---
_id: '2616'
abstract:
- lang: eng
text: Neurons in the rat cerebral cortex are enriched in group I metabotropic glutamate
receptor (mGluR) subtypes and respond to their activation during development.
To understand better the mechanisms by which mGluR1 and mGluR5 mediate these effects,
the goal of this study was to elucidate the expression pattern and to determine
the cellular and the precise subcellular localization of these two receptor subtypes
in the rat neocortex and hippocampus during late prenatal and postnatal development.
At the light microscopic level, mGluR1 α and mGluR5 were first detected in the
cerebral cortex with different expression levels at embryonic day E18. Thus, mGluR5
had a moderate expression, whereas mGluR1 α was detected as a diffuse and weak
labeling. mGluR5 was localized in some Cajal-Retzius cells as well as in other
cell types, such as pioneer neurons of the marginal zone. During postnatal development,
the distribution of the receptors dramatically changed. From P0 to around P10,
mGluR1α was localized in identified, transient Cajal-Retzius cells of neocortex
and hippocampus, until these cells disappear. In addition, a population of interneurons
localized the receptor from the second/third postnatal week. In contrast, mGluR5
was localized mainly in pyramidal cells and in some interneurons, with a neuropilar
staining throughout the cerebral cortex. At the electron microscopic level, the
immunoreactivity for both group I mGluR subtypes was expressed postsynaptically.
Using immunogold methods, mGluR1α and mGluR5 immunoreactivities were found throughout
postnatal development at the edge of postsynaptic specialization of asymmetrical
synapses. These results show that the two group I mGluRs have a differential expression
pattern in neocortex and hippocampus that may suggest roles for the receptors
in the early processing of cortical information and in the control of cortical
developmental events.
acknowledgement: The authors are grateful to Dr Ole Paulsen and Professor Kay Davies
for their comments on the manuscript. We also would like to thank Dr Zoltan Molnar
for his support and Mrs Lucy Jones, Ms Courtney Voelker and Mr David Dongworth for
the English revision of the manuscript. This work was supported by grants from the
European Community (QLG3-CT-1999-00192 to R.L.) and the Spanish Ministerio de Ciencia
y Tecnología (PB97-0582-CO2-01 to A.F.).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: López Bendito G, Shigemoto R, Fairén A, Luján R. Differential distribution
of group I metabotropic glutamate receptors during rat cortical development. Cerebral
Cortex. 2002;12(6):625-638. doi:10.1093/cercor/12.6.625
apa: López Bendito, G., Shigemoto, R., Fairén, A., & Luján, R. (2002). Differential
distribution of group I metabotropic glutamate receptors during rat cortical development.
Cerebral Cortex. Oxford University Press. https://doi.org/10.1093/cercor/12.6.625
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Alfonso Fairén, and Rafael
Luján. “Differential Distribution of Group I Metabotropic Glutamate Receptors
during Rat Cortical Development.” Cerebral Cortex. Oxford University Press,
2002. https://doi.org/10.1093/cercor/12.6.625.
ieee: G. López Bendito, R. Shigemoto, A. Fairén, and R. Luján, “Differential distribution
of group I metabotropic glutamate receptors during rat cortical development,”
Cerebral Cortex, vol. 12, no. 6. Oxford University Press, pp. 625–638,
2002.
ista: López Bendito G, Shigemoto R, Fairén A, Luján R. 2002. Differential distribution
of group I metabotropic glutamate receptors during rat cortical development. Cerebral
Cortex. 12(6), 625–638.
mla: López Bendito, Guillermina, et al. “Differential Distribution of Group I Metabotropic
Glutamate Receptors during Rat Cortical Development.” Cerebral Cortex,
vol. 12, no. 6, Oxford University Press, 2002, pp. 625–38, doi:10.1093/cercor/12.6.625.
short: G. López Bendito, R. Shigemoto, A. Fairén, R. Luján, Cerebral Cortex 12 (2002)
625–638.
date_created: 2018-12-11T11:58:41Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-07-25T09:54:10Z
day: '01'
doi: 10.1093/cercor/12.6.625
extern: '1'
external_id:
pmid:
- '12003862'
intvolume: ' 12'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 625 - 638
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '4282'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential distribution of group I metabotropic glutamate receptors during
rat cortical development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2617'
abstract:
- lang: eng
text: Synapses exhibit different short-term plasticity patterns and this behaviour
influences information processing in neuronal networks. We tested how the short-term
plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic
cell type, identified by axonal arborizations and molecular markers in the hippocampal
CA1 area. Three distinct types of short-term synaptic behaviour (facilitating,
depressing and combined facilitating-depressing) were defined by fitting a dynamic
neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare
(O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells
EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive
for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a
positive axon terminals. Responses in eight of 12 basket cells were described
well with a model involving only depression, but the other cells displayed combined
facilitating-depressing EPSCs. No apparent difference was found between the plasticity
of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified
cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing,
and the remaining five cells combined facilitating-depressing EPSCs. Seven of
10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable
only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the
CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic
responses to action potentials recorded in vivo from a CA1 place cell were modelled,
and revealed great differences between and within cell types. Our results demonstrate
that the short-term plasticity of EPSCs is cell type dependent, but with significant
heterogeneity within all three interneurone populations.
author:
- first_name: Attila
full_name: Losonczy, Attila
last_name: Losonczy
- first_name: Limei
full_name: Zhang, Limei
last_name: Zhang
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
citation:
ama: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence
and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
interneurones. Journal of Physiology. 2002;542(1):193-210. doi:10.1113/jphysiol.2002.020024
apa: Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., & Nusser, Z. (2002).
Cell type dependence and variability in the short-term plasticity of EPSCs in
identified mouse hippocampal interneurones. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2002.020024
chicago: Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán
Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of
EPSCs in Identified Mouse Hippocampal Interneurones.” Journal of Physiology.
Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2002.020024.
ieee: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type
dependence and variability in the short-term plasticity of EPSCs in identified
mouse hippocampal interneurones,” Journal of Physiology, vol. 542, no.
1. Wiley-Blackwell, pp. 193–210, 2002.
ista: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence
and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
interneurones. Journal of Physiology. 542(1), 193–210.
mla: Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term
Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” Journal
of Physiology, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:10.1113/jphysiol.2002.020024.
short: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology
542 (2002) 193–210.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2021-01-12T06:58:36Z
day: '01'
doi: 10.1113/jphysiol.2002.020024
extern: 1
intvolume: ' 542'
issue: '1'
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/
month: '07'
oa: 1
page: 193 - 210
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4281'
quality_controlled: 0
status: public
title: Cell type dependence and variability in the short-term plasticity of EPSCs
in identified mouse hippocampal interneurones
type: journal_article
volume: 542
year: '2002'
...
---
_id: '2618'
abstract:
- lang: eng
text: The unipolar brush cell (UBC) is a type of glutamatergic interneuron in the
granular layer of the cerebellum. The UBC brush and a single mossy fiber (MF)
terminal contact each other within a cerebellar glomerulus, forming a giant synapse.
Many UBCs receive input from extrinsic MFs, whereas others are innervated by intrinsic
mossy terminals formed by the axons of other UBCs. In all mammalian species so
far examined, the vestibulocerebellum is enriched of UBCs that are strongly immunoreactive
for the calcium binding protein calretinin (CR) in both the somatodendritic and
axonal compartment. UBCs have postsynaptic ionotropic glutamate receptors and
extrasynaptic metabotropic glutamate receptors that immunocytochemically highlight
their somatodendritic compartment and brush, respectively. In this study on the
mouse cerebellum, we present evidence that immunoreactivities to CR and mGluR1α
define two distinct UBC subsets with partly overlapping distributions in lobule
X (the nodulus). In sections double-labeled for CR and mGluR1α, the patterns of
distributions of CR+/mGluR1α- UBCs and CR-/mGluR1α+ UBCs differed along the mediolateral
and dorsoventral axes of the folium. Moreover, mGluR1α+ UBCs outnumbered CR+ UBCs.
Both UBC subsets were mGluR2/3, GluR2/3, and NMDAR1 immunoreactive. The different
distribution patterns of the two UBC subsets within lobule X suggest that expression
of CR or mGluR1α by UBCs may be afferent-specific and related to the terminal
fields of different vestibular MF afferents.
article_processing_charge: No
article_type: original
author:
- first_name: Maria
full_name: Nunzi, Maria
last_name: Nunzi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Enrico
full_name: Mugnaini, Enrico
last_name: Mugnaini
citation:
ama: Nunzi M, Shigemoto R, Mugnaini E. Differential expression of calretinin and
metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush cells
in mouse cerebellum. Journal of Comparative Neurology. 2002;451(2):189-199.
doi:10.1002/cne.10344
apa: Nunzi, M., Shigemoto, R., & Mugnaini, E. (2002). Differential expression
of calretinin and metabotropic glutamate receptor mGluR1α defines subsets of unipolar
brush cells in mouse cerebellum. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.10344
chicago: Nunzi, Maria, Ryuichi Shigemoto, and Enrico Mugnaini. “Differential Expression
of Calretinin and Metabotropic Glutamate Receptor MGluR1α Defines Subsets of Unipolar
Brush Cells in Mouse Cerebellum.” Journal of Comparative Neurology. Wiley-Blackwell,
2002. https://doi.org/10.1002/cne.10344.
ieee: M. Nunzi, R. Shigemoto, and E. Mugnaini, “Differential expression of calretinin
and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush
cells in mouse cerebellum,” Journal of Comparative Neurology, vol. 451,
no. 2. Wiley-Blackwell, pp. 189–199, 2002.
ista: Nunzi M, Shigemoto R, Mugnaini E. 2002. Differential expression of calretinin
and metabotropic glutamate receptor mGluR1α defines subsets of unipolar brush
cells in mouse cerebellum. Journal of Comparative Neurology. 451(2), 189–199.
mla: Nunzi, Maria, et al. “Differential Expression of Calretinin and Metabotropic
Glutamate Receptor MGluR1α Defines Subsets of Unipolar Brush Cells in Mouse Cerebellum.”
Journal of Comparative Neurology, vol. 451, no. 2, Wiley-Blackwell, 2002,
pp. 189–99, doi:10.1002/cne.10344.
short: M. Nunzi, R. Shigemoto, E. Mugnaini, Journal of Comparative Neurology 451
(2002) 189–199.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-09-16T00:00:00Z
date_updated: 2023-07-25T09:09:48Z
day: '16'
doi: 10.1002/cne.10344
extern: '1'
external_id:
pmid:
- '12209836'
intvolume: ' 451'
issue: '2'
language:
- iso: eng
month: '09'
oa_version: None
page: 189 - 199
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4279'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential expression of calretinin and metabotropic glutamate receptor mGluR1α
defines subsets of unipolar brush cells in mouse cerebellum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 451
year: '2002'
...
---
_id: '2619'
abstract:
- lang: eng
text: The release of glutamate and GABA is modulated by presynaptic metabotropic
glutamate receptors (mGluRs). We used immunocytochemical methods to define the
location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals
innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a
was localized in the presynaptic active zone of both identified GABAergic and
presumed glutamatergic terminals. Terminals innervating dendritic spines showed
a variable level of receptor immunoreactivity, ranging from immunonegative to
strongly immunopositive. The frequency of strongly mGluR7a positive terminals
innervating the soma and dendrites of mGluR1α/somatostatin-expressing interneurons
was very high relative to other neurons. On dendrites that received mGluR7a-enriched
glutamatergic innervation, at least 80% of GABAergic terminals were immunopositive
for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide
(VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of
VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons,
which were mostly somatostatin immunopositive. Parvalbumin positive terminals
were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received
strongly mGluR7a positive terminals. The subcellular location, as well as the
cell type and synapse-specific distribution of mGluR7a in isocortical neuronal
circuits, is homologous to its distribution in the hippocampus. The specific location
of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic
synapses may be related to the proximity of calcium channels and the vesicle fusion
machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the
glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests
that their activation is under unique regulation by extracellular glutamate.
acknowledgement: We thank Dr C. Paspalas for an initial contribution to the immunocytochemistry.
We are grateful for the generous gifts of antibodies from Dr A. Buchan (anti-somatostatin,
Department of Physiology, University of British Columbia, Canada), Dr M. Watanabe
(anti-mGluR1α, Department of Anatomy, Hokkaido University School of Medicine, Sapporo)
and Dr K. Tanaka (anti-GAD, Niigata University, Faculty of Medicine, Department
of Neurology). We thank Dr F. Ferraguti for helpful suggestions during the project
and for his comments on a previous version of the manuscript. We also thank Philip
Cobden, Paul Jays and Laszlo Marton for assistance. Y.D. was supported by a Wellcome
Trust Advanced Training Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Yannis
full_name: Dalezios, Yannis
last_name: Dalezios
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: John
full_name: Roberts, John
last_name: Roberts
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a
in the Presynaptic active zones of GABAergic and Non-GABAergic terminals on interneurons
in the rat somatosensory cortex. Cerebral Cortex. 2002;12(9):961-974. doi:10.1093/cercor/12.9.961
apa: Dalezios, Y., Luján, R., Shigemoto, R., Roberts, J., & Somogyi, P. (2002).
Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic
terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex.
Oxford University Press. https://doi.org/10.1093/cercor/12.9.961
chicago: Dalezios, Yannis, Rafael Luján, Ryuichi Shigemoto, John Roberts, and Péter
Somogyi. “Enrichment of MGluR7a in the Presynaptic Active Zones of GABAergic and
Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex.” Cerebral
Cortex. Oxford University Press, 2002. https://doi.org/10.1093/cercor/12.9.961.
ieee: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, and P. Somogyi, “Enrichment
of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals
on interneurons in the rat somatosensory cortex,” Cerebral Cortex, vol.
12, no. 9. Oxford University Press, pp. 961–974, 2002.
ista: Dalezios Y, Luján R, Shigemoto R, Roberts J, Somogyi P. 2002. Enrichment of
mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic terminals
on interneurons in the rat somatosensory cortex. Cerebral Cortex. 12(9), 961–974.
mla: Dalezios, Yannis, et al. “Enrichment of MGluR7a in the Presynaptic Active Zones
of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory
Cortex.” Cerebral Cortex, vol. 12, no. 9, Oxford University Press, 2002,
pp. 961–74, doi:10.1093/cercor/12.9.961.
short: Y. Dalezios, R. Luján, R. Shigemoto, J. Roberts, P. Somogyi, Cerebral Cortex
12 (2002) 961–974.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-25T09:40:49Z
day: '01'
doi: 10.1093/cercor/12.9.961
extern: '1'
external_id:
pmid:
- '12183395'
intvolume: ' 12'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 961 - 974
pmid: 1
publication: Cerebral Cortex
publication_identifier:
issn:
- 1047-3211
publication_status: published
publisher: Oxford University Press
publist_id: '4280'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Enrichment of mGluR7a in the Presynaptic active zones of GABAergic and Non-GABAergic
terminals on interneurons in the rat somatosensory cortex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2620'
abstract:
- lang: eng
text: An ion channel's function depends largely on its location and density on neurons.
Here we used high-resolution immunolocalization to determine the subcellular distribution
of the hyperpolarization-activated and cyclic-nucleotide-gated channel subunit
1 (HCN1) in rat brain. Light microscopy revealed graded HCN1 immunoreactivity
in apical dendrites of hippocampal, subicular and neocortical layer-5 pyramidal
cells. Quantitative comparison of immunogold densities showed a 60-fold increase
from somatic to distal apical dendritic membranes. Distal dendritic shafts had
16 times more HCN1 labeling than proximal dendrites of similar diameters. At the
same distance from the soma, the density of HCN1 was significantly higher in dendritic
shafts than in spines. Our results reveal the complex cell surface distribution
of voltage-gated ion-channels, and predict its role in increasing the computational
power of single neurons via subcellular domain and input-specific mechanisms.
acknowledgement: Z.N. received grants from the Hungarian Science Foundation (T032309),
the Howard Hughes Medical Institute, the James S. McDonnell Foundation, the Wellcome
Trust and the Boehringer Ingelheim Fund. Z.N. and R.S. received grants from CREST—Japan
Science and Technology Corporation. G.T. is funded by the Wellcome Trust.
article_processing_charge: No
article_type: original
author:
- first_name: Andrea
full_name: Lörincz, Andrea
last_name: Lörincz
- first_name: Takuya
full_name: Notomi, Takuya
last_name: Notomi
- first_name: Gábor
full_name: Tamás, Gábor
last_name: Tamás
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Zoltán
full_name: Nusser, Zoltán
last_name: Nusser
citation:
ama: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. Polarized and compartment-dependent
distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience.
2002;5(11):1185-1193. doi:10.1038/nn962
apa: Lörincz, A., Notomi, T., Tamás, G., Shigemoto, R., & Nusser, Z. (2002).
Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn962
chicago: Lörincz, Andrea, Takuya Notomi, Gábor Tamás, Ryuichi Shigemoto, and Zoltán
Nusser. “Polarized and Compartment-Dependent Distribution of HCN1 in Pyramidal
Cell Dendrites.” Nature Neuroscience. Nature Publishing Group, 2002. https://doi.org/10.1038/nn962.
ieee: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, and Z. Nusser, “Polarized and
compartment-dependent distribution of HCN1 in pyramidal cell dendrites,” Nature
Neuroscience, vol. 5, no. 11. Nature Publishing Group, pp. 1185–1193, 2002.
ista: Lörincz A, Notomi T, Tamás G, Shigemoto R, Nusser Z. 2002. Polarized and compartment-dependent
distribution of HCN1 in pyramidal cell dendrites. Nature Neuroscience. 5(11),
1185–1193.
mla: Lörincz, Andrea, et al. “Polarized and Compartment-Dependent Distribution of
HCN1 in Pyramidal Cell Dendrites.” Nature Neuroscience, vol. 5, no. 11,
Nature Publishing Group, 2002, pp. 1185–93, doi:10.1038/nn962.
short: A. Lörincz, T. Notomi, G. Tamás, R. Shigemoto, Z. Nusser, Nature Neuroscience
5 (2002) 1185–1193.
date_created: 2018-12-11T11:58:43Z
date_published: 2002-11-01T00:00:00Z
date_updated: 2023-07-25T09:02:48Z
day: '01'
doi: 10.1038/nn962
extern: '1'
external_id:
pmid:
- '12389030'
intvolume: ' 5'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1185 - 1193
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
publication_status: published
publisher: Nature Publishing Group
publist_id: '4278'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polarized and compartment-dependent distribution of HCN1 in pyramidal cell
dendrites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '2002'
...
---
_id: '2621'
abstract:
- lang: eng
text: The release properties of glutamatergic nerve terminals are influenced by
a number of factors, including the subtype of voltage-dependent calcium channel
and the presence of presynaptic autoreceptors. Group III metabotropic glutamate
receptors (mGluRs) mediate feedback inhibition of glutamate release by inhibiting
Ca2+ channel activity. By imaging Ca2+ in preparations of cerebrocortical nerve
terminals, we show that voltage-dependent Ca2+ channels are distributed in a heterogeneous
manner in individual nerve terminals. Presynaptic terminals contained only N-type
(47.5%; conotoxin GVIA-sensitive), P/Q-type (3.9%; agatoxin IVA-sensitive), or
both N- and P/Q-type (42.6%) Ca2+ channels, although the remainder of the terminals
(6.1%) were insensitive to these two toxins. In this preparation, two mGluRs with
high and low affinity for L(+)-2-amino-4-phosphonobutyrate were identified by
immunocytochemistry as mGluR4 and mGluR7, respectively. These receptors were responsible
for 22.2 and 24.1% reduction of glutamate release, and they reduced the Ca2+ response
in 24.4 and 30.3% of the nerve terminals, respectively. Interestingly, mGluR4
was largely (73.7%) located in nerve terminals expressing both N- and P/Q-type
Ca2+ channels, whereas mGluR7 was predominantly (69.9%) located in N-type Ca2+
channel-expressing terminals. This specific coexpression of different group III
mGluRs and Ca2+ channels may endow synaptic terminals with distinct release properties
and reveals the existence of a high degree of presynaptic heterogeneity.
acknowledgement: We thank M. Sefton for editorial assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Carmelo
full_name: Millán, Carmelo
last_name: Millán
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: José
full_name: Sánchez Prieto, José
last_name: Sánchez Prieto
citation:
ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. Subtype-specific expression
of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve
terminals. Journal of Biological Chemistry. 2002;277(49):47796-47803. doi:10.1074/jbc.M207531200
apa: Millán, C., Luján, R., Shigemoto, R., & Sánchez Prieto, J. (2002). Subtype-specific
expression of Group III metabotropic glutamate receptors and Ca2+ channels in
single nerve terminals. Journal of Biological Chemistry. American Society
for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M207531200
chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto.
“Subtype-Specific Expression of Group III Metabotropic Glutamate Receptors and
Ca2+ Channels in Single Nerve Terminals.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2002. https://doi.org/10.1074/jbc.M207531200.
ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “Subtype-specific
expression of Group III metabotropic glutamate receptors and Ca2+ channels in
single nerve terminals,” Journal of Biological Chemistry, vol. 277, no.
49. American Society for Biochemistry and Molecular Biology, pp. 47796–47803,
2002.
ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. Subtype-specific expression
of Group III metabotropic glutamate receptors and Ca2+ channels in single nerve
terminals. Journal of Biological Chemistry. 277(49), 47796–47803.
mla: Millán, Carmelo, et al. “Subtype-Specific Expression of Group III Metabotropic
Glutamate Receptors and Ca2+ Channels in Single Nerve Terminals.” Journal of
Biological Chemistry, vol. 277, no. 49, American Society for Biochemistry
and Molecular Biology, 2002, pp. 47796–803, doi:10.1074/jbc.M207531200.
short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological
Chemistry 277 (2002) 47796–47803.
date_created: 2018-12-11T11:58:43Z
date_published: 2002-12-02T00:00:00Z
date_updated: 2023-07-19T07:49:19Z
day: '02'
doi: 10.1074/jbc.M207531200
extern: '1'
external_id:
pmid:
- '12376542'
intvolume: ' 277'
issue: '49'
language:
- iso: eng
month: '12'
oa_version: Published Version
page: 47796 - 47803
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4277'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Subtype-specific expression of Group III metabotropic glutamate receptors and
Ca2+ channels in single nerve terminals
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 277
year: '2002'
...
---
_id: '2622'
abstract:
- lang: eng
text: To understand the possible contribution of metabotropic γ-aminobutyric acid
receptors (GABABR) in cortical development, we investigated the expression pattern
and the cellular and subcellular localization of the GABABR1 and GABABR2 subtypes
in the rat neocortex from embryonic day 14 (E14) to adulthood. At the light microscopic
level, both GABABR1 and GABABR2 were detected as early as E14. During prenatal
development, both subtypes were expressed highly in the cortical plate. Using
double immunofluorescence, GABABR1 colocalized with GABABR2 in neurons of the
marginal zone and subplate, indicating that these proteins are coexpressed and
could be forming functional GABABRs during prenatal development in vivo. In contrast,
only GABABR1 but not GABABR2 was detected in the tangentially migratory cells
in the lower intermediate zone. During postnatal development, immunoreactivity
for GABABR1 and GABABR2 was distributed mainly in pyramidal cells. Discrete GABABR1-immunopositive
cell bodies of interneurons were present throughout the neocortex. In addition,
GABABR1 but not GABABR2 was found in identified Cajal-Retzius cells in layer I.
At the electron microscopic level, immunoreactivity for GABABR1 and GABABR2 was
found in dendritic spines and dendritic shafts at extrasynaptic and perisynaptic
sites throughout postnatal development. We further demonstrated the presynaptic
localization of GABABR1 and GABABR2, as well as the association of the receptors
with asymmetrical synaptic junctions. These results indicate potentially important
roles for the GABABRs in the regulation of migratory processes during corticogenesis
and in the modulation of synaptic transmission during early development of cortical
circuitry.
acknowledgement: The authors are grateful to Dr Marco Sassoe-Pogneto for his comments
on a previous version of the manuscript. We also would like to thank to Ms. Courtney
Voelker for the English revision and comments of the manuscript. This work was made
possible by grants from the European Community (QLG3-CT-1999–00192, R.L) and the
Spanish Ministry of Science and Technology (PB97-0582-CO2-01, A.F).
article_processing_charge: No
article_type: original
author:
- first_name: Guillermina
full_name: López Bendito, Guillermina
last_name: López Bendito
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Ole
full_name: Paulsen, Ole
last_name: Paulsen
- first_name: Alfonso
full_name: Fairén, Alfonso
last_name: Fairén
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. Expression
and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during
rat neocortical development. European Journal of Neuroscience. 2002;15(11):1766-1778.
doi:10.1046/j.1460-9568.2002.02032.x
apa: López Bendito, G., Shigemoto, R., Kulik, Á., Paulsen, O., Fairén, A., &
Luján, R. (2002). Expression and distribution of metabotropic GABA receptor subtypes
GABABR1 and GABABR2 during rat neocortical development. European Journal of
Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.2002.02032.x
chicago: López Bendito, Guillermina, Ryuichi Shigemoto, Ákos Kulik, Ole Paulsen,
Alfonso Fairén, and Rafael Luján. “Expression and Distribution of Metabotropic
GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.”
European Journal of Neuroscience. Wiley-Blackwell, 2002. https://doi.org/10.1046/j.1460-9568.2002.02032.x.
ieee: G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, and R. Luján,
“Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and
GABABR2 during rat neocortical development,” European Journal of Neuroscience,
vol. 15, no. 11. Wiley-Blackwell, pp. 1766–1778, 2002.
ista: López Bendito G, Shigemoto R, Kulik Á, Paulsen O, Fairén A, Luján R. 2002.
Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and
GABABR2 during rat neocortical development. European Journal of Neuroscience.
15(11), 1766–1778.
mla: López Bendito, Guillermina, et al. “Expression and Distribution of Metabotropic
GABA Receptor Subtypes GABABR1 and GABABR2 during Rat Neocortical Development.”
European Journal of Neuroscience, vol. 15, no. 11, Wiley-Blackwell, 2002,
pp. 1766–78, doi:10.1046/j.1460-9568.2002.02032.x.
short: G. López Bendito, R. Shigemoto, Á. Kulik, O. Paulsen, A. Fairén, R. Luján,
European Journal of Neuroscience 15 (2002) 1766–1778.
date_created: 2018-12-11T11:58:43Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-07-19T07:30:39Z
day: '01'
doi: 10.1046/j.1460-9568.2002.02032.x
extern: '1'
external_id:
pmid:
- '12081656'
intvolume: ' 15'
issue: '11'
language:
- iso: eng
month: '06'
oa_version: None
page: 1766 - 1778
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4276'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression and distribution of metabotropic GABA receptor subtypes GABABR1
and GABABR2 during rat neocortical development
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2002'
...
---
_id: '2624'
abstract:
- lang: eng
text: Metabotropic γ-aminobutyric acid receptors (GABABRs) are involved in modulation
of synaptic transmission and activity of cerebellar and thalamic neurons. We used
subtype-specific antibodies in pre- and postembedding immunohistochemistry combined
with three-dimensional reconstruction of labelled profiles and quantification
of immunoparticles to reveal the subcellular distribution of pre- and postsynaptic
GABABR1a/b and GABABR2 in the rat cerebellum and ventrobasal thalamus. GABABR1a/b
and R2 were extensively colocalized in most brain regions including the cerebellum
and thalamus. In the cerebellum, immunoreactivity for both subtypes was prevalent
in the molecular layer. The most intense immunoreactivity was found in Purkinje
cell spines with a high density of immunoparticles at extrasynaptic sites peaking
at around 240 nm from glutamatergic synapses between spines and parallel fibre
varicosities. This is in contrast to dendrites at sites around GABAergic synapses
where sparse and random distribution was found for both subtypes. In addition,
more than one-tenth of the synaptic membrane specialization of spine-parallel
fibre synapses were labelled at pre- or postsynaptic sites. Weak immunolabelling
for both subtypes was also seen in parallel fibres but only rarely in GABAergic
axons. In the ventrobasal thalamus, immunolabelling for both receptor subtypes
was intense over the dendritic field of thalamocortical cells. Electron microscopy
demonstrated an extrasynaptic localization of GABABR1a/b and R2 exclusively in
postsynaptic elements. Quantitative analysis further revealed the density of GABABR1a/b
around GABAergic synapses was higher than glutamatergic synapses on thalamocortical
cell dendrites. The distinct localization of GABABRs relative to synaptic sites
in the cerebellum and ventrobasal thalamus suggests that GABABRs differentially
regulate activity of different neuronal populations.
acknowledgement: This work was supported by research grants from the Ministry of Education,
Science, Sports and Culture of Japan, and the Japan Society for the Promotion of
Science (P96319). We thank Drs L. Zaborszky and R. Luján for their comments on the
manuscript, Dr M. Watanabe for kindly supplying us with GluRδ2 and AMPA GluR1 antibodies,
Dr R.E. Edwards for rabbit BNPI antibody, and J. Hatakeyama and S. Doi for technical
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Kazuhiko
full_name: Nakadate, Kazuhiko
last_name: Nakadate
- first_name: Gábor
full_name: Nyíri, Gábor
last_name: Nyíri
- first_name: Takuya
full_name: Notomi, Takuya
last_name: Notomi
- first_name: Barbara
full_name: Malitschek, Barbara
last_name: Malitschek
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Kulik Á, Nakadate K, Nyíri G, et al. Distinct localization of GABAB receptors
relative to synaptic sites in the rat cerebellum and ventrobasal thalamus. European
Journal of Neuroscience. 2002;15(2):291-307. doi:10.1046/j.0953-816x.2001.01855.x
apa: Kulik, Á., Nakadate, K., Nyíri, G., Notomi, T., Malitschek, B., Bettler, B.,
& Shigemoto, R. (2002). Distinct localization of GABAB receptors relative
to synaptic sites in the rat cerebellum and ventrobasal thalamus. European
Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.0953-816x.2001.01855.x
chicago: Kulik, Ákos, Kazuhiko Nakadate, Gábor Nyíri, Takuya Notomi, Barbara Malitschek,
Bernhard Bettler, and Ryuichi Shigemoto. “Distinct Localization of GABAB Receptors
Relative to Synaptic Sites in the Rat Cerebellum and Ventrobasal Thalamus.” European
Journal of Neuroscience. Wiley-Blackwell, 2002. https://doi.org/10.1046/j.0953-816x.2001.01855.x.
ieee: Á. Kulik et al., “Distinct localization of GABAB receptors relative
to synaptic sites in the rat cerebellum and ventrobasal thalamus,” European
Journal of Neuroscience, vol. 15, no. 2. Wiley-Blackwell, pp. 291–307, 2002.
ista: Kulik Á, Nakadate K, Nyíri G, Notomi T, Malitschek B, Bettler B, Shigemoto
R. 2002. Distinct localization of GABAB receptors relative to synaptic sites in
the rat cerebellum and ventrobasal thalamus. European Journal of Neuroscience.
15(2), 291–307.
mla: Kulik, Ákos, et al. “Distinct Localization of GABAB Receptors Relative to Synaptic
Sites in the Rat Cerebellum and Ventrobasal Thalamus.” European Journal of
Neuroscience, vol. 15, no. 2, Wiley-Blackwell, 2002, pp. 291–307, doi:10.1046/j.0953-816x.2001.01855.x.
short: Á. Kulik, K. Nakadate, G. Nyíri, T. Notomi, B. Malitschek, B. Bettler, R.
Shigemoto, European Journal of Neuroscience 15 (2002) 291–307.
date_created: 2018-12-11T11:58:44Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T13:08:40Z
day: '01'
doi: 10.1046/j.0953-816x.2001.01855.x
extern: '1'
external_id:
pmid:
- '11849296'
intvolume: ' 15'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 291 - 307
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4275'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct localization of GABAB receptors relative to synaptic sites in the
rat cerebellum and ventrobasal thalamus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2002'
...
---
_id: '2694'
abstract:
- lang: eng
text: We outline the status of rigorous derivations of certain classical evolution
equations as limits of Schrödinger dynamics. We explain two recent results jointly
with H.T. Yau in more details. The first one is the derivation of the linear Boltzmann
equation as the long time limit of the one-body Schrödinger equation with a random
potential. The second one is the mean field limit of high density bosons with
Coulomb interaction that leads to the nonlinear Hartree equation.
alternative_title:
- LNP
article_processing_charge: No
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Scaling limits of Schrödinger quantum mechanics. In: Dynamics
of Dissipation. Lecture Notes in Physics. Springer; 2002:487-506. doi:10.1007/3-540-46122-1_19'
apa: Erdös, L. (2002). Scaling limits of Schrödinger quantum mechanics. In Dynamics
of Dissipation (pp. 487–506). Springer. https://doi.org/10.1007/3-540-46122-1_19
chicago: Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” In Dynamics
of Dissipation, 487–506. Lecture Notes in Physics. Springer, 2002. https://doi.org/10.1007/3-540-46122-1_19.
ieee: L. Erdös, “Scaling limits of Schrödinger quantum mechanics,” in Dynamics
of Dissipation, Springer, 2002, pp. 487–506.
ista: 'Erdös L. 2002.Scaling limits of Schrödinger quantum mechanics. In: Dynamics
of Dissipation. LNP, , 487–506.'
mla: Erdös, László. “Scaling Limits of Schrödinger Quantum Mechanics.” Dynamics
of Dissipation, Springer, 2002, pp. 487–506, doi:10.1007/3-540-46122-1_19.
short: L. Erdös, in:, Dynamics of Dissipation, Springer, 2002, pp. 487–506.
conference:
name: '38th Winter School of Theoretical Physics : Dynamical Semigroups: Dissipation,
Chaos, Quanta'
date_created: 2018-12-11T11:59:06Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T10:23:18Z
day: '01'
doi: 10.1007/3-540-46122-1_19
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 487 - 506
publication: Dynamics of Dissipation
publication_identifier:
isbn:
- '9783540441113'
publication_status: published
publisher: Springer
publist_id: '4203'
quality_controlled: '1'
series_title: Lecture Notes in Physics
status: public
title: Scaling limits of Schrödinger quantum mechanics
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2708'
alternative_title:
- Contemporary Mathematics
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: 'Erdös L. Two dimensional Pauli operator via scalar potential. In: Vol 307.
World Scientific Publishing; 2002:129-133. doi:10.1090/conm/307'
apa: 'Erdös, L. (2002). Two dimensional Pauli operator via scalar potential (Vol.
307, pp. 129–133). Presented at the QMath: Mathematical Results in Quantum Physics,
World Scientific Publishing. https://doi.org/10.1090/conm/307'
chicago: Erdös, László. “Two Dimensional Pauli Operator via Scalar Potential,” 307:129–33.
World Scientific Publishing, 2002. https://doi.org/10.1090/conm/307.
ieee: 'L. Erdös, “Two dimensional Pauli operator via scalar potential,” presented
at the QMath: Mathematical Results in Quantum Physics, 2002, vol. 307, pp. 129–133.'
ista: 'Erdös L. 2002. Two dimensional Pauli operator via scalar potential. QMath:
Mathematical Results in Quantum Physics, Contemporary Mathematics, vol. 307, 129–133.'
mla: Erdös, László. Two Dimensional Pauli Operator via Scalar Potential.
Vol. 307, World Scientific Publishing, 2002, pp. 129–33, doi:10.1090/conm/307.
short: L. Erdös, in:, World Scientific Publishing, 2002, pp. 129–133.
conference:
name: 'QMath: Mathematical Results in Quantum Physics'
date_created: 2018-12-11T11:59:11Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:11Z
day: '01'
doi: 10.1090/conm/307
extern: 1
intvolume: ' 307'
month: '01'
page: 129 - 133
publication_status: published
publisher: World Scientific Publishing
publist_id: '4188'
quality_controlled: 0
status: public
title: Two dimensional Pauli operator via scalar potential
type: conference
volume: 307
year: '2002'
...
---
_id: '2737'
abstract:
- lang: eng
text: We derive the time-dependent Schrödinger–Poisson equation as the weak coupling
limit of the N-body linear Schrödinger equation with Coulomb potential.
acknowledgement: "The authors thank the ESI in Vienna and the Austrian START project
“Nonlinear Schrödinger\r\nand quantum Boltzmann equations” of N.J.M. for hospitality
and support. Also, F.G. was supported by the Institut\r\nUniversitaire de France
and N.J.M. by the bilateral Austrian-French “AMADEUS” programme. H.-T.Y. and L.E.
were\r\nsupported by NSF Grants DMS-0072098 and DMS-9970323, respectively"
article_processing_charge: No
article_type: original
author:
- first_name: Claude
full_name: Bardos, Claude
last_name: Bardos
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: François
full_name: Golse, François
last_name: Golse
- first_name: Norbert
full_name: Mauser, Norbert
last_name: Mauser
- first_name: Horng
full_name: Yau, Horng
last_name: Yau
citation:
ama: Bardos C, Erdös L, Golse F, Mauser N, Yau H. Derivation of the Schrödinger-Poisson
equation from the quantum N-body problem. Comptes Rendus Mathematique.
2002;334(6):515-520. doi:10.1016/S1631-073X(02)02253-7
apa: Bardos, C., Erdös, L., Golse, F., Mauser, N., & Yau, H. (2002). Derivation
of the Schrödinger-Poisson equation from the quantum N-body problem. Comptes
Rendus Mathematique. Elsevier. https://doi.org/10.1016/S1631-073X(02)02253-7
chicago: Bardos, Claude, László Erdös, François Golse, Norbert Mauser, and Horng
Yau. “Derivation of the Schrödinger-Poisson Equation from the Quantum N-Body Problem.”
Comptes Rendus Mathematique. Elsevier, 2002. https://doi.org/10.1016/S1631-073X(02)02253-7.
ieee: C. Bardos, L. Erdös, F. Golse, N. Mauser, and H. Yau, “Derivation of the Schrödinger-Poisson
equation from the quantum N-body problem,” Comptes Rendus Mathematique,
vol. 334, no. 6. Elsevier, pp. 515–520, 2002.
ista: Bardos C, Erdös L, Golse F, Mauser N, Yau H. 2002. Derivation of the Schrödinger-Poisson
equation from the quantum N-body problem. Comptes Rendus Mathematique. 334(6),
515–520.
mla: Bardos, Claude, et al. “Derivation of the Schrödinger-Poisson Equation from
the Quantum N-Body Problem.” Comptes Rendus Mathematique, vol. 334, no.
6, Elsevier, 2002, pp. 515–20, doi:10.1016/S1631-073X(02)02253-7.
short: C. Bardos, L. Erdös, F. Golse, N. Mauser, H. Yau, Comptes Rendus Mathematique
334 (2002) 515–520.
date_created: 2018-12-11T11:59:20Z
date_published: 2002-03-30T00:00:00Z
date_updated: 2023-07-18T09:24:24Z
day: '30'
doi: 10.1016/S1631-073X(02)02253-7
extern: '1'
intvolume: ' 334'
issue: '6'
language:
- iso: eng
month: '03'
oa_version: None
page: 515 - 520
publication: Comptes Rendus Mathematique
publication_identifier:
issn:
- 1631-073X
publication_status: published
publisher: Elsevier
publist_id: '4155'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Derivation of the Schrödinger-Poisson equation from the quantum N-body problem
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 334
year: '2002'
...
---
_id: '2738'
abstract:
- lang: eng
text: We consider the long time evolution of a quantum particle weakly interacting
with a phonon field. We show that in the weak coupling limit the Wigner distribution
of the electron density matrix converges to the solution of the linear Boltzmann
equation globally in time. The collision kernel is identified as the sum of an
emission and an absorption term that depend on the equilibrium distribution of
the free phonon modes.
acknowledgement: "This work initially was a joint project with H.-T. Yau and several
ideas\r\npresented here have been developed in collaboration with him. I would like\r\nto
thank him for the invaluable discussions and encouragement through\r\nthe entire
work. Part of this project was completed during several visits at\r\nthe Erwin Schrödinger
Institute, Vienna, and at the Center of Theoretical\r\nStudies, Hsinchu, Taiwan.
The author is grateful for the hospitality and\r\nfinancial support. This work was
partially supported by NSF Grant DMS9970323."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Linear Boltzmann equation as the long time dynamics of an electron
weakly coupled to a phonon field. Journal of Statistical Physics. 2002;107(5-6):1043-1127.
doi:10.1023/A:1015157624384
apa: Erdös, L. (2002). Linear Boltzmann equation as the long time dynamics of an
electron weakly coupled to a phonon field. Journal of Statistical Physics.
Springer. https://doi.org/10.1023/A:1015157624384
chicago: Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of
an Electron Weakly Coupled to a Phonon Field.” Journal of Statistical Physics.
Springer, 2002. https://doi.org/10.1023/A:1015157624384.
ieee: L. Erdös, “Linear Boltzmann equation as the long time dynamics of an electron
weakly coupled to a phonon field,” Journal of Statistical Physics, vol.
107, no. 5–6. Springer, pp. 1043–1127, 2002.
ista: Erdös L. 2002. Linear Boltzmann equation as the long time dynamics of an electron
weakly coupled to a phonon field. Journal of Statistical Physics. 107(5–6), 1043–1127.
mla: Erdös, László. “Linear Boltzmann Equation as the Long Time Dynamics of an Electron
Weakly Coupled to a Phonon Field.” Journal of Statistical Physics, vol.
107, no. 5–6, Springer, 2002, pp. 1043–127, doi:10.1023/A:1015157624384.
short: L. Erdös, Journal of Statistical Physics 107 (2002) 1043–1127.
date_created: 2018-12-11T11:59:20Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-07-18T09:08:45Z
day: '01'
doi: 10.1023/A:1015157624384
extern: '1'
external_id:
arxiv:
- math-ph/0108025
intvolume: ' 107'
issue: 5-6
language:
- iso: eng
month: '06'
oa_version: Submitted Version
page: 1043 - 1127
publication: Journal of Statistical Physics
publication_identifier:
issn:
- 0022-4715
publication_status: published
publisher: Springer
publist_id: '4154'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Linear Boltzmann equation as the long time dynamics of an electron weakly coupled
to a phonon field
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 107
year: '2002'
...
---
_id: '2739'
abstract:
- lang: eng
text: We define the two dimensional Pauli operator and identify its core for magnetic
fields that are regular Borel measures. The magnetic field is generated by a scalar
potential hence we bypass the usual A L 2loc condition on the vector potential,
which does not allow to consider such singular fields. We extend the Aharonov-Casher
theorem for magnetic fields that are measures with finite total variation and
we present a counterexample in case of infinite total variation. One of the key
technical tools is a weighted L 2 estimate on a singular integral operator.
acknowledgement: "This work started during the first author’s visit at the Erwin Schrödinger
Institute, Vienna.\r\nValuable discussions with T. Hoffmann-Ostenhof and M. Loss
are gratefully acknowledged. The authors thank\r\nthe referee for careful reading
and comments"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Vitali
full_name: Vougalter, Vitali
last_name: Vougalter
citation:
ama: Erdös L, Vougalter V. Pauli operator and Aharonov–Casher theorem¶ for measure
valued magnetic fields. Communications in Mathematical Physics. 2002;225(2):399-421.
doi:10.1007/s002200100585
apa: Erdös, L., & Vougalter, V. (2002). Pauli operator and Aharonov–Casher theorem¶
for measure valued magnetic fields. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s002200100585
chicago: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher
Theorem¶ for Measure Valued Magnetic Fields.” Communications in Mathematical
Physics. Springer, 2002. https://doi.org/10.1007/s002200100585.
ieee: L. Erdös and V. Vougalter, “Pauli operator and Aharonov–Casher theorem¶ for
measure valued magnetic fields,” Communications in Mathematical Physics,
vol. 225, no. 2. Springer, pp. 399–421, 2002.
ista: Erdös L, Vougalter V. 2002. Pauli operator and Aharonov–Casher theorem¶ for
measure valued magnetic fields. Communications in Mathematical Physics. 225(2),
399–421.
mla: Erdös, László, and Vitali Vougalter. “Pauli Operator and Aharonov–Casher Theorem¶
for Measure Valued Magnetic Fields.” Communications in Mathematical Physics,
vol. 225, no. 2, Springer, 2002, pp. 399–421, doi:10.1007/s002200100585.
short: L. Erdös, V. Vougalter, Communications in Mathematical Physics 225 (2002)
399–421.
date_created: 2018-12-11T11:59:21Z
date_published: 2002-02-01T00:00:00Z
date_updated: 2023-07-18T08:57:54Z
day: '01'
doi: 10.1007/s002200100585
extern: '1'
external_id:
arxiv:
- math-ph/0109015v1
intvolume: ' 225'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 399 - 421
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4153'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pauli operator and Aharonov–Casher theorem¶ for measure valued magnetic fields
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 225
year: '2002'
...
---
_id: '2740'
abstract:
- lang: eng
text: We show that the lowest eigenvalue of the magnetic Schrödinger operator on
a line bundle over a compact Riemann surface M is bounded by the L1-norm of the
magnetic field B. This implies a similar bound on the multiplicity of the ground
state. An example shows that this degeneracy can indeed be comparable with ∫M
|B| even in case of the trivial bundle.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Spectral shift and multiplicity of the first eigenvalue of the magnetic
Schrödinger operator in two dimensions. Annales de l’Institut Fourier.
2002;52(6):1833-1874. doi:10.5802/aif.1936
apa: Erdös, L. (2002). Spectral shift and multiplicity of the first eigenvalue of
the magnetic Schrödinger operator in two dimensions. Annales de l’Institut
Fourier. Association des Annales de l’Institut Fourier. https://doi.org/10.5802/aif.1936
chicago: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue
of the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut
Fourier. Association des Annales de l’Institut Fourier, 2002. https://doi.org/10.5802/aif.1936.
ieee: L. Erdös, “Spectral shift and multiplicity of the first eigenvalue of the
magnetic Schrödinger operator in two dimensions,” Annales de l’Institut Fourier,
vol. 52, no. 6. Association des Annales de l’Institut Fourier, pp. 1833–1874,
2002.
ista: Erdös L. 2002. Spectral shift and multiplicity of the first eigenvalue of
the magnetic Schrödinger operator in two dimensions. Annales de l’Institut Fourier.
52(6), 1833–1874.
mla: Erdös, László. “Spectral Shift and Multiplicity of the First Eigenvalue of
the Magnetic Schrödinger Operator in Two Dimensions.” Annales de l’Institut
Fourier, vol. 52, no. 6, Association des Annales de l’Institut Fourier, 2002,
pp. 1833–74, doi:10.5802/aif.1936.
short: L. Erdös, Annales de l’Institut Fourier 52 (2002) 1833–1874.
date_created: 2018-12-11T11:59:21Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T08:38:34Z
day: '01'
doi: 10.5802/aif.1936
extern: '1'
intvolume: ' 52'
issue: '6'
language:
- iso: eng
month: '01'
oa_version: None
page: 1833-1874
publication: Annales de l'Institut Fourier
publication_identifier:
issn:
- 0373-0956
publication_status: published
publisher: Association des Annales de l'Institut Fourier
publist_id: '4152'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spectral shift and multiplicity of the first eigenvalue of the magnetic Schrödinger
operator in two dimensions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '2002'
...
---
_id: '2866'
abstract:
- lang: eng
text: 'Developmental responses to the plant hormone auxin are thought to be mediated
by interacting pairs from two protein families: short-lived inhibitory IAA proteins
and ARF transcription factors binding to auxin-response elements. Monopteros mutants
lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate
the root meristem during early embryogenesis. Here we show that the bodenlos phenotype
results from an amino-acid exchange in the conserved degradation domain of IAA12.
BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes
are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS
action in root meristem initiation.'
acknowledgement: "We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth
and J. Friml for providing clones for in situ probes; K. Harter for making available
the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer,
D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript.
This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens
bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part
by payment of page charges. This article must therefore be hereby marked “advertisement”
in accordance with 18 USC section 1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Thorsten
full_name: Hamann, Thorsten
last_name: Hamann
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Isabel
full_name: Bäurle, Isabel
last_name: Bäurle
- first_name: Marika
full_name: Kientz, Marika
last_name: Kientz
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
citation:
ama: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS
gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning.
Genes and Development. 2002;16(13):1610-1615. doi:10.1101/gad.229402
apa: Hamann, T., Benková, E., Bäurle, I., Kientz, M., & Jürgens, G. (2002).
The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.229402
chicago: Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens.
“The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated
Embryo Patterning.” Genes and Development. Cold Spring Harbor Laboratory
Press, 2002. https://doi.org/10.1101/gad.229402.
ieee: T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis
BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning,” Genes and Development, vol. 16, no. 13. Cold Spring
Harbor Laboratory Press, pp. 1610–1615, 2002.
ista: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis
BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
embryo patterning. Genes and Development. 16(13), 1610–1615.
mla: Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response
Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” Genes and Development,
vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:10.1101/gad.229402.
short: T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development
16 (2002) 1610–1615.
date_created: 2018-12-11T12:00:01Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2023-07-18T08:26:58Z
day: '01'
doi: 10.1101/gad.229402
extern: '1'
external_id:
pmid:
- '12101120'
intvolume: ' 16'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/
month: '07'
oa: 1
oa_version: Published Version
page: 1610 - 1615
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting
MONOPTEROS-mediated embryo patterning
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2002'
...
---
_id: '2927'
abstract:
- lang: eng
text: 'In the last few years, several new algorithms based on graph cuts have been
developed to solve energy minimization problems in computer vision. Each of these
techniques constructs a graph such that the minimum cut on the graph also minimizes
the energy. Yet because these graph constructions are complex and highly specific
to a particular energy function, graph cuts have seen limited application to date.
In this paper we characterize the energy functions that can be minimized by graph
cuts. Our results are restricted to energy functions with binary variables. However,
our work generalizes many previous constructions, and is easily applicable to
vision problems that involve large numbers of labels, such as stereo, motion,
image restoration and scene reconstruction. We present three main results: a necessary
condition for any energy function that can be minimized by graph cuts; a sufficient
condition for energy functions that can be written as a sum of functions of up
to three variables at a time; and a general-purpose construction to minimize such
an energy function. Researchers who are considering the use of graph cuts to optimize
a particular energy function can use our results to determine if this is possible,
and then follow our construction to create the appropriate graph.'
acknowledgement: We thank Olga Veksler and Yuri Boykov for their careful reading of
this paper, and for valuable comments which greatly improved itsreadibility. We
also thank Ian Jermyn for helping us clarify the paper’s motivation. This research
was supported by NSF grants IIS-9900115 and CCR-0113371, and by a grant from Microsoft
Research.
article_processing_charge: No
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: Ramin
full_name: Zabih, Ramin
last_name: Zabih
citation:
ama: 'Kolmogorov V, Zabih R. Multi-camera scene reconstruction via graph cuts. In:
Proceedings of the 7th European Conference on Computer Vision. Springer;
2002:65-81. doi:10.1007/3-540-47977-5_5'
apa: 'Kolmogorov, V., & Zabih, R. (2002). Multi-camera scene reconstruction
via graph cuts. In Proceedings of the 7th European Conference on Computer Vision
(pp. 65–81). Copenhagen, Denmark: Springer. https://doi.org/10.1007/3-540-47977-5_5'
chicago: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction
via Graph Cuts.” In Proceedings of the 7th European Conference on Computer
Vision, 65–81. Springer, 2002. https://doi.org/10.1007/3-540-47977-5_5.
ieee: V. Kolmogorov and R. Zabih, “Multi-camera scene reconstruction via graph cuts,”
in Proceedings of the 7th European Conference on Computer Vision, Copenhagen,
Denmark, 2002, pp. 65–81.
ista: 'Kolmogorov V, Zabih R. 2002. Multi-camera scene reconstruction via graph
cuts. Proceedings of the 7th European Conference on Computer Vision. ECCV: European
Conference on Computer Vision, 65–81.'
mla: Kolmogorov, Vladimir, and Ramin Zabih. “Multi-Camera Scene Reconstruction via
Graph Cuts.” Proceedings of the 7th European Conference on Computer Vision,
Springer, 2002, pp. 65–81, doi:10.1007/3-540-47977-5_5.
short: V. Kolmogorov, R. Zabih, in:, Proceedings of the 7th European Conference
on Computer Vision, Springer, 2002, pp. 65–81.
conference:
end_date: 2002-05-31
location: Copenhagen, Denmark
name: 'ECCV: European Conference on Computer Vision'
start_date: 2002-05-28
date_created: 2018-12-11T12:00:23Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-18T08:20:02Z
day: '01'
doi: 10.1007/3-540-47977-5_5
extern: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 65 - 81
publication: Proceedings of the 7th European Conference on Computer Vision
publication_identifier:
isbn:
- '9783540437468'
publication_status: published
publisher: Springer
publist_id: '3810'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multi-camera scene reconstruction via graph cuts
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2986'
abstract:
- lang: eng
text: Long-standing models propose that plant growth responses to light or gravity
are mediated by asymmetric distribution of the phytohormone auxin. Physiological
studies implicated a specific transport system that relocates auxin laterally,
thereby effecting differential growth; however, neither the molecular components
of this system nor the cellular mechanism of auxin redistribution on light or
gravity perception have been identified. Here, we show that auxin accumulates
asymmetrically during differential growth in an efflux-dependent manner. Mutations
in the Arabidopsis gene PIN3, a regulator of auxin efflux, alter differential
growth. PIN3 is expressed in gravity-sensing tissues, with PIN3 protein accumulating
predominantly at the lateral cell surface. PIN3 localizes to the plasma membrane
and to vesicles that cycle in an actin-dependent manner. In the root columella,
PIN3 is positioned symmetrically at the plasma membrane but rapidly relocalizes
laterally on gravity stimulation. Our data indicate that PIN3 is a component of
the lateral auxin transport system regulating tropic growth. In addition, actin-dependent
relocalization of PIN3 in response to gravity provides a mechanism for redirecting
auxin flux to trigger asymmetric growth.
acknowledgement: We thank G. Jürgens for enabling J.F. to accomplish part of this
work in his laboratory; P. Tänzler and M. Sauer for technical assistance; H. Vahlenkamp
for technical assistance in immunocytochemistry; M. Estelle for providing material
and suggestions; T. Altman for BAC filter sets; the ADIS (Automated DNA Isolation
and Sequencing) service group for DNA sequencing; ZIGIA (Center for Functional Genomics
in Arabidopsis) for the En lines; and N. Geldner, T. Hamann, G. Jürgens, K. Schrick
and C. Schwechheimer for comments and critical reading of the manuscript. This work
was supported by a fellowship of the DAAD (J.F.), the DFG (Schwerpunktprogramm Phytohormone),
the Fonds der chemischen Industrie, the European Communities Biotechnology Programs,
the INCO-Copernicus Program and the European Space Agency MAP-Biotechnology Programme
article_processing_charge: No
article_type: original
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Justyna
full_name: Wiśniewska, Justyna
last_name: Wiśniewska
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Kurt
full_name: Mendgen, Kurt
last_name: Mendgen
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. Lateral relocation of
auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 2002;415(6873):806-809.
doi:10.1038/415806a
apa: Friml, J., Wiśniewska, J., Benková, E., Mendgen, K., & Palme, K. (2002).
Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis.
Nature. Nature Publishing Group. https://doi.org/10.1038/415806a
chicago: Friml, Jiří, Justyna Wiśniewska, Eva Benková, Kurt Mendgen, and Klaus Palme.
“Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates Tropism in Arabidopsis.”
Nature. Nature Publishing Group, 2002. https://doi.org/10.1038/415806a.
ieee: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, and K. Palme, “Lateral relocation
of auxin efflux regulator PIN3 mediates tropism in Arabidopsis,” Nature,
vol. 415, no. 6873. Nature Publishing Group, pp. 806–809, 2002.
ista: Friml J, Wiśniewska J, Benková E, Mendgen K, Palme K. 2002. Lateral relocation
of auxin efflux regulator PIN3 mediates tropism in Arabidopsis. Nature. 415(6873),
806–809.
mla: Friml, Jiří, et al. “Lateral Relocation of Auxin Efflux Regulator PIN3 Mediates
Tropism in Arabidopsis.” Nature, vol. 415, no. 6873, Nature Publishing
Group, 2002, pp. 806–09, doi:10.1038/415806a.
short: J. Friml, J. Wiśniewska, E. Benková, K. Mendgen, K. Palme, Nature 415 (2002)
806–809.
date_created: 2018-12-11T12:00:42Z
date_published: 2002-02-14T00:00:00Z
date_updated: 2023-07-18T07:30:27Z
day: '14'
doi: 10.1038/415806a
extern: '1'
external_id:
pmid:
- '11845211 '
intvolume: ' 415'
issue: '6873'
language:
- iso: eng
month: '02'
oa_version: None
page: 806 - 809
pmid: 1
publication: Nature
publication_identifier:
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '3715'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lateral relocation of auxin efflux regulator PIN3 mediates tropism in Arabidopsis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 415
year: '2002'
...
---
_id: '2987'
abstract:
- lang: eng
text: The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype
that shows defective embryonic and seedling cell patterning, morphogenesis, and
root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase,
whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL
gene product. Seedlings mutant for each gene are similarly defective in the concentrations
of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed
misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal
cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses
to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene
signaling but not by exogenous sterols or brassinosteroids. We propose a model
in which correct sterol profiles are required for regulated auxin and ethylene
signaling through effects on membrane function.
acknowledgement: We thank Dr. Ken Feldmann for providing prospective hyd alleles,
Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing
ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline
Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham
Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological
Science Research Council research studentship to M.S., a Durham University studentship
to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330
to J.T.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
full_name: Souter, Martin
last_name: Souter
- first_name: Jennifer
full_name: Topping, Jennifer
last_name: Topping
- first_name: Margaret
full_name: Pullen, Margaret
last_name: Pullen
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Rachel
full_name: Hackett, Rachel
last_name: Hackett
- first_name: Don
full_name: Grierson, Don
last_name: Grierson
- first_name: Keith
full_name: Lindsey, Keith
last_name: Lindsey
citation:
ama: Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective
in sterol profiles and auxin and ethylene signaling. Plant Cell. 2002;14(5):1017-1031.
doi:10.1105/tpc.001248
apa: Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey,
K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
and ethylene signaling. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.001248
chicago: Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme,
Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis
Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” Plant Cell.
American Society of Plant Biologists, 2002. https://doi.org/10.1105/tpc.001248.
ieee: M. Souter et al., “Hydra mutants of Arabidopsis are defective in sterol
profiles and auxin and ethylene signaling,” Plant Cell, vol. 14, no. 5.
American Society of Plant Biologists, pp. 1017–1031, 2002.
ista: Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey
K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
and ethylene signaling. Plant Cell. 14(5), 1017–1031.
mla: Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol
Profiles and Auxin and Ethylene Signaling.” Plant Cell, vol. 14, no. 5,
American Society of Plant Biologists, 2002, pp. 1017–31, doi:10.1105/tpc.001248.
short: M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson,
K. Lindsey, Plant Cell 14 (2002) 1017–1031.
date_created: 2018-12-11T12:00:42Z
date_published: 2002-05-01T00:00:00Z
date_updated: 2023-07-18T07:34:32Z
day: '01'
doi: 10.1105/tpc.001248
extern: '1'
external_id:
pmid:
- '12034894'
intvolume: ' 14'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/
month: '05'
oa: 1
oa_version: None
page: 1017 - 1031
pmid: 1
publication: Plant Cell
publication_identifier:
issn:
- 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3716'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and
ethylene signaling
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 14
year: '2002'
...
---
_id: '2988'
abstract:
- lang: eng
text: Coordination of cell and tissue polarity commonly involves directional signaling
[1]. In the Arabidopsis root epidermis, cell polarity is revealed by basal, root
tip-oriented, hair outgrowth from hair-forming cells (trichoblasts) [2]. The plant
hormone auxin displays polar movements [1, 3] and accumulates at maximum concentration
in the root tip [4, 5]. The application of polar auxin transport inhibitors [3]
evokes changes in trichoblast polarity only at high concentrations and after long-term
application [2, 4]. Thus, it remains open whether components of the auxin transport
machinery mediate establishment of trichoblast polarity. Here we report that the
presumptive auxin influx carrier AUX1 [6, 7] contributes to apical-basal hair
cell polarity. AUX1 function is required for polarity changes induced by exogenous
application of the auxin 2,4-D, a preferential influx carrier substrate. Similar
to aux1 mutants, the vesicle trafficking inhibitor brefeldin A (BFA) interferes
with polar hair initiation, and AUX1 function is required for BFA-mediated polarity
changes. Consistently, BFA inhibits membrane trafficking of AUX1, trichoblast
hyperpolarization induced by 2,4-D, and alters the distal auxin maximum. Our results
identify AUX1 as one component of a novel BFA-sensitive auxin transport pathway
polarizing cells toward a hormone maximum.
article_processing_charge: No
article_type: original
author:
- first_name: Markus
full_name: Grebe, Markus
last_name: Grebe
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Maarten
full_name: Terlou, Maarten
last_name: Terlou
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
citation:
ama: Grebe M, Friml J, Swarup R, et al. Cell polarity signaling in Arabidopsis involves
a BFA sensitive auxin influx pathway. Current Biology. 2002;12(4):329-334.
doi:10.1016/S0960-9822(02)00654-1
apa: Grebe, M., Friml, J., Swarup, R., Ljung, K., Sandberg, G., Terlou, M., … Scheres,
B. (2002). Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin
influx pathway. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00654-1
chicago: Grebe, Markus, Jiří Friml, Ranjan Swarup, Karin Ljung, Göran Sandberg,
Maarten Terlou, Klaus Palme, Malcolm Bennett, and Ben Scheres. “Cell Polarity
Signaling in Arabidopsis Involves a BFA Sensitive Auxin Influx Pathway.” Current
Biology. Cell Press, 2002. https://doi.org/10.1016/S0960-9822(02)00654-1.
ieee: M. Grebe et al., “Cell polarity signaling in Arabidopsis involves a
BFA sensitive auxin influx pathway,” Current Biology, vol. 12, no. 4. Cell
Press, pp. 329–334, 2002.
ista: Grebe M, Friml J, Swarup R, Ljung K, Sandberg G, Terlou M, Palme K, Bennett
M, Scheres B. 2002. Cell polarity signaling in Arabidopsis involves a BFA sensitive
auxin influx pathway. Current Biology. 12(4), 329–334.
mla: Grebe, Markus, et al. “Cell Polarity Signaling in Arabidopsis Involves a BFA
Sensitive Auxin Influx Pathway.” Current Biology, vol. 12, no. 4, Cell
Press, 2002, pp. 329–34, doi:10.1016/S0960-9822(02)00654-1.
short: M. Grebe, J. Friml, R. Swarup, K. Ljung, G. Sandberg, M. Terlou, K. Palme,
M. Bennett, B. Scheres, Current Biology 12 (2002) 329–334.
date_created: 2018-12-11T12:00:43Z
date_published: 2002-02-19T00:00:00Z
date_updated: 2023-07-17T12:15:28Z
day: '19'
doi: 10.1016/S0960-9822(02)00654-1
extern: '1'
external_id:
pmid:
- '11864575'
intvolume: ' 12'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 329 - 334
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '3714'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell polarity signaling in Arabidopsis involves a BFA sensitive auxin influx
pathway
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '2002'
...
---
_id: '2989'
abstract:
- lang: eng
text: In contrast to animals, little is known about pattern formation in plants.
Physiological and genetic data suggest the involvement of the phytohormone auxin
in this process. Here, we characterize a novel member of the PIN family of putative
auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature
root meristems. Atpin4 mutants are defective in establishment and maintenance
of endogenous auxin gradients, fail to canalize externally applied auxin, and
display various patterning defects in both embryonic and seedling roots. We propose
a role for AtPIN4 in generating a sink for auxin below the quiescent center of
the root meristem that is essential for auxin distribution and patterning.
acknowledgement: We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for
technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus,
OH) and Thomas Altman for providing material. We also gratefully acknowledge the
ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics
in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly
Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading
of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer
Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm
Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen
Industrie, and the INCO-Copernicus Program.
article_processing_charge: No
article_type: original
author:
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Ikram
full_name: Blilou, Ikram
last_name: Blilou
- first_name: Justyna
full_name: Wiśniewska, Justyna
last_name: Wiśniewska
- first_name: Thorsten
full_name: Hamann, Thorsten
last_name: Hamann
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Scott
full_name: Woody, Scott
last_name: Woody
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Ben
full_name: Scheres, Ben
last_name: Scheres
- first_name: Gerd
full_name: Jürgens, Gerd
last_name: Jürgens
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Friml J, Benková E, Blilou I, et al. AtPIN4 mediates sink-driven auxin gradients
and root patterning in Arabidopsis. Cell. 2002;108(5):661-673. doi:10.1016/S0092-8674(02)00656-6
apa: Friml, J., Benková, E., Blilou, I., Wiśniewska, J., Hamann, T., Ljung, K.,
… Palme, K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning
in Arabidopsis. Cell. Cell Press. https://doi.org/10.1016/S0092-8674(02)00656-6
chicago: Friml, Jiří, Eva Benková, Ikram Blilou, Justyna Wiśniewska, Thorsten Hamann,
Karin Ljung, Scott Woody, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients
and Root Patterning in Arabidopsis.” Cell. Cell Press, 2002. https://doi.org/10.1016/S0092-8674(02)00656-6.
ieee: J. Friml et al., “AtPIN4 mediates sink-driven auxin gradients and root
patterning in Arabidopsis,” Cell, vol. 108, no. 5. Cell Press, pp. 661–673,
2002.
ista: Friml J, Benková E, Blilou I, Wiśniewska J, Hamann T, Ljung K, Woody S, Sandberg
G, Scheres B, Jürgens G, Palme K. 2002. AtPIN4 mediates sink-driven auxin gradients
and root patterning in Arabidopsis. Cell. 108(5), 661–673.
mla: Friml, Jiří, et al. “AtPIN4 Mediates Sink-Driven Auxin Gradients and Root Patterning
in Arabidopsis.” Cell, vol. 108, no. 5, Cell Press, 2002, pp. 661–73, doi:10.1016/S0092-8674(02)00656-6.
short: J. Friml, E. Benková, I. Blilou, J. Wiśniewska, T. Hamann, K. Ljung, S. Woody,
G. Sandberg, B. Scheres, G. Jürgens, K. Palme, Cell 108 (2002) 661–673.
date_created: 2018-12-11T12:00:43Z
date_published: 2002-03-08T00:00:00Z
date_updated: 2023-07-17T11:57:40Z
day: '08'
doi: 10.1016/S0092-8674(02)00656-6
extern: '1'
external_id:
pmid:
- '11893337'
intvolume: ' 108'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: None
page: 661 - 673
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '3713'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 108
year: '2002'
...