---
_id: '4473'
abstract:
- lang: eng
text: 'The simulation preorder on state transition systems is widely accepted as
a useful notion of refinement, both in its own right and as an efficiently checkable
sufficient condition for trace containment. For composite systems, due to the
exponential explosion of the state space, there is a need for decomposing a simulation
check of the form P ≤s Q, denoting "P is simulated by Q," into simpler
simulation checks on the components of P and Q. We present an assume-guarantee
rule that enables such a decomposition. To the best of our knowledge, this is
the first assume-guarantee rule that applies to a refinement relation different
from trace containment. Our rule is circular, and its soundness proof requires
induction on trace trees. The proof is constructive: given simulation relations
that witness the simulation preorder between corresponding components of P and
Q, we provide a procedure for constructing a witness relation for P ≤s Q. We also
extend our assume-guarantee rule to account for fairness constraints on transition
systems.'
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Shaz
full_name: Qadeer, Shaz
last_name: Qadeer
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
- first_name: Serdar
full_name: Tasiran, Serdar
last_name: Tasiran
citation:
ama: Henzinger TA, Qadeer S, Rajamani S, Tasiran S. An assume-guarantee rule for
checking simulation. ACM Transactions on Programming Languages and Systems
(TOPLAS). 2002;24(1):51-64. doi:10.1145/509705.509707
apa: Henzinger, T. A., Qadeer, S., Rajamani, S., & Tasiran, S. (2002). An assume-guarantee
rule for checking simulation. ACM Transactions on Programming Languages and
Systems (TOPLAS). ACM. https://doi.org/10.1145/509705.509707
chicago: Henzinger, Thomas A, Shaz Qadeer, Sriram Rajamani, and Serdar Tasiran.
“An Assume-Guarantee Rule for Checking Simulation.” ACM Transactions on Programming
Languages and Systems (TOPLAS). ACM, 2002. https://doi.org/10.1145/509705.509707.
ieee: T. A. Henzinger, S. Qadeer, S. Rajamani, and S. Tasiran, “An assume-guarantee
rule for checking simulation,” ACM Transactions on Programming Languages and
Systems (TOPLAS), vol. 24, no. 1. ACM, pp. 51–64, 2002.
ista: Henzinger TA, Qadeer S, Rajamani S, Tasiran S. 2002. An assume-guarantee rule
for checking simulation. ACM Transactions on Programming Languages and Systems
(TOPLAS). 24(1), 51–64.
mla: Henzinger, Thomas A., et al. “An Assume-Guarantee Rule for Checking Simulation.”
ACM Transactions on Programming Languages and Systems (TOPLAS), vol. 24,
no. 1, ACM, 2002, pp. 51–64, doi:10.1145/509705.509707.
short: T.A. Henzinger, S. Qadeer, S. Rajamani, S. Tasiran, ACM Transactions on Programming
Languages and Systems (TOPLAS) 24 (2002) 51–64.
date_created: 2018-12-11T12:09:02Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-05T07:59:47Z
day: '01'
doi: 10.1145/509705.509707
extern: '1'
intvolume: ' 24'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 51 - 64
publication: ACM Transactions on Programming Languages and Systems (TOPLAS)
publication_identifier:
issn:
- 0164-0925
publication_status: published
publisher: ACM
publist_id: '256'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An assume-guarantee rule for checking simulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 24
year: '2002'
...
---
_id: '4474'
abstract:
- lang: eng
text: 'The simulation preorder for labeled transition systems is defined locally,
and operationally, as a game that relates states with their immediate successor
states. Simulation enjoys many appealing properties. First, simulation has a denotational
characterization: system S simulates system I iff every computation tree embedded
in the unrolling of I can be embedded also in the unrolling of S. Second, simulation
has a logical characterization: S simulates I iff every universal branching-time
formula satisfied by S is satisfied also by I. It follows that simulation is a
suitable notion of implementation, and it is the coarsest abstraction of a system
that preserves universal branching-time properties. Third, based on its local
definition, simulation between finite-state systems can be checked in polynomial
time. Finally, simulation implies trace containment, which cannot be defined locally
and requires polynomial space for verification. Hence simulation is widely used
both in manual and in automatic verification. Liveness assumptions about transition
systems are typically modeled using fairness constraints. Existing notions of
simulation for fair transition systems, however, are not local, and as a result,
many appealing properties of the simulation preorder are lost. We propose a new
view of fair simulation by extending the local definition of simulation to account
for fairness: system View the MathML sourcefairly simulates system View the MathML
source iff in the simulation game, there is a strategy that matches with each
fair computation of View the MathML source a fair computation of View the MathML
source. Our definition enjoys a denotational characterization and has a logical
characterization: View the MathML source fairly simulates View the MathML source
iff every fair computation tree (whose infinite paths are fair) embedded in the
unrolling of View the MathML source can be embedded also in the unrolling of View
the MathML source or, equivalently, iff every Fair-∀AFMC formula satisfied by
View the MathML source is satisfied also by View the MathML source (∀AFMC is the
universal fragment of the alternation-free μ-calculus). The locality of the definition
leads us to a polynomial-time algorithm for checking fair simulation for finite-state
systems with weak and strong fairness constraints. Finally, fair simulation implies
fair trace containment and is therefore useful as an efficiently computable local
criterion for proving linear-time abstraction hierarchies of fair systems.'
acknowledgement: We thank Ramin Hojati, Doron Bustan, and the anonymous reviewers
for their comments on this paper.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
- first_name: Sriram
full_name: Rajamani, Sriram
last_name: Rajamani
citation:
ama: Henzinger TA, Kupferman O, Rajamani S. Fair simulation. Information and
Computation. 2002;173(1):64-81. doi:10.1006/inco.2001.3085
apa: Henzinger, T. A., Kupferman, O., & Rajamani, S. (2002). Fair simulation.
Information and Computation. Elsevier. https://doi.org/10.1006/inco.2001.3085
chicago: Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.”
Information and Computation. Elsevier, 2002. https://doi.org/10.1006/inco.2001.3085.
ieee: T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” Information
and Computation, vol. 173, no. 1. Elsevier, pp. 64–81, 2002.
ista: Henzinger TA, Kupferman O, Rajamani S. 2002. Fair simulation. Information
and Computation. 173(1), 64–81.
mla: Henzinger, Thomas A., et al. “Fair Simulation.” Information and Computation,
vol. 173, no. 1, Elsevier, 2002, pp. 64–81, doi:10.1006/inco.2001.3085.
short: T.A. Henzinger, O. Kupferman, S. Rajamani, Information and Computation 173
(2002) 64–81.
date_created: 2018-12-11T12:09:02Z
date_published: 2002-02-25T00:00:00Z
date_updated: 2023-06-05T07:53:27Z
day: '25'
doi: 10.1006/inco.2001.3085
extern: '1'
intvolume: ' 173'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0890540101930858?via%3Dihub
month: '02'
oa: 1
oa_version: Published Version
page: 64 - 81
publication: Information and Computation
publication_identifier:
issn:
- 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '255'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair simulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 173
year: '2002'
...
---
_id: '4476'
abstract:
- lang: eng
text: 'One approach to model checking software is based on the abstract-check-refine
paradigm: build an abstract model, then check the desired property, and if the
check fails, refine the model and start over. We introduce the concept of lazy
abstraction to integrate and optimize the three phases of the abstract-check-refine
loop. Lazy abstraction continuously builds and refines a single abstract model
on demand, driven by the model checker, so that different parts of the model may
exhibit different degrees of precision, namely just enough to verify the desired
property. We present an algorithm for model checking safety properties using lazy
abstraction and describe an implementation of the algorithm applied to C programs.
We also provide sufficient conditions for the termination of the method.'
acknowledgement: "We thank Wes Weimer and Jeff Foster for many useful discussions.
\r\n"
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ranjit
full_name: Jhala, Ranjit
last_name: Jhala
- first_name: Ritankar
full_name: Majumdar, Ritankar
last_name: Majumdar
- first_name: Grégoire
full_name: Sutre, Grégoire
last_name: Sutre
citation:
ama: 'Henzinger TA, Jhala R, Majumdar R, Sutre G. Lazy abstraction. In: Proceedings
of the 29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages.
ACM; 2002:58-70. doi:10.1145/503272.503279'
apa: 'Henzinger, T. A., Jhala, R., Majumdar, R., & Sutre, G. (2002). Lazy abstraction.
In Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming
languages (pp. 58–70). Portland, OR, USA: ACM. https://doi.org/10.1145/503272.503279'
chicago: Henzinger, Thomas A, Ranjit Jhala, Ritankar Majumdar, and Grégoire Sutre.
“Lazy Abstraction.” In Proceedings of the 29th ACM SIGPLAN-SIGACT Symposium
on Principles of Programming Languages, 58–70. ACM, 2002. https://doi.org/10.1145/503272.503279.
ieee: T. A. Henzinger, R. Jhala, R. Majumdar, and G. Sutre, “Lazy abstraction,”
in Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming
languages, Portland, OR, USA, 2002, pp. 58–70.
ista: 'Henzinger TA, Jhala R, Majumdar R, Sutre G. 2002. Lazy abstraction. Proceedings
of the 29th ACM SIGPLAN-SIGACT symposium on Principles of programming languages.
POPL: Principles of Programming Languages, 58–70.'
mla: Henzinger, Thomas A., et al. “Lazy Abstraction.” Proceedings of the 29th
ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, ACM,
2002, pp. 58–70, doi:10.1145/503272.503279.
short: T.A. Henzinger, R. Jhala, R. Majumdar, G. Sutre, in:, Proceedings of the
29th ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages, ACM,
2002, pp. 58–70.
conference:
end_date: 2002-01-18
location: Portland, OR, USA
name: 'POPL: Principles of Programming Languages'
start_date: 2002-01-16
date_created: 2018-12-11T12:09:03Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-05T07:45:53Z
day: '01'
doi: 10.1145/503272.503279
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 58 - 70
publication: Proceedings of the 29th ACM SIGPLAN-SIGACT symposium on Principles of
programming languages
publication_identifier:
isbn:
- '9781581134506'
publication_status: published
publisher: ACM
publist_id: '254'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lazy abstraction
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2604'
abstract:
- lang: eng
text: Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena
that occur in neurogenic inflammation, are partially blocked by substance P (SP)
receptor antagonists and are known to be mediated in part by mast cell-released
substances, such as histamine, serotonin, and nitric oxide. In an attempt to provide
a morphological substrate for the above phenomena, we applied light and electron
microscopic immunocytochemistry to investigate the pattern of SP innervation of
blood vessels and its relationship to mast cells in the skin of the rat lower
lip. Furthermore, we examined the distribution of SP (neurokinin-1) receptors
and their relationship to SP-immunoreactive (IR) fibers. Our results confirmed
that SP-IR fibers are found in cutaneous nerves and that terminal branches are
observed around blood vessels and penetrating the epidermis. SP-IR fibers also
innervated hair follicles and sebaceous glands. At the ultrastructural level,
SP-IR varicosities were observed adjacent to arterioles, capillaries, venules,
and mast cells. The varicosities possessed both dense core vesicles and agranular
synaptic vesicles. We quantified the distance between SP-IR varicosities and blood
vessel endothelial cells. SP-IR terminals were located within 0.23-5.99 μm from
the endothelial cell layer in 82.7% of arterioles, in 90.2% of capillaries, and
in 86.9% of venules. Although there was a trend for SP-IR fibers to be located
closer to the endothelium of venules, this difference was not significant. Neurokinin-1
receptor (NK-1r) immunoreactivity was most abundant in the upper dermis and was
associated with the wall of blood vessels. NK-1r were located in equal amounts
on the walls of arterioles, capillaries, and venules that were innervated by SP-IR
fibers. The present results favor the concept of a participation of SP in cutaneous
neurogenic vasodilatation and plasma extravasation both by an action on blood
vessels after binding to the NK-1r and by causing the release of substances from
mast cells after diffusion through the connective tissue.
acknowledgement: This work was sponsored by grant MT-12170 from the Canadian Medical
Research Council. The authors thank Marie Ballak for electron microscopy assistance,
Alan Forster for photographic expertise, and Sid Parkinson for editorial
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Light and electron microscopic
study of the distribution of substance P-immunoreactive fibers and neurokinin-1
receptors in the skin of the rat lower lip. Journal of Comparative Neurology.
2001;432(4):466-480. doi:10.1002/cne.1114
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Light
and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip. Journal
of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.1114
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Light and Electron Microscopic Study of the Distribution of Substance
P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of the Rat Lower
Lip.” Journal of Comparative Neurology. Wiley-Blackwell, 2001. https://doi.org/10.1002/cne.1114.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip,” Journal of Comparative
Neurology, vol. 432, no. 4. Wiley-Blackwell, pp. 466–480, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Light and electron
microscopic study of the distribution of substance P-immunoreactive fibers and
neurokinin-1 receptors in the skin of the rat lower lip. Journal of Comparative
Neurology. 432(4), 466–480.
mla: Ruocco, Isabella, et al. “Light and Electron Microscopic Study of the Distribution
of Substance P-Immunoreactive Fibers and Neurokinin-1 Receptors in the Skin of
the Rat Lower Lip.” Journal of Comparative Neurology, vol. 432, no. 4,
Wiley-Blackwell, 2001, pp. 466–80, doi:10.1002/cne.1114.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Journal of Comparative
Neurology 432 (2001) 466–480.
date_created: 2018-12-11T11:58:37Z
date_published: 2001-04-16T00:00:00Z
date_updated: 2023-05-24T13:03:51Z
day: '16'
doi: 10.1002/cne.1114
extern: '1'
external_id:
pmid:
- '11268009'
intvolume: ' 432'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 466 - 480
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4294'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light and electron microscopic study of the distribution of substance P-immunoreactive
fibers and neurokinin-1 receptors in the skin of the rat lower lip
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 432
year: '2001'
...
---
_id: '2605'
abstract:
- lang: eng
text: 'The granular layer of the cerebellar cortex consists of densely packed neuronal
cells, classified into granule cells and large interneurons. In this study, we
provide a comparative survey of large granular layer interneurons in the adult
rat cerebellum based on both morphological and neurochemical criteria. To this
end, double immunofluorescence histochemistry was performed by combining antibodies
against the cytoplasmic antigen Rat-303, calretinin, the metabotropic glutamate
receptor mGluR2 and somatostatin. Based on Rat-303/calretinin double immunohistochemistry,
three distinct populations of large granular layer interneurons could be discerned:
cells immunopositive for Rat-303, calretinin or both. Rat-303 or calretinin single-labeled
cells represented Golgi cells and unipolar brush cells, respectively. Rat-303/calretinin
double-labeled cells located just underneath the Purkinje cell layer represented
Lugaro cells. Morphometrical analysis distinguished two populations of Rat-303-positive
Golgi cells according to their location: vermis versus hemisphere. Immunostaining
for the metabotropic glutamate receptor mGluR2 combined with Rat-303 or calretinin
revealed that the majority of Golgi cells (about 90%) appeared to be mGluR2 positive.
Lugaro cells were mGluR2 negative. In addition, a limited population of large
polymorphous interneurons in the depth of the granular layer with morphological
features resembling Golgi cells also displayed Rat-303/calretinin immunoreactivity
and were mGluR2 negative. Double immunohistochemistry for Rat-303 and somatostatin
revealed three populations of labeled cells in the depth of the granular layer.
Besides double-labeled Golgi cells, Rat-303 or somatostatin single-labeled cells
were present. Based on mGluR2/somatostatin and calretinin/somatostatin double
immunostainings, Rat-303 single-labeled cells were found to correspond to Rat-303/calretinin-positive,
mGluR2-negative Golgi-like cells, while the identity of somatostatin single-labeled
cells remained unclear. The data presented in this article elaborate previous
reports on the morphological and neurochemical differentiation of large interneurons
in the rat cerebellar granular layer. In addition, they indicate that the current
classification of these cells into Golgi cells, Lugaro cells and unipolar brush
cells does not describe the observed neurochemical heterogeneity.'
article_processing_charge: No
article_type: original
author:
- first_name: Frederik
full_name: Geurts, Frederik
last_name: Geurts
- first_name: Jean
full_name: Timmermans, Jean
last_name: Timmermans
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Erik
full_name: De Schutter, Erik
last_name: De Schutter
citation:
ama: Geurts F, Timmermans J, Shigemoto R, De Schutter E. Morphological and neurochemical
differentiation of large granular layer interneurons in the adult rat cerebellum.
Neuroscience. 2001;104(2):499-512. doi:10.1016/S0306-4522(01)00058-6
apa: Geurts, F., Timmermans, J., Shigemoto, R., & De Schutter, E. (2001). Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00058-6
chicago: Geurts, Frederik, Jean Timmermans, Ryuichi Shigemoto, and Erik De Schutter.
“Morphological and Neurochemical Differentiation of Large Granular Layer Interneurons
in the Adult Rat Cerebellum.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00058-6.
ieee: F. Geurts, J. Timmermans, R. Shigemoto, and E. De Schutter, “Morphological
and neurochemical differentiation of large granular layer interneurons in the
adult rat cerebellum,” Neuroscience, vol. 104, no. 2. Elsevier, pp. 499–512,
2001.
ista: Geurts F, Timmermans J, Shigemoto R, De Schutter E. 2001. Morphological and
neurochemical differentiation of large granular layer interneurons in the adult
rat cerebellum. Neuroscience. 104(2), 499–512.
mla: Geurts, Frederik, et al. “Morphological and Neurochemical Differentiation of
Large Granular Layer Interneurons in the Adult Rat Cerebellum.” Neuroscience,
vol. 104, no. 2, Elsevier, 2001, pp. 499–512, doi:10.1016/S0306-4522(01)00058-6.
short: F. Geurts, J. Timmermans, R. Shigemoto, E. De Schutter, Neuroscience 104
(2001) 499–512.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-05-10T00:00:00Z
date_updated: 2023-05-24T12:45:30Z
day: '10'
doi: 10.1016/S0306-4522(01)00058-6
extern: '1'
external_id:
pmid:
- '11377850'
intvolume: ' 104'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 499 - 512
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4292'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Morphological and neurochemical differentiation of large granular layer interneurons
in the adult rat cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 104
year: '2001'
...
---
_id: '2606'
abstract:
- lang: eng
text: Glutamate receptors have been linked to the regulation of several developmental
events in the CNS. By using cortical slices of early postnatal mice, we show that
in layer I cells, glutamate produces intracellular calcium ([Ca2+]i) elevations
mediated by ionotropic and metabotropic glutamate receptors (mGluRs). The contribution
of mGluRs to these responses was demonstrated by application of tACPD, an agonist
to groups I and II mGluRs, which evoked [Ca2+]i increases that could be reversibly
blocked by MCPG, an antagonist to groups I and II mGluRs. In the absence of extracellular
Ca2+, repetitive applications of tACPD or quisqualate, an agonist to group I mGluRs,
elicited decreasing [Ca2+]i responses that were restored by refilling a thapsigargin-sensitive
Ca2+ store. The use of specific group I mGluR agonists CHPG and DHPG indicated
that the functional mGluR in layer I was of the mGluR1 subtype. Subtype specific
antibodies confirmed the presence of mGlur1α, but not mGluR5, in Cajal-Retzius
(Reelin-immunoreactive) neurons.
acknowledgement: MV and AF are senior coauthors of this work, which was supported by
Ministerio de Educacion y Cultura, grants SAF97/0195 and SAF 2000-0152-C02-02 to
M.V; PB94-0219-CO2-01 and PB97-0582-CO2-01 to A.F., Accio Especial de R+D AE98-18 from Generalitat Valenciana, and a Fellowship
from Bancaixa-C.S.I.C. to J.R.M.-G. We wish to thank Andre M. Goffinet for his G10 antireelin antibody and Roberto Gallego, Juan M. Luque and Felix
Viana for their constructive criticisms on previous versions of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Galán
full_name: Martínez, Galán
last_name: Martínez
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Miguel
full_name: Valdeolmillos, Miguel
last_name: Valdeolmillos
citation:
ama: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors. European Journal of Neuroscience. 2001;13(6):1147-1154.
doi:10.1046/j.0953-816X.2001.01494.x
apa: Martínez, G., López Bendito, G., Luján, R., Shigemoto, R., Fairén, A., &
Valdeolmillos, M. (2001). Cajal-Retzius cells in early postnatal mouse cortex
selectively express functional metabotropic glutamate receptors. European Journal
of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816X.2001.01494.x
chicago: Martínez, Galán, Guillermina López Bendito, Rafael Luján, Ryuichi Shigemoto,
Alfonso Fairén, and Miguel Valdeolmillos. “Cajal-Retzius Cells in Early Postnatal
Mouse Cortex Selectively Express Functional Metabotropic Glutamate Receptors.”
European Journal of Neuroscience. Wiley-Blackwell, 2001. https://doi.org/10.1046/j.0953-816X.2001.01494.x.
ieee: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, and M. Valdeolmillos,
“Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors,” European Journal of Neuroscience, vol.
13, no. 6. Wiley-Blackwell, pp. 1147–1154, 2001.
ista: Martínez G, López Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos
M. 2001. Cajal-Retzius cells in early postnatal mouse cortex selectively express
functional metabotropic glutamate receptors. European Journal of Neuroscience.
13(6), 1147–1154.
mla: Martínez, Galán, et al. “Cajal-Retzius Cells in Early Postnatal Mouse Cortex
Selectively Express Functional Metabotropic Glutamate Receptors.” European
Journal of Neuroscience, vol. 13, no. 6, Wiley-Blackwell, 2001, pp. 1147–54,
doi:10.1046/j.0953-816X.2001.01494.x.
short: G. Martínez, G. López Bendito, R. Luján, R. Shigemoto, A. Fairén, M. Valdeolmillos,
European Journal of Neuroscience 13 (2001) 1147–1154.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-24T12:53:46Z
day: '01'
doi: 10.1046/j.0953-816X.2001.01494.x
extern: '1'
external_id:
pmid:
- '11285012'
intvolume: ' 13'
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 1147 - 1154
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4293'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cajal-Retzius cells in early postnatal mouse cortex selectively express functional
metabotropic glutamate receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...
---
_id: '2607'
abstract:
- lang: eng
text: Alternative splicing in the mGluR5 gene generates two different receptor isoforms,
of which expression is developmentally regulated. However, little is known about
the functional significance of mGluR5 splice variants. We have examined the functional
coupling, subcellular targeting, and effect on neuronal differentiation of epitope-tagged
mGluR5 isoforms by expression in neuroblastoma NG108-15 cells. We found that both
mGluR5 splice variants give rise to comparable [Ca2+]i transients and have similar
pharmacological profile. Tagged receptors were shown by immunofluorescence to
be inserted in the plasma membrane. In undifferentiated cells the subcellular
localization of the two mGluR5 isoforms was partially segregated, whereas in differentiated
cells the labeling largely redistributed to the newly formed neurites. Interestingly,
we demonstrate that mGluR5 splice variants dramatically influence the formation
and maturation of neurites; mGluR5a hinders the acquisition of mature neuronal
traits and mGluR5b fosters the elaboration and extension of neurites. These effects
are partly inhibited by MPEP.
acknowledgement: "The authors thank: Dr. J. M. Rimland and M. T. Scupoli for their
technical help with X. oocytes recordings and FAC sorting, respectively; Dr. Y.
Dalezios for helping with the statistical analyses; and Dr. G. Varani for helping
with the analyses of mRNA and genomic sequences. We are also grateful to Professor
F. Benfenati, Dr. F. Conquet, Dr. Rafael Lujan, Dr. J. McIlhinney, Professor P.
Somogyi, Dr. J. H. Xuereb, and Dr. M. Zoli for careful reading of the manuscript\r\nand
helpful suggestions. R.S. is supported by the Laboratory of Cerebral Structure,
National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST
Japan Science and Technology Corporation, Japan."
article_processing_charge: No
article_type: original
author:
- first_name: Silvia
full_name: Mion, Silvia
last_name: Mion
- first_name: Corrado
full_name: Corti, Corrado
last_name: Corti
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Mauro
full_name: Corsi, Mauro
last_name: Corsi
- first_name: Guido
full_name: Fumagalli, Guido
last_name: Fumagalli
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Mion S, Corti C, Neki A, et al. Bidirectional regulation of neurite elaboration
by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms.
Molecular and Cellular Neuroscience. 2001;17(6):957-972. doi:10.1006/mcne.2001.0993
apa: Mion, S., Corti, C., Neki, A., Shigemoto, R., Corsi, M., Fumagalli, G., &
Ferraguti, F. (2001). Bidirectional regulation of neurite elaboration by alternatively
spliced metabotropic glutamate receptor 5 (mGluR5) isoforms. Molecular and
Cellular Neuroscience. Academic Press. https://doi.org/10.1006/mcne.2001.0993
chicago: Mion, Silvia, Corrado Corti, Akio Neki, Ryuichi Shigemoto, Mauro Corsi,
Guido Fumagalli, and Francesco Ferraguti. “Bidirectional Regulation of Neurite
Elaboration by Alternatively Spliced Metabotropic Glutamate Receptor 5 (MGluR5)
Isoforms.” Molecular and Cellular Neuroscience. Academic Press, 2001. https://doi.org/10.1006/mcne.2001.0993.
ieee: S. Mion et al., “Bidirectional regulation of neurite elaboration by
alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms,” Molecular
and Cellular Neuroscience, vol. 17, no. 6. Academic Press, pp. 957–972, 2001.
ista: Mion S, Corti C, Neki A, Shigemoto R, Corsi M, Fumagalli G, Ferraguti F. 2001.
Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms. Molecular and Cellular Neuroscience. 17(6),
957–972.
mla: Mion, Silvia, et al. “Bidirectional Regulation of Neurite Elaboration by Alternatively
Spliced Metabotropic Glutamate Receptor 5 (MGluR5) Isoforms.” Molecular and
Cellular Neuroscience, vol. 17, no. 6, Academic Press, 2001, pp. 957–72, doi:10.1006/mcne.2001.0993.
short: S. Mion, C. Corti, A. Neki, R. Shigemoto, M. Corsi, G. Fumagalli, F. Ferraguti,
Molecular and Cellular Neuroscience 17 (2001) 957–972.
date_created: 2018-12-11T11:58:38Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-24T09:34:13Z
day: '01'
doi: 10.1006/mcne.2001.0993
extern: '1'
external_id:
pmid:
- '11414786'
intvolume: ' 17'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 957 - 972
pmid: 1
publication: Molecular and Cellular Neuroscience
publication_identifier:
issn:
- 1044-7431
publication_status: published
publisher: Academic Press
publist_id: '4291'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic
glutamate receptor 5 (mGluR5) isoforms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '2001'
...
---
_id: '2608'
abstract:
- lang: eng
text: The regulation of neurotransmitter receptors during synapse formation has
been studied extensively at the neuromuscular junction, but little is known about
the development of excitatory neurotransmitter receptors during synaptogenesis
in central synapses. In this study we show qualitatively and quantitatively that
a receptor undergoes changes in localisation on the surface of rat Purkinje cells
during development in association with its excitatory synapses. The presence of
mGluR1α at parallel and climbing fibre synapses on developing Purkinje cells was
studied using high-resolution immunoelectron microscopy. Immunoreactivity for
mGluR1α was detected from embryonic day 18 in Purkinje cells, and showed dramatic
changes in its localisation with age. At early postnatal ages (P0 and P3), mGluR1α
was found both in somata and stem dendrites but was not usually associated with
synaptic contacts. At P7, mGluR1α became concentrated in somatic spines associated
with climbing fibres and in the growing dendritic arborisation even before innervation
by parallel fibres. During the second and third postnatal week, when spines and
parallel fibre synapses were generated, mGluR1α became progressively concentrated
in the molecular layer, particularly in the synaptic specialisations. As a result,
during the fourth postnatal week, the pattern and level of mGluR1α expression
became similar to the adult and mGluR1α appeared in high density in perisynaptic
sites. Our results indicate that mGluR1α is present in the developing Purkinje
cells prior to their innervation by climbing and parallel fibres and demonstrate
that this receptor undergoes a dynamic and specific regulation during postnatal
development in association with the establishment of synaptic inputs to Purkinje
cell.
acknowledgement: öWe thank Drs. Paul Bolam, Ole Paulsen, Je¡ McIlhinney, Alfonso Faire¨n
and Francisco Ciruela for reviewing a previous version of this manuscript and Mrs
Alexandra Salewski for the English revision of the manuscript. We also want to thank
Dr. Peter Somogyi for offering the facilities of the MRC Anatomical Neuropharmacology
Unit to carry out part of this study. This work was supported by a Grant from the
European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministry of Education
(DGES PM 97-0082 to J.M.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: José
full_name: Juíz, José
last_name: Juíz
citation:
ama: López Bendito G, Shigemoto R, Luján R, Juíz J. Developmental changes in the
localisation of the mGluR1α subtype of metabotropic glutamate receptors in Purkinje
cells. Neuroscience. 2001;105(2):413-429. doi:10.1016/S0306-4522(01)00188-9
apa: López Bendito, G., Shigemoto, R., Luján, R., & Juíz, J. (2001). Developmental
changes in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00188-9
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Rafael Luján, and José Juíz.
“Developmental Changes in the Localisation of the MGluR1α Subtype of Metabotropic
Glutamate Receptors in Purkinje Cells.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00188-9.
ieee: G. López Bendito, R. Shigemoto, R. Luján, and J. Juíz, “Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells,” Neuroscience, vol. 105, no. 2. Elsevier, pp. 413–429,
2001.
ista: López Bendito G, Shigemoto R, Luján R, Juíz J. 2001. Developmental changes
in the localisation of the mGluR1α subtype of metabotropic glutamate receptors
in Purkinje cells. Neuroscience. 105(2), 413–429.
mla: López Bendito, Guillermina, et al. “Developmental Changes in the Localisation
of the MGluR1α Subtype of Metabotropic Glutamate Receptors in Purkinje Cells.”
Neuroscience, vol. 105, no. 2, Elsevier, 2001, pp. 413–29, doi:10.1016/S0306-4522(01)00188-9.
short: G. López Bendito, R. Shigemoto, R. Luján, J. Juíz, Neuroscience 105 (2001)
413–429.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-07-27T00:00:00Z
date_updated: 2023-05-24T09:31:48Z
day: '27'
doi: 10.1016/S0306-4522(01)00188-9
extern: '1'
external_id:
pmid:
- '11672608 '
intvolume: ' 105'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 413 - 429
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4290'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmental changes in the localisation of the mGluR1α subtype of metabotropic
glutamate receptors in Purkinje cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 105
year: '2001'
...
---
_id: '2609'
abstract:
- lang: eng
text: 'The metabotropic glutamate receptors (mGluRs) have distinct distribution
patterns in the CNS but subtypes within group I or group III mGluRs share similar
ultrastructural localization relative to neurotransmitter release sites: group
I mGluRs are concentrated in an annulus surrounding the edge of the postsynaptic
density, whereas group III mGluRs are concentrated in the presynaptic active zone.
One of the group II subtypes, mGluR2, is expressed in both pre- and postsynaptic
elements, having no close association with synapses. In order to determine if
such a distribution is common to another group II subtype, mGluR3, an antibody
was raised against a carboxy-terminus of mGluR3 and used for light and electron
microscopic immunohistochemistry in the mouse CNS. The antibody reacted strongly
with mGluR3, but it also reacted, though only weakly, with mGluR2. Therefore,
to examine mGluR3-selective distribution, we used mGluR2-deficient mice as well
as wild-type mice. Strong immunoreactivity for mGluR3 was found in the cerebral
cortex, striatum, dentate gyrus of the hippocampus, olfactory tubercle, lateral
septal nucleus, lateral and basolateral amygdaloid nuclei, and nucleus of the
lateral olfactory tract. Pre-embedding immunoperoxidase and immunogold methods
revealed mGluR3 labeling in both presynaptic and postsynaptic elements, and also
in glial profiles. Double labeling revealed that the vast majority of mGluR3 in
presynaptic elements is not closely associated with glutamate and GABA release
sites in the striatum and thalamus, respectively. However, in the spines of the
dentate granule cells, the highest receptor density was found in perisynaptic
sites (20% of immunogold particles within 60 nm from the edge of postsynaptic
membrane specialization) followed by a decreasing receptor density away from the
synapses (to ∼5% of particles per 60 nm). Furthermore, 19% of immunogold particles
were located in asymmetrical postsynaptic specialization, indicating an association
of mGluR3 to glutamatergic synapses. The present results indicate that the localization
of mGluR3 is rather similar to that of group I mGluRs in the postsynaptic elements,
suggesting a unique functional role of mGluR3 in glutamatergic neurotransmission
in the CNS.'
acknowledgement: We are grateful to M. Yokoi and S. Nakanishi for kindly providing
us with the mGluR2-de¢cient mice and F. Ferraguti for mGluR8b cDNA. The technical
assistance of S. Doi and the photographic assistance of A. Uesugi are acknowledged.
This work has been supported by research grants from the Ministry of Education,
Sports, Culture, Science, and Technology of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Y
full_name: Tamaru, Y
last_name: Tamaru
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. Distribution of metabotropic glutamate
receptor mGluR3 in the mouse CNS: Differential location relative to pre- and postsynaptic
sites. Neuroscience. 2001;106(3):481-503. doi:10.1016/S0306-4522(01)00305-0'
apa: 'Tamaru, Y., Nomura, S., Mizuno, N., & Shigemoto, R. (2001). Distribution
of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential location
relative to pre- and postsynaptic sites. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00305-0'
chicago: 'Tamaru, Y, Sakashi Nomura, Noboru Mizuno, and Ryuichi Shigemoto. “Distribution
of Metabotropic Glutamate Receptor MGluR3 in the Mouse CNS: Differential Location
Relative to Pre- and Postsynaptic Sites.” Neuroscience. Elsevier, 2001.
https://doi.org/10.1016/S0306-4522(01)00305-0.'
ieee: 'Y. Tamaru, S. Nomura, N. Mizuno, and R. Shigemoto, “Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites,” Neuroscience, vol. 106, no. 3. Elsevier,
pp. 481–503, 2001.'
ista: 'Tamaru Y, Nomura S, Mizuno N, Shigemoto R. 2001. Distribution of metabotropic
glutamate receptor mGluR3 in the mouse CNS: Differential location relative to
pre- and postsynaptic sites. Neuroscience. 106(3), 481–503.'
mla: 'Tamaru, Y., et al. “Distribution of Metabotropic Glutamate Receptor MGluR3
in the Mouse CNS: Differential Location Relative to Pre- and Postsynaptic Sites.”
Neuroscience, vol. 106, no. 3, Elsevier, 2001, pp. 481–503, doi:10.1016/S0306-4522(01)00305-0.'
short: Y. Tamaru, S. Nomura, N. Mizuno, R. Shigemoto, Neuroscience 106 (2001) 481–503.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-09-27T00:00:00Z
date_updated: 2023-05-24T08:51:17Z
day: '27'
doi: 10.1016/S0306-4522(01)00305-0
extern: '1'
external_id:
pmid:
- '11591452'
intvolume: ' 106'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 481 - 503
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: Differential
location relative to pre- and postsynaptic sites'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 106
year: '2001'
...
---
_id: '2610'
abstract:
- lang: eng
text: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination
to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After
the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype,
we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals
aged 12 weeks and older, subthreshold doses of these drugs induced seizures in
mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by
three standard anticonvulsant drugs, but not by the group III selective mGluR
agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs
of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed
no major changes in synaptic properties in two slice preparations. However, slightly
increased excitability was evident in hippocampal slices. In addition, there was
slower recovery from frequency facilitation in cortical slices, suggesting a role
for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings
suggest that mGluR7 receptors have a unique role in regulating neuronal excitability
and that these receptors may be a novel target for the development of anticonvulsant
drugs.
acknowledgement: This work was supported in part by the Biotechnology and Biological
Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg
for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8
cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination
of brain sections, Christoph Wiessner for help with plots and statistics, Valerie
Schuler for help with Western blots, and the team of the Novartis special strain
breeding facility for their support.
article_processing_charge: No
article_type: original
author:
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Trevor
full_name: Bushell, Trevor
last_name: Bushell
- first_name: Vernon
full_name: Clarke, Vernon
last_name: Clarke
- first_name: Andrei
full_name: Rozov, Andrei
last_name: Rozov
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Chantal
full_name: Portet, Chantal
last_name: Portet
- first_name: Fabrizio
full_name: Gasparini, Fabrizio
last_name: Gasparini
- first_name: Markus
full_name: Schmutz, Markus
last_name: Schmutz
- first_name: Klaus
full_name: Klebs, Klaus
last_name: Klebs
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Rainer
full_name: Kühn, Rainer
last_name: Kühn
- first_name: Thomas
full_name: Knoepfel, Thomas
last_name: Knoepfel
- first_name: Markus
full_name: Schroeder, Markus
last_name: Schroeder
- first_name: David
full_name: Hampson, David
last_name: Hampson
- first_name: Valerie
full_name: Collett, Valerie
last_name: Collett
- first_name: Congxiao
full_name: Zhang, Congxiao
last_name: Zhang
- first_name: Robert
full_name: Duvoisin, Robert
last_name: Duvoisin
- first_name: Graham
full_name: Collingridge, Graham
last_name: Collingridge
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
citation:
ama: Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice
lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745.
doi:10.1523/JNEUROSCI.21-22-08734.2001
apa: Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C.,
… Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001
chicago: Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev,
Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in
Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience.
Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001.
ieee: G. Sansig et al., “Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no.
22. Society for Neuroscience, pp. 8734–8745, 2001.
ista: Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F,
Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson
D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased
seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal
of Neuroscience. 21(22), 8734–8745.
mla: Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic
Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society
for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001.
short: G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini,
M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder,
D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten,
Journal of Neuroscience 21 (2001) 8734–8745.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-11-15T00:00:00Z
date_updated: 2023-05-24T08:47:53Z
day: '15'
doi: 10.1523/JNEUROSCI.21-22-08734.2001
extern: '1'
external_id:
pmid:
- '11698585'
intvolume: ' 21'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/
month: '11'
oa: 1
oa_version: Published Version
page: 8734 - 8745
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4288'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor
7
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '2611'
abstract:
- lang: eng
text: Research using animal models of neuropathic pain has revealed sympathetic
sprouting onto dorsal root ganglion cells. More recently, sensory fibre sprouting
onto dorsal root ganglion cells has also been observed. Previous work in our laboratory
demonstrated persistent sympathetic fibre sprouting in the skin of the rat lower
lip following sensory denervation of this region. Therefore, we applied immunocytochemistry
to determine the effects of sympathectomies on the terminal fields of sensory
fibres. The superior cervical ganglia were removed bilaterally and the effects
on the innervation of the skin of the rat lower lip were observed 1, 2, 3, 4,
6 and 8 weeks post-surgery. Substance P and dopamine-β-hydroxylase immunoreactivities
were used to identify a subset of sensory and sympathetic fibres, respectively.
We also assessed neurokinin-1 receptor immunoreactivity. Quantitative data was
obtained with the aid of an image analysis system. In controls, the epidermis
and upper dermis were innervated by substance P-immunoreactive fibres only and
upper dermal blood vessels possessed the highest density of neurokinin-1 receptor
immunoreactivity. Blood vessels in the lower dermis were innervated by both substance
P- and dopamine-β-hydroxylase-immunoreactive fibres. Following sympathectomies,
substance P-immunoreactive fibres in the epidermis and upper dermis were more
intensely labelled only 1 and 2 weeks post-surgery when compared to sham controls.
The length of substance P-immunoreactive fibres in this region was also increased
only on the second week. Neurokinin-1 receptor immunoreactivity in the upper dermis
was slightly decreased 1 and 2 weeks post-surgery. In the lower dermis, substance
P-immunoreactive fibres associated with blood vessels were more intensely labelled
only 1 and 2 weeks post-surgery, and at all post-surgical time points studied,
blood vessels in this region were devoid of dopamine-β-hydroxylase-immunoreactive
fibres. The length of substance P-immunoreactive fibres was increased from the
first to the third week post-surgery in the lower dermis. These results indicate
that sympathectomies lead to transient changes in substance P-immunoreactive fibre
innervation and neurokinin-1 receptor expression in rat lower lip skin. The effects
are most prominent in the lower dermis probably due to a greater local concentration
of nerve growth factor in this region. The plasticity of the interactions between
sensory and sympathetic fibres may prove important in the regulation of skin microcirculation
and in the generation of painful sensations under normal conditions or following
peripheral nerve injuries.
acknowledgement: 'The work contained in this manuscript was sponsored by the Canadian
MRC, Grants # MT-12170 and MoP-38093. The authors would like to thank Sylvain Cote
for technical assistance and Sid Parkinson for editorial assistance.'
article_processing_charge: No
article_type: original
author:
- first_name: Isabella
full_name: Ruocco, Isabella
last_name: Ruocco
- first_name: Augusto
full_name: Cuello, Augusto
last_name: Cuello
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
citation:
ama: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. Sympathectomies lead to
transient substance P-immunoreactive sensory fibre plasticity in the rat skin.
Neuroscience. 2001;108(1):157-166. doi:10.1016/S0306-4522(01)00158-0
apa: Ruocco, I., Cuello, A., Shigemoto, R., & Ribeiro Da Silva, A. (2001). Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(01)00158-0
chicago: Ruocco, Isabella, Augusto Cuello, Ryuichi Shigemoto, and Alfredo Ribeiro
Da Silva. “Sympathectomies Lead to Transient Substance P-Immunoreactive Sensory
Fibre Plasticity in the Rat Skin.” Neuroscience. Elsevier, 2001. https://doi.org/10.1016/S0306-4522(01)00158-0.
ieee: I. Ruocco, A. Cuello, R. Shigemoto, and A. Ribeiro Da Silva, “Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin,” Neuroscience, vol. 108, no. 1. Elsevier, pp. 157–166, 2001.
ista: Ruocco I, Cuello A, Shigemoto R, Ribeiro Da Silva A. 2001. Sympathectomies
lead to transient substance P-immunoreactive sensory fibre plasticity in the rat
skin. Neuroscience. 108(1), 157–166.
mla: Ruocco, Isabella, et al. “Sympathectomies Lead to Transient Substance P-Immunoreactive
Sensory Fibre Plasticity in the Rat Skin.” Neuroscience, vol. 108, no.
1, Elsevier, 2001, pp. 157–66, doi:10.1016/S0306-4522(01)00158-0.
short: I. Ruocco, A. Cuello, R. Shigemoto, A. Ribeiro Da Silva, Neuroscience 108
(2001) 157–166.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-12-05T00:00:00Z
date_updated: 2023-05-22T12:15:44Z
day: '05'
doi: 10.1016/S0306-4522(01)00158-0
extern: '1'
external_id:
pmid:
- '11738139'
intvolume: ' 108'
issue: '1'
language:
- iso: eng
month: '12'
oa_version: None
page: 157 - 166
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
publist_id: '4286'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sympathectomies lead to transient substance P-immunoreactive sensory fibre
plasticity in the rat skin
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '2001'
...
---
_id: '2612'
abstract:
- lang: eng
text: 'We examined immunoreactivities for γ-aminobutyric acidB-receptor (GABABR)
subtypes, GABABR1 and GABABR2, in the mesencephalic trigeminal nucleus neurons
(MTN neurons) of the rat. Immunoreactivity for GABABR1 was prominent in cell bodies
of MTN, whereas that for GABABR2 was very weak, if existed. For electron microscopy,
the immunogold-silver method for GABABR1 was combined with the immunoperoxidase
method for glutamic acid decarboxylase (GAD: the synthetic enzyme of GABA). Immunogold-silver
particles indicating GABABR1 immunoreactivity were distributed widely in the cytoplasm
of the cell bodies postsynaptic to GAD-immunoreactive axon terminals, but were
rarely associated with synaptic membrane specialization or extrasynaptic sites
of plasma membrane. It has been indicated that GABABR1 may not be transported
to plasma membrane when no GABABR2 exists. Thus, it was presumed that GABABR1
in the cell body of the rat MTN neurons might not be involved in the synaptic
transmission.'
acknowledgement: This work was supported in part by Grants-in-Aid from the National
Natural Science Foundation of China (39870262, 39970239), from the Foundation for
University Key Teacher of the Ministry of Education of China, and from the Ministry
of Education, Science, Sports, Culture and Technology of Japan (12308039, 12680743).
article_processing_charge: No
article_type: original
author:
- first_name: Jin
full_name: Li, Jin
last_name: Li
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Peng
full_name: Chen, Peng
last_name: Chen
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Li J, Shigemoto R, Kulik Á, et al. Immunocytochemical localization of GABAB
receptors in mesencephalic trigeminal nucleus neurons in the rat. Neuroscience
Letters. 2001;315(1-2):93-97. doi:10.1016/S0304-3940(01)02321-7
apa: Li, J., Shigemoto, R., Kulik, Á., Chen, P., Nomura, S., Kaneko, T., & Mizuno,
N. (2001). Immunocytochemical localization of GABAB receptors in mesencephalic
trigeminal nucleus neurons in the rat. Neuroscience Letters. Elsevier.
https://doi.org/10.1016/S0304-3940(01)02321-7
chicago: Li, Jin, Ryuichi Shigemoto, Ákos Kulik, Peng Chen, Sakashi Nomura, Takeshi
Kaneko, and Noboru Mizuno. “Immunocytochemical Localization of GABAB Receptors
in Mesencephalic Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters.
Elsevier, 2001. https://doi.org/10.1016/S0304-3940(01)02321-7.
ieee: J. Li et al., “Immunocytochemical localization of GABAB receptors in
mesencephalic trigeminal nucleus neurons in the rat,” Neuroscience Letters,
vol. 315, no. 1–2. Elsevier, pp. 93–97, 2001.
ista: Li J, Shigemoto R, Kulik Á, Chen P, Nomura S, Kaneko T, Mizuno N. 2001. Immunocytochemical
localization of GABAB receptors in mesencephalic trigeminal nucleus neurons in
the rat. Neuroscience Letters. 315(1–2), 93–97.
mla: Li, Jin, et al. “Immunocytochemical Localization of GABAB Receptors in Mesencephalic
Trigeminal Nucleus Neurons in the Rat.” Neuroscience Letters, vol. 315,
no. 1–2, Elsevier, 2001, pp. 93–97, doi:10.1016/S0304-3940(01)02321-7.
short: J. Li, R. Shigemoto, Á. Kulik, P. Chen, S. Nomura, T. Kaneko, N. Mizuno,
Neuroscience Letters 315 (2001) 93–97.
date_created: 2018-12-11T11:58:40Z
date_published: 2001-11-23T00:00:00Z
date_updated: 2023-05-22T12:30:05Z
day: '23'
doi: 10.1016/S0304-3940(01)02321-7
extern: '1'
external_id:
pmid:
- '11711223'
intvolume: ' 315'
issue: 1-2
language:
- iso: eng
month: '11'
oa_version: None
page: 93 - 97
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4287'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunocytochemical localization of GABAB receptors in mesencephalic trigeminal
nucleus neurons in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 315
year: '2001'
...
---
_id: '2709'
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Long time dynamics of an electron in a weakly coupled phonon field.
In: 13th International Congress of Mathematical Physics. International
Press of Boston; 2001:273-281.'
apa: Erdös, L. (2001). Long time dynamics of an electron in a weakly coupled phonon
field. In 13th International Congress of Mathematical Physics (pp. 273–281). International
Press of Boston.
chicago: Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon
Field.” In 13th International Congress of Mathematical Physics, 273–81. International
Press of Boston, 2001.
ieee: L. Erdös, “Long time dynamics of an electron in a weakly coupled phonon field,”
in 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–281.
ista: 'Erdös L. 2001.Long time dynamics of an electron in a weakly coupled phonon
field. In: 13th International Congress of Mathematical Physics. , 273–281.'
mla: Erdös, László. “Long Time Dynamics of an Electron in a Weakly Coupled Phonon
Field.” 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–81.
short: L. Erdös, in:, 13th International Congress of Mathematical Physics, International
Press of Boston, 2001, pp. 273–281.
date_created: 2018-12-11T11:59:11Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-22T12:11:29Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 273 - 281
publication: 13th International Congress of Mathematical Physics
publication_identifier:
isbn:
- '9781571460851'
publication_status: published
publisher: ' International Press of Boston'
publist_id: '4187'
quality_controlled: '1'
status: public
title: Long time dynamics of an electron in a weakly coupled phonon field
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2001'
...
---
_id: '2734'
abstract:
- lang: eng
text: In this paper we describe an intrinsically geometric way of producing magnetic
fields on S3 and R3 for which the corresponding Dirac operators have a non-trivial
kernel. In many cases we are able to compute the dimension of the kernel. In particular
we can give examples where the kernel has any given dimension. This generalizes
the examples of Loss and Yau [1].
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Erdös L, Solovej J. The kernel of Dirac operators on S3 and R3. Reviews
in Mathematical Physics. 2001;13(10):1247-1280. doi:10.1142/S0129055X01000983
apa: Erdös, L., & Solovej, J. (2001). The kernel of Dirac operators on S3 and
R3. Reviews in Mathematical Physics. World Scientific Publishing. https://doi.org/10.1142/S0129055X01000983
chicago: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and
R3.” Reviews in Mathematical Physics. World Scientific Publishing, 2001.
https://doi.org/10.1142/S0129055X01000983.
ieee: L. Erdös and J. Solovej, “The kernel of Dirac operators on S3 and R3,” Reviews
in Mathematical Physics, vol. 13, no. 10. World Scientific Publishing, pp.
1247–1280, 2001.
ista: Erdös L, Solovej J. 2001. The kernel of Dirac operators on S3 and R3. Reviews
in Mathematical Physics. 13(10), 1247–1280.
mla: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.”
Reviews in Mathematical Physics, vol. 13, no. 10, World Scientific Publishing,
2001, pp. 1247–80, doi:10.1142/S0129055X01000983.
short: L. Erdös, J. Solovej, Reviews in Mathematical Physics 13 (2001) 1247–1280.
date_created: 2018-12-11T11:59:19Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-05-16T12:24:25Z
day: '01'
doi: 10.1142/S0129055X01000983
extern: '1'
external_id:
arxiv:
- math-ph/0001036
intvolume: ' 13'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/math-ph/0001036
month: '10'
oa: 1
oa_version: Published Version
page: 1247 - 1280
publication: Reviews in Mathematical Physics
publication_identifier:
issn:
- 0129-055X
publication_status: published
publisher: World Scientific Publishing
publist_id: '4158'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The kernel of Dirac operators on S3 and R3
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2001'
...
---
_id: '2735'
abstract:
- lang: eng
text: We establish the exact low-energy asymptotics of the integrated density of
states (Lifschitz tail) in a homogeneous magnetic field and Poissonian impurities
with a repulsive single-site potential of Gaussian decay. It has been known that
the Gaussian potential tail discriminates between the so-called “classical” and
“quantum” regimes, and precise asymptotics are known in these cases. For the borderline
case, the coexistence of the classical and quantum regimes was conjectured. Here
we settle this last remaining open case to complete the full picture of the magnetic
Lifschitz tails.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Lifschitz tail in a magnetic field: Coexistence of classical and
quantum behavior in the borderline case. Probability Theory and Related Fields.
2001;121(2):219-236. doi:10.1007/PL00008803'
apa: 'Erdös, L. (2001). Lifschitz tail in a magnetic field: Coexistence of classical
and quantum behavior in the borderline case. Probability Theory and Related
Fields. Springer. https://doi.org/10.1007/PL00008803'
chicago: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical
and Quantum Behavior in the Borderline Case.” Probability Theory and Related
Fields. Springer, 2001. https://doi.org/10.1007/PL00008803.'
ieee: 'L. Erdös, “Lifschitz tail in a magnetic field: Coexistence of classical and
quantum behavior in the borderline case,” Probability Theory and Related Fields,
vol. 121, no. 2. Springer, pp. 219–236, 2001.'
ista: 'Erdös L. 2001. Lifschitz tail in a magnetic field: Coexistence of classical
and quantum behavior in the borderline case. Probability Theory and Related Fields.
121(2), 219–236.'
mla: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical
and Quantum Behavior in the Borderline Case.” Probability Theory and Related
Fields, vol. 121, no. 2, Springer, 2001, pp. 219–36, doi:10.1007/PL00008803.'
short: L. Erdös, Probability Theory and Related Fields 121 (2001) 219–236.
date_created: 2018-12-11T11:59:19Z
date_published: 2001-10-01T00:00:00Z
date_updated: 2023-05-16T12:20:42Z
day: '01'
doi: 10.1007/PL00008803
extern: '1'
external_id:
arxiv:
- math-ph/0003023
intvolume: ' 121'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/math-ph/0003023
month: '10'
oa: 1
oa_version: Published Version
page: 219 - 236
publication: Probability Theory and Related Fields
publication_identifier:
issn:
- 0044-3719
publication_status: published
publisher: Springer
publist_id: '4157'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior
in the borderline case'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 121
year: '2001'
...
---
_id: '2736'
abstract:
- lang: eng
text: We consider the time evolution of N bosonic particles interacting via a mean
field Coulomb potential. Suppose the initial state is a product wavefunction.
We show that at any finite time the correlation functions factorize in the limit
N → ∞. Furthermore, the limiting one particle density matrix satisfies the nonlinear
Hartree equation. The key ingredients are the uniqueness of the BBGKY hierarchy
for the correlation functions and a new apriori estimate for the many-body Schrödinger
equations.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Erdös L, Yau H. Derivation of the nonlinear Schrödinger equation from a many
body Coulomb system. Advances in Theoretical and Mathematical Physics.
2001;5(6):1169-1205. doi:10.48550/arXiv.math-ph/0111042
apa: Erdös, L., & Yau, H. (2001). Derivation of the nonlinear Schrödinger equation
from a many body Coulomb system. Advances in Theoretical and Mathematical Physics.
International Press. https://doi.org/10.48550/arXiv.math-ph/0111042
chicago: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger
Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical
Physics. International Press, 2001. https://doi.org/10.48550/arXiv.math-ph/0111042.
ieee: L. Erdös and H. Yau, “Derivation of the nonlinear Schrödinger equation from
a many body Coulomb system,” Advances in Theoretical and Mathematical Physics,
vol. 5, no. 6. International Press, pp. 1169–1205, 2001.
ista: Erdös L, Yau H. 2001. Derivation of the nonlinear Schrödinger equation from
a many body Coulomb system. Advances in Theoretical and Mathematical Physics.
5(6), 1169–1205.
mla: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation
from a Many Body Coulomb System.” Advances in Theoretical and Mathematical
Physics, vol. 5, no. 6, International Press, 2001, pp. 1169–205, doi:10.48550/arXiv.math-ph/0111042.
short: L. Erdös, H. Yau, Advances in Theoretical and Mathematical Physics 5 (2001)
1169–1205.
date_created: 2018-12-11T11:59:20Z
date_published: 2001-11-01T00:00:00Z
date_updated: 2023-05-16T12:12:41Z
day: '01'
doi: 10.48550/arXiv.math-ph/0111042
extern: '1'
external_id:
arxiv:
- math-ph/0111042
intvolume: ' 5'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0111042
month: '11'
oa: 1
oa_version: Published Version
page: 1169 - 1205
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
issn:
- 1095-0761
publication_status: published
publisher: International Press
publist_id: '4156'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Derivation of the nonlinear Schrödinger equation from a many body Coulomb system
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '2001'
...
---
_id: '2981'
abstract:
- lang: eng
text: Plants contain a novel unique subfamily of Rho GTPases, vital components of
cellular signalling networks. Here we report a general role for some members of
this family in polarized plant growth processes. We show that Arabidopsis AtRop4
and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates.
We localized AtRop proteins in root meristem cells to the cross-wall and cell
plate membranes. Polar localization of AtRops in trichoblasts specifies the growth
sites for emerging root hairs. These sites were visible before budding and elongation
of the Arabidopsis root hair when AtRops accumulated at their tips. Expression
of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic
Arabidopsis plants abolished polarized growth and delocalized the tip-focused
Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but
not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results
demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse
growth.
acknowledgement: We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars
Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the
manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work
was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98
0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient
of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Arthur
full_name: Molendijk, Arthur
last_name: Molendijk
- first_name: Friedrich
full_name: Bischoff, Friedrich
last_name: Bischoff
- first_name: Chadalavada
full_name: Rajendrakumar, Chadalavada
last_name: Rajendrakumar
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Markus
full_name: Braun, Markus
last_name: Braun
- first_name: Simon
full_name: Gilroy, Simon
last_name: Gilroy
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases
are localized to tips of root hairs and control polar growth. EMBO Journal.
2001;20(11):2779-2788. doi:10.1093/emboj/20.11.2779
apa: Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy,
S., & Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to
tips of root hairs and control polar growth. EMBO Journal. Wiley-Blackwell.
https://doi.org/10.1093/emboj/20.11.2779
chicago: Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří
Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop
GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO
Journal. Wiley-Blackwell, 2001. https://doi.org/10.1093/emboj/20.11.2779.
ieee: A. Molendijk et al., “Arabidopsis thaliana Rop GTPases are localized
to tips of root hairs and control polar growth,” EMBO Journal, vol. 20,
no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.
ista: Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme
K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs
and control polar growth. EMBO Journal. 20(11), 2779–2788.
mla: Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to
Tips of Root Hairs and Control Polar Growth.” EMBO Journal, vol. 20, no.
11, Wiley-Blackwell, 2001, pp. 2779–88, doi:10.1093/emboj/20.11.2779.
short: A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy,
K. Palme, EMBO Journal 20 (2001) 2779–2788.
date_created: 2018-12-11T12:00:40Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-16T12:07:45Z
day: '01'
doi: 10.1093/emboj/20.11.2779
extern: '1'
external_id:
pmid:
- '11387211'
intvolume: ' 20'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/
month: '06'
oa: 1
oa_version: Published Version
page: 2779 - 2788
pmid: 1
publication: EMBO Journal
publication_identifier:
issn:
- 0261-4189
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control
polar growth
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2001'
...
---
_id: '2982'
abstract:
- lang: eng
text: Polar auxin transport is crucial for the regulation of auxin action and required
for some light-regulated responses during plant development. We have found that
two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated
genes, and tir3, known for its reduced auxin transport - have similar defects
and define mutations in a single gene that we have renamed BIG. BIG is very similar
to the Drosophila gene Calossin/Pushover, a member of a gene family also present
in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary
in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling
experiments indicate that altered expression of multiple light-regulated genes
in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression
of an auxin biosynthetic gene, suggesting that normal auxin distribution is required
to maintain low-level expression of these genes in the dark. Double mutants of
tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent
growth of the inflorescence. Chemical inhibitors of auxin transport change the
intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants,
supporting the idea that BIG is required for normal auxin efflux.
acknowledgement: "We thank Kim Hanson and Melissa McCarthy for technical support,
and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating
and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were
supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning
this manuscript. This work was supported by grants from the Department of Energy
(DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by
grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes
of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to
K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate
Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow
of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article
were defrayed in part by payment of page charges. This article must therefore be
hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate
this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Pedro
full_name: Gil, Pedro
last_name: Gil
- first_name: Elizabeth
full_name: Dewey, Elizabeth
last_name: Dewey
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Yunde
full_name: Zhao, Yunde
last_name: Zhao
- first_name: Kimberley
full_name: Snowden, Kimberley
last_name: Snowden
- first_name: Jo
full_name: Putterill, Jo
last_name: Putterill
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Mark
full_name: Estelle, Mark
last_name: Estelle
- first_name: Joanne
full_name: Chory, Joanne
last_name: Chory
citation:
ama: 'Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for
polar auxin transport in Arabidopsis. Genes and Development. 2001;15(15):1985-1997.
doi:10.1101/gad.905201'
apa: 'Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory,
J. (2001). BIG: A calossin-like protein required for polar auxin transport in
Arabidopsis. Genes and Development. Cold Spring Harbor Laboratory Press.
https://doi.org/10.1101/gad.905201'
chicago: 'Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden,
Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like
Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development.
Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.905201.'
ieee: 'P. Gil et al., “BIG: A calossin-like protein required for polar auxin
transport in Arabidopsis,” Genes and Development, vol. 15, no. 15. Cold
Spring Harbor Laboratory Press, pp. 1985–1997, 2001.'
ista: 'Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle
M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport
in Arabidopsis. Genes and Development. 15(15), 1985–1997.'
mla: 'Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin
Transport in Arabidopsis.” Genes and Development, vol. 15, no. 15, Cold
Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:10.1101/gad.905201.'
short: P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme,
M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-16T11:59:47Z
day: '01'
doi: 10.1101/gad.905201
extern: '1'
external_id:
pmid:
- '11485992'
intvolume: ' 15'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/
month: '08'
oa: 1
oa_version: Published Version
page: 1985 - 1997
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3720'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'BIG: A calossin-like protein required for polar auxin transport in Arabidopsis'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '2983'
abstract:
- lang: eng
text: Polar transport of the phytohormone auxin mediates various processes in plant
growth and development, such as apical dominance, tropisms, vascular patterning
and axis formation. This view is based largely on the effects of polar auxin transport
inhibitors. These compounds disrupt auxin efflux from the cell but their mode
of action is unknown. It is thought that polar auxin flux is caused by the asymmetric
distribution of efflux carriers acting at the plasma membrane. The polar localization
of efflux carrier candidate PIN1 supports this model. Here we show that the seemingly
static localization of PIN1 results from rapid actin-dependent cycling between
the plasma membrane and endosomal compartments. Auxin transport inhibitors block
PIN1 cycling and inhibit trafficking of membrane proteins that are unrelated to
auxin transport. Our data suggest that PIN1 cycling is of central importance for
auxin transport and that auxin transport inhibitors affect efflux by generally
interfering with membrane-trafficking processes. In support of our conclusion,
the vesicle-trafficking inhibitor brefeldin A mimics physiological effects of
auxin transport inhibitors.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Niko
full_name: Geldner, Niko
last_name: Geldner
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: York
full_name: Stierhof, York
last_name: Stierhof
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. Auxin transport inhibitors
block PIN1 cycling and vesicle trafficking. Nature. 2001;413(6854):425-428.
doi:10.1038/35096571
apa: Geldner, N., Friml, J., Stierhof, Y., Jürgens, G., & Palme, K. (2001).
Auxin transport inhibitors block PIN1 cycling and vesicle trafficking. Nature.
Nature Publishing Group. https://doi.org/10.1038/35096571
chicago: Geldner, Niko, Jiří Friml, York Stierhof, Gerd Jürgens, and Klaus Palme.
“Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle Trafficking.” Nature.
Nature Publishing Group, 2001. https://doi.org/10.1038/35096571.
ieee: N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, and K. Palme, “Auxin transport
inhibitors block PIN1 cycling and vesicle trafficking,” Nature, vol. 413,
no. 6854. Nature Publishing Group, pp. 425–428, 2001.
ista: Geldner N, Friml J, Stierhof Y, Jürgens G, Palme K. 2001. Auxin transport
inhibitors block PIN1 cycling and vesicle trafficking. Nature. 413(6854), 425–428.
mla: Geldner, Niko, et al. “Auxin Transport Inhibitors Block PIN1 Cycling and Vesicle
Trafficking.” Nature, vol. 413, no. 6854, Nature Publishing Group, 2001,
pp. 425–28, doi:10.1038/35096571.
short: N. Geldner, J. Friml, Y. Stierhof, G. Jürgens, K. Palme, Nature 413 (2001)
425–428.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-09-27T00:00:00Z
date_updated: 2023-05-16T11:51:44Z
day: '27'
doi: 10.1038/35096571
extern: '1'
external_id:
pmid:
- '11574889'
intvolume: ' 413'
issue: '6854'
language:
- iso: eng
month: '09'
oa_version: None
page: 425 - 428
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '3719'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 413
year: '2001'
...
---
_id: '2984'
abstract:
- lang: eng
text: Auxins represent an important class of plant hormone that regulate plant development.
Plants use specialized carrier proteins to transport the auxin indole-3-acetic
acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport
has been assumed to represent the sole mode of long distance IAA movement. Localization
of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based
IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of
root protophloem cells, is proposed to promote the acropetal, post-phloem movement
of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant
root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1
localization to columella and lateral root cap tissues of the Arabidopsis root
apex reveals that the auxin permease regulates a second IAA transport pathway.
Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary
for root gravitropism by facilitating basipetal auxin transport to distal elongation
zone tissues.
acknowledgement: "We thank Ben Scheres and Marcus Grebe for critically reading the
manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis
Baker for valuable discussion. This work was funded by the BBSRC and European Commission
grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs
of this article were defrayed in part by payment of page charges. This article must
therefore be hereby marked “advertisement” in accordance with 18 USC section 1734
solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Alan
full_name: Marchant, Alan
last_name: Marchant
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
citation:
ama: Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1
suggests two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex. Genes and Development. 2001;15(20):2648-2653. doi:10.1101/gad.210501
apa: Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., &
Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally
distinct hormone transport pathways operate in the Arabidopsis root apex. Genes
and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.210501
chicago: Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg,
Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests
Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis
Root Apex.” Genes and Development. Cold Spring Harbor Laboratory Press,
2001. https://doi.org/10.1101/gad.210501.
ieee: R. Swarup et al., “Localization of the auxin permease AUX1 suggests
two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex,” Genes and Development, vol. 15, no. 20. Cold Spring Harbor
Laboratory Press, pp. 2648–2653, 2001.
ista: Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001.
Localization of the auxin permease AUX1 suggests two functionally distinct hormone
transport pathways operate in the Arabidopsis root apex. Genes and Development.
15(20), 2648–2653.
mla: Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two
Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root
Apex.” Genes and Development, vol. 15, no. 20, Cold Spring Harbor Laboratory
Press, 2001, pp. 2648–53, doi:10.1101/gad.210501.
short: R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett,
Genes and Development 15 (2001) 2648–2653.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-10-15T00:00:00Z
date_updated: 2023-05-16T11:37:53Z
day: '15'
doi: 10.1101/gad.210501
extern: '1'
external_id:
pmid:
- '11641271'
intvolume: ' 15'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC312818/
month: '10'
oa: 1
oa_version: Published Version
page: 2648 - 2653
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- Genes and Development
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3718'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of the auxin permease AUX1 suggests two functionally distinct
hormone transport pathways operate in the Arabidopsis root apex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...