---
_id: '1464'
abstract:
- lang: eng
text: "The moduli space of stable vector bundles on a Riemann surface is smooth
when the rank and degree are coprime, and is diffeomorphic to the space of unitary
connections of central constant curvature. A classic result of Newstead and Atiyah
and Bott asserts that its rational cohomology ring is generated by the universal
classes, that is, by the Kunneth components of the Chern classes of the universal
bundle.\n\nThis paper studies the larger, non-compact moduli space of Higgs bundles,
as introduced by Hitchin and Simpson, with values in the canonical bundle K. This
is diffeomorphic to the space of all connections of central constant curvature,
whether unitary or not. The main result of the paper is that, in the rank 2 case,
the rational cohomology ring of this space is again generated by universal classes.\n\nThe
spaces of Higgs bundles with values in K(n) for n > 0 turn out to be essential
to the story. Indeed, we show that their direct limit has the homotopy type of
the classifying space of the gauge group, and hence has cohomology generated by
universal classes. 2000 Mathematics Subject Classification 14H60 (primary), 14D20,
14H81, 32Q55, 58D27 (secondary). "
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Michael
full_name: Thaddeus, Michael
last_name: Thaddeus
citation:
ama: Hausel T, Thaddeus M. Generators for the cohomology ring of the moduli space
of rank 2 higgs bundles. Proceedings of the London Mathematical Society.
2004;88(3):632-658. doi:10.1112/S0024611503014618
apa: Hausel, T., & Thaddeus, M. (2004). Generators for the cohomology ring of
the moduli space of rank 2 higgs bundles. Proceedings of the London Mathematical
Society. Oxford University Press. https://doi.org/10.1112/S0024611503014618
chicago: Hausel, Tamás, and Michael Thaddeus. “Generators for the Cohomology Ring
of the Moduli Space of Rank 2 Higgs Bundles.” Proceedings of the London Mathematical
Society. Oxford University Press, 2004. https://doi.org/10.1112/S0024611503014618.
ieee: T. Hausel and M. Thaddeus, “Generators for the cohomology ring of the moduli
space of rank 2 higgs bundles,” Proceedings of the London Mathematical Society,
vol. 88, no. 3. Oxford University Press, pp. 632–658, 2004.
ista: Hausel T, Thaddeus M. 2004. Generators for the cohomology ring of the moduli
space of rank 2 higgs bundles. Proceedings of the London Mathematical Society.
88(3), 632–658.
mla: Hausel, Tamás, and Michael Thaddeus. “Generators for the Cohomology Ring of
the Moduli Space of Rank 2 Higgs Bundles.” Proceedings of the London Mathematical
Society, vol. 88, no. 3, Oxford University Press, 2004, pp. 632–58, doi:10.1112/S0024611503014618.
short: T. Hausel, M. Thaddeus, Proceedings of the London Mathematical Society 88
(2004) 632–658.
date_created: 2018-12-11T11:52:10Z
date_published: 2004-05-01T00:00:00Z
date_updated: 2021-01-12T06:50:55Z
day: '01'
doi: 10.1112/S0024611503014618
extern: 1
intvolume: ' 88'
issue: '3'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/0003093
month: '05'
oa: 1
page: 632 - 658
publication: Proceedings of the London Mathematical Society
publication_status: published
publisher: Oxford University Press
publist_id: '5736'
quality_controlled: 0
status: public
title: Generators for the cohomology ring of the moduli space of rank 2 higgs bundles
type: journal_article
volume: 88
year: '2004'
...
---
_id: '13434'
abstract:
- lang: eng
text: Thin films of ionically doped gelatin have been color-patterned with submicrometer
precision using the wet-stamping technique. Inorganic salts are delivered onto
the gelatin surface from an agarose stamp, and diffuse into the gelatine layer,
producting deeply colored precipitates. Reaction fronts originating from different
features of the stamp cease within < 1 μm of each other, leaving sharp, transparent
regions in between.
article_processing_charge: No
article_type: original
author:
- first_name: C. J.
full_name: Campbell, C. J.
last_name: Campbell
- first_name: M.
full_name: Fialkowski, M.
last_name: Fialkowski
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: I. T.
full_name: Bensemann, I. T.
last_name: Bensemann
- first_name: B. A.
full_name: Grzybowski, B. A.
last_name: Grzybowski
citation:
ama: Campbell CJ, Fialkowski M, Klajn R, Bensemann IT, Grzybowski BA. Color micro-
and nanopatterning with counter-propagating reaction-diffusion fronts. Advanced
Materials. 2004;16(21):1912-1917. doi:10.1002/adma.200400383
apa: Campbell, C. J., Fialkowski, M., Klajn, R., Bensemann, I. T., & Grzybowski,
B. A. (2004). Color micro- and nanopatterning with counter-propagating reaction-diffusion
fronts. Advanced Materials. Wiley. https://doi.org/10.1002/adma.200400383
chicago: Campbell, C. J., M. Fialkowski, Rafal Klajn, I. T. Bensemann, and B. A.
Grzybowski. “Color Micro- and Nanopatterning with Counter-Propagating Reaction-Diffusion
Fronts.” Advanced Materials. Wiley, 2004. https://doi.org/10.1002/adma.200400383.
ieee: C. J. Campbell, M. Fialkowski, R. Klajn, I. T. Bensemann, and B. A. Grzybowski,
“Color micro- and nanopatterning with counter-propagating reaction-diffusion fronts,”
Advanced Materials, vol. 16, no. 21. Wiley, pp. 1912–1917, 2004.
ista: Campbell CJ, Fialkowski M, Klajn R, Bensemann IT, Grzybowski BA. 2004. Color
micro- and nanopatterning with counter-propagating reaction-diffusion fronts.
Advanced Materials. 16(21), 1912–1917.
mla: Campbell, C. J., et al. “Color Micro- and Nanopatterning with Counter-Propagating
Reaction-Diffusion Fronts.” Advanced Materials, vol. 16, no. 21, Wiley,
2004, pp. 1912–17, doi:10.1002/adma.200400383.
short: C.J. Campbell, M. Fialkowski, R. Klajn, I.T. Bensemann, B.A. Grzybowski,
Advanced Materials 16 (2004) 1912–1917.
date_created: 2023-08-01T10:39:09Z
date_published: 2004-11-14T00:00:00Z
date_updated: 2023-08-08T12:41:23Z
day: '14'
doi: 10.1002/adma.200400383
extern: '1'
intvolume: ' 16'
issue: '21'
keyword:
- Mechanical Engineering
- Mechanics of Materials
- General Materials Science
language:
- iso: eng
month: '11'
oa_version: None
page: 1912-1917
publication: Advanced Materials
publication_identifier:
eissn:
- 1521-4095
issn:
- 0935-9648
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Color micro- and nanopatterning with counter-propagating reaction-diffusion
fronts
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2004'
...
---
_id: '13435'
abstract:
- lang: eng
text: Micropatterning of surfaces with several chemicals at different spatial locations
usually requires multiple stamping and registration steps. Here, we describe an
experimental method based on reaction–diffusion phenomena that allows for simultaneous
micropatterning of a substrate with several coloured chemicals. In this method,
called wet stamping (WETS), aqueous solutions of two or more inorganic salts are
delivered onto a film of dry, ionically doped gelatin from an agarose stamp patterned
in bas relief. Once in conformal contact, these salts diffuse into the gelatin,
where they react to give deeply coloured precipitates. Separation of colours in
the plane of the surface is the consequence of the differences in the diffusion
coefficients, the solubility products, and the amounts of different salts delivered
from the stamp, and is faithfully reproduced by a theoretical model based on a
system of reaction–diffusion partial differential equations. The multicolour micropatterns
are useful as non-binary optical elements, and could potentially form the basis
of new applications in microseparations and in controlled delivery.
article_processing_charge: No
article_type: original
author:
- first_name: Rafal
full_name: Klajn, Rafal
id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
last_name: Klajn
- first_name: Marcin
full_name: Fialkowski, Marcin
last_name: Fialkowski
- first_name: Igor T.
full_name: Bensemann, Igor T.
last_name: Bensemann
- first_name: Agnieszka
full_name: Bitner, Agnieszka
last_name: Bitner
- first_name: C. J.
full_name: Campbell, C. J.
last_name: Campbell
- first_name: Kyle
full_name: Bishop, Kyle
last_name: Bishop
- first_name: Stoyan
full_name: Smoukov, Stoyan
last_name: Smoukov
- first_name: Bartosz A.
full_name: Grzybowski, Bartosz A.
last_name: Grzybowski
citation:
ama: Klajn R, Fialkowski M, Bensemann IT, et al. Multicolour micropatterning of
thin films of dry gels. Nature Materials. 2004;3:729-735. doi:10.1038/nmat1231
apa: Klajn, R., Fialkowski, M., Bensemann, I. T., Bitner, A., Campbell, C. J., Bishop,
K., … Grzybowski, B. A. (2004). Multicolour micropatterning of thin films of dry
gels. Nature Materials. Springer Nature. https://doi.org/10.1038/nmat1231
chicago: Klajn, Rafal, Marcin Fialkowski, Igor T. Bensemann, Agnieszka Bitner, C.
J. Campbell, Kyle Bishop, Stoyan Smoukov, and Bartosz A. Grzybowski. “Multicolour
Micropatterning of Thin Films of Dry Gels.” Nature Materials. Springer
Nature, 2004. https://doi.org/10.1038/nmat1231.
ieee: R. Klajn et al., “Multicolour micropatterning of thin films of dry
gels,” Nature Materials, vol. 3. Springer Nature, pp. 729–735, 2004.
ista: Klajn R, Fialkowski M, Bensemann IT, Bitner A, Campbell CJ, Bishop K, Smoukov
S, Grzybowski BA. 2004. Multicolour micropatterning of thin films of dry gels.
Nature Materials. 3, 729–735.
mla: Klajn, Rafal, et al. “Multicolour Micropatterning of Thin Films of Dry Gels.”
Nature Materials, vol. 3, Springer Nature, 2004, pp. 729–35, doi:10.1038/nmat1231.
short: R. Klajn, M. Fialkowski, I.T. Bensemann, A. Bitner, C.J. Campbell, K. Bishop,
S. Smoukov, B.A. Grzybowski, Nature Materials 3 (2004) 729–735.
date_created: 2023-08-01T10:39:23Z
date_published: 2004-09-19T00:00:00Z
date_updated: 2023-08-08T12:42:51Z
day: '19'
doi: 10.1038/nmat1231
extern: '1'
external_id:
pmid:
- '15378052'
intvolume: ' 3'
keyword:
- Mechanical Engineering
- Mechanics of Materials
- Condensed Matter Physics
- General Materials Science
- General Chemistry
language:
- iso: eng
month: '09'
oa_version: None
page: 729-735
pmid: 1
publication: Nature Materials
publication_identifier:
eissn:
- 1476-4660
issn:
- 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multicolour micropatterning of thin films of dry gels
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2004'
...
---
_id: '902'
abstract:
- lang: eng
text: 'We compare the functional spectrum of protein evolution in two separate animal
lineages with respect to two hypotheses: (1) rates of divergence are distributed
similarly among functional classes within both lineages, indicating that selective
pressure on the proteome is largely independent of organismic-level biological
requirements; and (2) rates of divergence are distributed differently among functional
classes within each lineage, indicating species-specific selective regimes impact
genome-wide substitutional patterns. Integrating comparative genome sequence with
data from tissue-specific expressed-sequence-tag (EST) libraries and detailed
database annotations, we find a functional genomic signature of rapid evolution
and selective constraint shared between mammalian and nematode lineages despite
their extensive morphological and ecological differences and distant common ancestry.
In both phyla, we find evidence of accelerated evolution among components of molecular
systems involved in coevolutionary change. In mammals, lineage-specific fast evolving
genes include those involved in reproduction, immunity, and possibly, maternal-fetal
conflict. Likelihood ratio tests provide evidence for positive selection in these
rapidly evolving functional categories in mammals. In contrast, slowly evolving
genes, in terms of amino acid or insertion/deletion (indel) change, in both phyla
are involved in core molecular processes such as transcription, translation, and
protein transport. Thus, strong purifying selection appears to act on the same
core cellular processes in both mammalian and nematode lineages, whereas positive
and/or relaxed selection acts on different biological processes in each lineage.'
acknowledgement: |-
We thank all members of the Hartl lab for their friendly support and Guillaume Achaz for valuable comments. We also thank the Sanger Institute and the Genome Sequencing Center at Wash- ington University, St. Louis and Lincoln Stein for providing un- finished C. briggsae sequence. Special thanks to the Bauer Center for Genomics Research at Harvard University and Gordon Kindl- mann at the University of Utah Scientific Computing and Imag- ing Institute for computational resources. R.J.K. is financially supported by a postdoctoral fellowship from the Natural Sciences and Engineering Research Council of Canada.
The publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.
author:
- first_name: Cristian
full_name: Castillo-Davis, Cristian I
last_name: Castillo Davis
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Daniel
full_name: Hartl, Daniel L
last_name: Hartl
- first_name: Rob
full_name: Kulathinal, Rob J
last_name: Kulathinal
citation:
ama: 'Castillo Davis C, Kondrashov F, Hartl D, Kulathinal R. The functional genomic
distribution of protein divergence in two animal phyla: Coevolution, genomic conflict,
and constraint. Genome Research. 2004;14(5):802-811. doi:10.1101/gr.2195604'
apa: 'Castillo Davis, C., Kondrashov, F., Hartl, D., & Kulathinal, R. (2004).
The functional genomic distribution of protein divergence in two animal phyla:
Coevolution, genomic conflict, and constraint. Genome Research. Cold Spring
Harbor Laboratory Press. https://doi.org/10.1101/gr.2195604'
chicago: 'Castillo Davis, Cristian, Fyodor Kondrashov, Daniel Hartl, and Rob Kulathinal.
“The Functional Genomic Distribution of Protein Divergence in Two Animal Phyla:
Coevolution, Genomic Conflict, and Constraint.” Genome Research. Cold Spring
Harbor Laboratory Press, 2004. https://doi.org/10.1101/gr.2195604.'
ieee: 'C. Castillo Davis, F. Kondrashov, D. Hartl, and R. Kulathinal, “The functional
genomic distribution of protein divergence in two animal phyla: Coevolution, genomic
conflict, and constraint,” Genome Research, vol. 14, no. 5. Cold Spring
Harbor Laboratory Press, pp. 802–811, 2004.'
ista: 'Castillo Davis C, Kondrashov F, Hartl D, Kulathinal R. 2004. The functional
genomic distribution of protein divergence in two animal phyla: Coevolution, genomic
conflict, and constraint. Genome Research. 14(5), 802–811.'
mla: 'Castillo Davis, Cristian, et al. “The Functional Genomic Distribution of Protein
Divergence in Two Animal Phyla: Coevolution, Genomic Conflict, and Constraint.”
Genome Research, vol. 14, no. 5, Cold Spring Harbor Laboratory Press, 2004,
pp. 802–11, doi:10.1101/gr.2195604.'
short: C. Castillo Davis, F. Kondrashov, D. Hartl, R. Kulathinal, Genome Research
14 (2004) 802–811.
date_created: 2018-12-11T11:49:06Z
date_published: 2004-05-01T00:00:00Z
date_updated: 2021-01-12T08:21:47Z
day: '01'
doi: 10.1101/gr.2195604
extern: 1
intvolume: ' 14'
issue: '5'
month: '05'
page: 802 - 811
publication: Genome Research
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '6750'
quality_controlled: 0
status: public
title: 'The functional genomic distribution of protein divergence in two animal phyla:
Coevolution, genomic conflict, and constraint'
type: journal_article
volume: 14
year: '2004'
...
---
_id: '9454'
article_processing_charge: No
article_type: original
author:
- first_name: Simon W.-L.
full_name: Chan, Simon W.-L.
last_name: Chan
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: ' Zhixin'
full_name: Xie, Zhixin
last_name: Xie
- first_name: ' Lisa K.'
full_name: Johansen, Lisa K.
last_name: Johansen
- first_name: James C.
full_name: Carrington, James C.
last_name: Carrington
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Chan SW-L, Zilberman D, Xie Zhixin, Johansen Lisa K., Carrington JC, Jacobsen
SE. RNA silencing genes control de novo DNA methylation. Science. 2004;303(5662):1336.
doi:10.1126/science.1095989
apa: Chan, S. W.-L., Zilberman, D., Xie, Zhixin, Johansen, Lisa K., Carrington,
J. C., & Jacobsen, S. E. (2004). RNA silencing genes control de novo DNA methylation.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1095989
chicago: Chan, Simon W.-L., Daniel Zilberman, Zhixin Xie, Lisa K. Johansen, James
C. Carrington, and Steven E. Jacobsen. “RNA Silencing Genes Control de Novo DNA
Methylation.” Science. American Association for the Advancement of Science,
2004. https://doi.org/10.1126/science.1095989.
ieee: S. W.-L. Chan, D. Zilberman, Zhixin Xie, Lisa K. Johansen, J. C. Carrington,
and S. E. Jacobsen, “RNA silencing genes control de novo DNA methylation,” Science,
vol. 303, no. 5662. American Association for the Advancement of Science, p. 1336,
2004.
ista: Chan SW-L, Zilberman D, Xie Zhixin, Johansen Lisa K., Carrington JC, Jacobsen
SE. 2004. RNA silencing genes control de novo DNA methylation. Science. 303(5662),
1336.
mla: Chan, Simon W. L., et al. “RNA Silencing Genes Control de Novo DNA Methylation.”
Science, vol. 303, no. 5662, American Association for the Advancement of
Science, 2004, p. 1336, doi:10.1126/science.1095989.
short: S.W.-L. Chan, D. Zilberman, Zhixin Xie, Lisa K. Johansen, J.C. Carrington,
S.E. Jacobsen, Science 303 (2004) 1336.
date_created: 2021-06-04T11:12:35Z
date_published: 2004-02-27T00:00:00Z
date_updated: 2021-12-14T09:13:53Z
day: '27'
department:
- _id: DaZi
doi: 10.1126/science.1095989
extern: '1'
external_id:
pmid:
- '14988555'
intvolume: ' 303'
issue: '5662'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '02'
oa_version: None
page: '1336'
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: RNA silencing genes control de novo DNA methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 303
year: '2004'
...
---
_id: '9493'
abstract:
- lang: eng
text: In a number of organisms, transgenes containing transcribed inverted repeats
(IRs) that produce hairpin RNA can trigger RNA-mediated silencing, which is associated
with 21-24 nucleotide small interfering RNAs (siRNAs). In plants, IR-driven RNA
silencing also causes extensive cytosine methylation of homologous DNA in both
the transgene "trigger" and any other homologous DNA sequences--"targets". Endogenous
genomic sequences, including transposable elements and repeated elements, are
also subject to RNA-mediated silencing. The RNA silencing gene ARGONAUTE4 (AGO4)
is required for maintenance of DNA methylation at several endogenous loci and
for the establishment of methylation at the FWA gene. Here, we show that mutation
of AGO4 substantially reduces the maintenance of DNA methylation triggered by
IR transgenes, but AGO4 loss-of-function does not block the initiation of DNA
methylation by IRs. AGO4 primarily affects non-CG methylation of the target sequences,
while the IR trigger sequences lose methylation in all sequence contexts. Finally,
we find that AGO4 and the DRM methyltransferase genes are required for maintenance
of siRNAs at a subset of endogenous sequences, but AGO4 is not required for the
accumulation of IR-induced siRNAs or a number of endogenous siRNAs, suggesting
that AGO4 may function downstream of siRNA production.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Xiaofeng
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: Lisa K.
full_name: Johansen, Lisa K.
last_name: Johansen
- first_name: Zhixin
full_name: Xie, Zhixin
last_name: Xie
- first_name: James C.
full_name: Carrington, James C.
last_name: Carrington
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Zilberman D, Cao X, Johansen LK, Xie Z, Carrington JC, Jacobsen SE. Role of
Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats.
Current Biology. 2004;14(13):1214-1220. doi:10.1016/j.cub.2004.06.055
apa: Zilberman, D., Cao, X., Johansen, L. K., Xie, Z., Carrington, J. C., &
Jacobsen, S. E. (2004). Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation
triggered by inverted repeats. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2004.06.055
chicago: Zilberman, Daniel, Xiaofeng Cao, Lisa K. Johansen, Zhixin Xie, James C.
Carrington, and Steven E. Jacobsen. “Role of Arabidopsis ARGONAUTE4 in RNA-Directed
DNA Methylation Triggered by Inverted Repeats.” Current Biology. Elsevier,
2004. https://doi.org/10.1016/j.cub.2004.06.055.
ieee: D. Zilberman, X. Cao, L. K. Johansen, Z. Xie, J. C. Carrington, and S. E.
Jacobsen, “Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered
by inverted repeats,” Current Biology, vol. 14, no. 13. Elsevier, pp. 1214–1220,
2004.
ista: Zilberman D, Cao X, Johansen LK, Xie Z, Carrington JC, Jacobsen SE. 2004.
Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted
repeats. Current Biology. 14(13), 1214–1220.
mla: Zilberman, Daniel, et al. “Role of Arabidopsis ARGONAUTE4 in RNA-Directed DNA
Methylation Triggered by Inverted Repeats.” Current Biology, vol. 14, no.
13, Elsevier, 2004, pp. 1214–20, doi:10.1016/j.cub.2004.06.055.
short: D. Zilberman, X. Cao, L.K. Johansen, Z. Xie, J.C. Carrington, S.E. Jacobsen,
Current Biology 14 (2004) 1214–1220.
date_created: 2021-06-07T10:33:00Z
date_published: 2004-07-13T00:00:00Z
date_updated: 2021-12-14T08:52:00Z
day: '13'
department:
- _id: DaZi
doi: 10.1016/j.cub.2004.06.055
extern: '1'
external_id:
pmid:
- '15242620 '
intvolume: ' 14'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cub.2004.06.055
month: '07'
oa: 1
oa_version: Published Version
page: 1214-1220
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by
inverted repeats
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 14
year: '2004'
...
---
_id: '9511'
abstract:
- lang: eng
text: Recent progress in understanding the silencing of transposable elements in
the model plant Arabidopsis has revealed an interplay between DNA methylation,
histone methylation and small interfering RNAs. DNA and histone methylation are
not always sufficient to maintain silencing, and RNA-based reinforcement can be
needed to maintain as well as initiate it.
article_number: '249'
article_processing_charge: No
article_type: review
author:
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Steven
full_name: Henikoff, Steven
last_name: Henikoff
citation:
ama: 'Zilberman D, Henikoff S. Silencing of transposons in plant genomes: kick them
when they’re down. Genome Biology. 2004;5(12). doi:10.1186/gb-2004-5-12-249'
apa: 'Zilberman, D., & Henikoff, S. (2004). Silencing of transposons in plant
genomes: kick them when they’re down. Genome Biology. Springer Nature.
https://doi.org/10.1186/gb-2004-5-12-249'
chicago: 'Zilberman, Daniel, and Steven Henikoff. “Silencing of Transposons in Plant
Genomes: Kick Them When They’re Down.” Genome Biology. Springer Nature,
2004. https://doi.org/10.1186/gb-2004-5-12-249.'
ieee: 'D. Zilberman and S. Henikoff, “Silencing of transposons in plant genomes:
kick them when they’re down,” Genome Biology, vol. 5, no. 12. Springer
Nature, 2004.'
ista: 'Zilberman D, Henikoff S. 2004. Silencing of transposons in plant genomes:
kick them when they’re down. Genome Biology. 5(12), 249.'
mla: 'Zilberman, Daniel, and Steven Henikoff. “Silencing of Transposons in Plant
Genomes: Kick Them When They’re Down.” Genome Biology, vol. 5, no. 12,
249, Springer Nature, 2004, doi:10.1186/gb-2004-5-12-249.'
short: D. Zilberman, S. Henikoff, Genome Biology 5 (2004).
date_created: 2021-06-07T12:58:06Z
date_published: 2004-11-16T00:00:00Z
date_updated: 2021-12-14T08:44:24Z
day: '16'
department:
- _id: DaZi
doi: 10.1186/gb-2004-5-12-249
extern: '1'
external_id:
pmid:
- '15575975'
intvolume: ' 5'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1186/gb-2004-5-12-249
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
eissn:
- 1465-6906
issn:
- 1474-760X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Silencing of transposons in plant genomes: kick them when they''re down'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 5
year: '2004'
...
---
_id: '9517'
abstract:
- lang: eng
text: Multicellular eukaryotes produce small RNA molecules (approximately 21–24
nucleotides) of two general types, microRNA (miRNA) and short interfering RNA
(siRNA). They collectively function as sequence-specific guides to silence or
regulate genes, transposons, and viruses and to modify chromatin and genome structure.
Formation or activity of small RNAs requires factors belonging to gene families
that encode DICER (or DICER-LIKE [DCL]) and ARGONAUTE proteins and, in the case
of some siRNAs, RNA-dependent RNA polymerase (RDR) proteins. Unlike many animals,
plants encode multiple DCL and RDR proteins. Using a series of insertion mutants
of Arabidopsis thaliana, unique functions for three DCL proteins in miRNA (DCL1),
endogenous siRNA (DCL3), and viral siRNA (DCL2) biogenesis were identified. One
RDR protein (RDR2) was required for all endogenous siRNAs analyzed. The loss of
endogenous siRNA in dcl3 and rdr2 mutants was associated with loss of heterochromatic
marks and increased transcript accumulation at some loci. Defects in siRNA-generation
activity in response to turnip crinkle virus in dcl2 mutant plants correlated
with increased virus susceptibility. We conclude that proliferation and diversification
of DCL and RDR genes during evolution of plants contributed to specialization
of small RNA-directed pathways for development, chromatin structure, and defense.
article_processing_charge: No
article_type: original
author:
- first_name: Zhixin
full_name: Xie, Zhixin
last_name: Xie
- first_name: Lisa K.
full_name: Johansen, Lisa K.
last_name: Johansen
- first_name: Adam M.
full_name: Gustafson, Adam M.
last_name: Gustafson
- first_name: Kristin D.
full_name: Kasschau, Kristin D.
last_name: Kasschau
- first_name: 'Andrew D. '
full_name: 'Lellis, Andrew D. '
last_name: Lellis
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
- first_name: James C.
full_name: Carrington, James C.
last_name: Carrington
citation:
ama: Xie Z, Johansen LK, Gustafson AM, et al. Genetic and functional diversification
of small RNA pathways in plants. PLoS Biology. 2004;2(5):0642-0652. doi:10.1371/journal.pbio.0020104
apa: Xie, Z., Johansen, L. K., Gustafson, A. M., Kasschau, K. D., Lellis, A. D.,
Zilberman, D., … Carrington, J. C. (2004). Genetic and functional diversification
of small RNA pathways in plants. PLoS Biology. Public Library of Science.
https://doi.org/10.1371/journal.pbio.0020104
chicago: Xie, Zhixin, Lisa K. Johansen, Adam M. Gustafson, Kristin D. Kasschau,
Andrew D. Lellis, Daniel Zilberman, Steven E. Jacobsen, and James C. Carrington.
“Genetic and Functional Diversification of Small RNA Pathways in Plants.” PLoS
Biology. Public Library of Science, 2004. https://doi.org/10.1371/journal.pbio.0020104.
ieee: Z. Xie et al., “Genetic and functional diversification of small RNA
pathways in plants,” PLoS Biology, vol. 2, no. 5. Public Library of Science,
pp. 0642–0652, 2004.
ista: Xie Z, Johansen LK, Gustafson AM, Kasschau KD, Lellis AD, Zilberman D, Jacobsen
SE, Carrington JC. 2004. Genetic and functional diversification of small RNA pathways
in plants. PLoS Biology. 2(5), 0642–0652.
mla: Xie, Zhixin, et al. “Genetic and Functional Diversification of Small RNA Pathways
in Plants.” PLoS Biology, vol. 2, no. 5, Public Library of Science, 2004,
pp. 0642–52, doi:10.1371/journal.pbio.0020104.
short: Z. Xie, L.K. Johansen, A.M. Gustafson, K.D. Kasschau, A.D. Lellis, D. Zilberman,
S.E. Jacobsen, J.C. Carrington, PLoS Biology 2 (2004) 0642–0652.
date_created: 2021-06-07T14:12:08Z
date_published: 2004-02-24T00:00:00Z
date_updated: 2021-12-14T08:43:57Z
day: '24'
department:
- _id: DaZi
doi: 10.1371/journal.pbio.0020104
extern: '1'
external_id:
pmid:
- '15024409'
intvolume: ' 2'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1371/journal.pbio.0020104
month: '02'
oa: 1
oa_version: Published Version
page: 0642-0652
pmid: 1
publication: PLoS Biology
publication_identifier:
eissn:
- 1545-7885
issn:
- 1544-9173
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic and functional diversification of small RNA pathways in plants
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 2
year: '2004'
...
---
_id: '11800'
abstract:
- lang: eng
text: "Web search engines have emerged as one of the central applications on the
Internet. In fact, search has become one of the most important activities that
people engage in on the the Internet. Even beyond becoming the number one source
of information, a growing number of businesses are depending on web search engines
for customer acquisition.\r\n\r\nThe first generation of web search engines used
text-only retrieval techniques. Google revolutionized the field by deploying the
PageRank technology – an eigenvector-based analysis of the hyperlink structure
– to analyze the web in order to produce relevant results. Moving forward, our
goal is to achieve a better understanding of a page with a view towards producing
even more relevant results."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. The past, present, and future of web search engines. In: 31st
International Colloquium on Automata, Languages and Programming. Vol 3142.
Springer Nature; 2004:3. doi:10.1007/978-3-540-27836-8_2'
apa: 'Henzinger, M. H. (2004). The past, present, and future of web search engines.
In 31st International Colloquium on Automata, Languages and Programming
(Vol. 3142, p. 3). Turku, Finland: Springer Nature. https://doi.org/10.1007/978-3-540-27836-8_2'
chicago: Henzinger, Monika H. “The Past, Present, and Future of Web Search Engines.”
In 31st International Colloquium on Automata, Languages and Programming,
3142:3. Springer Nature, 2004. https://doi.org/10.1007/978-3-540-27836-8_2.
ieee: M. H. Henzinger, “The past, present, and future of web search engines,” in
31st International Colloquium on Automata, Languages and Programming, Turku,
Finland, 2004, vol. 3142, p. 3.
ista: 'Henzinger MH. 2004. The past, present, and future of web search engines.
31st International Colloquium on Automata, Languages and Programming. ICALP: International
Colloquium on Automata, Languages, and Programming, LNCS, vol. 3142, 3.'
mla: Henzinger, Monika H. “The Past, Present, and Future of Web Search Engines.”
31st International Colloquium on Automata, Languages and Programming, vol.
3142, Springer Nature, 2004, p. 3, doi:10.1007/978-3-540-27836-8_2.
short: M.H. Henzinger, in:, 31st International Colloquium on Automata, Languages
and Programming, Springer Nature, 2004, p. 3.
conference:
end_date: 2004-07-16
location: Turku, Finland
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2004-07-12
date_created: 2022-08-11T12:38:58Z
date_published: 2004-07-01T00:00:00Z
date_updated: 2023-02-13T11:45:25Z
day: '01'
doi: 10.1007/978-3-540-27836-8_2
extern: '1'
intvolume: ' 3142'
language:
- iso: eng
month: '07'
oa_version: None
page: '3'
publication: 31st International Colloquium on Automata, Languages and Programming
publication_identifier:
eissn:
- 1611-3349
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The past, present, and future of web search engines
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3142
year: '2004'
...
---
_id: '11801'
abstract:
- lang: eng
text: "Web search engines have emerged as one of the central applications on the
internet. In fact, search has become one of the most important activities that
people engage in on the Internet. Even beyond becoming the number one source of
information, a growing number of businesses are depending on web search engines
for customer acquisition. In this talk I will brief review the history of web
search engines: The first generation of web search engines used text-only retrieval
techniques. Google revolutionized the field by deploying the PageRank technology
– an eigenvector-based analysis of the hyperlink structure- to analyze the web
in order to produce relevant results. Moving forward, our goal is to achieve a
better understanding of a page with a view towards producing even more relevant
results.\r\n\r\nGoogle is powered by a large number of PCs. Using this infrastructure
and striving to be as efficient as possible poses challenging systems problems
but also various algorithmic challenges. I will discuss some of them in my talk."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Algorithmic aspects of web search engines. In: 2th Annual
European Symposium on Algorithms. Vol 3221. Springer Nature; 2004:3. doi:10.1007/978-3-540-30140-0_2'
apa: 'Henzinger, M. H. (2004). Algorithmic aspects of web search engines. In 2th
Annual European Symposium on Algorithms (Vol. 3221, p. 3). Bergen, Norway:
Springer Nature. https://doi.org/10.1007/978-3-540-30140-0_2'
chicago: Henzinger, Monika H. “Algorithmic Aspects of Web Search Engines.” In 2th
Annual European Symposium on Algorithms, 3221:3. Springer Nature, 2004. https://doi.org/10.1007/978-3-540-30140-0_2.
ieee: M. H. Henzinger, “Algorithmic aspects of web search engines,” in 2th Annual
European Symposium on Algorithms, Bergen, Norway, 2004, vol. 3221, p. 3.
ista: 'Henzinger MH. 2004. Algorithmic aspects of web search engines. 2th Annual
European Symposium on Algorithms. ESA: European Symposium on Algorithms, LNCS,
vol. 3221, 3.'
mla: Henzinger, Monika H. “Algorithmic Aspects of Web Search Engines.” 2th Annual
European Symposium on Algorithms, vol. 3221, Springer Nature, 2004, p. 3,
doi:10.1007/978-3-540-30140-0_2.
short: M.H. Henzinger, in:, 2th Annual European Symposium on Algorithms, Springer
Nature, 2004, p. 3.
conference:
end_date: 2004-09-17
location: Bergen, Norway
name: 'ESA: European Symposium on Algorithms'
start_date: 2004-09-14
date_created: 2022-08-11T13:18:05Z
date_published: 2004-09-01T00:00:00Z
date_updated: 2023-02-13T11:47:26Z
day: '01'
doi: 10.1007/978-3-540-30140-0_2
extern: '1'
intvolume: ' 3221'
language:
- iso: eng
month: '09'
oa_version: None
page: '3'
publication: 2th Annual European Symposium on Algorithms
publication_identifier:
eissn:
- 1611-3349
isbn:
- ' 3540230254'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithmic aspects of web search engines
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3221
year: '2004'
...
---
_id: '11859'
abstract:
- lang: eng
text: In this article we describe the approach taken by the first web search engines,
discuss the state of the art, and present some of the challenges for the future.
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. The past, present, and future of web information retrieval.
In: SPIE Proceedings. Vol 5296. Society of Photo-Optical Instrumentation
Engineers; 2004:23-26. doi:10.1117/12.537534'
apa: 'Henzinger, M. H. (2004). The past, present, and future of web information
retrieval. In SPIE Proceedings (Vol. 5296, pp. 23–26). San Jose, CA, United
States: Society of Photo-Optical Instrumentation Engineers. https://doi.org/10.1117/12.537534'
chicago: Henzinger, Monika H. “The Past, Present, and Future of Web Information
Retrieval.” In SPIE Proceedings, 5296:23–26. Society of Photo-Optical Instrumentation
Engineers, 2004. https://doi.org/10.1117/12.537534.
ieee: M. H. Henzinger, “The past, present, and future of web information retrieval,”
in SPIE Proceedings, San Jose, CA, United States, 2004, vol. 5296, pp.
23–26.
ista: Henzinger MH. 2004. The past, present, and future of web information retrieval.
SPIE Proceedings. Document Recognition and Retrieval XI vol. 5296, 23–26.
mla: Henzinger, Monika H. “The Past, Present, and Future of Web Information Retrieval.”
SPIE Proceedings, vol. 5296, Society of Photo-Optical Instrumentation Engineers,
2004, pp. 23–26, doi:10.1117/12.537534.
short: M.H. Henzinger, in:, SPIE Proceedings, Society of Photo-Optical Instrumentation
Engineers, 2004, pp. 23–26.
conference:
end_date: 2004-01-22
location: San Jose, CA, United States
name: Document Recognition and Retrieval XI
start_date: 2004-01-21
date_created: 2022-08-16T08:46:41Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2023-02-17T10:05:19Z
day: '01'
doi: 10.1117/12.537534
extern: '1'
intvolume: ' 5296'
language:
- iso: eng
month: '01'
oa_version: None
page: 23 - 26
publication: SPIE Proceedings
publication_identifier:
issn:
- 0277-786X
publication_status: published
publisher: Society of Photo-Optical Instrumentation Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: The past, present, and future of web information retrieval
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5296
year: '2004'
...
---
_id: '11877'
abstract:
- lang: eng
text: The World Wide Web provides a unprecedented opportunity to automatically analyze
a large sample of interests and activity in the world. We discuss methods for
extracting knowledge from the web by randomly sampling and analyzing hosts and
pages, and by analyzing the link structure of the web and how links accumulate
over time. A variety of interesting and valuable information can be extracted,
such as the distribution of web pages over domains, the distribution of interest
in different areas, communities related to different topics, the nature of competition
in different categories of sites, and the degree of communication between different
communities or countries.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Steve
full_name: Lawrence, Steve
last_name: Lawrence
citation:
ama: Henzinger MH, Lawrence S. Extracting knowledge from the World Wide Web. Proceedings
of the National Academy of Sciences. 2004;101(suppl_1):5186-5191. doi:10.1073/pnas.0307528100
apa: Henzinger, M. H., & Lawrence, S. (2004). Extracting knowledge from the
World Wide Web. Proceedings of the National Academy of Sciences. Proceedings
of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307528100
chicago: Henzinger, Monika H, and Steve Lawrence. “Extracting Knowledge from the
World Wide Web.” Proceedings of the National Academy of Sciences. Proceedings
of the National Academy of Sciences, 2004. https://doi.org/10.1073/pnas.0307528100.
ieee: M. H. Henzinger and S. Lawrence, “Extracting knowledge from the World Wide
Web,” Proceedings of the National Academy of Sciences, vol. 101, no. suppl_1.
Proceedings of the National Academy of Sciences, pp. 5186–5191, 2004.
ista: Henzinger MH, Lawrence S. 2004. Extracting knowledge from the World Wide Web.
Proceedings of the National Academy of Sciences. 101(suppl_1), 5186–5191.
mla: Henzinger, Monika H., and Steve Lawrence. “Extracting Knowledge from the World
Wide Web.” Proceedings of the National Academy of Sciences, vol. 101, no.
suppl_1, Proceedings of the National Academy of Sciences, 2004, pp. 5186–91, doi:10.1073/pnas.0307528100.
short: M.H. Henzinger, S. Lawrence, Proceedings of the National Academy of Sciences
101 (2004) 5186–5191.
date_created: 2022-08-16T13:06:10Z
date_published: 2004-04-06T00:00:00Z
date_updated: 2023-02-17T12:21:43Z
day: '06'
doi: 10.1073/pnas.0307528100
extern: '1'
external_id:
pmid:
- '14745041'
intvolume: ' 101'
issue: suppl_1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC387294/
month: '04'
oa: 1
oa_version: Published Version
page: 5186-5191
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extracting knowledge from the World Wide Web
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 101
year: '2004'
...
---
_id: '12203'
abstract:
- lang: eng
text: 'Geranylgeranyl diphosphate synthase (GGPPS, EC: 2.5.1.29) catalyzes the biosynthesis
of geranylgeranyl diphosphate (GGPP), which is a key precursor for ginkgolide
biosynthesis. Here we reported for the first time the cloning of a new full-length
cDNA encoding GGPPS from the living fossil plant Ginkgo biloba. The full-length
cDNA encoding G. biloba GGPPS (designated as GbGGPPS) was 1657bp long and contained
a 1176bp open reading frame encoding a 391 amino acid protein. Comparative analysis
showed that GbGGPPS possessed a 79 amino acid transit peptide at its N-terminal,
which directed GbGGPPS to target to the plastids. Bioinformatic analysis revealed
that GbGGPPS was a member of polyprenyltransferases with two highly conserved
aspartate-rich motifs like other plant GGPPSs. Phylogenetic tree analysis indicated
that plant GGPPSs could be classified into two groups, angiosperm and gymnosperm
GGPPSs, while GbGGPPS had closer relationship with gymnosperm plant GGPPSs.'
acknowledgement: This study was financially supported by China National High-Tech
“863” Program. The authors are very thankful to Dr Li Wang (School of Life Sciences,
Fudan University, Shanghai, China) for her kind help with constructing the phylogenetic
tree.
article_processing_charge: No
article_type: original
author:
- first_name: Zhihua
full_name: Liao, Zhihua
last_name: Liao
- first_name: Min
full_name: Chen, Min
last_name: Chen
- first_name: Yifu
full_name: Gong, Yifu
last_name: Gong
- first_name: Liang
full_name: Guo, Liang
last_name: Guo
- first_name: Qiumin
full_name: Tan, Qiumin
last_name: Tan
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Xiaofen
full_name: Sun, Xiaofen
last_name: Sun
- first_name: Feng
full_name: Tan, Feng
last_name: Tan
- first_name: Kexuan
full_name: Tang, Kexuan
last_name: Tang
citation:
ama: Liao Z, Chen M, Gong Y, et al. A new geranylgeranyl Diphosphate synthase gene
from Ginkgo biloba, which intermediates the biosynthesis of the key precursor
for ginkgolides. DNA Sequence. 2004;15(2):153-158. doi:10.1080/10425170410001667348
apa: Liao, Z., Chen, M., Gong, Y., Guo, L., Tan, Q., Feng, X., … Tang, K. (2004).
A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates
the biosynthesis of the key precursor for ginkgolides. DNA Sequence. Informa
UK Limited. https://doi.org/10.1080/10425170410001667348
chicago: Liao, Zhihua, Min Chen, Yifu Gong, Liang Guo, Qiumin Tan, Xiaoqi Feng,
Xiaofen Sun, Feng Tan, and Kexuan Tang. “A New Geranylgeranyl Diphosphate Synthase
Gene from Ginkgo Biloba, Which Intermediates the Biosynthesis of the Key Precursor
for Ginkgolides.” DNA Sequence. Informa UK Limited, 2004. https://doi.org/10.1080/10425170410001667348.
ieee: Z. Liao et al., “A new geranylgeranyl Diphosphate synthase gene from
Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides,”
DNA Sequence, vol. 15, no. 2. Informa UK Limited, pp. 153–158, 2004.
ista: Liao Z, Chen M, Gong Y, Guo L, Tan Q, Feng X, Sun X, Tan F, Tang K. 2004.
A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates
the biosynthesis of the key precursor for ginkgolides. DNA Sequence. 15(2), 153–158.
mla: Liao, Zhihua, et al. “A New Geranylgeranyl Diphosphate Synthase Gene from Ginkgo
Biloba, Which Intermediates the Biosynthesis of the Key Precursor for Ginkgolides.”
DNA Sequence, vol. 15, no. 2, Informa UK Limited, 2004, pp. 153–58, doi:10.1080/10425170410001667348.
short: Z. Liao, M. Chen, Y. Gong, L. Guo, Q. Tan, X. Feng, X. Sun, F. Tan, K. Tang,
DNA Sequence 15 (2004) 153–158.
date_created: 2023-01-16T09:24:50Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2023-05-08T10:58:29Z
department:
- _id: XiFe
doi: 10.1080/10425170410001667348
extern: '1'
external_id:
pmid:
- '15352294'
intvolume: ' 15'
issue: '2'
keyword:
- Endocrinology
- Genetics
- Molecular Biology
- Biochemistry
language:
- iso: eng
oa_version: None
page: 153-158
pmid: 1
publication: DNA Sequence
publication_identifier:
issn:
- 1042-5179
publication_status: published
publisher: Informa UK Limited
quality_controlled: '1'
scopus_import: '1'
status: public
title: A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates
the biosynthesis of the key precursor for ginkgolides
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2004'
...
---
_id: '12658'
abstract:
- lang: eng
text: '[1] During the ablation period 2001 a glaciometeorological experiment was
carried out on Haut Glacier d''Arolla, Switzerland. Five meteorological stations
were installed on the glacier, and one permanent automatic weather station in
the glacier foreland. The altitudes of the stations ranged between 2500 and 3000
m a.s.l., and they were in operation from end of May to beginning of September
2001. The spatial arrangement of the stations and temporal duration of the measurements
generated a unique data set enabling the analysis of the spatial and temporal
variability of the meteorological variables across an alpine glacier. All measurements
were taken at a nominal height of 2 m, and hourly averages were derived for the
analysis. The wind regime was dominated by the glacier wind (mean value 2.8 m
s−1) but due to erosion by the synoptic gradient wind, occasionally the wind would
blow up the valley. A slight decrease in mean 2 m air temperatures with altitude
was found, however the 2 m air temperature gradient varied greatly and frequently
changed its sign. Mean relative humidity was 71% and exhibited limited spatial
variation. Mean incoming shortwave radiation and albedo both generally increased
with elevation. The different components of shortwave radiation are quantified
with a parameterization scheme. Resulting spatial variations are mainly due to
horizon obstruction and reflections from surrounding slopes, i.e., topography.
The effect of clouds accounts for a loss of 30% of the extraterrestrial flux.
Albedos derived from a Landsat TM image of 30 July show remarkably constant values,
in the range 0.49 to 0.50, across snow covered parts of the glacier, while albedo
is highly spatially variable below the zone of continuous snow cover. These results
are verified with ground measurements and compared with parameterized albedo.
Mean longwave radiative fluxes decreased with elevation due to lower air temperatures
and the effect of upper hemisphere slopes. It is shown through parameterization
that this effect would even be more pronounced without the effect of clouds. Results
are discussed with respect to a similar study which has been carried out on Pasterze
Glacier (Austria). The presented algorithms for interpolating, parameterizing
and simulating variables and parameters in alpine regions are integrated in the
software package AMUNDSEN which is freely available to be adapted and further
developed by the community.'
article_number: D03103
article_processing_charge: No
article_type: original
author:
- first_name: Ulrich
full_name: Strasser, Ulrich
last_name: Strasser
- first_name: Javier
full_name: Corripio, Javier
last_name: Corripio
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
- first_name: Ben
full_name: Brock, Ben
last_name: Brock
- first_name: Martin
full_name: Funk, Martin
last_name: Funk
citation:
ama: 'Strasser U, Corripio J, Pellicciotti F, Burlando P, Brock B, Funk M. Spatial
and temporal variability of meteorological variables at Haut Glacier d’Arolla
(Switzerland) during the ablation season 2001: Measurements and simulations. Journal
of Geophysical Research: Atmospheres. 2004;109(D3). doi:10.1029/2003jd003973'
apa: 'Strasser, U., Corripio, J., Pellicciotti, F., Burlando, P., Brock, B., &
Funk, M. (2004). Spatial and temporal variability of meteorological variables
at Haut Glacier d’Arolla (Switzerland) during the ablation season 2001: Measurements
and simulations. Journal of Geophysical Research: Atmospheres. American
Geophysical Union. https://doi.org/10.1029/2003jd003973'
chicago: 'Strasser, Ulrich, Javier Corripio, Francesca Pellicciotti, Paolo Burlando,
Ben Brock, and Martin Funk. “Spatial and Temporal Variability of Meteorological
Variables at Haut Glacier d’Arolla (Switzerland) during the Ablation Season 2001:
Measurements and Simulations.” Journal of Geophysical Research: Atmospheres.
American Geophysical Union, 2004. https://doi.org/10.1029/2003jd003973.'
ieee: 'U. Strasser, J. Corripio, F. Pellicciotti, P. Burlando, B. Brock, and M.
Funk, “Spatial and temporal variability of meteorological variables at Haut Glacier
d’Arolla (Switzerland) during the ablation season 2001: Measurements and simulations,”
Journal of Geophysical Research: Atmospheres, vol. 109, no. D3. American
Geophysical Union, 2004.'
ista: 'Strasser U, Corripio J, Pellicciotti F, Burlando P, Brock B, Funk M. 2004.
Spatial and temporal variability of meteorological variables at Haut Glacier d’Arolla
(Switzerland) during the ablation season 2001: Measurements and simulations. Journal
of Geophysical Research: Atmospheres. 109(D3), D03103.'
mla: 'Strasser, Ulrich, et al. “Spatial and Temporal Variability of Meteorological
Variables at Haut Glacier d’Arolla (Switzerland) during the Ablation Season 2001:
Measurements and Simulations.” Journal of Geophysical Research: Atmospheres,
vol. 109, no. D3, D03103, American Geophysical Union, 2004, doi:10.1029/2003jd003973.'
short: 'U. Strasser, J. Corripio, F. Pellicciotti, P. Burlando, B. Brock, M. Funk,
Journal of Geophysical Research: Atmospheres 109 (2004).'
date_created: 2023-02-20T08:18:57Z
date_published: 2004-02-16T00:00:00Z
date_updated: 2023-02-20T08:40:21Z
day: '16'
doi: 10.1029/2003jd003973
extern: '1'
intvolume: ' 109'
issue: D3
keyword:
- Paleontology
- Space and Planetary Science
- Earth and Planetary Sciences (miscellaneous)
- Atmospheric Science
- Earth-Surface Processes
- Geochemistry and Petrology
- Soil Science
- Water Science and Technology
- Ecology
- Aquatic Science
- Forestry
- Oceanography
- Geophysics
language:
- iso: eng
month: '02'
oa_version: None
publication: 'Journal of Geophysical Research: Atmospheres'
publication_identifier:
issn:
- 0148-0227
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spatial and temporal variability of meteorological variables at Haut Glacier
d''Arolla (Switzerland) during the ablation season 2001: Measurements and simulations'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2004'
...
---
_id: '3419'
abstract:
- lang: eng
text: The folding and stability of transmembrane proteins is a fundamental and unsolved
biological problem. Here, single bacteriorhodopsin molecules were mechanically
unfolded from native purple membranes using atomic force microscopy and force
spectroscopy. The energy landscape of individual transmembrane α helices and polypeptide
loops was mapped by monitoring the pulling speed dependence of the unfolding forces
and applying Monte Carlo simulations. Single helices formed independently stable
units stabilized by a single potential barrier. Mechanical unfolding of the helices
was triggered by 3.9–7.7 Å extension, while natural unfolding rates were of the
order of 10−3 s−1. Besides acting as individually stable units, helices associated
pairwise, establishing a collective potential barrier. The unfolding pathways
of individual proteins reflect distinct pulling speed-dependent unfolding routes
in their energy landscapes. These observations support the two-stage model of
membrane protein folding in which α helices insert into the membrane as stable
units and then assemble into the functional protein.
author:
- first_name: Harald L
full_name: Harald Janovjak
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Jens
full_name: Struckmeier, Jens
last_name: Struckmeier
- first_name: Maurice
full_name: Hubain, Maurice
last_name: Hubain
- first_name: Max
full_name: Kessler, Max
last_name: Kessler
- first_name: Alexej
full_name: Kedrov, Alexej
last_name: Kedrov
- first_name: Daniel
full_name: Mueller, Daniel J
last_name: Mueller
citation:
ama: Janovjak HL, Struckmeier J, Hubain M, Kessler M, Kedrov A, Mueller D. Probing
the energy landscape of the membrane protein bacteriorhodopsin. Structure.
2004;12(5):871-879. doi:10.1016/j.str.2004.03.016
apa: Janovjak, H. L., Struckmeier, J., Hubain, M., Kessler, M., Kedrov, A., &
Mueller, D. (2004). Probing the energy landscape of the membrane protein bacteriorhodopsin.
Structure. Cell Press. https://doi.org/10.1016/j.str.2004.03.016
chicago: Janovjak, Harald L, Jens Struckmeier, Maurice Hubain, Max Kessler, Alexej
Kedrov, and Daniel Mueller. “Probing the Energy Landscape of the Membrane Protein
Bacteriorhodopsin.” Structure. Cell Press, 2004. https://doi.org/10.1016/j.str.2004.03.016.
ieee: H. L. Janovjak, J. Struckmeier, M. Hubain, M. Kessler, A. Kedrov, and D. Mueller,
“Probing the energy landscape of the membrane protein bacteriorhodopsin,” Structure,
vol. 12, no. 5. Cell Press, pp. 871–879, 2004.
ista: Janovjak HL, Struckmeier J, Hubain M, Kessler M, Kedrov A, Mueller D. 2004.
Probing the energy landscape of the membrane protein bacteriorhodopsin. Structure.
12(5), 871–879.
mla: Janovjak, Harald L., et al. “Probing the Energy Landscape of the Membrane Protein
Bacteriorhodopsin.” Structure, vol. 12, no. 5, Cell Press, 2004, pp. 871–79,
doi:10.1016/j.str.2004.03.016.
short: H.L. Janovjak, J. Struckmeier, M. Hubain, M. Kessler, A. Kedrov, D. Mueller,
Structure 12 (2004) 871–879.
date_created: 2018-12-11T12:03:14Z
date_published: 2004-05-01T00:00:00Z
date_updated: 2021-01-12T07:43:20Z
day: '01'
doi: 10.1016/j.str.2004.03.016
extern: 1
intvolume: ' 12'
issue: '5'
month: '05'
page: 871 - 879
publication: Structure
publication_status: published
publisher: Cell Press
publist_id: '2982'
quality_controlled: 0
status: public
title: Probing the energy landscape of the membrane protein bacteriorhodopsin
type: journal_article
volume: 12
year: '2004'
...
---
_id: '3420'
abstract:
- lang: eng
text: Single-molecule force-spectroscopy was employed to unfold and refold single
sodium-proton antiporters (NhaA) of Escherichia coli from membrane patches. Although
transmembrane α-helices and extracellular polypeptide loops exhibited sufficient
stability to individually establish potential barriers against unfolding, two
helices predominantly unfolded pairwise, thereby acting as one structural unit.
Many of the potential barriers were detected unfolding NhaA either from the C-terminal
or the N-terminal end. It was found that some molecular interactions stabilizing
secondary structural elements were directional, while others were not. Additionally,
some interactions appeared to occur between the secondary structural elements.
After unfolding ten of the 12 helices, the extracted polypeptide was allowed to
refold back into the membrane. After five seconds, the refolded polypeptide established
all secondary structure elements of the native protein. One helical pair showed
a characteristic spring like “snap in” into its folded conformation, while the
refolding process of other helices was not detected in particular. Additionally,
individual helices required characteristic periods of time to fold. Correlating
these results with the primary structure of NhaA allowed us to obtain the first
insights into how potential barriers establish and determine the folding kinetics
of the secondary structure elements.
author:
- first_name: Alexej
full_name: Kedrov, Alexej
last_name: Kedrov
- first_name: Christine
full_name: Ziegler, Christine
last_name: Ziegler
- first_name: Harald L
full_name: Harald Janovjak
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
- first_name: Werner
full_name: Kühlbrandt, Werner
last_name: Kühlbrandt
- first_name: Daniel
full_name: Mueller, Daniel J
last_name: Mueller
citation:
ama: Kedrov A, Ziegler C, Janovjak HL, Kühlbrandt W, Mueller D. Controlled unfolding
and refolding of a single sodium/proton antiporter using atomic force microscopy.
Journal of Molecular Biology. 2004;340(5):1143-1152. doi:10.1016/j.jmb.2004.05.026
apa: Kedrov, A., Ziegler, C., Janovjak, H. L., Kühlbrandt, W., & Mueller, D.
(2004). Controlled unfolding and refolding of a single sodium/proton antiporter
using atomic force microscopy. Journal of Molecular Biology. Elsevier.
https://doi.org/10.1016/j.jmb.2004.05.026
chicago: Kedrov, Alexej, Christine Ziegler, Harald L Janovjak, Werner Kühlbrandt,
and Daniel Mueller. “Controlled Unfolding and Refolding of a Single Sodium/Proton
Antiporter Using Atomic Force Microscopy.” Journal of Molecular Biology.
Elsevier, 2004. https://doi.org/10.1016/j.jmb.2004.05.026.
ieee: A. Kedrov, C. Ziegler, H. L. Janovjak, W. Kühlbrandt, and D. Mueller, “Controlled
unfolding and refolding of a single sodium/proton antiporter using atomic force
microscopy,” Journal of Molecular Biology, vol. 340, no. 5. Elsevier, pp.
1143–1152, 2004.
ista: Kedrov A, Ziegler C, Janovjak HL, Kühlbrandt W, Mueller D. 2004. Controlled
unfolding and refolding of a single sodium/proton antiporter using atomic force
microscopy. Journal of Molecular Biology. 340(5), 1143–1152.
mla: Kedrov, Alexej, et al. “Controlled Unfolding and Refolding of a Single Sodium/Proton
Antiporter Using Atomic Force Microscopy.” Journal of Molecular Biology,
vol. 340, no. 5, Elsevier, 2004, pp. 1143–52, doi:10.1016/j.jmb.2004.05.026.
short: A. Kedrov, C. Ziegler, H.L. Janovjak, W. Kühlbrandt, D. Mueller, Journal
of Molecular Biology 340 (2004) 1143–1152.
date_created: 2018-12-11T12:03:14Z
date_published: 2004-07-23T00:00:00Z
date_updated: 2021-01-12T07:43:21Z
day: '23'
doi: 10.1016/j.jmb.2004.05.026
extern: 1
intvolume: ' 340'
issue: '5'
month: '07'
page: 1143 - 1152
publication: Journal of Molecular Biology
publication_status: published
publisher: Elsevier
publist_id: '2981'
quality_controlled: 0
status: public
title: Controlled unfolding and refolding of a single sodium/proton antiporter using
atomic force microscopy
type: journal_article
volume: 340
year: '2004'
...
---
_id: '3574'
author:
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Biological applications of computational topology. In: Handbook
of Discrete and Computational Geometry. CRC Press; 2004:1395-1412.'
apa: Edelsbrunner, H. (2004). Biological applications of computational topology.
In Handbook of Discrete and Computational Geometry (pp. 1395–1412). CRC
Press.
chicago: Edelsbrunner, Herbert. “Biological Applications of Computational Topology.”
In Handbook of Discrete and Computational Geometry, 1395–1412. CRC Press,
2004.
ieee: H. Edelsbrunner, “Biological applications of computational topology,” in Handbook
of Discrete and Computational Geometry, CRC Press, 2004, pp. 1395–1412.
ista: 'Edelsbrunner H. 2004.Biological applications of computational topology. In:
Handbook of Discrete and Computational Geometry. , 1395–1412.'
mla: Edelsbrunner, Herbert. “Biological Applications of Computational Topology.”
Handbook of Discrete and Computational Geometry, CRC Press, 2004, pp. 1395–412.
short: H. Edelsbrunner, in:, Handbook of Discrete and Computational Geometry, CRC
Press, 2004, pp. 1395–1412.
date_created: 2018-12-11T12:04:02Z
date_published: 2004-04-15T00:00:00Z
date_updated: 2021-01-12T07:44:24Z
day: '15'
extern: 1
main_file_link:
- open_access: '0'
url: http://www.cs.duke.edu/~edels/Papers/2004-B-01-BiologicalApplicationsTopology.pdf
month: '04'
page: 1395 - 1412
publication: Handbook of Discrete and Computational Geometry
publication_status: published
publisher: CRC Press
publist_id: '2811'
quality_controlled: 0
status: public
title: Biological applications of computational topology
type: book_chapter
year: '2004'
...
---
_id: '3575'
abstract:
- lang: eng
text: The Jacobi set of two Morse functions defined on a common - manifold is the
set of critical points of the restrictions of one func- tion to the level sets
of the other function. Equivalently, it is the set of points where the gradients
of the functions are parallel. For a generic pair of Morse functions, the Jacobi
set is a smoothly embed- ded 1-manifold. We give a polynomial-time algorithm that
com- putes the piecewise linear analog of the Jacobi set for functions specified
at the vertices of a triangulation, and we generalize all results to more than
two but at most Morse functions.
alternative_title:
- London Mathematical Society Lecture Note
author:
- first_name: Herbert
full_name: Herbert Edelsbrunner
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: John
full_name: Harer, John
last_name: Harer
citation:
ama: 'Edelsbrunner H, Harer J. Jacobi sets of multiple Morse functions. In: Foundations
of Computational Mathematics. Vol 312. Springer; 2004:37-57. doi:10.1017/CBO9781139106962.003'
apa: Edelsbrunner, H., & Harer, J. (2004). Jacobi sets of multiple Morse functions.
In Foundations of Computational Mathematics (Vol. 312, pp. 37–57). Springer.
https://doi.org/10.1017/CBO9781139106962.003
chicago: Edelsbrunner, Herbert, and John Harer. “Jacobi Sets of Multiple Morse Functions.”
In Foundations of Computational Mathematics, 312:37–57. Springer, 2004.
https://doi.org/10.1017/CBO9781139106962.003.
ieee: H. Edelsbrunner and J. Harer, “Jacobi sets of multiple Morse functions,” in
Foundations of Computational Mathematics, vol. 312, Springer, 2004, pp.
37–57.
ista: 'Edelsbrunner H, Harer J. 2004.Jacobi sets of multiple Morse functions. In:
Foundations of Computational Mathematics. London Mathematical Society Lecture
Note, vol. 312, 37–57.'
mla: Edelsbrunner, Herbert, and John Harer. “Jacobi Sets of Multiple Morse Functions.”
Foundations of Computational Mathematics, vol. 312, Springer, 2004, pp.
37–57, doi:10.1017/CBO9781139106962.003.
short: H. Edelsbrunner, J. Harer, in:, Foundations of Computational Mathematics,
Springer, 2004, pp. 37–57.
date_created: 2018-12-11T12:04:02Z
date_published: 2004-01-01T00:00:00Z
date_updated: 2021-01-12T07:44:24Z
day: '01'
doi: 10.1017/CBO9781139106962.003
extern: 1
intvolume: ' 312'
month: '01'
page: 37 - 57
publication: Foundations of Computational Mathematics
publication_status: published
publisher: Springer
publist_id: '2810'
quality_controlled: 0
status: public
title: Jacobi sets of multiple Morse functions
type: book_chapter
volume: 312
year: '2004'
...
---
_id: '3587'
alternative_title:
- Molecular Aspects of Fish and Marine Biology
article_processing_charge: No
author:
- first_name: Florian
full_name: Ulrich, Florian
last_name: Ulrich
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Ulrich F, Heisenberg C-PJ. Gastrulation in zebrafish. In: Korzh V, Gong Z,
eds. Fish Development and Genetics : The Zebrafish and Medaka Models. Vol
2. World Scientific Publishing; 2004:39-86.'
apa: 'Ulrich, F., & Heisenberg, C.-P. J. (2004). Gastrulation in zebrafish.
In V. Korzh & Z. Gong (Eds.), Fish development and genetics : the zebrafish
and medaka models (Vol. 2, pp. 39–86). World Scientific Publishing.'
chicago: 'Ulrich, Florian, and Carl-Philipp J Heisenberg. “Gastrulation in Zebrafish.”
In Fish Development and Genetics : The Zebrafish and Medaka Models, edited
by Vladimir Korzh and Zhiyuan Gong, 2:39–86. World Scientific Publishing, 2004.'
ieee: 'F. Ulrich and C.-P. J. Heisenberg, “Gastrulation in zebrafish,” in Fish
development and genetics : the zebrafish and medaka models, vol. 2, V. Korzh
and Z. Gong, Eds. World Scientific Publishing, 2004, pp. 39–86.'
ista: 'Ulrich F, Heisenberg C-PJ. 2004.Gastrulation in zebrafish. In: Fish development
and genetics : the zebrafish and medaka models. Molecular Aspects of Fish and
Marine Biology, vol. 2, 39–86.'
mla: 'Ulrich, Florian, and Carl-Philipp J. Heisenberg. “Gastrulation in Zebrafish.”
Fish Development and Genetics : The Zebrafish and Medaka Models, edited
by Vladimir Korzh and Zhiyuan Gong, vol. 2, World Scientific Publishing, 2004,
pp. 39–86.'
short: 'F. Ulrich, C.-P.J. Heisenberg, in:, V. Korzh, Z. Gong (Eds.), Fish Development
and Genetics : The Zebrafish and Medaka Models, World Scientific Publishing, 2004,
pp. 39–86.'
date_created: 2018-12-11T12:04:06Z
date_published: 2004-11-01T00:00:00Z
date_updated: 2021-01-12T07:44:29Z
day: '01'
editor:
- first_name: Vladimir
full_name: Korzh, Vladimir
last_name: Korzh
- first_name: Zhiyuan
full_name: Gong, Zhiyuan
last_name: Gong
extern: '1'
intvolume: ' 2'
language:
- iso: eng
month: '11'
oa_version: None
page: 39 - 86
publication: 'Fish development and genetics : the zebrafish and medaka models'
publication_status: published
publisher: World Scientific Publishing
publist_id: '2796'
status: public
title: Gastrulation in zebrafish
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2004'
...
---
_id: '3595'
abstract:
- lang: eng
text: Genome sizes vary enormously. This variation in DNA content correlates with
effective population size, suggesting that deleterious additions to the genome
can accumulate in small populations. On this view, the increased complexity of
biological functions associated with large genomes partly reflects evolutionary
degeneration.
author:
- first_name: Brian
full_name: Charlesworth, Brian
last_name: Charlesworth
- first_name: Nicholas H
full_name: Nicholas Barton
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Charlesworth B, Barton NH. Genome size: Does bigger mean worse? Current
Biology. 2004;14(6):R233-R235. doi:10.1016/j.cub.2004.02.054'
apa: 'Charlesworth, B., & Barton, N. H. (2004). Genome size: Does bigger mean
worse? Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2004.02.054'
chicago: 'Charlesworth, Brian, and Nicholas H Barton. “Genome Size: Does Bigger
Mean Worse?” Current Biology. Cell Press, 2004. https://doi.org/10.1016/j.cub.2004.02.054.'
ieee: 'B. Charlesworth and N. H. Barton, “Genome size: Does bigger mean worse?,”
Current Biology, vol. 14, no. 6. Cell Press, pp. R233–R235, 2004.'
ista: 'Charlesworth B, Barton NH. 2004. Genome size: Does bigger mean worse? Current
Biology. 14(6), R233–R235.'
mla: 'Charlesworth, Brian, and Nicholas H. Barton. “Genome Size: Does Bigger Mean
Worse?” Current Biology, vol. 14, no. 6, Cell Press, 2004, pp. R233–35,
doi:10.1016/j.cub.2004.02.054.'
short: B. Charlesworth, N.H. Barton, Current Biology 14 (2004) R233–R235.
date_created: 2018-12-11T12:04:09Z
date_published: 2004-03-01T00:00:00Z
date_updated: 2019-04-26T07:22:31Z
day: '01'
doi: 10.1016/j.cub.2004.02.054
extern: 1
intvolume: ' 14'
issue: '6'
month: '03'
page: R233 - R235
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '2788'
quality_controlled: 0
status: public
title: 'Genome size: Does bigger mean worse?'
type: review
volume: 14
year: '2004'
...