---
_id: '3614'
abstract:
- lang: eng
text: 'We analyze the changes in the mean and variance components of a quantitative
trait caused by changes in allele frequencies, concentrating on the effects of
genetic drift. We use a general representation of epistasis and dominance that
allows an arbitrary relation between genotype and phenotype for any number of
diallelic loci. We assume initial and final Hardy-Weinberg and linkage equilibrium
in our analyses of drift-induced changes. Random drift generates transient linkage
disequilibria that cause correlations between allele frequency fluctuations at
different loci. However, we show that these have negligible effects, at least
for interactions among small numbers of loci. Our analyses are based on diffusion
approximations that summarize the effects of drift in terms of F, the inbreeding
coefficient, interpreted as the expected proportional decrease in heterozygosity
at each locus. For haploids, the variance of the trait mean after a population
bottleneck is var(Δz̄) =inline imagewhere n is the number of loci contributing
to the trait variance, VA(1)=VA is the additive genetic variance, and VA(k) is
the kth-order additive epistatic variance. The expected additive genetic variance
after the bottleneck, denoted (V*A), is closely related to var(Δz̄);
(V*A) (1 –F)inline imageThus, epistasis inflates the expected additive variance
above VA(1 –F), the expectation under additivity. For haploids (and diploids without
dominance), the expected value of every variance component is inflated by the
existence of higher order interactions (e.g., third-order epistasis inflates (V*AA)).
This is not true in general with diploidy, because dominance alone can reduce
(V*A) below VA(1 –F) (e.g., when dominant alleles are rare). Without dominance,
diploidy produces simple expressions: var(Δz̄)=inline image=1 (2F)
kVA(k) and (V*A) = (1 –F)inline imagek(2F)k-1VA(k) With dominance (and even without
epistasis), var(Δz̄)and (V*A) no longer depend solely on the variance
components in the base population. For small F, the expected additive variance
simplifies to (V*A)(1 –F) VA+ 4FVAA+2FVD+2FCAD, where CAD is a sum of two terms
describing covariances between additive effects and dominance and additive × dominance
interactions. Whether population bottlenecks lead to expected increases in additive
variance depends primarily on the ratio of nonadditive to additive genetic variance
in the base population, but dominance precludes simple predictions based solely
on variance components. We illustrate these results using a model in which genotypic
values are drawn at random, allowing extreme and erratic epistatic interactions.
Although our analyses clarify the conditions under which drift is expected to
increase VA, we question the evolutionary importance of such increases.'
author:
- first_name: Nicholas H
full_name: Nicholas Barton
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: Barton NH, Turelli M. Effects of allele frequency changes on variance components
under a general model of epistasis. Evolution; International Journal of Organic
Evolution. 2004;58(10):2111-2132. doi:10.1111/j.0014-3820.2004.tb01591.x
apa: Barton, N. H., & Turelli, M. (2004). Effects of allele frequency changes
on variance components under a general model of epistasis. Evolution; International
Journal of Organic Evolution. Wiley-Blackwell. https://doi.org/10.1111/j.0014-3820.2004.tb01591.x
chicago: Barton, Nicholas H, and Michael Turelli. “Effects of Allele Frequency Changes
on Variance Components under a General Model of Epistasis.” Evolution; International
Journal of Organic Evolution. Wiley-Blackwell, 2004. https://doi.org/10.1111/j.0014-3820.2004.tb01591.x.
ieee: N. H. Barton and M. Turelli, “Effects of allele frequency changes on variance
components under a general model of epistasis,” Evolution; International Journal
of Organic Evolution, vol. 58, no. 10. Wiley-Blackwell, pp. 2111–2132, 2004.
ista: Barton NH, Turelli M. 2004. Effects of allele frequency changes on variance
components under a general model of epistasis. Evolution; International Journal
of Organic Evolution. 58(10), 2111–2132.
mla: Barton, Nicholas H., and Michael Turelli. “Effects of Allele Frequency Changes
on Variance Components under a General Model of Epistasis.” Evolution; International
Journal of Organic Evolution, vol. 58, no. 10, Wiley-Blackwell, 2004, pp.
2111–32, doi:10.1111/j.0014-3820.2004.tb01591.x.
short: N.H. Barton, M. Turelli, Evolution; International Journal of Organic Evolution
58 (2004) 2111–2132.
date_created: 2018-12-11T12:04:15Z
date_published: 2004-10-01T00:00:00Z
date_updated: 2021-01-12T07:44:40Z
day: '01'
doi: 10.1111/j.0014-3820.2004.tb01591.x
extern: 1
intvolume: ' 58'
issue: '10'
month: '10'
page: 2111 - 2132
publication: Evolution; International Journal of Organic Evolution
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2769'
quality_controlled: 0
status: public
title: Effects of allele frequency changes on variance components under a general
model of epistasis
type: journal_article
volume: 58
year: '2004'
...
---
_id: '3615'
abstract:
- lang: eng
text: 'We investigate three alternative selection-based scenarios proposed to maintain
polygenic variation: pleiotropic balancing selection, G x E interactions (with
spatial or temporal variation in allelic effects), and sex-dependent allelic effects.
Each analysis assumes an additive polygenic trait with n diallelic loci under
stabilizing selection. We allow loci to have different effects and consider equilibria
at which the population mean departs from the stabilizing-selection optimum. Under
weak selection, each model produces essentially identical, approximate allele-frequency
dynamics. Variation is maintained under pleiotropic balancing selection only at
loci for which the strength of balancing selection exceeds the effective strength
of stabilizing selection. In addition, for all models, polymorphism requires that
the population mean be close enough to the optimum that directional selection
does not overwhelm balancing selection. This balance allows many simultaneously
stable equilibria, and we explore their properties numerically. Both spatial and
temporal G x E can maintain variation at loci for which the coefficient of variation
(across environments) of the effect of a substitution exceeds a critical value
greater than one. The critical value depends on the correlation between substitution
effects at different loci. For large positive correlations (e.g., ρ2ij > 3/4),
even extreme fluctuations in allelic effects cannot maintain variation. Surprisingly,
this constraint on correlations implies that sex-dependent allelic effects cannot
maintain polygenic variation. We present numerical results that support our analytical
approximations and discuss our results in connection to relevant data and alternative
variance-maintaining mechanisms.'
author:
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
- first_name: Nicholas H
full_name: Nicholas Barton
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Turelli M, Barton NH. Polygenic variation maintained by balancing selection:
pleiotropy, sex-dependent allelic effects and GxE interactions. Genetics.
2004;166(2):1053-1079. doi:10.1534/genetics.166.2.1053'
apa: 'Turelli, M., & Barton, N. H. (2004). Polygenic variation maintained by
balancing selection: pleiotropy, sex-dependent allelic effects and GxE interactions.
Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.166.2.1053'
chicago: 'Turelli, Michael, and Nicholas H Barton. “Polygenic Variation Maintained
by Balancing Selection: Pleiotropy, Sex-Dependent Allelic Effects and GxE Interactions.”
Genetics. Genetics Society of America, 2004. https://doi.org/10.1534/genetics.166.2.1053.'
ieee: 'M. Turelli and N. H. Barton, “Polygenic variation maintained by balancing
selection: pleiotropy, sex-dependent allelic effects and GxE interactions,” Genetics,
vol. 166, no. 2. Genetics Society of America, pp. 1053–1079, 2004.'
ista: 'Turelli M, Barton NH. 2004. Polygenic variation maintained by balancing selection:
pleiotropy, sex-dependent allelic effects and GxE interactions. Genetics. 166(2),
1053–1079.'
mla: 'Turelli, Michael, and Nicholas H. Barton. “Polygenic Variation Maintained
by Balancing Selection: Pleiotropy, Sex-Dependent Allelic Effects and GxE Interactions.”
Genetics, vol. 166, no. 2, Genetics Society of America, 2004, pp. 1053–79,
doi:10.1534/genetics.166.2.1053.'
short: M. Turelli, N.H. Barton, Genetics 166 (2004) 1053–1079.
date_created: 2018-12-11T12:04:15Z
date_published: 2004-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:41Z
day: '01'
doi: 10.1534/genetics.166.2.1053
extern: 1
intvolume: ' 166'
issue: '2'
month: '02'
page: 1053 - 1079
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '2768'
quality_controlled: 0
status: public
title: 'Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent
allelic effects and GxE interactions'
type: journal_article
volume: 166
year: '2004'
...
---
_id: '3616'
author:
- first_name: Nicholas H
full_name: Nicholas Barton
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Speciation: Why, how, where and when? Current Biology. 2004;14(15):R603-R604.
doi:10.1016/j.cub.2004.07.037'
apa: 'Barton, N. H. (2004). Speciation: Why, how, where and when? Current Biology.
Cell Press. https://doi.org/10.1016/j.cub.2004.07.037'
chicago: 'Barton, Nicholas H. “Speciation: Why, How, Where and When?” Current
Biology. Cell Press, 2004. https://doi.org/10.1016/j.cub.2004.07.037.'
ieee: 'N. H. Barton, “Speciation: Why, how, where and when?,” Current Biology,
vol. 14, no. 15. Cell Press, pp. R603–R604, 2004.'
ista: 'Barton NH. 2004. Speciation: Why, how, where and when? Current Biology. 14(15),
R603–R604.'
mla: 'Barton, Nicholas H. “Speciation: Why, How, Where and When?” Current Biology,
vol. 14, no. 15, Cell Press, 2004, pp. R603–04, doi:10.1016/j.cub.2004.07.037.'
short: N.H. Barton, Current Biology 14 (2004) R603–R604.
date_created: 2018-12-11T12:04:16Z
date_published: 2004-08-10T00:00:00Z
date_updated: 2019-04-26T07:22:31Z
day: '10'
doi: 10.1016/j.cub.2004.07.037
extern: 1
intvolume: ' 14'
issue: '15'
month: '08'
page: R603 - R604
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '2767'
quality_controlled: 0
status: public
title: 'Speciation: Why, how, where and when?'
type: review
volume: 14
year: '2004'
...
---
_id: '3617'
abstract:
- lang: eng
text: 'The coalescent process can describe the effects of selection at linked loci
only if selection is so strong that genotype frequencies evolve deterministically.
Here, we develop methods proposed by Kaplan, Darden, and Hudson to find the effects
of weak selection. We show that the overall effect is given by an extension to
Price''s equation: the change in properties such as moments of coalescence times
is equal to the covariance between those properties and the fitness of the sample
of genes. The distribution of coalescence times differs substantially between
allelic classes, even in the absence of selection. However, the average coalescence
time between randomly chosen genes is insensitive to the current allele frequency
and is affected significantly by purifying selection only if deleterious mutations
are common and selection is strong (i.e., the product of population size and selection
coefficient, Ns > 3). Balancing selection increases mean coalescence times,
but the effect becomes large only when mutation rates between allelic classes
are low and when selection is extremely strong. Our analysis supports previous
simulations that show that selection has surprisingly little effect on genealogies.
Moreover, small fluctuations in allele frequency due to random drift can greatly
reduce any such effects. This will make it difficult to detect the action of selection
from neutral variation alone.'
author:
- first_name: Nicholas H
full_name: Nicholas Barton
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison M
last_name: Etheridge
citation:
ama: Barton NH, Etheridge A. The effect of selection on genealogies. Genetics.
2004;166(2):1115-1131. doi:10.1534/genetics.166.2.1115
apa: Barton, N. H., & Etheridge, A. (2004). The effect of selection on genealogies.
Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.166.2.1115
chicago: Barton, Nicholas H, and Alison Etheridge. “The Effect of Selection on Genealogies.”
Genetics. Genetics Society of America, 2004. https://doi.org/10.1534/genetics.166.2.1115.
ieee: N. H. Barton and A. Etheridge, “The effect of selection on genealogies,” Genetics,
vol. 166, no. 2. Genetics Society of America, pp. 1115–1131, 2004.
ista: Barton NH, Etheridge A. 2004. The effect of selection on genealogies. Genetics.
166(2), 1115–1131.
mla: Barton, Nicholas H., and Alison Etheridge. “The Effect of Selection on Genealogies.”
Genetics, vol. 166, no. 2, Genetics Society of America, 2004, pp. 1115–31,
doi:10.1534/genetics.166.2.1115.
short: N.H. Barton, A. Etheridge, Genetics 166 (2004) 1115–1131.
date_created: 2018-12-11T12:04:16Z
date_published: 2004-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:41Z
day: '01'
doi: 10.1534/genetics.166.2.1115
extern: 1
intvolume: ' 166'
issue: '2'
month: '02'
page: 1115 - 1131
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '2766'
quality_controlled: 0
status: public
title: The effect of selection on genealogies
type: journal_article
volume: 166
year: '2004'
...
---
_id: '3688'
abstract:
- lang: eng
text: Capturing images of documents using handheld digital cameras has a variety
of applications in academia, research, knowledge management, retail, and office
settings. The ultimate goal of such systems is to achieve image quality comparable
to that currently achieved with flatbed scanners even for curved, warped, or curled
pages. This can be achieved by high-accuracy 3D modeling of the page surface,
followed by a "flattening" of the surface. A number of previous systems
have either assumed only perspective distortions, or used techniques like structured
lighting, shading, or side-imaging for obtaining 3D shape. This paper describes
a system for handheld camera-based document capture using general purpose stereo
vision methods followed by a new document dewarping technique. Examples of shape
modeling and dewarping of book images is shown.
author:
- first_name: Adrian
full_name: Ulges, Adrian
last_name: Ulges
- first_name: Christoph
full_name: Christoph Lampert
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Thomas
full_name: Breuel,Thomas M
last_name: Breuel
citation:
ama: 'Ulges A, Lampert C, Breuel T. Document capture using stereo vision. In: ACM;
2004:198-200. doi:10.1145/1030397.1030434'
apa: 'Ulges, A., Lampert, C., & Breuel, T. (2004). Document capture using stereo
vision (pp. 198–200). Presented at the DocEng: ACM Symposium on Document Engineering,
ACM. https://doi.org/10.1145/1030397.1030434'
chicago: Ulges, Adrian, Christoph Lampert, and Thomas Breuel. “Document Capture
Using Stereo Vision,” 198–200. ACM, 2004. https://doi.org/10.1145/1030397.1030434.
ieee: 'A. Ulges, C. Lampert, and T. Breuel, “Document capture using stereo vision,”
presented at the DocEng: ACM Symposium on Document Engineering, 2004, pp. 198–200.'
ista: 'Ulges A, Lampert C, Breuel T. 2004. Document capture using stereo vision.
DocEng: ACM Symposium on Document Engineering, 198–200.'
mla: Ulges, Adrian, et al. Document Capture Using Stereo Vision. ACM, 2004,
pp. 198–200, doi:10.1145/1030397.1030434.
short: A. Ulges, C. Lampert, T. Breuel, in:, ACM, 2004, pp. 198–200.
conference:
name: 'DocEng: ACM Symposium on Document Engineering'
date_created: 2018-12-11T12:04:38Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:48:58Z
day: '01'
doi: 10.1145/1030397.1030434
extern: 1
main_file_link:
- open_access: '0'
url: http://pub.ist.ac.at/~chl/papers/ulges-doceng2004.pdf
month: '01'
page: 198 - 200
publication_status: published
publisher: ACM
publist_id: '2679'
quality_controlled: 0
status: public
title: Document capture using stereo vision
type: conference
year: '2004'
...
---
_id: '3805'
abstract:
- lang: eng
text: The operation of neuronal networks crucially depends on a fast time course
of signaling in inhibitory interneurons. Synapses that excite interneurons generate
fast currents, owing to the expression of glutamate receptors of specific subunit
composition. Interneurons generate brief action potentials in response to transient
synaptic activation and discharge repetitively at very high frequencies during
sustained stimulation. The ability to generate short-duration action potentials
at high frequencies depends on the expression of specific voltage-gated K+ channels.
Factors facilitating fast action potential initiation following synaptic excitation
include depolarized interneuron resting potential, subthreshold conductances and
active dendrites. Finally, GABA release at interneuron output synapses is rapid
and highly synchronized, leading to a faster inhibition in postsynaptic interneurons
than in principal cells. Thus, the expression of distinct transmitter receptors
and voltage-gated ion channels ensures that interneurons operate with high speed
and temporal precision.
author:
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Desdemona
full_name: Fricker, Desdemona
last_name: Fricker
- first_name: Richard
full_name: Miles, Richard
last_name: Miles
citation:
ama: 'Jonas PM, Bischofberger J, Fricker D, Miles R. Interneuron Diversity series:
Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons.
Trends in Neurosciences. 2004;27(1):30-40. doi:doi:10.1016/j.tins.2003.10.010'
apa: 'Jonas, P. M., Bischofberger, J., Fricker, D., & Miles, R. (2004). Interneuron
Diversity series: Fast in, fast out--temporal and spatial signal processing in
hippocampal interneurons. Trends in Neurosciences. Elsevier. https://doi.org/doi:10.1016/j.tins.2003.10.010'
chicago: 'Jonas, Peter M, Josef Bischofberger, Desdemona Fricker, and Richard Miles.
“Interneuron Diversity Series: Fast in, Fast out--Temporal and Spatial Signal
Processing in Hippocampal Interneurons.” Trends in Neurosciences. Elsevier,
2004. https://doi.org/doi:10.1016/j.tins.2003.10.010.'
ieee: 'P. M. Jonas, J. Bischofberger, D. Fricker, and R. Miles, “Interneuron Diversity
series: Fast in, fast out--temporal and spatial signal processing in hippocampal
interneurons,” Trends in Neurosciences, vol. 27, no. 1. Elsevier, pp. 30–40,
2004.'
ista: 'Jonas PM, Bischofberger J, Fricker D, Miles R. 2004. Interneuron Diversity
series: Fast in, fast out--temporal and spatial signal processing in hippocampal
interneurons. Trends in Neurosciences. 27(1), 30–40.'
mla: 'Jonas, Peter M., et al. “Interneuron Diversity Series: Fast in, Fast out--Temporal
and Spatial Signal Processing in Hippocampal Interneurons.” Trends in Neurosciences,
vol. 27, no. 1, Elsevier, 2004, pp. 30–40, doi:doi:10.1016/j.tins.2003.10.010.'
short: P.M. Jonas, J. Bischofberger, D. Fricker, R. Miles, Trends in Neurosciences
27 (2004) 30–40.
date_created: 2018-12-11T12:05:16Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:19Z
day: '01'
doi: doi:10.1016/j.tins.2003.10.010
extern: 1
intvolume: ' 27'
issue: '1'
month: '01'
page: 30 - 40
publication: Trends in Neurosciences
publication_status: published
publisher: Elsevier
publist_id: '2404'
quality_controlled: 0
status: public
title: 'Interneuron Diversity series: Fast in, fast out--temporal and spatial signal
processing in hippocampal interneurons'
type: journal_article
volume: 27
year: '2004'
...
---
_id: '3807'
abstract:
- lang: eng
text: The time course of Mg(2+) block and unblock of NMDA receptors (NMDARs) determines
the extent they are activated by depolarization. Here, we directly measure the
rate of NMDAR channel opening in response to depolarizations at different times
after brief (1 ms) and sustained (4.6 s) applications of glutamate to nucleated
patches from neocortical pyramidal neurons. The kinetics of Mg(2+) unblock were
found to be non-instantaneous and complex, consisting of a prominent fast component
(time constant approximately 100 micros) and slower components (time constants
4 and approximately 300 ms), the relative amplitudes of which depended on the
timing of the depolarizing pulse. Fitting a kinetic model to these data indicated
that Mg(2+) not only blocks the NMDAR channel, but reduces both the open probability
and affinity for glutamate, while enhancing desensitization. These effects slow
the rate of NMDAR channel opening in response to depolarization in a time-dependent
manner such that the slower components of Mg(2+) unblock are enhanced during depolarizations
at later times after glutamate application. One physiological consequence of this
is that brief depolarizations occurring earlier in time after glutamate application
are better able to open NMDAR channels. This finding has important implications
for spike-timing-dependent synaptic plasticity (STDP), where the precise (millisecond)
timing of action potentials relative to synaptic inputs determines the magnitude
and sign of changes in synaptic strength. Indeed, we find that STDP timing curves
of NMDAR channel activation elicited by realistic dendritic action potential waveforms
are narrower than expected assuming instantaneous Mg(2+) unblock, indicating that
slow Mg(2+) unblock of NMDAR channels makes the STDP timing window more precise.
author:
- first_name: Bjorn
full_name: Kampa, Bjorn M
last_name: Kampa
- first_name: John
full_name: Clements, John
last_name: Clements
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Greg
full_name: Stuart, Greg J
last_name: Stuart
citation:
ama: 'Kampa B, Clements J, Jonas PM, Stuart G. Kinetics of Mg(2+) unblock of NMDA
receptors: implications for spike-timing dependent synaptic plasticity. Journal
of Physiology. 2004;556(Pt 2):337-345. doi:10.1113/jphysiol.2003.058842 '
apa: 'Kampa, B., Clements, J., Jonas, P. M., & Stuart, G. (2004). Kinetics of
Mg(2+) unblock of NMDA receptors: implications for spike-timing dependent synaptic
plasticity. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.2003.058842 '
chicago: 'Kampa, Bjorn, John Clements, Peter M Jonas, and Greg Stuart. “Kinetics
of Mg(2+) Unblock of NMDA Receptors: Implications for Spike-Timing Dependent Synaptic
Plasticity.” Journal of Physiology. Wiley-Blackwell, 2004. https://doi.org/10.1113/jphysiol.2003.058842 .'
ieee: 'B. Kampa, J. Clements, P. M. Jonas, and G. Stuart, “Kinetics of Mg(2+) unblock
of NMDA receptors: implications for spike-timing dependent synaptic plasticity,”
Journal of Physiology, vol. 556, no. Pt 2. Wiley-Blackwell, pp. 337–45,
2004.'
ista: 'Kampa B, Clements J, Jonas PM, Stuart G. 2004. Kinetics of Mg(2+) unblock
of NMDA receptors: implications for spike-timing dependent synaptic plasticity.
Journal of Physiology. 556(Pt 2), 337–45.'
mla: 'Kampa, Bjorn, et al. “Kinetics of Mg(2+) Unblock of NMDA Receptors: Implications
for Spike-Timing Dependent Synaptic Plasticity.” Journal of Physiology,
vol. 556, no. Pt 2, Wiley-Blackwell, 2004, pp. 337–45, doi:10.1113/jphysiol.2003.058842 .'
short: B. Kampa, J. Clements, P.M. Jonas, G. Stuart, Journal of Physiology 556 (2004)
337–45.
date_created: 2018-12-11T12:05:17Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:20Z
day: '01'
doi: '10.1113/jphysiol.2003.058842 '
extern: 1
intvolume: ' 556'
issue: Pt 2
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664940/
month: '01'
oa: 1
page: 337 - 45
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2403'
quality_controlled: 0
status: public
title: 'Kinetics of Mg(2+) unblock of NMDA receptors: implications for spike-timing
dependent synaptic plasticity'
type: journal_article
volume: 556
year: '2004'
...
---
_id: '3809'
abstract:
- lang: eng
text: Neural stem cells in various regions of the vertebrate brain continuously
generate neurons throughout life. In the mammalian hippocampus, a region important
for spatial and episodic memory, thousands of new granule cells are produced per
day, with the exact number depending on environmental conditions and physical
exercise. The survival of these neurons is improved by learning and conversely
learning may be promoted by neurogenesis. Although it has been suggested that
newly generated neurons may have specific properties to facilitate learning, the
cellular and synaptic mechanisms of plasticity in these neurons are largely unknown.
Here we show that young granule cells in the adult hippocampus differ substantially
from mature granule cells in both active and passive membrane properties. In young
neurons, T-type Ca2+ channels can generate isolated Ca2+ spikes and boost fast
Na+ action potentials, contributing to the induction of synaptic plasticity. Associative
long-term potentiation can be induced more easily in young neurons than in mature
neurons under identical conditions. Thus, newly generated neurons express unique
mechanisms to facilitate synaptic plasticity, which may be important for the formation
of new memories.
author:
- first_name: Christoph
full_name: Schmidt-Hieber, Christoph
last_name: Schmidt Hieber
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
citation:
ama: Schmidt Hieber C, Jonas PM, Bischofberger J. Enhanced synaptic plasticity in
newly generated granule cells of the adult hippocampus. Nature. 2004;429(6988):184-187.
doi:10.1038/nature02553
apa: Schmidt Hieber, C., Jonas, P. M., & Bischofberger, J. (2004). Enhanced
synaptic plasticity in newly generated granule cells of the adult hippocampus.
Nature. Nature Publishing Group. https://doi.org/10.1038/nature02553
chicago: Schmidt Hieber, Christoph, Peter M Jonas, and Josef Bischofberger. “Enhanced
Synaptic Plasticity in Newly Generated Granule Cells of the Adult Hippocampus.”
Nature. Nature Publishing Group, 2004. https://doi.org/10.1038/nature02553.
ieee: C. Schmidt Hieber, P. M. Jonas, and J. Bischofberger, “Enhanced synaptic plasticity
in newly generated granule cells of the adult hippocampus,” Nature, vol.
429, no. 6988. Nature Publishing Group, pp. 184–7, 2004.
ista: Schmidt Hieber C, Jonas PM, Bischofberger J. 2004. Enhanced synaptic plasticity
in newly generated granule cells of the adult hippocampus. Nature. 429(6988),
184–7.
mla: Schmidt Hieber, Christoph, et al. “Enhanced Synaptic Plasticity in Newly Generated
Granule Cells of the Adult Hippocampus.” Nature, vol. 429, no. 6988, Nature
Publishing Group, 2004, pp. 184–87, doi:10.1038/nature02553.
short: C. Schmidt Hieber, P.M. Jonas, J. Bischofberger, Nature 429 (2004) 184–7.
date_created: 2018-12-11T12:05:17Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:21Z
day: '01'
doi: 10.1038/nature02553
extern: 1
intvolume: ' 429'
issue: '6988'
month: '01'
page: 184 - 7
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '2401'
quality_controlled: 0
status: public
title: Enhanced synaptic plasticity in newly generated granule cells of the adult
hippocampus
type: journal_article
volume: 429
year: '2004'
...
---
_id: '3810'
abstract:
- lang: eng
text: Voltage-gated potassium (Kv) channels control action potential repolarization,
interspike membrane potential, and action potential frequency in excitable cells.
It is thought that the combinatorial association between distinct alpha and beta
subunits determines whether Kv channels function as non-inactivating delayed rectifiers
or as rapidly inactivating A-type channels. We show that membrane lipids can convert
A-type channels into delayed rectifiers and vice versa. Phosphoinositides remove
N-type inactivation from A-type channels by immobilizing the inactivation domains.
Conversely, arachidonic acid and its amide anandamide endow delayed rectifiers
with rapid voltage-dependent inactivation. The bidirectional control of Kv channel
gating by lipids may provide a mechanism for the dynamic regulation of electrical
signaling in the nervous system.
author:
- first_name: Dominik
full_name: Oliver, Dominik
last_name: Oliver
- first_name: Cheng
full_name: Lien, Cheng-Chang
last_name: Lien
- first_name: Malle
full_name: Soom, Malle
last_name: Soom
- first_name: Thomas
full_name: Baukrowitz, Thomas
last_name: Baukrowitz
- first_name: Peter M
full_name: Peter Jonas
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bernd
full_name: Fakler, Bernd
last_name: Fakler
citation:
ama: Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. Functional conversion
between A-type and delayed rectifier K+ channels by membrane lipids. Science.
2004;304(5668):265-270. doi:10.1126/science.1094113
apa: Oliver, D., Lien, C., Soom, M., Baukrowitz, T., Jonas, P. M., & Fakler,
B. (2004). Functional conversion between A-type and delayed rectifier K+ channels
by membrane lipids. Science. American Association for the Advancement of
Science. https://doi.org/10.1126/science.1094113
chicago: Oliver, Dominik, Cheng Lien, Malle Soom, Thomas Baukrowitz, Peter M Jonas,
and Bernd Fakler. “Functional Conversion between A-Type and Delayed Rectifier
K+ Channels by Membrane Lipids.” Science. American Association for the
Advancement of Science, 2004. https://doi.org/10.1126/science.1094113.
ieee: D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P. M. Jonas, and B. Fakler, “Functional
conversion between A-type and delayed rectifier K+ channels by membrane lipids,”
Science, vol. 304, no. 5668. American Association for the Advancement of
Science, pp. 265–70, 2004.
ista: Oliver D, Lien C, Soom M, Baukrowitz T, Jonas PM, Fakler B. 2004. Functional
conversion between A-type and delayed rectifier K+ channels by membrane lipids.
Science. 304(5668), 265–70.
mla: Oliver, Dominik, et al. “Functional Conversion between A-Type and Delayed Rectifier
K+ Channels by Membrane Lipids.” Science, vol. 304, no. 5668, American
Association for the Advancement of Science, 2004, pp. 265–70, doi:10.1126/science.1094113.
short: D. Oliver, C. Lien, M. Soom, T. Baukrowitz, P.M. Jonas, B. Fakler, Science
304 (2004) 265–70.
date_created: 2018-12-11T12:05:18Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:22Z
day: '01'
doi: 10.1126/science.1094113
extern: 1
intvolume: ' 304'
issue: '5668'
month: '01'
page: 265 - 70
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2402'
quality_controlled: 0
status: public
title: Functional conversion between A-type and delayed rectifier K+ channels by membrane
lipids
type: journal_article
volume: 304
year: '2004'
...
---
_id: '3894'
abstract:
- lang: eng
text: We study infinite stochastic games played by n-players on a finite graph with
goals given by sets of infinite traces. The games are stochastic (each player
simultaneously and independently chooses an action at each round, and the next
state is determined by a probability distribution depending on the current state
and the chosen actions), infinite (the game continues for an infinite number of
rounds), nonzero sum (the players' goals are not necessarily conflicting), and
undiscounted. We show that if each player has a reachability objective, that is,
if the goal for each player i is to visit some subset R-i of the states, then
there exists an epsilon-Nash equilibrium in memoryless strategies, for every epsilon
> 0. However, exact Nash equilibria need not exist. We study the complexity
of finding such Nash equilibria, and show that the payoff of some epsilon-Nash
equilibrium in memoryless strategies can be epsilon-approximated in NP. We study
the important subclass of n-player turn-based probabilistic games, where at each
state at most one player has a nontrivial choice of moves. For turn-based probabilistic
games, we show the existence of epsilon-Nash equilibria in pure strategies for
games where the objective of player i is a Borel set B-i of infinite traces. However,
exact Nash equilibria may not exist. For the special case of omega-regular objectives,
we show exact Nash equilibria exist, and can be computed in NP when the omega-regular
objectives are expressed as parity objectives.
acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
ONR grant N00014-02-1-0671, NSF grants CCR-9988172 and CCR-0225610
alternative_title:
- 'LNCS '
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Ritankar
full_name: Majumdar, Ritankar S
last_name: Majumdar
- first_name: Marcin
full_name: Jurdziński, Marcin
last_name: Jurdziński
citation:
ama: 'Chatterjee K, Majumdar R, Jurdziński M. On Nash equilibria in stochastic games.
In: Vol 3210. Springer; 2004:26-40. doi:10.1007/978-3-540-30124-0_6'
apa: 'Chatterjee, K., Majumdar, R., & Jurdziński, M. (2004). On Nash equilibria
in stochastic games (Vol. 3210, pp. 26–40). Presented at the CSL: Computer Science
Logic, Springer. https://doi.org/10.1007/978-3-540-30124-0_6'
chicago: Chatterjee, Krishnendu, Ritankar Majumdar, and Marcin Jurdziński. “On Nash
Equilibria in Stochastic Games,” 3210:26–40. Springer, 2004. https://doi.org/10.1007/978-3-540-30124-0_6.
ieee: 'K. Chatterjee, R. Majumdar, and M. Jurdziński, “On Nash equilibria in stochastic
games,” presented at the CSL: Computer Science Logic, 2004, vol. 3210, pp. 26–40.'
ista: 'Chatterjee K, Majumdar R, Jurdziński M. 2004. On Nash equilibria in stochastic
games. CSL: Computer Science Logic, LNCS , vol. 3210, 26–40.'
mla: Chatterjee, Krishnendu, et al. On Nash Equilibria in Stochastic Games.
Vol. 3210, Springer, 2004, pp. 26–40, doi:10.1007/978-3-540-30124-0_6.
short: K. Chatterjee, R. Majumdar, M. Jurdziński, in:, Springer, 2004, pp. 26–40.
conference:
name: 'CSL: Computer Science Logic'
date_created: 2018-12-11T12:05:45Z
date_published: 2004-09-09T00:00:00Z
date_updated: 2021-01-12T07:53:01Z
day: '09'
doi: 10.1007/978-3-540-30124-0_6
extern: 1
intvolume: ' 3210'
month: '09'
page: 26 - 40
publication_status: published
publisher: Springer
publist_id: '2264'
quality_controlled: 0
status: public
title: On Nash equilibria in stochastic games
type: conference
volume: 3210
year: '2004'
...
---
_id: '3895'
abstract:
- lang: eng
text: 'In 2-player non-zero-sum games, Nash equilibria capture the options for rational
behavior if each player attempts to maximize her payoff. In contrast to classical
game theory, we consider lexicographic objectives: first, each player tries to
maximize her own payoff, and then, the player tries to minimize the opponent''s
payoff. Such objectives arise naturally in the verification of systems with multiple
components. There, instead of proving that each component satisfies its specification
no matter how the other components behave, it often suffices to prove that each
component satisfies its specification provided that the other components satisfy
their specifications. We say that a Nash equilibrium is secure if it is an equilibrium
with respect to the lexicographic objectives of both players. We prove that in
graph games with Borel objectives, which include the games that arise in verification,
there may be several Nash equilibria, but there is always a unique maximal payoff
profile of secure equilibria. We show how this equilibrium can be computed in
the case of omega-regular objectives, and we characterize the memory requirements
of strategies that achieve the equilibrium.'
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Thomas Henzinger
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Marcin
full_name: Jurdziński, Marcin
last_name: Jurdziński
citation:
ama: 'Chatterjee K, Henzinger TA, Jurdziński M. Games with secure equilibria. In:
IEEE; 2004:160-169. doi:10.1109/LICS.2004.1319610'
apa: 'Chatterjee, K., Henzinger, T. A., & Jurdziński, M. (2004). Games with
secure equilibria (pp. 160–169). Presented at the LICS: Logic in Computer Science,
IEEE. https://doi.org/10.1109/LICS.2004.1319610'
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Marcin Jurdziński. “Games
with Secure Equilibria,” 160–69. IEEE, 2004. https://doi.org/10.1109/LICS.2004.1319610.
ieee: 'K. Chatterjee, T. A. Henzinger, and M. Jurdziński, “Games with secure equilibria,”
presented at the LICS: Logic in Computer Science, 2004, pp. 160–169.'
ista: 'Chatterjee K, Henzinger TA, Jurdziński M. 2004. Games with secure equilibria.
LICS: Logic in Computer Science, 160–169.'
mla: Chatterjee, Krishnendu, et al. Games with Secure Equilibria. IEEE, 2004,
pp. 160–69, doi:10.1109/LICS.2004.1319610.
short: K. Chatterjee, T.A. Henzinger, M. Jurdziński, in:, IEEE, 2004, pp. 160–169.
conference:
name: 'LICS: Logic in Computer Science'
date_created: 2018-12-11T12:05:45Z
date_published: 2004-08-09T00:00:00Z
date_updated: 2021-01-12T07:53:01Z
day: '09'
doi: 10.1109/LICS.2004.1319610
extern: 1
month: '08'
page: 160 - 169
publication_status: published
publisher: IEEE
publist_id: '2262'
quality_controlled: 0
status: public
title: Games with secure equilibria
type: conference
year: '2004'
...
---
_id: '3918'
abstract:
- lang: eng
text: Wingless (ergatoid) males of the tramp ant Cardiocondyla minutior attack and
kill their young ergatoid rivals and thus attempt to monopolize mating with female
sexuals reared in the colony. Because of the different strength of local mate
competition in colonies with one or several reproductive queens, we expected the
production of new ergatoid males to vary with queen number. Sex ratios were mostly
female-biased, but in contrast to the sympatric species C. obscurior (Cremer and
Heinze, 2002) neither the percentage of ergatoid males nor of female sexuals among
the first 20 sexuals produced varied considerably with queen number. As in C.
obscurior, experimental colony fragmentation led to the production of winged males,
whereas in unfragmented control colonies only ergatoid males eclosed.
author:
- first_name: Jürgen
full_name: Heinze, Jürgen
last_name: Heinze
- first_name: A.
full_name: Böttcher, A.
last_name: Böttcher
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Heinze J, Böttcher A, Cremer S. Production of winged and wingless males in
the ant, Cardiocondyla minutior. Insectes Sociaux. 2004;51(3):275-278.
doi:10.1007/s00040-004-0740-6
apa: Heinze, J., Böttcher, A., & Cremer, S. (2004). Production of winged and
wingless males in the ant, Cardiocondyla minutior. Insectes Sociaux. Springer.
https://doi.org/10.1007/s00040-004-0740-6
chicago: Heinze, Jürgen, A. Böttcher, and Sylvia Cremer. “Production of Winged and
Wingless Males in the Ant, Cardiocondyla Minutior.” Insectes Sociaux. Springer,
2004. https://doi.org/10.1007/s00040-004-0740-6.
ieee: J. Heinze, A. Böttcher, and S. Cremer, “Production of winged and wingless
males in the ant, Cardiocondyla minutior,” Insectes Sociaux, vol. 51, no.
3. Springer, pp. 275–278, 2004.
ista: Heinze J, Böttcher A, Cremer S. 2004. Production of winged and wingless males
in the ant, Cardiocondyla minutior. Insectes Sociaux. 51(3), 275–278.
mla: Heinze, Jürgen, et al. “Production of Winged and Wingless Males in the Ant,
Cardiocondyla Minutior.” Insectes Sociaux, vol. 51, no. 3, Springer, 2004,
pp. 275–78, doi:10.1007/s00040-004-0740-6.
short: J. Heinze, A. Böttcher, S. Cremer, Insectes Sociaux 51 (2004) 275–278.
date_created: 2018-12-11T12:05:53Z
date_published: 2004-08-19T00:00:00Z
date_updated: 2021-01-12T07:53:11Z
day: '19'
doi: 10.1007/s00040-004-0740-6
extern: '1'
intvolume: ' 51'
issue: '3'
language:
- iso: eng
month: '08'
oa_version: None
page: 275 - 278
publication: Insectes Sociaux
publication_status: published
publisher: Springer
publist_id: '2236'
status: public
title: Production of winged and wingless males in the ant, Cardiocondyla minutior
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2004'
...
---
_id: '3929'
abstract:
- lang: eng
text: The Nef protein of human and simian immunodeficiency virus (HIV/SIV) is believed
to interfere with T cell activation signals by forming a signaling complex at
the plasma membrane. Composition and function of the complex are not fully understood.
Here we report that Nef recruits the Polycomb Group (PcG) protein Eed, so far
known as a nuclear factor and repressor of transcription, to the membrane of cells.
The Nef-induced translocation of Eed led to a potent stimulation of Tat-dependent
HIV transcription, implying that Eed removal from the nucleus is required for
optimal Tat function. Similar to Nef action, activation of integrin receptors
recruited Eed to the plasma membrane, also leading to enhanced Tat/Nef-mediated
transcription. Our results suggest a link between membrane-associated activation
processes and transcriptional derepression and demonstrate how HIV exploits this
mechanism.
author:
- first_name: Vanessa
full_name: Witte, Vanessa
last_name: Witte
- first_name: Bernd
full_name: Laffert, Bernd
last_name: Laffert
- first_name: Olaf
full_name: Rosorius, Olaf
last_name: Rosorius
- first_name: Peter
full_name: Lischka, Peter
last_name: Lischka
- first_name: Katja
full_name: Blume, Katja
last_name: Blume
- first_name: Gunther
full_name: Galler, Gunther
last_name: Galler
- first_name: Andrea
full_name: Stilper, Andrea
last_name: Stilper
- first_name: Dieter
full_name: Willbold, Dieter
last_name: Willbold
- first_name: Paola
full_name: D'Aloja, Paola
last_name: D'Aloja
- first_name: Michael K
full_name: Michael Sixt
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Johanna
full_name: Kolanus, Johanna
last_name: Kolanus
- first_name: Melanie
full_name: Ott, Melanie
last_name: Ott
- first_name: Waldemar
full_name: Kolanus, Waldemar
last_name: Kolanus
- first_name: Gerold
full_name: Schuler, Gerold
last_name: Schuler
- first_name: Andreas
full_name: Baur, Andreas S
last_name: Baur
citation:
ama: Witte V, Laffert B, Rosorius O, et al. HIV-1 Nef mimics an integrin receptor
signal that recruits the polycomb group protein Eed to the plasma membrane. Molecular
Cell. 2004;13(2):179-190. doi:10.1016/S1097-2765(04)00004-8
apa: Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., …
Baur, A. (2004). HIV-1 Nef mimics an integrin receptor signal that recruits the
polycomb group protein Eed to the plasma membrane. Molecular Cell. Cell
Press. https://doi.org/10.1016/S1097-2765(04)00004-8
chicago: Witte, Vanessa, Bernd Laffert, Olaf Rosorius, Peter Lischka, Katja Blume,
Gunther Galler, Andrea Stilper, et al. “HIV-1 Nef Mimics an Integrin Receptor
Signal That Recruits the Polycomb Group Protein Eed to the Plasma Membrane.” Molecular
Cell. Cell Press, 2004. https://doi.org/10.1016/S1097-2765(04)00004-8.
ieee: V. Witte et al., “HIV-1 Nef mimics an integrin receptor signal that
recruits the polycomb group protein Eed to the plasma membrane,” Molecular
Cell, vol. 13, no. 2. Cell Press, pp. 179–190, 2004.
ista: Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold
D, D’Aloja P, Sixt MK, Kolanus J, Ott M, Kolanus W, Schuler G, Baur A. 2004. HIV-1
Nef mimics an integrin receptor signal that recruits the polycomb group protein
Eed to the plasma membrane. Molecular Cell. 13(2), 179–190.
mla: Witte, Vanessa, et al. “HIV-1 Nef Mimics an Integrin Receptor Signal That Recruits
the Polycomb Group Protein Eed to the Plasma Membrane.” Molecular Cell,
vol. 13, no. 2, Cell Press, 2004, pp. 179–90, doi:10.1016/S1097-2765(04)00004-8.
short: V. Witte, B. Laffert, O. Rosorius, P. Lischka, K. Blume, G. Galler, A. Stilper,
D. Willbold, P. D’Aloja, M.K. Sixt, J. Kolanus, M. Ott, W. Kolanus, G. Schuler,
A. Baur, Molecular Cell 13 (2004) 179–190.
date_created: 2018-12-11T12:05:56Z
date_published: 2004-01-30T00:00:00Z
date_updated: 2021-01-12T07:53:16Z
day: '30'
doi: 10.1016/S1097-2765(04)00004-8
extern: 1
intvolume: ' 13'
issue: '2'
month: '01'
page: 179 - 190
publication: Molecular Cell
publication_status: published
publisher: Cell Press
publist_id: '2197'
quality_controlled: 0
status: public
title: HIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group
protein Eed to the plasma membrane
type: journal_article
volume: 13
year: '2004'
...
---
_id: '3931'
abstract:
- lang: eng
text: Hyaluronan is an unsulfated glycosaminoglycan (GAG) that is ubiquitously expressed
in the extracellular matrix (ECM) of all vertebrates, where hyaluronan rich matrices
constitute a particular permissive environment for the development of complex
biological structures and also for tumor progression. Because of its conserved
structure and ubiquitous expression, antibodies for its histochemical detection
cannot be produced. We have engineered a fusion protein, neurocan-GFP, and expressed
it as a secreted molecule in mammalian cells. Neurocan-GFP fusion protein specifically
binds to hyaluronan and directly visualizes hyaluronan on tissue sections, revealing
a very detailed picture of hyaluronan distribution. The fluorescent fusion protein
can be used in combination with antibodies and nuclear markers for double or triple
staining. In addition, it is suitable to visualize hyaluronan on living cells
by time-lapse video microscopy. The successful production and application of the
neurocan-GFP fusion protein opens up new perspectives for using GFP fusion proteins
as detection tools in histological and cytological studies complementing conventional
antibody and biotin/avidin techniques.
author:
- first_name: Hui
full_name: Zhang, Hui
last_name: Zhang
- first_name: Stephan
full_name: Baader, Stephan L
last_name: Baader
- first_name: Michael K
full_name: Michael Sixt
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Joachim
full_name: Kappler, Joachim
last_name: Kappler
- first_name: Uwe
full_name: Rauch, Uwe
last_name: Rauch
citation:
ama: 'Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. Neurocan-GFP fusion protein:
a new approach to detect hyaluronan on tissue sections and living cells. Journal
of Histochemistry and Cytochemistry. 2004;52(7):915-922. doi:10.1369/jhc.3A6221.2004'
apa: 'Zhang, H., Baader, S., Sixt, M. K., Kappler, J., & Rauch, U. (2004). Neurocan-GFP
fusion protein: a new approach to detect hyaluronan on tissue sections and living
cells. Journal of Histochemistry and Cytochemistry. Histochemical Society.
https://doi.org/10.1369/jhc.3A6221.2004'
chicago: 'Zhang, Hui, Stephan Baader, Michael K Sixt, Joachim Kappler, and Uwe Rauch.
“Neurocan-GFP Fusion Protein: A New Approach to Detect Hyaluronan on Tissue Sections
and Living Cells.” Journal of Histochemistry and Cytochemistry. Histochemical
Society, 2004. https://doi.org/10.1369/jhc.3A6221.2004.'
ieee: 'H. Zhang, S. Baader, M. K. Sixt, J. Kappler, and U. Rauch, “Neurocan-GFP
fusion protein: a new approach to detect hyaluronan on tissue sections and living
cells,” Journal of Histochemistry and Cytochemistry, vol. 52, no. 7. Histochemical
Society, pp. 915–922, 2004.'
ista: 'Zhang H, Baader S, Sixt MK, Kappler J, Rauch U. 2004. Neurocan-GFP fusion
protein: a new approach to detect hyaluronan on tissue sections and living cells.
Journal of Histochemistry and Cytochemistry. 52(7), 915–922.'
mla: 'Zhang, Hui, et al. “Neurocan-GFP Fusion Protein: A New Approach to Detect
Hyaluronan on Tissue Sections and Living Cells.” Journal of Histochemistry
and Cytochemistry, vol. 52, no. 7, Histochemical Society, 2004, pp. 915–22,
doi:10.1369/jhc.3A6221.2004.'
short: H. Zhang, S. Baader, M.K. Sixt, J. Kappler, U. Rauch, Journal of Histochemistry
and Cytochemistry 52 (2004) 915–922.
date_created: 2018-12-11T12:05:57Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:53:17Z
day: '01'
doi: 10.1369/jhc.3A6221.2004
extern: 1
intvolume: ' 52'
issue: '7'
month: '01'
page: 915 - 922
publication: Journal of Histochemistry and Cytochemistry
publication_status: published
publisher: Histochemical Society
publist_id: '2196'
quality_controlled: 0
status: public
title: 'Neurocan-GFP fusion protein: a new approach to detect hyaluronan on tissue
sections and living cells'
type: journal_article
volume: 52
year: '2004'
...
---
_id: '3984'
abstract:
- lang: eng
text: We combine topological and geometric methods to construct a multiresolution
representation for a function over a two-dimensional domain. In a preprocessing
stage, we create the Morse-Smale complex of the function and progressively simplify
its topology by cancelling pairs of critical points. Based on a simple notion
of dependency among these cancellations, we construct a hierarchical data structure
supporting traversal and reconstruction operations similarly to traditional geometry-based
representations. We use this data structure to extract topologically valid approximations
that satisfy error bounds provided at runtime.
author:
- first_name: Peer
full_name: Bremer, Peer-Timo
last_name: Bremer
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Bernd
full_name: Hamann, Bernd
last_name: Hamann
- first_name: Valerio
full_name: Pascucci, Valerio
last_name: Pascucci
citation:
ama: Bremer P, Edelsbrunner H, Hamann B, Pascucci V. A topological hierarchy for
functions on triangulated surfaces. IEEE Transactions on Visualization and
Computer Graphics. 2004;10(4):385-396. doi:10.1109/TVCG.2004.3
apa: Bremer, P., Edelsbrunner, H., Hamann, B., & Pascucci, V. (2004). A topological
hierarchy for functions on triangulated surfaces. IEEE Transactions on Visualization
and Computer Graphics. IEEE. https://doi.org/10.1109/TVCG.2004.3
chicago: Bremer, Peer, Herbert Edelsbrunner, Bernd Hamann, and Valerio Pascucci.
“A Topological Hierarchy for Functions on Triangulated Surfaces.” IEEE Transactions
on Visualization and Computer Graphics. IEEE, 2004. https://doi.org/10.1109/TVCG.2004.3.
ieee: P. Bremer, H. Edelsbrunner, B. Hamann, and V. Pascucci, “A topological hierarchy
for functions on triangulated surfaces,” IEEE Transactions on Visualization
and Computer Graphics, vol. 10, no. 4. IEEE, pp. 385–396, 2004.
ista: Bremer P, Edelsbrunner H, Hamann B, Pascucci V. 2004. A topological hierarchy
for functions on triangulated surfaces. IEEE Transactions on Visualization and
Computer Graphics. 10(4), 385–396.
mla: Bremer, Peer, et al. “A Topological Hierarchy for Functions on Triangulated
Surfaces.” IEEE Transactions on Visualization and Computer Graphics, vol.
10, no. 4, IEEE, 2004, pp. 385–96, doi:10.1109/TVCG.2004.3.
short: P. Bremer, H. Edelsbrunner, B. Hamann, V. Pascucci, IEEE Transactions on
Visualization and Computer Graphics 10 (2004) 385–396.
date_created: 2018-12-11T12:06:16Z
date_published: 2004-07-01T00:00:00Z
date_updated: 2021-01-12T07:53:39Z
day: '01'
doi: 10.1109/TVCG.2004.3
extern: 1
intvolume: ' 10'
issue: '4'
month: '07'
page: 385 - 396
publication: IEEE Transactions on Visualization and Computer Graphics
publication_status: published
publisher: IEEE
publist_id: '2139'
quality_controlled: 0
status: public
title: A topological hierarchy for functions on triangulated surfaces
type: journal_article
volume: 10
year: '2004'
...
---
_id: '3985'
abstract:
- lang: eng
text: Given a Morse function f over a 2-manifold with or without boundary, the Reeb
graph is obtained by contracting the connected components of the level sets to
points. We prove tight upper and lower bounds on the number of loops in the Reeb
graph that depend on the genus, the number of boundary components, and whether
or not the 2-manifold is orientable. We also give an algorithm that constructs
the Reeb graph in time O(n log n), where n is the number of edges in the triangulation
used to represent the 2-manifold and the Morse function.
acknowledgement: Partially supported by NSF under Grants EIA-99-72879 and CCR-00-86013.
author:
- first_name: Kree
full_name: Cole-McLaughlin, Kree
last_name: Cole Mclaughlin
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Harer, John
last_name: Harer
- first_name: Vijay
full_name: Natarajan, Vijay
last_name: Natarajan
- first_name: Valerio
full_name: Pascucci, Valerio
last_name: Pascucci
citation:
ama: Cole Mclaughlin K, Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Loops
in Reeb graphs of 2-manifolds. Discrete & Computational Geometry. 2004;32(2):231-244.
doi:10.1007/s00454-004-1122-6
apa: Cole Mclaughlin, K., Edelsbrunner, H., Harer, J., Natarajan, V., & Pascucci,
V. (2004). Loops in Reeb graphs of 2-manifolds. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/s00454-004-1122-6
chicago: Cole Mclaughlin, Kree, Herbert Edelsbrunner, John Harer, Vijay Natarajan,
and Valerio Pascucci. “Loops in Reeb Graphs of 2-Manifolds.” Discrete &
Computational Geometry. Springer, 2004. https://doi.org/10.1007/s00454-004-1122-6.
ieee: K. Cole Mclaughlin, H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci,
“Loops in Reeb graphs of 2-manifolds,” Discrete & Computational Geometry,
vol. 32, no. 2. Springer, pp. 231–244, 2004.
ista: Cole Mclaughlin K, Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2004.
Loops in Reeb graphs of 2-manifolds. Discrete & Computational Geometry. 32(2),
231–244.
mla: Cole Mclaughlin, Kree, et al. “Loops in Reeb Graphs of 2-Manifolds.” Discrete
& Computational Geometry, vol. 32, no. 2, Springer, 2004, pp. 231–44,
doi:10.1007/s00454-004-1122-6.
short: K. Cole Mclaughlin, H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci,
Discrete & Computational Geometry 32 (2004) 231–244.
date_created: 2018-12-11T12:06:16Z
date_published: 2004-07-01T00:00:00Z
date_updated: 2021-01-12T07:53:39Z
day: '01'
doi: 10.1007/s00454-004-1122-6
extern: 1
intvolume: ' 32'
issue: '2'
month: '07'
page: 231 - 244
publication: Discrete & Computational Geometry
publication_status: published
publisher: Springer
publist_id: '2140'
quality_controlled: 0
status: public
title: Loops in Reeb graphs of 2-manifolds
type: journal_article
volume: 32
year: '2004'
...
---
_id: '3986'
abstract:
- lang: eng
text: The motion of a biomolecule greatly depends on the engulfing solution, which
is mostly water. Instead of representing individual water molecules, it is desirable
to develop implicit solvent models that nevertheless accurately represent the
contribution of the solvent interaction to the motion. In such models, hydrophobicity
is expressed as a weighted sum of atomic surface areas. The derivatives of these
weighted areas contribute to the force that drives the motion. In this paper we
give formulas for the weighted and unweighted area derivatives of a molecule modeled
as a space-filling diagram made up of balls in motion. Other than the radii and
the centers of the balls, the formulas are given in terms of the sizes of circular
arcs of the boundary and edges of the power diagram. We also give inclusion-exclusion
formulas for these sizes.
acknowledgement: Partially supported by NSF under grant CCR-00-86013 and NSF under
grant CCR-97-12088.
author:
- first_name: Robert
full_name: Bryant, Robert
last_name: Bryant
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Patrice
full_name: Koehl, Patrice
last_name: Koehl
- first_name: Michael
full_name: Levitt, Michael
last_name: Levitt
citation:
ama: Bryant R, Edelsbrunner H, Koehl P, Levitt M. The area derivative of a space-filling
diagram. Discrete & Computational Geometry. 2004;32(3):293-308. doi:10.1007/s00454-004-1099-1
apa: Bryant, R., Edelsbrunner, H., Koehl, P., & Levitt, M. (2004). The area
derivative of a space-filling diagram. Discrete & Computational Geometry.
Springer. https://doi.org/10.1007/s00454-004-1099-1
chicago: Bryant, Robert, Herbert Edelsbrunner, Patrice Koehl, and Michael Levitt.
“The Area Derivative of a Space-Filling Diagram.” Discrete & Computational
Geometry. Springer, 2004. https://doi.org/10.1007/s00454-004-1099-1.
ieee: R. Bryant, H. Edelsbrunner, P. Koehl, and M. Levitt, “The area derivative
of a space-filling diagram,” Discrete & Computational Geometry, vol.
32, no. 3. Springer, pp. 293–308, 2004.
ista: Bryant R, Edelsbrunner H, Koehl P, Levitt M. 2004. The area derivative of
a space-filling diagram. Discrete & Computational Geometry. 32(3), 293–308.
mla: Bryant, Robert, et al. “The Area Derivative of a Space-Filling Diagram.” Discrete
& Computational Geometry, vol. 32, no. 3, Springer, 2004, pp. 293–308,
doi:10.1007/s00454-004-1099-1.
short: R. Bryant, H. Edelsbrunner, P. Koehl, M. Levitt, Discrete & Computational
Geometry 32 (2004) 293–308.
date_created: 2018-12-11T12:06:17Z
date_published: 2004-09-01T00:00:00Z
date_updated: 2021-01-12T07:53:40Z
day: '01'
doi: 10.1007/s00454-004-1099-1
extern: 1
intvolume: ' 32'
issue: '3'
month: '09'
page: 293 - 308
publication: Discrete & Computational Geometry
publication_status: published
publisher: Springer
publist_id: '2141'
quality_controlled: 0
status: public
title: The area derivative of a space-filling diagram
type: journal_article
volume: 32
year: '2004'
...
---
_id: '3987'
abstract:
- lang: eng
text: 'We consider scientific data sets that describe density functions over three-dimensional
geometric domains. Such data sets are often large and coarsened representations
are needed for visualization and analysis. Assuming a tetrahedral mesh representation,
we construct such representations with a simplification algorithm that combines
three goals: the approximation of the function, the preservation of the mesh topology,
and the improvement of the mesh quality. The third goal is achieved with a novel
extension of the well-known quadric error metric. We perform a number of computational
experiments to understand the effect of mesh quality improvement on the density
map approximation. In addition, we study the effect of geometric simplification
on the topological features of the function by monitoring its critical points.'
author:
- first_name: Vijay
full_name: Natarajan, Vijay
last_name: Natarajan
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Natarajan V, Edelsbrunner H. Simplification of three-dimensional density maps.
IEEE Transactions on Visualization and Computer Graphics. 2004;10(5):587-597.
doi:10.1109/TVCG.2004.32
apa: Natarajan, V., & Edelsbrunner, H. (2004). Simplification of three-dimensional
density maps. IEEE Transactions on Visualization and Computer Graphics.
IEEE. https://doi.org/10.1109/TVCG.2004.32
chicago: Natarajan, Vijay, and Herbert Edelsbrunner. “Simplification of Three-Dimensional
Density Maps.” IEEE Transactions on Visualization and Computer Graphics.
IEEE, 2004. https://doi.org/10.1109/TVCG.2004.32.
ieee: V. Natarajan and H. Edelsbrunner, “Simplification of three-dimensional density
maps,” IEEE Transactions on Visualization and Computer Graphics, vol. 10,
no. 5. IEEE, pp. 587–597, 2004.
ista: Natarajan V, Edelsbrunner H. 2004. Simplification of three-dimensional density
maps. IEEE Transactions on Visualization and Computer Graphics. 10(5), 587–597.
mla: Natarajan, Vijay, and Herbert Edelsbrunner. “Simplification of Three-Dimensional
Density Maps.” IEEE Transactions on Visualization and Computer Graphics,
vol. 10, no. 5, IEEE, 2004, pp. 587–97, doi:10.1109/TVCG.2004.32.
short: V. Natarajan, H. Edelsbrunner, IEEE Transactions on Visualization and Computer
Graphics 10 (2004) 587–597.
date_created: 2018-12-11T12:06:17Z
date_published: 2004-07-12T00:00:00Z
date_updated: 2021-01-12T07:53:40Z
day: '12'
doi: 10.1109/TVCG.2004.32
extern: 1
intvolume: ' 10'
issue: '5'
month: '07'
page: 587 - 597
publication: IEEE Transactions on Visualization and Computer Graphics
publication_status: published
publisher: IEEE
publist_id: '2142'
quality_controlled: 0
status: public
title: Simplification of three-dimensional density maps
type: journal_article
volume: 10
year: '2004'
...
---
_id: '3988'
abstract:
- lang: eng
text: We give an algorithm that locally improves the fit between two proteins modeled
as space-filling diagrams. The algorithm defines the fit in purely geometric terms
and improves by applying a rigid motion to one of the two proteins. Our implementation
of the algorithm takes between three and ten seconds and converges with high likelihood
to the correct docked configuration, provided it starts at a position away from
the correct one by at most 18 degrees of rotation and at most 3.0Angstrom of translation.
The speed and convergence radius make this an attractive algorithm to use in combination
with a coarse sampling of the six-dimensional space of rigid motions.
acknowledgement: Supported by NSF under grant CCR-00-86013, BGT Postdoc Program from
Duke University and NIH under grant R01 GM61822-01.
alternative_title:
- LNCS
author:
- first_name: Vicky
full_name: Choi, Vicky
last_name: Choi
- first_name: Pankaj
full_name: Agarwal, Pankaj K
last_name: Agarwal
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Johannes
full_name: Rudolph, Johannes
last_name: Rudolph
citation:
ama: 'Choi V, Agarwal P, Edelsbrunner H, Rudolph J. Local search heuristic for rigid
protein docking. In: Vol 3240. Springer; 2004:218-229. doi:10.1007/978-3-540-30219-3_19'
apa: 'Choi, V., Agarwal, P., Edelsbrunner, H., & Rudolph, J. (2004). Local search
heuristic for rigid protein docking (Vol. 3240, pp. 218–229). Presented at the
WABI: 4th International Workshop on Algorithms in Bioinformatics, Springer. https://doi.org/10.1007/978-3-540-30219-3_19'
chicago: Choi, Vicky, Pankaj Agarwal, Herbert Edelsbrunner, and Johannes Rudolph.
“Local Search Heuristic for Rigid Protein Docking,” 3240:218–29. Springer, 2004.
https://doi.org/10.1007/978-3-540-30219-3_19.
ieee: 'V. Choi, P. Agarwal, H. Edelsbrunner, and J. Rudolph, “Local search heuristic
for rigid protein docking,” presented at the WABI: 4th International Workshop
on Algorithms in Bioinformatics, 2004, vol. 3240, pp. 218–229.'
ista: 'Choi V, Agarwal P, Edelsbrunner H, Rudolph J. 2004. Local search heuristic
for rigid protein docking. WABI: 4th International Workshop on Algorithms in Bioinformatics,
LNCS, vol. 3240, 218–229.'
mla: Choi, Vicky, et al. Local Search Heuristic for Rigid Protein Docking.
Vol. 3240, Springer, 2004, pp. 218–29, doi:10.1007/978-3-540-30219-3_19.
short: V. Choi, P. Agarwal, H. Edelsbrunner, J. Rudolph, in:, Springer, 2004, pp.
218–229.
conference:
name: 'WABI: 4th International Workshop on Algorithms in Bioinformatics'
date_created: 2018-12-11T12:06:17Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:53:41Z
day: '01'
doi: 10.1007/978-3-540-30219-3_19
extern: 1
intvolume: ' 3240'
month: '01'
page: 218 - 229
publication_status: published
publisher: Springer
publist_id: '2136'
quality_controlled: 0
status: public
title: Local search heuristic for rigid protein docking
type: conference
volume: 3240
year: '2004'
...
---
_id: '3989'
abstract:
- lang: eng
text: We introduce local and global comparison measures for a collection of k less
than or equal to d real-valued smooth functions on a common d-dimensional Riemannian
manifold. For k = d = 2 we relate the measures to the set of critical points of
one function restricted to the level sets of the other. The definition of the
measures extends to piecewise linear functions for which they ace easy to compute.
The computation of the measures forms the centerpiece of a software tool which
we use to study scientific datasets.
author:
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Harer, John
last_name: Harer
- first_name: Vijay
full_name: Natarajan, Vijay
last_name: Natarajan
- first_name: Valerio
full_name: Pascucci, Valerio
last_name: Pascucci
citation:
ama: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. Local and global comparison
of continuous functions. In: IEEE; 2004:275-280. doi:10.1109/VISUAL.2004.68'
apa: 'Edelsbrunner, H., Harer, J., Natarajan, V., & Pascucci, V. (2004). Local
and global comparison of continuous functions (pp. 275–280). Presented at the
VIS: IEEE Visualization, IEEE. https://doi.org/10.1109/VISUAL.2004.68'
chicago: Edelsbrunner, Herbert, John Harer, Vijay Natarajan, and Valerio Pascucci.
“Local and Global Comparison of Continuous Functions,” 275–80. IEEE, 2004. https://doi.org/10.1109/VISUAL.2004.68.
ieee: 'H. Edelsbrunner, J. Harer, V. Natarajan, and V. Pascucci, “Local and global
comparison of continuous functions,” presented at the VIS: IEEE Visualization,
2004, pp. 275–280.'
ista: 'Edelsbrunner H, Harer J, Natarajan V, Pascucci V. 2004. Local and global
comparison of continuous functions. VIS: IEEE Visualization, 275–280.'
mla: Edelsbrunner, Herbert, et al. Local and Global Comparison of Continuous
Functions. IEEE, 2004, pp. 275–80, doi:10.1109/VISUAL.2004.68.
short: H. Edelsbrunner, J. Harer, V. Natarajan, V. Pascucci, in:, IEEE, 2004, pp.
275–280.
conference:
name: 'VIS: IEEE Visualization'
date_created: 2018-12-11T12:06:18Z
date_published: 2004-10-01T00:00:00Z
date_updated: 2021-01-12T07:53:41Z
day: '01'
doi: 10.1109/VISUAL.2004.68
extern: 1
month: '10'
page: 275 - 280
publication_status: published
publisher: IEEE
publist_id: '2137'
quality_controlled: 0
status: public
title: Local and global comparison of continuous functions
type: conference
year: '2004'
...