---
_id: '2739'
abstract:
- lang: eng
text: We define the two dimensional Pauli operator and identify its core for magnetic
fields that are regular Borel measures. The magnetic field is generated by a scalar
potential hence we bypass the usual A L 2loc condition on the vector potential,
which does not allow to consider such singular fields. We extend the Aharonov-Casher
theorem for magnetic fields that are measures with finite total variation and
we present a counterexample in case of infinite total variation. One of the key
technical tools is a weighted L 2 estimate on a singular integral operator.
acknowledgement: "This work started during the first author’s visit at the Erwin Schrödinger
Institute, Vienna.\r\nValuable discussions with T. Hoffmann-Ostenhof and M. Loss
are gratefully acknowledged. The authors thank\r\nthe referee for careful reading
and comments"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Vitali
full_name: Vougalter, Vitali
last_name: Vougalter
citation:
ama: Erdös L, Vougalter V. Pauli operator and Aharonov–Casher theorem¶ for measure
valued magnetic fields. Communications in Mathematical Physics. 2002;225(2):399-421.
doi:10.1007/s002200100585
apa: Erdös, L., & Vougalter, V. (2002). Pauli operator and Aharonov–Casher theorem¶
for measure valued magnetic fields. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s002200100585
chicago: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher
Theorem¶ for Measure Valued Magnetic Fields.” Communications in Mathematical
Physics. Springer, 2002. https://doi.org/10.1007/s002200100585.
ieee: L. Erdös and V. Vougalter, “Pauli operator and Aharonov–Casher theorem¶ for
measure valued magnetic fields,” Communications in Mathematical Physics,
vol. 225, no. 2. Springer, pp. 399–421, 2002.
ista: Erdös L, Vougalter V. 2002. Pauli operator and Aharonov–Casher theorem¶ for
measure valued magnetic fields. Communications in Mathematical Physics. 225(2),
399–421.
mla: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶
for Measure Valued Magnetic Fields.” Communications in Mathematical Physics,
vol. 225, no. 2, Springer, 2002, pp. 399–421, doi:10.1007/s002200100585.
short: L. Erdös, V. Vougalter, Communications in Mathematical Physics 225 (2002)
399–421.
date_created: 2018-12-11T11:59:21Z
date_published: 2002-02-01T00:00:00Z
date_updated: 2023-07-18T08:57:54Z
day: '01'
doi: 10.1007/s002200100585
extern: '1'
external_id:
arxiv:
- math-ph/0109015v1
intvolume: ' 225'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 399 - 421
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4153'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 225
year: '2002'
...
---
_id: '2740'
abstract:
- lang: eng
text: We show that the lowest eigenvalue of the magnetic Schrödinger operator on
a line bundle over a compact Riemann surface M is bounded by the L1-norm of the
magnetic field B. This implies a similar bound on the multiplicity of the ground
state. An example shows that this degeneracy can indeed be comparable with ∫M
|B| even in case of the trivial bundle.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Spectral shift and multiplicity of the first eigenvalue of the magnetic
Schrödinger operator in two dimensions. Annales de l’Institut Fourier.
2002;52(6):1833-1874. doi:10.5802/aif.1936
apa: Erdös, L. (2002). Spectral shift and multiplicity of the first eigenvalue of
the magnetic Schrödinger operator in two dimensions. Annales de l’Institut
Fourier. Association des Annales de l’Institut Fourier. https://doi.org/10.5802/aif.1936
chicago: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue
of the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut
Fourier. Association des Annales de l’Institut Fourier, 2002. https://doi.org/10.5802/aif.1936.
ieee: L. Erdös, “Spectral shift and multiplicity of the first eigenvalue of the
magnetic Schrödinger operator in two dimensions,” Annales de l’Institut Fourier,
vol. 52, no. 6. Association des Annales de l’Institut Fourier, pp. 1833–1874,
2002.
ista: Erdös L. 2002. Spectral shift and multiplicity of the first eigenvalue of
the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier.
52(6), 1833–1874.
mla: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of
the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut
Fourier, vol. 52, no. 6, Association des Annales de l’Institut Fourier, 2002,
pp. 1833–74, doi:10.5802/aif.1936.
short: L. Erdös, Annales de l’Institut Fourier 52 (2002) 1833–1874.
date_created: 2018-12-11T11:59:21Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T08:38:34Z
day: '01'
doi: 10.5802/aif.1936
extern: '1'
intvolume: ' 52'
issue: '6'
language:
- iso: eng
month: '01'
oa_version: None
page: 1833-1874
publication: Annales de l'Institut Fourier
publication_identifier:
issn:
- 0373-0956
publication_status: published
publisher: Association des Annales de l'Institut Fourier
publist_id: '4152'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger
operator in two dimensions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '2002'
...
---
_id: '2866'
abstract:
- lang: eng
text: 'Developmental responses to the plant hormone auxin are thought to be mediated
by interacting pairs from two protein families: short-lived inhibitory IAA proteins
and ARF transcription factors binding to auxin-response elements. Monopteros mutants
lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate
the root meristem during early embryogenesis. Here we show that the bodenlos phenotype
results from an amino-acid exchange in the conserved degradation domain of IAA12.
BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes
are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS
action in root meristem initiation.'
acknowledgement: "We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth
and J. Friml for providing clones for in situ probes; K. Harter for making available
the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer,
D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript.
This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens
bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part
by payment of page charges. This article must therefore be hereby marked “advertisement”
in accordance with 18 USC section 1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Thorsten
full_name: Hamann, Thorsten
last_name: Hamann
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Isabel
full_name: Bäurle, Isabel
last_name: Bäurle
- first_name: Marika
full_name: Kientz, Marika
last_name: Kientz
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
citation:
ama: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS
gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning.
Genes and Development. 2002;16(13):1610-1615. doi:10.1101/gad.229402
apa: Hamann, T., Benková, E., Bäurle, I., Kientz, M., & Jürgens, G. (2002).
The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.229402
chicago: Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens.
“The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated
Embryo Patterning.” Genes and Development. Cold Spring Harbor Laboratory
Press, 2002. https://doi.org/10.1101/gad.229402.
ieee: T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis
BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning,” Genes and Development, vol. 16, no. 13. Cold Spring
Harbor Laboratory Press, pp. 1610–1615, 2002.
ista: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis
BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning. Genes and Development. 16(13), 1610–1615.
mla: Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response
Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” Genes and Development,
vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:10.1101/gad.229402.
short: T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development
16 (2002) 1610–1615.
date_created: 2018-12-11T12:00:01Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2023-07-18T08:26:58Z
day: '01'
doi: 10.1101/gad.229402
extern: '1'
external_id:
pmid:
- '12101120'
intvolume: ' 16'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/
month: '07'
oa: 1
oa_version: Published Version
page: 1610 - 1615
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting
MONOPTEROS-mediated embryo patterning
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2002'
...
---
_id: '2927'
abstract:
- lang: eng
text: 'In the last few years, several new algorithms based on graph cuts have been
developed to solve energy minimization problems in computer vision. Each of these
techniques constructs a graph such that the minimum cut on the graph also minimizes
the energy. Yet because these graph constructions are complex and highly specific
to a particular energy function, graph cuts have seen limited application to date.
In this paper we characterize the energy functions that can be minimized by graph
cuts. Our results are restricted to energy functions with binary variables. However,
our work generalizes many previous constructions, and is easily applicable to
vision problems that involve large numbers of labels, such as stereo, motion,
image restoration and scene reconstruction. We present three main results: a necessary
condition for any energy function that can be minimized by graph cuts; a sufficient
condition for energy functions that can be written as a sum of functions of up
to three variables at a time; and a general-purpose construction to minimize such
an energy function. Researchers who are considering the use of graph cuts to optimize
a particular energy function can use our results to determine if this is possible,
and then follow our construction to create the appropriate graph.'
acknowledgement: We thank Olga Veksler and Yuri Boykov for their careful reading of
this paper, and for valuable comments which greatly improved itsreadibility. We
also thank Ian Jermyn for helping us clarify the paper’s motivation. This research
was supported by NSF grants IIS-9900115 and CCR-0113371, and by a grant from Microsoft
Research.
article_processing_charge: No
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: Ramin
full_name: Zabih, Ramin
last_name: Zabih
citation:
ama: 'Kolmogorov V, Zabih R. Multi-camera scene reconstruction via graph cuts. In:
Proceedings of the 7th European Conference on Computer Vision. Springer;
2002:65-81. doi:10.1007/3-540-47977-5_5'
apa: 'Kolmogorov, V., & Zabih, R. (2002). Multi-camera scene reconstruction
via graph cuts. In Proceedings of the 7th European Conference on Computer Vision
(pp. 65–81). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-47977-5_5'
chicago: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction
via Graph Cuts.” In Proceedings of the 7th European Conference on Computer
Vision, 65–81. Springer, 2002. https://doi.org/10.1007/3-540-47977-5_5.
ieee: V. Kolmogorov and R. Zabih, “Multi-camera scene reconstruction via graph cuts,”
in Proceedings of the 7th European Conference on Computer Vision, Copenhagen,
Denmark, 2002, pp. 65–81.
ista: 'Kolmogorov V, Zabih R. 2002. Multi-camera scene reconstruction via graph
cuts. Proceedings of the 7th European Conference on Computer Vision. ECCV: European
Conference on Computer Vision, 65–81.'
mla: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via
Graph Cuts.” Proceedings of the 7th European Conference on Computer Vision,
Springer, 2002, pp. 65–81, doi:10.1007/3-540-47977-5_5.
short: V. Kolmogorov, R. Zabih, in:, Proceedings of the 7th European Conference
on Computer Vision, Springer, 2002, pp. 65–81.
conference:
end_date: 2002-05-31
location: Copenhagen, Denmark
name: 'ECCV: European Conference on Computer Vision'
start_date: 2002-05-28
date_created: 2018-12-11T12:00:23Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T08:20:02Z
day: '01'
doi: 10.1007/3-540-47977-5_5
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 65 - 81
publication: Proceedings of the 7th European Conference on Computer Vision
publication_identifier:
isbn:
- '9783540437468'
publication_status: published
publisher: Springer
publist_id: '3810'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multi-camera scene reconstruction via graph cuts
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2986'
abstract:
- lang: eng
text: Long-standing models propose that plant growth responses to light or gravity
are mediated by asymmetric distribution of the phytohormone auxin. Physiological
studies implicated a specific transport system that relocates auxin laterally,
thereby effecting differential growth; however, neither the molecular components
of this system nor the cellular mechanism of auxin redistribution on light or
gravity perception have been identified. Here, we show that auxin accumulates
asymmetrically during differential growth in an efflux-dependent manner. Mutations
in the Arabidopsis gene PIN3, a regulator of auxin efflux, alter differential
growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating
predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane
and to vesicles that cycle in an actin-dependent manner. In the root columella,
PIN3 is positioned symmetrically at the plasma membrane but rapidly relocalizes
laterally on gravity stimulation. Our data indicate that PIN3 is a component of
the lateral auxin transport system regulating tropic growth. In addition, actin-dependent
relocalization of PIN3 in response to gravity provides a mechanism for redirecting
auxin flux to trigger asymmetric growth.
acknowledgement: We thank G. Jürgens for enabling J.F. to accomplish part of this
work in his laboratory; P. Tänzler and M. Sauer for technical assistance; H. Vahlenkamp
for technical assistance in immunocytochemistry; M. Estelle for providing material
and suggestions; T. Altman for BAC filter sets; the ADIS (Automated DNA Isolation
and Sequencing) service group for DNA sequencing; ZIGIA (Center for Functional Genomics
in Arabidopsis) for the En lines; and N. Geldner, T. Hamann, G. Jürgens, K. Schrick
and C. Schwechheimer for comments and critical reading of the manuscript. This work
was supported by a fellowship of the DAAD (J.F.), the DFG (Schwerpunktprogramm Phytohormone),
the Fonds der chemischen Industrie, the European Communities Biotechnology Programs,
the INCO-Copernicus Program and the European Space Agency MAP-Biotechnology Programme
article_processing_charge: No
article_type: original
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Justyna
full_name: Wiśniewska, Justyna
last_name: Wiśniewska
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Kurt
full_name: Mendgen, Kurt
last_name: Mendgen
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. Lateral relocation of
auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 2002;415(6873):806-809.
doi:10.1038/415806a
apa: Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., & Palme, K. (2002).
Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis.
Nature. Nature Publishing Group. https://doi.org/10.1038/415806a
chicago: Friml, Jiří, Justyna Wiśniewska, Eva Benková, Kurt Mendgen, and Klaus Palme.
“Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.”
Nature. Nature Publishing Group, 2002. https://doi.org/10.1038/415806a.
ieee: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, and K. Palme, “Lateral relocation
of auxin efflux regulator PIN3 mediates tropism in Arabidopsis,” Nature,
vol. 415, no. 6873. Nature Publishing Group, pp. 806–809, 2002.
ista: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. 2002. Lateral relocation
of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 415(6873),
806–809.
mla: Friml, Jiří, et al. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates
Tropism in Arabidopsis.” Nature, vol. 415, no. 6873, Nature Publishing
Group, 2002, pp. 806–09, doi:10.1038/415806a.
short: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, K. Palme, Nature 415 (2002)
806–809.
date_created: 2018-12-11T12:00:42Z
date_published: 2002-02-14T00:00:00Z
date_updated: 2023-07-18T07:30:27Z
day: '14'
doi: 10.1038/415806a
extern: '1'
external_id:
pmid:
- '11845211 '
intvolume: ' 415'
issue: '6873'
language:
- iso: eng
month: '02'
oa_version: None
page: 806 - 809
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '3715'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 415
year: '2002'
...
---
_id: '2987'
abstract:
- lang: eng
text: The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype
that shows defective embryonic and seedling cell patterning, morphogenesis, and
root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase,
whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL
gene product. Seedlings mutant for each gene are similarly defective in the concentrations
of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed
misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal
cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses
to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene
signaling but not by exogenous sterols or brassinosteroids. We propose a model
in which correct sterol profiles are required for regulated auxin and ethylene
signaling through effects on membrane function.
acknowledgement: We thank Dr. Ken Feldmann for providing prospective hyd alleles,
Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing
ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline
Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham
Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological
Science Research Council research studentship to M.S., a Durham University studentship
to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330
to J.T.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
full_name: Souter, Martin
last_name: Souter
- first_name: Jennifer
full_name: Topping, Jennifer
last_name: Topping
- first_name: Margaret
full_name: Pullen, Margaret
last_name: Pullen
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Rachel
full_name: Hackett, Rachel
last_name: Hackett
- first_name: Don
full_name: Grierson, Don
last_name: Grierson
- first_name: Keith
full_name: Lindsey, Keith
last_name: Lindsey
citation:
ama: Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective
in sterol profiles and auxin and ethylene signaling. Plant Cell. 2002;14(5):1017-1031.
doi:10.1105/tpc.001248
apa: Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey,
K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
and ethylene signaling. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.001248
chicago: Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme,
Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis
Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” Plant Cell.
American Society of Plant Biologists, 2002. https://doi.org/10.1105/tpc.001248.
ieee: M. Souter et al., “Hydra mutants of Arabidopsis are defective in sterol
profiles and auxin and ethylene signaling,” Plant Cell, vol. 14, no. 5.
American Society of Plant Biologists, pp. 1017–1031, 2002.
ista: Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey
K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
and ethylene signaling. Plant Cell. 14(5), 1017–1031.
mla: Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol
Profiles and Auxin and Ethylene Signaling.” Plant Cell, vol. 14, no. 5,
American Society of Plant Biologists, 2002, pp. 1017–31, doi:10.1105/tpc.001248.
short: M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson,
K. Lindsey, Plant Cell 14 (2002) 1017–1031.
date_created: 2018-12-11T12:00:42Z
date_published: 2002-05-01T00:00:00Z
date_updated: 2023-07-18T07:34:32Z
day: '01'
doi: 10.1105/tpc.001248
extern: '1'
external_id:
pmid:
- '12034894'
intvolume: ' 14'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/
month: '05'
oa: 1
oa_version: None
page: 1017 - 1031
pmid: 1
publication: Plant Cell
publication_identifier:
issn:
- 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3716'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and
ethylene signaling
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 14
year: '2002'
...
---
_id: '2988'
abstract:
- lang: eng
text: Coordination of cell and tissue polarity commonly involves directional signaling
[1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root
tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant
hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration
in the root tip [4, 5]. The application of polar auxin transport inhibitors [3]
evokes changes in trichoblast polarity only at high concentrations and after long-term
application [2, 4]. Thus, it remains open whether components of the auxin transport
machinery mediate establishment of trichoblast polarity. Here we report that the
presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair
cell polarity. AUX1 function is required for polarity changes induced by exogenous
application of the auxin 2,4-D, a preferential influx carrier substrate. Similar
to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes
with polar hair initiation, and AUX1 function is required for BFA-mediated polarity
changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast
hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results
identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway
polarizing cells toward a hormone maximum.
article_processing_charge: No
article_type: original
author:
- first_name: Markus
full_name: Grebe, Markus
last_name: Grebe
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Maarten
full_name: Terlou, Maarten
last_name: Terlou
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
citation:
ama: Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves
a BFA sensitive auxin influx pathway. Current Biology. 2002;12(4):329-334.
doi:10.1016/S0960-9822(02)00654-1
apa: Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres,
B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin
influx pathway. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00654-1
chicago: Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg,
Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity
Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” Current
Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)00654-1.
ieee: M. Grebe et al., “Cell polarity signaling in Arabidopsis involves a
BFA sensitive auxin influx pathway,” Current Biology, vol. 12, no. 4. Cell
Press, pp. 329–334, 2002.
ista: Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett
M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive
auxin influx pathway. Current Biology. 12(4), 329–334.
mla: Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA
Sensitive Auxin Influx Pathway.” Current Biology, vol. 12, no. 4, Cell
Press, 2002, pp. 329–34, doi:10.1016/S0960-9822(02)00654-1.
short: M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme,
M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334.
date_created: 2018-12-11T12:00:43Z
date_published: 2002-02-19T00:00:00Z
date_updated: 2023-07-17T12:15:28Z
day: '19'
doi: 10.1016/S0960-9822(02)00654-1
extern: '1'
external_id:
pmid:
- '11864575'
intvolume: ' 12'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 329 - 334
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '3714'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx
pathway
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2989'
abstract:
- lang: eng
text: In contrast to animals, little is known about pattern formation in plants.
Physiological and genetic data suggest the involvement of the phytohormone auxin
in this process. Here, we characterize a novel member of the PIN family of putative
auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature
root meristems. Atpin4 mutants are defective in establishment and maintenance
of endogenous auxin gradients, fail to canalize externally applied auxin, and
display various patterning defects in both embryonic and seedling roots. We propose
a role for AtPIN4 in generating a sink for auxin below the quiescent center of
the root meristem that is essential for auxin distribution and patterning.
acknowledgement: We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for
technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus,
OH) and Thomas Altman for providing material. We also gratefully acknowledge the
ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics
in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly
Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading
of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer
Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm
Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen
Industrie, and the INCO-Copernicus Program.
article_processing_charge: No
article_type: original
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Ikram
full_name: Blilou, Ikram
last_name: Blilou
- first_name: Justyna
full_name: Wiśniewska, Justyna
last_name: Wiśniewska
- first_name: Thorsten
full_name: Hamann, Thorsten
last_name: Hamann
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Scott
full_name: Woody, Scott
last_name: Woody
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients
and root patterning in Arabidopsis. Cell. 2002;108(5):661-673. doi:10.1016/S0092-8674(02)00656-6
apa: Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K.,
… Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning
in Arabidopsis. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(02)00656-6
chicago: Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann,
Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients
and Root Patterning in Arabidopsis.” Cell. Cell Press, 2002. https://doi.org/10.1016/S0092-8674(02)00656-6.
ieee: J. Friml et al., “AtPIN4 mediates sink-driven auxin gradients and root
patterning in Arabidopsis,” Cell, vol. 108, no. 5. Cell Press, pp. 661–673,
2002.
ista: Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg
G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients
and root patterning in Arabidopsis. Cell. 108(5), 661–673.
mla: Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning
in Arabidopsis.” Cell, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:10.1016/S0092-8674(02)00656-6.
short: J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody,
G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673.
date_created: 2018-12-11T12:00:43Z
date_published: 2002-03-08T00:00:00Z
date_updated: 2023-07-17T11:57:40Z
day: '08'
doi: 10.1016/S0092-8674(02)00656-6
extern: '1'
external_id:
pmid:
- '11893337'
intvolume: ' 108'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: None
page: 661 - 673
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '3713'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '2002'
...
---
_id: '2991'
abstract:
- lang: eng
text: Polar auxin transport controls multiple aspects of plant development including
differential growth, embryo and root patterning and vascular tissue differentiation.
Identification of proteins involved in this process and availability of new tools
enabling `visualization' of auxin and auxin routes in planta largely contributed
to the significant progress that has recently been made. New data support classical
concepts, but several recent findings are likely to challenge our view on the
mechanism of auxin transport. The aim of this review is to provide a comprehensive
overview of the polar auxin transport field. It starts with classical models resulting
from physiological studies, describes the genetic contributions and discusses
the molecular basis of auxin influx and efflux. Finally, selected questions are
presented in the context of developmental biology, integrating available data
from different fields.
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Friml J, Palme K. Polar auxin transport - Old questions and new concepts? Plant
Molecular Biology. 2002;49(3-4):273-284. doi:10.1023/A:1015248926412
apa: Friml, J., & Palme, K. (2002). Polar auxin transport - Old questions and
new concepts? Plant Molecular Biology. Springer. https://doi.org/10.1023/A:1015248926412
chicago: Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and
New Concepts?” Plant Molecular Biology. Springer, 2002. https://doi.org/10.1023/A:1015248926412.
ieee: J. Friml and K. Palme, “Polar auxin transport - Old questions and new concepts?,”
Plant Molecular Biology, vol. 49, no. 3–4. Springer, pp. 273–284, 2002.
ista: Friml J, Palme K. 2002. Polar auxin transport - Old questions and new concepts?
Plant Molecular Biology. 49(3–4), 273–284.
mla: Friml, Jiří, and Klaus Palme. “Polar Auxin Transport - Old Questions and New
Concepts?” Plant Molecular Biology, vol. 49, no. 3–4, Springer, 2002, pp.
273–84, doi:10.1023/A:1015248926412.
short: J. Friml, K. Palme, Plant Molecular Biology 49 (2002) 273–284.
date_created: 2018-12-11T12:00:44Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2021-01-12T07:40:17Z
day: '01'
doi: 10.1023/A:1015248926412
extern: '1'
intvolume: ' 49'
issue: 3-4
language:
- iso: eng
month: '06'
oa_version: None
page: 273 - 284
publication: Plant Molecular Biology
publication_status: published
publisher: Springer
publist_id: '3712'
quality_controlled: '1'
status: public
title: Polar auxin transport - Old questions and new concepts?
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2002'
...
---
_id: '3140'
abstract:
- lang: eng
text: The maturation of synaptic structures depends on inductive interactions between
axons and their prospective targets. One example of such an interaction is the
influence of proprioceptive sensory axons on the differentiation of muscle spindles.
We have monitored the expression of three transcription factors, Egr3, Pea3, and
Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing
signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive
afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1
isoforms are preferentially expressed by proprioceptive sensory neurons and are
sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1
isoforms are broadly expressed in sensory and motor neurons but are not required
for muscle spindle induction.
acknowledgement: We thank L. Role for generously providing the CRD-Nrg1 mutant allele
for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse
strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert
technical assistance, X. Yang for experimental help in the initial phase of these
studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach
for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of
Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported
by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt.
S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard
Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development
Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator
of the Howard Hughes Medical Institute.
article_processing_charge: No
article_type: original
author:
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Neil
full_name: Shneider, Neil
last_name: Shneider
- first_name: Carmen
full_name: Birchmeier, Carmen
last_name: Birchmeier
- first_name: Steven
full_name: Burden, Steven
last_name: Burden
- first_name: Thomas
full_name: Jessell, Thomas
last_name: Jessell
- first_name: Silvia
full_name: Arber, Silvia
last_name: Arber
citation:
ama: Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role
for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36(6):1035-1049.
doi:10.1016/S0896-6273(02)01101-7
apa: Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., &
Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation.
Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)01101-7
chicago: Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas
Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle
Differentiation.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)01101-7.
ieee: S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S.
Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” Neuron,
vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002.
ista: Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002.
A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6),
1035–1049.
mla: Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle
Differentiation.” Neuron, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49,
doi:10.1016/S0896-6273(02)01101-7.
short: S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, S. Arber,
Neuron 36 (2002) 1035–1049.
date_created: 2018-12-11T12:01:37Z
date_published: 2002-12-19T00:00:00Z
date_updated: 2023-07-17T11:46:43Z
day: '19'
doi: 10.1016/S0896-6273(02)01101-7
extern: '1'
external_id:
pmid:
- '12495620'
intvolume: ' 36'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 1035 - 1049
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '3558'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A role for Neuregulin1 signaling in muscle spindle differentiation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 36
year: '2002'
...
---
_id: '3421'
abstract:
- lang: eng
text: Single molecule experiments provide insight into the individuality of biological
macromolecules, their unique function, reaction pathways, trajectories and molecular
interactions. The exceptional signal-to-noise ratio of the atomic force microscope
allows individual proteins to be imaged under physiologically relevant conditions
at a lateral resolution of 0.5–1 nm and a vertical resolution of 0.1–0.2 nm. Recently,
it has become possible to observe single molecule events using this technique.
This capability is reviewed on various water-soluble and membrane proteins. Examples
of the observation of function, variability, and assembly of single proteins are
discussed. Statistical analysis is important to extend conclusions derived from
single molecule experiments to protein species. Such approaches allow the classification
of protein conformations and movements. Recent developments of probe microscopy
techniques allow simultaneous measurement of multiple signals on individual macromolecules,
and greatly extend the range of experiments possible for probing biological systems
at the molecular level. Biologists exploring molecular mechanisms will benefit
from a burgeoning of scanning probe microscopes and of their future combination
with molecular biological experiments.
article_processing_charge: No
article_type: review
author:
- first_name: Daniel
full_name: Mueller, Daniel
last_name: Mueller
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Tiina
full_name: Lehto, Tiina
last_name: Lehto
- first_name: Lars
full_name: Kuerschner, Lars
last_name: Kuerschner
- first_name: Kurt
full_name: Anderson, Kurt
last_name: Anderson
citation:
ama: Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. Observing structure,
function and assembly of single proteins by AFM. Progress in Biophysics and
Molecular Biology. 2002;79(1-3):1-43. doi:10.1016/S0079-6107(02)00009-3
apa: Mueller, D., Janovjak, H. L., Lehto, T., Kuerschner, L., & Anderson, K.
(2002). Observing structure, function and assembly of single proteins by AFM.
Progress in Biophysics and Molecular Biology. Elsevier. https://doi.org/10.1016/S0079-6107(02)00009-3
chicago: Mueller, Daniel, Harald L Janovjak, Tiina Lehto, Lars Kuerschner, and Kurt
Anderson. “Observing Structure, Function and Assembly of Single Proteins by AFM.”
Progress in Biophysics and Molecular Biology. Elsevier, 2002. https://doi.org/10.1016/S0079-6107(02)00009-3.
ieee: D. Mueller, H. L. Janovjak, T. Lehto, L. Kuerschner, and K. Anderson, “Observing
structure, function and assembly of single proteins by AFM,” Progress in Biophysics
and Molecular Biology, vol. 79, no. 1–3. Elsevier, pp. 1–43, 2002.
ista: Mueller D, Janovjak HL, Lehto T, Kuerschner L, Anderson K. 2002. Observing
structure, function and assembly of single proteins by AFM. Progress in Biophysics
and Molecular Biology. 79(1–3), 1–43.
mla: Mueller, Daniel, et al. “Observing Structure, Function and Assembly of Single
Proteins by AFM.” Progress in Biophysics and Molecular Biology, vol. 79,
no. 1–3, Elsevier, 2002, pp. 1–43, doi:10.1016/S0079-6107(02)00009-3.
short: D. Mueller, H.L. Janovjak, T. Lehto, L. Kuerschner, K. Anderson, Progress
in Biophysics and Molecular Biology 79 (2002) 1–43.
date_created: 2018-12-11T12:03:14Z
date_published: 2002-05-01T00:00:00Z
date_updated: 2023-07-17T11:36:32Z
day: '01'
doi: 10.1016/S0079-6107(02)00009-3
extern: '1'
external_id:
pmid:
- '12225775'
intvolume: ' 79'
issue: 1-3
language:
- iso: eng
month: '05'
oa_version: None
page: 1 - 43
pmid: 1
publication: Progress in Biophysics and Molecular Biology
publication_identifier:
issn:
- 0079-6107
publication_status: published
publisher: Elsevier
publist_id: '2980'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Observing structure, function and assembly of single proteins by AFM
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 79
year: '2002'
...
---
_id: '3422'
abstract:
- lang: eng
text: Quantitative real-time PCR represents a highly sensitive and powerful technique
for the quantitation of nucleic acids. It has a tremendous potential for the high-throughput
analysis of gene expression in research and routine diagnostics. However, the
major hurdle is not the practical performance of the experiments themselves but
rather the efficient evaluation and the mathematical and statistical analysis
of the enormous amount of data gained by this technology, as these functions are
not included in the software provided by the manufacturers of the detection systems.
In this work, we focus on the mathematical evaluation and analysis of the data
generated by quantitative real-time PCR, the calculation of the final results,
the propagation of experimental variation of the measured values to the final
results, and the statistical analysis. We developed a Microsoft Excel-based software
application coded in Visual Basic for Applications, called Q-Gene, which addresses
these points. Q-Gene manages and expedites the planning, performance, and evaluation
of quantitative real-time PCR experiments, as well as the mathematical and statistical
analysis, storage, and graphical presentation of the data. The Q-Gene software
application is a tool to cope with complex quantitative real-time PCR experiments
at a high-throughput scale and considerably expedites and rationalizes the experimental
setup, data analysis, and data management while ensuring highest reproducibility.
article_processing_charge: No
article_type: original
author:
- first_name: Patrick
full_name: Müller, Patrick
last_name: Müller
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Andre
full_name: Miserez, Andre
last_name: Miserez
- first_name: Zuzana
full_name: Dobbie, Zuzana
last_name: Dobbie
citation:
ama: Müller P, Janovjak HL, Miserez A, Dobbie Z. Processing of gene expression data
generated by quantitative real-time RT-PCR. Biotechniques. 2002;32(6):1372-1379.
apa: Müller, P., Janovjak, H. L., Miserez, A., & Dobbie, Z. (2002). Processing
of gene expression data generated by quantitative real-time RT-PCR. Biotechniques.
Informa Healthcare.
chicago: Müller, Patrick, Harald L Janovjak, Andre Miserez, and Zuzana Dobbie. “Processing
of Gene Expression Data Generated by Quantitative Real-Time RT-PCR.” Biotechniques.
Informa Healthcare, 2002.
ieee: P. Müller, H. L. Janovjak, A. Miserez, and Z. Dobbie, “Processing of gene
expression data generated by quantitative real-time RT-PCR,” Biotechniques,
vol. 32, no. 6. Informa Healthcare, pp. 1372–1379, 2002.
ista: Müller P, Janovjak HL, Miserez A, Dobbie Z. 2002. Processing of gene expression
data generated by quantitative real-time RT-PCR. Biotechniques. 32(6), 1372–1379.
mla: Müller, Patrick, et al. “Processing of Gene Expression Data Generated by Quantitative
Real-Time RT-PCR.” Biotechniques, vol. 32, no. 6, Informa Healthcare, 2002,
pp. 1372–79.
short: P. Müller, H.L. Janovjak, A. Miserez, Z. Dobbie, Biotechniques 32 (2002)
1372–1379.
date_created: 2018-12-11T12:03:15Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-07-17T11:29:06Z
day: '01'
extern: '1'
external_id:
pmid:
- '12074169'
intvolume: ' 32'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 1372 - 1379
pmid: 1
publication: Biotechniques
publication_identifier:
issn:
- 0736-6205
publication_status: published
publisher: Informa Healthcare
publist_id: '2979'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Processing of gene expression data generated by quantitative real-time RT-PCR
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 32
year: '2002'
...
---
_id: '3423'
article_processing_charge: No
author:
- first_name: Wolfgang
full_name: Bauer, Wolfgang
last_name: Bauer
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Marko
full_name: Kleine Berkenbusch, Marko
last_name: Kleine Berkenbusch
- first_name: Holger
full_name: Harreis, Holger
last_name: Harreis
citation:
ama: 'Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. The percolation interpretation
of the nuclear fragmentation phase transition. In: Proceedings of the 18th
Winter Workshop on Nuclear Dynamics. EP Systema; 2002:111-118.'
apa: 'Bauer, W., Bollenbach, M. T., Kleine Berkenbusch, M., & Harreis, H. (2002).
The percolation interpretation of the nuclear fragmentation phase transition.
In Proceedings of the 18th Winter Workshop on Nuclear Dynamics (pp. 111–118).
Nassau, Bahamas: EP Systema.'
chicago: Bauer, Wolfgang, Mark Tobias Bollenbach, Marko Kleine Berkenbusch, and
Holger Harreis. “The Percolation Interpretation of the Nuclear Fragmentation Phase
Transition.” In Proceedings of the 18th Winter Workshop on Nuclear Dynamics,
111–18. EP Systema, 2002.
ieee: W. Bauer, M. T. Bollenbach, M. Kleine Berkenbusch, and H. Harreis, “The percolation
interpretation of the nuclear fragmentation phase transition,” in Proceedings
of the 18th Winter Workshop on Nuclear Dynamics, Nassau, Bahamas, 2002, pp.
111–118.
ista: Bauer W, Bollenbach MT, Kleine Berkenbusch M, Harreis H. 2002. The percolation
interpretation of the nuclear fragmentation phase transition. Proceedings of the
18th Winter Workshop on Nuclear Dynamics. Winter Workshop on Nuclear Dynamics,
111–118.
mla: Bauer, Wolfgang, et al. “The Percolation Interpretation of the Nuclear Fragmentation
Phase Transition.” Proceedings of the 18th Winter Workshop on Nuclear Dynamics,
EP Systema, 2002, pp. 111–18.
short: W. Bauer, M.T. Bollenbach, M. Kleine Berkenbusch, H. Harreis, in:, Proceedings
of the 18th Winter Workshop on Nuclear Dynamics, EP Systema, 2002, pp. 111–118.
conference:
end_date: 2002-01-22
location: Nassau, Bahamas
name: Winter Workshop on Nuclear Dynamics
start_date: 2002-01-20
date_created: 2018-12-11T12:03:15Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-17T11:15:14Z
day: '01'
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 111 - 118
publication: Proceedings of the 18th Winter Workshop on Nuclear Dynamics
publication_status: published
publisher: EP Systema
publist_id: '2978'
status: public
title: The percolation interpretation of the nuclear fragmentation phase transition
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '3424'
abstract:
- lang: eng
text: "We give a brief overview of the current understanding of the explosion mechanism
of core collapse supernovae. Our main focus is the impact of rotation on the explosion.
Recent observations of the polarization of the light emitted by supernova explosions
indicate that there are large deviations from spherical symmetry in the very heart
of the explosion the origin of which is unknown. We use the new approach of a
three dimensional test particle based simulation to simulate the infall phase
of a supernova event. The underlying microphysics is simplified to make this computationally
possible. A systematic study of the influence of rotation mainly during the infall
phase of the collapse of a typical iron core is performed. Indications for significant
deviations from spherical symmetry are found in our very rapidly rotating models.
© 2002 American Institute of Physics\r\n"
alternative_title:
- Exotic Clustering, American Institute of Physics Conference Proceedings
article_processing_charge: No
author:
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Wolfgang
full_name: Bauer, Wolfgang
last_name: Bauer
citation:
ama: 'Bollenbach MT, Bauer W. 3d supernovae collapse calculations. In: Vol 644.
American Institute of Physics; 2002:219-232. doi:10.1063/1.1523196 '
apa: 'Bollenbach, M. T., & Bauer, W. (2002). 3d supernovae collapse calculations
(Vol. 644, pp. 219–232). Presented at the CRIS: Catania Relativistic Ion Studies
, Catania, Italy: American Institute of Physics. https://doi.org/10.1063/1.1523196 '
chicago: Bollenbach, Mark Tobias, and Wolfgang Bauer. “3d Supernovae Collapse Calculations,”
644:219–32. American Institute of Physics, 2002. https://doi.org/10.1063/1.1523196 .
ieee: 'M. T. Bollenbach and W. Bauer, “3d supernovae collapse calculations,” presented
at the CRIS: Catania Relativistic Ion Studies , Catania, Italy, 2002, vol. 644,
pp. 219–232.'
ista: 'Bollenbach MT, Bauer W. 2002. 3d supernovae collapse calculations. CRIS:
Catania Relativistic Ion Studies , Exotic Clustering, American Institute of Physics
Conference Proceedings, vol. 644, 219–232.'
mla: Bollenbach, Mark Tobias, and Wolfgang Bauer. 3d Supernovae Collapse Calculations.
Vol. 644, American Institute of Physics, 2002, pp. 219–32, doi:10.1063/1.1523196 .
short: M.T. Bollenbach, W. Bauer, in:, American Institute of Physics, 2002, pp.
219–232.
conference:
end_date: 2002-06-14
location: Catania, Italy
name: 'CRIS: Catania Relativistic Ion Studies '
start_date: 2002-06-10
date_created: 2018-12-11T12:03:15Z
date_published: 2002-11-26T00:00:00Z
date_updated: 2023-07-17T11:05:27Z
day: '26'
doi: '10.1063/1.1523196 '
extern: '1'
intvolume: ' 644'
language:
- iso: eng
month: '11'
oa_version: None
page: 219 - 232
publication_identifier:
isbn:
- '9781510832008'
publication_status: published
publisher: American Institute of Physics
publist_id: '2977'
quality_controlled: '1'
status: public
title: 3d supernovae collapse calculations
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 644
year: '2002'
...
---
_id: '3448'
author:
- first_name: Sanhita
full_name: Mallick, Sanhita
last_name: Mallick
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Arif
full_name: Merchant, Arif N
last_name: Merchant
- first_name: Pallab
full_name: Dasgupta, Pallab
last_name: Dasgupta
citation:
ama: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. Implementation of shape grammar
for plan analysis. In: Elsevier; 2002.'
apa: 'Mallick, S., Chatterjee, K., Merchant, A., & Dasgupta, P. (2002). Implementation
of shape grammar for plan analysis. Presented at the IT-Built: Information Technology
For Built Environment, Elsevier.'
chicago: Mallick, Sanhita, Krishnendu Chatterjee, Arif Merchant, and Pallab Dasgupta.
“Implementation of Shape Grammar for Plan Analysis.” Elsevier, 2002.
ieee: 'S. Mallick, K. Chatterjee, A. Merchant, and P. Dasgupta, “Implementation
of shape grammar for plan analysis,” presented at the IT-Built: Information Technology
For Built Environment, 2002.'
ista: 'Mallick S, Chatterjee K, Merchant A, Dasgupta P. 2002. Implementation of
shape grammar for plan analysis. IT-Built: Information Technology For Built Environment.'
mla: Mallick, Sanhita, et al. Implementation of Shape Grammar for Plan Analysis.
Elsevier, 2002.
short: S. Mallick, K. Chatterjee, A. Merchant, P. Dasgupta, in:, Elsevier, 2002.
conference:
name: 'IT-Built: Information Technology For Built Environment'
date_created: 2018-12-11T12:03:23Z
date_published: 2002-01-15T00:00:00Z
date_updated: 2021-01-12T07:43:31Z
day: '15'
extern: 1
month: '01'
publication_status: published
publisher: Elsevier
publist_id: '2939'
quality_controlled: 0
status: public
title: Implementation of shape grammar for plan analysis
type: conference
year: '2002'
...
---
_id: '3497'
abstract:
- lang: eng
text: The use of advanced patch-clamp recording techniques in brain slices, such
as simultaneous recording from multiple neurons and recording from dendrites or
presynaptic terminals, demands slices of the highest quality. In this context
the mechanics of the tissue slicer are an important factor. Ideally, a tissue
slicer should generate large-amplitude and high-frequency movements of the cutting
blade in a horizontal axis, with minimal vibrations in the vertical axis. We developed
a vibroslicer that fulfils these in part conflicting requirements. The oscillator
is a permanent-magnet-coil-leaf-spring system. Using an auto-resonant mechano-electrical
feedback circuit, large horizontal oscillations (up to 3 mm peak-to-peak) with
high frequency (,90 Hz) are generated. To minimize vertical vibrations, an adjustment
mechanism was employed that allowed alignment of the cutting edge of the blade
with the major axis of the oscillation. A vibroprobe device was used to monitor
vertical vibrations during adjustment. The system is based on the shading of the
light path between a light-emitting diode (LED) and a photodiode. Vibroprobe monitoring
revealed that the vibroslicer, after appropriate adjustment, generated vertical
vibrations of <1 µm, significantly less than many commercial tissue slicers.
Light- and electron-microscopic analysis of surface layers of slices cut with
the vibroslicer showed that cellular elements, dendritic processes and presynaptic
terminals are well preserved under these conditions, as required for patch-clamp
recording from these structures.
acknowledgement: "We thank Dr. M. Frotscher for reading the manuscript, and H. Kressner,
R. Laufersweiler, and A. Bühler for help with the construction of several prototypes
of vibroslicer and vibroprobe. We also thank A. Blomenkamp, K. Winterhalter, B.
Joch, and A. Schneider for technical assistance. This work was supported by grants
of the Deutsche Forschungsgemeinschaft\r\n(SFB 505/C5, C6) and the Human Frontiers
Science Program Organization (RG0017/1998-B)."
article_processing_charge: No
article_type: original
author:
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Ulrich
full_name: Fröbe, Ulrich
last_name: Fröbe
- first_name: S
full_name: Pfitzinger, S
last_name: Pfitzinger
- first_name: H.
full_name: Weber, H.
last_name: Weber
- first_name: Klaus
full_name: Haverkampf, Klaus
last_name: Haverkampf
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Geiger J, Bischofberger J, Vida I, et al. Patch-clamp recording in brain slices
with improved slicer technology. Pflugers Archiv : European Journal of Physiology.
2002;443(3):491-501. doi:10.1007/s00424-001-0735-3'
apa: 'Geiger, J., Bischofberger, J., Vida, I., Fröbe, U., Pfitzinger, S., Weber,
H., … Jonas, P. M. (2002). Patch-clamp recording in brain slices with improved
slicer technology. Pflugers Archiv : European Journal of Physiology. Springer.
https://doi.org/10.1007/s00424-001-0735-3'
chicago: 'Geiger, Jörg, Joseph Bischofberger, Imre Vida, Ulrich Fröbe, S Pfitzinger,
H. Weber, Klaus Haverkampf, and Peter M Jonas. “Patch-Clamp Recording in Brain
Slices with Improved Slicer Technology.” Pflugers Archiv : European Journal
of Physiology. Springer, 2002. https://doi.org/10.1007/s00424-001-0735-3.'
ieee: 'J. Geiger et al., “Patch-clamp recording in brain slices with improved
slicer technology,” Pflugers Archiv : European Journal of Physiology, vol.
443, no. 3. Springer, pp. 491–501, 2002.'
ista: 'Geiger J, Bischofberger J, Vida I, Fröbe U, Pfitzinger S, Weber H, Haverkampf
K, Jonas PM. 2002. Patch-clamp recording in brain slices with improved slicer
technology. Pflugers Archiv : European Journal of Physiology. 443(3), 491–501.'
mla: 'Geiger, Jörg, et al. “Patch-Clamp Recording in Brain Slices with Improved
Slicer Technology.” Pflugers Archiv : European Journal of Physiology, vol.
443, no. 3, Springer, 2002, pp. 491–501, doi:10.1007/s00424-001-0735-3.'
short: 'J. Geiger, J. Bischofberger, I. Vida, U. Fröbe, S. Pfitzinger, H. Weber,
K. Haverkampf, P.M. Jonas, Pflugers Archiv : European Journal of Physiology 443
(2002) 491–501.'
date_created: 2018-12-11T12:03:38Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-17T07:36:37Z
day: '01'
doi: 10.1007/s00424-001-0735-3
extern: '1'
external_id:
pmid:
- '11810221'
intvolume: ' 443'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 491 - 501
pmid: 1
publication: 'Pflugers Archiv : European Journal of Physiology'
publication_identifier:
issn:
- 0031-6768
publication_status: published
publisher: Springer
publist_id: '2890'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Patch-clamp recording in brain slices with improved slicer technology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 443
year: '2002'
...
---
_id: '3508'
abstract:
- lang: eng
text: A method of automatic conversion of a physical object into a three-dimensional
digital model. The method acquires a set of measured data points on the surface
of a physical model. From the measured data points, the method reconstructs a
digital model of the physical object using a Delaunay complex of the points, a
flow strcuture of the simplicies in the Delaunay complex and retracting the Delaunay
complex into a digital model of the physical object using the flow structure.
The method then outputs the digital model of the physical object.
applicant:
- Raindrop Geomagic, Inc.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
citation:
ama: Edelsbrunner H, Fu P. Methods of generating three-dimensional digital models
of objects by wrapping point cloud data points. 2002.
apa: Edelsbrunner, H., & Fu, P. (2002). Methods of generating three-dimensional
digital models of objects by wrapping point cloud data points.
chicago: Edelsbrunner, Herbert, and Ping Fu. “Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points,” 2002.
ieee: H. Edelsbrunner and P. Fu, “Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.” 2002.
ista: Edelsbrunner H, Fu P. 2002. Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.
mla: Edelsbrunner, Herbert, and Ping Fu. Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points. 2002.
short: H. Edelsbrunner, P. Fu, (2002).
date_created: 2018-12-11T12:03:42Z
date_published: 2002-04-23T00:00:00Z
date_updated: 2022-01-05T14:09:36Z
day: '23'
extern: '1'
ipc: G16Z99/00 ; G06K9/28 ; G06T17/10 ; G06T17/20
ipn: US6377865B1
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US6377865B1
month: '04'
oa: 1
oa_version: Published Version
publication_date: 2002-04-23
publist_id: '2879'
status: public
title: Methods of generating three-dimensional digital models of objects by wrapping
point cloud data points
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2002'
...
---
_id: '3533'
abstract:
- lang: eng
text: 'Information in neuronal networks is thought to be represented by the rate
of discharge and the temporal relationship between the discharging neurons. The
discharge frequency of neurons is affected by their afferents and intrinsic properties,
and shows great individual variability. The temporal coordination of neurons is
greatly facilitated by network oscillations. In the hippocampus, population synchrony
fluctuates during theta and gamma oscillations (10-100 ms scale) and can increase
almost 10-fold during sharp wave bursts. Despite these large changes in excitability
in the sub-second scale, longer-term (minute-scale) firing rates of individual
neurons are relatively constant in an unchanging environment. As a result, mean
hippocampal output remains stable over time. To understand the mechanisms responsible
for this homeostasis, we address the following issues: (i) Can firing rates of
single cells be modified? (ii) Once modified, what mechanism(s) can maintain the
changes? We show that firing rates of hippocampal pyramidal cells can be altered
in a novel environment and by Hebbian pairing of physiological input patterns
with postsynaptic burst discharge. We also illustrate a competition between single
spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold)
inputs decrease the ability of strong (''teaching'') inputs to induce a burst
discharge, we propose that the single spike versus burst competition presents
a homeostatic regulatory mechanism to maintain synaptic strength and, consequently,
firing rate in pyramidal cells.'
article_processing_charge: No
article_type: original
author:
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Kenneth
full_name: Harris, Kenneth
last_name: Harris
- first_name: D.
full_name: Henze, D.
last_name: Henze
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
citation:
ama: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral
Cortex. 2002;12(9):893-899. doi:10.1093/cercor/12.9.893
apa: Buzsáki, G., Csicsvari, J. L., Dragoi, G., Harris, K., Henze, D., & Hirase,
H. (2002). Homeostatic maintenance of neuronal excitability by burst discharges
in vivo. Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.9.893
chicago: Buzsáki, György, Jozsef L Csicsvari, George Dragoi, Kenneth Harris, D.
Henze, and Hajima Hirase. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex. Oxford University Press, 2002.
https://doi.org/10.1093/cercor/12.9.893.
ieee: G. Buzsáki, J. L. Csicsvari, G. Dragoi, K. Harris, D. Henze, and H. Hirase,
“Homeostatic maintenance of neuronal excitability by burst discharges in vivo,”
Cerebral Cortex, vol. 12, no. 9. Oxford University Press, pp. 893–899,
2002.
ista: Buzsáki G, Csicsvari JL, Dragoi G, Harris K, Henze D, Hirase H. 2002. Homeostatic
maintenance of neuronal excitability by burst discharges in vivo. Cerebral Cortex.
12(9), 893–899.
mla: Buzsáki, György, et al. “Homeostatic Maintenance of Neuronal Excitability by
Burst Discharges in Vivo.” Cerebral Cortex, vol. 12, no. 9, Oxford University
Press, 2002, pp. 893–99, doi:10.1093/cercor/12.9.893.
short: G. Buzsáki, J.L. Csicsvari, G. Dragoi, K. Harris, D. Henze, H. Hirase, Cerebral
Cortex 12 (2002) 893–899.
date_created: 2018-12-11T12:03:50Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-17T07:27:12Z
day: '01'
doi: 10.1093/cercor/12.9.893
extern: '1'
external_id:
pmid:
- '12183388'
intvolume: ' 12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 893 - 899
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '2851'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Homeostatic maintenance of neuronal excitability by burst discharges in vivo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '3621'
abstract:
- lang: eng
text: In 1991, Barton and Turelli developed recursions to describe the evolution
of multilocus systems under arbitrary forms of selection. This article generalizes
their approach to allow for arbitrary modes of inheritance, including diploidy,
polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The
framework is also extended to allow for other deterministic evolutionary forces,
including migration and mutation. Exact recursions that fully describe the state
of the population are presented; these are implemented in a computer algebra package
(available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality
of our framework, it can describe evolutionary dynamics exactly by just two equations.
These recursions can be further simplified using a "quasi-linkage equilibrium"
(QLE) approximation. We illustrate the methods by finding the effect of natural
selection, sexual selection, mutation, and migration on the genetic composition
of a population.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Toby
full_name: Johnson, Toby
last_name: Johnson
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution.
Genetics. 2002;161(4):1727-1750. doi:10.1093/genetics/161.4.1727
apa: Kirkpatrick, M., Johnson, T., & Barton, N. H. (2002). General models of
multilocus evolution. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.4.1727
chicago: Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models
of Multilocus Evolution.” Genetics. Genetics Society of America, 2002.
https://doi.org/10.1093/genetics/161.4.1727.
ieee: M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus
evolution,” Genetics, vol. 161, no. 4. Genetics Society of America, pp.
1727–1750, 2002.
ista: Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution.
Genetics. 161(4), 1727–1750.
mla: Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” Genetics,
vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:10.1093/genetics/161.4.1727.
short: M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750.
date_created: 2018-12-11T12:04:17Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-11T13:20:26Z
day: '01'
doi: 10.1093/genetics/161.4.1727
extern: '1'
external_id:
pmid:
- '12196414'
intvolume: ' 161'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/
month: '08'
oa: 1
oa_version: Published Version
page: 1727 - 1750
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2762'
quality_controlled: '1'
scopus_import: '1'
status: public
title: General models of multilocus evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...
---
_id: '3757'
abstract:
- lang: eng
text: A central problem in biology is determining how genes interact as parts of
functional networks. Creation and analysis of synthetic networks, composed of
well-characterized genetic elements, provide a framework for theoretical modeling.
Here, with the use of a combinatorial method, a library of networks with varying
connectivity was generated in Escherichia coli. These networks were composed of
genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well
as the corresponding promoters. They displayed phenotypic behaviors resembling
binary logical circuits, with two chemical “inputs” and a fluorescent protein
“output.” Within this simple system, diverse computational functions arose through
changes in network connectivity. Combinatorial synthesis provides an alternative
approach for studying biological networks, as well as an efficient method for
producing diverse phenotypes in vivo.
article_processing_charge: No
article_type: original
author:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Michael
full_name: Elowitz, Michael
last_name: Elowitz
- first_name: Weihong
full_name: Hsing, Weihong
last_name: Hsing
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic
networks. Science. 2002;296(5572):1466-1470. doi:10.1126/science.1067407
apa: Guet, C. C., Elowitz, M., Hsing, W., & Leibler, S. (2002). Combinatorial
synthesis of genetic networks. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1067407
chicago: Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial
Synthesis of Genetic Networks.” Science. American Association for the Advancement
of Science, 2002. https://doi.org/10.1126/science.1067407.
ieee: C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis
of genetic networks,” Science, vol. 296, no. 5572. American Association
for the Advancement of Science, pp. 1466–1470, 2002.
ista: Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic
networks. Science. 296(5572), 1466–1470.
mla: Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” Science,
vol. 296, no. 5572, American Association for the Advancement of Science, 2002,
pp. 1466–70, doi:10.1126/science.1067407.
short: C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470.
date_created: 2018-12-11T12:05:00Z
date_published: 2002-05-24T00:00:00Z
date_updated: 2023-07-11T12:48:53Z
day: '24'
doi: 10.1126/science.1067407
extern: '1'
external_id:
pmid:
- '12029133'
intvolume: ' 296'
issue: '5572'
language:
- iso: eng
month: '05'
oa_version: None
page: 1466 - 1470
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2471'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combinatorial synthesis of genetic networks
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 296
year: '2002'
...