---
_id: '1297'
abstract:
- lang: eng
text: In flies, the large tangential cells of the lobula plate represent an important
processing center for visual navigation based on optic flow. Although the visual
response properties of these cells have been well studied in blowflies, information
on their synaptic organization is mostly lacking. Here we study the distribution
of presynaptic release and postsynaptic inhibitory sites in the same set of cells
in Drosophila melanogaster. By making use of transgenic tools and immunohistochemistry,
our results suggest that HS and VS cells of Drosophila express γ-aminobutyric
acid (GABA) receptors in their dendritic region within the lobula plate, thus
being postsynaptic to inhibitory input there. At their axon terminals in the protocerebrum,
both cell types express synaptobrevin, suggesting the presence of presynaptic
specializations there. HS- and VS-cell terminals additionally show evidence for
postsynaptic GABAergic input, superimposed on this synaptic polarity. Our findings
are in line with the general circuit for visual motion detection and receptive
field properties as postulated from electrophysiological and optical recordings
in blowflies, suggesting a similar functional organization of lobula plate tangential
cells in the two species.
author:
- first_name: Shamprasad
full_name: Raghu, Shamprasad V
last_name: Raghu
- first_name: Maximilian A
full_name: Maximilian Jösch
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
- first_name: Alexander
full_name: Borst, Alexander
last_name: Borst
- first_name: Dierk
full_name: Reiff, Dierk F
last_name: Reiff
citation:
ama: 'Raghu S, Jösch MA, Borst A, Reiff D. Synaptic organization of lobula plate
tangential cells in Drosophila: γ-aminobutyric acid receptors and chemical release
sites. Journal of Comparative Neurology. 2007;502(4):598-610. doi:10.1002/cne.21319'
apa: 'Raghu, S., Jösch, M. A., Borst, A., & Reiff, D. (2007). Synaptic organization
of lobula plate tangential cells in Drosophila: γ-aminobutyric acid receptors
and chemical release sites. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.21319'
chicago: 'Raghu, Shamprasad, Maximilian A Jösch, Alexander Borst, and Dierk Reiff.
“Synaptic Organization of Lobula Plate Tangential Cells in Drosophila: γ-Aminobutyric
Acid Receptors and Chemical Release Sites.” Journal of Comparative Neurology.
Wiley-Blackwell, 2007. https://doi.org/10.1002/cne.21319.'
ieee: 'S. Raghu, M. A. Jösch, A. Borst, and D. Reiff, “Synaptic organization of
lobula plate tangential cells in Drosophila: γ-aminobutyric acid receptors and
chemical release sites,” Journal of Comparative Neurology, vol. 502, no.
4. Wiley-Blackwell, pp. 598–610, 2007.'
ista: 'Raghu S, Jösch MA, Borst A, Reiff D. 2007. Synaptic organization of lobula
plate tangential cells in Drosophila: γ-aminobutyric acid receptors and chemical
release sites. Journal of Comparative Neurology. 502(4), 598–610.'
mla: 'Raghu, Shamprasad, et al. “Synaptic Organization of Lobula Plate Tangential
Cells in Drosophila: γ-Aminobutyric Acid Receptors and Chemical Release Sites.”
Journal of Comparative Neurology, vol. 502, no. 4, Wiley-Blackwell, 2007,
pp. 598–610, doi:10.1002/cne.21319.'
short: S. Raghu, M.A. Jösch, A. Borst, D. Reiff, Journal of Comparative Neurology
502 (2007) 598–610.
date_created: 2018-12-11T11:51:13Z
date_published: 2007-06-01T00:00:00Z
date_updated: 2021-01-12T06:49:42Z
day: '01'
doi: 10.1002/cne.21319
extern: 1
intvolume: ' 502'
issue: '4'
month: '06'
page: 598 - 610
publication: Journal of Comparative Neurology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5974'
quality_controlled: 0
status: public
title: 'Synaptic organization of lobula plate tangential cells in Drosophila: γ-aminobutyric
acid receptors and chemical release sites'
type: journal_article
volume: 502
year: '2007'
...
---
_id: '8483'
abstract:
- lang: eng
text: Atom-resolved real-time studies of kinetic processes in proteins have been
hampered in the past by the lack of experimental techniques that yield sufficient
temporal and atomic resolution. Here we present band-selective optimized flip-angle
short transient (SOFAST) real-time 2D NMR spectroscopy, a method that allows simultaneous
observation of reaction kinetics for a large number of nuclear sites along the
polypeptide chain of a protein with an unprecedented time resolution of a few
seconds. SOFAST real-time 2D NMR spectroscopy combines fast NMR data acquisition
techniques with rapid sample mixing inside the NMR magnet to initiate the kinetic
event. We demonstrate the use of SOFAST real-time 2D NMR to monitor the conformational
transition of α-lactalbumin from a molten globular to the native state for a large
number of amide sites along the polypeptide chain. The kinetic behavior observed
for the disappearance of the molten globule and the appearance of the native state
is monoexponential and uniform along the polypeptide chain. This observation confirms
previous findings that a single transition state ensemble controls folding of
α-lactalbumin from the molten globule to the native state. In a second application,
the spontaneous unfolding of native ubiquitin under nondenaturing conditions is
characterized by amide hydrogen exchange rate constants measured at high pH by
using SOFAST real-time 2D NMR. Our data reveal that ubiquitin unfolds in a gradual
manner with distinct unfolding regimes.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: V.
full_name: Forge, V.
last_name: Forge
- first_name: B.
full_name: Brutscher, B.
last_name: Brutscher
citation:
ama: Schanda P, Forge V, Brutscher B. Protein folding and unfolding studied at atomic
resolution by fast two-dimensional NMR spectroscopy. Proceedings of the National
Academy of Sciences. 2007;104(27):11257-11262. doi:10.1073/pnas.0702069104
apa: Schanda, P., Forge, V., & Brutscher, B. (2007). Protein folding and unfolding
studied at atomic resolution by fast two-dimensional NMR spectroscopy. Proceedings
of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.0702069104
chicago: Schanda, Paul, V. Forge, and B. Brutscher. “Protein Folding and Unfolding
Studied at Atomic Resolution by Fast Two-Dimensional NMR Spectroscopy.” Proceedings
of the National Academy of Sciences. National Academy of Sciences, 2007. https://doi.org/10.1073/pnas.0702069104.
ieee: P. Schanda, V. Forge, and B. Brutscher, “Protein folding and unfolding studied
at atomic resolution by fast two-dimensional NMR spectroscopy,” Proceedings
of the National Academy of Sciences, vol. 104, no. 27. National Academy of
Sciences, pp. 11257–11262, 2007.
ista: Schanda P, Forge V, Brutscher B. 2007. Protein folding and unfolding studied
at atomic resolution by fast two-dimensional NMR spectroscopy. Proceedings of
the National Academy of Sciences. 104(27), 11257–11262.
mla: Schanda, Paul, et al. “Protein Folding and Unfolding Studied at Atomic Resolution
by Fast Two-Dimensional NMR Spectroscopy.” Proceedings of the National Academy
of Sciences, vol. 104, no. 27, National Academy of Sciences, 2007, pp. 11257–62,
doi:10.1073/pnas.0702069104.
short: P. Schanda, V. Forge, B. Brutscher, Proceedings of the National Academy of
Sciences 104 (2007) 11257–11262.
date_created: 2020-09-18T10:12:54Z
date_published: 2007-07-03T00:00:00Z
date_updated: 2021-01-12T08:19:35Z
day: '03'
doi: 10.1073/pnas.0702069104
extern: '1'
intvolume: ' 104'
issue: '27'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '07'
oa_version: None
page: 11257-11262
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
status: public
title: Protein folding and unfolding studied at atomic resolution by fast two-dimensional
NMR spectroscopy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 104
year: '2007'
...
---
_id: '8484'
abstract:
- lang: eng
text: A series of sequential, intra-residue, and bi-directional BEST H–N–CA, H–N–CO,
and H–N–CB pulse sequences is presented that extends the BEST concept introduced
recently for fast multidimensional protein NMR [Schanda et al., J. Am. Chem. Soc.
128 (2006) 9042] to the complete set of experiments required for sequential resonance
assignment. We demonstrate for the protein ubiquitin that 3D BEST H–N–C correlation
spectra can be recorded on a 600 MHz NMR spectrometer equipped with a cryogenic
probe in only a few minutes of acquisition time with sufficient sensitivity to
detect all expected cross peaks.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ewen
full_name: Lescop, Ewen
last_name: Lescop
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Lescop E, Schanda P, Brutscher B. A set of BEST triple-resonance experiments
for time-optimized protein resonance assignment. Journal of Magnetic Resonance.
2007;187(1):163-169. doi:10.1016/j.jmr.2007.04.002
apa: Lescop, E., Schanda, P., & Brutscher, B. (2007). A set of BEST triple-resonance
experiments for time-optimized protein resonance assignment. Journal of Magnetic
Resonance. Elsevier. https://doi.org/10.1016/j.jmr.2007.04.002
chicago: Lescop, Ewen, Paul Schanda, and Bernhard Brutscher. “A Set of BEST Triple-Resonance
Experiments for Time-Optimized Protein Resonance Assignment.” Journal of Magnetic
Resonance. Elsevier, 2007. https://doi.org/10.1016/j.jmr.2007.04.002.
ieee: E. Lescop, P. Schanda, and B. Brutscher, “A set of BEST triple-resonance experiments
for time-optimized protein resonance assignment,” Journal of Magnetic Resonance,
vol. 187, no. 1. Elsevier, pp. 163–169, 2007.
ista: Lescop E, Schanda P, Brutscher B. 2007. A set of BEST triple-resonance experiments
for time-optimized protein resonance assignment. Journal of Magnetic Resonance.
187(1), 163–169.
mla: Lescop, Ewen, et al. “A Set of BEST Triple-Resonance Experiments for Time-Optimized
Protein Resonance Assignment.” Journal of Magnetic Resonance, vol. 187,
no. 1, Elsevier, 2007, pp. 163–69, doi:10.1016/j.jmr.2007.04.002.
short: E. Lescop, P. Schanda, B. Brutscher, Journal of Magnetic Resonance 187 (2007)
163–169.
date_created: 2020-09-18T10:13:02Z
date_published: 2007-07-01T00:00:00Z
date_updated: 2021-01-12T08:19:35Z
day: '01'
doi: 10.1016/j.jmr.2007.04.002
extern: '1'
intvolume: ' 187'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 163-169
publication: Journal of Magnetic Resonance
publication_identifier:
issn:
- 1090-7807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: A set of BEST triple-resonance experiments for time-optimized protein resonance
assignment
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 187
year: '2007'
...
---
_id: '8485'
abstract:
- lang: eng
text: High signal to noise is a necessity for the quantification of NMR spectral
parameters to be translated into accurate and precise restraints on protein structure
and dynamics. An important source of long-range structural information is obtained
from 1H–1H residual dipolar couplings (RDCs) measured for weakly aligned molecules.
For sensitivity reasons, such measurements are generally performed on highly deuterated
protein samples. Here we show that high sensitivity is also obtained for protonated
protein samples if the pulse schemes are optimized in terms of longitudinal relaxation
efficiency and J-mismatch compensated coherence transfer. The new sensitivity-optimized
quantitative J-correlation experiment yields important signal gains reaching factors
of 1.5 to 8 for individual correlation peaks when compared to previously proposed
pulse schemes.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Ewen
full_name: Lescop, Ewen
last_name: Lescop
- first_name: Mirjam
full_name: Falge, Mirjam
last_name: Falge
- first_name: Rémy
full_name: Sounier, Rémy
last_name: Sounier
- first_name: Jérôme
full_name: Boisbouvier, Jérôme
last_name: Boisbouvier
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Schanda P, Lescop E, Falge M, Sounier R, Boisbouvier J, Brutscher B. Sensitivity-optimized
experiment for the measurement of residual dipolar couplings between amide protons.
Journal of Biomolecular NMR. 2007;38:47-55. doi:10.1007/s10858-006-9138-2
apa: Schanda, P., Lescop, E., Falge, M., Sounier, R., Boisbouvier, J., & Brutscher,
B. (2007). Sensitivity-optimized experiment for the measurement of residual dipolar
couplings between amide protons. Journal of Biomolecular NMR. Springer
Nature. https://doi.org/10.1007/s10858-006-9138-2
chicago: Schanda, Paul, Ewen Lescop, Mirjam Falge, Rémy Sounier, Jérôme Boisbouvier,
and Bernhard Brutscher. “Sensitivity-Optimized Experiment for the Measurement
of Residual Dipolar Couplings between Amide Protons.” Journal of Biomolecular
NMR. Springer Nature, 2007. https://doi.org/10.1007/s10858-006-9138-2.
ieee: P. Schanda, E. Lescop, M. Falge, R. Sounier, J. Boisbouvier, and B. Brutscher,
“Sensitivity-optimized experiment for the measurement of residual dipolar couplings
between amide protons,” Journal of Biomolecular NMR, vol. 38. Springer
Nature, pp. 47–55, 2007.
ista: Schanda P, Lescop E, Falge M, Sounier R, Boisbouvier J, Brutscher B. 2007.
Sensitivity-optimized experiment for the measurement of residual dipolar couplings
between amide protons. Journal of Biomolecular NMR. 38, 47–55.
mla: Schanda, Paul, et al. “Sensitivity-Optimized Experiment for the Measurement
of Residual Dipolar Couplings between Amide Protons.” Journal of Biomolecular
NMR, vol. 38, Springer Nature, 2007, pp. 47–55, doi:10.1007/s10858-006-9138-2.
short: P. Schanda, E. Lescop, M. Falge, R. Sounier, J. Boisbouvier, B. Brutscher,
Journal of Biomolecular NMR 38 (2007) 47–55.
date_created: 2020-09-18T10:13:12Z
date_published: 2007-03-08T00:00:00Z
date_updated: 2021-01-12T08:19:36Z
day: '08'
doi: 10.1007/s10858-006-9138-2
extern: '1'
intvolume: ' 38'
keyword:
- Spectroscopy
- Biochemistry
language:
- iso: eng
month: '03'
oa_version: None
page: 47-55
publication: Journal of Biomolecular NMR
publication_identifier:
issn:
- 0925-2738
- 1573-5001
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Sensitivity-optimized experiment for the measurement of residual dipolar couplings
between amide protons
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2007'
...
---
_id: '8486'
abstract:
- lang: eng
text: A technique is described that allows reducing acquisition times of multidimensional
NMR experiments by extensive spectral folding. The method is simple and has many
interesting applications for NMR studies of molecular structure, dynamics, and
kinetics.
article_processing_charge: No
article_type: original
author:
- first_name: Ewen
full_name: Lescop, Ewen
last_name: Lescop
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Rodolfo
full_name: Rasia, Rodolfo
last_name: Rasia
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
citation:
ama: Lescop E, Schanda P, Rasia R, Brutscher B. Automated spectral compression for
fast multidimensional NMR and increased time resolution in real-time NMR spectroscopy.
Journal of the American Chemical Society. 2007;129(10):2756-2757. doi:10.1021/ja068949u
apa: Lescop, E., Schanda, P., Rasia, R., & Brutscher, B. (2007). Automated spectral
compression for fast multidimensional NMR and increased time resolution in real-time
NMR spectroscopy. Journal of the American Chemical Society. American Chemical
Society. https://doi.org/10.1021/ja068949u
chicago: Lescop, Ewen, Paul Schanda, Rodolfo Rasia, and Bernhard Brutscher. “Automated
Spectral Compression for Fast Multidimensional NMR and Increased Time Resolution
in Real-Time NMR Spectroscopy.” Journal of the American Chemical Society.
American Chemical Society, 2007. https://doi.org/10.1021/ja068949u.
ieee: E. Lescop, P. Schanda, R. Rasia, and B. Brutscher, “Automated spectral compression
for fast multidimensional NMR and increased time resolution in real-time NMR spectroscopy,”
Journal of the American Chemical Society, vol. 129, no. 10. American Chemical
Society, pp. 2756–2757, 2007.
ista: Lescop E, Schanda P, Rasia R, Brutscher B. 2007. Automated spectral compression
for fast multidimensional NMR and increased time resolution in real-time NMR spectroscopy.
Journal of the American Chemical Society. 129(10), 2756–2757.
mla: Lescop, Ewen, et al. “Automated Spectral Compression for Fast Multidimensional
NMR and Increased Time Resolution in Real-Time NMR Spectroscopy.” Journal of
the American Chemical Society, vol. 129, no. 10, American Chemical Society,
2007, pp. 2756–57, doi:10.1021/ja068949u.
short: E. Lescop, P. Schanda, R. Rasia, B. Brutscher, Journal of the American Chemical
Society 129 (2007) 2756–2757.
date_created: 2020-09-18T10:13:21Z
date_published: 2007-02-17T00:00:00Z
date_updated: 2021-01-12T08:19:36Z
day: '17'
doi: 10.1021/ja068949u
extern: '1'
intvolume: ' 129'
issue: '10'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '02'
oa_version: None
page: 2756-2757
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Automated spectral compression for fast multidimensional NMR and increased
time resolution in real-time NMR spectroscopy
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 129
year: '2007'
...
---
_id: '8487'
abstract:
- lang: eng
text: Following unidirectional biophysical events such as the folding of proteins
or the equilibration of binding interactions, requires experimental methods that
yield information at both atomic-level resolution and at high repetition rates.
Toward this end a number of different approaches enabling the rapid acquisition
of 2D NMR spectra have been recently introduced, including spatially encoded “ultrafast”
2D NMR spectroscopy and SOFAST HMQC NMR. Whereas the former accelerates acquisitions
by reducing the number of scans that are necessary for completing arbitrary 2D
NMR experiments, the latter operates by reducing the delay between consecutive
scans while preserving sensitivity. Given the complementarities between these
two approaches it seems natural to combine them into a single tool, enabling the
acquisition of full 2D protein NMR spectra at high repetition rates. We demonstrate
here this capability with the introduction of “ultraSOFAST” HMQC NMR, a spatially
encoded and relaxation-optimized approach that can provide 2D protein correlation
spectra at ∼1 s repetition rates for samples in the ∼2 mM concentration range.
The principles, relative advantages, and current limitations of this new approach
are discussed, and its application is exemplified with a study of the fast hydrogen−deuterium
exchange characterizing amide sites in Ubiquitin.
article_processing_charge: No
article_type: original
author:
- first_name: Maayan
full_name: Gal, Maayan
last_name: Gal
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- first_name: Bernhard
full_name: Brutscher, Bernhard
last_name: Brutscher
- first_name: Lucio
full_name: Frydman, Lucio
last_name: Frydman
citation:
ama: Gal M, Schanda P, Brutscher B, Frydman L. UltraSOFAST HMQC NMR and the repetitive
acquisition of 2D protein spectra at Hz rates. Journal of the American Chemical
Society. 2007;129(5):1372-1377. doi:10.1021/ja066915g
apa: Gal, M., Schanda, P., Brutscher, B., & Frydman, L. (2007). UltraSOFAST
HMQC NMR and the repetitive acquisition of 2D protein spectra at Hz rates. Journal
of the American Chemical Society. American Chemical Society. https://doi.org/10.1021/ja066915g
chicago: Gal, Maayan, Paul Schanda, Bernhard Brutscher, and Lucio Frydman. “UltraSOFAST
HMQC NMR and the Repetitive Acquisition of 2D Protein Spectra at Hz Rates.” Journal
of the American Chemical Society. American Chemical Society, 2007. https://doi.org/10.1021/ja066915g.
ieee: M. Gal, P. Schanda, B. Brutscher, and L. Frydman, “UltraSOFAST HMQC NMR and
the repetitive acquisition of 2D protein spectra at Hz rates,” Journal of the
American Chemical Society, vol. 129, no. 5. American Chemical Society, pp.
1372–1377, 2007.
ista: Gal M, Schanda P, Brutscher B, Frydman L. 2007. UltraSOFAST HMQC NMR and the
repetitive acquisition of 2D protein spectra at Hz rates. Journal of the American
Chemical Society. 129(5), 1372–1377.
mla: Gal, Maayan, et al. “UltraSOFAST HMQC NMR and the Repetitive Acquisition of
2D Protein Spectra at Hz Rates.” Journal of the American Chemical Society,
vol. 129, no. 5, American Chemical Society, 2007, pp. 1372–77, doi:10.1021/ja066915g.
short: M. Gal, P. Schanda, B. Brutscher, L. Frydman, Journal of the American Chemical
Society 129 (2007) 1372–1377.
date_created: 2020-09-18T10:13:27Z
date_published: 2007-01-10T00:00:00Z
date_updated: 2021-01-12T08:19:37Z
day: '10'
doi: 10.1021/ja066915g
extern: '1'
intvolume: ' 129'
issue: '5'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '01'
oa_version: None
page: 1372-1377
publication: Journal of the American Chemical Society
publication_identifier:
issn:
- 0002-7863
- 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: UltraSOFAST HMQC NMR and the repetitive acquisition of 2D protein spectra at
Hz rates
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 129
year: '2007'
...
---
_id: '8511'
abstract:
- lang: eng
text: "Here we study an amazing phenomenon discovered by Newhouse [S. Newhouse,
Non-density of Axiom A(a) on S2, in: Proc. Sympos. Pure Math., vol. 14, Amer.
Math. Soc., 1970, pp. 191–202; S. Newhouse,\r\nDiffeomorphisms with infinitely
many sinks, Topology 13 (1974) 9–18; S. Newhouse, The abundance of\r\nwild hyperbolic
sets and nonsmooth stable sets of diffeomorphisms, Publ. Math. Inst. Hautes Études
Sci.\r\n50 (1979) 101–151]. It turns out that in the space of Cr smooth diffeomorphisms
Diffr(M) of a compact\r\nsurface M there is an open set U such that a Baire generic
diffeomorphism f ∈ U has infinitely many coexisting sinks. In this paper we make
a step towards understanding “how often does a surface diffeomorphism\r\nhave
infinitely many sinks.” Our main result roughly says that with probability one
for any positive D a\r\nsurface diffeomorphism has only finitely many localized
sinks either of cyclicity bounded by D or those\r\nwhose period is relatively
large compared to its cyclicity. It verifies a particular case of Palis’ Conjecture\r\nsaying
that even though diffeomorphisms with infinitely many coexisting sinks are Baire
generic, they have\r\nprobability zero.\r\nOne of the key points of the proof
is an application of Newton Interpolation Polynomials to study the dynamics initiated
in [V. Kaloshin, B. Hunt, A stretched exponential bound on the rate of growth
of the number\r\nof periodic points for prevalent diffeomorphisms I, Ann. of Math.,
in press, 92 pp.; V. Kaloshin, A stretched\r\nexponential bound on the rate of
growth of the number of periodic points for prevalent diffeomorphisms II,\r\npreprint,
85 pp.]."
article_processing_charge: No
article_type: original
author:
- first_name: A.
full_name: Gorodetski, A.
last_name: Gorodetski
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
citation:
ama: Gorodetski A, Kaloshin V. How often surface diffeomorphisms have infinitely
many sinks and hyperbolicity of periodic points near a homoclinic tangency. Advances
in Mathematics. 2007;208(2):710-797. doi:10.1016/j.aim.2006.03.012
apa: Gorodetski, A., & Kaloshin, V. (2007). How often surface diffeomorphisms
have infinitely many sinks and hyperbolicity of periodic points near a homoclinic
tangency. Advances in Mathematics. Elsevier. https://doi.org/10.1016/j.aim.2006.03.012
chicago: Gorodetski, A., and Vadim Kaloshin. “How Often Surface Diffeomorphisms
Have Infinitely Many Sinks and Hyperbolicity of Periodic Points near a Homoclinic
Tangency.” Advances in Mathematics. Elsevier, 2007. https://doi.org/10.1016/j.aim.2006.03.012.
ieee: A. Gorodetski and V. Kaloshin, “How often surface diffeomorphisms have infinitely
many sinks and hyperbolicity of periodic points near a homoclinic tangency,” Advances
in Mathematics, vol. 208, no. 2. Elsevier, pp. 710–797, 2007.
ista: Gorodetski A, Kaloshin V. 2007. How often surface diffeomorphisms have infinitely
many sinks and hyperbolicity of periodic points near a homoclinic tangency. Advances
in Mathematics. 208(2), 710–797.
mla: Gorodetski, A., and Vadim Kaloshin. “How Often Surface Diffeomorphisms Have
Infinitely Many Sinks and Hyperbolicity of Periodic Points near a Homoclinic Tangency.”
Advances in Mathematics, vol. 208, no. 2, Elsevier, 2007, pp. 710–97, doi:10.1016/j.aim.2006.03.012.
short: A. Gorodetski, V. Kaloshin, Advances in Mathematics 208 (2007) 710–797.
date_created: 2020-09-18T10:48:27Z
date_published: 2007-01-30T00:00:00Z
date_updated: 2021-01-12T08:19:47Z
day: '30'
doi: 10.1016/j.aim.2006.03.012
extern: '1'
intvolume: ' 208'
issue: '2'
keyword:
- General Mathematics
language:
- iso: eng
month: '01'
oa_version: None
page: 710-797
publication: Advances in Mathematics
publication_identifier:
issn:
- 0001-8708
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: How often surface diffeomorphisms have infinitely many sinks and hyperbolicity
of periodic points near a homoclinic tangency
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 208
year: '2007'
...
---
_id: '8512'
abstract:
- lang: eng
text: "For diffeomorphisms of smooth compact finite-dimensional manifolds, we consider
the problem of how fast the number of periodic points with period n grows as a
function of n. In many familiar cases (e.g., Anosov systems) the growth is exponential,
but arbitrarily fast growth is possible; in fact, the first author has shown that
arbitrarily fast growth is topologically (Baire) generic for C2 or smoother diffeomorphisms.
In the present work we show that, by contrast, for a measure-theoretic notion
of genericity we call “prevalence”, the growth is not much faster than exponential.
Specifically, we show that for each ρ,δ>0, there is a prevalent set of C1+ρ (or
smoother) diffeomorphisms for which the number of periodic n points is bounded
above by exp(Cn1+δ) for some C independent of n. We also obtain a related bound
on the decay of hyperbolicity of the periodic points as a function of n, and obtain
the same results for 1-dimensional endomorphisms. The contrast between topologically
generic and measure-theoretically generic behavior for the growth of the number
of periodic points and the decay of their hyperbolicity show this to be a subtle
and complex phenomenon, reminiscent of KAM theory. Here in Part I we state our
results and describe the methods we use. We complete most of the proof in the
1-dimensional C2-smooth case and outline the remaining steps, deferred to Part
II, that are needed to establish the general case.\r\n\r\nThe novel feature of
the approach we develop in this paper is the introduction of Newton Interpolation
Polynomials as a tool for perturbing trajectories of iterated maps."
article_processing_charge: No
article_type: original
author:
- first_name: Vadim
full_name: Kaloshin, Vadim
id: FE553552-CDE8-11E9-B324-C0EBE5697425
last_name: Kaloshin
orcid: 0000-0002-6051-2628
- first_name: Brian
full_name: Hunt, Brian
last_name: Hunt
citation:
ama: Kaloshin V, Hunt B. Stretched exponential estimates on growth of the number
of periodic points for prevalent diffeomorphisms I. Annals of Mathematics.
2007;165(1):89-170. doi:10.4007/annals.2007.165.89
apa: Kaloshin, V., & Hunt, B. (2007). Stretched exponential estimates on growth
of the number of periodic points for prevalent diffeomorphisms I. Annals of
Mathematics. Princeton University Press. https://doi.org/10.4007/annals.2007.165.89
chicago: Kaloshin, Vadim, and Brian Hunt. “Stretched Exponential Estimates on Growth
of the Number of Periodic Points for Prevalent Diffeomorphisms I.” Annals of
Mathematics. Princeton University Press, 2007. https://doi.org/10.4007/annals.2007.165.89.
ieee: V. Kaloshin and B. Hunt, “Stretched exponential estimates on growth of the
number of periodic points for prevalent diffeomorphisms I,” Annals of Mathematics,
vol. 165, no. 1. Princeton University Press, pp. 89–170, 2007.
ista: Kaloshin V, Hunt B. 2007. Stretched exponential estimates on growth of the
number of periodic points for prevalent diffeomorphisms I. Annals of Mathematics.
165(1), 89–170.
mla: Kaloshin, Vadim, and Brian Hunt. “Stretched Exponential Estimates on Growth
of the Number of Periodic Points for Prevalent Diffeomorphisms I.” Annals of
Mathematics, vol. 165, no. 1, Princeton University Press, 2007, pp. 89–170,
doi:10.4007/annals.2007.165.89.
short: V. Kaloshin, B. Hunt, Annals of Mathematics 165 (2007) 89–170.
date_created: 2020-09-18T10:48:33Z
date_published: 2007-01-01T00:00:00Z
date_updated: 2021-01-12T08:19:48Z
day: '01'
doi: 10.4007/annals.2007.165.89
extern: '1'
intvolume: ' 165'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 89-170
publication: Annals of Mathematics
publication_identifier:
issn:
- 0003-486X
publication_status: published
publisher: Princeton University Press
quality_controlled: '1'
status: public
title: Stretched exponential estimates on growth of the number of periodic points
for prevalent diffeomorphisms I
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 165
year: '2007'
...
---
_id: '860'
abstract:
- lang: eng
text: We identified a mutation in the CRYGD gene (P23S) of the γ-crystallin gene
cluster that is associated with a polymorphic congenital cataract that occurs
with frequency of ∼0.3% in a human population. To gain insight into the molecular
mechanism of the pathogenesis of γ-crystallin isoforms, we undertook an evolutionary
analysis of the available mammalian and newly obtained primate sequences of the
γ-crystallin genes. The cataract-associated serine at site 23 corresponds to the
ancestral state, since it was found in CRYGD of a lower primate and all the surveyed
nonprimate mammals. Crystallin proteins include two structurally similar domains,
and substitutions in mammalian CRYGD protein at site 23 of the first domain were
always associated with substitutions in the structurally reciprocal sites 109
and 136 of the second domain. These data suggest that the cataractogenic effect
of serine at site 23 in the N-terminal domain of CRYGD may be compensated indirectly
by amino acid changes in a distal domain. We also found that gene conversion was
a factor in the evolution of the γ-crystallin gene cluster throughout different
mammalian clades. The high rate of gene conversion observed between the functional
CRYGD gene and two primate γ-crystallin pseudogenes (CRYGEP1 and CRYGFP1) coupled
with a surprising finding of apparent negative selection in primate pseudogenes
suggest a deleterious impact of recently derived pseudogenes involved in gene
conversion in the γ-crystallin gene cluster.
acknowledgement: This study was supported by the Biodiversity and Dynamics of Gene
Pools program of the Presidium of the Russian Academy of Sciences (support to E.I.R.).
E.I.R. is also supported in part by the National Institute of Diabetes and Digestive
and Kidney Diseases and National Institute of Neurological Disorders and Stroke
(National Institutes of Health), and F.A.K. is supported by a National Science Foundation
graduate research fellowship.
author:
- first_name: Olga
full_name: Plotnikova, Olga V
last_name: Plotnikova
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Peter
full_name: Vlasov, Peter K
last_name: Vlasov
- first_name: Anastasia
full_name: Grigorenko, Anastasia P
last_name: Grigorenko
- first_name: Evgeny
full_name: Ginter, Evgeny K
last_name: Ginter
- first_name: Evgeny
full_name: Rogaev, Evgeny I
last_name: Rogaev
citation:
ama: Plotnikova O, Kondrashov F, Vlasov P, Grigorenko A, Ginter E, Rogaev E. Conversion
and compensatory evolution of the γ-crystallin genes and identification of a cataractogenic
mutation that reverses the sequence of the human CRYGD gene to an ancestral state.
American Journal of Human Genetics. 2007;81(1):32-43. doi:10.1086/518616
apa: Plotnikova, O., Kondrashov, F., Vlasov, P., Grigorenko, A., Ginter, E., &
Rogaev, E. (2007). Conversion and compensatory evolution of the γ-crystallin genes
and identification of a cataractogenic mutation that reverses the sequence of
the human CRYGD gene to an ancestral state. American Journal of Human Genetics.
Cell Press. https://doi.org/10.1086/518616
chicago: Plotnikova, Olga, Fyodor Kondrashov, Peter Vlasov, Anastasia Grigorenko,
Evgeny Ginter, and Evgeny Rogaev. “Conversion and Compensatory Evolution of the
γ-Crystallin Genes and Identification of a Cataractogenic Mutation That Reverses
the Sequence of the Human CRYGD Gene to an Ancestral State.” American Journal
of Human Genetics. Cell Press, 2007. https://doi.org/10.1086/518616.
ieee: O. Plotnikova, F. Kondrashov, P. Vlasov, A. Grigorenko, E. Ginter, and E.
Rogaev, “Conversion and compensatory evolution of the γ-crystallin genes and identification
of a cataractogenic mutation that reverses the sequence of the human CRYGD gene
to an ancestral state,” American Journal of Human Genetics, vol. 81, no.
1. Cell Press, pp. 32–43, 2007.
ista: Plotnikova O, Kondrashov F, Vlasov P, Grigorenko A, Ginter E, Rogaev E. 2007.
Conversion and compensatory evolution of the γ-crystallin genes and identification
of a cataractogenic mutation that reverses the sequence of the human CRYGD gene
to an ancestral state. American Journal of Human Genetics. 81(1), 32–43.
mla: Plotnikova, Olga, et al. “Conversion and Compensatory Evolution of the γ-Crystallin
Genes and Identification of a Cataractogenic Mutation That Reverses the Sequence
of the Human CRYGD Gene to an Ancestral State.” American Journal of Human Genetics,
vol. 81, no. 1, Cell Press, 2007, pp. 32–43, doi:10.1086/518616.
short: O. Plotnikova, F. Kondrashov, P. Vlasov, A. Grigorenko, E. Ginter, E. Rogaev,
American Journal of Human Genetics 81 (2007) 32–43.
date_created: 2018-12-11T11:48:53Z
date_published: 2007-07-01T00:00:00Z
date_updated: 2021-01-12T08:20:14Z
day: '01'
doi: 10.1086/518616
extern: 1
intvolume: ' 81'
issue: '1'
month: '07'
page: 32 - 43
publication: American Journal of Human Genetics
publication_status: published
publisher: Cell Press
publist_id: '6788'
quality_controlled: 0
status: public
title: Conversion and compensatory evolution of the γ-crystallin genes and identification
of a cataractogenic mutation that reverses the sequence of the human CRYGD gene
to an ancestral state
type: journal_article
volume: 81
year: '2007'
...
---
_id: '861'
abstract:
- lang: eng
text: 'Background: Mitochondrial tRNAs have been the subject of study for structural
biologists interested in their secondary structure characteristics, evolutionary
biologists have researched patterns of compensatory and structural evolution and
medical studies have been directed towards understanding the basis of human disease.
However, an up to date, manually curated database of mitochondrially encoded tRNAs
from higher animals is currently not available. Description: We obtained the complete
mitochondrial sequence for 277 tetrapod species from GenBank and re-annotated
all of the tRNAs based on a multiple alignment of each tRNA gene and secondary
structure prediction made independently for each tRNA. The mitochondrial (mt)
tRNA sequences and the secondary structure based multiple alignments are freely
available as Supplemental Information online. Conclusion: We compiled a manually
curated database of mitochondrially encoded tRNAs from tetrapods with completely
sequenced genomes. In the course of our work, we reannotated more than 10% of
all tetrapod mt-tRNAs and subsequently predicted the secondary structures of 6060
mitochondrial tRNAs. This carefully constructed database can be utilized to enhance
our knowledge in several different fields including the evolution of mt-tRNA secondary
structure and prediction of pathogenic mt-tRNA mutations. In addition, researchers
reporting novel mitochondrial genome sequences should check their tRNA gene annotations
against our database to ensure a higher level of fidelity of their annotation.'
acknowledgement: KYuP and LAM were supported by the Molecular and Cellular Biology
Program of the Russian Academy of Science. KYuP was supported by the Russian Fund
of Basic Research (grant 04-04-49623). LAM was partially supported by grants from
the Howard Hughes Medical Institute (55005610), INTAS (05-1000008-8028). FAK is
a National Science Foundation Graduate Research Fellow.
author:
- first_name: Konstantin
full_name: Popadin, Konstantin Yu
last_name: Popadin
- first_name: Leila
full_name: Mamirova, Leila A
last_name: Mamirova
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Popadin K, Mamirova L, Kondrashov F. A manually curated database of tetrapod
mitochondrially encoded tRNA sequences and secondary structures. BMC Bioinformatics.
2007;8. doi:10.1186/1471-2105-8-441
apa: Popadin, K., Mamirova, L., & Kondrashov, F. (2007). A manually curated
database of tetrapod mitochondrially encoded tRNA sequences and secondary structures.
BMC Bioinformatics. BioMed Central. https://doi.org/10.1186/1471-2105-8-441
chicago: Popadin, Konstantin, Leila Mamirova, and Fyodor Kondrashov. “A Manually
Curated Database of Tetrapod Mitochondrially Encoded TRNA Sequences and Secondary
Structures.” BMC Bioinformatics. BioMed Central, 2007. https://doi.org/10.1186/1471-2105-8-441.
ieee: K. Popadin, L. Mamirova, and F. Kondrashov, “A manually curated database of
tetrapod mitochondrially encoded tRNA sequences and secondary structures,” BMC
Bioinformatics, vol. 8. BioMed Central, 2007.
ista: Popadin K, Mamirova L, Kondrashov F. 2007. A manually curated database of
tetrapod mitochondrially encoded tRNA sequences and secondary structures. BMC
Bioinformatics. 8.
mla: Popadin, Konstantin, et al. “A Manually Curated Database of Tetrapod Mitochondrially
Encoded TRNA Sequences and Secondary Structures.” BMC Bioinformatics, vol.
8, BioMed Central, 2007, doi:10.1186/1471-2105-8-441.
short: K. Popadin, L. Mamirova, F. Kondrashov, BMC Bioinformatics 8 (2007).
date_created: 2018-12-11T11:48:54Z
date_published: 2007-11-14T00:00:00Z
date_updated: 2021-01-12T08:20:18Z
day: '14'
doi: 10.1186/1471-2105-8-441
extern: 1
intvolume: ' 8'
month: '11'
publication: BMC Bioinformatics
publication_status: published
publisher: BioMed Central
publist_id: '6789'
quality_controlled: 0
status: public
title: A manually curated database of tetrapod mitochondrially encoded tRNA sequences
and secondary structures
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 8
year: '2007'
...
---
_id: '879'
abstract:
- lang: eng
text: Having an extra copy of a gene is thought to provide some functional redundancy,
which results in a higher rate of evolution in duplicated genes. In this article,
we estimate the impact of gene duplication on the selection of tuf paralogs, and
we find that in the absence of gene conversion, tuf paralogs have evolved significantly
slower than when gene conversion has been a factor in their evolution. Thus, tuf
gene copies evolve under a selective pressure that ensures their functional uniformity,
and gene conversion reduces selection against amino acid substitutions that affect
the function of the encoded protein, EF-Tu.
acknowledgement: We thank Peter Andolfatto, Doris Bachtrog, Robert Cutler, Hideki
Innan, Eugene Koonin, Alexey Kondrashov and Martin Lercher for comments on the manuscript
and for discussions on the interplay between gene conversion and selection. This
work was supported by a National Science Foundation Graduate Research Fellowship
(F.A.K.) and a Molecular and Cellular Biology RAS (Program No 10) grant (P.K.V.).
author:
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Tatiana
full_name: Gurbich, Tatiana A
last_name: Gurbich
- first_name: Peter
full_name: Vlasov, Peter K
last_name: Vlasov
citation:
ama: Kondrashov F, Gurbich T, Vlasov P. Selection for functional uniformity of tuf
duplicates in γ-proteobacteria. Trends in Genetics. 2007;23(5):215-218.
doi:10.1016/j.tig.2007.03.002
apa: Kondrashov, F., Gurbich, T., & Vlasov, P. (2007). Selection for functional
uniformity of tuf duplicates in γ-proteobacteria. Trends in Genetics. Elsevier.
https://doi.org/10.1016/j.tig.2007.03.002
chicago: Kondrashov, Fyodor, Tatiana Gurbich, and Peter Vlasov. “Selection for Functional
Uniformity of Tuf Duplicates in γ-Proteobacteria.” Trends in Genetics.
Elsevier, 2007. https://doi.org/10.1016/j.tig.2007.03.002.
ieee: F. Kondrashov, T. Gurbich, and P. Vlasov, “Selection for functional uniformity
of tuf duplicates in γ-proteobacteria,” Trends in Genetics, vol. 23, no.
5. Elsevier, pp. 215–218, 2007.
ista: Kondrashov F, Gurbich T, Vlasov P. 2007. Selection for functional uniformity
of tuf duplicates in γ-proteobacteria. Trends in Genetics. 23(5), 215–218.
mla: Kondrashov, Fyodor, et al. “Selection for Functional Uniformity of Tuf Duplicates
in γ-Proteobacteria.” Trends in Genetics, vol. 23, no. 5, Elsevier, 2007,
pp. 215–18, doi:10.1016/j.tig.2007.03.002.
short: F. Kondrashov, T. Gurbich, P. Vlasov, Trends in Genetics 23 (2007) 215–218.
date_created: 2018-12-11T11:48:59Z
date_published: 2007-05-01T00:00:00Z
date_updated: 2021-01-12T08:21:04Z
day: '01'
doi: 10.1016/j.tig.2007.03.002
extern: 1
intvolume: ' 23'
issue: '5'
month: '05'
page: 215 - 218
publication: Trends in Genetics
publication_status: published
publisher: Elsevier
publist_id: '6771'
quality_controlled: 0
status: public
title: Selection for functional uniformity of tuf duplicates in γ-proteobacteria
type: journal_article
volume: 23
year: '2007'
...
---
_id: '904'
abstract:
- lang: eng
text: 'Background: Independently evolving lineages mostly accumulate different changes,
which leads to their gradual divergence. However, parallel accumulation of identical
changes is also common, especially in traits with only a small number of possible
states. Results: We characterize parallelism in evolution of coding sequences
in three four-species sets of genomes of mammals, Drosophila, and yeasts. Each
such set contains two independent evolutionary paths, which we call paths I and
II. An amino acid replacement which occurred along path I also occurs along path
II with the probability 50-8211;80% of that expected under selective neutrality.
Thus, the per site rate of parallel evolution of proteins is several times higher
than their average rate of evolution, but still lower than the rate of evolution
of neutral sequences. This deficit may be caused by changes in the fitness landscape,
leading to a replacement being possible along path I but not along path II. However,
constant, weak selection assumed by the nearly neutral model of evolution appears
to be a more likely explanation. Then, the average coefficient of selection associated
with an amino acid replacement, in the units of the effective population size,
must exceed ∼0.4, and the fraction of effectively neutral replacements must be
below ∼30%. At a majority of evolvable amino acid sites, only a relatively small
number of different amino acids is permitted. Conclusion: High, but below-neutral,
rates of parallel amino acid replacements suggest that a majority of amino acid
replacements that occur in evolution are subject to weak, but non-trivial, selection,
as predicted by Ohta''s nearly-neutral theory.'
acknowledgement: G.A.B. gratefully acknowledges fellowships from the Pew Charitable
Trusts award 2000-002558 and the Burroughs Wellcome Fund award 1001782, both to
Princeton University. F.A.K. is a National Science Foundation Graduate Fellow. M.B.'s
work is partially supported by the NSERC Discovery grant. I.D. and A.P. were partially
supported by grant HL066681 (L.A.P., I.D. and S.M.), Berkeley-PGA, under the Programs
for Genomic Applications, funded by National Heart, Lung, & Blood Institute and
Department of Energy Contract DE-AC02-05CH11231, University of California. This
work was partially supported through the Molecular and Cellular Biology Program
of the Russian Academy of Sciences.
author:
- first_name: Georgii
full_name: Bazykin, Georgii A
last_name: Bazykin
- first_name: Fyodor
full_name: Fyodor Kondrashov
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Michael
full_name: Brudno, Michael
last_name: Brudno
- first_name: Alexander
full_name: Poliakov, Alexander V
last_name: Poliakov
- first_name: Inna
full_name: Dubchak, Inna L
last_name: Dubchak
- first_name: Alexey
full_name: Kondrashov, Alexey S
last_name: Kondrashov
citation:
ama: Bazykin G, Kondrashov F, Brudno M, Poliakov A, Dubchak I, Kondrashov A. Extensive
parallelism in protein evolution. Biology Direct. 2007;2. doi:10.1186/1745-6150-2-20
apa: Bazykin, G., Kondrashov, F., Brudno, M., Poliakov, A., Dubchak, I., & Kondrashov,
A. (2007). Extensive parallelism in protein evolution. Biology Direct.
BioMed Central. https://doi.org/10.1186/1745-6150-2-20
chicago: Bazykin, Georgii, Fyodor Kondrashov, Michael Brudno, Alexander Poliakov,
Inna Dubchak, and Alexey Kondrashov. “Extensive Parallelism in Protein Evolution.”
Biology Direct. BioMed Central, 2007. https://doi.org/10.1186/1745-6150-2-20.
ieee: G. Bazykin, F. Kondrashov, M. Brudno, A. Poliakov, I. Dubchak, and A. Kondrashov,
“Extensive parallelism in protein evolution,” Biology Direct, vol. 2. BioMed
Central, 2007.
ista: Bazykin G, Kondrashov F, Brudno M, Poliakov A, Dubchak I, Kondrashov A. 2007.
Extensive parallelism in protein evolution. Biology Direct. 2.
mla: Bazykin, Georgii, et al. “Extensive Parallelism in Protein Evolution.” Biology
Direct, vol. 2, BioMed Central, 2007, doi:10.1186/1745-6150-2-20.
short: G. Bazykin, F. Kondrashov, M. Brudno, A. Poliakov, I. Dubchak, A. Kondrashov,
Biology Direct 2 (2007).
date_created: 2018-12-11T11:49:07Z
date_published: 2007-08-16T00:00:00Z
date_updated: 2021-01-12T08:21:47Z
day: '16'
doi: 10.1186/1745-6150-2-20
extern: 1
intvolume: ' 2'
month: '08'
publication: Biology Direct
publication_status: published
publisher: BioMed Central
publist_id: '6745'
quality_controlled: 0
status: public
title: Extensive parallelism in protein evolution
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 2
year: '2007'
...
---
_id: '9149'
abstract:
- lang: eng
text: "The interaction of tidal currents with sea-floor topography results in the
radiation of internal gravity waves into the ocean interior. These waves are called
internal tides and their dissipation due to nonlinear wave breaking and concomitant
three-dimensional turbulence could play an important role in the mixing of the
abyssal ocean, and hence in controlling the large-scale ocean circulation.\r\nAs
part of on-going work aimed at providing a theory for the vertical distribution
of wave breaking over sea-floor topography, in this paper we investigate the instability
of internal tides in a very simple linear model that helps us to relate the formation
of unstable regions to simple features in the sea-floor topography. For two-dimensional
tides over one-dimensional topography we find that the formation of overturning
instabilities is closely linked to the singularities in the topography shape and
that it is possible to have stable waves at the sea floor and unstable waves in
the ocean interior above.\r\nFor three-dimensional tides over two-dimensional
topography there is in addition an effect of geometric focusing of wave energy
into localized regions of high wave amplitude, and we investigate this focusing
effect in simple examples. Overall, we find that the distribution of unstable
wave breaking regions can be highly non-uniform even for very simple idealized
topography shapes."
article_processing_charge: No
article_type: original
author:
- first_name: Oliver
full_name: Bühler, Oliver
last_name: Bühler
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
citation:
ama: Bühler O, Muller CJ. Instability and focusing of internal tides in the deep
ocean. Journal of Fluid Mechanics. 2007;588:1-28. doi:10.1017/s0022112007007410
apa: Bühler, O., & Muller, C. J. (2007). Instability and focusing of internal
tides in the deep ocean. Journal of Fluid Mechanics. Cambridge University
Press. https://doi.org/10.1017/s0022112007007410
chicago: Bühler, Oliver, and Caroline J Muller. “Instability and Focusing of Internal
Tides in the Deep Ocean.” Journal of Fluid Mechanics. Cambridge University
Press, 2007. https://doi.org/10.1017/s0022112007007410.
ieee: O. Bühler and C. J. Muller, “Instability and focusing of internal tides in
the deep ocean,” Journal of Fluid Mechanics, vol. 588. Cambridge University
Press, pp. 1–28, 2007.
ista: Bühler O, Muller CJ. 2007. Instability and focusing of internal tides in the
deep ocean. Journal of Fluid Mechanics. 588, 1–28.
mla: Bühler, Oliver, and Caroline J. Muller. “Instability and Focusing of Internal
Tides in the Deep Ocean.” Journal of Fluid Mechanics, vol. 588, Cambridge
University Press, 2007, pp. 1–28, doi:10.1017/s0022112007007410.
short: O. Bühler, C.J. Muller, Journal of Fluid Mechanics 588 (2007) 1–28.
date_created: 2021-02-15T14:41:45Z
date_published: 2007-10-10T00:00:00Z
date_updated: 2022-01-24T13:43:36Z
day: '10'
doi: 10.1017/s0022112007007410
extern: '1'
intvolume: ' 588'
keyword:
- mechanical engineering
- mechanics of materials
- condensed matter physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1017/S0022112007007410
month: '10'
oa: 1
oa_version: None
page: 1-28
publication: Journal of Fluid Mechanics
publication_identifier:
issn:
- 0022-1120
- 1469-7645
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: Instability and focusing of internal tides in the deep ocean
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 588
year: '2007'
...
---
_id: '7323'
abstract:
- lang: eng
text: The main factors for reducing the consumption of a vehicle are reduction of
curb weight, air drag and increase in the drivetrain efficiency. Highly efficient
drivetrains can be developed based on PEFC technology and curb weight may be limited
by an innovative vehicle construction. In this paper, data on consumption and
efficiency of a four‐place passenger vehicle with a curb weight of 850 kg and
an H2/O2 fed PEFC/Supercap hybrid electric powertrain are presented. Hydrogen
consumption in the New European Driving Cycle is 0.67 kg H2/100 km, which corresponds
to a gasoline equivalent consumption of 2.5 l/100 km. When including the energy
needed to supply pure oxygen, the calculated consumption increases from 0.67 to
0.69–0.79 kg H2/100 km, depending on the method of oxygen production.
article_processing_charge: No
article_type: original
author:
- first_name: F. N.
full_name: Büchi, F. N.
last_name: Büchi
- first_name: G.
full_name: Paganelli, G.
last_name: Paganelli
- first_name: P.
full_name: Dietrich, P.
last_name: Dietrich
- first_name: D.
full_name: Laurent, D.
last_name: Laurent
- first_name: A.
full_name: Tsukada, A.
last_name: Tsukada
- first_name: P.
full_name: Varenne, P.
last_name: Varenne
- first_name: A.
full_name: Delfino, A.
last_name: Delfino
- first_name: R.
full_name: Kötz, R.
last_name: Kötz
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: P.-A.
full_name: Magne, P.-A.
last_name: Magne
- first_name: D.
full_name: Walser, D.
last_name: Walser
- first_name: D.
full_name: Olsommer, D.
last_name: Olsommer
citation:
ama: Büchi FN, Paganelli G, Dietrich P, et al. Consumption and efficiency of a passenger
car with a Hydrogen/Oxygen PEFC based hybrid electric drivetrain. Fuel Cells.
2007;7(4):329-335. doi:10.1002/fuce.200600050
apa: Büchi, F. N., Paganelli, G., Dietrich, P., Laurent, D., Tsukada, A., Varenne,
P., … Olsommer, D. (2007). Consumption and efficiency of a passenger car with
a Hydrogen/Oxygen PEFC based hybrid electric drivetrain. Fuel Cells. Wiley.
https://doi.org/10.1002/fuce.200600050
chicago: Büchi, F. N., G. Paganelli, P. Dietrich, D. Laurent, A. Tsukada, P. Varenne,
A. Delfino, et al. “Consumption and Efficiency of a Passenger Car with a Hydrogen/Oxygen
PEFC Based Hybrid Electric Drivetrain.” Fuel Cells. Wiley, 2007. https://doi.org/10.1002/fuce.200600050.
ieee: F. N. Büchi et al., “Consumption and efficiency of a passenger car
with a Hydrogen/Oxygen PEFC based hybrid electric drivetrain,” Fuel Cells,
vol. 7, no. 4. Wiley, pp. 329–335, 2007.
ista: Büchi FN, Paganelli G, Dietrich P, Laurent D, Tsukada A, Varenne P, Delfino
A, Kötz R, Freunberger SA, Magne P-A, Walser D, Olsommer D. 2007. Consumption
and efficiency of a passenger car with a Hydrogen/Oxygen PEFC based hybrid electric
drivetrain. Fuel Cells. 7(4), 329–335.
mla: Büchi, F. N., et al. “Consumption and Efficiency of a Passenger Car with a
Hydrogen/Oxygen PEFC Based Hybrid Electric Drivetrain.” Fuel Cells, vol.
7, no. 4, Wiley, 2007, pp. 329–35, doi:10.1002/fuce.200600050.
short: F.N. Büchi, G. Paganelli, P. Dietrich, D. Laurent, A. Tsukada, P. Varenne,
A. Delfino, R. Kötz, S.A. Freunberger, P.-A. Magne, D. Walser, D. Olsommer, Fuel
Cells 7 (2007) 329–335.
date_created: 2020-01-15T12:22:10Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2021-01-12T08:13:04Z
day: '01'
doi: 10.1002/fuce.200600050
extern: '1'
intvolume: ' 7'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 329-335
publication: Fuel Cells
publication_identifier:
issn:
- 1615-6846
- 1615-6854
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Consumption and efficiency of a passenger car with a Hydrogen/Oxygen PEFC based
hybrid electric drivetrain
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2007'
...
---
_id: '7324'
abstract:
- lang: eng
text: Efficiency is the key parameter for the application of fuel cells in automotive
applications. The efficiency of a hydrogen/oxygen polymer electrolyte fuel cell
system is analyzed and compared to hydrogen/air systems. The analysis is performed
for the tank to electric power chain. Furthermore, the additional energy required
for using pure oxygen as a second fuel is analyzed and included in the calculation.
The results show that if hydrogen is produced from primary fossil energy carriers,
such as natural gas and pure oxygen needs to be obtained by a conventional process;
the fuel to electric current efficiency is comparable for hydrogen/oxygen and
hydrogen/air systems. However, if hydrogen and oxygen are produced by the splitting
of water, i.e., by electrolysis or by a thermochemical process, the fuel to electric
current efficiency for the hydrogen/oxygen system is clearly superior.
article_processing_charge: No
article_type: original
author:
- first_name: F. N.
full_name: Büchi, F. N.
last_name: Büchi
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: M.
full_name: Reum, M.
last_name: Reum
- first_name: G.
full_name: Paganelli, G.
last_name: Paganelli
- first_name: A.
full_name: Tsukada, A.
last_name: Tsukada
- first_name: P.
full_name: Dietrich, P.
last_name: Dietrich
- first_name: A.
full_name: Delfino, A.
last_name: Delfino
citation:
ama: Büchi FN, Freunberger SA, Reum M, et al. On the efficiency of an advanced automotive
fuel cell system. Fuel Cells. 2007;7(2):159-164. doi:10.1002/fuce.200500257
apa: Büchi, F. N., Freunberger, S. A., Reum, M., Paganelli, G., Tsukada, A., Dietrich,
P., & Delfino, A. (2007). On the efficiency of an advanced automotive fuel
cell system. Fuel Cells. Wiley. https://doi.org/10.1002/fuce.200500257
chicago: Büchi, F. N., Stefan Alexander Freunberger, M. Reum, G. Paganelli, A. Tsukada,
P. Dietrich, and A. Delfino. “On the Efficiency of an Advanced Automotive Fuel
Cell System.” Fuel Cells. Wiley, 2007. https://doi.org/10.1002/fuce.200500257.
ieee: F. N. Büchi et al., “On the efficiency of an advanced automotive fuel
cell system,” Fuel Cells, vol. 7, no. 2. Wiley, pp. 159–164, 2007.
ista: Büchi FN, Freunberger SA, Reum M, Paganelli G, Tsukada A, Dietrich P, Delfino
A. 2007. On the efficiency of an advanced automotive fuel cell system. Fuel Cells.
7(2), 159–164.
mla: Büchi, F. N., et al. “On the Efficiency of an Advanced Automotive Fuel Cell
System.” Fuel Cells, vol. 7, no. 2, Wiley, 2007, pp. 159–64, doi:10.1002/fuce.200500257.
short: F.N. Büchi, S.A. Freunberger, M. Reum, G. Paganelli, A. Tsukada, P. Dietrich,
A. Delfino, Fuel Cells 7 (2007) 159–164.
date_created: 2020-01-15T12:22:20Z
date_published: 2007-04-01T00:00:00Z
date_updated: 2021-01-12T08:13:04Z
day: '01'
doi: 10.1002/fuce.200500257
extern: '1'
intvolume: ' 7'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 159-164
publication: Fuel Cells
publication_identifier:
issn:
- 1615-6846
- 1615-6854
publication_status: published
publisher: Wiley
status: public
title: On the efficiency of an advanced automotive fuel cell system
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2007'
...
---
_id: '7325'
abstract:
- lang: eng
text: Our experimental results shown here disprove that finite diffusion can generally
be assumed in ac impedance models for H2/air-polymer electrolyte fuel cells (PEFCs)
to account for the diffusive transport of oxygen through the gas diffusion layer
(GDL) toward the air electrode. It is shown that the amplitude of the oxygen concentration
oscillation created as a consequence of superimposed ac current at the air electrode
is not zero at the channel/GDL interface but extends into the gas channels, at
least below modulation frequencies of fmod=10 Hz . By this, sinusoidal oxygen-concentration
oscillations within the cathode gas channels are excited locally along the flow
field. Due to the forced air convection in the cathode flow-field channels, a
coupling via the gas phase occurs downstream of the flow field. The coupling strongly
affects the local and by this the overall impedance response of the cell and evokes
the formation of a low-frequency arc in H2/air-PEFC impedance spectra. Based on
the experimental results, a qualitative model is presented explaining the local
impedance response of a segmented 200cm2H2/air PEFC.
article_number: B383
article_processing_charge: No
article_type: original
author:
- first_name: I. A.
full_name: Schneider, I. A.
last_name: Schneider
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: D.
full_name: Kramer, D.
last_name: Kramer
- first_name: A.
full_name: Wokaun, A.
last_name: Wokaun
- first_name: G. G.
full_name: Scherer, G. G.
last_name: Scherer
citation:
ama: 'Schneider IA, Freunberger SA, Kramer D, Wokaun A, Scherer GG. Oscillations
in gas channels: Part I. The forgotten player in impedance spectroscopy in PEFCs.
Journal of The Electrochemical Society. 2007;154(4). doi:10.1149/1.2435706'
apa: 'Schneider, I. A., Freunberger, S. A., Kramer, D., Wokaun, A., & Scherer,
G. G. (2007). Oscillations in gas channels: Part I. The forgotten player in impedance
spectroscopy in PEFCs. Journal of The Electrochemical Society. The Electrochemical
Society. https://doi.org/10.1149/1.2435706'
chicago: 'Schneider, I. A., Stefan Alexander Freunberger, D. Kramer, A. Wokaun,
and G. G. Scherer. “Oscillations in Gas Channels: Part I. The Forgotten Player
in Impedance Spectroscopy in PEFCs.” Journal of The Electrochemical Society.
The Electrochemical Society, 2007. https://doi.org/10.1149/1.2435706.'
ieee: 'I. A. Schneider, S. A. Freunberger, D. Kramer, A. Wokaun, and G. G. Scherer,
“Oscillations in gas channels: Part I. The forgotten player in impedance spectroscopy
in PEFCs,” Journal of The Electrochemical Society, vol. 154, no. 4. The
Electrochemical Society, 2007.'
ista: 'Schneider IA, Freunberger SA, Kramer D, Wokaun A, Scherer GG. 2007. Oscillations
in gas channels: Part I. The forgotten player in impedance spectroscopy in PEFCs.
Journal of The Electrochemical Society. 154(4), B383.'
mla: 'Schneider, I. A., et al. “Oscillations in Gas Channels: Part I. The Forgotten
Player in Impedance Spectroscopy in PEFCs.” Journal of The Electrochemical
Society, vol. 154, no. 4, B383, The Electrochemical Society, 2007, doi:10.1149/1.2435706.'
short: I.A. Schneider, S.A. Freunberger, D. Kramer, A. Wokaun, G.G. Scherer, Journal
of The Electrochemical Society 154 (2007).
date_created: 2020-01-15T12:22:31Z
date_published: 2007-02-09T00:00:00Z
date_updated: 2021-01-12T08:13:05Z
day: '09'
doi: 10.1149/1.2435706
extern: '1'
intvolume: ' 154'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
publication: Journal of The Electrochemical Society
publication_identifier:
issn:
- 0013-4651
publication_status: published
publisher: The Electrochemical Society
quality_controlled: '1'
status: public
title: 'Oscillations in gas channels: Part I. The forgotten player in impedance spectroscopy
in PEFCs'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 154
year: '2007'
...
---
_id: '7704'
abstract:
- lang: eng
text: Gradients of axon guidance molecules instruct the formation of continuous
neural maps, such as the retinotopic map in the vertebrate visual system. Here
we show that molecular gradients can also instruct the formation of a discrete
neural map. In the fly olfactory system, axons of 50 classes of olfactory receptor
neurons (ORNs) and dendrites of 50 classes of projection neurons (PNs) form one-to-one
connections at discrete units called glomeruli. We provide expression, loss- and
gain-of-function data to demonstrate that the levels of transmembrane Semaphorin-1a
(Sema-1a), acting cell-autonomously as a receptor or part of a receptor complex,
direct the dendritic targeting of PNs along the dorsolateral to ventromedial axis
of the antennal lobe. Sema-1a also regulates PN axon targeting in higher olfactory
centers. Thus, graded expression of Sema-1a contributes to connection specificity
from ORNs to PNs and then to higher brain centers, ensuring proper representation
of olfactory information in the brain.
article_processing_charge: No
article_type: original
author:
- first_name: Takaki
full_name: Komiyama, Takaki
last_name: Komiyama
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Oren
full_name: Schuldiner, Oren
last_name: Schuldiner
- first_name: K. Christopher
full_name: Garcia, K. Christopher
last_name: Garcia
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Komiyama T, Sweeney LB, Schuldiner O, Garcia KC, Luo L. Graded expression of
semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection
neurons. Cell. 2007;128(2):399-410. doi:10.1016/j.cell.2006.12.028
apa: Komiyama, T., Sweeney, L. B., Schuldiner, O., Garcia, K. C., & Luo, L.
(2007). Graded expression of semaphorin-1a cell-autonomously directs dendritic
targeting of olfactory projection neurons. Cell. Elsevier. https://doi.org/10.1016/j.cell.2006.12.028
chicago: Komiyama, Takaki, Lora B. Sweeney, Oren Schuldiner, K. Christopher Garcia,
and Liqun Luo. “Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic
Targeting of Olfactory Projection Neurons.” Cell. Elsevier, 2007. https://doi.org/10.1016/j.cell.2006.12.028.
ieee: T. Komiyama, L. B. Sweeney, O. Schuldiner, K. C. Garcia, and L. Luo, “Graded
expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory
projection neurons,” Cell, vol. 128, no. 2. Elsevier, pp. 399–410, 2007.
ista: Komiyama T, Sweeney LB, Schuldiner O, Garcia KC, Luo L. 2007. Graded expression
of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection
neurons. Cell. 128(2), 399–410.
mla: Komiyama, Takaki, et al. “Graded Expression of Semaphorin-1a Cell-Autonomously
Directs Dendritic Targeting of Olfactory Projection Neurons.” Cell, vol.
128, no. 2, Elsevier, 2007, pp. 399–410, doi:10.1016/j.cell.2006.12.028.
short: T. Komiyama, L.B. Sweeney, O. Schuldiner, K.C. Garcia, L. Luo, Cell 128 (2007)
399–410.
date_created: 2020-04-30T10:37:08Z
date_published: 2007-01-26T00:00:00Z
date_updated: 2024-01-31T10:14:48Z
day: '26'
doi: 10.1016/j.cell.2006.12.028
extern: '1'
intvolume: ' 128'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 399-410
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting
of olfactory projection neurons
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2007'
...
---
_id: '7705'
abstract:
- lang: eng
text: Axon-axon interactions have been implicated in neural circuit assembly, but
the underlying mechanisms are poorly understood. Here, we show that in the Drosophila
antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from
the antenna are required for the proper targeting of late-arriving ORN axons from
the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but
only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to
control ORN axon-axon interactions, in contrast to its cell-autonomous function
in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate
PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons
is required for correct targeting of MP axons within the antennal lobe, while
interactions amongst MP axons facilitate their entry into the antennal lobe. We
propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which
early-arriving ORN axons constrain the target choices of late-arriving axons.
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Africa
full_name: Couto, Africa
last_name: Couto
- first_name: Ya-Hui
full_name: Chou, Ya-Hui
last_name: Chou
- first_name: Daniela
full_name: Berdnik, Daniela
last_name: Berdnik
- first_name: Barry J.
full_name: Dickson, Barry J.
last_name: Dickson
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
- first_name: Takaki
full_name: Komiyama, Takaki
last_name: Komiyama
citation:
ama: Sweeney LB, Couto A, Chou Y-H, et al. Temporal target restriction of olfactory
receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron.
2007;53(2):185-200. doi:10.1016/j.neuron.2006.12.022
apa: Sweeney, L. B., Couto, A., Chou, Y.-H., Berdnik, D., Dickson, B. J., Luo, L.,
& Komiyama, T. (2007). Temporal target restriction of olfactory receptor neurons
by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2006.12.022
chicago: Sweeney, Lora B., Africa Couto, Ya-Hui Chou, Daniela Berdnik, Barry J.
Dickson, Liqun Luo, and Takaki Komiyama. “Temporal Target Restriction of Olfactory
Receptor Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron.
Elsevier, 2007. https://doi.org/10.1016/j.neuron.2006.12.022.
ieee: L. B. Sweeney et al., “Temporal target restriction of olfactory receptor
neurons by semaphorin-1a/plexinA-mediated axon-axon interactions,” Neuron,
vol. 53, no. 2. Elsevier, pp. 185–200, 2007.
ista: Sweeney LB, Couto A, Chou Y-H, Berdnik D, Dickson BJ, Luo L, Komiyama T. 2007.
Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated
axon-axon interactions. Neuron. 53(2), 185–200.
mla: Sweeney, Lora B., et al. “Temporal Target Restriction of Olfactory Receptor
Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron,
vol. 53, no. 2, Elsevier, 2007, pp. 185–200, doi:10.1016/j.neuron.2006.12.022.
short: L.B. Sweeney, A. Couto, Y.-H. Chou, D. Berdnik, B.J. Dickson, L. Luo, T.
Komiyama, Neuron 53 (2007) 185–200.
date_created: 2020-04-30T10:37:24Z
date_published: 2007-01-18T00:00:00Z
date_updated: 2024-01-31T10:14:39Z
day: '18'
doi: 10.1016/j.neuron.2006.12.022
extern: '1'
intvolume: ' 53'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 185-200
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated
axon-axon interactions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2007'
...
---
_id: '7753'
abstract:
- lang: eng
text: 'In many species, females show reduced expression of a trait that is under
sexual selection in males, and this expression is thought to be maintained through
genetic associations with the male phenotype. However, there is also the potential
for the female trait to convey an advantage in intrasexual conflicts over resources.
We tested this hypothesis in a feral population of Soay sheep, in which males
and females have a polymorphism for horn development, producing either full (normal
horned), reduced (scurred) or no (polled, females only) horns. During the lambing
period, females who possessed horns were more likely to initiate and win aggressive
interactions, independent of age, weight and birthing status. The occurrence of
aggression was also context dependent, decreasing over the lambing period and
associated with local density. Our results demonstrate that a trait that confers
benefits to males during intrasexual competition for mates may also be used by
females in intrasexual competition over resources: males use weaponry to gain
mates, whereas females use weaponry to gain food.'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Loeske E.B
full_name: Kruuk, Loeske E.B
last_name: Kruuk
citation:
ama: 'Robinson MR, Kruuk LE. Function of weaponry in females: The use of horns in
intrasexual competition for resources in female Soay sheep. Biology Letters.
2007;3(6):651-654. doi:10.1098/rsbl.2007.0278'
apa: 'Robinson, M. R., & Kruuk, L. E. . (2007). Function of weaponry in females:
The use of horns in intrasexual competition for resources in female Soay sheep.
Biology Letters. The Royal Society. https://doi.org/10.1098/rsbl.2007.0278'
chicago: 'Robinson, Matthew Richard, and Loeske E.B Kruuk. “Function of Weaponry
in Females: The Use of Horns in Intrasexual Competition for Resources in Female
Soay Sheep.” Biology Letters. The Royal Society, 2007. https://doi.org/10.1098/rsbl.2007.0278.'
ieee: 'M. R. Robinson and L. E. . Kruuk, “Function of weaponry in females: The use
of horns in intrasexual competition for resources in female Soay sheep,” Biology
Letters, vol. 3, no. 6. The Royal Society, pp. 651–654, 2007.'
ista: 'Robinson MR, Kruuk LE. 2007. Function of weaponry in females: The use of
horns in intrasexual competition for resources in female Soay sheep. Biology Letters.
3(6), 651–654.'
mla: 'Robinson, Matthew Richard, and Loeske E. .. Kruuk. “Function of Weaponry in
Females: The Use of Horns in Intrasexual Competition for Resources in Female Soay
Sheep.” Biology Letters, vol. 3, no. 6, The Royal Society, 2007, pp. 651–54,
doi:10.1098/rsbl.2007.0278.'
short: M.R. Robinson, L.E.. Kruuk, Biology Letters 3 (2007) 651–654.
date_created: 2020-04-30T11:02:28Z
date_published: 2007-08-21T00:00:00Z
date_updated: 2021-01-12T08:15:18Z
day: '21'
doi: 10.1098/rsbl.2007.0278
extern: '1'
external_id:
pmid:
- '17711817'
intvolume: ' 3'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1098/rsbl.2007.0278
month: '08'
oa: 1
oa_version: Published Version
page: 651-654
pmid: 1
publication: Biology Letters
publication_identifier:
issn:
- 1744-9561
- 1744-957X
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
status: public
title: 'Function of weaponry in females: The use of horns in intrasexual competition
for resources in female Soay sheep'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2007'
...
---
_id: '7780'
abstract:
- lang: eng
text: 'We used single-channel electrical recordings and Langevin molecular dynamics
simulations to explore the electrophoretic translocation of various β-hairpin
peptides across the staphylococcal α-hemolysin (αHL) protein pore at single-molecule
resolution. The β-hairpin peptides, which varied in their folding properties,
corresponded to the C terminal residues of the B1 domain of protein G. The translocation
time was strongly dependent on the electric force and was correlated with the
folding features of the β-hairpin peptides. Highly unfolded peptides entered the
pore in an extended conformation, resulting in fast single-file translocation
events. In contrast, the translocation of the folded β-hairpin peptides occurred
more slowly. In this case, the β-hairpin peptides traversed the αHL pore in a
misfolded or fully folded conformation. This study demonstrates that the interaction
between a polypeptide and a β-barrel protein pore is dependent on the folding
features of the polypeptide. '
article_processing_charge: No
article_type: original
author:
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Serdal
full_name: Kirmizialtin, Serdal
last_name: Kirmizialtin
- first_name: Beatrice M.
full_name: Huyghues-Despointes, Beatrice M.
last_name: Huyghues-Despointes
- first_name: Aiping
full_name: Zhu, Aiping
last_name: Zhu
- first_name: J. Martin
full_name: Scholtz, J. Martin
last_name: Scholtz
- first_name: Dmitrii E.
full_name: Makarov, Dmitrii E.
last_name: Makarov
- first_name: Liviu
full_name: Movileanu, Liviu
last_name: Movileanu
citation:
ama: Goodrich CP, Kirmizialtin S, Huyghues-Despointes BM, et al. Single-molecule
electrophoresis of β-hairpin peptides by electrical recordings and Langevin dynamics
simulations. The Journal of Physical Chemistry B. 2007;111(13):3332-3335.
doi:10.1021/jp071364h
apa: Goodrich, C. P., Kirmizialtin, S., Huyghues-Despointes, B. M., Zhu, A., Scholtz,
J. M., Makarov, D. E., & Movileanu, L. (2007). Single-molecule electrophoresis
of β-hairpin peptides by electrical recordings and Langevin dynamics simulations.
The Journal of Physical Chemistry B. American Chemical Society. https://doi.org/10.1021/jp071364h
chicago: Goodrich, Carl Peter, Serdal Kirmizialtin, Beatrice M. Huyghues-Despointes,
Aiping Zhu, J. Martin Scholtz, Dmitrii E. Makarov, and Liviu Movileanu. “Single-Molecule
Electrophoresis of β-Hairpin Peptides by Electrical Recordings and Langevin Dynamics
Simulations.” The Journal of Physical Chemistry B. American Chemical Society,
2007. https://doi.org/10.1021/jp071364h.
ieee: C. P. Goodrich et al., “Single-molecule electrophoresis of β-hairpin
peptides by electrical recordings and Langevin dynamics simulations,” The Journal
of Physical Chemistry B, vol. 111, no. 13. American Chemical Society, pp.
3332–3335, 2007.
ista: Goodrich CP, Kirmizialtin S, Huyghues-Despointes BM, Zhu A, Scholtz JM, Makarov
DE, Movileanu L. 2007. Single-molecule electrophoresis of β-hairpin peptides by
electrical recordings and Langevin dynamics simulations. The Journal of Physical
Chemistry B. 111(13), 3332–3335.
mla: Goodrich, Carl Peter, et al. “Single-Molecule Electrophoresis of β-Hairpin
Peptides by Electrical Recordings and Langevin Dynamics Simulations.” The Journal
of Physical Chemistry B, vol. 111, no. 13, American Chemical Society, 2007,
pp. 3332–35, doi:10.1021/jp071364h.
short: C.P. Goodrich, S. Kirmizialtin, B.M. Huyghues-Despointes, A. Zhu, J.M. Scholtz,
D.E. Makarov, L. Movileanu, The Journal of Physical Chemistry B 111 (2007) 3332–3335.
date_created: 2020-04-30T12:19:15Z
date_published: 2007-03-13T00:00:00Z
date_updated: 2021-01-12T08:15:29Z
day: '13'
doi: 10.1021/jp071364h
extern: '1'
intvolume: ' 111'
issue: '13'
language:
- iso: eng
month: '03'
oa_version: None
page: 3332-3335
publication: The Journal of Physical Chemistry B
publication_identifier:
issn:
- 1520-6106
- 1520-5207
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Single-molecule electrophoresis of β-hairpin peptides by electrical recordings
and Langevin dynamics simulations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 111
year: '2007'
...