---
_id: '3920'
abstract:
- lang: eng
  text: A particular Solid Injector needle, suitable for GC-MS analyses of small specimens,
    is described together with its application in a study on ants.
acknowledgement: "We thank Giancarlo Bucelli and Gloriano Moneti (Centro Interdipartimentale\r\ndi
  Spettrometria di Massa, Università di Firenze) for their help. Funding was\r\nprovided
  by the MURST “60%” and Italian CNR “40%” funds, as well as through\r\nthe research
  network “Social evolution” of the Universities of Aarhus, Firenze,\r\nKeele, Sheffield,
  Uppsala, Würzburg and the ETH of Zürich financed by the\r\nEuropean commission via
  the Training and Mobility of Researchers (TMR)\r\nprogramme. "
article_processing_charge: No
article_type: original
author:
- first_name: Stefano
  full_name: Turillazzi, Stefano
  last_name: Turillazzi
- first_name: Matthew
  full_name: Sledge, Matthew
  last_name: Sledge
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
citation:
  ama: Turillazzi S, Sledge M, Cremer S, Heinze J. A method for analysing small-size
    specimens in GC-MS. <i>Insect Social Life</i>. 2002;4:169-175.
  apa: Turillazzi, S., Sledge, M., Cremer, S., &#38; Heinze, J. (2002). A method for
    analysing small-size specimens in GC-MS. <i>Insect Social Life</i>. Elsevier.
  chicago: Turillazzi, Stefano, Matthew Sledge, Sylvia Cremer, and Jürgen Heinze.
    “A Method for Analysing Small-Size Specimens in GC-MS.” <i>Insect Social Life</i>.
    Elsevier, 2002.
  ieee: S. Turillazzi, M. Sledge, S. Cremer, and J. Heinze, “A method for analysing
    small-size specimens in GC-MS,” <i>Insect Social Life</i>, vol. 4. Elsevier, pp.
    169–175, 2002.
  ista: Turillazzi S, Sledge M, Cremer S, Heinze J. 2002. A method for analysing small-size
    specimens in GC-MS. Insect Social Life. 4, 169–175.
  mla: Turillazzi, Stefano, et al. “A Method for Analysing Small-Size Specimens in
    GC-MS.” <i>Insect Social Life</i>, vol. 4, Elsevier, 2002, pp. 169–75.
  short: S. Turillazzi, M. Sledge, S. Cremer, J. Heinze, Insect Social Life 4 (2002)
    169–175.
date_created: 2018-12-11T12:05:54Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-13T12:57:06Z
day: '01'
extern: '1'
intvolume: '         4'
language:
- iso: eng
month: '01'
oa_version: None
page: 169 - 175
publication: Insect Social Life
publication_status: published
publisher: Elsevier
publist_id: '2232'
quality_controlled: '1'
status: public
title: A method for analysing small-size specimens in GC-MS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '2002'
...
---
_id: '3924'
abstract:
- lang: eng
  text: 'Males of the ant Cardiocondyla show a dispersal dimorphism of a winged and
    wingless morph. The loss of flight has lead to morphological reductions in the
    wingless (ergatoid) males and also affected body size, eye size and pigmentation.
    As ergatoid males mate exclusively inside the maternal nest, they underlie increased
    male-male competition and therefore have also evolved additional changes in behaviour
    and physiology: in contrast to winged males, ergatoid males are highly aggressive
    towards each other and their spermatogenesis is prolonged compared to all other
    hymenopteran males. In addition to these two male morphs, we found males with
    an intermediate appearance. These &quot;intermorphic&quot; males provide a transitional
    stage between normal males in most investigated morphological and physiological
    parameters. As they are produced extremely rarely and only in colonies that switch
    between pure ergatoid to mixed male production, we argue that they likely represent
    a developmental mistake. Parallels between the determination of male morphs and
    female castes (queen-worker dimorphism and worker polymorphism) might help to
    understand how the large potential of phenotypic plasticity in both sexes of social
    insects is realised during development.'
acknowledgement: We would like to thank S. Karpeles for histological analysis of the
  winged males and S. Buchhauser for help with the photographs. This study was funded
  by the DFG (grant He1623/12–1).
article_processing_charge: No
article_type: original
author:
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Birgit
  full_name: Lautenschläger, Birgit
  last_name: Lautenschläger
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
citation:
  ama: Cremer S, Lautenschläger B, Heinze J. A transitional stage between the ergatoid
    and winged male morph in the ant Cardiocondyla obscurior. <i>Insectes Sociaux</i>.
    2002;49(3):221-228. doi:<a href="https://doi.org/10.1007/s00040-002-8305-z">10.1007/s00040-002-8305-z</a>
  apa: Cremer, S., Lautenschläger, B., &#38; Heinze, J. (2002). A transitional stage
    between the ergatoid and winged male morph in the ant Cardiocondyla obscurior.
    <i>Insectes Sociaux</i>. Springer. <a href="https://doi.org/10.1007/s00040-002-8305-z">https://doi.org/10.1007/s00040-002-8305-z</a>
  chicago: Cremer, Sylvia, Birgit Lautenschläger, and Jürgen Heinze. “A Transitional
    Stage between the Ergatoid and Winged Male Morph in the Ant Cardiocondyla Obscurior.”
    <i>Insectes Sociaux</i>. Springer, 2002. <a href="https://doi.org/10.1007/s00040-002-8305-z">https://doi.org/10.1007/s00040-002-8305-z</a>.
  ieee: S. Cremer, B. Lautenschläger, and J. Heinze, “A transitional stage between
    the ergatoid and winged male morph in the ant Cardiocondyla obscurior,” <i>Insectes
    Sociaux</i>, vol. 49, no. 3. Springer, pp. 221–228, 2002.
  ista: Cremer S, Lautenschläger B, Heinze J. 2002. A transitional stage between the
    ergatoid and winged male morph in the ant Cardiocondyla obscurior. Insectes Sociaux.
    49(3), 221–228.
  mla: Cremer, Sylvia, et al. “A Transitional Stage between the Ergatoid and Winged
    Male Morph in the Ant Cardiocondyla Obscurior.” <i>Insectes Sociaux</i>, vol.
    49, no. 3, Springer, 2002, pp. 221–28, doi:<a href="https://doi.org/10.1007/s00040-002-8305-z">10.1007/s00040-002-8305-z</a>.
  short: S. Cremer, B. Lautenschläger, J. Heinze, Insectes Sociaux 49 (2002) 221–228.
date_created: 2018-12-11T12:05:55Z
date_published: 2002-04-05T00:00:00Z
date_updated: 2023-06-13T11:44:08Z
day: '05'
doi: 10.1007/s00040-002-8305-z
extern: '1'
intvolume: '        49'
issue: '3'
language:
- iso: eng
month: '04'
oa_version: None
page: 221 - 228
publication: Insectes Sociaux
publication_identifier:
  issn:
  - 0020-1812
publication_status: published
publisher: Springer
publist_id: '2229'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A transitional stage between the ergatoid and winged male morph in the ant
  Cardiocondyla obscurior
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '2002'
...
---
_id: '3925'
abstract:
- lang: eng
  text: Males of the tropical ant Cardiocondyla obscurior are either wingless and
    aggressive or winged and docile, and both compete for access to virgin queens
    in the nest1, 2. Although the fighter males (ergatoids) attack and kill other
    ergatoids, they tolerate and even attempt to mate with their winged rivals. Here
    we show that the winged males avoid the aggression of wingless males by mimicking
    the chemical bouquet of virgin queens, but that their mating success is not reduced
    as a result. This example of female mimicry by vigorous males is surprising, as
    in other species it is typically used as a protective strategy by weaker males,
    and may explain the coexistence and equal mating success of two male morphs.
article_processing_charge: No
article_type: original
author:
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Matthew
  full_name: Sledge, Matthew
  last_name: Sledge
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
citation:
  ama: 'Cremer S, Sledge M, Heinze J. Chemical mimicry: Male ants disguised by the
    queen’s bouquet. <i>Nature</i>. 2002;419:897-897. doi:<a href="https://doi.org/10.1038/419897a">10.1038/419897a</a>'
  apa: 'Cremer, S., Sledge, M., &#38; Heinze, J. (2002). Chemical mimicry: Male ants
    disguised by the queen’s bouquet. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/419897a">https://doi.org/10.1038/419897a</a>'
  chicago: 'Cremer, Sylvia, Matthew Sledge, and Jürgen Heinze. “Chemical Mimicry:
    Male Ants Disguised by the Queen’s Bouquet.” <i>Nature</i>. Nature Publishing
    Group, 2002. <a href="https://doi.org/10.1038/419897a">https://doi.org/10.1038/419897a</a>.'
  ieee: 'S. Cremer, M. Sledge, and J. Heinze, “Chemical mimicry: Male ants disguised
    by the queen’s bouquet,” <i>Nature</i>, vol. 419. Nature Publishing Group, pp.
    897–897, 2002.'
  ista: 'Cremer S, Sledge M, Heinze J. 2002. Chemical mimicry: Male ants disguised
    by the queen’s bouquet. Nature. 419, 897–897.'
  mla: 'Cremer, Sylvia, et al. “Chemical Mimicry: Male Ants Disguised by the Queen’s
    Bouquet.” <i>Nature</i>, vol. 419, Nature Publishing Group, 2002, pp. 897–897,
    doi:<a href="https://doi.org/10.1038/419897a">10.1038/419897a</a>.'
  short: S. Cremer, M. Sledge, J. Heinze, Nature 419 (2002) 897–897.
date_created: 2018-12-11T12:05:55Z
date_published: 2002-10-31T00:00:00Z
date_updated: 2023-06-13T11:47:19Z
day: '31'
doi: 10.1038/419897a
extern: '1'
external_id:
  pmid:
  - '12410300'
intvolume: '       419'
language:
- iso: eng
month: '10'
oa_version: None
page: 897 - 897
pmid: 1
publication: Nature
publication_identifier:
  issn:
  - 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '2230'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Chemical mimicry: Male ants disguised by the queen''s bouquet'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 419
year: '2002'
...
---
_id: '3995'
abstract:
- lang: eng
  text: This article is a survey of research areas in which motion plays a pivotal
    role. The aim of the article is to review current approaches to modeling motion
    together with related data structures and algorithms, and to summarize the challenges
    that lie ahead in producing a more unified theory of motion representation that
    would be useful across several disciplines.
acknowledgement: "This article is based on the report of the Workshop on Algorithmic
  Issues in Modeling Motion, sponsored\r\nby an NSF grant CCR-00-83-033 and an Army
  Research Office grant DAAD 19-00-1-0478, held on August 6\r\nand 7, 2000 at Duke
  University, Durham, NC."
article_processing_charge: No
article_type: original
author:
- first_name: Pankaj
  full_name: Agarwal, Pankaj
  last_name: Agarwal
- first_name: Leonidas
  full_name: Guibas, Leonidas
  last_name: Guibas
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Jeff
  full_name: Erickson, Jeff
  last_name: Erickson
- first_name: Michael
  full_name: Isard, Michael
  last_name: Isard
- first_name: Sariel
  full_name: Har Peled, Sariel
  last_name: Har Peled
- first_name: John
  full_name: Hershberger, John
  last_name: Hershberger
- first_name: Christian
  full_name: Jensen, Christian
  last_name: Jensen
- first_name: Lydia
  full_name: Kavraki, Lydia
  last_name: Kavraki
- first_name: Patrice
  full_name: Koehl, Patrice
  last_name: Koehl
- first_name: Ming
  full_name: Lin, Ming
  last_name: Lin
- first_name: Dinesh
  full_name: Manocha, Dinesh
  last_name: Manocha
- first_name: Dimitris
  full_name: Metaxas, Dimitris
  last_name: Metaxas
- first_name: Brian
  full_name: Mirtich, Brian
  last_name: Mirtich
- first_name: David
  full_name: Mount, David
  last_name: Mount
- first_name: Sankara
  full_name: Muthukrishnan, Sankara
  last_name: Muthukrishnan
- first_name: Dinesh
  full_name: Pai, Dinesh
  last_name: Pai
- first_name: Elisha
  full_name: Sacks, Elisha
  last_name: Sacks
- first_name: Jack
  full_name: Snoeyink, Jack
  last_name: Snoeyink
- first_name: Subhash
  full_name: Suri, Subhash
  last_name: Suri
- first_name: Ouri
  full_name: Wolefson, Ouri
  last_name: Wolefson
citation:
  ama: Agarwal P, Guibas L, Edelsbrunner H, et al. Algorithmic issues in modeling
    motion. <i>ACM Computing Surveys</i>. 2002;34(4):550-572. doi:<a href="https://doi.org/10.1145/592642.592647">10.1145/592642.592647</a>
  apa: Agarwal, P., Guibas, L., Edelsbrunner, H., Erickson, J., Isard, M., Har Peled,
    S., … Wolefson, O. (2002). Algorithmic issues in modeling motion. <i>ACM Computing
    Surveys</i>. ACM. <a href="https://doi.org/10.1145/592642.592647">https://doi.org/10.1145/592642.592647</a>
  chicago: Agarwal, Pankaj, Leonidas Guibas, Herbert Edelsbrunner, Jeff Erickson,
    Michael Isard, Sariel Har Peled, John Hershberger, et al. “Algorithmic Issues
    in Modeling Motion.” <i>ACM Computing Surveys</i>. ACM, 2002. <a href="https://doi.org/10.1145/592642.592647">https://doi.org/10.1145/592642.592647</a>.
  ieee: P. Agarwal <i>et al.</i>, “Algorithmic issues in modeling motion,” <i>ACM
    Computing Surveys</i>, vol. 34, no. 4. ACM, pp. 550–572, 2002.
  ista: Agarwal P, Guibas L, Edelsbrunner H, Erickson J, Isard M, Har Peled S, Hershberger
    J, Jensen C, Kavraki L, Koehl P, Lin M, Manocha D, Metaxas D, Mirtich B, Mount
    D, Muthukrishnan S, Pai D, Sacks E, Snoeyink J, Suri S, Wolefson O. 2002. Algorithmic
    issues in modeling motion. ACM Computing Surveys. 34(4), 550–572.
  mla: Agarwal, Pankaj, et al. “Algorithmic Issues in Modeling Motion.” <i>ACM Computing
    Surveys</i>, vol. 34, no. 4, ACM, 2002, pp. 550–72, doi:<a href="https://doi.org/10.1145/592642.592647">10.1145/592642.592647</a>.
  short: P. Agarwal, L. Guibas, H. Edelsbrunner, J. Erickson, M. Isard, S. Har Peled,
    J. Hershberger, C. Jensen, L. Kavraki, P. Koehl, M. Lin, D. Manocha, D. Metaxas,
    B. Mirtich, D. Mount, S. Muthukrishnan, D. Pai, E. Sacks, J. Snoeyink, S. Suri,
    O. Wolefson, ACM Computing Surveys 34 (2002) 550–572.
date_created: 2018-12-11T12:06:20Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-13T11:34:25Z
day: '01'
doi: 10.1145/592642.592647
extern: '1'
intvolume: '        34'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 550 - 572
publication: ACM Computing Surveys
publication_identifier:
  issn:
  - 0360-0300
publication_status: published
publisher: ACM
publist_id: '2129'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithmic issues in modeling motion
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 34
year: '2002'
...
---
_id: '3996'
abstract:
- lang: eng
  text: We formalize a notion of topological simplification within the framework of
    a filtration, which is the history of a growing complex. We classify a topological
    change that happens during growth as either a feature or noise depending on its
    lifetime or persistence within the filtration. We give fast algorithms for computing
    persistence and experimental evidence for their speed and utility.
acknowledgement: "We thank Jeff Erickson and John Harer for helpful discussions during
  early stages of this\r\npaper. We also thank Daniel Huson for the zeolite dataset
  Z, Thomas LaBean for the DNA\r\ndataset D, and the Stanford Graphics Lab for the
  Buddha dataset S. To generate the bone\r\ndataset B, we sampled an iso-surface generated
  by Dominique Attali. The volume data\r\nTopological Persistence and Simplification
  533 was provided by Francoise Peyrin from CNRS CREATIS in Lyon and was issued from
  ¸ Synchrotron Radiation Microtomography from the ID19 beamline at ESRF in Grenoble.\r\nWe
  generated Fig. 17 using the Protein Explorer [6]."
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: David
  full_name: Letscher, David
  last_name: Letscher
- first_name: Afra
  full_name: Zomorodian, Afra
  last_name: Zomorodian
citation:
  ama: Edelsbrunner H, Letscher D, Zomorodian A. Topological persistence and simplification.
    <i>Discrete &#38; Computational Geometry</i>. 2002;28(4):511-533. doi:<a href="https://doi.org/10.1007/s00454-002-2885-2">10.1007/s00454-002-2885-2</a>
  apa: Edelsbrunner, H., Letscher, D., &#38; Zomorodian, A. (2002). Topological persistence
    and simplification. <i>Discrete &#38; Computational Geometry</i>. Springer. <a
    href="https://doi.org/10.1007/s00454-002-2885-2">https://doi.org/10.1007/s00454-002-2885-2</a>
  chicago: Edelsbrunner, Herbert, David Letscher, and Afra Zomorodian. “Topological
    Persistence and Simplification.” <i>Discrete &#38; Computational Geometry</i>.
    Springer, 2002. <a href="https://doi.org/10.1007/s00454-002-2885-2">https://doi.org/10.1007/s00454-002-2885-2</a>.
  ieee: H. Edelsbrunner, D. Letscher, and A. Zomorodian, “Topological persistence
    and simplification,” <i>Discrete &#38; Computational Geometry</i>, vol. 28, no.
    4. Springer, pp. 511–533, 2002.
  ista: Edelsbrunner H, Letscher D, Zomorodian A. 2002. Topological persistence and
    simplification. Discrete &#38; Computational Geometry. 28(4), 511–533.
  mla: Edelsbrunner, Herbert, et al. “Topological Persistence and Simplification.”
    <i>Discrete &#38; Computational Geometry</i>, vol. 28, no. 4, Springer, 2002,
    pp. 511–33, doi:<a href="https://doi.org/10.1007/s00454-002-2885-2">10.1007/s00454-002-2885-2</a>.
  short: H. Edelsbrunner, D. Letscher, A. Zomorodian, Discrete &#38; Computational
    Geometry 28 (2002) 511–533.
date_created: 2018-12-11T12:06:20Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-13T11:41:19Z
day: '01'
doi: 10.1007/s00454-002-2885-2
extern: '1'
intvolume: '        28'
issue: '4'
language:
- iso: eng
month: '12'
oa_version: None
page: 511 - 533
publication: Discrete & Computational Geometry
publication_identifier:
  issn:
  - 0179-5376
publication_status: published
publisher: Springer
publist_id: '2130'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Topological persistence and simplification
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 28
year: '2002'
...
---
_id: '3998'
abstract:
- lang: eng
  text: We present results on a two-step improvement of mesh quality in three-dimensional
    Delaunay triangulations. The first step refines the triangulation by inserting
    sinks and eliminates tetrahedra with large circumradius over shortest edge length
    ratio. The second step assigns weights to the vertices to eliminate slivers. Our
    experimental findings provide evidence for the practical effectiveness of sliver
    exudation.
acknowledgement: NSF under grants CCR-97-12088 and DMS 98-73945, NSF under grands
  EIA-9972879 and CCR-00-86013 and by ARO under grant DAAG55-98-1- 0177.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Damrong
  full_name: Guoy, Damrong
  last_name: Guoy
citation:
  ama: Edelsbrunner H, Guoy D. An experimental study of sliver exudation. <i>Engineering
    with Computers</i>. 2002;18(3):229-240. doi:<a href="https://doi.org/10.1007/s003660200020">10.1007/s003660200020</a>
  apa: Edelsbrunner, H., &#38; Guoy, D. (2002). An experimental study of sliver exudation.
    <i>Engineering with Computers</i>. Springer. <a href="https://doi.org/10.1007/s003660200020">https://doi.org/10.1007/s003660200020</a>
  chicago: Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver
    Exudation.” <i>Engineering with Computers</i>. Springer, 2002. <a href="https://doi.org/10.1007/s003660200020">https://doi.org/10.1007/s003660200020</a>.
  ieee: H. Edelsbrunner and D. Guoy, “An experimental study of sliver exudation,”
    <i>Engineering with Computers</i>, vol. 18, no. 3. Springer, pp. 229–240, 2002.
  ista: Edelsbrunner H, Guoy D. 2002. An experimental study of sliver exudation. Engineering
    with Computers. 18(3), 229–240.
  mla: Edelsbrunner, Herbert, and Damrong Guoy. “An Experimental Study of Sliver Exudation.”
    <i>Engineering with Computers</i>, vol. 18, no. 3, Springer, 2002, pp. 229–40,
    doi:<a href="https://doi.org/10.1007/s003660200020">10.1007/s003660200020</a>.
  short: H. Edelsbrunner, D. Guoy, Engineering with Computers 18 (2002) 229–240.
date_created: 2018-12-11T12:06:21Z
date_published: 2002-10-01T00:00:00Z
date_updated: 2023-06-13T11:14:44Z
day: '01'
doi: 10.1007/s003660200020
extern: '1'
intvolume: '        18'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 229 - 240
publication: Engineering with Computers
publication_identifier:
  issn:
  - 0177-0667
publication_status: published
publisher: Springer
publist_id: '2126'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An experimental study of sliver exudation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '2002'
...
---
_id: '4000'
abstract:
- lang: eng
  text: We present fast implementations of a hybrid algorithm for reporting box and
    cube intersections. Our algorithm initially takes a divide-and-conquer approach
    and switches to simpler algorithms for low numbers of boxes. We use our implementations
    as engines to solve problems about geometric primitives. We look at two such problems
    in the category of quality analysis of surface triangulations.
acknowledgement: Center for Simulation of Advanced Rockets funded by the U.S. Department
  of Energy under Subcontract B341494, NSF under grant CCR-96-19542 and ARO under
  grant DAAG55-98-1-0177.
article_processing_charge: No
article_type: original
author:
- first_name: Afra
  full_name: Zomorodian, Afra
  last_name: Zomorodian
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: Zomorodian A, Edelsbrunner H. Fast software for box intersections. <i>International
    Journal of Computational Geometry and Applications</i>. 2002;12(1-2):143-172.
    doi:<a href="https://doi.org/10.1142/S0218195902000785">10.1142/S0218195902000785</a>
  apa: Zomorodian, A., &#38; Edelsbrunner, H. (2002). Fast software for box intersections.
    <i>International Journal of Computational Geometry and Applications</i>. World
    Scientific Publishing. <a href="https://doi.org/10.1142/S0218195902000785">https://doi.org/10.1142/S0218195902000785</a>
  chicago: Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.”
    <i>International Journal of Computational Geometry and Applications</i>. World
    Scientific Publishing, 2002. <a href="https://doi.org/10.1142/S0218195902000785">https://doi.org/10.1142/S0218195902000785</a>.
  ieee: A. Zomorodian and H. Edelsbrunner, “Fast software for box intersections,”
    <i>International Journal of Computational Geometry and Applications</i>, vol.
    12, no. 1–2. World Scientific Publishing, pp. 143–172, 2002.
  ista: Zomorodian A, Edelsbrunner H. 2002. Fast software for box intersections. International
    Journal of Computational Geometry and Applications. 12(1–2), 143–172.
  mla: Zomorodian, Afra, and Herbert Edelsbrunner. “Fast Software for Box Intersections.”
    <i>International Journal of Computational Geometry and Applications</i>, vol.
    12, no. 1–2, World Scientific Publishing, 2002, pp. 143–72, doi:<a href="https://doi.org/10.1142/S0218195902000785">10.1142/S0218195902000785</a>.
  short: A. Zomorodian, H. Edelsbrunner, International Journal of Computational Geometry
    and Applications 12 (2002) 143–172.
date_created: 2018-12-11T12:06:22Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-13T11:20:09Z
day: '01'
doi: 10.1142/S0218195902000785
extern: '1'
intvolume: '        12'
issue: 1-2
language:
- iso: eng
month: '01'
oa_version: None
page: 143 - 172
publication: International Journal of Computational Geometry and Applications
publication_identifier:
  issn:
  - 0218-1959
publication_status: published
publisher: World Scientific Publishing
publist_id: '2128'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast software for box intersections
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '4003'
abstract:
- lang: eng
  text: The writhing number measures the global geometry of a closed space curve or
    knot. We show that this measure is related to the average winding number of its
    Gauss map. Using this relationship, we give an algorithm for computing the writhing
    number for a polygonal knot with n edges in time roughly proportional to n(1.6).
    We also implement a different, simple algorithm and provide experimental evidence
    for its practical efficiency.
acknowledgement: NSF under grants CCR-00-86013 and EIA-9972879, NSF under grant CCR-97-12088.
article_processing_charge: No
author:
- first_name: Pankaj
  full_name: Agarwal, Pankaj
  last_name: Agarwal
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Yusu
  full_name: Wang, Yusu
  last_name: Wang
citation:
  ama: 'Agarwal P, Edelsbrunner H, Wang Y. Computing the writhing number of a polygonal
    knot. In: <i>Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms</i>.
    SIAM; 2002:791-799.'
  apa: 'Agarwal, P., Edelsbrunner, H., &#38; Wang, Y. (2002). Computing the writhing
    number of a polygonal knot. In <i>Proceedings of the 13th annual ACM-SIAM symposium
    on Discrete algorithms</i> (pp. 791–799). San Francisco, CA, USA: SIAM.'
  chicago: Agarwal, Pankaj, Herbert Edelsbrunner, and Yusu Wang. “Computing the Writhing
    Number of a Polygonal Knot.” In <i>Proceedings of the 13th Annual ACM-SIAM Symposium
    on Discrete Algorithms</i>, 791–99. SIAM, 2002.
  ieee: P. Agarwal, H. Edelsbrunner, and Y. Wang, “Computing the writhing number of
    a polygonal knot,” in <i>Proceedings of the 13th annual ACM-SIAM symposium on
    Discrete algorithms</i>, San Francisco, CA, USA, 2002, pp. 791–799.
  ista: 'Agarwal P, Edelsbrunner H, Wang Y. 2002. Computing the writhing number of
    a polygonal knot. Proceedings of the 13th annual ACM-SIAM symposium on Discrete
    algorithms. SODA: Symposium on Discrete Algorithms, 791–799.'
  mla: Agarwal, Pankaj, et al. “Computing the Writhing Number of a Polygonal Knot.”
    <i>Proceedings of the 13th Annual ACM-SIAM Symposium on Discrete Algorithms</i>,
    SIAM, 2002, pp. 791–99.
  short: P. Agarwal, H. Edelsbrunner, Y. Wang, in:, Proceedings of the 13th Annual
    ACM-SIAM Symposium on Discrete Algorithms, SIAM, 2002, pp. 791–799.
conference:
  end_date: 2002-01-08
  location: San Francisco, CA, USA
  name: 'SODA: Symposium on Discrete Algorithms'
  start_date: 2002-01-06
date_created: 2018-12-11T12:06:23Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-07T13:50:04Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.5555/545381.545485
month: '01'
oa_version: None
page: 791 - 799
publication: Proceedings of the 13th annual ACM-SIAM symposium on Discrete algorithms
publication_identifier:
  isbn:
  - '9780898715132'
publication_status: published
publisher: SIAM
publist_id: '2125'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing the writhing number of a polygonal knot
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '4139'
abstract:
- lang: eng
  text: Pilot studies in England by Stopka and Macdonald revealed that allogrooming
    in the Old World wood mouse, Apodemus sylvaticus, is a commodity that males can
    trade for reproductive benefits with females. This study, which used a combination
    of field study and observations in experimental enclosures, revealed that specific
    experimental conditions such as group-size and sex-ratio manipulations have a
    significant effect on the pattern of allogrooming exchanged between individuals.
    Furthermore, females from the Czech population were more likely to associate with
    each other as revealed by the clustering of activity centers of females (i.e.,
    as opposed to almost exclusive ranges in English populations), and also by the
    higher intensity of allogrooming exchanged between females (i.e., virtually lacking
    in the previous experiment with English mice). Therefore, geographic variation
    and specific social conditions seem to be important driving factors for allogrooming
    behavior. Together with changes in overall grooming patterns, allogrooming between
    males and females remained invariably asymmetrical over all four experimental
    groups (i.e., two conditions for each sex) in that males provided more allogrooming
    to females than they received from them.
article_processing_charge: No
article_type: original
author:
- first_name: Jitka
  full_name: Polechova, Jitka
  id: 3BBFB084-F248-11E8-B48F-1D18A9856A87
  last_name: Polechova
  orcid: 0000-0003-0951-3112
- first_name: P.
  full_name: Stopka, P.
  last_name: Stopka
citation:
  ama: Polechova J, Stopka P. Geometry of social relationships in the Old World wood
    mouse, Apodemus sylvaticus. <i>Canadian Journal of Zoology</i>. 2002;80(8):1383-1388.
    doi:<a href="https://doi.org/10.1139/z02-128">10.1139/z02-128</a>
  apa: Polechova, J., &#38; Stopka, P. (2002). Geometry of social relationships in
    the Old World wood mouse, Apodemus sylvaticus. <i>Canadian Journal of Zoology</i>.
    NRC Research Press. <a href="https://doi.org/10.1139/z02-128">https://doi.org/10.1139/z02-128</a>
  chicago: Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the
    Old World Wood Mouse, Apodemus Sylvaticus.” <i>Canadian Journal of Zoology</i>.
    NRC Research Press, 2002. <a href="https://doi.org/10.1139/z02-128">https://doi.org/10.1139/z02-128</a>.
  ieee: J. Polechova and P. Stopka, “Geometry of social relationships in the Old World
    wood mouse, Apodemus sylvaticus,” <i>Canadian Journal of Zoology</i>, vol. 80,
    no. 8. NRC Research Press, pp. 1383–1388, 2002.
  ista: Polechova J, Stopka P. 2002. Geometry of social relationships in the Old World
    wood mouse, Apodemus sylvaticus. Canadian Journal of Zoology. 80(8), 1383–1388.
  mla: Polechova, Jitka, and P. Stopka. “Geometry of Social Relationships in the Old
    World Wood Mouse, Apodemus Sylvaticus.” <i>Canadian Journal of Zoology</i>, vol.
    80, no. 8, NRC Research Press, 2002, pp. 1383–88, doi:<a href="https://doi.org/10.1139/z02-128">10.1139/z02-128</a>.
  short: J. Polechova, P. Stopka, Canadian Journal of Zoology 80 (2002) 1383–1388.
date_created: 2018-12-11T12:07:10Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-07T12:53:35Z
day: '01'
doi: 10.1139/z02-128
extern: '1'
intvolume: '        80'
issue: '8'
language:
- iso: eng
month: '01'
oa_version: None
page: 1383 - 1388
publication: Canadian Journal of Zoology
publication_identifier:
  issn:
  - 0008-4301
publication_status: published
publisher: NRC Research Press
publist_id: '1981'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry of social relationships in the Old World wood mouse, Apodemus sylvaticus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 80
year: '2002'
...
---
_id: '4148'
abstract:
- lang: eng
  text: Members of the Wnt family have been implicated in a variety of developmental
    processes including axis formation, Patterning of the central nervous system and
    tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway
    similar to that involved in the establishment of planar cell polarity in Drosophila
    regulates convergent extension movements during zebrafish and Xenopus gastrulation.
    This finding provides a good starting point to dissect the complex cell biology
    and genetic regulation of vertebrate gastrulation movements.
acknowledgement: We would like to thank Steve Wilson for encouraging us to write this
  article and for critical comments on this manuscript, and Lila Solnica-Krezel for
  communicating results prior to publication. MT is supported by an MRC Career Development
  Award, MLC by a Wellcome Trust Fellowship and CPH by an Emmy–Noether–Fellowship
  from the DFG.
article_processing_charge: No
article_type: original
author:
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
- first_name: Miguel
  full_name: Concha, Miguel
  last_name: Concha
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Tada M, Concha M, Heisenberg C-PJ. Non-canonical Wnt signalling and regulation
    of gastrulation movements. <i>Seminars in Cell &#38; Developmental Biology</i>.
    2002;13(3):251-260. doi:<a href="https://doi.org/10.1016/S1084-9521(02)00052-6">10.1016/S1084-9521(02)00052-6</a>
  apa: Tada, M., Concha, M., &#38; Heisenberg, C.-P. J. (2002). Non-canonical Wnt
    signalling and regulation of gastrulation movements. <i>Seminars in Cell &#38;
    Developmental Biology</i>. Academic Press. <a href="https://doi.org/10.1016/S1084-9521(02)00052-6">https://doi.org/10.1016/S1084-9521(02)00052-6</a>
  chicago: Tada, Masazumi, Miguel Concha, and Carl-Philipp J Heisenberg. “Non-Canonical
    Wnt Signalling and Regulation of Gastrulation Movements.” <i>Seminars in Cell
    &#38; Developmental Biology</i>. Academic Press, 2002. <a href="https://doi.org/10.1016/S1084-9521(02)00052-6">https://doi.org/10.1016/S1084-9521(02)00052-6</a>.
  ieee: M. Tada, M. Concha, and C.-P. J. Heisenberg, “Non-canonical Wnt signalling
    and regulation of gastrulation movements,” <i>Seminars in Cell &#38; Developmental
    Biology</i>, vol. 13, no. 3. Academic Press, pp. 251–260, 2002.
  ista: Tada M, Concha M, Heisenberg C-PJ. 2002. Non-canonical Wnt signalling and
    regulation of gastrulation movements. Seminars in Cell &#38; Developmental Biology.
    13(3), 251–260.
  mla: Tada, Masazumi, et al. “Non-Canonical Wnt Signalling and Regulation of Gastrulation
    Movements.” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 13, no.
    3, Academic Press, 2002, pp. 251–60, doi:<a href="https://doi.org/10.1016/S1084-9521(02)00052-6">10.1016/S1084-9521(02)00052-6</a>.
  short: M. Tada, M. Concha, C.-P.J. Heisenberg, Seminars in Cell &#38; Developmental
    Biology 13 (2002) 251–260.
date_created: 2018-12-11T12:07:13Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-06-07T09:50:14Z
day: '01'
doi: 10.1016/S1084-9521(02)00052-6
extern: '1'
external_id:
  pmid:
  - '12137734'
intvolume: '        13'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 251 - 260
pmid: 1
publication: Seminars in Cell & Developmental Biology
publication_identifier:
  issn:
  - 1084-9521
publication_status: published
publisher: Academic Press
publist_id: '1973'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-canonical Wnt signalling and regulation of gastrulation movements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2002'
...
---
_id: '4194'
abstract:
- lang: eng
  text: Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic
    gene expression when transplanted to more posterior regions. Here, we identify
    a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells
    and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent
    manner. Moreover, abrogation of Tlc function compromises telencephalic development.
    We also identify Wnt8b as a locally acting modulator of regional fate in the anterior
    neural plate and a likely target for antagonism by Tic. Finally, we show that
    tlc expression is regulated by signals that establish early antero-posterior and
    dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism
    of Wnt activity within the anterior ectoderm is required to establish the telencephalon.
acknowledgement: We thank many of our colleagues, especially Randy Moon, for providing  reagents  used
  in this study. This study was  supported by the Wellcome Trust, MRC, and BBSRC to
  S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow.
article_processing_charge: No
article_type: original
author:
- first_name: Corinne
  full_name: Houart, Corinne
  last_name: Houart
- first_name: Luca
  full_name: Caneparo, Luca
  last_name: Caneparo
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: K Anukampa
  full_name: Barth, K Anukampa
  last_name: Barth
- first_name: Masaya
  full_name: Take Uchi, Masaya
  last_name: Take Uchi
- first_name: Stephen
  full_name: Wilson, Stephen
  last_name: Wilson
citation:
  ama: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment
    of the telencephalon during gastrulation by local antagonism of Wnt signaling.
    <i>Neuron</i>. 2002;35(2):255-265. doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a>
  apa: Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M.,
    &#38; Wilson, S. (2002). Establishment of the telencephalon during gastrulation
    by local antagonism of Wnt signaling. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a>
  chicago: Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth,
    Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during
    Gastrulation by Local Antagonism of Wnt Signaling.” <i>Neuron</i>. Elsevier, 2002.
    <a href="https://doi.org/10.1016/S0896-6273(02)00751-1">https://doi.org/10.1016/S0896-6273(02)00751-1</a>.
  ieee: C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and
    S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism
    of Wnt signaling,” <i>Neuron</i>, vol. 35, no. 2. Elsevier, pp. 255–265, 2002.
  ista: Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002.
    Establishment of the telencephalon during gastrulation by local antagonism of
    Wnt signaling. Neuron. 35(2), 255–265.
  mla: Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation
    by Local Antagonism of Wnt Signaling.” <i>Neuron</i>, vol. 35, no. 2, Elsevier,
    2002, pp. 255–65, doi:<a href="https://doi.org/10.1016/S0896-6273(02)00751-1">10.1016/S0896-6273(02)00751-1</a>.
  short: C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S.
    Wilson, Neuron 35 (2002) 255–265.
date_created: 2018-12-11T12:07:30Z
date_published: 2002-07-18T00:00:00Z
date_updated: 2023-06-07T09:43:19Z
day: '18'
doi: 10.1016/S0896-6273(02)00751-1
extern: '1'
external_id:
  pmid:
  - '12160744'
intvolume: '        35'
issue: '2'
language:
- iso: eng
month: '07'
oa_version: None
page: 255 - 265
pmid: 1
publication: Neuron
publication_identifier:
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '1925'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Establishment of the telencephalon during gastrulation by local antagonism
  of Wnt signaling
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 35
year: '2002'
...
---
_id: '4196'
abstract:
- lang: eng
  text: During vertebrate gastrulation, large cellular rearrangements lead to the
    formation of the three germ layers, ectoderm, mesoderm and endoderm. Zebrafish
    offer many genetic and experimental advantages for studying vertebrate gastrulation
    movements. For instance, several mutants, including silberblick, knypek and trilobite,
    exhibit defects in morphogenesis during gastrulation. The identification of the
    genes mutated in these lines together with the analysis of the mutant phenotypes
    has provided new insights into the molecular and cellular mechanisms that underlie
    vertebrate gastrulation movements.
acknowledgement: We would like to thank Miguel Concha, Will Norton, Tim Geach, Suzanne
  Eaton, Kimbo Kotovic, Jenny Geiger and Steve Wilson for critical comments on this
  manuscript, and Lila Solnica-Krezel for providing results prior to publication.
  C.-P.H. is supported by an Emmy-Noether-Fellowship from the DFG and M.T. by an MRC
  Career Development Award.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
citation:
  ama: 'Heisenberg C-PJ, Tada M. Zebrafish gastrulation movements: bridging cell and
    developmental biology. <i>Seminars in Cell &#38; Developmental Biology</i>. 2002;13(6):471-479.
    doi:<a href="https://doi.org/10.1016/S1084952102001003">10.1016/S1084952102001003</a>'
  apa: 'Heisenberg, C.-P. J., &#38; Tada, M. (2002). Zebrafish gastrulation movements:
    bridging cell and developmental biology. <i>Seminars in Cell &#38; Developmental
    Biology</i>. Academic Press. <a href="https://doi.org/10.1016/S1084952102001003">https://doi.org/10.1016/S1084952102001003</a>'
  chicago: 'Heisenberg, Carl-Philipp J, and Masazumi Tada. “Zebrafish Gastrulation
    Movements: Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38;
    Developmental Biology</i>. Academic Press, 2002. <a href="https://doi.org/10.1016/S1084952102001003">https://doi.org/10.1016/S1084952102001003</a>.'
  ieee: 'C.-P. J. Heisenberg and M. Tada, “Zebrafish gastrulation movements: bridging
    cell and developmental biology,” <i>Seminars in Cell &#38; Developmental Biology</i>,
    vol. 13, no. 6. Academic Press, pp. 471–479, 2002.'
  ista: 'Heisenberg C-PJ, Tada M. 2002. Zebrafish gastrulation movements: bridging
    cell and developmental biology. Seminars in Cell &#38; Developmental Biology.
    13(6), 471–479.'
  mla: 'Heisenberg, Carl-Philipp J., and Masazumi Tada. “Zebrafish Gastrulation Movements:
    Bridging Cell and Developmental Biology.” <i>Seminars in Cell &#38; Developmental
    Biology</i>, vol. 13, no. 6, Academic Press, 2002, pp. 471–79, doi:<a href="https://doi.org/10.1016/S1084952102001003">10.1016/S1084952102001003</a>.'
  short: C.-P.J. Heisenberg, M. Tada, Seminars in Cell &#38; Developmental Biology
    13 (2002) 471–479.
date_created: 2018-12-11T12:07:31Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-07T09:28:48Z
day: '01'
doi: 10.1016/S1084952102001003
extern: '1'
external_id:
  pmid:
  - '12468250'
intvolume: '        13'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 471 - 479
pmid: 1
publication: Seminars in Cell & Developmental Biology
publication_identifier:
  issn:
  - 1084-9521
publication_status: published
publisher: Academic Press
publist_id: '1920'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Zebrafish gastrulation movements: bridging cell and developmental biology'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '2002'
...
---
_id: '4199'
abstract:
- lang: eng
  text: Recent studies on vertebrate homologues of the van gogh/strabismus (vang/stbm)
    gene, a key player in planar cell polarity signalling in Drosophila, show that
    vang/stbm is involved in patterning and morphogenesis during vertebrate gastrulation
    where it modulates two distinct Wnt signals.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Masazumi
  full_name: Tada, Masazumi
  last_name: Tada
citation:
  ama: 'Heisenberg C-PJ, Tada M. Wnt signalling: A moving picture emerges from van
    gogh. <i>Current Biology</i>. 2002;12(4):R126-R128. doi:<a href="https://doi.org/10.1016/S0960-9822(02)00704-2">10.1016/S0960-9822(02)00704-2</a>'
  apa: 'Heisenberg, C.-P. J., &#38; Tada, M. (2002). Wnt signalling: A moving picture
    emerges from van gogh. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/S0960-9822(02)00704-2">https://doi.org/10.1016/S0960-9822(02)00704-2</a>'
  chicago: 'Heisenberg, Carl-Philipp J, and Masazumi Tada. “Wnt Signalling: A Moving
    Picture Emerges from van Gogh.” <i>Current Biology</i>. Cell Press, 2002. <a href="https://doi.org/10.1016/S0960-9822(02)00704-2">https://doi.org/10.1016/S0960-9822(02)00704-2</a>.'
  ieee: 'C.-P. J. Heisenberg and M. Tada, “Wnt signalling: A moving picture emerges
    from van gogh,” <i>Current Biology</i>, vol. 12, no. 4. Cell Press, pp. R126–R128,
    2002.'
  ista: 'Heisenberg C-PJ, Tada M. 2002. Wnt signalling: A moving picture emerges from
    van gogh. Current Biology. 12(4), R126–R128.'
  mla: 'Heisenberg, Carl-Philipp J., and Masazumi Tada. “Wnt Signalling: A Moving
    Picture Emerges from van Gogh.” <i>Current Biology</i>, vol. 12, no. 4, Cell Press,
    2002, pp. R126–28, doi:<a href="https://doi.org/10.1016/S0960-9822(02)00704-2">10.1016/S0960-9822(02)00704-2</a>.'
  short: C.-P.J. Heisenberg, M. Tada, Current Biology 12 (2002) R126–R128.
date_created: 2018-12-11T12:07:32Z
date_published: 2002-02-19T00:00:00Z
date_updated: 2023-06-07T08:54:35Z
day: '19'
doi: 10.1016/S0960-9822(02)00704-2
extern: '1'
external_id:
  pmid:
  - '11864583'
intvolume: '        12'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: R126 - R128
pmid: 1
publication: Current Biology
publication_identifier:
  issn:
  - 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1919'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Wnt signalling: A moving picture emerges from van gogh'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '4207'
abstract:
- lang: eng
  text: Vertebrate homologues of the Strabismus/van Gogh (stbm/vang) gene have been
    implicated in patterning and morphogenesis during gastrulation. Recent work shows
    that stbm/vang is mutated in zebrafish trilobite mutants and that stbm/vang is
    required for morphogenesis but not patterning during zebrafish gastrulation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Heisenberg C-PJ. Wnt signalling: Refocusing on Strabismus. <i>Current Biology</i>.
    2002;12(19):R657-R659. doi:<a href="https://doi.org/10.1016/S0960-9822(02)01160-0">10.1016/S0960-9822(02)01160-0</a>'
  apa: 'Heisenberg, C.-P. J. (2002). Wnt signalling: Refocusing on Strabismus. <i>Current
    Biology</i>. Cell Press. <a href="https://doi.org/10.1016/S0960-9822(02)01160-0">https://doi.org/10.1016/S0960-9822(02)01160-0</a>'
  chicago: 'Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.”
    <i>Current Biology</i>. Cell Press, 2002. <a href="https://doi.org/10.1016/S0960-9822(02)01160-0">https://doi.org/10.1016/S0960-9822(02)01160-0</a>.'
  ieee: 'C.-P. J. Heisenberg, “Wnt signalling: Refocusing on Strabismus,” <i>Current
    Biology</i>, vol. 12, no. 19. Cell Press, pp. R657–R659, 2002.'
  ista: 'Heisenberg C-PJ. 2002. Wnt signalling: Refocusing on Strabismus. Current
    Biology. 12(19), R657–R659.'
  mla: 'Heisenberg, Carl-Philipp J. “Wnt Signalling: Refocusing on Strabismus.” <i>Current
    Biology</i>, vol. 12, no. 19, Cell Press, 2002, pp. R657–59, doi:<a href="https://doi.org/10.1016/S0960-9822(02)01160-0">10.1016/S0960-9822(02)01160-0</a>.'
  short: C.-P.J. Heisenberg, Current Biology 12 (2002) R657–R659.
date_created: 2018-12-11T12:07:35Z
date_published: 2002-10-01T00:00:00Z
date_updated: 2023-06-06T15:09:53Z
day: '01'
doi: 10.1016/S0960-9822(02)01160-0
extern: '1'
external_id:
  pmid:
  - '12361585'
intvolume: '        12'
issue: '19'
language:
- iso: eng
month: '10'
oa_version: None
page: R657 - R659
pmid: 1
publication: Current Biology
publication_identifier:
  issn:
  - 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1912'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Wnt signalling: Refocusing on Strabismus'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '4209'
abstract:
- lang: eng
  text: We have identified widerborst (wdb), a B' regulatory subunit of PP2A, as a
    conserved component of planar cell polarization mechanisms in both Drosophila
    and in zebrafish. In Drosophila, wdb acts at two steps during planar polarization
    of wing epithelial cells. It is required to organize tissue polarity proteins
    into proximal and distal cortical domains, thus determining wing hair orientation.
    It is also needed to generate the polarized membrane outgrowth that becomes the
    wing hair. Widerborst activates the catalytic subunit of PP2A and localizes to
    the distal side of a planar microtubule web that lies at the level of apical cell
    junctions. This suggests that polarized PP2A activation along the planar microtubule
    web is important for planar polarization. In zebrafish, two wdb homologs are required
    for convergent extension during gastrulation, supporting the conjecture that Drosophila
    planar cell polarization and vertebrate gastrulation movements are regulated by
    similar mechanisms.
acknowledgement: We gratefully acknowledge Bianca Habermann for assistance with bioinformatics,
  Jens Rietdorf and Arshad Desai for help with deconvolution, and Tadashi Uemura and
  Rick Fehon for providing antibodies. Arshad Desai, Christian Dahmann, Tony Hyman
  and Elly Tanaka provided helpful comments on the manuscript. Part of this work was
  performed at the EMBL in Heidelberg.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
  full_name: Hannus, Michael
  last_name: Hannus
- first_name: Fabian
  full_name: Feiguin, Fabian
  last_name: Feiguin
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Suzanne
  full_name: Eaton, Suzanne
  last_name: Eaton
citation:
  ama: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. Planar cell polarization requires
    Widerborst, a B′ regulatory subunit of protein phosphatase 2A. <i>Development</i>.
    2002;129(14):3493-3503. doi:<a href="https://doi.org/10.1242/dev.129.14.3493">10.1242/dev.129.14.3493</a>
  apa: Hannus, M., Feiguin, F., Heisenberg, C.-P. J., &#38; Eaton, S. (2002). Planar
    cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase
    2A. <i>Development</i>. Company of Biologists. <a href="https://doi.org/10.1242/dev.129.14.3493">https://doi.org/10.1242/dev.129.14.3493</a>
  chicago: Hannus, Michael, Fabian Feiguin, Carl-Philipp J Heisenberg, and Suzanne
    Eaton. “Planar Cell Polarization Requires Widerborst, a B′ Regulatory Subunit
    of Protein Phosphatase 2A.” <i>Development</i>. Company of Biologists, 2002. <a
    href="https://doi.org/10.1242/dev.129.14.3493">https://doi.org/10.1242/dev.129.14.3493</a>.
  ieee: M. Hannus, F. Feiguin, C.-P. J. Heisenberg, and S. Eaton, “Planar cell polarization
    requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A,” <i>Development</i>,
    vol. 129, no. 14. Company of Biologists, pp. 3493–3503, 2002.
  ista: Hannus M, Feiguin F, Heisenberg C-PJ, Eaton S. 2002. Planar cell polarization
    requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development.
    129(14), 3493–3503.
  mla: Hannus, Michael, et al. “Planar Cell Polarization Requires Widerborst, a B′
    Regulatory Subunit of Protein Phosphatase 2A.” <i>Development</i>, vol. 129, no.
    14, Company of Biologists, 2002, pp. 3493–503, doi:<a href="https://doi.org/10.1242/dev.129.14.3493">10.1242/dev.129.14.3493</a>.
  short: M. Hannus, F. Feiguin, C.-P.J. Heisenberg, S. Eaton, Development 129 (2002)
    3493–3503.
date_created: 2018-12-11T12:07:36Z
date_published: 2002-07-15T00:00:00Z
date_updated: 2023-06-06T14:07:49Z
day: '15'
doi: 10.1242/dev.129.14.3493
extern: '1'
external_id:
  pmid:
  - '12091318'
intvolume: '       129'
issue: '14'
language:
- iso: eng
month: '07'
oa_version: None
page: 3493 - 3503
pmid: 1
publication: Development
publication_identifier:
  issn:
  - 0950-1991
publication_status: published
publisher: Company of Biologists
publist_id: '1909'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein
  phosphatase 2A
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 129
year: '2002'
...
---
_id: '4258'
abstract:
- lang: eng
  text: We studied the effect of multilocus balancing selection on neutral nucleotide
    variability at linked sites by simulating a model where diallelic polymorphisms
    are maintained at an arbitrary number of selected loci by means of symmetric overdominance.
    Different combinations of alleles define different genetic backgrounds that subdivide
    the population and strongly affect variability. Several multilocus fitness regimes
    with different degrees of epistasis and gametic disequilibrium are allowed. Analytical
    results based on a multilocus extension of the structured coalescent predict that
    the expected linked neutral diversity increases exponentially with the number
    of selected loci and can become extremely large. Our simulation results show that
    although variability increases with the number of genetic backgrounds that are
    maintained in the population, it is reduced by random fluctuations in the frequencies
    of those backgrounds and does not reach high levels even in very large populations.
    We also show that previous results on balancing selection in single-locus systems
    do not extend to the multilocus scenario in a straightforward way. Different patterns
    of linkage disequilibrium and of the frequency spectrum of neutral mutations are
    expected under different degrees of epistasis. Interestingly, the power to detect
    balancing selection using deviations from a neutral distribution of allele frequencies
    seems to be diminished under the fitness regime that leads to the largest increase
    of variability over the neutral case. This and other results are discussed in
    the light of data from the Mhc.
acknowledgement: We thank P. Andolfatto, P. Awadalla, B. Charlesworth, D. Charles-
  Guillaudeux, T., M. Janer, G. K. S. Wong, T. Spies and D. E. Geraghty, F. Depaulis,
  S. Otto, J. Rozas, and three anonymous reviewers for valuable discussion and criticism.
  A.N. is grateful to F. Depaulis, whose comments were particularly helpful (and extremely
  funny), and to D. Charlesworth, whose ideas made this work readable. This work was
  supported by Biotechnology and Biological Sciences Research Council/Engineering
  and Physical Sciences Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Arcadio
  full_name: Navarro, Arcadio
  last_name: Navarro
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Navarro A, Barton NH. The effects of multilocus balancing selection on neutral
    variability. <i>Genetics</i>. 2002;161(2):849-863. doi:<a href="https://doi.org/10.1093/genetics/161.2.849">10.1093/genetics/161.2.849</a>
  apa: Navarro, A., &#38; Barton, N. H. (2002). The effects of multilocus balancing
    selection on neutral variability. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1093/genetics/161.2.849">https://doi.org/10.1093/genetics/161.2.849</a>
  chicago: Navarro, Arcadio, and Nicholas H Barton. “The Effects of Multilocus Balancing
    Selection on Neutral Variability.” <i>Genetics</i>. Genetics Society of America,
    2002. <a href="https://doi.org/10.1093/genetics/161.2.849">https://doi.org/10.1093/genetics/161.2.849</a>.
  ieee: A. Navarro and N. H. Barton, “The effects of multilocus balancing selection
    on neutral variability,” <i>Genetics</i>, vol. 161, no. 2. Genetics Society of
    America, pp. 849–863, 2002.
  ista: Navarro A, Barton NH. 2002. The effects of multilocus balancing selection
    on neutral variability. Genetics. 161(2), 849–863.
  mla: Navarro, Arcadio, and Nicholas H. Barton. “The Effects of Multilocus Balancing
    Selection on Neutral Variability.” <i>Genetics</i>, vol. 161, no. 2, Genetics
    Society of America, 2002, pp. 849–63, doi:<a href="https://doi.org/10.1093/genetics/161.2.849">10.1093/genetics/161.2.849</a>.
  short: A. Navarro, N.H. Barton, Genetics 161 (2002) 849–863.
date_created: 2018-12-11T12:07:53Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-06-06T12:02:32Z
day: '01'
doi: 10.1093/genetics/161.2.849
extern: '1'
external_id:
  pmid:
  - '12072479'
intvolume: '       161'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462137/
month: '06'
oa: 1
oa_version: Published Version
page: 849 - 863
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1835'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effects of multilocus balancing selection on neutral variability
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...
---
_id: '4259'
abstract:
- lang: eng
  text: 'We extend current multilocus models to describe the effects of migration,
    recombination, selection, and nonrandom mating on sets of genes in diploids with
    varied modes of inheritance, allowing us to consider the patterns of nuclear and
    cytonuclear associations (disequilibria) under various models of migration. We
    show the relationship between the multilocus notation recently presented by Kirkpatrick,
    Johnson, and Barton (developed from previous work by Barton and Turelli) and the
    cytonuclear parameterization of Asmussen, Arnold, and Avise and extend this notation
    to describe associations between cytoplasmic elements and multiple nuclear genes.
    Under models with sexual symmetry, both nuclear-nuclear and cytonuclear disequilibria
    are equivalent. They differ, however, in cases involving some type of sexual asymmetry,
    which is then reflected in the asymmetric inheritance of cytoplasmic markers.
    An example given is the case of different migration rates in males and females;
    simulations using 2, 3, 4, or 5 unlinked autosomal markers with a maternally inherited
    cytoplasmic marker illustrate how nuclear-nuclear and cytonuclear associations
    can be used to separately estimate female and male migration rates. The general
    framework developed here allows us to investigate conditions where associations
    between loci with different modes of inheritance are not equivalent and to use
    this nonequivalence to test for deviations from simple models of admixture. '
acknowledgement: The authors thank Toby Johnson for his helpful comments on this manuscript.
  This work was supported by a National Science Foundation NATO postdoctoral fellowship
  and National Science Foundation grants DEB-9813335 and DEB-0108242 to M.E.O.; N.H.B.
  gratefully acknowledges the support of the Darwin Trust of Edinburgh and the National
  Environmental Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Maria
  full_name: Orive, Maria
  last_name: Orive
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Orive M, Barton NH. Associations between cytoplasmic and nuclear loci in hybridizing
    populations. <i>Genetics</i>. 2002;162(3):1469-1485. doi:<a href="https://doi.org/10.1093/genetics/162.3.1469">10.1093/genetics/162.3.1469</a>
  apa: Orive, M., &#38; Barton, N. H. (2002). Associations between cytoplasmic and
    nuclear loci in hybridizing populations. <i>Genetics</i>. Genetics Society of
    America. <a href="https://doi.org/10.1093/genetics/162.3.1469">https://doi.org/10.1093/genetics/162.3.1469</a>
  chicago: Orive, Maria, and Nicholas H Barton. “Associations between Cytoplasmic
    and Nuclear Loci in Hybridizing Populations.” <i>Genetics</i>. Genetics Society
    of America, 2002. <a href="https://doi.org/10.1093/genetics/162.3.1469">https://doi.org/10.1093/genetics/162.3.1469</a>.
  ieee: M. Orive and N. H. Barton, “Associations between cytoplasmic and nuclear loci
    in hybridizing populations,” <i>Genetics</i>, vol. 162, no. 3. Genetics Society
    of America, pp. 1469–1485, 2002.
  ista: Orive M, Barton NH. 2002. Associations between cytoplasmic and nuclear loci
    in hybridizing populations. Genetics. 162(3), 1469–1485.
  mla: Orive, Maria, and Nicholas H. Barton. “Associations between Cytoplasmic and
    Nuclear Loci in Hybridizing Populations.” <i>Genetics</i>, vol. 162, no. 3, Genetics
    Society of America, 2002, pp. 1469–85, doi:<a href="https://doi.org/10.1093/genetics/162.3.1469">10.1093/genetics/162.3.1469</a>.
  short: M. Orive, N.H. Barton, Genetics 162 (2002) 1469–1485.
date_created: 2018-12-11T12:07:54Z
date_published: 2002-11-01T00:00:00Z
date_updated: 2023-06-06T12:19:54Z
day: '01'
doi: 10.1093/genetics/162.3.1469
extern: '1'
external_id:
  pmid:
  - '12454089'
intvolume: '       162'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462324/
month: '11'
oa: 1
oa_version: Published Version
page: 1469 - 1485
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1836'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Associations between cytoplasmic and nuclear loci in hybridizing populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 162
year: '2002'
...
---
_id: '4260'
abstract:
- lang: eng
  text: 'We calculate the fixation probability of a beneficial allele that arises
    as the result of a unique mutation in an asexual population that is subject to
    recurrent deleterious mutation at rate U. Our analysis is an extension of previous
    works, which make a biologically restrictive assumption that selection against
    deleterious alleles is stronger than that on the beneficial allele of interest.
    We show that when selection against deleterious alleles is weak, beneficial alleles
    that confer a selective advantage that is small relative to U have greatly reduced
    probabilities of fixation. We discuss the consequences of this effect for the
    distribution of effects of alleles fixed during adaptation. We show that a selective
    sweep will increase the fixation probabilities of other beneficial mutations arising
    during some short interval afterward. We use the calculated fixation probabilities
    to estimate the expected rate of fitness improvement in an asexual population
    when beneficial alleles arise continually at some low rate proportional to U.
    We estimate the rate of mutation that is optimal in the sense that it maximizes
    this rate of fitness improvement. Again, this analysis relaxes the assumption
    made previously that selection against deleterious alleles is stronger than on
    beneficial alleles. '
acknowledgement: "We thank Brian Charlesworth, Arcadi Navarro, Allen Orr, Sally Otto,
  Mario Pineda-Krch, Rosie Redfield, Olivier Tenaillon, and two anonymous reviewers
  for discussions and/or helpful comments on the\r\nmanuscript. T.J. is supported
  by Wellcome Trust International Prize Travelling Research Fellowship no. 061530.
  N.B. is supported by the Biotechnology and Biological Sciences Research Council
  and by the Natural Environment Research Council."
article_processing_charge: No
article_type: original
author:
- first_name: Toby
  full_name: Johnson, Toby
  last_name: Johnson
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Johnson T, Barton NH. The effect of deleterious alleles on adaptation in asexual
    populations. <i>Genetics</i>. 2002;162(1):395-411. doi:<a href="https://doi.org/10.1093/genetics/162.1.395">10.1093/genetics/162.1.395</a>
  apa: Johnson, T., &#38; Barton, N. H. (2002). The effect of deleterious alleles
    on adaptation in asexual populations. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1093/genetics/162.1.395">https://doi.org/10.1093/genetics/162.1.395</a>
  chicago: Johnson, Toby, and Nicholas H Barton. “The Effect of Deleterious Alleles
    on Adaptation in Asexual Populations.” <i>Genetics</i>. Genetics Society of America,
    2002. <a href="https://doi.org/10.1093/genetics/162.1.395">https://doi.org/10.1093/genetics/162.1.395</a>.
  ieee: T. Johnson and N. H. Barton, “The effect of deleterious alleles on adaptation
    in asexual populations,” <i>Genetics</i>, vol. 162, no. 1. Genetics Society of
    America, pp. 395–411, 2002.
  ista: Johnson T, Barton NH. 2002. The effect of deleterious alleles on adaptation
    in asexual populations. Genetics. 162(1), 395–411.
  mla: Johnson, Toby, and Nicholas H. Barton. “The Effect of Deleterious Alleles on
    Adaptation in Asexual Populations.” <i>Genetics</i>, vol. 162, no. 1, Genetics
    Society of America, 2002, pp. 395–411, doi:<a href="https://doi.org/10.1093/genetics/162.1.395">10.1093/genetics/162.1.395</a>.
  short: T. Johnson, N.H. Barton, Genetics 162 (2002) 395–411.
date_created: 2018-12-11T12:07:54Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-06-06T11:45:48Z
day: '01'
doi: 10.1093/genetics/162.1.395
extern: '1'
external_id:
  pmid:
  - '12242249'
intvolume: '       162'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462245/
month: '09'
oa: 1
oa_version: None
page: 395 - 411
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1833'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effect of deleterious alleles on adaptation in asexual populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 162
year: '2002'
...
---
_id: '4261'
abstract:
- lang: eng
  text: Until recently, it was impracticable to identify the genes that are responsible
    for variation in continuous traits, or to directly observe the effects of their
    different alleles. Now, the abundance of genetic markers has made it possible
    to identify quantitative trait loci (QTL) — the regions of a chromosome or, ideally,
    individual sequence variants that are responsible for trait variation. What kind
    of QTL do we expect to find and what can our observations of QTL tell us about
    how organisms evolve? The key to understanding the evolutionary significance of
    QTL is to understand the nature of inherited variation, not in the immediate mechanistic
    sense of how genes influence phenotype, but, rather, to know what evolutionary
    forces maintain genetic variability.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Peter
  full_name: Keightley, Peter
  last_name: Keightley
citation:
  ama: Barton NH, Keightley P. Understanding quantitative genetic variation. <i>Nature
    Reviews Genetics</i>. 2002;3:11-21. doi:<a href="https://doi.org/10.1038/nrg700">10.1038/nrg700</a>
  apa: Barton, N. H., &#38; Keightley, P. (2002). Understanding quantitative genetic
    variation. <i>Nature Reviews Genetics</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nrg700">https://doi.org/10.1038/nrg700</a>
  chicago: Barton, Nicholas H, and Peter Keightley. “Understanding Quantitative Genetic
    Variation.” <i>Nature Reviews Genetics</i>. Nature Publishing Group, 2002. <a
    href="https://doi.org/10.1038/nrg700">https://doi.org/10.1038/nrg700</a>.
  ieee: N. H. Barton and P. Keightley, “Understanding quantitative genetic variation,”
    <i>Nature Reviews Genetics</i>, vol. 3. Nature Publishing Group, pp. 11–21, 2002.
  ista: Barton NH, Keightley P. 2002. Understanding quantitative genetic variation.
    Nature Reviews Genetics. 3, 11–21.
  mla: Barton, Nicholas H., and Peter Keightley. “Understanding Quantitative Genetic
    Variation.” <i>Nature Reviews Genetics</i>, vol. 3, Nature Publishing Group, 2002,
    pp. 11–21, doi:<a href="https://doi.org/10.1038/nrg700">10.1038/nrg700</a>.
  short: N.H. Barton, P. Keightley, Nature Reviews Genetics 3 (2002) 11–21.
date_created: 2018-12-11T12:07:55Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-06-06T10:07:00Z
day: '01'
doi: 10.1038/nrg700
extern: '1'
external_id:
  pmid:
  - '11823787'
intvolume: '         3'
language:
- iso: eng
month: '01'
oa_version: None
page: 11 - 21
pmid: 1
publication: Nature Reviews Genetics
publication_identifier:
  issn:
  - 1471-0056
publication_status: published
publisher: Nature Publishing Group
publist_id: '1831'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Understanding quantitative genetic variation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '2002'
...
---
_id: '4262'
abstract:
- lang: eng
  text: Natural populations are structured spatially into local populations and genetically
    into diverse ‘genetic backgrounds’ defined by different combinations of selected
    alleles. If selection maintains genetic backgrounds at constant frequency then
    neutral diversity is enhanced. By contrast, if background frequencies fluctuate
    then diversity is reduced. Provided that the population size of each background
    is large enough, these effects can be described by the structured coalescent process.
    Almost all the extant results based on the coalescent deal with a single selected
    locus. Yet we know that very large numbers of genes are under selection and that
    any substantial effects are likely to be due to the cumulative effects of many
    loci. Here, we set up a general framework for the extension of the coalescent
    to multilocus scenarios and we use it to study the simplest model, where strong
    balancing selection acting on a set of n loci maintains 2n backgrounds at constant
    frequencies and at linkage equilibrium. Analytical results show that the expected
    linked neutral diversity increases exponentially with the number of selected loci
    and can become extremely large. However, simulation results reveal that the structured
    coalescent approach breaks down when the number of backgrounds approaches the
    population size, because of stochastic fluctuations in background frequencies.
    A new method is needed to extend the structured coalescent to cases with large
    numbers of backgrounds.
acknowledgement: "We thank B. Charlesworth, D. Charlesworth and F. Depaulis for valuable
  discussion and criticism. We are also\r\ngrateful to an anonymous reviewer, who
  pointed out an imprecision in the original manuscript. This work was\r\nsupported
  by the BBSRC."
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Arcadio
  full_name: Navarro, Arcadio
  last_name: Navarro
citation:
  ama: 'Barton NH, Navarro A. Extending the coalescent to multilocus systems: the
    case of balancing selection. <i>Genetical Research</i>. 2002;79(2):129-139. doi:<a
    href="https://doi.org/10.1017/S0016672301005493">10.1017/S0016672301005493</a>'
  apa: 'Barton, N. H., &#38; Navarro, A. (2002). Extending the coalescent to multilocus
    systems: the case of balancing selection. <i>Genetical Research</i>. Cambridge
    University Press. <a href="https://doi.org/10.1017/S0016672301005493">https://doi.org/10.1017/S0016672301005493</a>'
  chicago: 'Barton, Nicholas H, and Arcadio Navarro. “Extending the Coalescent to
    Multilocus Systems: The Case of Balancing Selection.” <i>Genetical Research</i>.
    Cambridge University Press, 2002. <a href="https://doi.org/10.1017/S0016672301005493">https://doi.org/10.1017/S0016672301005493</a>.'
  ieee: 'N. H. Barton and A. Navarro, “Extending the coalescent to multilocus systems:
    the case of balancing selection,” <i>Genetical Research</i>, vol. 79, no. 2. Cambridge
    University Press, pp. 129–139, 2002.'
  ista: 'Barton NH, Navarro A. 2002. Extending the coalescent to multilocus systems:
    the case of balancing selection. Genetical Research. 79(2), 129–139.'
  mla: 'Barton, Nicholas H., and Arcadio Navarro. “Extending the Coalescent to Multilocus
    Systems: The Case of Balancing Selection.” <i>Genetical Research</i>, vol. 79,
    no. 2, Cambridge University Press, 2002, pp. 129–39, doi:<a href="https://doi.org/10.1017/S0016672301005493">10.1017/S0016672301005493</a>.'
  short: N.H. Barton, A. Navarro, Genetical Research 79 (2002) 129–139.
date_created: 2018-12-11T12:07:55Z
date_published: 2002-05-23T00:00:00Z
date_updated: 2023-06-06T11:23:19Z
day: '23'
doi: 10.1017/S0016672301005493
extern: '1'
external_id:
  pmid:
  - '12073551'
intvolume: '        79'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 129 - 139
pmid: 1
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '1832'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Extending the coalescent to multilocus systems: the case of balancing selection'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 79
year: '2002'
...
