---
_id: '8488'
abstract:
- lang: eng
  text: We demonstrate for different protein samples that three-dimensional HNCO and
    HNCA correlation spectra may be recorded in a few minutes acquisition time using
    the band-selective excitation short-transient sequences presented here. This opens
    new perspectives for the NMR structural investigation of unstable protein samples
    and real-time site-resolved studies of protein kinetics.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Hélène
  full_name: Van Melckebeke, Hélène
  last_name: Van Melckebeke
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
citation:
  ama: Schanda P, Van Melckebeke H, Brutscher B. Speeding up three-dimensional protein
    NMR experiments to a few minutes. <i>Journal of the American Chemical Society</i>.
    2006;128(28):9042-9043. doi:<a href="https://doi.org/10.1021/ja062025p">10.1021/ja062025p</a>
  apa: Schanda, P., Van Melckebeke, H., &#38; Brutscher, B. (2006). Speeding up three-dimensional
    protein NMR experiments to a few minutes. <i>Journal of the American Chemical
    Society</i>. American Chemical Society. <a href="https://doi.org/10.1021/ja062025p">https://doi.org/10.1021/ja062025p</a>
  chicago: Schanda, Paul, Hélène Van Melckebeke, and Bernhard Brutscher. “Speeding
    up Three-Dimensional Protein NMR Experiments to a Few Minutes.” <i>Journal of
    the American Chemical Society</i>. American Chemical Society, 2006. <a href="https://doi.org/10.1021/ja062025p">https://doi.org/10.1021/ja062025p</a>.
  ieee: P. Schanda, H. Van Melckebeke, and B. Brutscher, “Speeding up three-dimensional
    protein NMR experiments to a few minutes,” <i>Journal of the American Chemical
    Society</i>, vol. 128, no. 28. American Chemical Society, pp. 9042–9043, 2006.
  ista: Schanda P, Van Melckebeke H, Brutscher B. 2006. Speeding up three-dimensional
    protein NMR experiments to a few minutes. Journal of the American Chemical Society.
    128(28), 9042–9043.
  mla: Schanda, Paul, et al. “Speeding up Three-Dimensional Protein NMR Experiments
    to a Few Minutes.” <i>Journal of the American Chemical Society</i>, vol. 128,
    no. 28, American Chemical Society, 2006, pp. 9042–43, doi:<a href="https://doi.org/10.1021/ja062025p">10.1021/ja062025p</a>.
  short: P. Schanda, H. Van Melckebeke, B. Brutscher, Journal of the American Chemical
    Society 128 (2006) 9042–9043.
date_created: 2020-09-18T10:13:36Z
date_published: 2006-06-21T00:00:00Z
date_updated: 2021-01-12T08:19:37Z
day: '21'
doi: 10.1021/ja062025p
extern: '1'
intvolume: '       128'
issue: '28'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '06'
oa_version: None
page: 9042-9043
publication: Journal of the American Chemical Society
publication_identifier:
  issn:
  - 0002-7863
  - 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Speeding up three-dimensional protein NMR experiments to a few minutes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2006'
...
---
_id: '8489'
abstract:
- lang: eng
  text: Structure elucidation of proteins by either NMR or X‐ray crystallography often
    requires the screening of a large number of samples for promising protein constructs
    and optimum solution conditions. For large‐scale screening of protein samples
    in solution, robust methods are needed that allow a rapid assessment of the folding
    of a polypeptide under diverse sample conditions. Here we present HET‐SOFAST NMR,
    a highly sensitive new method for semi‐quantitative characterization of the structural
    compactness and heterogeneity of polypeptide chains in solution. On the basis
    of one‐dimensional 1H HET‐SOFAST NMR data, obtained on well‐folded, molten globular,
    partially‐ and completely unfolded proteins, we define empirical thresholds that
    can be used as quantitative benchmarks for protein compactness. For 15N‐enriched
    protein samples, two‐dimensional 1H‐15N HET‐SOFAST correlation spectra provide
    site‐specific information about the structural heterogeneity along the polypeptide
    chain.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Vincent
  full_name: Forge, Vincent
  last_name: Forge
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
citation:
  ama: Schanda P, Forge V, Brutscher B. HET-SOFAST NMR for fast detection of structural
    compactness and heterogeneity along polypeptide chains. <i>Magnetic Resonance
    in Chemistry</i>. 2006;44(S1):S177-S184. doi:<a href="https://doi.org/10.1002/mrc.1825">10.1002/mrc.1825</a>
  apa: Schanda, P., Forge, V., &#38; Brutscher, B. (2006). HET-SOFAST NMR for fast
    detection of structural compactness and heterogeneity along polypeptide chains.
    <i>Magnetic Resonance in Chemistry</i>. Wiley. <a href="https://doi.org/10.1002/mrc.1825">https://doi.org/10.1002/mrc.1825</a>
  chicago: Schanda, Paul, Vincent Forge, and Bernhard Brutscher. “HET-SOFAST NMR for
    Fast Detection of Structural Compactness and Heterogeneity along Polypeptide Chains.”
    <i>Magnetic Resonance in Chemistry</i>. Wiley, 2006. <a href="https://doi.org/10.1002/mrc.1825">https://doi.org/10.1002/mrc.1825</a>.
  ieee: P. Schanda, V. Forge, and B. Brutscher, “HET-SOFAST NMR for fast detection
    of structural compactness and heterogeneity along polypeptide chains,” <i>Magnetic
    Resonance in Chemistry</i>, vol. 44, no. S1. Wiley, pp. S177–S184, 2006.
  ista: Schanda P, Forge V, Brutscher B. 2006. HET-SOFAST NMR for fast detection of
    structural compactness and heterogeneity along polypeptide chains. Magnetic Resonance
    in Chemistry. 44(S1), S177–S184.
  mla: Schanda, Paul, et al. “HET-SOFAST NMR for Fast Detection of Structural Compactness
    and Heterogeneity along Polypeptide Chains.” <i>Magnetic Resonance in Chemistry</i>,
    vol. 44, no. S1, Wiley, 2006, pp. S177–84, doi:<a href="https://doi.org/10.1002/mrc.1825">10.1002/mrc.1825</a>.
  short: P. Schanda, V. Forge, B. Brutscher, Magnetic Resonance in Chemistry 44 (2006)
    S177–S184.
date_created: 2020-09-18T10:13:42Z
date_published: 2006-07-06T00:00:00Z
date_updated: 2021-01-12T08:19:37Z
day: '06'
doi: 10.1002/mrc.1825
extern: '1'
intvolume: '        44'
issue: S1
language:
- iso: eng
month: '07'
oa_version: None
page: S177-S184
publication: Magnetic Resonance in Chemistry
publication_identifier:
  issn:
  - 0749-1581
  - 1097-458X
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: HET-SOFAST NMR for fast detection of structural compactness and heterogeneity
  along polypeptide chains
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 44
year: '2006'
...
---
_id: '8490'
abstract:
- lang: eng
  text: We demonstrate the feasibility of recording 1H–15N correlation spectra of
    proteins in only one second of acquisition time. The experiment combines recently
    proposed SOFAST-HMQC with Hadamard-type 15N frequency encoding. This allows site-resolved
    real-time NMR studies of kinetic processes in proteins with an increased time
    resolution. The sensitivity of the experiment is sufficient to be applicable to
    a wide range of molecular systems available at millimolar concentration on a high
    magnetic field spectrometer.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
citation:
  ama: Schanda P, Brutscher B. Hadamard frequency-encoded SOFAST-HMQC for ultrafast
    two-dimensional protein NMR. <i>Journal of Magnetic Resonance</i>. 2006;178(2):334-339.
    doi:<a href="https://doi.org/10.1016/j.jmr.2005.10.007">10.1016/j.jmr.2005.10.007</a>
  apa: Schanda, P., &#38; Brutscher, B. (2006). Hadamard frequency-encoded SOFAST-HMQC
    for ultrafast two-dimensional protein NMR. <i>Journal of Magnetic Resonance</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.jmr.2005.10.007">https://doi.org/10.1016/j.jmr.2005.10.007</a>
  chicago: Schanda, Paul, and Bernhard Brutscher. “Hadamard Frequency-Encoded SOFAST-HMQC
    for Ultrafast Two-Dimensional Protein NMR.” <i>Journal of Magnetic Resonance</i>.
    Elsevier, 2006. <a href="https://doi.org/10.1016/j.jmr.2005.10.007">https://doi.org/10.1016/j.jmr.2005.10.007</a>.
  ieee: P. Schanda and B. Brutscher, “Hadamard frequency-encoded SOFAST-HMQC for ultrafast
    two-dimensional protein NMR,” <i>Journal of Magnetic Resonance</i>, vol. 178,
    no. 2. Elsevier, pp. 334–339, 2006.
  ista: Schanda P, Brutscher B. 2006. Hadamard frequency-encoded SOFAST-HMQC for ultrafast
    two-dimensional protein NMR. Journal of Magnetic Resonance. 178(2), 334–339.
  mla: Schanda, Paul, and Bernhard Brutscher. “Hadamard Frequency-Encoded SOFAST-HMQC
    for Ultrafast Two-Dimensional Protein NMR.” <i>Journal of Magnetic Resonance</i>,
    vol. 178, no. 2, Elsevier, 2006, pp. 334–39, doi:<a href="https://doi.org/10.1016/j.jmr.2005.10.007">10.1016/j.jmr.2005.10.007</a>.
  short: P. Schanda, B. Brutscher, Journal of Magnetic Resonance 178 (2006) 334–339.
date_created: 2020-09-18T10:13:51Z
date_published: 2006-02-01T00:00:00Z
date_updated: 2021-01-12T08:19:38Z
day: '01'
doi: 10.1016/j.jmr.2005.10.007
extern: '1'
intvolume: '       178'
issue: '2'
keyword:
- Nuclear and High Energy Physics
- Biophysics
- Biochemistry
- Condensed Matter Physics
language:
- iso: eng
month: '02'
oa_version: None
page: 334-339
publication: Journal of Magnetic Resonance
publication_identifier:
  issn:
  - 1090-7807
publication_status: published
publisher: Elsevier
status: public
title: Hadamard frequency-encoded SOFAST-HMQC for ultrafast two-dimensional protein
  NMR
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 178
year: '2006'
...
---
_id: '8513'
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
- first_name: Maria
  full_name: Saprykina, Maria
  last_name: Saprykina
citation:
  ama: Kaloshin V, Saprykina M. Generic 3-dimensional volume-preserving diffeomorphisms
    with superexponential growth of number of periodic orbits. <i>Discrete &#38; Continuous
    Dynamical Systems - A</i>. 2006;15(2):611-640. doi:<a href="https://doi.org/10.3934/dcds.2006.15.611">10.3934/dcds.2006.15.611</a>
  apa: Kaloshin, V., &#38; Saprykina, M. (2006). Generic 3-dimensional volume-preserving
    diffeomorphisms with superexponential growth of number of periodic orbits. <i>Discrete
    &#38; Continuous Dynamical Systems - A</i>. American Institute of Mathematical
    Sciences (AIMS). <a href="https://doi.org/10.3934/dcds.2006.15.611">https://doi.org/10.3934/dcds.2006.15.611</a>
  chicago: Kaloshin, Vadim, and Maria Saprykina. “Generic 3-Dimensional Volume-Preserving
    Diffeomorphisms with Superexponential Growth of Number of Periodic Orbits.” <i>Discrete
    &#38; Continuous Dynamical Systems - A</i>. American Institute of Mathematical
    Sciences (AIMS), 2006. <a href="https://doi.org/10.3934/dcds.2006.15.611">https://doi.org/10.3934/dcds.2006.15.611</a>.
  ieee: V. Kaloshin and M. Saprykina, “Generic 3-dimensional volume-preserving diffeomorphisms
    with superexponential growth of number of periodic orbits,” <i>Discrete &#38;
    Continuous Dynamical Systems - A</i>, vol. 15, no. 2. American Institute of Mathematical
    Sciences (AIMS), pp. 611–640, 2006.
  ista: Kaloshin V, Saprykina M. 2006. Generic 3-dimensional volume-preserving diffeomorphisms
    with superexponential growth of number of periodic orbits. Discrete &#38; Continuous
    Dynamical Systems - A. 15(2), 611–640.
  mla: Kaloshin, Vadim, and Maria Saprykina. “Generic 3-Dimensional Volume-Preserving
    Diffeomorphisms with Superexponential Growth of Number of Periodic Orbits.” <i>Discrete
    &#38; Continuous Dynamical Systems - A</i>, vol. 15, no. 2, American Institute
    of Mathematical Sciences (AIMS), 2006, pp. 611–40, doi:<a href="https://doi.org/10.3934/dcds.2006.15.611">10.3934/dcds.2006.15.611</a>.
  short: V. Kaloshin, M. Saprykina, Discrete &#38; Continuous Dynamical Systems -
    A 15 (2006) 611–640.
date_created: 2020-09-18T10:48:43Z
date_published: 2006-05-01T00:00:00Z
date_updated: 2021-01-12T08:19:48Z
day: '01'
doi: 10.3934/dcds.2006.15.611
extern: '1'
intvolume: '        15'
issue: '2'
language:
- iso: eng
month: '05'
oa_version: None
page: 611-640
publication: Discrete & Continuous Dynamical Systems - A
publication_identifier:
  issn:
  - 1553-5231
publication_status: published
publisher: American Institute of Mathematical Sciences (AIMS)
quality_controlled: '1'
status: public
title: Generic 3-dimensional volume-preserving diffeomorphisms with superexponential
  growth of number of periodic orbits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2006'
...
---
_id: '8514'
abstract:
- lang: eng
  text: We study the extent to which the Hausdorff dimension of a compact subset of
    an infinite-dimensional Banach space is affected by a typical mapping into a finite-dimensional
    space. It is possible that the dimension drops under all such mappings, but the
    amount by which it typically drops is controlled by the ‘thickness exponent’ of
    the set, which was defined by Hunt and Kaloshin (Nonlinearity12 (1999), 1263–1275).
    More precisely, let $X$ be a compact subset of a Banach space $B$ with thickness
    exponent $\tau$ and Hausdorff dimension $d$. Let $M$ be any subspace of the (locally)
    Lipschitz functions from $B$ to $\mathbb{R}^{m}$ that contains the space of bounded
    linear functions. We prove that for almost every (in the sense of prevalence)
    function $f \in M$, the Hausdorff dimension of $f(X)$ is at least $\min\{ m, d
    / (1 + \tau) \}$. We also prove an analogous result for a certain part of the
    dimension spectra of Borel probability measures supported on $X$. The factor $1
    / (1 + \tau)$ can be improved to $1 / (1 + \tau / 2)$ if $B$ is a Hilbert space.
    Since dimension cannot increase under a (locally) Lipschitz function, these theorems
    become dimension preservation results when $\tau = 0$. We conjecture that many
    of the attractors associated with the evolution equations of mathematical physics
    have thickness exponent zero. We also discuss the sharpness of our results in
    the case $\tau > 0$.
article_processing_charge: No
article_type: original
author:
- first_name: WILLIAM
  full_name: OTT, WILLIAM
  last_name: OTT
- first_name: BRIAN
  full_name: HUNT, BRIAN
  last_name: HUNT
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
citation:
  ama: OTT W, HUNT B, Kaloshin V. The effect of projections on fractal sets and measures
    in Banach spaces. <i>Ergodic Theory and Dynamical Systems</i>. 2006;26(3):869-891.
    doi:<a href="https://doi.org/10.1017/s0143385705000714">10.1017/s0143385705000714</a>
  apa: OTT, W., HUNT, B., &#38; Kaloshin, V. (2006). The effect of projections on
    fractal sets and measures in Banach spaces. <i>Ergodic Theory and Dynamical Systems</i>.
    Cambridge University Press. <a href="https://doi.org/10.1017/s0143385705000714">https://doi.org/10.1017/s0143385705000714</a>
  chicago: OTT, WILLIAM, BRIAN HUNT, and Vadim Kaloshin. “The Effect of Projections
    on Fractal Sets and Measures in Banach Spaces.” <i>Ergodic Theory and Dynamical
    Systems</i>. Cambridge University Press, 2006. <a href="https://doi.org/10.1017/s0143385705000714">https://doi.org/10.1017/s0143385705000714</a>.
  ieee: W. OTT, B. HUNT, and V. Kaloshin, “The effect of projections on fractal sets
    and measures in Banach spaces,” <i>Ergodic Theory and Dynamical Systems</i>, vol.
    26, no. 3. Cambridge University Press, pp. 869–891, 2006.
  ista: OTT W, HUNT B, Kaloshin V. 2006. The effect of projections on fractal sets
    and measures in Banach spaces. Ergodic Theory and Dynamical Systems. 26(3), 869–891.
  mla: OTT, WILLIAM, et al. “The Effect of Projections on Fractal Sets and Measures
    in Banach Spaces.” <i>Ergodic Theory and Dynamical Systems</i>, vol. 26, no. 3,
    Cambridge University Press, 2006, pp. 869–91, doi:<a href="https://doi.org/10.1017/s0143385705000714">10.1017/s0143385705000714</a>.
  short: W. OTT, B. HUNT, V. Kaloshin, Ergodic Theory and Dynamical Systems 26 (2006)
    869–891.
date_created: 2020-09-18T10:48:52Z
date_published: 2006-06-01T00:00:00Z
date_updated: 2021-01-12T08:19:48Z
day: '01'
doi: 10.1017/s0143385705000714
extern: '1'
intvolume: '        26'
issue: '3'
language:
- iso: eng
month: '06'
oa_version: None
page: 869-891
publication: Ergodic Theory and Dynamical Systems
publication_identifier:
  issn:
  - 0143-3857
  - 1469-4417
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: The effect of projections on fractal sets and measures in Banach spaces
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2006'
...
---
_id: '8515'
abstract:
- lang: eng
  text: "We consider the evolution of a set carried by a space periodic incompressible
    stochastic flow in a Euclidean space. We\r\nreport on three main results obtained
    in [8, 9, 10] concerning long time behaviour for a typical realization of the
    stochastic flow. First, at time t most of the particles are at a distance of order
    √t away from the origin. Moreover, we prove a Central Limit Theorem for the evolution
    of a measure carried by the flow, which holds for almost every realization of
    the flow. Second, we show the existence of a zero measure full Hausdorff dimension
    set of points, which\r\nescape to infinity at a linear rate. Third, in the 2-dimensional
    case, we study the set of points visited by the original set by time t. Such a
    set, when scaled down by the factor of t, has a limiting non random shape."
article_processing_charge: No
author:
- first_name: Vadim
  full_name: Kaloshin, Vadim
  id: FE553552-CDE8-11E9-B324-C0EBE5697425
  last_name: Kaloshin
  orcid: 0000-0002-6051-2628
- first_name: D.
  full_name: DOLGOPYAT, D.
  last_name: DOLGOPYAT
- first_name: L.
  full_name: KORALOV, L.
  last_name: KORALOV
citation:
  ama: 'Kaloshin V, DOLGOPYAT D, KORALOV L. Long time behaviour of periodic stochastic
    flows. In: <i>XIVth International Congress on Mathematical Physics</i>. World
    Scientific; 2006:290-295. doi:<a href="https://doi.org/10.1142/9789812704016_0026">10.1142/9789812704016_0026</a>'
  apa: 'Kaloshin, V., DOLGOPYAT, D., &#38; KORALOV, L. (2006). Long time behaviour
    of periodic stochastic flows. In <i>XIVth International Congress on Mathematical
    Physics</i> (pp. 290–295). Lisbon, Portugal: World Scientific. <a href="https://doi.org/10.1142/9789812704016_0026">https://doi.org/10.1142/9789812704016_0026</a>'
  chicago: Kaloshin, Vadim, D. DOLGOPYAT, and L. KORALOV. “Long Time Behaviour of
    Periodic Stochastic Flows.” In <i>XIVth International Congress on Mathematical
    Physics</i>, 290–95. World Scientific, 2006. <a href="https://doi.org/10.1142/9789812704016_0026">https://doi.org/10.1142/9789812704016_0026</a>.
  ieee: V. Kaloshin, D. DOLGOPYAT, and L. KORALOV, “Long time behaviour of periodic
    stochastic flows,” in <i>XIVth International Congress on Mathematical Physics</i>,
    Lisbon, Portugal, 2006, pp. 290–295.
  ista: Kaloshin V, DOLGOPYAT D, KORALOV L. 2006. Long time behaviour of periodic
    stochastic flows. XIVth International Congress on Mathematical Physics. International
    Congress on Mathematical Physics, 290–295.
  mla: Kaloshin, Vadim, et al. “Long Time Behaviour of Periodic Stochastic Flows.”
    <i>XIVth International Congress on Mathematical Physics</i>, World Scientific,
    2006, pp. 290–95, doi:<a href="https://doi.org/10.1142/9789812704016_0026">10.1142/9789812704016_0026</a>.
  short: V. Kaloshin, D. DOLGOPYAT, L. KORALOV, in:, XIVth International Congress
    on Mathematical Physics, World Scientific, 2006, pp. 290–295.
conference:
  end_date: 2003-08-02
  location: Lisbon, Portugal
  name: International Congress on Mathematical Physics
  start_date: 2003-07-28
date_created: 2020-09-18T10:48:59Z
date_published: 2006-03-01T00:00:00Z
date_updated: 2021-01-12T08:19:49Z
day: '01'
doi: 10.1142/9789812704016_0026
extern: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: 290-295
publication: XIVth International Congress on Mathematical Physics
publication_identifier:
  isbn:
  - '9789812562012'
  - '9789812704016'
publication_status: published
publisher: World Scientific
quality_controlled: '1'
status: public
title: Long time behaviour of periodic stochastic flows
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2006'
...
---
_id: '854'
abstract:
- lang: eng
  text: Phylogenetic relationships between the extinct woolly mammoth (Mammuthus primigenius),
    and the Asian (Elephas maximus) and African savanna (Loxodonta africana) elephants
    remain unresolved. Here, we report the sequence of the complete mitochondrial
    genome (16,842 base pairs) of a woolly mammoth extracted from permafrost-preserved
    remains from the Pleistocene epoch - the oldest mitochondrial genome sequence
    determined to date. We demonstrate that well-preserved mitochondrial genome fragments,
    as long as ∼1,600-1700 base pairs, can be retrieved from pre-Holocene remains
    of an extinct species. Phylogenetic reconstruction of the Elephantinae clade suggests
    that M. primigenius and E. maximus are sister species that diverged soon after
    their common ancestor split from the L. africana lineage. Low nucleotide diversity
    found between independently determined mitochondrial genomic sequences of woolly
    mammoths separated geographically and in time suggests that north-eastern Siberia
    was occupied by a relatively homogeneous population of M. primigenius throughout
    the late Pleistocene.
acknowledgement: |-
  FAK is supported by the NSF Graduate Research Fellowship.
  We thank the Natural History Museum, North-Eastern Research Center, Far Eastern Branch of the Russian Academy of Sciences for photographic material ofM. primigenius leg, V. A. Nikishina for artwork and technical support, Y.B. Yurov, G. Dvoryanchikov, N. Riazanskaya and T. Kolesnikova for technical support, K. Mehren and C. Gray for elephant specimens, and V. Y. Solovyev for help with artwork of animal images.
author:
- first_name: Evgeny
  full_name: Rogaev, Evgeny I
  last_name: Rogaev
- first_name: Yuri
  full_name: Moliaka, Yuri K
  last_name: Moliaka
- first_name: Boris
  full_name: Malyarchuk, Boris A
  last_name: Malyarchuk
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Miroslava
  full_name: Derenko, Miroslava V
  last_name: Derenko
- first_name: Ilya
  full_name: Chumakov, Ilya M
  last_name: Chumakov
- first_name: Anastasia
  full_name: Grigorenko, Anastasia P
  last_name: Grigorenko
citation:
  ama: Rogaev E, Moliaka Y, Malyarchuk B, et al. Complete mitochondrial genome and
    phylogeny of pleistocene mammoth Mammuthus primigenius. <i>PLoS Biology</i>. 2006;4(3):0403-0410.
    doi:<a href="https://doi.org/10.1371/journal.pbio.0040073">10.1371/journal.pbio.0040073</a>
  apa: Rogaev, E., Moliaka, Y., Malyarchuk, B., Kondrashov, F., Derenko, M., Chumakov,
    I., &#38; Grigorenko, A. (2006). Complete mitochondrial genome and phylogeny of
    pleistocene mammoth Mammuthus primigenius. <i>PLoS Biology</i>. Public Library
    of Science. <a href="https://doi.org/10.1371/journal.pbio.0040073">https://doi.org/10.1371/journal.pbio.0040073</a>
  chicago: Rogaev, Evgeny, Yuri Moliaka, Boris Malyarchuk, Fyodor Kondrashov, Miroslava
    Derenko, Ilya Chumakov, and Anastasia Grigorenko. “Complete Mitochondrial Genome
    and Phylogeny of Pleistocene Mammoth Mammuthus Primigenius.” <i>PLoS Biology</i>.
    Public Library of Science, 2006. <a href="https://doi.org/10.1371/journal.pbio.0040073">https://doi.org/10.1371/journal.pbio.0040073</a>.
  ieee: E. Rogaev <i>et al.</i>, “Complete mitochondrial genome and phylogeny of pleistocene
    mammoth Mammuthus primigenius,” <i>PLoS Biology</i>, vol. 4, no. 3. Public Library
    of Science, pp. 0403–0410, 2006.
  ista: Rogaev E, Moliaka Y, Malyarchuk B, Kondrashov F, Derenko M, Chumakov I, Grigorenko
    A. 2006. Complete mitochondrial genome and phylogeny of pleistocene mammoth Mammuthus
    primigenius. PLoS Biology. 4(3), 0403–0410.
  mla: Rogaev, Evgeny, et al. “Complete Mitochondrial Genome and Phylogeny of Pleistocene
    Mammoth Mammuthus Primigenius.” <i>PLoS Biology</i>, vol. 4, no. 3, Public Library
    of Science, 2006, pp. 0403–10, doi:<a href="https://doi.org/10.1371/journal.pbio.0040073">10.1371/journal.pbio.0040073</a>.
  short: E. Rogaev, Y. Moliaka, B. Malyarchuk, F. Kondrashov, M. Derenko, I. Chumakov,
    A. Grigorenko, PLoS Biology 4 (2006) 0403–0410.
date_created: 2018-12-11T11:48:51Z
date_published: 2006-03-01T00:00:00Z
date_updated: 2021-01-12T08:19:58Z
day: '01'
doi: 10.1371/journal.pbio.0040073
extern: 1
intvolume: '         4'
issue: '3'
month: '03'
page: 0403 - 0410
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6794'
quality_controlled: 0
status: public
title: Complete mitochondrial genome and phylogeny of pleistocene mammoth Mammuthus
  primigenius
type: journal_article
volume: 4
year: '2006'
...
---
_id: '868'
abstract:
- lang: eng
  text: 'Background: The glyoxylate cycle is thought to be present in bacteria, protists,
    plants, fungi, and nematodes, but not in other Metazoa. However, activity of the
    glyoxylate cycle enzymes, malate synthase (MS) and isocitrate lyase (ICL), in
    animal tissues has been reported. In order to clarify the status of the MS and
    ICL genes in animals and get an insight into their evolution, we undertook a comparative-genomic
    study. Results: Using sequence similarity searches, we identified MS genes in
    arthropods, echinoderms, and vertebrates, including platypus and opossum, but
    not in the numerous sequenced genomes of placental mammals. The regions of the
    placental mammals'' genomes expected to code for malate synthase, as determined
    by comparison of the gene orders in vertebrate genomes, show clear similarity
    to the opossum MS sequence but contain stop codons, indicating that the MS gene
    became a pseudogene in placental mammals. By contrast, the ICL gene is undetectable
    in animals other than the nematodes that possess a bifunctional, fused ICL-MS
    gene. Examination of phylogenetic trees of MS and ICL suggests multiple horizontal
    gene transfer events that probably went in both directions between several bacterial
    and eukaryotic lineages. The strongest evidence was obtained for the acquisition
    of the bifunctional ICL-MS gene from an as yet unknown bacterial source with the
    corresponding operonic organization by the common ancestor of the nematodes. Conclusion:
    The distribution of the MS and ICL genes in animals suggests that either they
    encode alternative enzymes of the glyoxylate cycle that are not orthologous to
    the known MS and ICL or the animal MS acquired a new function that remains to
    be characterized. Regardless of the ultimate solution to this conundrum, the genes
    for the glyoxylate cycle enzymes present a remarkable variety of evolutionary
    events including unusual horizontal gene transfer from bacteria to animals.'
acknowledgement: The authors thank Alexey Kondrashov for suggesting the possibility
  of non- orthologous gene displacement in glyoxylate cycle specific enzymes and for
  critical reading of this manuscript. FAK is a National Science Foundation Graduate
  Fellow.
author:
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Eugene
  full_name: Koonin, Eugene V
  last_name: Koonin
- first_name: Igor
  full_name: Morgunov, Igor G
  last_name: Morgunov
- first_name: Tatiana
  full_name: Finogenova, Tatiana V
  last_name: Finogenova
- first_name: Marie
  full_name: Kondrashova, Marie N
  last_name: Kondrashova
citation:
  ama: Kondrashov F, Koonin E, Morgunov I, Finogenova T, Kondrashova M. Evolution
    of glyoxylate cycle enzymes in Metazoa Evidence of multiple horizontal transfer
    events and pseudogene formation. <i>Biology Direct</i>. 2006;1. doi:<a href="https://doi.org/10.1186/1745-6150-1-31">10.1186/1745-6150-1-31</a>
  apa: Kondrashov, F., Koonin, E., Morgunov, I., Finogenova, T., &#38; Kondrashova,
    M. (2006). Evolution of glyoxylate cycle enzymes in Metazoa Evidence of multiple
    horizontal transfer events and pseudogene formation. <i>Biology Direct</i>. BioMed
    Central. <a href="https://doi.org/10.1186/1745-6150-1-31">https://doi.org/10.1186/1745-6150-1-31</a>
  chicago: Kondrashov, Fyodor, Eugene Koonin, Igor Morgunov, Tatiana Finogenova, and
    Marie Kondrashova. “Evolution of Glyoxylate Cycle Enzymes in Metazoa Evidence
    of Multiple Horizontal Transfer Events and Pseudogene Formation.” <i>Biology Direct</i>.
    BioMed Central, 2006. <a href="https://doi.org/10.1186/1745-6150-1-31">https://doi.org/10.1186/1745-6150-1-31</a>.
  ieee: F. Kondrashov, E. Koonin, I. Morgunov, T. Finogenova, and M. Kondrashova,
    “Evolution of glyoxylate cycle enzymes in Metazoa Evidence of multiple horizontal
    transfer events and pseudogene formation,” <i>Biology Direct</i>, vol. 1. BioMed
    Central, 2006.
  ista: Kondrashov F, Koonin E, Morgunov I, Finogenova T, Kondrashova M. 2006. Evolution
    of glyoxylate cycle enzymes in Metazoa Evidence of multiple horizontal transfer
    events and pseudogene formation. Biology Direct. 1.
  mla: Kondrashov, Fyodor, et al. “Evolution of Glyoxylate Cycle Enzymes in Metazoa
    Evidence of Multiple Horizontal Transfer Events and Pseudogene Formation.” <i>Biology
    Direct</i>, vol. 1, BioMed Central, 2006, doi:<a href="https://doi.org/10.1186/1745-6150-1-31">10.1186/1745-6150-1-31</a>.
  short: F. Kondrashov, E. Koonin, I. Morgunov, T. Finogenova, M. Kondrashova, Biology
    Direct 1 (2006).
date_created: 2018-12-11T11:48:56Z
date_published: 2006-10-23T00:00:00Z
date_updated: 2021-01-12T08:20:31Z
day: '23'
doi: 10.1186/1745-6150-1-31
extern: 1
intvolume: '         1'
month: '10'
publication: Biology Direct
publication_status: published
publisher: BioMed Central
publist_id: '6778'
quality_controlled: 0
status: public
title: Evolution of glyoxylate cycle enzymes in Metazoa Evidence of multiple horizontal
  transfer events and pseudogene formation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 1
year: '2006'
...
---
_id: '869'
abstract:
- lang: eng
  text: The impact of synonymous nucleotide substitutions on fitness in mammals remains
    controversial. Despite some indications of selective constraint, synonymous sites
    are often assumed to be neutral, and the rate of their evolution is used as a
    proxy for mutation rate. We subdivide all sites into four classes in terms of
    the mutable CpG context, nonCpG, postC, preG, and postCpreG, and compare four-fold
    synonymous sites and intron sites residing outside transposable elements. The
    distribution of the rate of evolution across all synonymous sites is trimodal.
    Rate of evolution at nonCpG synonymous sites, not preceded by C and not followed
    by G, is ∼10% below that at such intron sites. In contrast, rate of evolution
    at postCpreG synonymous sites is ∼30% above that at such intron sites. Finally,
    synonymous and intron postC and preG sites evolve at similar rates. The relationship
    between the levels of polymorphism at the corresponding synonymous and intron
    sites is very similar to that between their rates of evolution. Within every class,
    synonymous sites are occupied by G or C much more often than intron sites, whose
    nucleotide composition is consistent with neutral mutation-drift equilibrium.
    These patterns suggest that synonymous sites are under weak selection in favor
    of G and C, with the average coefficient s∼0.25/Ne∼10-5, where Ne is the effective
    population size. Such selection decelerates evolution and reduces variability
    at sites with symmetric mutation, but has the opposite effects at sites where
    the favored nucleotides are more mutable. The amino-acid composition of proteins
    dictates that many synonymous sites are CpGprone, which causes them, on average,
    to evolve faster and to be more polymorphic than intron sites. An average genotype
    carries ∼107 suboptimal nucleotides at synonymous sites, implying synergistic
    epistasis in selection against them.
acknowledgement: This research was supported in part by the Intramural Research Program
  of the NIH, National Library of Medicine.
author:
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Aleksey
  full_name: Ogurtsov, Aleksey Yu
  last_name: Ogurtsov
- first_name: Alexey
  full_name: Kondrashov, Alexey S
  last_name: Kondrashov
citation:
  ama: Kondrashov F, Ogurtsov A, Kondrashov A. Selection in favor of nucleotides G
    and C diversifies evolution rates and levels of polymorphism at mammalian synonymous
    sites. <i>Journal of Theoretical Biology</i>. 2006;240(4):616-626. doi:<a href="https://doi.org/10.1016/j.jtbi.2005.10.020">10.1016/j.jtbi.2005.10.020</a>
  apa: Kondrashov, F., Ogurtsov, A., &#38; Kondrashov, A. (2006). Selection in favor
    of nucleotides G and C diversifies evolution rates and levels of polymorphism
    at mammalian synonymous sites. <i>Journal of Theoretical Biology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.jtbi.2005.10.020">https://doi.org/10.1016/j.jtbi.2005.10.020</a>
  chicago: Kondrashov, Fyodor, Aleksey Ogurtsov, and Alexey Kondrashov. “Selection
    in Favor of Nucleotides G and C Diversifies Evolution Rates and Levels of Polymorphism
    at Mammalian Synonymous Sites.” <i>Journal of Theoretical Biology</i>. Elsevier,
    2006. <a href="https://doi.org/10.1016/j.jtbi.2005.10.020">https://doi.org/10.1016/j.jtbi.2005.10.020</a>.
  ieee: F. Kondrashov, A. Ogurtsov, and A. Kondrashov, “Selection in favor of nucleotides
    G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous
    sites,” <i>Journal of Theoretical Biology</i>, vol. 240, no. 4. Elsevier, pp.
    616–626, 2006.
  ista: Kondrashov F, Ogurtsov A, Kondrashov A. 2006. Selection in favor of nucleotides
    G and C diversifies evolution rates and levels of polymorphism at mammalian synonymous
    sites. Journal of Theoretical Biology. 240(4), 616–626.
  mla: Kondrashov, Fyodor, et al. “Selection in Favor of Nucleotides G and C Diversifies
    Evolution Rates and Levels of Polymorphism at Mammalian Synonymous Sites.” <i>Journal
    of Theoretical Biology</i>, vol. 240, no. 4, Elsevier, 2006, pp. 616–26, doi:<a
    href="https://doi.org/10.1016/j.jtbi.2005.10.020">10.1016/j.jtbi.2005.10.020</a>.
  short: F. Kondrashov, A. Ogurtsov, A. Kondrashov, Journal of Theoretical Biology
    240 (2006) 616–626.
date_created: 2018-12-11T11:48:56Z
date_published: 2006-06-21T00:00:00Z
date_updated: 2021-01-12T08:20:33Z
day: '21'
doi: 10.1016/j.jtbi.2005.10.020
extern: 1
intvolume: '       240'
issue: '4'
month: '06'
page: 616 - 626
publication: Journal of Theoretical Biology
publication_status: published
publisher: Elsevier
publist_id: '6779'
quality_controlled: 0
status: public
title: Selection in favor of nucleotides G and C diversifies evolution rates and levels
  of polymorphism at mammalian synonymous sites
type: journal_article
volume: 240
year: '2006'
...
---
_id: '873'
abstract:
- lang: eng
  text: New genes commonly appear through complete or partial duplications of pre-existing
    genes. Duplications of long DNA segments are constantly produced by rare mutations,
    may become fixed in a population by selection or random drift, and are subject
    to divergent evolution of the paralogous sequences after fixation, although gene
    conversion can impede this process. New data shed some light on each of these
    processes. Mutations which involve duplications can occur through at least two
    different mechanisms, backward strand slippage during DNA replication and unequal
    crossing-over. The background rate of duplication of a complete gene in humans
    is 10-9-10-10 per generation, although many genes located within hot-spots of
    large-scale mutation are duplicated much more often. Many gene duplications affect
    fitness strongly, and are responsible, through gene dosage effects, for a number
    of genetic diseases. However, high levels of intrapopulation polymorphism caused
    by presence or absence of long, gene-containing DNA segments imply that some duplications
    are not under strong selection. The polymorphism to fixation ratios appear to
    be approximately the same for gene duplications and for presumably selectively
    neutral nucleotide substitutions, which, according to the McDonald-Kreitman test,
    is consistent with selective neutrality of duplications. However, this pattern
    can also be due to negative selection against most of segregating duplications
    and positive selection for at least some duplications which become fixed. Patterns
    in post-fixation evolution of duplicated genes do not easily reveal the causes
    of fixations. Many gene duplications which became fixed recently in a variety
    of organisms were positively selected because the increased expression of the
    corresponding genes was beneficial. The effects of gene dosage provide a unified
    framework for studying all phases of the life history of a gene duplication. Application
    of well-known methods of evolutionary genetics to accumulating data on new, polymorphic,
    and fixed duplication will enhance our understanding of the role of natural selection
    in the evolution by gene duplication.
author:
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Alexey
  full_name: Kondrashov, Alexey S
  last_name: Kondrashov
citation:
  ama: Kondrashov F, Kondrashov A. Role of selection in fixation of gene duplications.
    <i>Journal of Theoretical Biology</i>. 2006;239(2):141-151. doi:<a href="https://doi.org/10.1016/j.jtbi.2005.08.033">10.1016/j.jtbi.2005.08.033</a>
  apa: Kondrashov, F., &#38; Kondrashov, A. (2006). Role of selection in fixation
    of gene duplications. <i>Journal of Theoretical Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jtbi.2005.08.033">https://doi.org/10.1016/j.jtbi.2005.08.033</a>
  chicago: Kondrashov, Fyodor, and Alexey Kondrashov. “Role of Selection in Fixation
    of Gene Duplications.” <i>Journal of Theoretical Biology</i>. Elsevier, 2006.
    <a href="https://doi.org/10.1016/j.jtbi.2005.08.033">https://doi.org/10.1016/j.jtbi.2005.08.033</a>.
  ieee: F. Kondrashov and A. Kondrashov, “Role of selection in fixation of gene duplications,”
    <i>Journal of Theoretical Biology</i>, vol. 239, no. 2. Elsevier, pp. 141–151,
    2006.
  ista: Kondrashov F, Kondrashov A. 2006. Role of selection in fixation of gene duplications.
    Journal of Theoretical Biology. 239(2), 141–151.
  mla: Kondrashov, Fyodor, and Alexey Kondrashov. “Role of Selection in Fixation of
    Gene Duplications.” <i>Journal of Theoretical Biology</i>, vol. 239, no. 2, Elsevier,
    2006, pp. 141–51, doi:<a href="https://doi.org/10.1016/j.jtbi.2005.08.033">10.1016/j.jtbi.2005.08.033</a>.
  short: F. Kondrashov, A. Kondrashov, Journal of Theoretical Biology 239 (2006) 141–151.
date_created: 2018-12-11T11:48:57Z
date_published: 2006-03-21T00:00:00Z
date_updated: 2021-01-12T08:20:47Z
day: '21'
doi: 10.1016/j.jtbi.2005.08.033
extern: 1
intvolume: '       239'
issue: '2'
month: '03'
page: 141 - 151
publication: Journal of Theoretical Biology
publication_status: published
publisher: Elsevier
publist_id: '6773'
quality_controlled: 0
status: public
title: Role of selection in fixation of gene duplications
type: journal_article
volume: 239
year: '2006'
...
---
_id: '903'
abstract:
- lang: eng
  text: 'Background: Carcinogenesis typically involves multiple somatic mutations
    in caretaker (DNA repair) and gatekeeper (tumor suppressors and oncogenes) genes.
    Analysis of mutation spectra of the tumor suppressor that is most commonly mutated
    in human cancers, p53, unexpectedly suggested that somatic evolution of the p53
    gene during tumorigenesis is dominated by positive selection for gain of function.
    This conclusion is supported by accumulating experimental evidence of evolution
    of new functions of p53 in tumors. These findings prompted a genome-wide analysis
    of possible positive selection during tumor evolution. Methods: A comprehensive
    analysis of probable somatic mutations in the sequences of Expressed Sequence
    Tags (ESTs) from malignant tumors and normal tissues was performed in order to
    access the prevalence of positive selection in cancer evolution. For each EST,
    the numbers of synonymous and non-synonymous substitutions were calculated. In
    order to identify genes with a signature of positive selection in cancers, these
    numbers were compared to: i) expected numbers and ii) the numbers for the respective
    genes in the ESTs from normal tissues. Results: We identified 112 genes with a
    signature of positive selection in cancers, i.e., a significantly elevated ratio
    of non-synonymous to synonymous substitutions, in tumors as compared to 37 such
    genes in an approximately equal-sized EST collection from normal tissues. A substantial
    fraction of the tumor-specific positive-selection candidates have experimentally
    demonstrated or strongly predicted links to cancer. Conclusion: The results of
    EST analysis should be interpreted with extreme caution given the noise introduced
    by sequencing errors and undetected polymorphisms. Furthermore, an inherent limitation
    of EST analysis is that multiple mutations amenable to statistical analysis can
    be detected only in relatively highly expressed genes. Nevertheless, the present
    results suggest that positive selection might affect a substantial number of genes
    during tumorigenic somatic evolution.'
acknowledgement: This work was supported by the Intramural Research Program of the
  National Library of Medicine at the National Institutes of Health/DHHS. FAK is an
  NSF Graduate Fellow. We thank Yuri Pavlov for helpful discussions.
author:
- first_name: Vladimir
  full_name: Babenko, Vladimir N
  last_name: Babenko
- first_name: Malay
  full_name: Basu, Malay K
  last_name: Basu
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Igor
  full_name: Rogozin, Igor B
  last_name: Rogozin
- first_name: Eugene
  full_name: Koonin, Eugene V
  last_name: Koonin
citation:
  ama: Babenko V, Basu M, Kondrashov F, Rogozin I, Koonin E. Signs of positive selection
    of somatic mutations in human cancers detected by EST sequence analysis. <i>BMC
    Cancer</i>. 2006;6. doi:<a href="https://doi.org/10.1186/1471-2407-6-36">10.1186/1471-2407-6-36</a>
  apa: Babenko, V., Basu, M., Kondrashov, F., Rogozin, I., &#38; Koonin, E. (2006).
    Signs of positive selection of somatic mutations in human cancers detected by
    EST sequence analysis. <i>BMC Cancer</i>. BioMed Central. <a href="https://doi.org/10.1186/1471-2407-6-36">https://doi.org/10.1186/1471-2407-6-36</a>
  chicago: Babenko, Vladimir, Malay Basu, Fyodor Kondrashov, Igor Rogozin, and Eugene
    Koonin. “Signs of Positive Selection of Somatic Mutations in Human Cancers Detected
    by EST Sequence Analysis.” <i>BMC Cancer</i>. BioMed Central, 2006. <a href="https://doi.org/10.1186/1471-2407-6-36">https://doi.org/10.1186/1471-2407-6-36</a>.
  ieee: V. Babenko, M. Basu, F. Kondrashov, I. Rogozin, and E. Koonin, “Signs of positive
    selection of somatic mutations in human cancers detected by EST sequence analysis,”
    <i>BMC Cancer</i>, vol. 6. BioMed Central, 2006.
  ista: Babenko V, Basu M, Kondrashov F, Rogozin I, Koonin E. 2006. Signs of positive
    selection of somatic mutations in human cancers detected by EST sequence analysis.
    BMC Cancer. 6.
  mla: Babenko, Vladimir, et al. “Signs of Positive Selection of Somatic Mutations
    in Human Cancers Detected by EST Sequence Analysis.” <i>BMC Cancer</i>, vol. 6,
    BioMed Central, 2006, doi:<a href="https://doi.org/10.1186/1471-2407-6-36">10.1186/1471-2407-6-36</a>.
  short: V. Babenko, M. Basu, F. Kondrashov, I. Rogozin, E. Koonin, BMC Cancer 6 (2006).
date_created: 2018-12-11T11:49:07Z
date_published: 2006-02-09T00:00:00Z
date_updated: 2021-01-12T08:21:47Z
day: '09'
doi: 10.1186/1471-2407-6-36
extern: 1
intvolume: '         6'
month: '02'
publication: BMC Cancer
publication_status: published
publisher: BioMed Central
publist_id: '6744'
quality_controlled: 0
status: public
title: Signs of positive selection of somatic mutations in human cancers detected
  by EST sequence analysis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 6
year: '2006'
...
---
_id: '7326'
abstract:
- lang: eng
  text: 'Often the properties of a single cell are considered as representative for
    a complete polymer electrolyte fuel cell stack or even a fuel cell system. In
    some cases this comes close, however, in many real cases differences on several
    scales become important. Cell interaction phenomena in fuel cell stacks that arise
    from inequalities between adjacent cells are investigated in detail experimentally.
    For that, a specialized 2-cell stack with advanced localized diagnostics was developed.
    The results show that inequalities propagate by electrical coupling, inhomogeneous
    cell polarization and inducing in-plane current in the common bipolar plate. The
    effects of the different loss-mechanisms are analyzed and quantified. '
article_processing_charge: No
author:
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Marco
  full_name: Santis, Marco
  last_name: Santis
citation:
  ama: 'Büchi FN, Freunberger SA, Santis M. What is learned beyond the scale of single
    cells? In: <i>ECS Transactions</i>. Vol 3. ECS; 2006:963-968. doi:<a href="https://doi.org/10.1149/1.2356215">10.1149/1.2356215</a>'
  apa: 'Büchi, F. N., Freunberger, S. A., &#38; Santis, M. (2006). What is learned
    beyond the scale of single cells? In <i>ECS Transactions</i> (Vol. 3, pp. 963–968).
    Cancun, Mexico: ECS. <a href="https://doi.org/10.1149/1.2356215">https://doi.org/10.1149/1.2356215</a>'
  chicago: Büchi, Felix N., Stefan Alexander Freunberger, and Marco Santis. “What
    Is Learned beyond the Scale of Single Cells?” In <i>ECS Transactions</i>, 3:963–68.
    ECS, 2006. <a href="https://doi.org/10.1149/1.2356215">https://doi.org/10.1149/1.2356215</a>.
  ieee: F. N. Büchi, S. A. Freunberger, and M. Santis, “What is learned beyond the
    scale of single cells?,” in <i>ECS Transactions</i>, Cancun, Mexico, 2006, vol.
    3, no. 1, pp. 963–968.
  ista: Büchi FN, Freunberger SA, Santis M. 2006. What is learned beyond the scale
    of single cells? ECS Transactions. ECS Meeting vol. 3, 963–968.
  mla: Büchi, Felix N., et al. “What Is Learned beyond the Scale of Single Cells?”
    <i>ECS Transactions</i>, vol. 3, no. 1, ECS, 2006, pp. 963–68, doi:<a href="https://doi.org/10.1149/1.2356215">10.1149/1.2356215</a>.
  short: F.N. Büchi, S.A. Freunberger, M. Santis, in:, ECS Transactions, ECS, 2006,
    pp. 963–968.
conference:
  end_date: 2006-11-03
  location: Cancun, Mexico
  name: ECS Meeting
  start_date: 2006-10-29
date_created: 2020-01-15T12:22:44Z
date_published: 2006-11-03T00:00:00Z
date_updated: 2021-01-12T08:13:05Z
day: '03'
doi: 10.1149/1.2356215
extern: '1'
intvolume: '         3'
issue: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 963-968
publication: ECS Transactions
publication_status: published
publisher: ECS
quality_controlled: '1'
status: public
title: What is learned beyond the scale of single cells?
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2006'
...
---
_id: '7327'
abstract:
- lang: eng
  text: "Propagation of performance changes to adjacent cells in polymer electrolyte
    fuel cell stacks is studied by means of voltage monitoring and local current density
    measurements in peripheral cells of the stack. A technical fuel cell stack has
    been modified by implementing two independent reactant and coolant supplies in
    order to deliberately change the performance of one cell (anomalous cell) and
    study the coupling phenomena to adjacent cells (coupling cells), while keeping
    the working conditions of the later cell-group unaltered.\r\nTwo anomalies are
    studied: (i) air starvation and (ii) thermal anomaly, in a single anomalous cell
    in the stack and their coupling to adjacent cells. The results have shown that
    anomalies inducing considerable changes in the local current density of the anomalous
    cell (such as air starvation) propagate to adjacent cells affecting their performance.
    The propagation of local current density changes takes place via the common bipolar
    plate due to its finite thickness and in-plane conductivity. Consequently, anomalies
    which do not strongly influence the local current density distribution (such as
    a thermal anomaly under the studied working conditions) do not propagate to adjacent
    cells."
article_processing_charge: No
article_type: original
author:
- first_name: Marco
  full_name: Santis, Marco
  last_name: Santis
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Matthias
  full_name: Papra, Matthias
  last_name: Papra
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Santis M, Freunberger SA, Papra M, Wokaun A, Büchi FN. Experimental investigation
    of coupling phenomena in polymer electrolyte fuel cell stacks. <i>Journal of Power
    Sources</i>. 2006;161(2):1076-1083. doi:<a href="https://doi.org/10.1016/j.jpowsour.2006.06.007">10.1016/j.jpowsour.2006.06.007</a>
  apa: Santis, M., Freunberger, S. A., Papra, M., Wokaun, A., &#38; Büchi, F. N. (2006).
    Experimental investigation of coupling phenomena in polymer electrolyte fuel cell
    stacks. <i>Journal of Power Sources</i>. Elsevier. <a href="https://doi.org/10.1016/j.jpowsour.2006.06.007">https://doi.org/10.1016/j.jpowsour.2006.06.007</a>
  chicago: Santis, Marco, Stefan Alexander Freunberger, Matthias Papra, Alexander
    Wokaun, and Felix N. Büchi. “Experimental Investigation of Coupling Phenomena
    in Polymer Electrolyte Fuel Cell Stacks.” <i>Journal of Power Sources</i>. Elsevier,
    2006. <a href="https://doi.org/10.1016/j.jpowsour.2006.06.007">https://doi.org/10.1016/j.jpowsour.2006.06.007</a>.
  ieee: M. Santis, S. A. Freunberger, M. Papra, A. Wokaun, and F. N. Büchi, “Experimental
    investigation of coupling phenomena in polymer electrolyte fuel cell stacks,”
    <i>Journal of Power Sources</i>, vol. 161, no. 2. Elsevier, pp. 1076–1083, 2006.
  ista: Santis M, Freunberger SA, Papra M, Wokaun A, Büchi FN. 2006. Experimental
    investigation of coupling phenomena in polymer electrolyte fuel cell stacks. Journal
    of Power Sources. 161(2), 1076–1083.
  mla: Santis, Marco, et al. “Experimental Investigation of Coupling Phenomena in
    Polymer Electrolyte Fuel Cell Stacks.” <i>Journal of Power Sources</i>, vol. 161,
    no. 2, Elsevier, 2006, pp. 1076–83, doi:<a href="https://doi.org/10.1016/j.jpowsour.2006.06.007">10.1016/j.jpowsour.2006.06.007</a>.
  short: M. Santis, S.A. Freunberger, M. Papra, A. Wokaun, F.N. Büchi, Journal of
    Power Sources 161 (2006) 1076–1083.
date_created: 2020-01-15T12:22:56Z
date_published: 2006-10-27T00:00:00Z
date_updated: 2021-01-12T08:13:06Z
day: '27'
doi: 10.1016/j.jpowsour.2006.06.007
extern: '1'
intvolume: '       161'
issue: '2'
language:
- iso: eng
month: '10'
oa_version: None
page: 1076-1083
publication: Journal of Power Sources
publication_identifier:
  issn:
  - 0378-7753
publication_status: published
publisher: Elsevier
status: public
title: Experimental investigation of coupling phenomena in polymer electrolyte fuel
  cell stacks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 161
year: '2006'
...
---
_id: '7328'
abstract:
- lang: eng
  text: An experimental technique for measuring the current density distribution with
    a resolution smaller than the channel/rib scale of the flow field in polymer electrolyte
    fuel cells (PEFCs) is presented. The electron conductors in a plane perpendicular
    to the channel direction are considered as two-dimensional resistors. Hence, the
    current density is obtained from the solution of Laplace's equation with the potentials
    at current collector and reaction layer as boundary conditions. Using ohmic drop
    for calculating the local current, detailed knowledge of all resistances involved
    is of prime importance. In particular, the contact resistance between the gas
    diffusion layer (GDL) and flow field rib, as well as GDL bulk conductivity, are
    strongly dependent on clamping pressure. They represent a substantial amount of
    the total ohmic drop and therefore require careful consideration. The detailed
    experimental setup as well as the concise procedure for quantitative data evaluation
    is described. Finally, the method is applied successfully to a cell operated on
    pure oxygen and air up to high current densities. The results show that electrical
    and ionic resistances seem to govern the current distribution at low current regimes,
    whereas mass transport limitations locally hamper the current production at high
    loads.
article_number: A2158
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Mathias
  full_name: Reum, Mathias
  last_name: Reum
- first_name: Jörg
  full_name: Evertz, Jörg
  last_name: Evertz
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Freunberger SA, Reum M, Evertz J, Wokaun A, Büchi FN. Measuring the current
    distribution in PEFCs with sub-millimeter resolution. <i>Journal of The Electrochemical
    Society</i>. 2006;153(11). doi:<a href="https://doi.org/10.1149/1.2345591">10.1149/1.2345591</a>
  apa: Freunberger, S. A., Reum, M., Evertz, J., Wokaun, A., &#38; Büchi, F. N. (2006).
    Measuring the current distribution in PEFCs with sub-millimeter resolution. <i>Journal
    of The Electrochemical Society</i>. The Electrochemical Society. <a href="https://doi.org/10.1149/1.2345591">https://doi.org/10.1149/1.2345591</a>
  chicago: Freunberger, Stefan Alexander, Mathias Reum, Jörg Evertz, Alexander Wokaun,
    and Felix N. Büchi. “Measuring the Current Distribution in PEFCs with Sub-Millimeter
    Resolution.” <i>Journal of The Electrochemical Society</i>. The Electrochemical
    Society, 2006. <a href="https://doi.org/10.1149/1.2345591">https://doi.org/10.1149/1.2345591</a>.
  ieee: S. A. Freunberger, M. Reum, J. Evertz, A. Wokaun, and F. N. Büchi, “Measuring
    the current distribution in PEFCs with sub-millimeter resolution,” <i>Journal
    of The Electrochemical Society</i>, vol. 153, no. 11. The Electrochemical Society,
    2006.
  ista: Freunberger SA, Reum M, Evertz J, Wokaun A, Büchi FN. 2006. Measuring the
    current distribution in PEFCs with sub-millimeter resolution. Journal of The Electrochemical
    Society. 153(11), A2158.
  mla: Freunberger, Stefan Alexander, et al. “Measuring the Current Distribution in
    PEFCs with Sub-Millimeter Resolution.” <i>Journal of The Electrochemical Society</i>,
    vol. 153, no. 11, A2158, The Electrochemical Society, 2006, doi:<a href="https://doi.org/10.1149/1.2345591">10.1149/1.2345591</a>.
  short: S.A. Freunberger, M. Reum, J. Evertz, A. Wokaun, F.N. Büchi, Journal of
    The Electrochemical Society 153 (2006).
date_created: 2020-01-15T12:23:12Z
date_published: 2006-09-20T00:00:00Z
date_updated: 2021-01-12T08:13:06Z
day: '20'
doi: 10.1149/1.2345591
extern: '1'
intvolume: '       153'
issue: '11'
language:
- iso: eng
month: '09'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
  issn:
  - 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: Measuring the current distribution in PEFCs with sub-millimeter resolution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 153
year: '2006'
...
---
_id: '7329'
abstract:
- lang: eng
  text: A novel measurement principle for measuring the current distribution in polymer
    electrolyte fuel cells (PEFCs) is introduced. It allows, in contrast to all other
    known techniques, for the first time for a resolution smaller than the channel/rib
    scale of the flow field in PEFCs. The current density is obtained by considering
    the electron conductors in the cell as a two-dimensional resistor with the voltage
    drop caused by the current. The method was applied to a cell operated on oxygen
    up to high current densities. The results show that the ohmic resistances govern
    the current distribution in the low current regime, whereas mass transport limitations
    hamper the current production under the land at high loads.
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Mathias
  full_name: Reum, Mathias
  last_name: Reum
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Freunberger SA, Reum M, Wokaun A, Büchi FN. Expanding current distribution
    measurement in PEFCs to sub-millimeter resolution. <i>Electrochemistry Communications</i>.
    2006;8(9):1435-1438. doi:<a href="https://doi.org/10.1016/j.elecom.2006.05.032">10.1016/j.elecom.2006.05.032</a>
  apa: Freunberger, S. A., Reum, M., Wokaun, A., &#38; Büchi, F. N. (2006). Expanding
    current distribution measurement in PEFCs to sub-millimeter resolution. <i>Electrochemistry
    Communications</i>. Elsevier. <a href="https://doi.org/10.1016/j.elecom.2006.05.032">https://doi.org/10.1016/j.elecom.2006.05.032</a>
  chicago: Freunberger, Stefan Alexander, Mathias Reum, Alexander Wokaun, and Felix
    N. Büchi. “Expanding Current Distribution Measurement in PEFCs to Sub-Millimeter
    Resolution.” <i>Electrochemistry Communications</i>. Elsevier, 2006. <a href="https://doi.org/10.1016/j.elecom.2006.05.032">https://doi.org/10.1016/j.elecom.2006.05.032</a>.
  ieee: S. A. Freunberger, M. Reum, A. Wokaun, and F. N. Büchi, “Expanding current
    distribution measurement in PEFCs to sub-millimeter resolution,” <i>Electrochemistry
    Communications</i>, vol. 8, no. 9. Elsevier, pp. 1435–1438, 2006.
  ista: Freunberger SA, Reum M, Wokaun A, Büchi FN. 2006. Expanding current distribution
    measurement in PEFCs to sub-millimeter resolution. Electrochemistry Communications.
    8(9), 1435–1438.
  mla: Freunberger, Stefan Alexander, et al. “Expanding Current Distribution Measurement
    in PEFCs to Sub-Millimeter Resolution.” <i>Electrochemistry Communications</i>,
    vol. 8, no. 9, Elsevier, 2006, pp. 1435–38, doi:<a href="https://doi.org/10.1016/j.elecom.2006.05.032">10.1016/j.elecom.2006.05.032</a>.
  short: S.A. Freunberger, M. Reum, A. Wokaun, F.N. Büchi, Electrochemistry Communications
    8 (2006) 1435–1438.
date_created: 2020-01-15T12:23:22Z
date_published: 2006-09-01T00:00:00Z
date_updated: 2021-01-12T08:13:06Z
day: '01'
doi: 10.1016/j.elecom.2006.05.032
extern: '1'
intvolume: '         8'
issue: '9'
language:
- iso: eng
month: '09'
oa_version: None
page: 1435-1438
publication: Electrochemistry Communications
publication_identifier:
  issn:
  - 1388-2481
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Expanding current distribution measurement in PEFCs to sub-millimeter resolution
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2006'
...
---
_id: '7330'
abstract:
- lang: eng
  text: Polymer electrolyte fuel cells (PE fuel cells) working with air at low stoichiometries
    (<2.0) and standard electrochemical components show a high degree of inhomogeneity
    in the current density distribution over the active area. An inhomogeneous current
    density distribution leads to a non-uniform utilization of the active area, which
    could negatively affect the time of life of the cells. Furthermore, it is also
    believed to lower cell performance. In this work, the homogenization of the current
    density, realized by means of tailored cathodes with along-the-air-channel redistributed
    catalyst loadings, is investigated. The air stoichiometry range for which a homogenization
    of the current density is achieved depends upon the gradient with which the catalyst
    is redistributed along the air channel. A gentle increasing catalyst loading profile
    homogenizes the current density at relatively higher air stoichiometries, while
    a steeper profile is suited better for lower air stoichiometries. The results
    show that a homogenization of the current density by means of redistributed catalyst
    loading has negative effects on cell performance. Model calculations corroborate
    the experimental findings on homogenization of the current density and deliver
    an explanation for the decrease in cell performance.
article_processing_charge: No
article_type: original
author:
- first_name: M.
  full_name: Santis, M.
  last_name: Santis
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: A.
  full_name: Reiner, A.
  last_name: Reiner
- first_name: F.N.
  full_name: Büchi, F.N.
  last_name: Büchi
citation:
  ama: Santis M, Freunberger SA, Reiner A, Büchi FN. Homogenization of the current
    density in polymer electrolyte fuel cells by in-plane cathode catalyst gradients.
    <i>Electrochimica Acta</i>. 2006;51(25):5383-5393. doi:<a href="https://doi.org/10.1016/j.electacta.2006.02.008">10.1016/j.electacta.2006.02.008</a>
  apa: Santis, M., Freunberger, S. A., Reiner, A., &#38; Büchi, F. N. (2006). Homogenization
    of the current density in polymer electrolyte fuel cells by in-plane cathode catalyst
    gradients. <i>Electrochimica Acta</i>. Elsevier. <a href="https://doi.org/10.1016/j.electacta.2006.02.008">https://doi.org/10.1016/j.electacta.2006.02.008</a>
  chicago: Santis, M., Stefan Alexander Freunberger, A. Reiner, and F.N. Büchi. “Homogenization
    of the Current Density in Polymer Electrolyte Fuel Cells by In-Plane Cathode Catalyst
    Gradients.” <i>Electrochimica Acta</i>. Elsevier, 2006. <a href="https://doi.org/10.1016/j.electacta.2006.02.008">https://doi.org/10.1016/j.electacta.2006.02.008</a>.
  ieee: M. Santis, S. A. Freunberger, A. Reiner, and F. N. Büchi, “Homogenization
    of the current density in polymer electrolyte fuel cells by in-plane cathode catalyst
    gradients,” <i>Electrochimica Acta</i>, vol. 51, no. 25. Elsevier, pp. 5383–5393,
    2006.
  ista: Santis M, Freunberger SA, Reiner A, Büchi FN. 2006. Homogenization of the
    current density in polymer electrolyte fuel cells by in-plane cathode catalyst
    gradients. Electrochimica Acta. 51(25), 5383–5393.
  mla: Santis, M., et al. “Homogenization of the Current Density in Polymer Electrolyte
    Fuel Cells by In-Plane Cathode Catalyst Gradients.” <i>Electrochimica Acta</i>,
    vol. 51, no. 25, Elsevier, 2006, pp. 5383–93, doi:<a href="https://doi.org/10.1016/j.electacta.2006.02.008">10.1016/j.electacta.2006.02.008</a>.
  short: M. Santis, S.A. Freunberger, A. Reiner, F.N. Büchi, Electrochimica Acta 51
    (2006) 5383–5393.
date_created: 2020-01-15T12:23:34Z
date_published: 2006-07-01T00:00:00Z
date_updated: 2021-01-12T08:13:07Z
day: '01'
doi: 10.1016/j.electacta.2006.02.008
extern: '1'
intvolume: '        51'
issue: '25'
language:
- iso: eng
month: '07'
oa_version: None
page: 5383-5393
publication: Electrochimica Acta
publication_identifier:
  issn:
  - 0013-4686
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Homogenization of the current density in polymer electrolyte fuel cells by
  in-plane cathode catalyst gradients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2006'
...
---
_id: '7331'
abstract:
- lang: eng
  text: A previously developed mathematical model for water management and current
    density distribution in a polymer electrolyte fuel cell (PEFCs) is employed to
    investigate the effects of cooling strategies on cell performance. The model describes
    a two-dimensional slice through the cell along the channels and through the entire
    cell sandwich including the coolant channels and the bipolar plate. Arbitrary
    flow arrangements of fuel, oxidant, and coolant stream directions can be described.
    Due to the serious impact of temperature on all processes in the PEFC, both the
    relative direction of the coolant stream to the gas streams and its mass flow
    turns out to significantly affect the cell performance. Besides influencing the
    electrochemical reaction and all kinds of mass transfer temperature, variations
    predominantly alter the local membrane hydration distribution and subseqently
    its conductivity.
article_number: A909
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: 'Freunberger SA, Wokaun A, Büchi FN. In-plane effects in large-scale PEFCs:
    II. The influence of cooling strategy on cell performance. <i>Journal of The Electrochemical
    Society</i>. 2006;153(5). doi:<a href="https://doi.org/10.1149/1.2185282">10.1149/1.2185282</a>'
  apa: 'Freunberger, S. A., Wokaun, A., &#38; Büchi, F. N. (2006). In-plane effects
    in large-scale PEFCs: II. The influence of cooling strategy on cell performance.
    <i>Journal of The Electrochemical Society</i>. The Electrochemical Society. <a
    href="https://doi.org/10.1149/1.2185282">https://doi.org/10.1149/1.2185282</a>'
  chicago: 'Freunberger, Stefan Alexander, Alexander Wokaun, and Felix N. Büchi.
    “In-Plane Effects in Large-Scale PEFCs: II. The Influence of Cooling Strategy
    on Cell Performance.” <i>Journal of The Electrochemical Society</i>. The Electrochemical
    Society, 2006. <a href="https://doi.org/10.1149/1.2185282">https://doi.org/10.1149/1.2185282</a>.'
  ieee: 'S. A. Freunberger, A. Wokaun, and F. N. Büchi, “In-plane effects in large-scale
    PEFCs: II. The influence of cooling strategy on cell performance,” <i>Journal
    of The Electrochemical Society</i>, vol. 153, no. 5. The Electrochemical Society,
    2006.'
  ista: 'Freunberger SA, Wokaun A, Büchi FN. 2006. In-plane effects in large-scale
    PEFCs: II. The influence of cooling strategy on cell performance. Journal of The
    Electrochemical Society. 153(5), A909.'
  mla: 'Freunberger, Stefan Alexander, et al. “In-Plane Effects in Large-Scale PEFCs:
    II. The Influence of Cooling Strategy on Cell Performance.” <i>Journal of The
    Electrochemical Society</i>, vol. 153, no. 5, A909, The Electrochemical Society,
    2006, doi:<a href="https://doi.org/10.1149/1.2185282">10.1149/1.2185282</a>.'
  short: S.A. Freunberger, A. Wokaun, F.N. Büchi, Journal of The Electrochemical
    Society 153 (2006).
date_created: 2020-01-15T12:23:46Z
date_published: 2006-03-27T00:00:00Z
date_updated: 2021-01-12T08:13:08Z
day: '27'
doi: 10.1149/1.2185282
extern: '1'
intvolume: '       153'
issue: '5'
language:
- iso: eng
month: '03'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
  issn:
  - 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: 'In-plane effects in large-scale PEFCs: II. The influence of cooling strategy
  on cell performance'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 153
year: '2006'
...
---
_id: '7332'
abstract:
- lang: eng
  text: A quasi-two-dimensional, along-the-channel mass and heat-transfer model for
    a proton exchange membrane fuel cell (PEFC) is described and validated against
    experimental current distribution data. The model is formulated in a dimensional
    manner, i.e., local transport phenomena are treated one-dimensional in through-plane
    direction and coupled in-plane by convective transport in the gas and coolant
    channels. Thus, a two-dimensional slice running through the repetitive unit of
    a cell from the anode channel via membrane-electrode assembly (MEA) and cathode
    channel to the coolant channel and from inlet to outlet is modeled. The aim of
    the work is to elucidate the influence of operating conditions such as feed gas
    humidities and stoichiometric ratios on the along-the-channel current density
    distribution and to identify the distinct underlying voltage loss mechanisms.
    Furthermore, a complicated technical flow field is modeled by a combination of
    co- and counterflow subdomains and compared with experimental current densities.
article_number: A396
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Marco
  full_name: Santis, Marco
  last_name: Santis
- first_name: Ingo A.
  full_name: Schneider, Ingo A.
  last_name: Schneider
- first_name: Alexander
  full_name: Wokaun, Alexander
  last_name: Wokaun
- first_name: Felix N.
  full_name: Büchi, Felix N.
  last_name: Büchi
citation:
  ama: Freunberger SA, Santis M, Schneider IA, Wokaun A, Büchi FN. In-plane effects
    in large-scale PEMFCs. <i>Journal of The Electrochemical Society</i>. 2006;153(2).
    doi:<a href="https://doi.org/10.1149/1.2150150">10.1149/1.2150150</a>
  apa: Freunberger, S. A., Santis, M., Schneider, I. A., Wokaun, A., &#38; Büchi,
    F. N. (2006). In-plane effects in large-scale PEMFCs. <i>Journal of The Electrochemical
    Society</i>. The Electrochemical Society. <a href="https://doi.org/10.1149/1.2150150">https://doi.org/10.1149/1.2150150</a>
  chicago: Freunberger, Stefan Alexander, Marco Santis, Ingo A. Schneider, Alexander
    Wokaun, and Felix N. Büchi. “In-Plane Effects in Large-Scale PEMFCs.” <i>Journal
    of The Electrochemical Society</i>. The Electrochemical Society, 2006. <a href="https://doi.org/10.1149/1.2150150">https://doi.org/10.1149/1.2150150</a>.
  ieee: S. A. Freunberger, M. Santis, I. A. Schneider, A. Wokaun, and F. N. Büchi,
    “In-plane effects in large-scale PEMFCs,” <i>Journal of The Electrochemical Society</i>,
    vol. 153, no. 2. The Electrochemical Society, 2006.
  ista: Freunberger SA, Santis M, Schneider IA, Wokaun A, Büchi FN. 2006. In-plane
    effects in large-scale PEMFCs. Journal of The Electrochemical Society. 153(2),
    A396.
  mla: Freunberger, Stefan Alexander, et al. “In-Plane Effects in Large-Scale PEMFCs.”
    <i>Journal of The Electrochemical Society</i>, vol. 153, no. 2, A396, The Electrochemical
    Society, 2006, doi:<a href="https://doi.org/10.1149/1.2150150">10.1149/1.2150150</a>.
  short: S.A. Freunberger, M. Santis, I.A. Schneider, A. Wokaun, F.N. Büchi, Journal
    of The Electrochemical Society 153 (2006).
date_created: 2020-01-15T12:24:00Z
date_published: 2006-01-04T00:00:00Z
date_updated: 2021-01-12T08:13:08Z
day: '04'
doi: 10.1149/1.2150150
extern: '1'
intvolume: '       153'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
  issn:
  - 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: In-plane effects in large-scale PEMFCs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 153
year: '2006'
...
---
_id: '1715'
abstract:
- lang: eng
  text: 'Background: Cell-to-cell communication at the synapse involves synaptic transmission
    as well as signaling mediated by growth factors, which provide developmental and
    plasticity cues. There is evidence that a retrograde, presynaptic transforming
    growth factor-β (TGF-β) signaling event regulates synapse development and function
    in Drosophila. Results: Here we show that a postsynaptic TGF-β signaling event
    occurs during larval development. The type I receptor Thick veins (Tkv) and the
    R-Smad transcription factor Mothers-against-dpp (Mad) are localized postsynaptically
    in the muscle. Furthermore, Mad phosphorylation occurs in regions facing the presynaptic
    active zones of neurotransmitter release within the postsynaptic subsynaptic reticulum
    (SSR). In order to monitor in real time the levels of TGF-β signaling in the synapse
    during synaptic transmission, we have established a FRAP assay to measure Mad
    nuclear import/export in the muscle. We show that Mad nuclear trafficking depends
    on stimulation of the muscle. Conclusions: Our data suggest a mechanism linking
    synaptic transmission and postsynaptic TGF-β signaling that may coordinate nerve-muscle
    development and function.'
acknowledgement: This work was supported by the Max Planck Society, HFSP, and Deutsche
  Forschungsgemeinschaft.
article_processing_charge: No
author:
- first_name: Veronika
  full_name: Dudu, Veronika
  last_name: Dudu
- first_name: Thomas
  full_name: Bittig, Thomas
  last_name: Bittig
- first_name: Eugeni
  full_name: Entchev, Eugeni
  last_name: Entchev
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Frank
  full_name: Julicher, Frank
  last_name: Julicher
- first_name: Marcos
  full_name: González Gaitán, Marcos
  last_name: González Gaitán
citation:
  ama: Dudu V, Bittig T, Entchev E, Kicheva A, Julicher F, González Gaitán M. Postsynaptic
    mad signaling at the Drosophila neuromuscular junction. <i>Current Biology</i>.
    2006;16(7):625-635. doi:<a href="https://doi.org/10.1016/j.cub.2006.02.061">10.1016/j.cub.2006.02.061</a>
  apa: Dudu, V., Bittig, T., Entchev, E., Kicheva, A., Julicher, F., &#38; González
    Gaitán, M. (2006). Postsynaptic mad signaling at the Drosophila neuromuscular
    junction. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2006.02.061">https://doi.org/10.1016/j.cub.2006.02.061</a>
  chicago: Dudu, Veronika, Thomas Bittig, Eugeni Entchev, Anna Kicheva, Frank Julicher,
    and Marcos González Gaitán. “Postsynaptic Mad Signaling at the Drosophila Neuromuscular
    Junction.” <i>Current Biology</i>. Cell Press, 2006. <a href="https://doi.org/10.1016/j.cub.2006.02.061">https://doi.org/10.1016/j.cub.2006.02.061</a>.
  ieee: V. Dudu, T. Bittig, E. Entchev, A. Kicheva, F. Julicher, and M. González Gaitán,
    “Postsynaptic mad signaling at the Drosophila neuromuscular junction,” <i>Current
    Biology</i>, vol. 16, no. 7. Cell Press, pp. 625–635, 2006.
  ista: Dudu V, Bittig T, Entchev E, Kicheva A, Julicher F, González Gaitán M. 2006.
    Postsynaptic mad signaling at the Drosophila neuromuscular junction. Current Biology.
    16(7), 625–635.
  mla: Dudu, Veronika, et al. “Postsynaptic Mad Signaling at the Drosophila Neuromuscular
    Junction.” <i>Current Biology</i>, vol. 16, no. 7, Cell Press, 2006, pp. 625–35,
    doi:<a href="https://doi.org/10.1016/j.cub.2006.02.061">10.1016/j.cub.2006.02.061</a>.
  short: V. Dudu, T. Bittig, E. Entchev, A. Kicheva, F. Julicher, M. González Gaitán,
    Current Biology 16 (2006) 625–635.
date_created: 2018-12-11T11:53:37Z
date_published: 2006-04-04T00:00:00Z
date_updated: 2021-11-16T07:44:15Z
day: '04'
doi: 10.1016/j.cub.2006.02.061
extern: '1'
intvolume: '        16'
issue: '7'
language:
- iso: eng
month: '04'
oa_version: None
page: 625 - 635
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '5416'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1016/j.cub.2006.06.020
status: public
title: Postsynaptic mad signaling at the Drosophila neuromuscular junction
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 16
year: '2006'
...
---
_id: '1745'
abstract:
- lang: eng
  text: SiGe islands grown by deposition of 10 monolayers of Ge on Si(0 0 1) at 740
    °C were investigated by using a combination of selective wet chemical etching
    and atomic force microscopy. The used etchant, a solution consisting of ammonium
    hydroxide and hydrogen peroxide, shows a high selectivity of Ge over SixGe1-x
    and is characterized by relatively slow etching rates for Si-rich alloys. By performing
    successive etching experiments on the same sample area, we are able to gain a
    deeper insight into the lateral displacement the islands undergo during post growth
    annealing.
author:
- first_name: Georgios
  full_name: Georgios Katsaros
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
- first_name: Armando
  full_name: Rastelli, Armando
  last_name: Rastelli
- first_name: Mathieu
  full_name: Stoffel, Mathieu
  last_name: Stoffel
- first_name: Giovanni
  full_name: Isella, Giovanni
  last_name: Isella
- first_name: Hans
  full_name: Von Känel, Hans
  last_name: Von Känel
- first_name: Alexander
  full_name: Bittner, Alexander M
  last_name: Bittner
- first_name: Jerry
  full_name: Tersoff, Jerry
  last_name: Tersoff
- first_name: Ulrich
  full_name: Denker, Ulrich
  last_name: Denker
- first_name: Oliver
  full_name: Schmidt, Oliver G
  last_name: Schmidt
- first_name: Giovanni
  full_name: Costantini, Giovanni
  last_name: Costantini
- first_name: Klaus
  full_name: Kern, Klaus
  last_name: Kern
citation:
  ama: Katsaros G, Rastelli A, Stoffel M, et al. Investigating the lateral motion
    of SiGe islands by selective chemical etching. <i>Surface Science</i>. 2006;600(12):2608-2613.
    doi:<a href="https://doi.org/10.1016/j.susc.2006.04.027">10.1016/j.susc.2006.04.027</a>
  apa: Katsaros, G., Rastelli, A., Stoffel, M., Isella, G., Von Känel, H., Bittner,
    A., … Kern, K. (2006). Investigating the lateral motion of SiGe islands by selective
    chemical etching. <i>Surface Science</i>. Elsevier. <a href="https://doi.org/10.1016/j.susc.2006.04.027">https://doi.org/10.1016/j.susc.2006.04.027</a>
  chicago: Katsaros, Georgios, Armando Rastelli, Mathieu Stoffel, Giovanni Isella,
    Hans Von Känel, Alexander Bittner, Jerry Tersoff, et al. “Investigating the Lateral
    Motion of SiGe Islands by Selective Chemical Etching.” <i>Surface Science</i>.
    Elsevier, 2006. <a href="https://doi.org/10.1016/j.susc.2006.04.027">https://doi.org/10.1016/j.susc.2006.04.027</a>.
  ieee: G. Katsaros <i>et al.</i>, “Investigating the lateral motion of SiGe islands
    by selective chemical etching,” <i>Surface Science</i>, vol. 600, no. 12. Elsevier,
    pp. 2608–2613, 2006.
  ista: Katsaros G, Rastelli A, Stoffel M, Isella G, Von Känel H, Bittner A, Tersoff
    J, Denker U, Schmidt O, Costantini G, Kern K. 2006. Investigating the lateral
    motion of SiGe islands by selective chemical etching. Surface Science. 600(12),
    2608–2613.
  mla: Katsaros, Georgios, et al. “Investigating the Lateral Motion of SiGe Islands
    by Selective Chemical Etching.” <i>Surface Science</i>, vol. 600, no. 12, Elsevier,
    2006, pp. 2608–13, doi:<a href="https://doi.org/10.1016/j.susc.2006.04.027">10.1016/j.susc.2006.04.027</a>.
  short: G. Katsaros, A. Rastelli, M. Stoffel, G. Isella, H. Von Känel, A. Bittner,
    J. Tersoff, U. Denker, O. Schmidt, G. Costantini, K. Kern, Surface Science 600
    (2006) 2608–2613.
date_created: 2018-12-11T11:53:47Z
date_published: 2006-06-15T00:00:00Z
date_updated: 2021-01-12T06:52:56Z
day: '15'
doi: 10.1016/j.susc.2006.04.027
extern: 1
intvolume: '       600'
issue: '12'
month: '06'
page: 2608 - 2613
publication: Surface Science
publication_status: published
publisher: Elsevier
publist_id: '5379'
quality_controlled: 0
status: public
title: Investigating the lateral motion of SiGe islands by selective chemical etching
type: journal_article
volume: 600
year: '2006'
...
