---
_id: '12201'
abstract:
- lang: eng
  text: The development of plant lateral organs is interesting because, although many
    of the same genes seem to be involved in the early growth of primordia, completely
    different gene combinations are required for the complete development of organs
    such as leaves and stamens. Thus, the genes common to the development of most
    organs, which generally form and polarize the primordial ‘envelope’, must at some
    stage interact with those that ‘install’ the functional content of the organ –
    in the case of the stamen, the four microsporangia. Although distinct genetic
    pathways of organ initiation, polarity establishment and setting up the reproductive
    cell line can readily be recognized, they do not occur sequentially. Rather, they
    are activated early and run in parallel. There is evidence for continuing crosstalk
    between these pathways.
acknowledgement: X.F. holds a Clarendon Scholarship from the University of Oxford.
  We thank Angela Hay and Jill Harrison for helpful advice and discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Hugh G.
  full_name: Dickinson, Hugh G.
  last_name: Dickinson
citation:
  ama: Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>.
    2007;23(10):503-510. doi:<a href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>
  apa: Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants.
    <i>Trends in Genetics</i>. Elsevier BV. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>
  chicago: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>.
  ieee: X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends
    in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.
  ista: Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends
    in Genetics. 23(10), 503–510.
  mla: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a
    href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>.
  short: X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510.
date_created: 2023-01-16T09:22:44Z
date_published: 2007-10-01T00:00:00Z
date_updated: 2023-05-08T10:58:47Z
department:
- _id: XiFe
doi: 10.1016/j.tig.2007.08.005
extern: '1'
external_id:
  pmid:
  - '17825943'
intvolume: '        23'
issue: '10'
keyword:
- Genetics
language:
- iso: eng
month: '10'
oa_version: None
page: 503-510
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Packaging the male germline in plants
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2007'
...
---
_id: '128'
abstract:
- lang: eng
  text: 'A 671 nm diode laser with a mode-hop-free tuning range of 40 GHz is described.
    This long tuning range is achieved by simultaneously ramping the external cavity
    length with the laser injection current. The laser output pointing remains fixed,
    independent of its frequency because of the cover slip cavity design. This system
    is simple, economical, robust, and easy to use for spectroscopy, as we demonstrate
    with lithium vapor and lithium atom beam experiments. '
acknowledgement: "National Science Foundation\r\nThis work was supported with NSF
  Grant No. PHY-0653623. We thank Dr. W. Bickel and Dr. J. Jones for diagnostic equipment,
  K. Guerin for assistance with mechanical drawings, and M. Parker of Rincon Research
  Inc. for optics components."
article_number: '106108'
arxiv: 1
author:
- first_name: Adra
  full_name: Carr, Adra
  last_name: Carr
- first_name: Yancey
  full_name: Serchest, Yancey
  last_name: Serchest
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
- first_name: John
  full_name: Perreault, John
  last_name: Perreault
- first_name: Vincent
  full_name: Lonij, Vincent
  last_name: Lonij
- first_name: Alexander
  full_name: Cronin, Alexander
  last_name: Cronin
citation:
  ama: Carr A, Serchest Y, Waitukaitis SR, Perreault J, Lonij V, Cronin A. Cover slip
    external cavity diode laser. <i>Review of Scientific Instruments</i>. 2007;78(10).
    doi:<a href="https://doi.org/10.1063/1.2801006">10.1063/1.2801006</a>
  apa: Carr, A., Serchest, Y., Waitukaitis, S. R., Perreault, J., Lonij, V., &#38;
    Cronin, A. (2007). Cover slip external cavity diode laser. <i>Review of Scientific
    Instruments</i>. American Institute of Physics. <a href="https://doi.org/10.1063/1.2801006">https://doi.org/10.1063/1.2801006</a>
  chicago: Carr, Adra, Yancey Serchest, Scott R Waitukaitis, John Perreault, Vincent
    Lonij, and Alexander Cronin. “Cover Slip External Cavity Diode Laser.” <i>Review
    of Scientific Instruments</i>. American Institute of Physics, 2007. <a href="https://doi.org/10.1063/1.2801006">https://doi.org/10.1063/1.2801006</a>.
  ieee: A. Carr, Y. Serchest, S. R. Waitukaitis, J. Perreault, V. Lonij, and A. Cronin,
    “Cover slip external cavity diode laser,” <i>Review of Scientific Instruments</i>,
    vol. 78, no. 10. American Institute of Physics, 2007.
  ista: Carr A, Serchest Y, Waitukaitis SR, Perreault J, Lonij V, Cronin A. 2007.
    Cover slip external cavity diode laser. Review of Scientific Instruments. 78(10),
    106108.
  mla: Carr, Adra, et al. “Cover Slip External Cavity Diode Laser.” <i>Review of Scientific
    Instruments</i>, vol. 78, no. 10, 106108, American Institute of Physics, 2007,
    doi:<a href="https://doi.org/10.1063/1.2801006">10.1063/1.2801006</a>.
  short: A. Carr, Y. Serchest, S.R. Waitukaitis, J. Perreault, V. Lonij, A. Cronin,
    Review of Scientific Instruments 78 (2007).
date_created: 2018-12-11T11:44:46Z
date_published: 2007-10-29T00:00:00Z
date_updated: 2021-01-12T06:49:35Z
day: '29'
doi: 10.1063/1.2801006
extern: '1'
external_id:
  arxiv:
  - '0708.0014'
intvolume: '        78'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/0708.0014
month: '10'
oa: 1
oa_version: Preprint
publication: Review of Scientific Instruments
publication_status: published
publisher: American Institute of Physics
publist_id: '7925'
quality_controlled: '1'
status: public
title: Cover slip external cavity diode laser
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 78
year: '2007'
...
---
_id: '1297'
abstract:
- lang: eng
  text: In flies, the large tangential cells of the lobula plate represent an important
    processing center for visual navigation based on optic flow. Although the visual
    response properties of these cells have been well studied in blowflies, information
    on their synaptic organization is mostly lacking. Here we study the distribution
    of presynaptic release and postsynaptic inhibitory sites in the same set of cells
    in Drosophila melanogaster. By making use of transgenic tools and immunohistochemistry,
    our results suggest that HS and VS cells of Drosophila express γ-aminobutyric
    acid (GABA) receptors in their dendritic region within the lobula plate, thus
    being postsynaptic to inhibitory input there. At their axon terminals in the protocerebrum,
    both cell types express synaptobrevin, suggesting the presence of presynaptic
    specializations there. HS- and VS-cell terminals additionally show evidence for
    postsynaptic GABAergic input, superimposed on this synaptic polarity. Our findings
    are in line with the general circuit for visual motion detection and receptive
    field properties as postulated from electrophysiological and optical recordings
    in blowflies, suggesting a similar functional organization of lobula plate tangential
    cells in the two species.
author:
- first_name: Shamprasad
  full_name: Raghu, Shamprasad V
  last_name: Raghu
- first_name: Maximilian A
  full_name: Maximilian Jösch
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
- first_name: Alexander
  full_name: Borst, Alexander
  last_name: Borst
- first_name: Dierk
  full_name: Reiff, Dierk F
  last_name: Reiff
citation:
  ama: 'Raghu S, Jösch MA, Borst A, Reiff D. Synaptic organization of lobula plate
    tangential cells in Drosophila: γ-aminobutyric acid receptors and chemical release
    sites. <i>Journal of Comparative Neurology</i>. 2007;502(4):598-610. doi:<a href="https://doi.org/10.1002/cne.21319">10.1002/cne.21319</a>'
  apa: 'Raghu, S., Jösch, M. A., Borst, A., &#38; Reiff, D. (2007). Synaptic organization
    of lobula plate tangential cells in Drosophila: γ-aminobutyric acid receptors
    and chemical release sites. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1002/cne.21319">https://doi.org/10.1002/cne.21319</a>'
  chicago: 'Raghu, Shamprasad, Maximilian A Jösch, Alexander Borst, and Dierk Reiff.
    “Synaptic Organization of Lobula Plate Tangential Cells in Drosophila: γ-Aminobutyric
    Acid Receptors and Chemical Release Sites.” <i>Journal of Comparative Neurology</i>.
    Wiley-Blackwell, 2007. <a href="https://doi.org/10.1002/cne.21319">https://doi.org/10.1002/cne.21319</a>.'
  ieee: 'S. Raghu, M. A. Jösch, A. Borst, and D. Reiff, “Synaptic organization of
    lobula plate tangential cells in Drosophila: γ-aminobutyric acid receptors and
    chemical release sites,” <i>Journal of Comparative Neurology</i>, vol. 502, no.
    4. Wiley-Blackwell, pp. 598–610, 2007.'
  ista: 'Raghu S, Jösch MA, Borst A, Reiff D. 2007. Synaptic organization of lobula
    plate tangential cells in Drosophila: γ-aminobutyric acid receptors and chemical
    release sites. Journal of Comparative Neurology. 502(4), 598–610.'
  mla: 'Raghu, Shamprasad, et al. “Synaptic Organization of Lobula Plate Tangential
    Cells in Drosophila: γ-Aminobutyric Acid Receptors and Chemical Release Sites.”
    <i>Journal of Comparative Neurology</i>, vol. 502, no. 4, Wiley-Blackwell, 2007,
    pp. 598–610, doi:<a href="https://doi.org/10.1002/cne.21319">10.1002/cne.21319</a>.'
  short: S. Raghu, M.A. Jösch, A. Borst, D. Reiff, Journal of Comparative Neurology
    502 (2007) 598–610.
date_created: 2018-12-11T11:51:13Z
date_published: 2007-06-01T00:00:00Z
date_updated: 2021-01-12T06:49:42Z
day: '01'
doi: 10.1002/cne.21319
extern: 1
intvolume: '       502'
issue: '4'
month: '06'
page: 598 - 610
publication: Journal of Comparative Neurology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5974'
quality_controlled: 0
status: public
title: 'Synaptic organization of lobula plate tangential cells in Drosophila: γ-aminobutyric
  acid receptors and chemical release sites'
type: journal_article
volume: 502
year: '2007'
...
---
_id: '3411'
abstract:
- lang: eng
  text: Mechanical single-molecule techniques offer exciting possibilities to investigate
    protein folding and stability in native environments at submolecular resolution.
    By applying a free-energy reconstruction procedure developed by Hummer and Szabo,
    which is based on a statistical theorem introduced by Jarzynski, we determined
    the unfolding free energy of the membrane proteins bacteriorhodopsin (BR), halorhodopsin,
    and the sodium-proton antiporter NhaA. The calculated energies ranged from 290.5kcal/mol
    for BR to 485.5kcal/mol for NhaA. For the remarkably stable BR, the equilibrium
    unfolding free energy was independent of pulling rate and temperature ranging
    between 18 and 42°C. Our experiments also revealed heterogeneous energetic properties
    in individual transmembrane helices. In halorhodopsin, the stabilization of a
    short helical segment yielded a characteristic signature in the energy profile.
    In NhaA, a pronounced peak was observed at a functionally important site in the
    protein. Since a large variety of single- and multispan membrane proteins can
    be tackled in mechanical unfolding experiments, our approach provides a basis
    for systematically elucidating energetic properties of membrane proteins with
    the resolution of individual secondary-structure elements.
author:
- first_name: Johannes
  full_name: Preiner, Johannes
  last_name: Preiner
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Christian
  full_name: Rankl, Christian
  last_name: Rankl
- first_name: Helene
  full_name: Knaus, Helene
  last_name: Knaus
- first_name: David
  full_name: Cisneros, David A
  last_name: Cisneros
- first_name: Alexej
  full_name: Kedrov, Alexej
  last_name: Kedrov
- first_name: Ferry
  full_name: Kienberger, Ferry
  last_name: Kienberger
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
- first_name: Peter
  full_name: Hinterdorfer, Peter
  last_name: Hinterdorfer
citation:
  ama: Preiner J, Janovjak HL, Rankl C, et al. Free energy of membrane protein unfolding
    derived from single-molecule force measurements. <i>Biophysical Journal</i>. 2007;93(3):930-937.
    doi:<a href="https://doi.org/10.1529/biophysj.106.096982">10.1529/biophysj.106.096982</a>
  apa: Preiner, J., Janovjak, H. L., Rankl, C., Knaus, H., Cisneros, D., Kedrov, A.,
    … Hinterdorfer, P. (2007). Free energy of membrane protein unfolding derived from
    single-molecule force measurements. <i>Biophysical Journal</i>. Biophysical Society.
    <a href="https://doi.org/10.1529/biophysj.106.096982">https://doi.org/10.1529/biophysj.106.096982</a>
  chicago: Preiner, Johannes, Harald L Janovjak, Christian Rankl, Helene Knaus, David
    Cisneros, Alexej Kedrov, Ferry Kienberger, Daniel Mueller, and Peter Hinterdorfer.
    “Free Energy of Membrane Protein Unfolding Derived from Single-Molecule Force
    Measurements.” <i>Biophysical Journal</i>. Biophysical Society, 2007. <a href="https://doi.org/10.1529/biophysj.106.096982">https://doi.org/10.1529/biophysj.106.096982</a>.
  ieee: J. Preiner <i>et al.</i>, “Free energy of membrane protein unfolding derived
    from single-molecule force measurements,” <i>Biophysical Journal</i>, vol. 93,
    no. 3. Biophysical Society, pp. 930–937, 2007.
  ista: Preiner J, Janovjak HL, Rankl C, Knaus H, Cisneros D, Kedrov A, Kienberger
    F, Mueller D, Hinterdorfer P. 2007. Free energy of membrane protein unfolding
    derived from single-molecule force measurements. Biophysical Journal. 93(3), 930–937.
  mla: Preiner, Johannes, et al. “Free Energy of Membrane Protein Unfolding Derived
    from Single-Molecule Force Measurements.” <i>Biophysical Journal</i>, vol. 93,
    no. 3, Biophysical Society, 2007, pp. 930–37, doi:<a href="https://doi.org/10.1529/biophysj.106.096982">10.1529/biophysj.106.096982</a>.
  short: J. Preiner, H.L. Janovjak, C. Rankl, H. Knaus, D. Cisneros, A. Kedrov, F.
    Kienberger, D. Mueller, P. Hinterdorfer, Biophysical Journal 93 (2007) 930–937.
date_created: 2018-12-11T12:03:11Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2021-01-12T07:43:18Z
day: '01'
doi: 10.1529/biophysj.106.096982
extern: 1
intvolume: '        93'
issue: '3'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1913163/
month: '08'
oa: 1
page: 930 - 937
publication: Biophysical Journal
publication_status: published
publisher: Biophysical Society
publist_id: '2990'
quality_controlled: 0
status: public
title: Free energy of membrane protein unfolding derived from single-molecule force
  measurements
type: journal_article
volume: 93
year: '2007'
...
---
_id: '3412'
abstract:
- lang: eng
  text: |-
    Molecular interactions are the basic language of biological processes.
    They establish the forces interacting between the building blocks of
    proteins and other macromolecules, thus determining their functional
    roles. Because molecular interactions trigger virtually every
    biological process, approaches to decipher their language are needed.
    Single-molecule force spectroscopy (SMFS) has been used to detect
    and characterize different types of molecular interactions that occur
    between and within native membrane proteins. The first experiments
    detected and localized molecular interactions that stabilized
    membrane proteins, including how these interactions were established
    during folding of α-helical secondary structure elements into
    the native protein and how they changed with oligomerization, temperature,
    and mutations. SMFS also enables investigators to detect
    and locate molecular interactions established during ligand and inhibitor
    binding. These exciting applications provide opportunities
    for studying the molecular forces of life. Further developments will
    elucidate the origins of molecular interactions encoded in their lifetimes,
    interaction ranges, interplay, and dynamics characteristic of biological systems.
author:
- first_name: Alexej
  full_name: Kedrov, Alexej
  last_name: Kedrov
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Tanuj
  full_name: Sapra, Tanuj K
  last_name: Sapra
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
citation:
  ama: Kedrov A, Janovjak HL, Sapra T, Mueller D. Deciphering molecular interactions
    of native membrane proteins by single-molecule force spectroscopy. <i>Annual Review
    of Biophysics</i>. 2007;36:233-260. doi:<a href="https://doi.org/10.1146/annurev.biophys.36.040306.132640">10.1146/annurev.biophys.36.040306.132640</a>
  apa: Kedrov, A., Janovjak, H. L., Sapra, T., &#38; Mueller, D. (2007). Deciphering
    molecular interactions of native membrane proteins by single-molecule force spectroscopy.
    <i>Annual Review of Biophysics</i>. Annual Reviews. <a href="https://doi.org/10.1146/annurev.biophys.36.040306.132640">https://doi.org/10.1146/annurev.biophys.36.040306.132640</a>
  chicago: Kedrov, Alexej, Harald L Janovjak, Tanuj Sapra, and Daniel Mueller. “Deciphering
    Molecular Interactions of Native Membrane Proteins by Single-Molecule Force Spectroscopy.”
    <i>Annual Review of Biophysics</i>. Annual Reviews, 2007. <a href="https://doi.org/10.1146/annurev.biophys.36.040306.132640">https://doi.org/10.1146/annurev.biophys.36.040306.132640</a>.
  ieee: A. Kedrov, H. L. Janovjak, T. Sapra, and D. Mueller, “Deciphering molecular
    interactions of native membrane proteins by single-molecule force spectroscopy,”
    <i>Annual Review of Biophysics</i>, vol. 36. Annual Reviews, pp. 233–260, 2007.
  ista: Kedrov A, Janovjak HL, Sapra T, Mueller D. 2007. Deciphering molecular interactions
    of native membrane proteins by single-molecule force spectroscopy. Annual Review
    of Biophysics. 36, 233–260.
  mla: Kedrov, Alexej, et al. “Deciphering Molecular Interactions of Native Membrane
    Proteins by Single-Molecule Force Spectroscopy.” <i>Annual Review of Biophysics</i>,
    vol. 36, Annual Reviews, 2007, pp. 233–60, doi:<a href="https://doi.org/10.1146/annurev.biophys.36.040306.132640">10.1146/annurev.biophys.36.040306.132640</a>.
  short: A. Kedrov, H.L. Janovjak, T. Sapra, D. Mueller, Annual Review of Biophysics
    36 (2007) 233–260.
date_created: 2018-12-11T12:03:11Z
date_published: 2007-06-01T00:00:00Z
date_updated: 2019-04-26T07:22:27Z
day: '01'
doi: 10.1146/annurev.biophys.36.040306.132640
extern: 1
intvolume: '        36'
month: '06'
page: 233 - 260
publication: Annual Review of Biophysics
publication_status: published
publisher: Annual Reviews
publist_id: '2989'
quality_controlled: 0
status: public
title: Deciphering molecular interactions of native membrane proteins by single-molecule
  force spectroscopy
type: review
volume: 36
year: '2007'
...
---
_id: '3427'
abstract:
- lang: eng
  text: "We present a general theoretical framework to discuss mechanisms of morphogen
    transport and gradient formation in a cell layer. Trafficking events on the cellular
    scale lead to transport on larger scales. We discuss in particular the case of
    transcytosis where morphogens undergo repeated rounds of internalization into
    cells and recycling. Based on a description on the cellular scale, we derive effective
    nonlinear transport equations in one and two dimensions which are valid on larger
    scales. We derive analytic expressions for the concentration dependence of the
    effective diffusion coefficient and the effective degradation rate. We discuss
    the effects of a directional bias on morphogen transport and those of the coupling
    of the morphogen and receptor kinetics. Furthermore, we discuss general properties
    of cellular transport processes such as the robustness of gradients and relate
    our results to recent experiments on the morphogen Decapentaplegic (Dpp) that
    acts in the wing disk of the fruit fly Drosophila.\r\n© 2007 The American Physical
    Society"
article_processing_charge: No
arxiv: 1
author:
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Karsten
  full_name: Kruse, Karsten
  last_name: Kruse
- first_name: Periklis
  full_name: Pantazis, Periklis
  last_name: Pantazis
- first_name: Marcos
  full_name: Gonzalez Gaitan, Marcos
  last_name: Gonzalez Gaitan
- first_name: Frank
  full_name: Julicher, Frank
  last_name: Julicher
citation:
  ama: Bollenbach MT, Kruse K, Pantazis P, Gonzalez Gaitan M, Julicher F. Morphogen
    transport in epithelia. <i>Physical Review E Statistical Nonlinear and Soft Matter
    Physics</i>. 2007;75(1). doi:<a href="https://doi.org/10.1103/PhysRevE.75.011901">10.1103/PhysRevE.75.011901</a>
  apa: Bollenbach, M. T., Kruse, K., Pantazis, P., Gonzalez Gaitan, M., &#38; Julicher,
    F. (2007). Morphogen transport in epithelia. <i>Physical Review E Statistical
    Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href="https://doi.org/10.1103/PhysRevE.75.011901">https://doi.org/10.1103/PhysRevE.75.011901</a>
  chicago: Bollenbach, Mark Tobias, Karsten Kruse, Periklis Pantazis, Marcos Gonzalez
    Gaitan, and Frank Julicher. “Morphogen Transport in Epithelia.” <i>Physical Review
    E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics,
    2007. <a href="https://doi.org/10.1103/PhysRevE.75.011901">https://doi.org/10.1103/PhysRevE.75.011901</a>.
  ieee: M. T. Bollenbach, K. Kruse, P. Pantazis, M. Gonzalez Gaitan, and F. Julicher,
    “Morphogen transport in epithelia,” <i>Physical Review E Statistical Nonlinear
    and Soft Matter Physics</i>, vol. 75, no. 1. American Institute of Physics, 2007.
  ista: Bollenbach MT, Kruse K, Pantazis P, Gonzalez Gaitan M, Julicher F. 2007. Morphogen
    transport in epithelia. Physical Review E Statistical Nonlinear and Soft Matter
    Physics. 75(1).
  mla: Bollenbach, Mark Tobias, et al. “Morphogen Transport in Epithelia.” <i>Physical
    Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 75, no. 1, American
    Institute of Physics, 2007, doi:<a href="https://doi.org/10.1103/PhysRevE.75.011901">10.1103/PhysRevE.75.011901</a>.
  short: M.T. Bollenbach, K. Kruse, P. Pantazis, M. Gonzalez Gaitan, F. Julicher,
    Physical Review E Statistical Nonlinear and Soft Matter Physics 75 (2007).
date_created: 2018-12-11T12:03:16Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:43:24Z
day: '01'
doi: 10.1103/PhysRevE.75.011901
extern: '1'
external_id:
  arxiv:
  - q-bio/0609011v1
intvolume: '        75'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/q-bio/0609011v1
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review E Statistical Nonlinear and Soft Matter Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '2974'
status: public
title: Morphogen transport in epithelia
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 75
year: '2007'
...
---
_id: '3432'
abstract:
- lang: eng
  text: Evolution has left its signature on the molecules and morphology of living
    organisms. Ancestral reconstruction offers an excellent tool for understanding
    the process of evolution using comparative information. Methods for ancestral
    reconstruction have generally focused on reconstructing the ancestral states at
    the internal nodes of a phylogeny. Often, we are not interested in particular
    nodes of the phylogeny but the whole history of a character. This chapter focuses
    on a Bayesian method for estimating these histories, or mutational paths, on phylogenies.
    Mutational path methods differ most notably from other approaches in their ability
    to estimate not only the ancestral states at the internal nodes of a phylogeny,
    but also the order and timing of mutational changes across the phylogeny. The
    chapter provides a concise introduction to the statistical tools needed for sampling
    mutational paths on a phylogeny.
author:
- first_name: Jonathan P
  full_name: Jonathan Bollback
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
- first_name: Paul
  full_name: Gardner, Paul P
  last_name: Gardner
- first_name: Rasmus
  full_name: Nielsen, Rasmus
  last_name: Nielsen
citation:
  ama: 'Bollback JP, Gardner P, Nielsen R. Estimating the history of mutations on
    a phylogeny. In: Liberles D, ed. <i>Ancestral Sequence Reconstruction</i>. Oxford
    University Press; 2007:69-79. doi:<a href="https://doi.org/10.1093/acprof:oso/9780199299188.003.0006">10.1093/acprof:oso/9780199299188.003.0006</a>'
  apa: Bollback, J. P., Gardner, P., &#38; Nielsen, R. (2007). Estimating the history
    of mutations on a phylogeny. In D. Liberles (Ed.), <i>Ancestral Sequence Reconstruction</i>
    (pp. 69–79). Oxford University Press. <a href="https://doi.org/10.1093/acprof:oso/9780199299188.003.0006">https://doi.org/10.1093/acprof:oso/9780199299188.003.0006</a>
  chicago: Bollback, Jonathan P, Paul Gardner, and Rasmus Nielsen. “Estimating the
    History of Mutations on a Phylogeny.” In <i>Ancestral Sequence Reconstruction</i>,
    edited by David Liberles, 69–79. Oxford University Press, 2007. <a href="https://doi.org/10.1093/acprof:oso/9780199299188.003.0006">https://doi.org/10.1093/acprof:oso/9780199299188.003.0006</a>.
  ieee: J. P. Bollback, P. Gardner, and R. Nielsen, “Estimating the history of mutations
    on a phylogeny,” in <i>Ancestral Sequence Reconstruction</i>, D. Liberles, Ed.
    Oxford University Press, 2007, pp. 69–79.
  ista: 'Bollback JP, Gardner P, Nielsen R. 2007.Estimating the history of mutations
    on a phylogeny. In: Ancestral Sequence Reconstruction. , 69–79.'
  mla: Bollback, Jonathan P., et al. “Estimating the History of Mutations on a Phylogeny.”
    <i>Ancestral Sequence Reconstruction</i>, edited by David Liberles, Oxford University
    Press, 2007, pp. 69–79, doi:<a href="https://doi.org/10.1093/acprof:oso/9780199299188.003.0006">10.1093/acprof:oso/9780199299188.003.0006</a>.
  short: J.P. Bollback, P. Gardner, R. Nielsen, in:, D. Liberles (Ed.), Ancestral
    Sequence Reconstruction, Oxford University Press, 2007, pp. 69–79.
date_created: 2018-12-11T12:03:18Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:43:26Z
day: '01'
doi: 10.1093/acprof:oso/9780199299188.003.0006
editor:
- first_name: David
  full_name: Liberles, David A
  last_name: Liberles
extern: 1
month: '01'
page: 69 - 79
publication: Ancestral Sequence Reconstruction
publication_status: published
publisher: Oxford University Press
publist_id: '2968'
quality_controlled: 0
status: public
title: Estimating the history of mutations on a phylogeny
type: book_chapter
year: '2007'
...
---
_id: '3436'
abstract:
- lang: eng
  text: 'he potential for di? erences between genetic paternity and paternity inferred
    from behavioral observation has long been recognized. These di? erences are associated
    with the challenge for females of seeking both genetic and material bene? ts;
    this challenge is less severe in species with polygynous, non-resource-based mating
    systems (such as leks) than in those with resource-based systems. We pres- ent
    the ? rst study of paternity patt erns in a non-resource-based species that does
    not form true leks. We compared paternity inferred from observed mating behavior
    to genetically assigned paternity in the Satin Bowerbird (Ptilonorhynchus violaceus)
    using eight microsatellite markers. Mating behavior was observed and recorded
    via automated video-cameras positioned at all bowers (29?34 bowers each year)
    in the study site throughout each mating season. We obtained blood samples and
    identi- ? ed mothers for 11 chicks in 9 nests. For all chicks, the most likely
    genetic father had been observed to mate with the mother in the year the chick
    was sampled. All most likely genetic fathers were assigned with high con? dence
    and all were bower- holding males. These results demonstrate that genetic paternity
    can be inferred from observed mating behavior with reasonable con? dence in Satin
    Bowerbirds. Observed male mating-success is therefore a reliable predictor of
    reproductive success, and this suggests that high skew in observed male mating-success
    translates directly to high skew in reproductive success. '
author:
- first_name: Sheila
  full_name: Reynolds, Sheila M
  last_name: Reynolds
- first_name: Katie
  full_name: Dryer, Katie
  last_name: Dryer
- first_name: Jonathan P
  full_name: Jonathan Bollback
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
- first_name: J Albert
  full_name: Uy, J Albert
  last_name: Uy
- first_name: Gail
  full_name: Patricelli, Gail L
  last_name: Patricelli
- first_name: Timothy
  full_name: Robson, Timothy
  last_name: Robson
- first_name: Gerald
  full_name: Borgia, Gerald
  last_name: Borgia
- first_name: Michael
  full_name: Braun, Michael J
  last_name: Braun
citation:
  ama: Reynolds S, Dryer K, Bollback JP, et al. Behavioral paternity predicts genetic
    paternity in satin bowerbirds, a species with a non-resource-based mating system.
    <i>The Auk</i>. 2007;124(3):857-867. doi:<a href="https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2">10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2</a>
  apa: Reynolds, S., Dryer, K., Bollback, J. P., Uy, J. A., Patricelli, G., Robson,
    T., … Braun, M. (2007). Behavioral paternity predicts genetic paternity in satin
    bowerbirds, a species with a non-resource-based mating system. <i>The Auk</i>.
    University of California Press. <a href="https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2">https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2</a>
  chicago: Reynolds, Sheila, Katie Dryer, Jonathan P Bollback, J Albert Uy, Gail Patricelli,
    Timothy Robson, Gerald Borgia, and Michael Braun. “Behavioral Paternity Predicts
    Genetic Paternity in Satin Bowerbirds, a Species with a Non-Resource-Based Mating
    System.” <i>The Auk</i>. University of California Press, 2007. <a href="https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2">https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2</a>.
  ieee: S. Reynolds <i>et al.</i>, “Behavioral paternity predicts genetic paternity
    in satin bowerbirds, a species with a non-resource-based mating system,” <i>The
    Auk</i>, vol. 124, no. 3. University of California Press, pp. 857–867, 2007.
  ista: Reynolds S, Dryer K, Bollback JP, Uy JA, Patricelli G, Robson T, Borgia G,
    Braun M. 2007. Behavioral paternity predicts genetic paternity in satin bowerbirds,
    a species with a non-resource-based mating system. The Auk. 124(3), 857–867.
  mla: Reynolds, Sheila, et al. “Behavioral Paternity Predicts Genetic Paternity in
    Satin Bowerbirds, a Species with a Non-Resource-Based Mating System.” <i>The Auk</i>,
    vol. 124, no. 3, University of California Press, 2007, pp. 857–67, doi:<a href="https://doi.org/10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2">10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2</a>.
  short: S. Reynolds, K. Dryer, J.P. Bollback, J.A. Uy, G. Patricelli, T. Robson,
    G. Borgia, M. Braun, The Auk 124 (2007) 857–867.
date_created: 2018-12-11T12:03:19Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:43:27Z
day: '01'
doi: 10.1642/0004-8038(2007)124[857:BPPGPI]2.0.CO;2
extern: 1
intvolume: '       124'
issue: '3'
month: '01'
page: 857 - 867
publication: The Auk
publication_status: published
publisher: University of California Press
publist_id: '2964'
quality_controlled: 0
status: public
title: Behavioral paternity predicts genetic paternity in satin bowerbirds, a species
  with a non-resource-based mating system
type: journal_article
volume: 124
year: '2007'
...
---
_id: '3450'
author:
- first_name: Peter M
  full_name: Peter Jonas
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: György
  full_name: Buzsáki, György
  last_name: Buzsáki
citation:
  ama: Jonas PM, Buzsáki G. Neural inhibition. <i>Scholarpedia</i>. 2007;2. doi:<a
    href="https://doi.org/10.4249/scholarpedia.3286">10.4249/scholarpedia.3286</a>
  apa: Jonas, P. M., &#38; Buzsáki, G. (2007). Neural inhibition. <i>Scholarpedia</i>.
    Scholarpedia. <a href="https://doi.org/10.4249/scholarpedia.3286">https://doi.org/10.4249/scholarpedia.3286</a>
  chicago: Jonas, Peter M, and György Buzsáki. “Neural Inhibition.” <i>Scholarpedia</i>.
    Scholarpedia, 2007. <a href="https://doi.org/10.4249/scholarpedia.3286">https://doi.org/10.4249/scholarpedia.3286</a>.
  ieee: P. M. Jonas and G. Buzsáki, “Neural inhibition,” <i>Scholarpedia</i>, vol.
    2. Scholarpedia, 2007.
  ista: Jonas PM, Buzsáki G. 2007. Neural inhibition. Scholarpedia. 2.
  mla: Jonas, Peter M., and György Buzsáki. “Neural Inhibition.” <i>Scholarpedia</i>,
    vol. 2, Scholarpedia, 2007, doi:<a href="https://doi.org/10.4249/scholarpedia.3286">10.4249/scholarpedia.3286</a>.
  short: P.M. Jonas, G. Buzsáki, Scholarpedia 2 (2007).
date_created: 2018-12-11T12:03:23Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:43:32Z
day: '01'
doi: 10.4249/scholarpedia.3286
extern: 1
intvolume: '         2'
month: '01'
publication: Scholarpedia
publication_status: published
publisher: Scholarpedia
publist_id: '2937'
quality_controlled: 0
status: public
title: Neural inhibition
type: journal_article
volume: 2
year: '2007'
...
---
_id: '3523'
abstract:
- lang: eng
  text: On the linear track, the recent firing sequences of CA1 place cells recur
    during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster &amp;
    Wilson (2006) Nature, 440, 680-683]. We have found similar reverse-order reactivation
    during SWRs in open-field exploration where the firing sequence of cells varied
    before each SWR. Both the onset times and the firing patterns of cells showed
    a tendency for reversed sequences during SWRs. These effects were observed for
    SWRs that occurred during exploration, but not for those during longer immobility
    periods. Additionally, reverse reactivation was stronger when it was preceded
    by higher speed (&gt; 5 cm/s) run periods. The trend for reverse-order SWR reactivation
    was not significantly different in familiar and novel environments, even though
    SWR-associated firing rates of both pyramidal cells and interneurons were reduced
    in novel environments as compared with familiar. During exploration-associated
    SWRs (eSWR) place cells retain place-selective firing [O'Neill et al. (2006) Neuron,
    49, 143-155]. Here, we have shown that each cell's firing onset was more delayed
    and firing probability more reduced during eSWRs the further the rat was from
    the middle of the cell's place field; that is, cells receiving less momentary
    place-related excitatory drive fired later during SWR events. However, even controlling
    for place field distance, the recent firing of cells was still significantly correlated
    with SWR reactivation sequences. We therefore propose that both place-related
    drive and the firing history of cells contribute to reverse reactivation during
    eSWRs.
author:
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Joseph
  full_name: Joseph O'Neill
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Kevin
  full_name: Allen, Kevin
  last_name: Allen
- first_name: Timothy
  full_name: Senior,Timothy
  last_name: Senior
citation:
  ama: Csicsvari JL, O’Neill J, Allen K, Senior T. Place-selective firing contributes
    to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
    open-field exploration. <i>European Journal of Neuroscience</i>. 2007;26(3):704-716.
    doi:<a href="https://doi.org/10.1111/j.1460-9568.2007.05684.x">10.1111/j.1460-9568.2007.05684.x</a>
  apa: Csicsvari, J. L., O’Neill, J., Allen, K., &#38; Senior, T. (2007). Place-selective
    firing contributes to the reverse-order reactivation of CA1 pyramidal cells during
    sharp waves in open-field exploration. <i>European Journal of Neuroscience</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1460-9568.2007.05684.x">https://doi.org/10.1111/j.1460-9568.2007.05684.x</a>
  chicago: Csicsvari, Jozsef L, Joseph O’Neill, Kevin Allen, and Timothy Senior. “Place-Selective
    Firing Contributes to the Reverse-Order Reactivation of CA1 Pyramidal Cells during
    Sharp Waves in Open-Field Exploration.” <i>European Journal of Neuroscience</i>.
    Wiley-Blackwell, 2007. <a href="https://doi.org/10.1111/j.1460-9568.2007.05684.x">https://doi.org/10.1111/j.1460-9568.2007.05684.x</a>.
  ieee: J. L. Csicsvari, J. O’Neill, K. Allen, and T. Senior, “Place-selective firing
    contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp
    waves in open-field exploration,” <i>European Journal of Neuroscience</i>, vol.
    26, no. 3. Wiley-Blackwell, pp. 704–716, 2007.
  ista: Csicsvari JL, O’Neill J, Allen K, Senior T. 2007. Place-selective firing contributes
    to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
    open-field exploration. European Journal of Neuroscience. 26(3), 704–716.
  mla: Csicsvari, Jozsef L., et al. “Place-Selective Firing Contributes to the Reverse-Order
    Reactivation of CA1 Pyramidal Cells during Sharp Waves in Open-Field Exploration.”
    <i>European Journal of Neuroscience</i>, vol. 26, no. 3, Wiley-Blackwell, 2007,
    pp. 704–16, doi:<a href="https://doi.org/10.1111/j.1460-9568.2007.05684.x">10.1111/j.1460-9568.2007.05684.x</a>.
  short: J.L. Csicsvari, J. O’Neill, K. Allen, T. Senior, European Journal of Neuroscience
    26 (2007) 704–716.
date_created: 2018-12-11T12:03:46Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2021-01-12T07:44:03Z
day: '01'
doi: 10.1111/j.1460-9568.2007.05684.x
extern: 1
intvolume: '        26'
issue: '3'
month: '08'
page: 704 - 716
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2862'
quality_controlled: 0
status: public
title: Place-selective firing contributes to the reverse-order reactivation of CA1
  pyramidal cells during sharp waves in open-field exploration
type: journal_article
volume: 26
year: '2007'
...
---
_id: '3561'
abstract:
- lang: eng
  text: The main result of this paper is an extension of de Silva's Weak Delaunay
    Theorem to smoothly embedded curves and surfaces in Euclidean space. Assuming
    a sufficiently fine sampling, we prove that i + 1 points in the sample span an
    i-simplex in the restricted Delaunay triangulation iff every subset of the i +
    1 points has a weak witness.
author:
- first_name: Dominique
  full_name: Attali, Dominique
  last_name: Attali
- first_name: Herbert
  full_name: Herbert Edelsbrunner
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Yuriy
  full_name: Mileyko, Yuriy
  last_name: Mileyko
citation:
  ama: 'Attali D, Edelsbrunner H, Mileyko Y. Weak witnesses for Delaunay triangulations
    of submanifolds. In: ACM; 2007:143-150. doi:<a href="https://doi.org/10.1145/1236246.1236267">10.1145/1236246.1236267</a>'
  apa: 'Attali, D., Edelsbrunner, H., &#38; Mileyko, Y. (2007). Weak witnesses for
    Delaunay triangulations of submanifolds (pp. 143–150). Presented at the SPM: Symposium
    on Solid and Physical Modeling, ACM. <a href="https://doi.org/10.1145/1236246.1236267">https://doi.org/10.1145/1236246.1236267</a>'
  chicago: Attali, Dominique, Herbert Edelsbrunner, and Yuriy Mileyko. “Weak Witnesses
    for Delaunay Triangulations of Submanifolds,” 143–50. ACM, 2007. <a href="https://doi.org/10.1145/1236246.1236267">https://doi.org/10.1145/1236246.1236267</a>.
  ieee: 'D. Attali, H. Edelsbrunner, and Y. Mileyko, “Weak witnesses for Delaunay
    triangulations of submanifolds,” presented at the SPM: Symposium on Solid and
    Physical Modeling, 2007, pp. 143–150.'
  ista: 'Attali D, Edelsbrunner H, Mileyko Y. 2007. Weak witnesses for Delaunay triangulations
    of submanifolds. SPM: Symposium on Solid and Physical Modeling, 143–150.'
  mla: Attali, Dominique, et al. <i>Weak Witnesses for Delaunay Triangulations of
    Submanifolds</i>. ACM, 2007, pp. 143–50, doi:<a href="https://doi.org/10.1145/1236246.1236267">10.1145/1236246.1236267</a>.
  short: D. Attali, H. Edelsbrunner, Y. Mileyko, in:, ACM, 2007, pp. 143–150.
conference:
  name: 'SPM: Symposium on Solid and Physical Modeling'
date_created: 2018-12-11T12:03:58Z
date_published: 2007-06-01T00:00:00Z
date_updated: 2021-01-12T07:44:19Z
day: '01'
doi: 10.1145/1236246.1236267
extern: 1
main_file_link:
- open_access: '1'
  url: https://hal.archives-ouvertes.fr/hal-00201055
month: '06'
oa: 1
page: 143 - 150
publication_status: published
publisher: ACM
publist_id: '2824'
quality_controlled: 0
status: public
title: Weak witnesses for Delaunay triangulations of submanifolds
type: conference
year: '2007'
...
---
_id: '3601'
abstract:
- lang: eng
  text: In this paper, the multiobjective optimal design of space-based reconfigurable
    sensor networks with novel adaptive MEMS antennas is investigated by using multiobjective
    evolutionary algorithms. The non-dominated sorting genetic algorithm II (NSGA-II)
    is employed to obtain multi-criteria Pareto-optimal solutions, which allows system
    designers to easily make a reasonable trade-off choice from the set of non-dominated
    solutions according to their preferences and system requirements. As a case study,
    a cluster-based satellite sensing network is simulated under multiple objectives.
    Most importantly, this paper also presents the application of our newly designed
    adaptive MEMS antennas together with the NSGA-II to the multiobjective optimal
    design of space-based reconfigurable sensor networks.
author:
- first_name: Erfu
  full_name: Yang, Erfu
  last_name: Yang
- first_name: Nakul
  full_name: Haridas, Nakul
  last_name: Haridas
- first_name: Ahmed
  full_name: El-Rayis, Ahmed O
  last_name: El Rayis
- first_name: Ahmet
  full_name: Erdogan, Ahmet T
  last_name: Erdogan
- first_name: Tughrul
  full_name: Arslan, Tughrul
  last_name: Arslan
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Yang E, Haridas N, El Rayis A, Erdogan A, Arslan T, Barton NH. Multiobjective
    optimal design of MEMS-based reconfigurable and evolvable sensor networks for
    space applications. In: IEEE; 2007:27-34. doi:<a href="https://doi.org/10.1109/AHS.2007.76">10.1109/AHS.2007.76</a>'
  apa: 'Yang, E., Haridas, N., El Rayis, A., Erdogan, A., Arslan, T., &#38; Barton,
    N. H. (2007). Multiobjective optimal design of MEMS-based reconfigurable and evolvable
    sensor networks for space applications (pp. 27–34). Presented at the AHS: NASA/ESA
    Conference on Adaptive Hardware and Systems, IEEE. <a href="https://doi.org/10.1109/AHS.2007.76">https://doi.org/10.1109/AHS.2007.76</a>'
  chicago: Yang, Erfu, Nakul Haridas, Ahmed El Rayis, Ahmet Erdogan, Tughrul Arslan,
    and Nicholas H Barton. “Multiobjective Optimal Design of MEMS-Based Reconfigurable
    and Evolvable Sensor Networks for Space Applications,” 27–34. IEEE, 2007. <a href="https://doi.org/10.1109/AHS.2007.76">https://doi.org/10.1109/AHS.2007.76</a>.
  ieee: 'E. Yang, N. Haridas, A. El Rayis, A. Erdogan, T. Arslan, and N. H. Barton,
    “Multiobjective optimal design of MEMS-based reconfigurable and evolvable sensor
    networks for space applications,” presented at the AHS: NASA/ESA Conference on
    Adaptive Hardware and Systems, 2007, pp. 27–34.'
  ista: 'Yang E, Haridas N, El Rayis A, Erdogan A, Arslan T, Barton NH. 2007. Multiobjective
    optimal design of MEMS-based reconfigurable and evolvable sensor networks for
    space applications. AHS: NASA/ESA Conference on Adaptive Hardware and Systems,
    27–34.'
  mla: Yang, Erfu, et al. <i>Multiobjective Optimal Design of MEMS-Based Reconfigurable
    and Evolvable Sensor Networks for Space Applications</i>. IEEE, 2007, pp. 27–34,
    doi:<a href="https://doi.org/10.1109/AHS.2007.76">10.1109/AHS.2007.76</a>.
  short: E. Yang, N. Haridas, A. El Rayis, A. Erdogan, T. Arslan, N.H. Barton, in:,
    IEEE, 2007, pp. 27–34.
conference:
  name: 'AHS: NASA/ESA Conference on Adaptive Hardware and Systems'
date_created: 2018-12-11T12:04:11Z
date_published: 2007-08-20T00:00:00Z
date_updated: 2021-01-12T07:44:35Z
day: '20'
doi: 10.1109/AHS.2007.76
extern: 1
month: '08'
page: 27 - 34
publication_status: published
publisher: IEEE
publist_id: '2782'
quality_controlled: 0
status: public
title: Multiobjective optimal design of MEMS-based reconfigurable and evolvable sensor
  networks for space applications
type: conference
year: '2007'
...
---
_id: '3674'
abstract:
- lang: eng
  text: "Evolution permeates all of biology. But researchers in molecular and cellular
    biology, genetics, developmental biology, microbiology, and neuroscience have
    only recently begun to think seriously in terms of evolution. The chief reasons
    for this shift are the growing list of organisms with sequenced genomes; the increasingly
    sophisticated ways of interpreting those sequences; and the ever more powerful
    experimental techniques (and wider range of model organisms) with which to ask
    questions about evolution as well as mechanism.\r\n\r\nEvolution serves as a primary
    text for undergraduate and graduate courses in evolution. It is also a text working
    scientists can use to educate themselves on how evolution affects their fields.
    It differs from currently available alternatives in containing more molecular
    biology than is traditionally the case. But this is not at the expense of traditional
    evolutionary theory. Indeed, a glance at the Table of Contents and the authors'
    interests reveals the range of material covered in this book. The authors are
    world-renowned in population genetics, bacterial genomics, paleontology, human
    genetics, and developmental biology. The integration of molecular biology and
    evolutionary biology reflects the current direction of much research among evolutionary
    scientists."
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Derek
  full_name: Briggs, Derek
  last_name: Briggs
- first_name: Jonathan
  full_name: Eisen, Jonathan
  last_name: Eisen
- first_name: David
  full_name: Goldstein, David
  last_name: Goldstein
- first_name: Nipam
  full_name: Patel, Nipam
  last_name: Patel
citation:
  ama: Barton NH, Briggs D, Eisen J, Goldstein D, Patel N. <i>Evolution</i>. Cold
    Spring Harbor Laboratory Press; 2007.
  apa: Barton, N. H., Briggs, D., Eisen, J., Goldstein, D., &#38; Patel, N. (2007).
    <i>Evolution</i>. Cold Spring Harbor Laboratory Press.
  chicago: Barton, Nicholas H, Derek Briggs, Jonathan Eisen, David Goldstein, and
    Nipam Patel. <i>Evolution</i>. Cold Spring Harbor Laboratory Press, 2007.
  ieee: N. H. Barton, D. Briggs, J. Eisen, D. Goldstein, and N. Patel, <i>Evolution</i>.
    Cold Spring Harbor Laboratory Press, 2007.
  ista: Barton NH, Briggs D, Eisen J, Goldstein D, Patel N. 2007. Evolution, Cold
    Spring Harbor Laboratory Press, XIV, 833p.
  mla: Barton, Nicholas H., et al. <i>Evolution</i>. Cold Spring Harbor Laboratory
    Press, 2007.
  short: N.H. Barton, D. Briggs, J. Eisen, D. Goldstein, N. Patel, Evolution, Cold
    Spring Harbor Laboratory Press, 2007.
date_created: 2018-12-11T12:04:33Z
date_published: 2007-06-30T00:00:00Z
date_updated: 2021-12-21T15:55:28Z
day: '30'
extern: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: XIV, 833
publication_identifier:
  isbn:
  - 978-087969684-9
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '2709'
quality_controlled: '1'
related_material:
  link:
  - description: available via catalog IST BookList
    relation: other
    url: https://koha.app.ist.ac.at/cgi-bin/koha/opac-detail.pl?biblionumber=3251&query_desc=au%2Cwrdl%3A%20nicholas%20barton
  - relation: supplementary_material
    url: http://www.evolution-textbook.org/
status: public
title: Evolution
type: book
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2007'
...
---
_id: '3681'
abstract:
- lang: eng
  text: |-
    The extraction of a parametric global motion from a motion field is a task with several applications in video processing. We present two probabilistic formulations of the problem and carry out optimization using the RAST algorithm, a geometric matching method novel to motion estimation in video. RAST uses an exhaustive and adaptive search of transformation space and thus gives – in contrast to local sampling optimization techniques used in the past – a globally optimal solution. Among other applications, our framework can thus be used as a source of ground truth for benchmarking motion estimation algorithms.

    Our main contributions are: first, the novel combination of a state-of-the-art MAP criterion for dominant motion estimation with a search procedure that guarantees global optimality. Second, experimental results that illustrate the superior performance of our approach on synthetic flow fields as well as real-world video streams. Third, a significant speedup of the search achieved by extending the model with an additional smoothness prior.
alternative_title:
- LCNS
author:
- first_name: Adrian
  full_name: Ulges, Adrian
  last_name: Ulges
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Daniel
  full_name: Keysers,Daniel
  last_name: Keysers
- first_name: Thomas
  full_name: Breuel,Thomas M
  last_name: Breuel
citation:
  ama: 'Ulges A, Lampert C, Keysers D, Breuel T. Optimal dominant motion estimation
    using adaptive search of transformation space. In: Vol 4713. Springer; 2007:204-213.
    doi:<a href="https://doi.org/10.1007/978-3-540-74936-3_21">10.1007/978-3-540-74936-3_21</a>'
  apa: 'Ulges, A., Lampert, C., Keysers, D., &#38; Breuel, T. (2007). Optimal dominant
    motion estimation using adaptive search of transformation space (Vol. 4713, pp.
    204–213). Presented at the DAGM: German Association For Pattern Recognition, Springer.
    <a href="https://doi.org/10.1007/978-3-540-74936-3_21">https://doi.org/10.1007/978-3-540-74936-3_21</a>'
  chicago: Ulges, Adrian, Christoph Lampert, Daniel Keysers, and Thomas Breuel. “Optimal
    Dominant Motion Estimation Using Adaptive Search of Transformation Space,” 4713:204–13.
    Springer, 2007. <a href="https://doi.org/10.1007/978-3-540-74936-3_21">https://doi.org/10.1007/978-3-540-74936-3_21</a>.
  ieee: 'A. Ulges, C. Lampert, D. Keysers, and T. Breuel, “Optimal dominant motion
    estimation using adaptive search of transformation space,” presented at the DAGM:
    German Association For Pattern Recognition, 2007, vol. 4713, pp. 204–213.'
  ista: 'Ulges A, Lampert C, Keysers D, Breuel T. 2007. Optimal dominant motion estimation
    using adaptive search of transformation space. DAGM: German Association For Pattern
    Recognition, LCNS, vol. 4713, 204–213.'
  mla: Ulges, Adrian, et al. <i>Optimal Dominant Motion Estimation Using Adaptive
    Search of Transformation Space</i>. Vol. 4713, Springer, 2007, pp. 204–13, doi:<a
    href="https://doi.org/10.1007/978-3-540-74936-3_21">10.1007/978-3-540-74936-3_21</a>.
  short: A. Ulges, C. Lampert, D. Keysers, T. Breuel, in:, Springer, 2007, pp. 204–213.
conference:
  name: 'DAGM: German Association For Pattern Recognition'
date_created: 2018-12-11T12:04:35Z
date_published: 2007-11-09T00:00:00Z
date_updated: 2021-01-12T07:45:06Z
day: '09'
doi: 10.1007/978-3-540-74936-3_21
extern: 1
intvolume: '      4713'
month: '11'
page: 204 - 213
publication_status: published
publisher: Springer
publist_id: '2695'
quality_controlled: 0
status: public
title: Optimal dominant motion estimation using adaptive search of transformation
  space
type: conference
volume: 4713
year: '2007'
...
---
_id: '3687'
abstract:
- lang: eng
  text: |-
    Recent years have seen huge advances in object recognition from images. Recognition rates beyond 95% are the rule rather than the exception on many datasets. However, most state-of-the-art methods can only decide if an object is present or not. They are not able to provide information on the object location or extent within in the image.

    We report on a simple yet powerful scheme that extends many existing recognition methods to also perform localization of object bounding boxes. This is achieved by maximizing the classification score over all possible subrectangles in the image. Despite the impression that this would be computationally intractable, we show that in many situations efficient algorithms exist which solve a generalized maximum subrectangle problem.

    We show how our method is applicable to a variety object detection frameworks and demonstrate its performance by applying it to the popular bag of visual words model, achieving competitive results on the PASCAL VOC 2006 dataset.
author:
- first_name: Matthew
  full_name: Blaschko,Matthew B
  last_name: Blaschko
- first_name: Thomas
  full_name: Hofmann,Thomas
  last_name: Hofmann
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: Blaschko M, Hofmann T, Lampert C. <i>Efficient Subwindow Search for Object
    Localization</i>. Max-Planck-Institute for Biological Cybernetics; 2007.
  apa: Blaschko, M., Hofmann, T., &#38; Lampert, C. (2007). <i>Efficient subwindow
    search for object localization</i>. <i>Unknown</i>. Max-Planck-Institute for Biological
    Cybernetics.
  chicago: Blaschko, Matthew, Thomas Hofmann, and Christoph Lampert. <i>Efficient
    Subwindow Search for Object Localization</i>. <i>Unknown</i>. Max-Planck-Institute
    for Biological Cybernetics, 2007.
  ieee: M. Blaschko, T. Hofmann, and C. Lampert, <i>Efficient subwindow search for
    object localization</i>, no. 164. Max-Planck-Institute for Biological Cybernetics,
    2007.
  ista: Blaschko M, Hofmann T, Lampert C. 2007. Efficient subwindow search for object
    localization, Max-Planck-Institute for Biological Cybernetics,p.
  mla: Blaschko, Matthew, et al. “Efficient Subwindow Search for Object Localization.”
    <i>Unknown</i>, no. 164, Max-Planck-Institute for Biological Cybernetics, 2007.
  short: M. Blaschko, T. Hofmann, C. Lampert, Efficient Subwindow Search for Object
    Localization, Max-Planck-Institute for Biological Cybernetics, 2007.
date_created: 2018-12-11T12:04:37Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2019-04-26T07:22:33Z
day: '01'
extern: 1
issue: '164'
main_file_link:
- open_access: '0'
  url: http://www.kyb.tuebingen.mpg.de/fileadmin/user_upload/files/publications/TR-164_[0].pdf
month: '08'
publication: Unknown
publication_status: published
publisher: Max-Planck-Institute for Biological Cybernetics
publist_id: '2681'
quality_controlled: 0
status: public
title: Efficient subwindow search for object localization
type: report
year: '2007'
...
---
_id: '3701'
abstract:
- lang: eng
  text: |-
    The extraction of a parametric global motion from a motion field is a task with several applications in video processing. We present two probabilistic formulations of the problem and carry out optimization using the RAST algorithm, a geometric matching method novel to motion estimation in video. RAST uses an exhaustive and adaptive search of transformation space and thus gives – in contrast to local sampling optimization techniques used in the past – a globally optimal solution. Among other applications, our framework can thus be used as a source of ground truth for benchmarking motion estimation algorithms.

    Our main contributions are: first, the novel combination of a state-of-the-art MAP criterion for dominant motion estimation with a search procedure that guarantees global optimality. Second, experimental results that illustrate the superior performance of our approach on synthetic flow fields as well as real-world video streams. Third, a significant speedup of the search achieved by extending the model with an additional smoothness prior.
alternative_title:
- LNCS
author:
- first_name: Adrian
  full_name: Ulges, Adrian
  last_name: Ulges
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Daniel
  full_name: Keysers,Daniel
  last_name: Keysers
- first_name: Thomas
  full_name: Breuel,Thomas M
  last_name: Breuel
citation:
  ama: 'Ulges A, Lampert C, Keysers D, Breuel T. Optimal dominant motion estimation
    using adaptive search of transformation space. In: Vol 4713. Springer; 2007:204-213.
    doi:<a href="https://doi.org/10.1007/978-3-540-74936-3_21">10.1007/978-3-540-74936-3_21</a>'
  apa: 'Ulges, A., Lampert, C., Keysers, D., &#38; Breuel, T. (2007). Optimal dominant
    motion estimation using adaptive search of transformation space (Vol. 4713, pp.
    204–213). Presented at the DAGM: German Association For Pattern Recognition, Springer.
    <a href="https://doi.org/10.1007/978-3-540-74936-3_21">https://doi.org/10.1007/978-3-540-74936-3_21</a>'
  chicago: Ulges, Adrian, Christoph Lampert, Daniel Keysers, and Thomas Breuel. “Optimal
    Dominant Motion Estimation Using Adaptive Search of Transformation Space,” 4713:204–13.
    Springer, 2007. <a href="https://doi.org/10.1007/978-3-540-74936-3_21">https://doi.org/10.1007/978-3-540-74936-3_21</a>.
  ieee: 'A. Ulges, C. Lampert, D. Keysers, and T. Breuel, “Optimal dominant motion
    estimation using adaptive search of transformation space,” presented at the DAGM:
    German Association For Pattern Recognition, 2007, vol. 4713, pp. 204–213.'
  ista: 'Ulges A, Lampert C, Keysers D, Breuel T. 2007. Optimal dominant motion estimation
    using adaptive search of transformation space. DAGM: German Association For Pattern
    Recognition, LNCS, vol. 4713, 204–213.'
  mla: Ulges, Adrian, et al. <i>Optimal Dominant Motion Estimation Using Adaptive
    Search of Transformation Space</i>. Vol. 4713, Springer, 2007, pp. 204–13, doi:<a
    href="https://doi.org/10.1007/978-3-540-74936-3_21">10.1007/978-3-540-74936-3_21</a>.
  short: A. Ulges, C. Lampert, D. Keysers, T. Breuel, in:, Springer, 2007, pp. 204–213.
conference:
  name: 'DAGM: German Association For Pattern Recognition'
date_created: 2018-12-11T12:04:42Z
date_published: 2007-11-09T00:00:00Z
date_updated: 2021-01-12T07:51:35Z
day: '09'
doi: 10.1007/978-3-540-74936-3_21
extern: 1
intvolume: '      4713'
month: '11'
page: 204 - 213
publication_status: published
publisher: Springer
publist_id: '2656'
quality_controlled: 0
status: public
title: Optimal dominant motion estimation using adaptive search of transformation
  space
type: conference
volume: 4713
year: '2007'
...
---
_id: '3723'
abstract:
- lang: eng
  text: 'The folding and function of proteins is guided by their multidimensional
    energy landscapes. Local corrugations on rugged energy surfaces determine the
    dynamics of functionally related conformational changes and molecular flexibilities.
    By varying the temperature during the force-induced unfolding of the membrane
    protein bacteriorhodopsin, we directly determined the energy roughness of individual
    transmembrane α-helices. All helices have rugged energy surfaces with an overall
    roughness scale of 4−6 kBT, in line with the vital roles of transmembrane helices
    as functional and structural building blocks. Interestingly, the mechanical unfolding
    of misfolded membrane proteins in vivo is likely to occur on similarly energy
    rugged surfaces, which may also provide an energetic framework for small vertical
    motions of functionally relevant helices. Finally, our results also indicate that
    transmembrane protein structures can have rough energy surfaces despite their
    highly restricted conformational spaces in confining lipid bilayer environments. '
author:
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Helene
  full_name: Knaus, Helene
  last_name: Knaus
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
citation:
  ama: Janovjak HL, Knaus H, Mueller D. Transmembrane helices have rough energy surfaces.
    <i>Journal of the American Chemical Society</i>. 2007;129(2):246-247. doi:<a href="https://doi.org/10.1021/ja065684a">10.1021/ja065684a</a>
  apa: Janovjak, H. L., Knaus, H., &#38; Mueller, D. (2007). Transmembrane helices
    have rough energy surfaces. <i>Journal of the American Chemical Society</i>. ACS.
    <a href="https://doi.org/10.1021/ja065684a">https://doi.org/10.1021/ja065684a</a>
  chicago: Janovjak, Harald L, Helene Knaus, and Daniel Mueller. “Transmembrane Helices
    Have Rough Energy Surfaces.” <i>Journal of the American Chemical Society</i>.
    ACS, 2007. <a href="https://doi.org/10.1021/ja065684a">https://doi.org/10.1021/ja065684a</a>.
  ieee: H. L. Janovjak, H. Knaus, and D. Mueller, “Transmembrane helices have rough
    energy surfaces,” <i>Journal of the American Chemical Society</i>, vol. 129, no.
    2. ACS, pp. 246–247, 2007.
  ista: Janovjak HL, Knaus H, Mueller D. 2007. Transmembrane helices have rough energy
    surfaces. Journal of the American Chemical Society. 129(2), 246–247.
  mla: Janovjak, Harald L., et al. “Transmembrane Helices Have Rough Energy Surfaces.”
    <i>Journal of the American Chemical Society</i>, vol. 129, no. 2, ACS, 2007, pp.
    246–47, doi:<a href="https://doi.org/10.1021/ja065684a">10.1021/ja065684a</a>.
  short: H.L. Janovjak, H. Knaus, D. Mueller, Journal of the American Chemical Society
    129 (2007) 246–247.
date_created: 2018-12-11T12:04:49Z
date_published: 2007-01-17T00:00:00Z
date_updated: 2021-01-12T07:51:44Z
day: '17'
doi: 10.1021/ja065684a
extern: 1
intvolume: '       129'
issue: '2'
month: '01'
page: 246 - 247
publication: Journal of the American Chemical Society
publication_status: published
publisher: ACS
publist_id: '2507'
quality_controlled: 0
status: public
title: Transmembrane helices have rough energy surfaces
type: journal_article
volume: 129
year: '2007'
...
---
_id: '3727'
abstract:
- lang: eng
  text: Since its invention in the 1990s single-molecule force spectroscopy has been
    increasingly applied to study protein (un-)folding, cell adhesion, and ligand–receptor
    interactions. In most force spectroscopy studies, the cantilever of an atomic
    force microscope (AFM) is separated from a surface at a constant velocity, thus
    applying an increasing force to folded bio-molecules or bio-molecular bonds. Recently,
    Fernandez and co-workers introduced the so-called force-clamp technique. Single
    proteins were subjected to a defined constant force allowing their life times
    and life time distributions to be directly measured. Up to now, the force-clamping
    was performed by analogue PID controllers, which require complex additional hardware
    and might make it difficult to combine the force-feedback with other modes such
    as constant velocity. These points may be limiting the applicability and versatility
    of this technique. Here we present a simple, fast, and all-digital (software-based)
    PID controller that yields response times of a few milliseconds in combination
    with a commercial AFM. We demonstrate the performance of our feedback loop by
    force-clamp unfolding of single Ig27 domains of titin and the membrane proteins
    bacteriorhodopsin (BR) and the sodium/proton antiporter NhaA.
author:
- first_name: Christian
  full_name: Bippes, Christian A
  last_name: Bippes
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Alexej
  full_name: Kedrov, Alexej
  last_name: Kedrov
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
citation:
  ama: Bippes C, Janovjak HL, Kedrov A, Mueller D. Digital force-feedback for protein
    unfolding experiments using atomic force microscopy. <i>Nanotechnology</i>. 2007;18(4).
    doi:<a href="https://doi.org/10.1088/0957-4484/18/4/044022">10.1088/0957-4484/18/4/044022</a>
  apa: Bippes, C., Janovjak, H. L., Kedrov, A., &#38; Mueller, D. (2007). Digital
    force-feedback for protein unfolding experiments using atomic force microscopy.
    <i>Nanotechnology</i>. IOP Publishing Ltd. <a href="https://doi.org/10.1088/0957-4484/18/4/044022">https://doi.org/10.1088/0957-4484/18/4/044022</a>
  chicago: Bippes, Christian, Harald L Janovjak, Alexej Kedrov, and Daniel Mueller.
    “Digital Force-Feedback for Protein Unfolding Experiments Using Atomic Force Microscopy.”
    <i>Nanotechnology</i>. IOP Publishing Ltd., 2007. <a href="https://doi.org/10.1088/0957-4484/18/4/044022">https://doi.org/10.1088/0957-4484/18/4/044022</a>.
  ieee: C. Bippes, H. L. Janovjak, A. Kedrov, and D. Mueller, “Digital force-feedback
    for protein unfolding experiments using atomic force microscopy,” <i>Nanotechnology</i>,
    vol. 18, no. 4. IOP Publishing Ltd., 2007.
  ista: Bippes C, Janovjak HL, Kedrov A, Mueller D. 2007. Digital force-feedback for
    protein unfolding experiments using atomic force microscopy. Nanotechnology. 18(4).
  mla: Bippes, Christian, et al. “Digital Force-Feedback for Protein Unfolding Experiments
    Using Atomic Force Microscopy.” <i>Nanotechnology</i>, vol. 18, no. 4, IOP Publishing
    Ltd., 2007, doi:<a href="https://doi.org/10.1088/0957-4484/18/4/044022">10.1088/0957-4484/18/4/044022</a>.
  short: C. Bippes, H.L. Janovjak, A. Kedrov, D. Mueller, Nanotechnology 18 (2007).
date_created: 2018-12-11T12:04:50Z
date_published: 2007-01-31T00:00:00Z
date_updated: 2021-01-12T07:51:46Z
day: '31'
doi: 10.1088/0957-4484/18/4/044022
extern: 1
intvolume: '        18'
issue: '4'
month: '01'
publication: Nanotechnology
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '2501'
quality_controlled: 0
status: public
title: Digital force-feedback for protein unfolding experiments using atomic force
  microscopy
type: journal_article
volume: 18
year: '2007'
...
---
_id: '3731'
abstract:
- lang: eng
  text: A cell's ability to regulate gene transcription depends in large part on the
    energy with which transcription factors (TFs) bind their DNA regulatory sites.
    Obtaining accurate models of this binding energy is therefore an important goal
    for quantitative biology. In this article, we present a principled likelihood-based
    approach for inferring physical models of TF-DNA binding energy from the data
    produced by modern high-throughput binding assays. Central to our analysis is
    the ability to assess the relative likelihood of different model parameters given
    experimental observations. We take a unique approach to this problem and show
    how to compute likelihood without any explicit assumptions about the noise that
    inevitably corrupts such measurements. Sampling possible choices for model parameters
    according to this likelihood function, we can then make probabilistic predictions
    for the identities of binding sites and their physical binding energies. Applying
    this procedure to previously published data on the Saccharomyces cerevisiae TF
    Abf1p, we find models of TF binding whose parameters are determined with remarkable
    precision. Evidence for the accuracy of these models is provided by an astonishing
    level of phylogenetic conservation in the predicted energies of putative binding
    sites. Results from in vivo and in vitro experiments also provide highly consistent
    characterizations of Abf1p, a result that contrasts with a previous analysis of
    the same data.
author:
- first_name: Justin
  full_name: Kinney,Justin B
  last_name: Kinney
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Curtis
  full_name: Callan,Curtis G
  last_name: Callan
citation:
  ama: Kinney J, Tkačik G, Callan C. Precise physical models of protein-DNA interaction
    from high-throughput data. <i>PNAS</i>. 2007;104(2):501-506. doi:<a href="https://doi.org/10.1073/pnas.0609908104">10.1073/pnas.0609908104</a>
  apa: Kinney, J., Tkačik, G., &#38; Callan, C. (2007). Precise physical models of
    protein-DNA interaction from high-throughput data. <i>PNAS</i>. National Academy
    of Sciences. <a href="https://doi.org/10.1073/pnas.0609908104">https://doi.org/10.1073/pnas.0609908104</a>
  chicago: Kinney, Justin, Gašper Tkačik, and Curtis Callan. “Precise Physical Models
    of Protein-DNA Interaction from High-Throughput Data.” <i>PNAS</i>. National Academy
    of Sciences, 2007. <a href="https://doi.org/10.1073/pnas.0609908104">https://doi.org/10.1073/pnas.0609908104</a>.
  ieee: J. Kinney, G. Tkačik, and C. Callan, “Precise physical models of protein-DNA
    interaction from high-throughput data,” <i>PNAS</i>, vol. 104, no. 2. National
    Academy of Sciences, pp. 501–506, 2007.
  ista: Kinney J, Tkačik G, Callan C. 2007. Precise physical models of protein-DNA
    interaction from high-throughput data. PNAS. 104(2), 501–506.
  mla: Kinney, Justin, et al. “Precise Physical Models of Protein-DNA Interaction
    from High-Throughput Data.” <i>PNAS</i>, vol. 104, no. 2, National Academy of
    Sciences, 2007, pp. 501–06, doi:<a href="https://doi.org/10.1073/pnas.0609908104">10.1073/pnas.0609908104</a>.
  short: J. Kinney, G. Tkačik, C. Callan, PNAS 104 (2007) 501–506.
date_created: 2018-12-11T12:04:51Z
date_published: 2007-01-09T00:00:00Z
date_updated: 2021-01-12T07:51:48Z
day: '09'
doi: 10.1073/pnas.0609908104
extern: 1
intvolume: '       104'
issue: '2'
main_file_link:
- open_access: '0'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766414
month: '01'
page: 501 - 506
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2495'
quality_controlled: 0
status: public
title: Precise physical models of protein-DNA interaction from high-throughput data
type: journal_article
volume: 104
year: '2007'
...
---
_id: '3742'
abstract:
- lang: eng
  text: 'Recent work has shown that probabilistic models based on pairwise interactions-in
    the simplest case, the Ising model-provide surprisingly accurate descriptions
    of experiments on real biological networks ranging from neurons to genes. Finding
    these models requires us to solve an inverse problem: given experimentally measured
    expectation values, what are the parameters of the underlying Hamiltonian? This
    problem sits at the intersection of statistical physics and machine learning,
    and we suggest that more efficient solutions are possible by merging ideas from
    the two fields. We use a combination of recent coordinate descent algorithms with
    an adaptation of the histogram Monte Carlo method, and implement these techniques
    to take advantage of the sparseness found in data on real neurons. The resulting
    algorithm learns the parameters of an Ising model describing a network of forty
    neurons within a few minutes. This opens the possibility of analyzing much larger
    data sets now emerging, and thus testing hypotheses about the collective behaviors
    of these networks.'
author:
- first_name: Tamara
  full_name: Broderick,Tamara
  last_name: Broderick
- first_name: Miroslav
  full_name: Dudik,Miroslav
  last_name: Dudik
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Robert
  full_name: Schapire,Robert E
  last_name: Schapire
- first_name: William
  full_name: Bialek, William S
  last_name: Bialek
citation:
  ama: Broderick T, Dudik M, Tkačik G, Schapire R, Bialek W. Faster solutions of the
    inverse pairwise Ising problem. <i>ArXiv</i>. 2007;q-QM.
  apa: Broderick, T., Dudik, M., Tkačik, G., Schapire, R., &#38; Bialek, W. (2007).
    Faster solutions of the inverse pairwise Ising problem. <i>ArXiv</i>. ArXiv.
  chicago: Broderick, Tamara, Miroslav Dudik, Gašper Tkačik, Robert Schapire, and
    William Bialek. “Faster Solutions of the Inverse Pairwise Ising Problem.” <i>ArXiv</i>.
    ArXiv, 2007.
  ieee: T. Broderick, M. Dudik, G. Tkačik, R. Schapire, and W. Bialek, “Faster solutions
    of the inverse pairwise Ising problem,” <i>ArXiv</i>, vol. q-QM. ArXiv, 2007.
  ista: Broderick T, Dudik M, Tkačik G, Schapire R, Bialek W. 2007. Faster solutions
    of the inverse pairwise Ising problem. ArXiv, q-QM, .
  mla: Broderick, Tamara, et al. “Faster Solutions of the Inverse Pairwise Ising Problem.”
    <i>ArXiv</i>, vol. q-QM, ArXiv, 2007.
  short: T. Broderick, M. Dudik, G. Tkačik, R. Schapire, W. Bialek, ArXiv q-QM (2007).
date_created: 2018-12-11T12:04:55Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T07:51:52Z
day: '01'
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0712.2437v2
month: '01'
oa: 1
publication: ArXiv
publication_status: published
publisher: ArXiv
publist_id: '2486'
quality_controlled: 0
status: public
title: Faster solutions of the inverse pairwise Ising problem
type: preprint
volume: q-bio.QM
year: '2007'
...
