEJM200001063420104
extern: '1'
external_id:
  pmid:
  - '10620645'
intvolume: '       342'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.nejm.org/doi/full/10.1056/nejm200001063420104
month: '01'
oa: 1
oa_version: None
page: 21 - 27
pmid: 1
publication: New England Journal of Medicine
publication_identifier:
  issn:
  - 0028-4793
publication_status: published
publisher: Massachussetts Medical Society
publist_id: '4300'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate
  receptor
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 342
year: '2000'
...
---
_id: '2599'
abstract:
- lang: eng
  text: 'The synaptic relationship between substance P (SP) and its receptor, i.e.,
    neurokinin-1 receptor (NK1R), was examined in the striatum of the rat by confocal
    laser-scanning microscopy and electron microscopy. For confocal laser-scanning
    microscopy, triple-immunofluorescence histochemistry was performed to label NK1R,
    SP, and vesicular acetylcholine transporter (a specific marker for cholinergic
    neurons). In electron microscopic double- immunolabeling study, immunoreactivity
    for NK1R was detected with the silver- intensified gold method, while immunoreactivity
    for SP was detected with peroxidase immunohistochemistry. Simultaneous immunolabeling
    of NK1R and SP revealed significant mismatch at the synaptic level: although some
    SP- immunopositive axon terminals were in synaptic contact with NK1R- immunopositive
    sites of plasma membrane, NK1R-immunoreactivity was observed at both synaptic
    and non-synaptic sites of plasma membrane. Thus, SP released from the sites remote
    from NK1Rs might diffuse in the extracellular fluid to act, as a paracrine neurotransmitter,
    on NK1Rs distant from its releasing site. SP neurotransmission in the striatum
    might occur not only synaptically but also extrasynaptically. The SP-NK1R system
    might constitute an association system within the striatum.'
acknowledgement: The  authors  are  grateful  for  the  photographic  help  of Ms.  Yue-Ping  Yuan,  Mr.  Akira  Uesugi,  Ms.  Keiko  Oka-moto,
  Mr. Nobuyuki Kobayashi, and Mr. Hideki Itabashi. The authors also express their
  gratitudes for the support of Dr. Kajitaro Morita in Morita Clinic of Internal Medicine
  and Pediatrics, Kadoma, Osaka, Japan
article_processing_charge: No
article_type: original
author:
- first_name: Jin
  full_name: Li, Jin
  last_name: Li
- first_name: Dan
  full_name: Wang, Dan
  last_name: Wang
- first_name: Takeshi
  full_name: Kaneko, Takeshi
  last_name: Kaneko
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Sakashi
  full_name: Nomura, Sakashi
  last_name: Nomura
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
citation:
  ama: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. Relationship between
    neurokinin-1 receptor and substance P in the striatum: Light and electron microscopic
    immunohistochemical study in the rat. <i>Journal of Comparative Neurology</i>.
    2000;418(2):156-163. doi:<a href="https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z">10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>'
  apa: 'Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., &#38; Mizuno, N.
    (2000). Relationship between neurokinin-1 receptor and substance P in the striatum:
    Light and electron microscopic immunohistochemical study in the rat. <i>Journal
    of Comparative Neurology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z">https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>'
  chicago: 'Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura,
    and Noboru Mizuno. “Relationship between Neurokinin-1 Receptor and Substance P
    in the Striatum: Light and Electron Microscopic Immunohistochemical Study in the
    Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 2000. <a href="https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z">https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>.'
  ieee: 'J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “Relationship
    between neurokinin-1 receptor and substance P in the striatum: Light and electron
    microscopic immunohistochemical study in the rat,” <i>Journal of Comparative Neurology</i>,
    vol. 418, no. 2. Wiley-Blackwell, pp. 156–163, 2000.'
  ista: 'Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. Relationship
    between neurokinin-1 receptor and substance P in the striatum: Light and electron
    microscopic immunohistochemical study in the rat. Journal of Comparative Neurology.
    418(2), 156–163.'
  mla: 'Li, Jin, et al. “Relationship between Neurokinin-1 Receptor and Substance
    P in the Striatum: Light and Electron Microscopic Immunohistochemical Study in
    the Rat.” <i>Journal of Comparative Neurology</i>, vol. 418, no. 2, Wiley-Blackwell,
    2000, pp. 156–63, doi:<a href="https://doi.org/10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z">10.1002/(SICI)1096-9861(20000306)418:2&#38;lt;156::AID-CNE3&#38;gt;3.0.CO;2-Z</a>.'
  short: J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Journal of
    Comparative Neurology 418 (2000) 156–163.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-03-06T00:00:00Z
date_updated: 2023-05-03T10:56:44Z
day: '06'
doi: 10.1002/(SICI)1096-9861(20000306)418:2&lt;156::AID-CNE3&gt;3.0.CO;2-Z
extern: '1'
external_id:
  pmid:
  - '10701441'
intvolume: '       418'
issue: '2'
language:
- iso: eng
month: '03'
oa_version: None
page: 156 - 163
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
  issn:
  - 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4299'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Relationship between neurokinin-1 receptor and substance P in the striatum:
  Light and electron microscopic immunohistochemical study in the rat'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 418
year: '2000'
...
