---
_id: '10600'
abstract:
- lang: eng
text: We show that recent results on adiabatic theory for interacting gapped many-body
systems on finite lattices remain valid in the thermodynamic limit. More precisely,
we prove a generalized super-adiabatic theorem for the automorphism group describing
the infinite volume dynamics on the quasi-local algebra of observables. The key
assumption is the existence of a sequence of gapped finite volume Hamiltonians,
which generates the same infinite volume dynamics in the thermodynamic limit.
Our adiabatic theorem also holds for certain perturbations of gapped ground states
that close the spectral gap (so it is also an adiabatic theorem for resonances
and, in this sense, “generalized”), and it provides an adiabatic approximation
to all orders in the adiabatic parameter (a property often called “super-adiabatic”).
In addition to the existing results for finite lattices, we also perform a resummation
of the adiabatic expansion and allow for observables that are not strictly local.
Finally, as an application, we prove the validity of linear and higher order response
theory for our class of perturbations for infinite systems. While we consider
the result and its proof as new and interesting in itself, we also lay the foundation
for the proof of an adiabatic theorem for systems with a gap only in the bulk,
which will be presented in a follow-up article.
acknowledgement: J.H. acknowledges partial financial support from ERC Advanced Grant
“RMTBeyond” No. 101020331.
article_number: '011901'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
citation:
ama: 'Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems
with a uniform gap. Journal of Mathematical Physics. 2022;63(1). doi:10.1063/5.0051632'
apa: 'Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic
limit: Systems with a uniform gap. Journal of Mathematical Physics. AIP
Publishing. https://doi.org/10.1063/5.0051632'
chicago: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Uniform Gap.” Journal of Mathematical Physics. AIP
Publishing, 2022. https://doi.org/10.1063/5.0051632.'
ieee: 'S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit:
Systems with a uniform gap,” Journal of Mathematical Physics, vol. 63,
no. 1. AIP Publishing, 2022.'
ista: 'Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit:
Systems with a uniform gap. Journal of Mathematical Physics. 63(1), 011901.'
mla: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Uniform Gap.” Journal of Mathematical Physics, vol.
63, no. 1, 011901, AIP Publishing, 2022, doi:10.1063/5.0051632.'
short: S.J. Henheik, S. Teufel, Journal of Mathematical Physics 63 (2022).
date_created: 2022-01-03T12:19:48Z
date_published: 2022-01-03T00:00:00Z
date_updated: 2023-08-02T13:44:32Z
day: '03'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1063/5.0051632
ec_funded: 1
external_id:
arxiv:
- '2012.15238'
isi:
- '000739446000009'
intvolume: ' 63'
isi: 1
issue: '1'
keyword:
- mathematical physics
- statistical and nonlinear physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2012.15238
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Journal of Mathematical Physics
publication_identifier:
eissn:
- 1089-7658
issn:
- 0022-2488
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
status: public
title: 'Adiabatic theorem in the thermodynamic limit: Systems with a uniform gap'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 63
year: '2022'
...
---
_id: '10602'
abstract:
- lang: eng
text: Transforming ω-automata into parity automata is traditionally done using appearance
records. We present an efficient variant of this idea, tailored to Rabin automata,
and several optimizations applicable to all appearance records. We compare the
methods experimentally and show that our method produces significantly smaller
automata than previous approaches.
acknowledgement: This work is partially funded by the German Research Foundation (DFG)
projects Verified Model Checkers (No. 317422601) and Statistical Unbounded Verification
(No. 383882557), and the Alexander von Humboldt Foundation with funds from the German
Federal Ministry of Education and Research. It is an extended version of [21], including
all proofs together with further explanations and examples. Moreover, we provide
a new, more efficient construction based on (total) preorders, unifying previous
optimizations. Experiments are performed with a new, performant implementation,
comparing our approach to the current state of the art.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jan
full_name: Kretinsky, Jan
id: 44CEF464-F248-11E8-B48F-1D18A9856A87
last_name: Kretinsky
orcid: 0000-0002-8122-2881
- first_name: Tobias
full_name: Meggendorfer, Tobias
id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
last_name: Meggendorfer
orcid: 0000-0002-1712-2165
- first_name: Clara
full_name: Waldmann, Clara
last_name: Waldmann
- first_name: Maximilian
full_name: Weininger, Maximilian
last_name: Weininger
citation:
ama: Kretinsky J, Meggendorfer T, Waldmann C, Weininger M. Index appearance record
with preorders. Acta Informatica. 2022;59:585-618. doi:10.1007/s00236-021-00412-y
apa: Kretinsky, J., Meggendorfer, T., Waldmann, C., & Weininger, M. (2022).
Index appearance record with preorders. Acta Informatica. Springer Nature.
https://doi.org/10.1007/s00236-021-00412-y
chicago: Kretinsky, Jan, Tobias Meggendorfer, Clara Waldmann, and Maximilian Weininger.
“Index Appearance Record with Preorders.” Acta Informatica. Springer Nature,
2022. https://doi.org/10.1007/s00236-021-00412-y.
ieee: J. Kretinsky, T. Meggendorfer, C. Waldmann, and M. Weininger, “Index appearance
record with preorders,” Acta Informatica, vol. 59. Springer Nature, pp.
585–618, 2022.
ista: Kretinsky J, Meggendorfer T, Waldmann C, Weininger M. 2022. Index appearance
record with preorders. Acta Informatica. 59, 585–618.
mla: Kretinsky, Jan, et al. “Index Appearance Record with Preorders.” Acta Informatica,
vol. 59, Springer Nature, 2022, pp. 585–618, doi:10.1007/s00236-021-00412-y.
short: J. Kretinsky, T. Meggendorfer, C. Waldmann, M. Weininger, Acta Informatica
59 (2022) 585–618.
date_created: 2022-01-06T12:37:27Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2023-08-02T13:49:28Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/s00236-021-00412-y
external_id:
isi:
- '000735765500001'
file:
- access_level: open_access
checksum: bf1c195b6aaf59e8530cf9e3a9d731f7
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-07T07:50:31Z
date_updated: 2022-01-07T07:50:31Z
file_id: '10603'
file_name: 2021_ActaInfor_Křetínský.pdf
file_size: 1066082
relation: main_file
success: 1
file_date_updated: 2022-01-07T07:50:31Z
has_accepted_license: '1'
intvolume: ' 59'
isi: 1
keyword:
- computer networks and communications
- information systems
- software
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '10'
oa: 1
oa_version: Published Version
page: 585-618
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Acta Informatica
publication_identifier:
eissn:
- 1432-0525
issn:
- 0001-5903
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Index appearance record with preorders
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 59
year: '2022'
...
---
_id: '10604'
abstract:
- lang: eng
text: Maternally inherited Wolbachia transinfections are being introduced into natural
mosquito populations to reduce the transmission of dengue, Zika, and other arboviruses.
Wolbachia-induced cytoplasmic incompatibility provides a frequency-dependent reproductive
advantage to infected females that can spread transinfections within and among
populations. However, because transinfections generally reduce host fitness, they
tend to spread within populations only after their frequency exceeds a critical
threshold. This produces bistability with stable equilibrium frequencies at both
0 and 1, analogous to the bistability produced by underdominance between alleles
or karyotypes and by population dynamics under Allee effects. Here, we analyze
how stochastic frequency variation produced by finite population size can facilitate
the local spread of variants with bistable dynamics into areas where invasion
is unexpected from deterministic models. Our exemplar is the establishment of
wMel Wolbachia in the Aedes aegypti population of Pyramid Estates (PE), a small
community in far north Queensland, Australia. In 2011, wMel was stably introduced
into Gordonvale, separated from PE by barriers to A. aegypti dispersal. After
nearly 6 years during which wMel was observed only at low frequencies in PE, corresponding
to an apparent equilibrium between immigration and selection, wMel rose to fixation
by 2018. Using analytic approximations and statistical analyses, we demonstrate
that the observed fixation of wMel at PE is consistent with both stochastic transition
past an unstable threshold frequency and deterministic transformation produced
by steady immigration at a rate just above the threshold required for deterministic
invasion. The indeterminacy results from a delicate balance of parameters needed
to produce the delayed transition observed. Our analyses suggest that once Wolbachia
transinfections are established locally through systematic introductions, stochastic
“threshold crossing” is likely to only minimally enhance spatial spread, providing
a local ratchet that slightly—but systematically—aids area-wide transformation
of disease-vector populations in heterogeneous landscapes.
acknowledgement: We thank S. O'Neill, C. Simmons, and the World Mosquito Project for
providing access to unpublished data. S. Ritchie provided valuable insights into
Aedes aegypti biology and the literature describing A. aegypti populations near
Cairns. We thank B. Cooper for help with the figures and D. Shropshire, S. O'Neill,
S. Ritchie, A. Hoffmann, B. Cooper, and members of the Cooper lab for comments on
an earlier draft. Comments from three reviewers greatly improved our presentation.
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Turelli M, Barton NH. Why did the Wolbachia transinfection cross the road?
Drift, deterministic dynamics, and disease control. Evolution Letters.
2022;6(1):92-105. doi:10.1002/evl3.270
apa: Turelli, M., & Barton, N. H. (2022). Why did the Wolbachia transinfection
cross the road? Drift, deterministic dynamics, and disease control. Evolution
Letters. Wiley. https://doi.org/10.1002/evl3.270
chicago: Turelli, Michael, and Nicholas H Barton. “Why Did the Wolbachia Transinfection
Cross the Road? Drift, Deterministic Dynamics, and Disease Control.” Evolution
Letters. Wiley, 2022. https://doi.org/10.1002/evl3.270.
ieee: M. Turelli and N. H. Barton, “Why did the Wolbachia transinfection cross the
road? Drift, deterministic dynamics, and disease control,” Evolution Letters,
vol. 6, no. 1. Wiley, pp. 92–105, 2022.
ista: Turelli M, Barton NH. 2022. Why did the Wolbachia transinfection cross the
road? Drift, deterministic dynamics, and disease control. Evolution Letters. 6(1),
92–105.
mla: Turelli, Michael, and Nicholas H. Barton. “Why Did the Wolbachia Transinfection
Cross the Road? Drift, Deterministic Dynamics, and Disease Control.” Evolution
Letters, vol. 6, no. 1, Wiley, 2022, pp. 92–105, doi:10.1002/evl3.270.
short: M. Turelli, N.H. Barton, Evolution Letters 6 (2022) 92–105.
date_created: 2022-01-09T09:45:17Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2023-08-02T13:50:09Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/evl3.270
external_id:
isi:
- '000754412600008'
file:
- access_level: open_access
checksum: 7e9a37e3b65b480cd7014a6a4a7e460a
content_type: application/pdf
creator: dernst
date_created: 2022-07-29T06:59:10Z
date_updated: 2022-07-29T06:59:10Z
file_id: '11689'
file_name: 2022_EvolutionLetters_Turelli.pdf
file_size: 2435185
relation: main_file
success: 1
file_date_updated: 2022-07-29T06:59:10Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '1'
keyword:
- genetics
- ecology
- evolution
- behavior and systematics
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 92-105
publication: Evolution Letters
publication_identifier:
eissn:
- 2056-3744
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '11686'
relation: research_data
status: public
status: public
title: Why did the Wolbachia transinfection cross the road? Drift, deterministic dynamics,
and disease control
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2022'
...
---
_id: '10614'
abstract:
- lang: eng
text: 'The infiltration of immune cells into tissues underlies the establishment
of tissue-resident macrophages and responses to infections and tumors. Yet the
mechanisms immune cells utilize to negotiate tissue barriers in living organisms
are not well understood, and a role for cortical actin has not been examined.
Here, we find that the tissue invasion of Drosophila macrophages, also known as
plasmatocytes or hemocytes, utilizes enhanced cortical F-actin levels stimulated
by the Drosophila member of the fos proto oncogene transcription factor family
(Dfos, Kayak). RNA sequencing analysis and live imaging show that Dfos enhances
F-actin levels around the entire macrophage surface by increasing mRNA levels
of the membrane spanning molecular scaffold tetraspanin TM4SF, and the actin cross-linking
filamin Cheerio, which are themselves required for invasion. Both the filamin
and the tetraspanin enhance the cortical activity of Rho1 and the formin Diaphanous
and thus the assembly of cortical actin, which is a critical function since expressing
a dominant active form of Diaphanous can rescue the Dfos macrophage invasion defect.
In vivo imaging shows that Dfos enhances the efficiency of the initial phases
of macrophage tissue entry. Genetic evidence argues that this Dfos-induced program
in macrophages counteracts the constraint produced by the tension of surrounding
tissues and buffers the properties of the macrophage nucleus from affecting tissue
entry. We thus identify strengthening the cortical actin cytoskeleton through
Dfos as a key process allowing efficient forward movement of an immune cell into
surrounding tissues. '
acknowledged_ssus:
- _id: LifeSc
acknowledgement: 'We thank the following for their contributions: Plasmids were supplied
by the Drosophila Genomics Resource Center (NIH 2P40OD010949-10A1); fly stocks were
provided by K. Brueckner, B. Stramer, M. Uhlirova, O. Schuldiner, the Bloomington
Drosophila Stock Center (NIH P40OD018537) and the Vienna Drosophila Resource Center,
FlyBase for essential genomic information, and the BDGP in situ database for data.
For antibodies, we thank the Developmental Studies Hybridoma Bank, which was created
by the Eunice Kennedy Shriver National Institute of Child Health and Human Development
of the NIH and is maintained at the University of Iowa, as well as J. Zeitlinger
for her generous gift of Dfos antibody. We thank the Vienna BioCenter Core Facilities
for RNA sequencing and analysis and the Life Scientific Service Units at IST Austria
for technical support and assistance with microscopy and FACS analysis. We thank
C. P. Heisenberg, P. Martin, M. Sixt, and Siekhaus group members for discussions
and T. Hurd, A. Ratheesh, and P. Rangan for comments on the manuscript.'
article_processing_charge: No
article_type: original
author:
- first_name: Vera
full_name: Belyaeva, Vera
id: 47F080FE-F248-11E8-B48F-1D18A9856A87
last_name: Belyaeva
- first_name: Stephanie
full_name: Wachner, Stephanie
id: 2A95E7B0-F248-11E8-B48F-1D18A9856A87
last_name: Wachner
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Maria
full_name: Akhmanova, Maria
id: 3425EC26-F248-11E8-B48F-1D18A9856A87
last_name: Akhmanova
orcid: 0000-0003-1522-3162
- first_name: M
full_name: Linder, M
last_name: Linder
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: M
full_name: Sibilia, M
last_name: Sibilia
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Belyaeva V, Wachner S, György A, et al. Fos regulates macrophage infiltration
against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.
PLoS Biology. 2022;20(1):e3001494. doi:10.1371/journal.pbio.3001494
apa: Belyaeva, V., Wachner, S., György, A., Emtenani, S., Gridchyn, I., Akhmanova,
M., … Siekhaus, D. E. (2022). Fos regulates macrophage infiltration against surrounding
tissue resistance by a cortical actin-based mechanism in Drosophila. PLoS Biology.
Public Library of Science. https://doi.org/10.1371/journal.pbio.3001494
chicago: Belyaeva, Vera, Stephanie Wachner, Attila György, Shamsi Emtenani, Igor
Gridchyn, Maria Akhmanova, M Linder, Marko Roblek, M Sibilia, and Daria E Siekhaus.
“Fos Regulates Macrophage Infiltration against Surrounding Tissue Resistance by
a Cortical Actin-Based Mechanism in Drosophila.” PLoS Biology. Public Library
of Science, 2022. https://doi.org/10.1371/journal.pbio.3001494.
ieee: V. Belyaeva et al., “Fos regulates macrophage infiltration against
surrounding tissue resistance by a cortical actin-based mechanism in Drosophila,”
PLoS Biology, vol. 20, no. 1. Public Library of Science, p. e3001494, 2022.
ista: Belyaeva V, Wachner S, György A, Emtenani S, Gridchyn I, Akhmanova M, Linder
M, Roblek M, Sibilia M, Siekhaus DE. 2022. Fos regulates macrophage infiltration
against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila.
PLoS Biology. 20(1), e3001494.
mla: Belyaeva, Vera, et al. “Fos Regulates Macrophage Infiltration against Surrounding
Tissue Resistance by a Cortical Actin-Based Mechanism in Drosophila.” PLoS
Biology, vol. 20, no. 1, Public Library of Science, 2022, p. e3001494, doi:10.1371/journal.pbio.3001494.
short: V. Belyaeva, S. Wachner, A. György, S. Emtenani, I. Gridchyn, M. Akhmanova,
M. Linder, M. Roblek, M. Sibilia, D.E. Siekhaus, PLoS Biology 20 (2022) e3001494.
date_created: 2022-01-12T10:18:17Z
date_published: 2022-01-06T00:00:00Z
date_updated: 2024-03-25T23:30:15Z
day: '06'
ddc:
- '570'
department:
- _id: DaSi
- _id: JoCs
doi: 10.1371/journal.pbio.3001494
ec_funded: 1
external_id:
isi:
- '000971223700001'
pmid:
- '34990456'
file:
- access_level: open_access
checksum: f454212a5522a7818ba4b2892315c478
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-12T13:50:04Z
date_updated: 2022-01-12T13:50:04Z
file_id: '10615'
file_name: 2022_PLOSBio_Belyaeva.pdf
file_size: 5426932
relation: main_file
success: 1
file_date_updated: 2022-01-12T13:50:04Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: e3001494
pmid: 1
project:
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: Drosophila TNFa´s Funktion in Immunzellen
- _id: 26199CA4-B435-11E9-9278-68D0E5697425
grant_number: '24800'
name: Tissue barrier penetration is crucial for immunity and metastasis
- _id: 2536F660-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '334077'
name: Investigating the role of transporters in invasive migration through junctions
publication: PLoS Biology
publication_identifier:
eissn:
- 1545-7885
issn:
- 1544-9173
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://www.biorxiv.org/content/10.1101/2020.09.18.301481
- description: News on the ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/resisting-the-pressure/
record:
- id: '8557'
relation: earlier_version
status: public
- id: '11193'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Fos regulates macrophage infiltration against surrounding tissue resistance
by a cortical actin-based mechanism in Drosophila
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2022'
...
---
_id: '10623'
abstract:
- lang: eng
text: We investigate the BCS critical temperature Tc in the high-density limit and
derive an asymptotic formula, which strongly depends on the behavior of the interaction
potential V on the Fermi-surface. Our results include a rigorous confirmation
for the behavior of Tc at high densities proposed by Langmann et al. (Phys Rev
Lett 122:157001, 2019) and identify precise conditions under which superconducting
domes arise in BCS theory.
acknowledgement: I am very grateful to Robert Seiringer for his guidance during this
project and for many valuable comments on an earlier version of the manuscript.
Moreover, I would like to thank Asbjørn Bækgaard Lauritsen for many helpful discussions
and comments, pointing out the reference [22] and for his involvement in a closely
related joint project [13]. Finally, I am grateful to Christian Hainzl for valuable
comments on an earlier version of the manuscript and Andreas Deuchert for interesting
discussions.
article_number: '3'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
citation:
ama: Henheik SJ. The BCS critical temperature at high density. Mathematical Physics,
Analysis and Geometry. 2022;25(1). doi:10.1007/s11040-021-09415-0
apa: Henheik, S. J. (2022). The BCS critical temperature at high density. Mathematical
Physics, Analysis and Geometry. Springer Nature. https://doi.org/10.1007/s11040-021-09415-0
chicago: Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” Mathematical
Physics, Analysis and Geometry. Springer Nature, 2022. https://doi.org/10.1007/s11040-021-09415-0.
ieee: S. J. Henheik, “The BCS critical temperature at high density,” Mathematical
Physics, Analysis and Geometry, vol. 25, no. 1. Springer Nature, 2022.
ista: Henheik SJ. 2022. The BCS critical temperature at high density. Mathematical
Physics, Analysis and Geometry. 25(1), 3.
mla: Henheik, Sven Joscha. “The BCS Critical Temperature at High Density.” Mathematical
Physics, Analysis and Geometry, vol. 25, no. 1, 3, Springer Nature, 2022,
doi:10.1007/s11040-021-09415-0.
short: S.J. Henheik, Mathematical Physics, Analysis and Geometry 25 (2022).
date_created: 2022-01-13T15:40:53Z
date_published: 2022-01-11T00:00:00Z
date_updated: 2023-08-02T13:51:52Z
day: '11'
ddc:
- '514'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1007/s11040-021-09415-0
ec_funded: 1
external_id:
arxiv:
- '2106.02015'
isi:
- '000741387600001'
file:
- access_level: open_access
checksum: d44f8123a52592a75b2c3b8ee2cd2435
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-14T07:27:45Z
date_updated: 2022-01-14T07:27:45Z
file_id: '10624'
file_name: 2022_MathPhyAnalGeo_Henheik.pdf
file_size: 505804
relation: main_file
success: 1
file_date_updated: 2022-01-14T07:27:45Z
has_accepted_license: '1'
intvolume: ' 25'
isi: 1
issue: '1'
keyword:
- geometry and topology
- mathematical physics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Mathematical Physics, Analysis and Geometry
publication_identifier:
eissn:
- 1572-9656
issn:
- 1385-0172
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The BCS critical temperature at high density
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 25
year: '2022'
...
---
_id: '10639'
abstract:
- lang: eng
text: With more than 80 members worldwide, the Orthobunyavirus genus in the Peribunyaviridae
family is a large genus of enveloped RNA viruses, many of which are emerging pathogens
in humans and livestock. How orthobunyaviruses (OBVs) penetrate and infect mammalian
host cells remains poorly characterized. Here, we investigated the entry mechanisms
of the OBV Germiston (GERV). Viral particles were visualized by cryo-electron
microscopy and appeared roughly spherical with an average diameter of 98 nm. Labeling
of the virus with fluorescent dyes did not adversely affect its infectivity and
allowed the monitoring of single particles in fixed and live cells. Using this
approach, we found that endocytic internalization of bound viruses was asynchronous
and occurred within 30-40 min. The virus entered Rab5a+ early endosomes and, subsequently,
late endosomal vacuoles containing Rab7a but not LAMP-1. Infectious entry did
not require proteolytic cleavage, and endosomal acidification was sufficient and
necessary for viral fusion. Acid-activated penetration began 15-25 min after initiation
of virus internalization and relied on maturation of early endosomes to late endosomes.
The optimal pH for viral membrane fusion was slightly below 6.0, and penetration
was hampered when the potassium influx was abolished. Overall, our study provides
real-time visualization of GERV entry into host cells and demonstrates the importance
of late endosomal maturation in facilitating OBV penetration.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: This work was supported by INRAE starter funds, Project IDEXLYON (University of Lyon)
within the Programme Investissements d’Avenir (ANR-16-IDEX-0005), and FINOVIAO14
(Fondation pour l’Université de Lyon), all to P.Y.L. This work was also supported by
CellNetworks Research Group funds and Deutsche Forschungsgemeinschaft (DFG) funding
(grant numbers LO-2338/1-1 and LO-2338/3-1) awarded to P.Y.L., Austrian Science Fund
(FWF) grant P31445 to F.K.M.S., a Chinese Scholarship Council (CSC;no. 201904910701)
fellowship to Q.X., and a ministére de l’enseignement supérieur, de la recherche et de
l’innovation (MESRI) doctoral thesis grant to M.D.
article_number: e02146-21
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
full_name: Windhaber, Stefan
last_name: Windhaber
- first_name: Qilin
full_name: Xin, Qilin
last_name: Xin
- first_name: Zina M.
full_name: Uckeley, Zina M.
last_name: Uckeley
- first_name: Jana
full_name: Koch, Jana
last_name: Koch
- first_name: Martin
full_name: Obr, Martin
id: 4741CA5A-F248-11E8-B48F-1D18A9856A87
last_name: Obr
- first_name: Céline
full_name: Garnier, Céline
last_name: Garnier
- first_name: Catherine
full_name: Luengo-Guyonnot, Catherine
last_name: Luengo-Guyonnot
- first_name: Maëva
full_name: Duboeuf, Maëva
last_name: Duboeuf
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
- first_name: Pierre-Yves
full_name: Lozach, Pierre-Yves
last_name: Lozach
citation:
ama: Windhaber S, Xin Q, Uckeley ZM, et al. The Orthobunyavirus Germiston enters
host cells from late endosomes. Journal of Virology. 2022;96(5). doi:10.1128/jvi.02146-21
apa: Windhaber, S., Xin, Q., Uckeley, Z. M., Koch, J., Obr, M., Garnier, C., … Lozach,
P.-Y. (2022). The Orthobunyavirus Germiston enters host cells from late endosomes.
Journal of Virology. American Society for Microbiology. https://doi.org/10.1128/jvi.02146-21
chicago: Windhaber, Stefan, Qilin Xin, Zina M. Uckeley, Jana Koch, Martin Obr, Céline
Garnier, Catherine Luengo-Guyonnot, Maëva Duboeuf, Florian KM Schur, and Pierre-Yves
Lozach. “The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes.”
Journal of Virology. American Society for Microbiology, 2022. https://doi.org/10.1128/jvi.02146-21.
ieee: S. Windhaber et al., “The Orthobunyavirus Germiston enters host cells
from late endosomes,” Journal of Virology, vol. 96, no. 5. American Society
for Microbiology, 2022.
ista: Windhaber S, Xin Q, Uckeley ZM, Koch J, Obr M, Garnier C, Luengo-Guyonnot
C, Duboeuf M, Schur FK, Lozach P-Y. 2022. The Orthobunyavirus Germiston enters
host cells from late endosomes. Journal of Virology. 96(5), e02146-21.
mla: Windhaber, Stefan, et al. “The Orthobunyavirus Germiston Enters Host Cells
from Late Endosomes.” Journal of Virology, vol. 96, no. 5, e02146-21, American
Society for Microbiology, 2022, doi:10.1128/jvi.02146-21.
short: S. Windhaber, Q. Xin, Z.M. Uckeley, J. Koch, M. Obr, C. Garnier, C. Luengo-Guyonnot,
M. Duboeuf, F.K. Schur, P.-Y. Lozach, Journal of Virology 96 (2022).
date_created: 2022-01-18T10:04:18Z
date_published: 2022-03-01T00:00:00Z
date_updated: 2023-08-02T13:52:33Z
day: '01'
department:
- _id: FlSc
doi: 10.1128/jvi.02146-21
external_id:
isi:
- '000779305000033'
pmid:
- '35019710'
intvolume: ' 96'
isi: 1
issue: '5'
keyword:
- virology
- insect science
- immunology
- microbiology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906410
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26736D6A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31445
name: Structural conservation and diversity in retroviral capsid
publication: Journal of Virology
publication_identifier:
eissn:
- 1098-5514
issn:
- 0022-538X
publication_status: published
publisher: American Society for Microbiology
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Orthobunyavirus Germiston enters host cells from late endosomes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 96
year: '2022'
...
---
_id: '10642'
abstract:
- lang: eng
text: Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized
but otherwise arbitrary perturbations of weakly interacting quantum spin systems
with uniformly gapped on-site terms change the ground state of such a system only
locally, even if they close the spectral gap. We call this a strong version of
the local perturbations perturb locally (LPPL) principle which is known to hold
for much more general gapped systems, but only for perturbations that do not close
the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle
to Hamiltonians that have the appropriate structure of gapped on-site terms and
weak interactions only locally in some region of space. While our results are
technically corollaries to a theorem of Yarotsky, we expect that the paradigm
of systems with a locally gapped ground state that is completely insensitive to
the form of the Hamiltonian elsewhere extends to other situations and has important
physical consequences.
acknowledgement: J. H. acknowledges partial financial support by the ERC Advanced
Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for
very helpful comments and discussions and Jürg Fröhlich for references to the literature.
Open Access funding enabled and organized by Projekt DEAL.
article_number: '9'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
- first_name: Tom
full_name: Wessel, Tom
last_name: Wessel
citation:
ama: Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally
gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 2022;112(1). doi:10.1007/s11005-021-01494-y
apa: Henheik, S. J., Teufel, S., & Wessel, T. (2022). Local stability of ground
states in locally gapped and weakly interacting quantum spin systems. Letters
in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s11005-021-01494-y
chicago: Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of
Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.”
Letters in Mathematical Physics. Springer Nature, 2022. https://doi.org/10.1007/s11005-021-01494-y.
ieee: S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states
in locally gapped and weakly interacting quantum spin systems,” Letters in
Mathematical Physics, vol. 112, no. 1. Springer Nature, 2022.
ista: Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in
locally gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 112(1), 9.
mla: Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped
and Weakly Interacting Quantum Spin Systems.” Letters in Mathematical Physics,
vol. 112, no. 1, 9, Springer Nature, 2022, doi:10.1007/s11005-021-01494-y.
short: S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022).
date_created: 2022-01-18T16:18:25Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:57:02Z
day: '18'
ddc:
- '530'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1007/s11005-021-01494-y
ec_funded: 1
external_id:
arxiv:
- '2106.13780'
isi:
- '000744930400001'
file:
- access_level: open_access
checksum: 7e8e69b76e892c305071a4736131fe18
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:41:14Z
date_updated: 2022-01-19T09:41:14Z
file_id: '10647'
file_name: 2022_LettersMathPhys_Henheik.pdf
file_size: 357547
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:41:14Z
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '1'
keyword:
- mathematical physics
- statistical and nonlinear physics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Letters in Mathematical Physics
publication_identifier:
eissn:
- 1573-0530
issn:
- 0377-9017
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Local stability of ground states in locally gapped and weakly interacting quantum
spin systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 112
year: '2022'
...
---
_id: '10643'
abstract:
- lang: eng
text: "We prove a generalised super-adiabatic theorem for extended fermionic systems
assuming a spectral gap only in the bulk. More precisely, we assume that the infinite
system has a unique ground state and that the corresponding Gelfand–Naimark–Segal
Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that
a similar adiabatic theorem also holds in the bulk of finite systems up to errors
that vanish faster than any inverse power of the system size, although the corresponding
finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n"
acknowledgement: J.H. acknowledges partial financial support by the ERC Advanced Grant
‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft
and the Open Access Publishing Fund of the University of Tübingen is gratefully
acknowledged.
article_number: e4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
citation:
ama: 'Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems
with a gap in the bulk. Forum of Mathematics, Sigma. 2022;10. doi:10.1017/fms.2021.80'
apa: 'Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic
limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. Cambridge
University Press. https://doi.org/10.1017/fms.2021.80'
chicago: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma. Cambridge
University Press, 2022. https://doi.org/10.1017/fms.2021.80.'
ieee: 'S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk,” Forum of Mathematics, Sigma, vol. 10.
Cambridge University Press, 2022.'
ista: 'Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.'
mla: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma, vol.
10, e4, Cambridge University Press, 2022, doi:10.1017/fms.2021.80.'
short: S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).
date_created: 2022-01-18T16:18:51Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:53:11Z
day: '18'
ddc:
- '510'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1017/fms.2021.80
ec_funded: 1
external_id:
arxiv:
- '2012.15239'
isi:
- '000743615000001'
file:
- access_level: open_access
checksum: 87592a755adcef22ea590a99dc728dd3
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:27:43Z
date_updated: 2022-01-19T09:27:43Z
file_id: '10646'
file_name: 2022_ForumMathSigma_Henheik.pdf
file_size: 705323
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:27:43Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- computational mathematics
- discrete mathematics and combinatorics
- geometry and topology
- mathematical physics
- statistics and probability
- algebra and number theory
- theoretical computer science
- analysis
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
eissn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: 'Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2022'
...
---
_id: '10652'
abstract:
- lang: eng
text: Finding a feasible scheme for testing the quantum mechanical nature of the
gravitational interaction has been attracting an increasing level of attention.
Gravity mediated entanglement generation so far appears to be the key ingredient
for a potential experiment. In a recent proposal [D. Carney et al., PRX Quantum
2, 030330 (2021)] combining an atom interferometer with a low-frequency mechanical
oscillator, a coherence revival test is proposed for verifying this entanglement
generation. With measurements performed only on the atoms, this protocol bypasses
the need for correlation measurements. Here, we explore formulations of such a
protocol, and specifically find that in the envisioned regime of operation with
high thermal excitation, semiclassical models, where there is no concept of entanglement,
also give the same experimental signatures. We elucidate in a fully quantum mechanical
calculation that entanglement is not the source of the revivals in the relevant
parameter regime. We argue that, in its current form, the suggested test is only
relevant if the oscillator is nearly in a pure quantum state, and in this regime
the effects are too small to be measurable. We further discuss potential open
ends. The results highlight the importance and subtleties of explicitly considering
how the quantum case differs from the classical expectations when testing for
the quantum mechanical nature of a physical system.
acknowledgement: O.H. is supported by Institute of Science and Technology Austria.
The author thanks Jess Riedel for discussions.
article_number: '013023'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
citation:
ama: Hosten O. Constraints on probing quantum coherence to infer gravitational entanglement.
Physical Review Research. 2022;4(1). doi:10.1103/PhysRevResearch.4.013023
apa: Hosten, O. (2022). Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. American Physical Society. https://doi.org/10.1103/PhysRevResearch.4.013023
chicago: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research. American Physical Society, 2022.
https://doi.org/10.1103/PhysRevResearch.4.013023.
ieee: O. Hosten, “Constraints on probing quantum coherence to infer gravitational
entanglement,” Physical Review Research, vol. 4, no. 1. American Physical
Society, 2022.
ista: Hosten O. 2022. Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. 4(1), 013023.
mla: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research, vol. 4, no. 1, 013023, American
Physical Society, 2022, doi:10.1103/PhysRevResearch.4.013023.
short: O. Hosten, Physical Review Research 4 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-10T00:00:00Z
date_updated: 2022-05-16T11:21:38Z
day: '10'
ddc:
- '530'
department:
- _id: OnHo
doi: 10.1103/PhysRevResearch.4.013023
file:
- access_level: open_access
checksum: 7254d267a0633ca5d63131d345e58686
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T11:12:44Z
date_updated: 2022-01-24T11:12:44Z
file_id: '10660'
file_name: 2022_PhysRevResearch_Hosten.pdf
file_size: 236329
relation: main_file
success: 1
file_date_updated: 2022-01-24T11:12:44Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Constraints on probing quantum coherence to infer gravitational entanglement
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '10653'
abstract:
- lang: eng
text: Squall lines are known to be the consequence of the interaction of low-level
shear with cold pools associated with convective downdrafts. Also, as the magnitude
of the shear increases beyond a critical shear, squall lines tend to orient themselves.
The existing literature suggests that this orientation reduces incoming wind shear
to the squall line, and maintains equilibrium between wind shear and cold pool
spreading. Although this theory is widely accepted, very few quantitative studies
have been conducted on supercritical regime especially. Here, we test this hypothesis
with tropical squall lines obtained by imposing a vertical wind shear in cloud
resolving simulations in radiative convective equilibrium. In the sub-critical
regime, squall lines are perpendicular to the shear. In the super-critical regime,
their orientation maintain the equilibrium, supporting existing theories. We also
find that as shear increases, cold pools become more intense. However, this intensification
has little impact on squall line orientation.
acknowledgement: The authors gratefully acknowledge funding from the European Research
Council (ERC) under the European Union's Horizon 2020 research and innovation program
(Project CLUSTER, Grant Agreement No. 805041), and from the PhD fellowship of Ecole
Normale Supérieure de Paris-Saclay. Two supplementary movies are also provided showing
the angle detection method and the squall line of the Usfc = 10 m s−1 simulation.
article_number: e2021GL095184
article_processing_charge: No
article_type: original
author:
- first_name: Sophie
full_name: Abramian, Sophie
last_name: Abramian
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Camille
full_name: Risi, Camille
last_name: Risi
citation:
ama: Abramian S, Muller CJ, Risi C. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 2022;49(1). doi:10.1029/2021GL095184
apa: Abramian, S., Muller, C. J., & Risi, C. (2022). Shear-convection interactions
and orientation of tropical squall lines. Geophysical Research Letters.
Wiley. https://doi.org/10.1029/2021GL095184
chicago: Abramian, Sophie, Caroline J Muller, and Camille Risi. “Shear-Convection
Interactions and Orientation of Tropical Squall Lines.” Geophysical Research
Letters. Wiley, 2022. https://doi.org/10.1029/2021GL095184.
ieee: S. Abramian, C. J. Muller, and C. Risi, “Shear-convection interactions and
orientation of tropical squall lines,” Geophysical Research Letters, vol.
49, no. 1. Wiley, 2022.
ista: Abramian S, Muller CJ, Risi C. 2022. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 49(1), e2021GL095184.
mla: Abramian, Sophie, et al. “Shear-Convection Interactions and Orientation of
Tropical Squall Lines.” Geophysical Research Letters, vol. 49, no. 1, e2021GL095184,
Wiley, 2022, doi:10.1029/2021GL095184.
short: S. Abramian, C.J. Muller, C. Risi, Geophysical Research Letters 49 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-16T00:00:00Z
date_updated: 2023-08-02T14:00:17Z
day: '16'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2021GL095184
ec_funded: 1
external_id:
isi:
- '000743989800040'
file:
- access_level: open_access
checksum: 08f88b57b8e409b42e382452cd5f297b
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T12:14:41Z
date_updated: 2022-01-24T12:14:41Z
file_id: '10662'
file_name: 2022_GeophysResearchLet_Abramian.pdf
file_size: 1117408
relation: main_file
success: 1
file_date_updated: 2022-01-24T12:14:41Z
has_accepted_license: '1'
intvolume: ' 49'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Geophysical Research Letters
publication_identifier:
eissn:
- 1944-8007
issn:
- 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1002/essoar.10507697.1
scopus_import: '1'
status: public
title: Shear-convection interactions and orientation of tropical squall lines
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 49
year: '2022'
...
---
_id: '10654'
abstract:
- lang: eng
text: "Directed percolation (DP) has recently emerged as a possible solution to
the century old puzzle surrounding the transition to turbulence. Multiple model
studies reported DP exponents, however, experimental evidence is limited since
the largest possible observation times are orders of magnitude shorter than the
flows’ characteristic timescales. An exception is cylindrical Couette flow where
the limit is not temporal, but rather the realizable system size. We present experiments
in a Couette setup of unprecedented azimuthal and axial aspect ratios. Approaching
the critical point to within less than 0.1% we determine five critical exponents,
all of which are in excellent agreement with the 2+1D DP universality class. The
complex dynamics encountered at \r\nthe onset of turbulence can hence be fully
rationalized within the framework of statistical mechanics."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: "We thank T.Menner, T.Asenov, P. Maier and the Miba machine shop
of IST Austria for their valuable support in all technical aspects. We thank Marc
Avila for comments on the manuscript. This work was supported by a grant from the
Simons Foundation (662960, B.H.). We acknowledge the European Research Council under
the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement
306589 for financial support. K.A.\r\nacknowledges funding from the Central Research
Development Fund of the University of Bremen, grant number ZF04B /2019/FB04 Avila
Kerstin (”Independent Project for Postdocs”). L.K. was supported by the European
Union’s Horizon 2020 Research and innovation programme under the Marie Sklodowska-Curie
grant agreement No. 754411.\r\n"
article_number: '014502'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Lukasz
full_name: Klotz, Lukasz
id: 2C9AF1C2-F248-11E8-B48F-1D18A9856A87
last_name: Klotz
orcid: 0000-0003-1740-7635
- first_name: Grégoire M
full_name: Lemoult, Grégoire M
id: 4787FE80-F248-11E8-B48F-1D18A9856A87
last_name: Lemoult
- first_name: Kerstin
full_name: Avila, Kerstin
last_name: Avila
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Klotz L, Lemoult GM, Avila K, Hof B. Phase transition to turbulence in spatially
extended shear flows. Physical Review Letters. 2022;128(1). doi:10.1103/PhysRevLett.128.014502
apa: Klotz, L., Lemoult, G. M., Avila, K., & Hof, B. (2022). Phase transition
to turbulence in spatially extended shear flows. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/PhysRevLett.128.014502
chicago: Klotz, Lukasz, Grégoire M Lemoult, Kerstin Avila, and Björn Hof. “Phase
Transition to Turbulence in Spatially Extended Shear Flows.” Physical Review
Letters. American Physical Society, 2022. https://doi.org/10.1103/PhysRevLett.128.014502.
ieee: L. Klotz, G. M. Lemoult, K. Avila, and B. Hof, “Phase transition to turbulence
in spatially extended shear flows,” Physical Review Letters, vol. 128,
no. 1. American Physical Society, 2022.
ista: Klotz L, Lemoult GM, Avila K, Hof B. 2022. Phase transition to turbulence
in spatially extended shear flows. Physical Review Letters. 128(1), 014502.
mla: Klotz, Lukasz, et al. “Phase Transition to Turbulence in Spatially Extended
Shear Flows.” Physical Review Letters, vol. 128, no. 1, 014502, American
Physical Society, 2022, doi:10.1103/PhysRevLett.128.014502.
short: L. Klotz, G.M. Lemoult, K. Avila, B. Hof, Physical Review Letters 128 (2022).
date_created: 2022-01-23T23:01:28Z
date_published: 2022-01-05T00:00:00Z
date_updated: 2023-08-02T13:59:19Z
day: '05'
department:
- _id: BjHo
doi: 10.1103/PhysRevLett.128.014502
ec_funded: 1
external_id:
arxiv:
- '2111.14894'
isi:
- '000748271700010'
pmid:
- '35061458'
intvolume: ' 128'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2111.14894
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: 'Revisiting the Turbulence Problem Using Statistical Mechanics: Experimental
Studies on Transitional and Turbulent Flows'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase transition to turbulence in spatially extended shear flows
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 128
year: '2022'
...
---
_id: '10656'
abstract:
- lang: eng
text: Idealized simulations of the tropical atmosphere have predicted that clouds
can spontaneously clump together in space, despite perfectly homogeneous settings.
This phenomenon has been called self-aggregation, and it results in a state where
a moist cloudy region with intense deep convective storms is surrounded by extremely
dry subsiding air devoid of deep clouds. We review here the main findings from
theoretical work and idealized models of this phenomenon, highlighting the physical
processes believed to play a key role in convective self-aggregation. We also
review the growing literature on the importance and implications of this phenomenon
for the tropical atmosphere, notably, for the hydrological cycle and for precipitation
extremes, in our current and in a warming climate.
acknowledgement: C.M. gratefully acknowledges funding from the European Research Council
(ERC) under the European Union's Horizon 2020 research and innovation program (Project
CLUSTER, grant agreement 805041). She also thanks Grand Équipement National de Calcul
Intensif (GENCI), France, for providing access to their computing platforms at Très
Grand Centre de Calcul (TGCC). J.O.H. gratefully acknowledges funding from the Villum
Foundation (grant 13168), the ERC under the Horizon 2020 research and innovation
program (grant 771859), and the Novo Nordisk Foundation's Interdisciplinary Synergy
Program (grant NNF19OC0057374). G.C. gratefully acknowledges the support of the
transregional collaborative research center (SFB/TRR 165) “Waves to Weather” (http://www.wavestoweather.de)
funded by the German Research Foundation (DFG). D.Y. is supported by a Packard Fellowship
in Science and Engineering, the France–Berkeley Fund, Laboratory Directed Research
and Development (LDRD) funding from the Lawrence Berkeley National Laboratory, and
the US Department of Energy, Office of Science, Office of Biological and Environmental
Research, Climate and Environmental Sciences Division, Regional and Global Climate
Modeling Program under award DE-AC02-05CH11231.
article_processing_charge: No
article_type: original
author:
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Da
full_name: Yang, Da
last_name: Yang
- first_name: George
full_name: Craig, George
last_name: Craig
- first_name: Timothy
full_name: Cronin, Timothy
last_name: Cronin
- first_name: Benjamin
full_name: Fildier, Benjamin
last_name: Fildier
- first_name: Jan O.
full_name: Haerter, Jan O.
last_name: Haerter
- first_name: Cathy
full_name: Hohenegger, Cathy
last_name: Hohenegger
- first_name: Brian
full_name: Mapes, Brian
last_name: Mapes
- first_name: David
full_name: Randall, David
last_name: Randall
- first_name: Sara
full_name: Shamekh, Sara
last_name: Shamekh
- first_name: Steven C.
full_name: Sherwood, Steven C.
last_name: Sherwood
citation:
ama: Muller CJ, Yang D, Craig G, et al. Spontaneous aggregation of convective storms.
Annual Review of Fluid Mechanics. 2022;54:133-157. doi:10.1146/annurev-fluid-022421-011319
apa: Muller, C. J., Yang, D., Craig, G., Cronin, T., Fildier, B., Haerter, J. O.,
… Sherwood, S. C. (2022). Spontaneous aggregation of convective storms. Annual
Review of Fluid Mechanics. Annual Reviews. https://doi.org/10.1146/annurev-fluid-022421-011319
chicago: Muller, Caroline J, Da Yang, George Craig, Timothy Cronin, Benjamin Fildier,
Jan O. Haerter, Cathy Hohenegger, et al. “Spontaneous Aggregation of Convective
Storms.” Annual Review of Fluid Mechanics. Annual Reviews, 2022. https://doi.org/10.1146/annurev-fluid-022421-011319.
ieee: C. J. Muller et al., “Spontaneous aggregation of convective storms,”
Annual Review of Fluid Mechanics, vol. 54. Annual Reviews, pp. 133–157,
2022.
ista: Muller CJ, Yang D, Craig G, Cronin T, Fildier B, Haerter JO, Hohenegger C,
Mapes B, Randall D, Shamekh S, Sherwood SC. 2022. Spontaneous aggregation of convective
storms. Annual Review of Fluid Mechanics. 54, 133–157.
mla: Muller, Caroline J., et al. “Spontaneous Aggregation of Convective Storms.”
Annual Review of Fluid Mechanics, vol. 54, Annual Reviews, 2022, pp. 133–57,
doi:10.1146/annurev-fluid-022421-011319.
short: C.J. Muller, D. Yang, G. Craig, T. Cronin, B. Fildier, J.O. Haerter, C. Hohenegger,
B. Mapes, D. Randall, S. Shamekh, S.C. Sherwood, Annual Review of Fluid Mechanics
54 (2022) 133–157.
date_created: 2022-01-23T23:01:29Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2023-10-03T10:51:07Z
day: '01'
department:
- _id: CaMu
doi: 10.1146/annurev-fluid-022421-011319
ec_funded: 1
external_id:
isi:
- '000794152800006'
intvolume: ' 54'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1146/annurev-fluid-022421-011319
month: '01'
oa: 1
oa_version: Published Version
page: 133-157
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Annual Review of Fluid Mechanics
publication_identifier:
eissn:
- 1545-4479
issn:
- 0066-4189
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spontaneous aggregation of convective storms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2022'
...
---
_id: '10658'
abstract:
- lang: eng
text: We analyse how migration from a large mainland influences genetic load and
population numbers on an island, in a scenario where fitness-affecting variants
are unconditionally deleterious, and where numbers decline with increasing load.
Our analysis shows that migration can have qualitatively different effects, depending
on the total mutation target and fitness effects of deleterious variants. In particular,
we find that populations exhibit a genetic Allee effect across a wide range of
parameter combinations, when variants are partially recessive, cycling between
low-load (large-population) and high-load (sink) states. Increased migration reduces
load in the sink state (by increasing heterozygosity) but further inflates load
in the large-population state (by hindering purging). We identify various critical
parameter thresholds at which one or other stable state collapses, and discuss
how these thresholds are influenced by the genetic versus demographic effects
of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which
accounts for genetic drift but neglects demographic stochasticity. We also compare
against simulations which account for both demographic stochasticity and drift.
Our results clarify the importance of gene flow as a key determinant of extinction
risk in peripheral populations, even in the absence of ecological gradients. This
article is part of the theme issue ‘Species’ ranges in the face of changing environments
(part I)’.
acknowledgement: This research was partly funded by the Austrian Science Fund (FWF)
(grant no. P-32896B).
article_number: '20210010'
article_processing_charge: No
article_type: original
author:
- first_name: Himani
full_name: Sachdeva, Himani
last_name: Sachdeva
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral
populations: The roles of migration, drift and demographic stochasticity. Philosophical
Transactions of the Royal Society B. 2022;377(1846). doi:10.1098/rstb.2021.0010'
apa: 'Sachdeva, H., Olusanya, O. O., & Barton, N. H. (2022). Genetic load and
extinction in peripheral populations: The roles of migration, drift and demographic
stochasticity. Philosophical Transactions of the Royal Society B. The Royal
Society. https://doi.org/10.1098/rstb.2021.0010'
chicago: 'Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic
Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and
Demographic Stochasticity.” Philosophical Transactions of the Royal Society
B. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0010.'
ieee: 'H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction
in peripheral populations: The roles of migration, drift and demographic stochasticity,”
Philosophical Transactions of the Royal Society B, vol. 377, no. 1846.
The Royal Society, 2022.'
ista: 'Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in
peripheral populations: The roles of migration, drift and demographic stochasticity.
Philosophical Transactions of the Royal Society B. 377(1846), 20210010.'
mla: 'Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations:
The Roles of Migration, Drift and Demographic Stochasticity.” Philosophical
Transactions of the Royal Society B, vol. 377, no. 1846, 20210010, The Royal
Society, 2022, doi:10.1098/rstb.2021.0010.'
short: H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the
Royal Society B 377 (2022).
date_created: 2022-01-24T10:34:53Z
date_published: 2022-01-24T00:00:00Z
date_updated: 2025-05-26T09:05:09Z
day: '24'
ddc:
- '576'
department:
- _id: GradSch
- _id: NiBa
doi: 10.1098/rstb.2021.0010
external_id:
isi:
- '000745854300008'
pmid:
- '35067097'
file:
- access_level: open_access
checksum: 04ca9e2f0e344d680b947f2457df8d0a
content_type: application/pdf
creator: oolusany
date_created: 2022-01-24T10:34:45Z
date_updated: 2022-01-24T10:34:45Z
file_id: '10659'
file_name: rstb.2021.0010.pdf
file_size: 1845792
relation: main_file
file_date_updated: 2022-01-24T10:34:45Z
has_accepted_license: '1'
intvolume: ' 377'
isi: 1
issue: '1846'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
publication: Philosophical Transactions of the Royal Society B
publication_identifier:
eissn:
- 1471-2970
issn:
- 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1101/2021.08.05.455207
record:
- id: '14711'
relation: dissertation_contains
status: public
status: public
title: 'Genetic load and extinction in peripheral populations: The roles of migration,
drift and demographic stochasticity'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 377
year: '2022'
...
---
_id: '10702'
abstract:
- lang: eng
text: 'Background: Blood-based markers of cognitive functioning might provide an
accessible way to track neurodegeneration years prior to clinical manifestation
of cognitive impairment and dementia. Results: Using blood-based epigenome-wide
analyses of general cognitive function, we show that individual differences in
DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function
(g). A DNAm predictor explains ~4% of the variance, independently of a polygenic
score, in two external cohorts. It also associates with circulating levels of
neurology- and inflammation-related proteins, global brain imaging metrics, and
regional cortical volumes. Conclusions: As sample sizes increase, the ability
to assess cognitive function from DNAm data may be informative in settings where
cognitive testing is unreliable or unavailable.'
acknowledgement: 'GS received core support from the Chief Scientist Office of the
Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council
(HR03006). Genotyping and DNA methylation profiling of the GS samples was carried
out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility,
Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome
Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally
(STRADL; Reference 104036/Z/14/Z). The DNA methylation data assayed for Generation
Scotland was partially funded by a 2018 NARSAD Young Investigator Grant from the
Brain & Behavior Research Foundation (Ref: 27404; awardee: Dr David M Howard) and
by a JMAS SIM fellowship from the Royal College of Physicians of Edinburgh (Awardee:
Dr Heather C Whalley). LBC1936 MRI brain imaging was supported by Medical Research
Council (MRC) grants [G0701120], [G1001245], [MR/M013111/1] and [MR/R024065/1].
Magnetic resonance image acquisition and analyses were conducted at the Brain Research
Imaging Centre, Neuroimaging Sciences, University of Edinburgh (www.bric.ed.ac.uk)
which is part of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)
collaboration (www.sinapse.ac.uk) funded by the Scottish Funding Council and the
Chief Scientist Office. This work was supported by the European Union Horizon 2020
(PHC.03.15, project No 666881), SVDs@Target, the Fondation Leducq Transatlantic
Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease
[ref no. 16 CVD 05]. We thank the LBC1936 participants and team members who contributed
to these studies. The LBC1936 is supported by Age UK (Disconnected Mind project,
which supports S.E.H.), the Medical Research Council (G0701120, G1001245, MR/M013111/1,
MR/R024065/1) and the University of Edinburgh. Methylation typing of LBC1936 was
supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund
award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University
of Edinburgh, and The University of Queensland. Genotyping was funded by the Biotechnology
and Biological Sciences Research Council (BB/F019394/1). Proteomic analyses in LBC1936
were supported by the Age UK grant and NIH Grants R01AG054628 and R01AG05462802S1.
M.V.H. is funded by the Row Fogo Charitable Trust (Grant no. BROD.FID3668413). J.M.W
is supported by the UK Dementia Research Institute which receives its funding from
DRI Ltd, funded by the UK Medical Research Council, Alzheimers Society and Alzheimers
Research UK. R.F.H., E.L.S.C and D.A.G. are supported by funding from the Wellcome
Trust 4 year PhD in Translational Neuroscience: training the next generation of
basic neuroscientists to embrace clinical research [108890/Z/15/Z]. E.M.T.D. was
supported by the National Institutes of Health (NIH) grants R01AG054628, R01MH120219,
R01HD083613, P2CHD042849 and P30AG066614. S.R.C. was also supported by a National
Institutes of Health (NIH) research grant R01AG054628 and is supported by a Sir
Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society
(Grant Number 221890/Z/20/Z). D.L.Mc.C. and R.E.M. are supported by Alzheimers Research
UK major project grant ARUK/PG2017B/10. R.E.M. is supported by Alzheimer’s Society
major project grant AS-PG-19b-010. This research was funded in whole, or in part,
by Wellcome [104036/Z/14/Z and 108890/Z/15/Z]. For the purpose of open access, the
author has applied a CC BY public copyright licence to any Author Accepted Manuscript
version arising from this submission.'
article_number: '26'
article_processing_charge: No
article_type: original
author:
- first_name: Daniel L.
full_name: McCartney, Daniel L.
last_name: McCartney
- first_name: Robert F.
full_name: Hillary, Robert F.
last_name: Hillary
- first_name: Eleanor L.S.
full_name: Conole, Eleanor L.S.
last_name: Conole
- first_name: Daniel Trejo
full_name: Banos, Daniel Trejo
last_name: Banos
- first_name: Danni A.
full_name: Gadd, Danni A.
last_name: Gadd
- first_name: Rosie M.
full_name: Walker, Rosie M.
last_name: Walker
- first_name: Cliff
full_name: Nangle, Cliff
last_name: Nangle
- first_name: Robin
full_name: Flaig, Robin
last_name: Flaig
- first_name: Archie
full_name: Campbell, Archie
last_name: Campbell
- first_name: Alison D.
full_name: Murray, Alison D.
last_name: Murray
- first_name: Susana Muñoz
full_name: Maniega, Susana Muñoz
last_name: Maniega
- first_name: María Del C.
full_name: Valdés-Hernández, María Del C.
last_name: Valdés-Hernández
- first_name: Mathew A.
full_name: Harris, Mathew A.
last_name: Harris
- first_name: Mark E.
full_name: Bastin, Mark E.
last_name: Bastin
- first_name: Joanna M.
full_name: Wardlaw, Joanna M.
last_name: Wardlaw
- first_name: Sarah E.
full_name: Harris, Sarah E.
last_name: Harris
- first_name: David J.
full_name: Porteous, David J.
last_name: Porteous
- first_name: Elliot M.
full_name: Tucker-Drob, Elliot M.
last_name: Tucker-Drob
- first_name: Andrew M.
full_name: McIntosh, Andrew M.
last_name: McIntosh
- first_name: Kathryn L.
full_name: Evans, Kathryn L.
last_name: Evans
- first_name: Ian J.
full_name: Deary, Ian J.
last_name: Deary
- first_name: Simon R.
full_name: Cox, Simon R.
last_name: Cox
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Riccardo E.
full_name: Marioni, Riccardo E.
last_name: Marioni
citation:
ama: McCartney DL, Hillary RF, Conole ELS, et al. Blood-based epigenome-wide analyses
of cognitive abilities. Genome Biology. 2022;23(1). doi:10.1186/s13059-021-02596-5
apa: McCartney, D. L., Hillary, R. F., Conole, E. L. S., Banos, D. T., Gadd, D.
A., Walker, R. M., … Marioni, R. E. (2022). Blood-based epigenome-wide analyses
of cognitive abilities. Genome Biology. Springer Nature. https://doi.org/10.1186/s13059-021-02596-5
chicago: McCartney, Daniel L., Robert F. Hillary, Eleanor L.S. Conole, Daniel Trejo
Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, et al. “Blood-Based Epigenome-Wide
Analyses of Cognitive Abilities.” Genome Biology. Springer Nature, 2022.
https://doi.org/10.1186/s13059-021-02596-5.
ieee: D. L. McCartney et al., “Blood-based epigenome-wide analyses of cognitive
abilities,” Genome Biology, vol. 23, no. 1. Springer Nature, 2022.
ista: McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle
C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA,
Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans
KL, Deary IJ, Cox SR, Robinson MR, Marioni RE. 2022. Blood-based epigenome-wide
analyses of cognitive abilities. Genome Biology. 23(1), 26.
mla: McCartney, Daniel L., et al. “Blood-Based Epigenome-Wide Analyses of Cognitive
Abilities.” Genome Biology, vol. 23, no. 1, 26, Springer Nature, 2022,
doi:10.1186/s13059-021-02596-5.
short: D.L. McCartney, R.F. Hillary, E.L.S. Conole, D.T. Banos, D.A. Gadd, R.M.
Walker, C. Nangle, R. Flaig, A. Campbell, A.D. Murray, S.M. Maniega, M.D.C. Valdés-Hernández,
M.A. Harris, M.E. Bastin, J.M. Wardlaw, S.E. Harris, D.J. Porteous, E.M. Tucker-Drob,
A.M. McIntosh, K.L. Evans, I.J. Deary, S.R. Cox, M.R. Robinson, R.E. Marioni,
Genome Biology 23 (2022).
date_created: 2022-01-30T23:01:33Z
date_published: 2022-01-17T00:00:00Z
date_updated: 2023-08-02T14:05:13Z
day: '17'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1186/s13059-021-02596-5
external_id:
isi:
- '000744358300002'
file:
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checksum: 34f10bb2b0594189dcac24d13b691d52
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-31T13:16:05Z
date_updated: 2022-01-31T13:16:05Z
file_id: '10708'
file_name: 2022_GenomeBio_McCartney.pdf
file_size: 1540606
relation: main_file
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month: '01'
oa: 1
oa_version: Published Version
project:
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grant_number: PCEGP3_181181
name: Improving estimation and prediction of common complex disease risk
publication: Genome Biology
publication_identifier:
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publisher: Springer Nature
quality_controlled: '1'
related_material:
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url: https://doi.org/10.1101/2021.05.24.21257698
record:
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status: public
scopus_import: '1'
status: public
title: Blood-based epigenome-wide analyses of cognitive abilities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2022'
...
---
_id: '10703'
abstract:
- lang: eng
text: 'When crawling through the body, leukocytes often traverse tissues that are
densely packed with extracellular matrix and other cells, and this raises the
question: How do leukocytes overcome compressive mechanical loads? Here, we show
that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness
requires neither force sensing via the nucleus nor adhesive interactions with
a substrate. Upon global compression of the cell body as well as local indentation
of the plasma membrane, Wiskott-Aldrich syndrome protein (WASp) assembles into
dot-like structures, providing activation platforms for Arp2/3 nucleated actin
patches. These patches locally push against the external load, which can be obstructing
collagen fibers or other cells, and thereby create space to facilitate forward
locomotion. We show in vitro and in vivo that this WASp function is rate limiting
for ameboid leukocyte migration in dense but not in loose environments and is
required for trafficking through diverse tissues such as skin and lymph nodes.'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: We thank N. Darwish-Miranda, F. Leite, F.P. Assen, and A. Eichner
for advice and help with experiments. We thank J. Renkawitz, E. Kiermaier, A. Juanes
Garcia, and M. Avellaneda for critical reading of the manuscript. We thank M. Driscoll
for advice on fluorescent labeling of collagen gels. This research was supported
by the Scientific Service Units (SSUs) of IST Austria through resources provided
by Molecular Biology Services/Lab Support Facility (LSF)/Bioimaging Facility/Electron
Microscopy Facility. This work was funded by grants from the European Research Council
( CoG 724373 ) and the Austrian Science Foundation (FWF) to M.S. F.G. received funding
from the European Union’s Horizon 2020 research and innovation program under the
Marie Skłodowska-Curie grant agreement no. 747687.
article_processing_charge: No
article_type: original
author:
- first_name: Florian
full_name: Gaertner, Florian
last_name: Gaertner
- first_name: Patricia
full_name: Reis-Rodrigues, Patricia
last_name: Reis-Rodrigues
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Juan
full_name: Aguilera, Juan
last_name: Aguilera
- first_name: Michael
full_name: Riedl, Michael
id: 3BE60946-F248-11E8-B48F-1D18A9856A87
last_name: Riedl
orcid: 0000-0003-4844-6311
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
orcid: 0000-0002-1073-744X
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Aglaja
full_name: Kopf, Aglaja
id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
last_name: Kopf
orcid: 0000-0002-2187-6656
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Vanessa
full_name: Zheden, Vanessa
id: 39C5A68A-F248-11E8-B48F-1D18A9856A87
last_name: Zheden
orcid: 0000-0002-9438-4783
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Gaertner F, Reis-Rodrigues P, de Vries I, et al. WASp triggers mechanosensitive
actin patches to facilitate immune cell migration in dense tissues. Developmental
Cell. 2022;57(1):47-62.e9. doi:10.1016/j.devcel.2021.11.024
apa: Gaertner, F., Reis-Rodrigues, P., de Vries, I., Hons, M., Aguilera, J., Riedl,
M., … Sixt, M. K. (2022). WASp triggers mechanosensitive actin patches to facilitate
immune cell migration in dense tissues. Developmental Cell. Cell Press ;
Elsevier. https://doi.org/10.1016/j.devcel.2021.11.024
chicago: Gaertner, Florian, Patricia Reis-Rodrigues, Ingrid de Vries, Miroslav Hons,
Juan Aguilera, Michael Riedl, Alexander F Leithner, et al. “WASp Triggers Mechanosensitive
Actin Patches to Facilitate Immune Cell Migration in Dense Tissues.” Developmental
Cell. Cell Press ; Elsevier, 2022. https://doi.org/10.1016/j.devcel.2021.11.024.
ieee: F. Gaertner et al., “WASp triggers mechanosensitive actin patches to
facilitate immune cell migration in dense tissues,” Developmental Cell,
vol. 57, no. 1. Cell Press ; Elsevier, p. 47–62.e9, 2022.
ista: Gaertner F, Reis-Rodrigues P, de Vries I, Hons M, Aguilera J, Riedl M, Leithner
AF, Tasciyan S, Kopf A, Merrin J, Zheden V, Kaufmann W, Hauschild R, Sixt MK.
2022. WASp triggers mechanosensitive actin patches to facilitate immune cell migration
in dense tissues. Developmental Cell. 57(1), 47–62.e9.
mla: Gaertner, Florian, et al. “WASp Triggers Mechanosensitive Actin Patches to
Facilitate Immune Cell Migration in Dense Tissues.” Developmental Cell,
vol. 57, no. 1, Cell Press ; Elsevier, 2022, p. 47–62.e9, doi:10.1016/j.devcel.2021.11.024.
short: F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl,
A.F. Leithner, S. Tasciyan, A. Kopf, J. Merrin, V. Zheden, W. Kaufmann, R. Hauschild,
M.K. Sixt, Developmental Cell 57 (2022) 47–62.e9.
date_created: 2022-01-30T23:01:33Z
date_published: 2022-01-10T00:00:00Z
date_updated: 2024-03-25T23:30:12Z
day: '10'
ddc:
- '570'
department:
- _id: MiSi
- _id: EM-Fac
- _id: NanoFab
- _id: BjHo
doi: 10.1016/j.devcel.2021.11.024
ec_funded: 1
external_id:
isi:
- '000768933800005'
pmid:
- '34919802'
intvolume: ' 57'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S1534580721009497
month: '01'
oa: 1
oa_version: Published Version
page: 47-62.e9
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
publication: Developmental Cell
publication_identifier:
eissn:
- 1878-1551
issn:
- 1534-5807
publication_status: published
publisher: Cell Press ; Elsevier
quality_controlled: '1'
related_material:
record:
- id: '12726'
relation: dissertation_contains
status: public
- id: '14530'
relation: dissertation_contains
status: public
- id: '12401'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: WASp triggers mechanosensitive actin patches to facilitate immune cell migration
in dense tissues
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 57
year: '2022'
...
---
_id: '10704'
abstract:
- lang: eng
text: We define and study the existence of very stable Higgs bundles on Riemann
surfaces, how it implies a precise formula for the multiplicity of the very stable
components of the global nilpotent cone and its relationship to mirror symmetry.
The main ingredients are the Bialynicki-Birula theory of C∗-actions on semiprojective
varieties, C∗ characters of indices of C∗-equivariant coherent sheaves, Hecke
transformation for Higgs bundles, relative Fourier–Mukai transform along the Hitchin
fibration, hyperholomorphic structures on universal bundles and cominuscule Higgs
bundles.
acknowledgement: We would like to thank Brian Collier, Davide Gaiotto, Peter Gothen,
Jochen Heinloth, Daniel Huybrechts, Quoc Ho, Joel Kamnitzer, Gérard Laumon, Luca
Migliorini, Alexander Minets, Brent Pym, Peng Shan, Carlos Simpson, András Szenes,
Fernando R. Villegas, Richard Wentworth, Edward Witten and Kōta Yoshioka for interesting
comments and discussions. Most of all we are grateful for a long list of very helpful
comments by the referee. We would also like to thank the organizers of the Summer
School on Higgs bundles in Hamburg in September 2018, where the authors and Richard
Wentworth were giving lectures and where the work in this paper started by considering
the mirror of the Lagrangian upward flows W+E investigated in [17]. The second author
wishes to thank EPSRC and ICMAT for support. Open access funding provided by Institute
of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Tamás
full_name: Hausel, Tamás
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Nigel
full_name: Hitchin, Nigel
last_name: Hitchin
citation:
ama: Hausel T, Hitchin N. Very stable Higgs bundles, equivariant multiplicity and
mirror symmetry. Inventiones Mathematicae. 2022;228:893-989. doi:10.1007/s00222-021-01093-7
apa: Hausel, T., & Hitchin, N. (2022). Very stable Higgs bundles, equivariant
multiplicity and mirror symmetry. Inventiones Mathematicae. Springer Nature.
https://doi.org/10.1007/s00222-021-01093-7
chicago: Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant
Multiplicity and Mirror Symmetry.” Inventiones Mathematicae. Springer Nature,
2022. https://doi.org/10.1007/s00222-021-01093-7.
ieee: T. Hausel and N. Hitchin, “Very stable Higgs bundles, equivariant multiplicity
and mirror symmetry,” Inventiones Mathematicae, vol. 228. Springer Nature,
pp. 893–989, 2022.
ista: Hausel T, Hitchin N. 2022. Very stable Higgs bundles, equivariant multiplicity
and mirror symmetry. Inventiones Mathematicae. 228, 893–989.
mla: Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant Multiplicity
and Mirror Symmetry.” Inventiones Mathematicae, vol. 228, Springer Nature,
2022, pp. 893–989, doi:10.1007/s00222-021-01093-7.
short: T. Hausel, N. Hitchin, Inventiones Mathematicae 228 (2022) 893–989.
date_created: 2022-01-30T23:01:34Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T14:03:20Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1007/s00222-021-01093-7
external_id:
arxiv:
- '2101.08583'
isi:
- '000745495400001'
file:
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checksum: a382ba75acebc9adfb8fe56247cb410e
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creator: dernst
date_created: 2023-02-27T07:30:47Z
date_updated: 2023-02-27T07:30:47Z
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file_date_updated: 2023-02-27T07:30:47Z
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language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 893-989
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Inventiones Mathematicae
publication_identifier:
eissn:
- 1432-1297
issn:
- 0020-9910
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on the ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/the-tip-of-the-mathematical-iceberg/
scopus_import: '1'
status: public
title: Very stable Higgs bundles, equivariant multiplicity and mirror symmetry
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 228
year: '2022'
...
---
_id: '10705'
abstract:
- lang: eng
text: Although rigidity and jamming transitions have been widely studied in physics
and material science, their importance in a number of biological processes, including
embryo development, tissue homeostasis, wound healing, and disease progression,
has only begun to be recognized in the past few years. The hypothesis that biological
systems can undergo rigidity/jamming transitions is attractive, as it would allow
these systems to change their material properties rapidly and strongly. However,
whether such transitions indeed occur in biological systems, how they are being
regulated, and what their physiological relevance might be, is still being debated.
Here, we review theoretical and experimental advances from the past few years,
focusing on the regulation and role of potential tissue rigidity transitions in
different biological processes.
acknowledgement: We thank present and former members of the Heisenberg and Hannezo
groups, in particular Bernat Corominas-Murtra and Nicoletta Petridou, for helpful
discussions, and Claudia Flandoli for the artwork. We apologize for not being able
to cite a number of highly relevant studies, to stay within the maximum allowed
number of citations.
article_processing_charge: No
article_type: original
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Hannezo EB, Heisenberg C-PJ. Rigidity transitions in development and disease.
Trends in Cell Biology. 2022;32(5):P433-444. doi:10.1016/j.tcb.2021.12.006
apa: Hannezo, E. B., & Heisenberg, C.-P. J. (2022). Rigidity transitions in
development and disease. Trends in Cell Biology. Cell Press. https://doi.org/10.1016/j.tcb.2021.12.006
chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Rigidity Transitions
in Development and Disease.” Trends in Cell Biology. Cell Press, 2022.
https://doi.org/10.1016/j.tcb.2021.12.006.
ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Rigidity transitions in development
and disease,” Trends in Cell Biology, vol. 32, no. 5. Cell Press, pp. P433-444,
2022.
ista: Hannezo EB, Heisenberg C-PJ. 2022. Rigidity transitions in development and
disease. Trends in Cell Biology. 32(5), P433-444.
mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Rigidity Transitions
in Development and Disease.” Trends in Cell Biology, vol. 32, no. 5, Cell
Press, 2022, pp. P433-444, doi:10.1016/j.tcb.2021.12.006.
short: E.B. Hannezo, C.-P.J. Heisenberg, Trends in Cell Biology 32 (2022) P433-444.
date_created: 2022-01-30T23:01:34Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T14:03:53Z
day: '01'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1016/j.tcb.2021.12.006
external_id:
isi:
- '000795773900009'
pmid:
- '35058104'
intvolume: ' 32'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: P433-444
pmid: 1
publication: Trends in Cell Biology
publication_identifier:
eissn:
- 1879-3088
issn:
- 0962-8924
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rigidity transitions in development and disease
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2022'
...
---
_id: '10706'
abstract:
- lang: eng
text: This is a collection of problems composed by some participants of the workshop
“Differential Geometry, Billiards, and Geometric Optics” that took place at CIRM
on October 4–8, 2021.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Misha
full_name: Bialy, Misha
last_name: Bialy
- first_name: Corentin
full_name: Fiorebe, Corentin
id: 06619f18-9070-11eb-847d-d1ee780bd88b
last_name: Fiorebe
- first_name: Alexey
full_name: Glutsyuk, Alexey
last_name: Glutsyuk
- first_name: Mark
full_name: Levi, Mark
last_name: Levi
- first_name: Alexander
full_name: Plakhov, Alexander
last_name: Plakhov
- first_name: Serge
full_name: Tabachnikov, Serge
last_name: Tabachnikov
citation:
ama: Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. Open problems
on billiards and geometric optics. Arnold Mathematical Journal. 2022;8:411-422.
doi:10.1007/s40598-022-00198-y
apa: 'Bialy, M., Fiorebe, C., Glutsyuk, A., Levi, M., Plakhov, A., & Tabachnikov,
S. (2022). Open problems on billiards and geometric optics. Arnold Mathematical
Journal. Hybrid: Springer Nature. https://doi.org/10.1007/s40598-022-00198-y'
chicago: Bialy, Misha, Corentin Fiorebe, Alexey Glutsyuk, Mark Levi, Alexander Plakhov,
and Serge Tabachnikov. “Open Problems on Billiards and Geometric Optics.” Arnold
Mathematical Journal. Springer Nature, 2022. https://doi.org/10.1007/s40598-022-00198-y.
ieee: M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, and S. Tabachnikov,
“Open problems on billiards and geometric optics,” Arnold Mathematical Journal,
vol. 8. Springer Nature, pp. 411–422, 2022.
ista: Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. 2022. Open
problems on billiards and geometric optics. Arnold Mathematical Journal. 8, 411–422.
mla: Bialy, Misha, et al. “Open Problems on Billiards and Geometric Optics.” Arnold
Mathematical Journal, vol. 8, Springer Nature, 2022, pp. 411–22, doi:10.1007/s40598-022-00198-y.
short: M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, S. Tabachnikov, Arnold
Mathematical Journal 8 (2022) 411–422.
conference:
end_date: 2021-10-08
location: Hybrid
name: 'CIRM: Centre International de Rencontres Mathématiques'
start_date: 2021-10-04
date_created: 2022-01-30T23:01:34Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2023-02-27T07:34:08Z
day: '01'
department:
- _id: VaKa
doi: 10.1007/s40598-022-00198-y
external_id:
arxiv:
- '2110.10750'
intvolume: ' 8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2110.10750
month: '10'
oa: 1
oa_version: Preprint
page: 411-422
publication: Arnold Mathematical Journal
publication_identifier:
eissn:
- 2199-6806
issn:
- 2199-6792
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://conferences.cirm-math.fr/2383.html
scopus_import: '1'
status: public
title: Open problems on billiards and geometric optics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2022'
...
---
_id: '10712'
abstract:
- lang: eng
text: Solute carriers are increasingly recognized as participating in a plethora
of pathologies, including cancer. We describe here the involvement of the orphan
solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1
enabled higher levels of metastasis in a mouse model. We identified an increased
migratory potential in MFSD1-/- tumor cells which was mediated by increased focal
adhesion turn-over, reduced stability of mature inactive β1 integrin, and the
resulting increased integrin activation index. We show that MFSD1 promoted recycling
to the cell surface of endocytosed inactive β1 integrin and thereby protected
β1 integrin from proteolytic degradation; this led to dampening of the integrin
activation index. Furthermore, down-regulation of MFSD1 expression was observed
during early steps of tumorigenesis and higher MFSD1 expression levels correlate
with a better cancer patient prognosis. In sum, we describe a requirement for
endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.
acknowledged_ssus:
- _id: Bio
acknowledgement: We thank M. Sixt, A. Leithner, and J. Alanko for helpful advice and
the BioImaging Facility at IST Austria for technical support and assistance. We
thank the Siekhaus Lab for the careful review of the manuscript and their input.
MR and DS were funded by the NO Forschungs- und Bildungsges.m.b.H. (LS16-021) and
IST core funding. MD was funded by Deutsche Forschungsgemeinschaft (DA 1785-1).
article_number: '777634'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: Julia
full_name: Bicher, Julia
id: 3CCBB46E-F248-11E8-B48F-1D18A9856A87
last_name: Bicher
- first_name: Merel
full_name: van Gogh, Merel
last_name: van Gogh
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Rita
full_name: Seeböck, Rita
last_name: Seeböck
- first_name: Bozena
full_name: Szulc, Bozena
last_name: Szulc
- first_name: Markus
full_name: Damme, Markus
last_name: Damme
- first_name: Mariusz
full_name: Olczak, Mariusz
last_name: Olczak
- first_name: Lubor
full_name: Borsig, Lubor
last_name: Borsig
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Roblek M, Bicher J, van Gogh M, et al. The solute carrier MFSD1 decreases β1
integrin’s activation status and thus tumor metastasis. Frontiers in Oncology.
2022;12. doi:10.3389/fonc.2022.777634
apa: Roblek, M., Bicher, J., van Gogh, M., György, A., Seeböck, R., Szulc, B., …
Siekhaus, D. E. (2022). The solute carrier MFSD1 decreases β1 integrin’s activation
status and thus tumor metastasis. Frontiers in Oncology. Frontiers. https://doi.org/10.3389/fonc.2022.777634
chicago: Roblek, Marko, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck,
Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, and Daria E Siekhaus.
“The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor
Metastasis.” Frontiers in Oncology. Frontiers, 2022. https://doi.org/10.3389/fonc.2022.777634.
ieee: M. Roblek et al., “The solute carrier MFSD1 decreases β1 integrin’s
activation status and thus tumor metastasis,” Frontiers in Oncology, vol.
12. Frontiers, 2022.
ista: Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak
M, Borsig L, Siekhaus DE. 2022. The solute carrier MFSD1 decreases β1 integrin’s
activation status and thus tumor metastasis. Frontiers in Oncology. 12, 777634.
mla: Roblek, Marko, et al. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation
Status and Thus Tumor Metastasis.” Frontiers in Oncology, vol. 12, 777634,
Frontiers, 2022, doi:10.3389/fonc.2022.777634.
short: M. Roblek, J. Bicher, M. van Gogh, A. György, R. Seeböck, B. Szulc, M. Damme,
M. Olczak, L. Borsig, D.E. Siekhaus, Frontiers in Oncology 12 (2022).
date_created: 2022-02-01T10:33:50Z
date_published: 2022-02-08T00:00:00Z
date_updated: 2023-08-02T14:05:44Z
day: '08'
ddc:
- '570'
department:
- _id: DaSi
doi: 10.3389/fonc.2022.777634
external_id:
isi:
- '000760618800001'
file:
- access_level: open_access
checksum: 63dfecf30c5bbf9408b3512bd603f78c
content_type: application/pdf
creator: cchlebak
date_created: 2022-02-08T13:26:40Z
date_updated: 2022-02-08T13:26:40Z
file_id: '10751'
file_name: 2022_FrontiersOncol_Roblek.pdf
file_size: 6303227
relation: main_file
success: 1
file_date_updated: 2022-02-08T13:26:40Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 2637E9C0-B435-11E9-9278-68D0E5697425
grant_number: 'LSC16-021 '
name: Investigating the role of the novel major superfamily facilitator transporter
family member MFSD1 in metastasis
publication: Frontiers in Oncology
publication_identifier:
issn:
- 2234-943X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: confirmation
url: https://ist.ac.at/en/news/suppressing-the-spread-of-tumors/
scopus_import: '1'
status: public
title: The solute carrier MFSD1 decreases β1 integrin’s activation status and thus
tumor metastasis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '10713'
abstract:
- lang: eng
text: Cells migrate through crowded microenvironments within tissues during normal
development, immune response, and cancer metastasis. Although migration through
pores and tracks in the extracellular matrix (ECM) has been well studied, little
is known about cellular traversal into confining cell-dense tissues. We find that
embryonic tissue invasion by Drosophila macrophages requires division of an epithelial
ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM
attachment formed by integrin-mediated focal adhesions next to mesodermal cells,
allowing macrophages to move their nuclei ahead and invade between two immediately
adjacent tissues. Invasion efficiency depends on division frequency, but reduction
of adhesion strength allows macrophage entry independently of division. This work
demonstrates that tissue dynamics can regulate cellular infiltration.
acknowledged_ssus:
- _id: Bio
acknowledgement: 'We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of
the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria
for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly
strains. This work was supported by a grant from the Austrian Science Fund FWF:
Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST
Austria to D.S. and EMBL to S.D.R.'
article_processing_charge: No
article_type: original
author:
- first_name: Maria
full_name: Akhmanova, Maria
id: 3425EC26-F248-11E8-B48F-1D18A9856A87
last_name: Akhmanova
orcid: 0000-0003-1522-3162
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Daniel
full_name: Krueger, Daniel
last_name: Krueger
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Mariana
full_name: Pereira Guarda, Mariana
id: 6de81d9d-e2f2-11eb-945a-af8bc2a60b26
last_name: Pereira Guarda
- first_name: Mikhail
full_name: Vlasov, Mikhail
last_name: Vlasov
- first_name: Fedor
full_name: Vlasov, Fedor
last_name: Vlasov
- first_name: Andrei
full_name: Akopian, Andrei
last_name: Akopian
- first_name: Aparna
full_name: Ratheesh, Aparna
id: 2F064CFE-F248-11E8-B48F-1D18A9856A87
last_name: Ratheesh
- first_name: Stefano
full_name: De Renzis, Stefano
last_name: De Renzis
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables
macrophage infiltration. Science. 2022;376(6591):394-396. doi:10.1126/science.abj0425
apa: Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov,
M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.abj0425
chicago: Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana
Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues
Enables Macrophage Infiltration.” Science. American Association for the
Advancement of Science, 2022. https://doi.org/10.1126/science.abj0425.
ieee: M. Akhmanova et al., “Cell division in tissues enables macrophage infiltration,”
Science, vol. 376, no. 6591. American Association for the Advancement of
Science, pp. 394–396, 2022.
ista: Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M,
Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division
in tissues enables macrophage infiltration. Science. 376(6591), 394–396.
mla: Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.”
Science, vol. 376, no. 6591, American Association for the Advancement of
Science, 2022, pp. 394–96, doi:10.1126/science.abj0425.
short: M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov,
F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022)
394–396.
date_created: 2022-02-01T11:23:18Z
date_published: 2022-04-22T00:00:00Z
date_updated: 2023-08-02T14:06:15Z
day: '22'
department:
- _id: DaSi
doi: 10.1126/science.abj0425
external_id:
isi:
- '000788553700039'
pmid:
- '35446632'
intvolume: ' 376'
isi: 1
issue: '6591'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2021.04.19.438995
month: '04'
oa: 1
oa_version: Preprint
page: 394-396
pmid: 1
project:
- _id: 264CBBAC-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02379
name: Modeling epithelial tissue mechanics during cell invasion
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Cell division in tissues enables macrophage infiltration
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 376
year: '2022'
...