---
_id: '4550'
abstract:
- lang: eng
text: 'In 2-player non-zero-sum games, Nash equilibria capture the options for rational
behavior if each player attempts to maximize her payoff. In contrast to classical
game theory, we consider lexicographic objectives: first, each player tries to
maximize her own payoff, and then, the player tries to minimize the opponent''s
payoff. Such objectives arise naturally in the verification of systems with multiple
components. There, instead of proving that each component satisfies its specification
no matter how the other components behave, it sometimes suffices to prove that
each component satisfies its specification provided that the other components
satisfy their specifications. We say that a Nash equilibrium is secure if it is
an equilibrium with respect to the lexicographic objectives of both players. We
prove that in graph games with Borel winning conditions, which include the games
that arise in verification, there may be several Nash equilibria, but there is
always a unique maximal payoff profile of a secure equilibrium. We show how this
equilibrium can be computed in the case of ω-regular winning conditions, and we
characterize the memory requirements of strategies that achieve the equilibrium.'
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Thomas Henzinger
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Marcin
full_name: Jurdziński, Marcin
last_name: Jurdziński
citation:
ama: Chatterjee K, Henzinger TA, Jurdziński M. Games with secure equilibria. Theoretical
Computer Science. 2006;365(1-2):67-82. doi:10.1016/j.tcs.2006.07.032
apa: Chatterjee, K., Henzinger, T. A., & Jurdziński, M. (2006). Games with secure
equilibria. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/j.tcs.2006.07.032
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Marcin Jurdziński. “Games
with Secure Equilibria.” Theoretical Computer Science. Elsevier, 2006.
https://doi.org/10.1016/j.tcs.2006.07.032.
ieee: K. Chatterjee, T. A. Henzinger, and M. Jurdziński, “Games with secure equilibria,”
Theoretical Computer Science, vol. 365, no. 1–2. Elsevier, pp. 67–82, 2006.
ista: Chatterjee K, Henzinger TA, Jurdziński M. 2006. Games with secure equilibria.
Theoretical Computer Science. 365(1–2), 67–82.
mla: Chatterjee, Krishnendu, et al. “Games with Secure Equilibria.” Theoretical
Computer Science, vol. 365, no. 1–2, Elsevier, 2006, pp. 67–82, doi:10.1016/j.tcs.2006.07.032.
short: K. Chatterjee, T.A. Henzinger, M. Jurdziński, Theoretical Computer Science
365 (2006) 67–82.
date_created: 2018-12-11T12:09:26Z
date_published: 2006-08-07T00:00:00Z
date_updated: 2021-01-12T07:59:38Z
day: '07'
doi: 10.1016/j.tcs.2006.07.032
extern: 1
intvolume: ' 365'
issue: 1-2
month: '08'
page: 67 - 82
publication: Theoretical Computer Science
publication_status: published
publisher: Elsevier
publist_id: '164'
quality_controlled: 0
status: public
title: Games with secure equilibria
type: journal_article
volume: 365
year: '2006'
...
---
_id: '4551'
abstract:
- lang: eng
text: "We consider Markov decision processes (MDPs) with multiple discounted reward
objectives. Such MDPs occur in design problems where one wishes to simultaneously
optimize several criteria, for example, latency and power. The possible trade-offs
between the different objectives are characterized by the Pareto curve. We show
that every Pareto-optimal point can be achieved by a memoryless strategy; however,
unlike in the single-objective case, the memoryless strategy may require randomization.
Moreover, we show that the Pareto curve can be approximated in polynomial time
in the size of the MDP. Additionally, we study the problem if a given value vector
is realizable by any strategy, and show that it can be decided in polynomial time;
but the question whether it is realizable by a deterministic memoryless strategy
is NP-complete. These results provide efficient algorithms for design exploration
in MDP models with multiple objectives.\nThis research was supported in part by
the AFOSR MURI grant F49620-00-1-0327, and the NSF grants CCR-0225610, CCR-0234690,
and CCR-0427202. "
acknowledgement: This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
and the NSF grants CCR-0225610, CCR-0234690, and CCR-0427202.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Ritankar
full_name: Majumdar, Ritankar S
last_name: Majumdar
- first_name: Thomas A
full_name: Thomas Henzinger
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Chatterjee K, Majumdar R, Henzinger TA. Markov decision processes with multiple
objectives. In: Vol 3884. Springer; 2006:325-336. doi:10.1007/11672142_26'
apa: 'Chatterjee, K., Majumdar, R., & Henzinger, T. A. (2006). Markov decision
processes with multiple objectives (Vol. 3884, pp. 325–336). Presented at the
STACS: Theoretical Aspects of Computer Science, Springer. https://doi.org/10.1007/11672142_26'
chicago: Chatterjee, Krishnendu, Ritankar Majumdar, and Thomas A Henzinger. “Markov
Decision Processes with Multiple Objectives,” 3884:325–36. Springer, 2006. https://doi.org/10.1007/11672142_26.
ieee: 'K. Chatterjee, R. Majumdar, and T. A. Henzinger, “Markov decision processes
with multiple objectives,” presented at the STACS: Theoretical Aspects of Computer
Science, 2006, vol. 3884, pp. 325–336.'
ista: 'Chatterjee K, Majumdar R, Henzinger TA. 2006. Markov decision processes with
multiple objectives. STACS: Theoretical Aspects of Computer Science, LNCS, vol.
3884, 325–336.'
mla: Chatterjee, Krishnendu, et al. Markov Decision Processes with Multiple Objectives.
Vol. 3884, Springer, 2006, pp. 325–36, doi:10.1007/11672142_26.
short: K. Chatterjee, R. Majumdar, T.A. Henzinger, in:, Springer, 2006, pp. 325–336.
conference:
name: 'STACS: Theoretical Aspects of Computer Science'
date_created: 2018-12-11T12:09:26Z
date_published: 2006-02-14T00:00:00Z
date_updated: 2021-01-12T07:59:38Z
day: '14'
doi: 10.1007/11672142_26
extern: 1
intvolume: ' 3884'
month: '02'
page: 325 - 336
publication_status: published
publisher: Springer
publist_id: '161'
quality_controlled: 0
status: public
title: Markov decision processes with multiple objectives
type: conference
volume: 3884
year: '2006'
...
---
_id: '4552'
abstract:
- lang: eng
text: 'A concurrent reachability game is a two-player game played on a graph: at
each state, the players simultaneously and independently select moves; the two
moves determine jointly a probability distribution over the successor states.
The objective for player 1 consists in reaching a set of target states; the objective
for player 2 is to prevent this, so that the game is zero-sum. Our contributions
are two-fold. First, we present a simple proof of the fact that in concurrent
reachability games, for all epsilon > 0, memoryless epsilon-optimal strategies
exist. A memoryless strategy is independent of the history of plays, and an epsilon-optimal
strategy achieves the objective with probability within epsilon of the value of
the game. In contrast to previous proofs of this fact, which rely on the limit
behavior of discounted games using advanced Puisieux series analysis, our proof
is elementary and combinatorial. Second, we present a strategy-improvement (a.k.a.
policy-iteration) algorithm for concurrent games with reachability objectives.'
author:
- first_name: Krishnendu
full_name: Krishnendu Chatterjee
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Luca
full_name: de Alfaro, Luca
last_name: De Alfaro
- first_name: Thomas A
full_name: Thomas Henzinger
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Chatterjee K, De Alfaro L, Henzinger TA. Strategy improvement for concurrent
reachability games. In: IEEE; 2006:291-300. doi:10.1109/QEST.2006.48'
apa: 'Chatterjee, K., De Alfaro, L., & Henzinger, T. A. (2006). Strategy improvement
for concurrent reachability games (pp. 291–300). Presented at the QEST: Quantitative
Evaluation of Systems, IEEE. https://doi.org/10.1109/QEST.2006.48'
chicago: Chatterjee, Krishnendu, Luca De Alfaro, and Thomas A Henzinger. “Strategy
Improvement for Concurrent Reachability Games,” 291–300. IEEE, 2006. https://doi.org/10.1109/QEST.2006.48.
ieee: 'K. Chatterjee, L. De Alfaro, and T. A. Henzinger, “Strategy improvement for
concurrent reachability games,” presented at the QEST: Quantitative Evaluation
of Systems, 2006, pp. 291–300.'
ista: 'Chatterjee K, De Alfaro L, Henzinger TA. 2006. Strategy improvement for concurrent
reachability games. QEST: Quantitative Evaluation of Systems, 291–300.'
mla: Chatterjee, Krishnendu, et al. Strategy Improvement for Concurrent Reachability
Games. IEEE, 2006, pp. 291–300, doi:10.1109/QEST.2006.48.
short: K. Chatterjee, L. De Alfaro, T.A. Henzinger, in:, IEEE, 2006, pp. 291–300.
conference:
name: 'QEST: Quantitative Evaluation of Systems'
date_created: 2018-12-11T12:09:26Z
date_published: 2006-01-01T00:00:00Z
date_updated: 2021-01-12T07:59:39Z
day: '01'
doi: 10.1109/QEST.2006.48
extern: 1
month: '01'
page: 291 - 300
publication_status: published
publisher: IEEE
publist_id: '162'
quality_controlled: 0
status: public
title: Strategy improvement for concurrent reachability games
type: conference
year: '2006'
...
---
_id: '4574'
abstract:
- lang: eng
text: Many software model checkers are based on predicate abstraction. If the verification
goal depends on pointer structures, the approach does not work well, because it
is difficult to find adequate predicate abstractions for the heap. In contrast,
shape analysis, which uses graph-based heap abstractions, can provide a compact
representation of recursive data structures. We integrate shape analysis into
the software model checker Blast. Because shape analysis is expensive, we do not
apply it globally. Instead, we ensure that, like predicates, shape graphs are
computed and stored locally, only where necessary for proving the verification
goal. To achieve this, we extend lazy abstraction refinement, which so far has
been used only for predicate abstractions, to three-valued logical structures.
This approach does not only increase the precision of model checking, but it also
increases the efficiency of shape analysis. We implemented the technique by extending
Blast with calls to Tvla.
alternative_title:
- LNCS
author:
- first_name: Dirk
full_name: Beyer, Dirk
last_name: Beyer
- first_name: Thomas A
full_name: Thomas Henzinger
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Grégory
full_name: Théoduloz, Grégory
last_name: Théoduloz
citation:
ama: 'Beyer D, Henzinger TA, Théoduloz G. Lazy shape analysis. In: Vol 4144. Springer;
2006:532-546. doi:10.1007/11817963_48'
apa: 'Beyer, D., Henzinger, T. A., & Théoduloz, G. (2006). Lazy shape analysis
(Vol. 4144, pp. 532–546). Presented at the CAV: Computer Aided Verification, Springer.
https://doi.org/10.1007/11817963_48'
chicago: Beyer, Dirk, Thomas A Henzinger, and Grégory Théoduloz. “Lazy Shape Analysis,”
4144:532–46. Springer, 2006. https://doi.org/10.1007/11817963_48.
ieee: 'D. Beyer, T. A. Henzinger, and G. Théoduloz, “Lazy shape analysis,” presented
at the CAV: Computer Aided Verification, 2006, vol. 4144, pp. 532–546.'
ista: 'Beyer D, Henzinger TA, Théoduloz G. 2006. Lazy shape analysis. CAV: Computer
Aided Verification, LNCS, vol. 4144, 532–546.'
mla: Beyer, Dirk, et al. Lazy Shape Analysis. Vol. 4144, Springer, 2006,
pp. 532–46, doi:10.1007/11817963_48.
short: D. Beyer, T.A. Henzinger, G. Théoduloz, in:, Springer, 2006, pp. 532–546.
conference:
name: 'CAV: Computer Aided Verification'
date_created: 2018-12-11T12:09:33Z
date_published: 2006-08-08T00:00:00Z
date_updated: 2021-01-12T07:59:49Z
day: '08'
doi: 10.1007/11817963_48
extern: 1
intvolume: ' 4144'
month: '08'
page: 532 - 546
publication_status: published
publisher: Springer
publist_id: '133'
quality_controlled: 0
status: public
title: Lazy shape analysis
type: conference
volume: 4144
year: '2006'
...
---
_id: '12657'
abstract:
- lang: eng
text: An enhanced temperature-index glacier melt model, incorporating incoming shortwave
radiation and albedo, is presented. The model is an attempt to combine the high
temporal resolution and accuracy of physically based melt models with the lower
data requirements and computational simplicity of empirical melt models, represented
by the ‘degree-day’ method and its variants. The model is run with both measured
and modelled radiation data, to test its applicability to glaciers with differing
data availability. Five automatic weather stations were established on Haut Glacier
d’Arolla, Switzerland, between May and September 2001. Reference surface melt
rates were calculated using a physically based energy-balance melt model. The
performance of the enhanced temperature-index model was tested at each of the
four validation stations by comparing predicted hourly melt rates with reference
melt rates. Predictions made with three other temperature-index models were evaluated
in the same way for comparison. The enhanced temperature-index model offers significant
improvements over the other temperature-index models, and accounts for 90–95%
of the variation in the reference melt rate. The improvement is lower, but still
significant, when the model is forced by modelled shortwave radiation data, thus
offering a better alternative to existing models that require only temperature
data input.
article_processing_charge: No
article_type: original
author:
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Ben
full_name: Brock, Ben
last_name: Brock
- first_name: Ulrich
full_name: Strasser, Ulrich
last_name: Strasser
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
- first_name: Martin
full_name: Funk, Martin
last_name: Funk
- first_name: Javier
full_name: Corripio, Javier
last_name: Corripio
citation:
ama: 'Pellicciotti F, Brock B, Strasser U, Burlando P, Funk M, Corripio J. An enhanced
temperature-index glacier melt model including the shortwave radiation balance:
Development and testing for Haut Glacier d’Arolla, Switzerland. Journal of
Glaciology. 2005;51(175):573-587. doi:10.3189/172756505781829124'
apa: 'Pellicciotti, F., Brock, B., Strasser, U., Burlando, P., Funk, M., & Corripio,
J. (2005). An enhanced temperature-index glacier melt model including the shortwave
radiation balance: Development and testing for Haut Glacier d’Arolla, Switzerland.
Journal of Glaciology. Cambridge University Press. https://doi.org/10.3189/172756505781829124'
chicago: 'Pellicciotti, Francesca, Ben Brock, Ulrich Strasser, Paolo Burlando, Martin
Funk, and Javier Corripio. “An Enhanced Temperature-Index Glacier Melt Model Including
the Shortwave Radiation Balance: Development and Testing for Haut Glacier d’Arolla,
Switzerland.” Journal of Glaciology. Cambridge University Press, 2005.
https://doi.org/10.3189/172756505781829124.'
ieee: 'F. Pellicciotti, B. Brock, U. Strasser, P. Burlando, M. Funk, and J. Corripio,
“An enhanced temperature-index glacier melt model including the shortwave radiation
balance: Development and testing for Haut Glacier d’Arolla, Switzerland,” Journal
of Glaciology, vol. 51, no. 175. Cambridge University Press, pp. 573–587,
2005.'
ista: 'Pellicciotti F, Brock B, Strasser U, Burlando P, Funk M, Corripio J. 2005.
An enhanced temperature-index glacier melt model including the shortwave radiation
balance: Development and testing for Haut Glacier d’Arolla, Switzerland. Journal
of Glaciology. 51(175), 573–587.'
mla: 'Pellicciotti, Francesca, et al. “An Enhanced Temperature-Index Glacier Melt
Model Including the Shortwave Radiation Balance: Development and Testing for Haut
Glacier d’Arolla, Switzerland.” Journal of Glaciology, vol. 51, no. 175,
Cambridge University Press, 2005, pp. 573–87, doi:10.3189/172756505781829124.'
short: F. Pellicciotti, B. Brock, U. Strasser, P. Burlando, M. Funk, J. Corripio,
Journal of Glaciology 51 (2005) 573–587.
date_created: 2023-02-20T08:18:51Z
date_published: 2005-10-19T00:00:00Z
date_updated: 2023-02-20T08:45:37Z
day: '19'
doi: 10.3189/172756505781829124
extern: '1'
intvolume: ' 51'
issue: '175'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3189/172756505781829124
month: '10'
oa: 1
oa_version: Published Version
page: 573-587
publication: Journal of Glaciology
publication_identifier:
eissn:
- 1727-5652
issn:
- 0022-1430
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'An enhanced temperature-index glacier melt model including the shortwave radiation
balance: Development and testing for Haut Glacier d’Arolla, Switzerland'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2005'
...
---
_id: '1298'
abstract:
- lang: eng
text: Genetically encoded fluorescent probes of neural activity represent new promising
tools for systems neuroscience. Here, we present a comparative in vivo analysis
of 10 different genetically encoded calcium indicators, as well as the pH-sensitive
synapto-pHluorin. We analyzed their fluorescence changes in presynaptic boutons
of the Drosophila larval neuromuscular junction. Robust neural activity did not
result in any or noteworthy fluorescence changes when Flash-Pericam, Camgaroo-1,
and Camgaroo-2 were expressed. However, calculated on the raw data, fractional
fluorescence changes up to 18% were reported by synapto-pHluorin, Yellow Cameleon
2.0, 2.3, and 3.3, Inverse-Pericam, GCaMP1.3, GCaMP1.6, and the troponin C-based
calcium sensor TN-L15. The response characteristics of all of these indicators
differed considerably from each other, with GCaMP1.6 reporting high rates of neural
activity with the largest and fastest fluorescence changes. However, GCaMP1.6
suffered from photobleaching, whereas the fluorescence signals of the double-chromophore
indicators were in general smaller but more photostable and reproducible, with
TN-L15 showing the fastest rise of the signals at lower activity rates. We show
for GCaMP1.3 and YC3.3 that an expanded range of neural activity evoked fairly
linear fluorescence changes and a corresponding linear increase in the signal-to-noise
ratio (SNR). The expression level of the indicator biased the signal kinetics
and SNR, whereas the signal amplitude was independent. The presented data will
be useful for in vivo experiments with respect to the selection of an appropriate
indicator, as well as for the correct interpretation of the optical signals.
acknowledgement: This work was supported by the Max-Planck-Society.
author:
- first_name: Dierk
full_name: Reiff, Dierk F
last_name: Reiff
- first_name: Alexandra
full_name: Ihring, Alexandra
last_name: Ihring
- first_name: Giovanna
full_name: Guerrero, Giovanna
last_name: Guerrero
- first_name: Ehud
full_name: Isacoff, Ehud Y
last_name: Isacoff
- first_name: Maximilian A
full_name: Maximilian Jösch
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Junichi
full_name: Nakai, Junichi
last_name: Nakai
- first_name: Alexander
full_name: Borst, Alexander
last_name: Borst
citation:
ama: Reiff D, Ihring A, Guerrero G, et al. In vivo performance of genetically encoded
indicators of neural activity in flies. Journal of Neuroscience. 2005;25(19):4766-4778.
doi:10.1523/JNEUROSCI.4900-04.2005
apa: Reiff, D., Ihring, A., Guerrero, G., Isacoff, E., Jösch, M. A., Nakai, J.,
& Borst, A. (2005). In vivo performance of genetically encoded indicators
of neural activity in flies. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.4900-04.2005
chicago: Reiff, Dierk, Alexandra Ihring, Giovanna Guerrero, Ehud Isacoff, Maximilian
A Jösch, Junichi Nakai, and Alexander Borst. “In Vivo Performance of Genetically
Encoded Indicators of Neural Activity in Flies.” Journal of Neuroscience.
Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.4900-04.2005.
ieee: D. Reiff et al., “In vivo performance of genetically encoded indicators
of neural activity in flies,” Journal of Neuroscience, vol. 25, no. 19.
Society for Neuroscience, pp. 4766–4778, 2005.
ista: Reiff D, Ihring A, Guerrero G, Isacoff E, Jösch MA, Nakai J, Borst A. 2005.
In vivo performance of genetically encoded indicators of neural activity in flies.
Journal of Neuroscience. 25(19), 4766–4778.
mla: Reiff, Dierk, et al. “In Vivo Performance of Genetically Encoded Indicators
of Neural Activity in Flies.” Journal of Neuroscience, vol. 25, no. 19,
Society for Neuroscience, 2005, pp. 4766–78, doi:10.1523/JNEUROSCI.4900-04.2005.
short: D. Reiff, A. Ihring, G. Guerrero, E. Isacoff, M.A. Jösch, J. Nakai, A. Borst,
Journal of Neuroscience 25 (2005) 4766–4778.
date_created: 2018-12-11T11:51:13Z
date_published: 2005-03-11T00:00:00Z
date_updated: 2021-01-12T06:49:42Z
day: '11'
doi: 10.1523/JNEUROSCI.4900-04.2005
extern: 1
intvolume: ' 25'
issue: '19'
month: '03'
page: 4766 - 4778
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '5975'
quality_controlled: 0
status: public
title: In vivo performance of genetically encoded indicators of neural activity in
flies
type: journal_article
volume: 25
year: '2005'
...
---
_id: '843'
abstract:
- lang: eng
text: The impact of an amino acid replacement on the organism's fitness can vary
from lethal to selectively neutral and even, in rare cases, beneficial. Substantial
data are available on either pathogenic or acceptable replacements. However, the
whole distribution of coefficients of selection against individual replacements
is not known for any organism. To ascertain this distribution for human proteins,
we combined data on pathogenic missense mutations, on human non-synonymous SNPs
and on human-chimpanzee divergence of orthologous proteins. Fractions of amino
acid replacements which reduce fitness by >10-2, 10-2-10-4, 10-4-10-5 and <10-5
are 25, 49, 14 and 12%, respectively. On average, the strength of selection against
a replacement is substantially higher when chemically dissimilar amino acids are
involved, and the Grantham's index of a replacement explains 35% of variance in
the average logarithm of selection coefficients associated with different replacements.
Still, the impact of a replacement depends on its context within the protein more
than on its own nature. Reciprocal replacements are often associated with rather
different selection coefficients, in particular, replacements of non-polar amino
acids with polar ones are typically much more deleterious than replacements in
the opposite direction. However, differences between evolutionary fluxes of reciprocal
replacements are only weakly correlated with the differences between the corresponding
selection coefficients.
author:
- first_name: Lev
full_name: Yampolsky, Lev Y
last_name: Yampolsky
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Alexey
full_name: Kondrashov, Alexey S
last_name: Kondrashov
citation:
ama: Yampolsky L, Kondrashov F, Kondrashov A. Distribution of the strength of selection
against amino acid replacements in human proteins. Human Molecular Genetics.
2005;14(21):3191-3201. doi:10.1093/hmg/ddi350
apa: Yampolsky, L., Kondrashov, F., & Kondrashov, A. (2005). Distribution of
the strength of selection against amino acid replacements in human proteins. Human
Molecular Genetics. Oxford University Press. https://doi.org/10.1093/hmg/ddi350
chicago: Yampolsky, Lev, Fyodor Kondrashov, and Alexey Kondrashov. “Distribution
of the Strength of Selection against Amino Acid Replacements in Human Proteins.”
Human Molecular Genetics. Oxford University Press, 2005. https://doi.org/10.1093/hmg/ddi350.
ieee: L. Yampolsky, F. Kondrashov, and A. Kondrashov, “Distribution of the strength
of selection against amino acid replacements in human proteins,” Human Molecular
Genetics, vol. 14, no. 21. Oxford University Press, pp. 3191–3201, 2005.
ista: Yampolsky L, Kondrashov F, Kondrashov A. 2005. Distribution of the strength
of selection against amino acid replacements in human proteins. Human Molecular
Genetics. 14(21), 3191–3201.
mla: Yampolsky, Lev, et al. “Distribution of the Strength of Selection against Amino
Acid Replacements in Human Proteins.” Human Molecular Genetics, vol. 14,
no. 21, Oxford University Press, 2005, pp. 3191–201, doi:10.1093/hmg/ddi350.
short: L. Yampolsky, F. Kondrashov, A. Kondrashov, Human Molecular Genetics 14 (2005)
3191–3201.
date_created: 2018-12-11T11:48:48Z
date_published: 2005-11-01T00:00:00Z
date_updated: 2021-01-12T08:19:13Z
day: '01'
doi: 10.1093/hmg/ddi350
extern: 1
intvolume: ' 14'
issue: '21'
month: '11'
page: 3191 - 3201
publication: Human Molecular Genetics
publication_status: published
publisher: Oxford University Press
publist_id: '6807'
quality_controlled: 0
status: public
title: Distribution of the strength of selection against amino acid replacements in
human proteins
type: journal_article
volume: 14
year: '2005'
...
---
_id: '8491'
abstract:
- lang: eng
text: Fast multidimensional NMR with a time resolution of a few seconds provides
a new tool for high throughput screening and site-resolved real-time studies of
kinetic molecular processes by NMR. Recently we have demonstrated the feasibility
to record protein 1H–15N correlation spectra in a few seconds of acquisition time
using a new SOFAST-HMQC experiment (Schanda and Brutscher (2005) J. Am. Chem.
Soc. 127, 8014). Here, we investigate in detail the performance of SOFAST-HMQC
to record 1H–15N and 1H−13C correlation spectra of proteins of different size
and at different magnetic field strengths. Compared to standard 1H–15N correlation
experiments SOFAST-HMQC provides a significant gain in sensitivity, especially
for fast repetition rates. Guidelines are provided on how to set up SOFAST-HMQC
experiments for a given protein sample. In addition, an alternative pulse scheme,
IPAP-SOFAST-HMQC is presented that allows application on NMR spectrometers equipped
with cryogenic probes, and fast measurement of one-bond 1H–13C and 1H–15N scalar
and residual dipolar coupling constants.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Ēriks
full_name: Kupče, Ēriks
last_name: Kupče
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Schanda P, Kupče Ē, Brutscher B. SOFAST-HMQC experiments for recording two-dimensional
deteronuclear correlation spectra of proteins within a few seconds. Journal
of Biomolecular NMR. 2005;33(4):199-211. doi:10.1007/s10858-005-4425-x
apa: Schanda, P., Kupče, Ē., & Brutscher, B. (2005). SOFAST-HMQC experiments
for recording two-dimensional deteronuclear correlation spectra of proteins within
a few seconds. Journal of Biomolecular NMR. Springer Nature. https://doi.org/10.1007/s10858-005-4425-x
chicago: Schanda, Paul, Ēriks Kupče, and Bernhard Brutscher. “SOFAST-HMQC Experiments
for Recording Two-Dimensional Deteronuclear Correlation Spectra of Proteins within
a Few Seconds.” Journal of Biomolecular NMR. Springer Nature, 2005. https://doi.org/10.1007/s10858-005-4425-x.
ieee: P. Schanda, Ē. Kupče, and B. Brutscher, “SOFAST-HMQC experiments for recording
two-dimensional deteronuclear correlation spectra of proteins within a few seconds,”
Journal of Biomolecular NMR, vol. 33, no. 4. Springer Nature, pp. 199–211,
2005.
ista: Schanda P, Kupče Ē, Brutscher B. 2005. SOFAST-HMQC experiments for recording
two-dimensional deteronuclear correlation spectra of proteins within a few seconds.
Journal of Biomolecular NMR. 33(4), 199–211.
mla: Schanda, Paul, et al. “SOFAST-HMQC Experiments for Recording Two-Dimensional
Deteronuclear Correlation Spectra of Proteins within a Few Seconds.” Journal
of Biomolecular NMR, vol. 33, no. 4, Springer Nature, 2005, pp. 199–211, doi:10.1007/s10858-005-4425-x.
short: P. Schanda, Ē. Kupče, B. Brutscher, Journal of Biomolecular NMR 33 (2005)
199–211.
date_created: 2020-09-18T10:13:59Z
date_published: 2005-12-01T00:00:00Z
date_updated: 2021-01-12T08:19:38Z
day: '01'
doi: 10.1007/s10858-005-4425-x
extern: '1'
intvolume: ' 33'
issue: '4'
keyword:
- Spectroscopy
- Biochemistry
language:
- iso: eng
month: '12'
oa_version: None
page: 199-211
publication: Journal of Biomolecular NMR
publication_identifier:
issn:
- 0925-2738
- 1573-5001
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: SOFAST-HMQC experiments for recording two-dimensional deteronuclear correlation
spectra of proteins within a few seconds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2005'
...
---
_id: '8492'
abstract:
- lang: eng
text: We demonstrate for different protein samples that 2D 1H−15N correlation NMR
spectra can be recorded in a few seconds of acquisition time using a new band-selective
optimized flip-angle short-transient heteronuclear multiple quantum coherence
experiment. This has enabled us to measure fast hydrogen−deuterium exchange rate
constants along the backbone of a small globular protein fragment by real-time
2D NMR.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Schanda P, Brutscher B. Very fast two-dimensional NMR spectroscopy for real-time
investigation of dynamic events in proteins on the time scale of seconds. Journal
of the American Chemical Society. 2005;127(22):8014-8015. doi:10.1021/ja051306e
apa: Schanda, P., & Brutscher, B. (2005). Very fast two-dimensional NMR spectroscopy
for real-time investigation of dynamic events in proteins on the time scale of
seconds. Journal of the American Chemical Society. American Chemical Society.
https://doi.org/10.1021/ja051306e
chicago: Schanda, Paul, and Bernhard Brutscher. “Very Fast Two-Dimensional NMR Spectroscopy
for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of
Seconds.” Journal of the American Chemical Society. American Chemical Society,
2005. https://doi.org/10.1021/ja051306e.
ieee: P. Schanda and B. Brutscher, “Very fast two-dimensional NMR spectroscopy for
real-time investigation of dynamic events in proteins on the time scale of seconds,”
Journal of the American Chemical Society, vol. 127, no. 22. American Chemical
Society, pp. 8014–8015, 2005.
ista: Schanda P, Brutscher B. 2005. Very fast two-dimensional NMR spectroscopy for
real-time investigation of dynamic events in proteins on the time scale of seconds.
Journal of the American Chemical Society. 127(22), 8014–8015.
mla: Schanda, Paul, and Bernhard Brutscher. “Very Fast Two-Dimensional NMR Spectroscopy
for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of
Seconds.” Journal of the American Chemical Society, vol. 127, no. 22, American
Chemical Society, 2005, pp. 8014–15, doi:10.1021/ja051306e.
short: P. Schanda, B. Brutscher, Journal of the American Chemical Society 127 (2005)
8014–8015.
date_created: 2020-09-18T10:14:05Z
date_published: 2005-05-14T00:00:00Z
date_updated: 2021-01-12T08:19:39Z
day: '14'
doi: 10.1021/ja051306e
extern: '1'
intvolume: ' 127'
issue: '22'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '05'
oa_version: None
page: 8014-8015
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Very fast two-dimensional NMR spectroscopy for real-time investigation of dynamic
events in proteins on the time scale of seconds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 127
year: '2005'
...
---
_id: '8516'
abstract:
- lang: eng
text: "The purpose of this paper is to construct examples of diffusion for E-Hamiltonian
perturbations\r\nof completely integrable Hamiltonian systems in 2d-dimensional
phase space, with d large.\r\nIn the first part of the paper, simple and explicit
examples are constructed illustrating absence\r\nof ‘long-time’ stability for
size E Hamiltonian perturbations of quasi-convex integrable systems\r\nalready
when the dimension 2d of phase space becomes as large as log 1/E . We first produce\r\nthe
example in Gevrey class and then a real analytic one, with some additional work.\r\nIn
the second part, we consider again E-Hamiltonian perturbations of completely integrable\r\nHamiltonian
system in 2d-dimensional space with E-small but not too small, |E| > exp(−d),
with\r\nd the number of degrees of freedom assumed large. It is shown that for
a class of analytic\r\ntime-periodic perturbations, there exist linearly diffusing
trajectories. The underlying idea for\r\nboth examples is similar and consists
in coupling a fixed degree of freedom with a large\r\nnumber of them. The procedure
and analytical details are however significantly different. As\r\nmentioned, the
construction in Part I is totally elementary while Part II is more involved, relying\r\nin
particular on the theory of normally hyperbolic invariant manifolds, methods of
generating\r\nfunctions, Aubry–Mather theory, and Mather’s variational methods."
article_processing_charge: No
article_type: original
author:
- first_name: Jean
full_name: Bourgain, Jean
last_name: Bourgain
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Bourgain J, Kaloshin V. On diffusion in high-dimensional Hamiltonian systems.
Journal of Functional Analysis. 2005;229(1):1-61. doi:10.1016/j.jfa.2004.09.006
apa: Bourgain, J., & Kaloshin, V. (2005). On diffusion in high-dimensional Hamiltonian
systems. Journal of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2004.09.006
chicago: Bourgain, Jean, and Vadim Kaloshin. “On Diffusion in High-Dimensional Hamiltonian
Systems.” Journal of Functional Analysis. Elsevier, 2005. https://doi.org/10.1016/j.jfa.2004.09.006.
ieee: J. Bourgain and V. Kaloshin, “On diffusion in high-dimensional Hamiltonian
systems,” Journal of Functional Analysis, vol. 229, no. 1. Elsevier, pp.
1–61, 2005.
ista: Bourgain J, Kaloshin V. 2005. On diffusion in high-dimensional Hamiltonian
systems. Journal of Functional Analysis. 229(1), 1–61.
mla: Bourgain, Jean, and Vadim Kaloshin. “On Diffusion in High-Dimensional Hamiltonian
Systems.” Journal of Functional Analysis, vol. 229, no. 1, Elsevier, 2005,
pp. 1–61, doi:10.1016/j.jfa.2004.09.006.
short: J. Bourgain, V. Kaloshin, Journal of Functional Analysis 229 (2005) 1–61.
date_created: 2020-09-18T10:49:06Z
date_published: 2005-12-01T00:00:00Z
date_updated: 2021-01-12T08:19:49Z
day: '01'
doi: 10.1016/j.jfa.2004.09.006
extern: '1'
intvolume: ' 229'
issue: '1'
keyword:
- Analysis
language:
- iso: eng
month: '12'
oa_version: None
page: 1-61
publication: Journal of Functional Analysis
publication_identifier:
issn:
- 0022-1236
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: On diffusion in high-dimensional Hamiltonian systems
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 229
year: '2005'
...
---
_id: '877'
abstract:
- lang: eng
text: "Sequence analysis of protein and mitochondrially encoded tRNA genes shows
that substitutions\r\nproducing pathogenic effects in humans are often found in
normal, healthy individuals from other species.\r\nAnalysis of stability of protein
and tRNA structures shows that the disease-causing effects of pathogenic\r\nmutations
can be neutralized by other, compensatory substitutions that restore the structural
stability of the\r\nmolecule. Further study of such substitutions will, hopefully,
lead to new methods for curing genetic dis-\r\neases that may be based on the
correction of molecule stability as a whole instead of reversing an individual\r\npathogenic
mutation."
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov F. The analysis of monomer sequences in protein and tRNA and the
manifestation of the compensation of pathogenic deviations in their evolution.
Biofizika. 2005;50(3):389-395.
apa: Kondrashov, F. (2005). The analysis of monomer sequences in protein and tRNA
and the manifestation of the compensation of pathogenic deviations in their evolution.
Biofizika. Pleiades Publishing.
chicago: Kondrashov, Fyodor. “The Analysis of Monomer Sequences in Protein and TRNA
and the Manifestation of the Compensation of Pathogenic Deviations in Their Evolution.”
Biofizika. Pleiades Publishing, 2005.
ieee: F. Kondrashov, “The analysis of monomer sequences in protein and tRNA and
the manifestation of the compensation of pathogenic deviations in their evolution,”
Biofizika, vol. 50, no. 3. Pleiades Publishing, pp. 389–395, 2005.
ista: Kondrashov F. 2005. The analysis of monomer sequences in protein and tRNA
and the manifestation of the compensation of pathogenic deviations in their evolution.
Biofizika. 50(3), 389–395.
mla: Kondrashov, Fyodor. “The Analysis of Monomer Sequences in Protein and TRNA
and the Manifestation of the Compensation of Pathogenic Deviations in Their Evolution.”
Biofizika, vol. 50, no. 3, Pleiades Publishing, 2005, pp. 389–95.
short: F. Kondrashov, Biofizika 50 (2005) 389–395.
date_created: 2018-12-11T11:48:58Z
date_published: 2005-05-01T00:00:00Z
date_updated: 2021-01-12T08:21:01Z
day: '01'
extern: '1'
external_id:
pmid:
- '15977826'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
main_file_link:
- url: http://pleiades.online/abstract/biophys/5/biophys0349_abstract.pdf
month: '05'
oa_version: None
page: 389 - 395
pmid: 1
publication: Biofizika
publication_status: published
publisher: Pleiades Publishing
publist_id: '6769'
quality_controlled: '1'
status: public
title: The analysis of monomer sequences in protein and tRNA and the manifestation
of the compensation of pathogenic deviations in their evolution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2005'
...
---
_id: '878'
abstract:
- lang: eng
text: |
Negative trade-offs are thought to be a pervasive phenomenon and to inhibit evolution at all levels. New evidence shows that at the molecular level, there may be no trade-offs preventing the emergence of an enzyme with multiple functions.
author:
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov F. In search of the limits of evolution. Nature Genetics.
2005;37(1):9-10. doi:10.1038/ng0105-9
apa: Kondrashov, F. (2005). In search of the limits of evolution. Nature Genetics.
Nature Publishing Group. https://doi.org/10.1038/ng0105-9
chicago: Kondrashov, Fyodor. “In Search of the Limits of Evolution.” Nature Genetics.
Nature Publishing Group, 2005. https://doi.org/10.1038/ng0105-9.
ieee: F. Kondrashov, “In search of the limits of evolution,” Nature Genetics,
vol. 37, no. 1. Nature Publishing Group, pp. 9–10, 2005.
ista: Kondrashov F. 2005. In search of the limits of evolution. Nature Genetics.
37(1), 9–10.
mla: Kondrashov, Fyodor. “In Search of the Limits of Evolution.” Nature Genetics,
vol. 37, no. 1, Nature Publishing Group, 2005, pp. 9–10, doi:10.1038/ng0105-9.
short: F. Kondrashov, Nature Genetics 37 (2005) 9–10.
date_created: 2018-12-11T11:48:59Z
date_published: 2005-01-01T00:00:00Z
date_updated: 2021-01-12T08:21:02Z
day: '01'
doi: 10.1038/ng0105-9
extern: 1
intvolume: ' 37'
issue: '1'
month: '01'
page: 9 - 10
publication: Nature Genetics
publication_status: published
publisher: Nature Publishing Group
publist_id: '6770'
quality_controlled: 0
status: public
title: In search of the limits of evolution
type: journal_article
volume: 37
year: '2005'
...
---
_id: '880'
abstract:
- lang: eng
text: Here, I describe a case of loss of the D-arm by mitochondrial cysteine tRNA
in the nine-banded armadillo (Dasypus novemcinctus) convergent with mt tRNASer(AGY).
Such evolution sheds light on the relationship between structure and function
of tRNA molecules and its impact on the patterns of molecular evolution.
article_processing_charge: No
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov F. The convergent evolution of the secondary structure of mitochondrial
cysteine tRNA in the nine-banded armadillo Dasypus novemcinctus. Biofizika.
2005;50(3):396-403.
apa: Kondrashov, F. (2005). The convergent evolution of the secondary structure
of mitochondrial cysteine tRNA in the nine-banded armadillo Dasypus novemcinctus.
Biofizika. Pleiades Publishing.
chicago: Kondrashov, Fyodor. “The Convergent Evolution of the Secondary Structure
of Mitochondrial Cysteine TRNA in the Nine-Banded Armadillo Dasypus Novemcinctus.”
Biofizika. Pleiades Publishing, 2005.
ieee: F. Kondrashov, “The convergent evolution of the secondary structure of mitochondrial
cysteine tRNA in the nine-banded armadillo Dasypus novemcinctus,” Biofizika,
vol. 50, no. 3. Pleiades Publishing, pp. 396–403, 2005.
ista: Kondrashov F. 2005. The convergent evolution of the secondary structure of
mitochondrial cysteine tRNA in the nine-banded armadillo Dasypus novemcinctus.
Biofizika. 50(3), 396–403.
mla: Kondrashov, Fyodor. “The Convergent Evolution of the Secondary Structure of
Mitochondrial Cysteine TRNA in the Nine-Banded Armadillo Dasypus Novemcinctus.”
Biofizika, vol. 50, no. 3, Pleiades Publishing, 2005, pp. 396–403.
short: F. Kondrashov, Biofizika 50 (2005) 396–403.
date_created: 2018-12-11T11:48:59Z
date_published: 2005-05-01T00:00:00Z
date_updated: 2021-01-12T08:21:07Z
day: '01'
extern: '1'
external_id:
pmid:
- '15977827'
intvolume: ' 50'
issue: '3'
language:
- iso: eng
main_file_link:
- url: http://pleiades.online/abstract/biophys/5/biophys0356_abstract.pdf
month: '05'
oa_version: None
page: 396 - 403
pmid: 1
publication: Biofizika
publication_status: published
publisher: Pleiades Publishing
publist_id: '6768'
quality_controlled: '1'
status: public
title: The convergent evolution of the secondary structure of mitochondrial cysteine
tRNA in the nine-banded armadillo Dasypus novemcinctus
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2005'
...
---
_id: '882'
abstract:
- lang: eng
text: Some mutations in human mitochondrial tRNAs are severely pathogenic. The available
computational methods have a poor record of predicting the impact of a tRNA mutation
on the phenotype and fitness. Here patterns of evolution at tRNA sites that harbor
pathogenic mutations and at sites that harbor phenotypically cryptic polymorphisms
were compared. Mutations that are pathogenic to humans occupy more conservative
sites, are only rarely fixed in closely related species, and, when located in
stem structures, often disrupt Watson-Crick pairing and display signs of compensatory
evolution. These observations make it possible to classify ∼90% of all known pathogenic
mutations as deleterious together with only ∼30% of polymorphisms. These polymorphisms
segregate at frequencies that are more than two times lower than frequencies of
polymorphisms classified as benign, indicating that at least ∼30% of known polymorphisms
in mitochondrial tRNAs affect fitness negatively.
acknowledgement: |
The author thanks P. Andolfatto, D. Bachtrog, N. Esipova, S. Makeev, A. Kondrashov, V. Ramensky, V. Tumanyan and P. Vlasov for a critical reading of the manuscript. The author is an NSF Graduate Research Fellow. This work was supported by a Contract of the Russian Ministry of Science and Education (02.434.11.1008) and a grant on Molecular and Cellular Biology from RAS.
author:
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov F. Prediction of pathogenic mutations in mitochondrially encoded
human tRNAs. Human Molecular Genetics. 2005;14(16):2415-2419. doi:10.1093/hmg/ddi243
apa: Kondrashov, F. (2005). Prediction of pathogenic mutations in mitochondrially
encoded human tRNAs. Human Molecular Genetics. Oxford University Press.
https://doi.org/10.1093/hmg/ddi243
chicago: Kondrashov, Fyodor. “Prediction of Pathogenic Mutations in Mitochondrially
Encoded Human TRNAs.” Human Molecular Genetics. Oxford University Press,
2005. https://doi.org/10.1093/hmg/ddi243.
ieee: F. Kondrashov, “Prediction of pathogenic mutations in mitochondrially encoded
human tRNAs,” Human Molecular Genetics, vol. 14, no. 16. Oxford University
Press, pp. 2415–2419, 2005.
ista: Kondrashov F. 2005. Prediction of pathogenic mutations in mitochondrially
encoded human tRNAs. Human Molecular Genetics. 14(16), 2415–2419.
mla: Kondrashov, Fyodor. “Prediction of Pathogenic Mutations in Mitochondrially
Encoded Human TRNAs.” Human Molecular Genetics, vol. 14, no. 16, Oxford
University Press, 2005, pp. 2415–19, doi:10.1093/hmg/ddi243.
short: F. Kondrashov, Human Molecular Genetics 14 (2005) 2415–2419.
date_created: 2018-12-11T11:49:00Z
date_published: 2005-08-15T00:00:00Z
date_updated: 2021-01-12T08:21:10Z
day: '15'
doi: 10.1093/hmg/ddi243
extern: 1
intvolume: ' 14'
issue: '16'
month: '08'
page: 2415 - 2419
publication: Human Molecular Genetics
publication_status: published
publisher: Oxford University Press
publist_id: '6767'
quality_controlled: 0
status: public
title: Prediction of pathogenic mutations in mitochondrially encoded human tRNAs
type: journal_article
volume: 14
year: '2005'
...
---
_id: '893'
abstract:
- lang: eng
text: Amino acid composition of proteins varies substantially between taxa and,
thus, can evolve. For example, proteins from organisms with (G+C)-rich (or (A+T)-rich)
genomes contain more (or fewer) amino acids encoded by (G+C)-rich codons. However,
no universal trends in ongoing changes of amino acid frequencies have been reported.
We compared sets of orthologous proteins encoded by triplets of closely related
genomes from 15 taxa representing all three domains of life (Bacteria, Archaea
and Eukaryota), and used phylogenies to polarize amino acid substitutions. Cys,
Met, His, Ser and Phe accrue in at least 14 taxa, whereas Pro, Ala, Glu and Gly
are consistently lost. The same nine amino acids are currently accrued or lost
in human proteins, as shown by analysis of non-synonymous single-nucleotide polymorphisms.
All amino acids with declining frequencies are thought to be among the first incorporated
into the genetic code; conversely, all amino acids with increasing frequencies,
except Ser, were probably recruited late. Thus, expansion of initially under-represented
amino acids, which began over 3,400 million years ago, apparently continues to
this day.
acknowledgement: S.S. and I.A.A. were supported by the Genome Canada Foundation.
author:
- first_name: Ingo
full_name: Jordan, Ingo K
last_name: Jordan
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Ivan
full_name: Adzhubeǐ, Ivan A
last_name: Adzhubeǐ
- first_name: Yuri
full_name: Wolf, Yuri I
last_name: Wolf
- first_name: Eugene
full_name: Koonin, Eugene V
last_name: Koonin
- first_name: Alexey
full_name: Kondrashov, Alexey S
last_name: Kondrashov
- first_name: Shamil
full_name: Sunyaev, Shamil R
last_name: Sunyaev
citation:
ama: Jordan I, Kondrashov F, Adzhubeǐ I, et al. A universal trend of amino acid
gain and loss in protein evolution. Nature. 2005;433(7026):633-638. doi:10.1038/nature03306
apa: Jordan, I., Kondrashov, F., Adzhubeǐ, I., Wolf, Y., Koonin, E., Kondrashov,
A., & Sunyaev, S. (2005). A universal trend of amino acid gain and loss in
protein evolution. Nature. Nature Publishing Group. https://doi.org/10.1038/nature03306
chicago: Jordan, Ingo, Fyodor Kondrashov, Ivan Adzhubeǐ, Yuri Wolf, Eugene Koonin,
Alexey Kondrashov, and Shamil Sunyaev. “A Universal Trend of Amino Acid Gain and
Loss in Protein Evolution.” Nature. Nature Publishing Group, 2005. https://doi.org/10.1038/nature03306.
ieee: I. Jordan et al., “A universal trend of amino acid gain and loss in
protein evolution,” Nature, vol. 433, no. 7026. Nature Publishing Group,
pp. 633–638, 2005.
ista: Jordan I, Kondrashov F, Adzhubeǐ I, Wolf Y, Koonin E, Kondrashov A, Sunyaev
S. 2005. A universal trend of amino acid gain and loss in protein evolution. Nature.
433(7026), 633–638.
mla: Jordan, Ingo, et al. “A Universal Trend of Amino Acid Gain and Loss in Protein
Evolution.” Nature, vol. 433, no. 7026, Nature Publishing Group, 2005,
pp. 633–38, doi:10.1038/nature03306.
short: I. Jordan, F. Kondrashov, I. Adzhubeǐ, Y. Wolf, E. Koonin, A. Kondrashov,
S. Sunyaev, Nature 433 (2005) 633–638.
date_created: 2018-12-11T11:49:03Z
date_published: 2005-02-10T00:00:00Z
date_updated: 2021-01-12T08:21:23Z
day: '10'
doi: 10.1038/nature03306
extern: 1
intvolume: ' 433'
issue: '7026'
month: '02'
page: 633 - 638
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '6757'
quality_controlled: 0
status: public
title: A universal trend of amino acid gain and loss in protein evolution
type: journal_article
volume: 433
year: '2005'
...
---
_id: '8028'
abstract:
- lang: eng
text: 'Transmission of signals within the brain is essential for cognitive function,
but it is not clear how neural circuits support reliable and accurate signal propagation
over a sufficiently large dynamic range. Two modes of propagation have been studied:
synfire chains, in which synchronous activity travels through feedforward layers
of a neuronal network, and the propagation of fluctuations in firing rate across
these layers. In both cases, a sufficient amount of noise, which was added to
previous models from an external source, had to be included to support stable
propagation. Sparse, randomly connected networks of spiking model neurons can
generate chaotic patterns of activity. We investigate whether this activity, which
is a more realistic noise source, is sufficient to allow for signal transmission.
We find that, for rate-coded signals but not for synfire chains, such networks
support robust and accurate signal reproduction through up to six layers if appropriate
adjustments are made in synaptic strengths. We investigate the factors affecting
transmission and show that multiple signals can propagate simultaneously along
different pathways. Using this feature, we show how different types of logic gates
can arise within the architecture of the random network through the strengthening
of specific synapses.'
article_processing_charge: No
article_type: original
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: L. F.
full_name: Abbott, L. F.
last_name: Abbott
citation:
ama: Vogels TP, Abbott LF. Signal propagation and logic gating in networks of integrate-and-fire
neurons. Journal of Neuroscience. 2005;25(46):10786-10795. doi:10.1523/jneurosci.3508-05.2005
apa: Vogels, T. P., & Abbott, L. F. (2005). Signal propagation and logic gating
in networks of integrate-and-fire neurons. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/jneurosci.3508-05.2005
chicago: Vogels, Tim P, and L. F. Abbott. “Signal Propagation and Logic Gating in
Networks of Integrate-and-Fire Neurons.” Journal of Neuroscience. Society
for Neuroscience, 2005. https://doi.org/10.1523/jneurosci.3508-05.2005.
ieee: T. P. Vogels and L. F. Abbott, “Signal propagation and logic gating in networks
of integrate-and-fire neurons,” Journal of Neuroscience, vol. 25, no. 46.
Society for Neuroscience, pp. 10786–10795, 2005.
ista: Vogels TP, Abbott LF. 2005. Signal propagation and logic gating in networks
of integrate-and-fire neurons. Journal of Neuroscience. 25(46), 10786–10795.
mla: Vogels, Tim P., and L. F. Abbott. “Signal Propagation and Logic Gating in Networks
of Integrate-and-Fire Neurons.” Journal of Neuroscience, vol. 25, no. 46,
Society for Neuroscience, 2005, pp. 10786–95, doi:10.1523/jneurosci.3508-05.2005.
short: T.P. Vogels, L.F. Abbott, Journal of Neuroscience 25 (2005) 10786–10795.
date_created: 2020-06-25T13:12:33Z
date_published: 2005-11-16T00:00:00Z
date_updated: 2021-01-12T08:16:37Z
day: '16'
doi: 10.1523/jneurosci.3508-05.2005
extern: '1'
external_id:
pmid:
- '16291952'
intvolume: ' 25'
issue: '46'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6725859/
month: '11'
oa: 1
oa_version: Published Version
page: 10786-10795
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
- 1529-2401
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
status: public
title: Signal propagation and logic gating in networks of integrate-and-fire neurons
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 25
year: '2005'
...
---
_id: '8029'
abstract:
- lang: eng
text: 'Neural network modeling is often concerned with stimulus-driven responses,
but most of the activity in the brain is internally generated. Here, we review
network models of internally generated activity, focusing on three types of network
dynamics: (a) sustained responses to transient stimuli, which provide a model
of working memory; (b) oscillatory network activity; and (c) chaotic activity,
which models complex patterns of background spiking in cortical and other circuits.
We also review propagation of stimulus-driven activity through spontaneously active
networks. Exploring these aspects of neural network dynamics is critical for understanding
how neural circuits produce cognitive function.'
article_processing_charge: No
article_type: review
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: Kanaka
full_name: Rajan, Kanaka
last_name: Rajan
- first_name: L.F.
full_name: Abbott, L.F.
last_name: Abbott
citation:
ama: Vogels TP, Rajan K, Abbott LF. Neural network dynamics. Annual Review of
Neuroscience. 2005;28(1):357-376. doi:10.1146/annurev.neuro.28.061604.135637
apa: Vogels, T. P., Rajan, K., & Abbott, L. F. (2005). Neural network dynamics.
Annual Review of Neuroscience. Annual Reviews. https://doi.org/10.1146/annurev.neuro.28.061604.135637
chicago: Vogels, Tim P, Kanaka Rajan, and L.F. Abbott. “Neural Network Dynamics.”
Annual Review of Neuroscience. Annual Reviews, 2005. https://doi.org/10.1146/annurev.neuro.28.061604.135637.
ieee: T. P. Vogels, K. Rajan, and L. F. Abbott, “Neural network dynamics,” Annual
Review of Neuroscience, vol. 28, no. 1. Annual Reviews, pp. 357–376, 2005.
ista: Vogels TP, Rajan K, Abbott LF. 2005. Neural network dynamics. Annual Review
of Neuroscience. 28(1), 357–376.
mla: Vogels, Tim P., et al. “Neural Network Dynamics.” Annual Review of Neuroscience,
vol. 28, no. 1, Annual Reviews, 2005, pp. 357–76, doi:10.1146/annurev.neuro.28.061604.135637.
short: T.P. Vogels, K. Rajan, L.F. Abbott, Annual Review of Neuroscience 28 (2005)
357–376.
date_created: 2020-06-25T13:13:11Z
date_published: 2005-07-21T00:00:00Z
date_updated: 2021-01-12T08:16:37Z
day: '21'
doi: 10.1146/annurev.neuro.28.061604.135637
extern: '1'
external_id:
pmid:
- '16022600'
intvolume: ' 28'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 357-376
pmid: 1
publication: Annual Review of Neuroscience
publication_identifier:
issn:
- 0147-006X
- 1545-4126
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
status: public
title: Neural network dynamics
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 28
year: '2005'
...
---
_id: '1740'
abstract:
- lang: eng
text: 'A systematic study of the morphology of self-organized islands in the InAs/GaAs(0
0 1) and Ge/Si(0 0 1) systems is presented, based on high-resolution scanning
tunneling microscopy measurements. We demonstrate that in both cases two main
island families coexist: smaller pyramids bound by one type of shallow facets
and larger multifaceted domes. Their structure and facet orientation are precisely
determined, thus solving a highly debated argument in the case of InAs/GaAs(0
0 1). The comparison between the two material systems reveals the existence of
striking similarities that extend even to the nature of island precursors and
to the islands that form when depositing InGaAs or GeSi alloys. The implications
of these observations on a possible universal description of the Stranski-Krastanow
growth mode are discussed with respect to recent theoretical results.'
author:
- first_name: Giovanni
full_name: Costantini, Giovanni
last_name: Costantini
- first_name: Armando
full_name: Rastelli, Armando
last_name: Rastelli
- first_name: Carlos
full_name: Manzano, Carlos
last_name: Manzano
- first_name: P
full_name: Acosta-Diaz, P
last_name: Acosta Diaz
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Rudeeson
full_name: Songmuang, Rudeeson
last_name: Songmuang
- first_name: Oliver
full_name: Schmidt, Oliver G
last_name: Schmidt
- first_name: Hans
full_name: Von Känel, Hans
last_name: Von Känel
- first_name: Klaus
full_name: Kern, Klaus
last_name: Kern
citation:
ama: Costantini G, Rastelli A, Manzano C, et al. Pyramids and domes in the InAs/GaAs
(0 0 1) and Ge/Si (0 0 1) systems. Journal of Crystal Growth. 2005;278(1-4):38-45.
doi:10.1016/j.jcrysgro.2004.12.047
apa: Costantini, G., Rastelli, A., Manzano, C., Acosta Diaz, P., Katsaros, G., Songmuang,
R., … Kern, K. (2005). Pyramids and domes in the InAs/GaAs (0 0 1) and Ge/Si (0
0 1) systems. Journal of Crystal Growth. Elsevier. https://doi.org/10.1016/j.jcrysgro.2004.12.047
chicago: Costantini, Giovanni, Armando Rastelli, Carlos Manzano, P Acosta Diaz,
Georgios Katsaros, Rudeeson Songmuang, Oliver Schmidt, Hans Von Känel, and Klaus
Kern. “Pyramids and Domes in the InAs/GaAs (0 0 1) and Ge/Si (0 0 1) Systems.”
Journal of Crystal Growth. Elsevier, 2005. https://doi.org/10.1016/j.jcrysgro.2004.12.047.
ieee: G. Costantini et al., “Pyramids and domes in the InAs/GaAs (0 0 1)
and Ge/Si (0 0 1) systems,” Journal of Crystal Growth, vol. 278, no. 1–4.
Elsevier, pp. 38–45, 2005.
ista: Costantini G, Rastelli A, Manzano C, Acosta Diaz P, Katsaros G, Songmuang
R, Schmidt O, Von Känel H, Kern K. 2005. Pyramids and domes in the InAs/GaAs (0
0 1) and Ge/Si (0 0 1) systems. Journal of Crystal Growth. 278(1–4), 38–45.
mla: Costantini, Giovanni, et al. “Pyramids and Domes in the InAs/GaAs (0 0 1) and
Ge/Si (0 0 1) Systems.” Journal of Crystal Growth, vol. 278, no. 1–4, Elsevier,
2005, pp. 38–45, doi:10.1016/j.jcrysgro.2004.12.047.
short: G. Costantini, A. Rastelli, C. Manzano, P. Acosta Diaz, G. Katsaros, R. Songmuang,
O. Schmidt, H. Von Känel, K. Kern, Journal of Crystal Growth 278 (2005) 38–45.
date_created: 2018-12-11T11:53:45Z
date_published: 2005-05-01T00:00:00Z
date_updated: 2021-01-12T06:52:54Z
day: '01'
doi: 10.1016/j.jcrysgro.2004.12.047
extern: 1
intvolume: ' 278'
issue: 1-4
month: '05'
page: 38 - 45
publication: Journal of Crystal Growth
publication_status: published
publisher: Elsevier
publist_id: '5384'
quality_controlled: 0
status: public
title: Pyramids and domes in the InAs/GaAs (0 0 1) and Ge/Si (0 0 1) systems
type: journal_article
volume: 278
year: '2005'
...
---
_id: '1741'
abstract:
- lang: eng
text: SiGe islands move laterally on a Si(001) substrate during in situ postgrowth
annealing. This surprising behavior is revealed by an analysis of the substrate
surface morphology after island removal using wet chemical etching. We explain
the island motion by asymmetric surface-mediated alloying. Material leaves one
side of the island by surface diffusion, and mixes with additional Si from the
surrounding surface as it redeposits on the other side. Thus the island moves
laterally while becoming larger and more dilute.
acknowledgement: The work was supported by the BMBF (03N8711)
author:
- first_name: Ulrich
full_name: Denker, Ulrich
last_name: Denker
- first_name: Armando
full_name: Rastelli, Armando
last_name: Rastelli
- first_name: Mathieu
full_name: Stoffel, Mathieu
last_name: Stoffel
- first_name: Jerry
full_name: Tersoff, Jerry
last_name: Tersoff
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Giovanni
full_name: Costantini, Giovanni
last_name: Costantini
- first_name: Klaus
full_name: Kern, Klaus
last_name: Kern
- first_name: Neng
full_name: Jin-Phillipp, Neng Y
last_name: Jin Phillipp
- first_name: David
full_name: Jesson, David E
last_name: Jesson
- first_name: Oliver
full_name: Schmidt, Oliver G
last_name: Schmidt
citation:
ama: Denker U, Rastelli A, Stoffel M, et al. Lateral motion of SiGe islands driven
by surface-mediated alloying. Physical Review Letters. 2005;94(21). doi:10.1103/PhysRevLett.94.216103
apa: Denker, U., Rastelli, A., Stoffel, M., Tersoff, J., Katsaros, G., Costantini,
G., … Schmidt, O. (2005). Lateral motion of SiGe islands driven by surface-mediated
alloying. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.94.216103
chicago: Denker, Ulrich, Armando Rastelli, Mathieu Stoffel, Jerry Tersoff, Georgios
Katsaros, Giovanni Costantini, Klaus Kern, Neng Jin Phillipp, David Jesson, and
Oliver Schmidt. “Lateral Motion of SiGe Islands Driven by Surface-Mediated Alloying.”
Physical Review Letters. American Physical Society, 2005. https://doi.org/10.1103/PhysRevLett.94.216103.
ieee: U. Denker et al., “Lateral motion of SiGe islands driven by surface-mediated
alloying,” Physical Review Letters, vol. 94, no. 21. American Physical
Society, 2005.
ista: Denker U, Rastelli A, Stoffel M, Tersoff J, Katsaros G, Costantini G, Kern
K, Jin Phillipp N, Jesson D, Schmidt O. 2005. Lateral motion of SiGe islands driven
by surface-mediated alloying. Physical Review Letters. 94(21).
mla: Denker, Ulrich, et al. “Lateral Motion of SiGe Islands Driven by Surface-Mediated
Alloying.” Physical Review Letters, vol. 94, no. 21, American Physical
Society, 2005, doi:10.1103/PhysRevLett.94.216103.
short: U. Denker, A. Rastelli, M. Stoffel, J. Tersoff, G. Katsaros, G. Costantini,
K. Kern, N. Jin Phillipp, D. Jesson, O. Schmidt, Physical Review Letters 94 (2005).
date_created: 2018-12-11T11:53:46Z
date_published: 2005-06-03T00:00:00Z
date_updated: 2021-01-12T06:52:54Z
day: '03'
doi: 10.1103/PhysRevLett.94.216103
extern: 1
intvolume: ' 94'
issue: '21'
month: '06'
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5383'
quality_controlled: 0
status: public
title: Lateral motion of SiGe islands driven by surface-mediated alloying
type: journal_article
volume: 94
year: '2005'
...
---
_id: '1742'
abstract:
- lang: eng
text: The effects of substrate temperature, growth rate, and postgrowth annealing
on the composition of Ge islands grown on Si(001) were investigated with a combination
of selective wet chemical etching and atomic force microscopy. A simple kinetic
model comprising only surface diffusion processes can explain all the experimentally
observed compositional profiles for pyramid and dome islands grown in the 560-620°C
range. From this model three-dimensional compositional maps were extracted. By
performing annealing experiments a change in the composition of the domes was
observed. This could be explained as the result of the islands' movement induced
by alloying-driven energy minimization. Also in this case kinetically hindered
bulk diffusion processes are not needed to explain the experimental observations.
acknowledgement: G. K. acknowledges the financial support of DAAD (Deutscher Akademischer
Austausch Dienst)
author:
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Giovanni
full_name: Costantini, Giovanni
last_name: Costantini
- first_name: Mathieu
full_name: Stoffel, Mathieu
last_name: Stoffel
- first_name: Rubén
full_name: Esteban, Rubén
last_name: Esteban
- first_name: Alexander
full_name: Bittner, Alexander M
last_name: Bittner
- first_name: Armando
full_name: Rastelli, Armando
last_name: Rastelli
- first_name: Ulrich
full_name: Denker, Ulrich
last_name: Denker
- first_name: Oliver
full_name: Schmidt, Oliver G
last_name: Schmidt
- first_name: Klaus
full_name: Kern, Klaus
last_name: Kern
citation:
ama: Katsaros G, Costantini G, Stoffel M, et al. Kinetic origin of island intermixing
during the growth of Ge on Si (001). Physical Review B - Condensed Matter and
Materials Physics. 2005;72(19). doi:10.1103/PhysRevB.72.195320
apa: Katsaros, G., Costantini, G., Stoffel, M., Esteban, R., Bittner, A., Rastelli,
A., … Kern, K. (2005). Kinetic origin of island intermixing during the growth
of Ge on Si (001). Physical Review B - Condensed Matter and Materials Physics.
American Physical Society. https://doi.org/10.1103/PhysRevB.72.195320
chicago: Katsaros, Georgios, Giovanni Costantini, Mathieu Stoffel, Rubén Esteban,
Alexander Bittner, Armando Rastelli, Ulrich Denker, Oliver Schmidt, and Klaus
Kern. “Kinetic Origin of Island Intermixing during the Growth of Ge on Si (001).”
Physical Review B - Condensed Matter and Materials Physics. American Physical
Society, 2005. https://doi.org/10.1103/PhysRevB.72.195320.
ieee: G. Katsaros et al., “Kinetic origin of island intermixing during the
growth of Ge on Si (001),” Physical Review B - Condensed Matter and Materials
Physics, vol. 72, no. 19. American Physical Society, 2005.
ista: Katsaros G, Costantini G, Stoffel M, Esteban R, Bittner A, Rastelli A, Denker
U, Schmidt O, Kern K. 2005. Kinetic origin of island intermixing during the growth
of Ge on Si (001). Physical Review B - Condensed Matter and Materials Physics.
72(19).
mla: Katsaros, Georgios, et al. “Kinetic Origin of Island Intermixing during the
Growth of Ge on Si (001).” Physical Review B - Condensed Matter and Materials
Physics, vol. 72, no. 19, American Physical Society, 2005, doi:10.1103/PhysRevB.72.195320.
short: G. Katsaros, G. Costantini, M. Stoffel, R. Esteban, A. Bittner, A. Rastelli,
U. Denker, O. Schmidt, K. Kern, Physical Review B - Condensed Matter and Materials
Physics 72 (2005).
date_created: 2018-12-11T11:53:46Z
date_published: 2005-11-15T00:00:00Z
date_updated: 2021-01-12T06:52:55Z
day: '15'
doi: 10.1103/PhysRevB.72.195320
extern: 1
intvolume: ' 72'
issue: '19'
month: '11'
publication: Physical Review B - Condensed Matter and Materials Physics
publication_status: published
publisher: American Physical Society
publist_id: '5382'
quality_controlled: 0
status: public
title: Kinetic origin of island intermixing during the growth of Ge on Si (001)
type: journal_article
volume: 72
year: '2005'
...