---
_id: '3409'
abstract:
- lang: eng
  text: With the introduction of single-molecule force spectroscopy (SMFS) it has
    become possible to directly access the interactions of various molecular systems.
    A bottleneck in conventional SMFS is collecting the large amount of data required
    for statistically meaningful analysis. Currently, atomic force microscopy (AFM)-based
    SMFS requires the user to tediously 'fish' for single molecules. In addition,
    most experimental and environmental conditions must be manually adjusted. Here,
    we developed a fully automated single-molecule force spectroscope. The instrument
    is able to perform SMFS while monitoring and regulating experimental conditions
    such as buffer composition and temperature. Cantilever alignment and calibration
    can also be automatically performed during experiments. This, combined with in-line
    data analysis, enables the instrument, once set up, to perform complete SMFS experiments
    autonomously.
author:
- first_name: Jens
  full_name: Struckmeier, Jens
  last_name: Struckmeier
- first_name: Reiner
  full_name: Wahl, Reiner
  last_name: Wahl
- first_name: Mirko
  full_name: Leuschner, Mirko
  last_name: Leuschner
- first_name: Joao
  full_name: Nunes, Joao
  last_name: Nunes
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Ulrich
  full_name: Geisler, Ulrich
  last_name: Geisler
- first_name: Gerd
  full_name: Hofmann, Gerd
  last_name: Hofmann
- first_name: Torsten
  full_name: Jähnke, Torsten
  last_name: Jähnke
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
citation:
  ama: Struckmeier J, Wahl R, Leuschner M, et al. Fully automated single-molecule
    force spectroscopy for screening applications. <i>Nanotechnology</i>. 2008;19(38).
    doi:<a href="https://doi.org/10.1088/0957-4484/19/38/384020">10.1088/0957-4484/19/38/384020</a>
  apa: Struckmeier, J., Wahl, R., Leuschner, M., Nunes, J., Janovjak, H. L., Geisler,
    U., … Mueller, D. (2008). Fully automated single-molecule force spectroscopy for
    screening applications. <i>Nanotechnology</i>. IOP Publishing Ltd. <a href="https://doi.org/10.1088/0957-4484/19/38/384020">https://doi.org/10.1088/0957-4484/19/38/384020</a>
  chicago: Struckmeier, Jens, Reiner Wahl, Mirko Leuschner, Joao Nunes, Harald L Janovjak,
    Ulrich Geisler, Gerd Hofmann, Torsten Jähnke, and Daniel Mueller. “Fully Automated
    Single-Molecule Force Spectroscopy for Screening Applications.” <i>Nanotechnology</i>.
    IOP Publishing Ltd., 2008. <a href="https://doi.org/10.1088/0957-4484/19/38/384020">https://doi.org/10.1088/0957-4484/19/38/384020</a>.
  ieee: J. Struckmeier <i>et al.</i>, “Fully automated single-molecule force spectroscopy
    for screening applications,” <i>Nanotechnology</i>, vol. 19, no. 38. IOP Publishing
    Ltd., 2008.
  ista: Struckmeier J, Wahl R, Leuschner M, Nunes J, Janovjak HL, Geisler U, Hofmann
    G, Jähnke T, Mueller D. 2008. Fully automated single-molecule force spectroscopy
    for screening applications. Nanotechnology. 19(38).
  mla: Struckmeier, Jens, et al. “Fully Automated Single-Molecule Force Spectroscopy
    for Screening Applications.” <i>Nanotechnology</i>, vol. 19, no. 38, IOP Publishing
    Ltd., 2008, doi:<a href="https://doi.org/10.1088/0957-4484/19/38/384020">10.1088/0957-4484/19/38/384020</a>.
  short: J. Struckmeier, R. Wahl, M. Leuschner, J. Nunes, H.L. Janovjak, U. Geisler,
    G. Hofmann, T. Jähnke, D. Mueller, Nanotechnology 19 (2008).
date_created: 2018-12-11T12:03:11Z
date_published: 2008-08-12T00:00:00Z
date_updated: 2021-01-12T07:43:17Z
day: '12'
doi: 10.1088/0957-4484/19/38/384020
extern: 1
intvolume: '        19'
issue: '38'
month: '08'
publication: Nanotechnology
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '2993'
quality_controlled: 0
status: public
title: Fully automated single-molecule force spectroscopy for screening applications
type: journal_article
volume: 19
year: '2008'
...
---
_id: '3410'
abstract:
- lang: eng
  text: Membrane proteins are involved in essential biological processes such as energy
    conversion, signal transduction, solute transport and secretion. All biological
    processes, also those involving membrane proteins, are steered by molecular interactions.
    Molecular interactions guide the folding and stability of membrane proteins, determine
    their assembly, switch their functional states or mediate signal transduction.
    The sequential steps of molecular interactions driving these processes can be
    described by dynamic energy landscapes. The conceptual energy landscape allows
    to follow the complex reaction pathways of membrane proteins while its modifications
    describe why and how pathways are changed. Single-molecule force spectroscopy
    (SMFS) detects, quantifies and locates interactions within and between membrane
    proteins. SMFS helps to determine how these interactions change with temperature,
    point mutations, oligomerization and the functional states of membrane proteins.
    Applied in different modes, SMFS explores the co-existence and population of reaction
    pathways in the energy landscape of the protein and thus reveals detailed insights
    into local mechanisms, determining its structural and functional relationships.
    Here we review how SMFS extracts the defining parameters of an energy landscape
    such as the barrier position, reaction kinetics and roughness with high precision.
author:
- first_name: Harald L
  full_name: Harald Janovjak
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Tanuj
  full_name: Sapra, Tanuj K
  last_name: Sapra
- first_name: Alexej
  full_name: Kedrov, Alexej
  last_name: Kedrov
- first_name: Daniel
  full_name: Mueller, Daniel J
  last_name: Mueller
citation:
  ama: 'Janovjak HL, Sapra T, Kedrov A, Mueller D. From valleys to ridges: Exploring
    the energy landscape of single membrane proteins. <i>ChemPhysChem</i>. 2008;9(7):954-966.
    doi:<a href="https://doi.org/10.1002/cphc.200700662">10.1002/cphc.200700662</a>'
  apa: 'Janovjak, H. L., Sapra, T., Kedrov, A., &#38; Mueller, D. (2008). From valleys
    to ridges: Exploring the energy landscape of single membrane proteins. <i>ChemPhysChem</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1002/cphc.200700662">https://doi.org/10.1002/cphc.200700662</a>'
  chicago: 'Janovjak, Harald L, Tanuj Sapra, Alexej Kedrov, and Daniel Mueller. “From
    Valleys to Ridges: Exploring the Energy Landscape of Single Membrane Proteins.”
    <i>ChemPhysChem</i>. Wiley-Blackwell, 2008. <a href="https://doi.org/10.1002/cphc.200700662">https://doi.org/10.1002/cphc.200700662</a>.'
  ieee: 'H. L. Janovjak, T. Sapra, A. Kedrov, and D. Mueller, “From valleys to ridges:
    Exploring the energy landscape of single membrane proteins,” <i>ChemPhysChem</i>,
    vol. 9, no. 7. Wiley-Blackwell, pp. 954–966, 2008.'
  ista: 'Janovjak HL, Sapra T, Kedrov A, Mueller D. 2008. From valleys to ridges:
    Exploring the energy landscape of single membrane proteins. ChemPhysChem. 9(7),
    954–966.'
  mla: 'Janovjak, Harald L., et al. “From Valleys to Ridges: Exploring the Energy
    Landscape of Single Membrane Proteins.” <i>ChemPhysChem</i>, vol. 9, no. 7, Wiley-Blackwell,
    2008, pp. 954–66, doi:<a href="https://doi.org/10.1002/cphc.200700662">10.1002/cphc.200700662</a>.'
  short: H.L. Janovjak, T. Sapra, A. Kedrov, D. Mueller, ChemPhysChem 9 (2008) 954–966.
date_created: 2018-12-11T12:03:11Z
date_published: 2008-05-02T00:00:00Z
date_updated: 2019-04-26T07:22:27Z
day: '02'
doi: 10.1002/cphc.200700662
extern: 1
intvolume: '         9'
issue: '7'
month: '05'
page: 954 - 966
publication: ChemPhysChem
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2992'
quality_controlled: 0
status: public
title: 'From valleys to ridges: Exploring the energy landscape of single membrane
  proteins'
type: review
volume: 9
year: '2008'
...
---
_id: '3435'
abstract:
- lang: eng
  text: We develop a new method for estimating effective population sizes, Ne, and
    selection coefficients, s, from time-series data of allele frequencies sampled
    from a single diallelic locus. The method is based on calculating transition probabilities,
    using a numerical solution of the diffusion process, and assuming independent
    binomial sampling from this diffusion process at each time point. We apply the
    method in two example applications. First, we estimate selection coefficients
    acting on the CCR5-Δ32 mutation on the basis of published samples of contemporary
    and ancient human DNA. We show that the data are compatible with the assumption
    of s = 0, although moderate amounts of selection acting on this mutation cannot
    be excluded. In our second example, we estimate the selection coefficient acting
    on a mutation segregating in an experimental phage population. We show that the
    selection coefficient acting on this mutation is ~0.43.
author:
- first_name: Jonathan P
  full_name: Jonathan Bollback
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
- first_name: Thomas
  full_name: York, Thomas L
  last_name: York
- first_name: Rasmus
  full_name: Nielsen, Rasmus
  last_name: Nielsen
citation:
  ama: Bollback JP, York T, Nielsen R. Estimation of 2Nes From Temporal Allele Frequency
    Data. <i>Genetics</i>. 2008;179(1):497-502. doi:<a href="https://doi.org/10.1534/genetics.107.085019">10.1534/genetics.107.085019</a>
  apa: Bollback, J. P., York, T., &#38; Nielsen, R. (2008). Estimation of 2Nes From
    Temporal Allele Frequency Data. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1534/genetics.107.085019">https://doi.org/10.1534/genetics.107.085019</a>
  chicago: Bollback, Jonathan P, Thomas York, and Rasmus Nielsen. “Estimation of 2Nes
    From Temporal Allele Frequency Data.” <i>Genetics</i>. Genetics Society of America,
    2008. <a href="https://doi.org/10.1534/genetics.107.085019">https://doi.org/10.1534/genetics.107.085019</a>.
  ieee: J. P. Bollback, T. York, and R. Nielsen, “Estimation of 2Nes From Temporal
    Allele Frequency Data,” <i>Genetics</i>, vol. 179, no. 1. Genetics Society of
    America, pp. 497–502, 2008.
  ista: Bollback JP, York T, Nielsen R. 2008. Estimation of 2Nes From Temporal Allele
    Frequency Data. Genetics. 179(1), 497–502.
  mla: Bollback, Jonathan P., et al. “Estimation of 2Nes From Temporal Allele Frequency
    Data.” <i>Genetics</i>, vol. 179, no. 1, Genetics Society of America, 2008, pp.
    497–502, doi:<a href="https://doi.org/10.1534/genetics.107.085019">10.1534/genetics.107.085019</a>.
  short: J.P. Bollback, T. York, R. Nielsen, Genetics 179 (2008) 497–502.
date_created: 2018-12-11T12:03:19Z
date_published: 2008-05-01T00:00:00Z
date_updated: 2021-01-12T07:43:27Z
day: '01'
doi: 10.1534/genetics.107.085019
extern: 1
intvolume: '       179'
issue: '1'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390626
month: '05'
oa: 1
page: 497 - 502
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '2965'
quality_controlled: 0
status: public
title: Estimation of 2Nes From Temporal Allele Frequency Data
type: journal_article
volume: 179
year: '2008'
...
---
_id: '3501'
abstract:
- lang: eng
  text: |-
    The Wikipedia is a collaborative encyclopedia: anyone can contribute to its articles simply by clicking on an &quot;edit&quot; button. The open nature of the Wikipedia has been key to its success, but has also created a challenge: how can readers develop an informed opinion on its reliability? We propose a system that computes quantitative values of trust for the text in Wikipedia articles; these trust values provide an indication of text reliability.

    The system uses as input the revision history of each article, as well as information about the reputation of the contributing authors, as provided by a reputation system. The trust of a word in an article is computed on the basis of the reputation of the original author of the word, as well as the reputation of all authors who edited text near the word. The algorithm computes word trust values that vary smoothly across the text; the trust values can be visualized using varying text-background colors. The algorithm ensures that all changes to an article's text are reflected in the trust values, preventing surreptitious content changes.

    We have implemented the proposed system, and we have used it to compute and display the trust of the text of thousands of articles of the English Wikipedia. To validate our trust-computation algorithms, we show that text labeled as low-trust has a significantly higher probability of being edited in the future than text labeled as high-trust.
acknowledgement: 'This research has been partially supported by the CITRIS: Center
  for Information Technology Research in the Interest of Society.'
author:
- first_name: B Thomas
  full_name: Adler, B Thomas
  last_name: Adler
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Luca
  full_name: de Alfaro, Luca
  last_name: De Alfaro
- first_name: Marco
  full_name: Faella, Marco
  last_name: Faella
- first_name: Ian
  full_name: Pye, Ian
  last_name: Pye
- first_name: Vishwanath
  full_name: Raman, Vishwanath
  last_name: Raman
citation:
  ama: 'Adler BT, Chatterjee K, De Alfaro L, Faella M, Pye I, Raman V. Assigning trust
    to Wikipedia content. In: ACM; 2008. doi:<a href="https://doi.org/10.1145/1822258.1822293">10.1145/1822258.1822293</a>'
  apa: 'Adler, B. T., Chatterjee, K., De Alfaro, L., Faella, M., Pye, I., &#38; Raman,
    V. (2008). Assigning trust to Wikipedia content. Presented at the WikiSym: International
    Symposium on Wikis, ACM. <a href="https://doi.org/10.1145/1822258.1822293">https://doi.org/10.1145/1822258.1822293</a>'
  chicago: Adler, B Thomas, Krishnendu Chatterjee, Luca De Alfaro, Marco Faella, Ian
    Pye, and Vishwanath Raman. “Assigning Trust to Wikipedia Content.” ACM, 2008.
    <a href="https://doi.org/10.1145/1822258.1822293">https://doi.org/10.1145/1822258.1822293</a>.
  ieee: 'B. T. Adler, K. Chatterjee, L. De Alfaro, M. Faella, I. Pye, and V. Raman,
    “Assigning trust to Wikipedia content,” presented at the WikiSym: International
    Symposium on Wikis, 2008.'
  ista: 'Adler BT, Chatterjee K, De Alfaro L, Faella M, Pye I, Raman V. 2008. Assigning
    trust to Wikipedia content. WikiSym: International Symposium on Wikis.'
  mla: Adler, B. Thomas, et al. <i>Assigning Trust to Wikipedia Content</i>. ACM,
    2008, doi:<a href="https://doi.org/10.1145/1822258.1822293">10.1145/1822258.1822293</a>.
  short: B.T. Adler, K. Chatterjee, L. De Alfaro, M. Faella, I. Pye, V. Raman, in:,
    ACM, 2008.
conference:
  name: 'WikiSym: International Symposium on Wikis'
date_created: 2018-12-11T12:03:40Z
date_published: 2008-09-10T00:00:00Z
date_updated: 2021-01-12T07:43:53Z
day: '10'
doi: 10.1145/1822258.1822293
extern: 1
month: '09'
publication_status: published
publisher: ACM
publist_id: '2886'
quality_controlled: 0
status: public
title: Assigning trust to Wikipedia content
type: conference
year: '2008'
...
---
_id: '3502'
abstract:
- lang: eng
  text: 'In content-driven reputation systems for collaborative content, users gain
    or lose reputation according to how their contributions fare: authors of long-lived
    contributions gain reputation, while authors of reverted contributions lose reputation.
    Existing content-driven systems are prone to Sybil attacks, in which multiple
    identities, controlled by the same person, perform coordinated actions to increase
    their reputation. We show that content-driven reputation systems can be made resistant
    to such attacks by taking advantage of thefact that the reputation increments
    and decrements depend on content modifications, which are visible to all. We present
    an algorithm for content-driven reputation that prevents a set of identities from
    increasing their maximum reputation without doing any useful work. Here, work
    is considered useful if it causes content to evolve in a direction that is consistent
    with the actions of high-reputation users. We argue that the content modifications
    that require no effort, such as the insertion or deletion of arbitrary text, are
    invariably non-useful. We prove a truthfullness result for the resulting system,
    stating that users who wish to perform a contribution do not gain by employing
    complex contribution schemes, compared to simply performing the contribution at
    once. In particular, splitting the contribution in multiple portions, or employing
    the coordinated actions of multiple identities, do not yield additional reputation.
    Taken together, these results indicate that content-driven systems can be made
    robust with respect to Sybil attacks. Copyright 2008 ACM.'
acknowledgement: 'This research has been partially supported by the CITRIS: Center
  for Information Technology Research in the Interest of Society.'
author:
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Luca
  full_name: de Alfaro, Luca
  last_name: De Alfaro
- first_name: Ian
  full_name: Pye, Ian
  last_name: Pye
citation:
  ama: 'Chatterjee K, De Alfaro L, Pye I. Robust content-driven reputation. In: ACM;
    2008:33-42. doi:<a href="https://doi.org/10.1145/1456377.1456387 ">10.1145/1456377.1456387
    </a>'
  apa: 'Chatterjee, K., De Alfaro, L., &#38; Pye, I. (2008). Robust content-driven
    reputation (pp. 33–42). Presented at the AISec: Artificial Intelligence and Security,
    ACM. <a href="https://doi.org/10.1145/1456377.1456387 ">https://doi.org/10.1145/1456377.1456387
    </a>'
  chicago: Chatterjee, Krishnendu, Luca De Alfaro, and Ian Pye. “Robust Content-Driven
    Reputation,” 33–42. ACM, 2008. <a href="https://doi.org/10.1145/1456377.1456387
    ">https://doi.org/10.1145/1456377.1456387 </a>.
  ieee: 'K. Chatterjee, L. De Alfaro, and I. Pye, “Robust content-driven reputation,”
    presented at the AISec: Artificial Intelligence and Security, 2008, pp. 33–42.'
  ista: 'Chatterjee K, De Alfaro L, Pye I. 2008. Robust content-driven reputation.
    AISec: Artificial Intelligence and Security, 33–42.'
  mla: Chatterjee, Krishnendu, et al. <i>Robust Content-Driven Reputation</i>. ACM,
    2008, pp. 33–42, doi:<a href="https://doi.org/10.1145/1456377.1456387 ">10.1145/1456377.1456387
    </a>.
  short: K. Chatterjee, L. De Alfaro, I. Pye, in:, ACM, 2008, pp. 33–42.
conference:
  name: 'AISec: Artificial Intelligence and Security'
date_created: 2018-12-11T12:03:40Z
date_published: 2008-10-31T00:00:00Z
date_updated: 2021-01-12T07:43:54Z
day: '31'
doi: '10.1145/1456377.1456387 '
extern: 1
month: '10'
page: 33 - 42
publication_status: published
publisher: ACM
publist_id: '2885'
quality_controlled: 0
status: public
title: Robust content-driven reputation
type: conference
year: '2008'
...
---
_id: '3504'
abstract:
- lang: eng
  text: "Simulation and bisimulation metrics for stochastic systems provide a quantitative
    gen- eralization of the classical simulation and bisimulation relations. These
    metrics capture the similarity of states with respect to quantitative specifications
    written in the quantitative μ-calculus and related probabilistic logics.\r\nWe
    present algorithms for computing the metrics on Markov decision processes (MDPs),
    turn- based stochastic games, and concurrent games. For turn-based games and MDPs,
    we provide a polynomial-time algorithm based on linear programming for the computation
    of the one-step metric distance between states. The algorithm improves on the
    previously known exponential-time algo- rithm based on a reduction to the theory
    of reals. We then present PSPACE algorithms for both the decision problem and
    the problem of approximating the metric distance between two states, matching
    the best known bound for Markov chains. For the bisimulation kernel of the metric,
    which corresponds to probabilistic bisimulation, our algorithm works in time O(n4)
    for both turn-based games and MDPs; improving the previously best known O(n9 ·
    log(n)) time algorithm for MDPs. For a concurrent game G, we show that computing
    the exact distance between states is at least as hard as computing the value of
    concurrent reachability games and the square-root-sum problem in computational
    geometry. We show that checking whether the metric distance is bounded by a rational
    r, can be accomplished via a reduction to the theory of real closed fields, involving
    a\r\nformula with three quantifier alternations, yielding O(|G|O(|G|5)) time complexity,
    improving the previously known reduction with O(|G|O(|G|7)) time complexity. These
    algorithms can be iterated\r\nto approximate the metrics using binary search."
acknowledgement: This research was supported in part by the NSF grants CCR-0132780
  and CNS-0720884.
alternative_title:
- LIPIcs
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Luca
  full_name: De Alfaro, Luca
  last_name: De Alfaro
- first_name: Ritankar
  full_name: Majumdar, Ritankar
  last_name: Majumdar
- first_name: Vishwanath
  full_name: Raman, Vishwanath
  last_name: Raman
citation:
  ama: 'Chatterjee K, De Alfaro L, Majumdar R, Raman V. Algorithms for game metrics.
    In: Vol 2. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2008:107-118. doi:<a
    href="https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745">10.4230/LIPIcs.FSTTCS.2008.1745</a>'
  apa: 'Chatterjee, K., De Alfaro, L., Majumdar, R., &#38; Raman, V. (2008). Algorithms
    for game metrics (Vol. 2, pp. 107–118). Presented at the FSTTCS: Foundations of
    Software Technology and Theoretical Computer Science, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745">https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745</a>'
  chicago: Chatterjee, Krishnendu, Luca De Alfaro, Ritankar Majumdar, and Vishwanath
    Raman. “Algorithms for Game Metrics,” 2:107–18. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2008. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745">https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745</a>.
  ieee: 'K. Chatterjee, L. De Alfaro, R. Majumdar, and V. Raman, “Algorithms for game
    metrics,” presented at the FSTTCS: Foundations of Software Technology and Theoretical
    Computer Science, 2008, vol. 2, pp. 107–118.'
  ista: 'Chatterjee K, De Alfaro L, Majumdar R, Raman V. 2008. Algorithms for game
    metrics. FSTTCS: Foundations of Software Technology and Theoretical Computer Science,
    LIPIcs, vol. 2, 107–118.'
  mla: Chatterjee, Krishnendu, et al. <i>Algorithms for Game Metrics</i>. Vol. 2,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2008, pp. 107–18, doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2008.1745">10.4230/LIPIcs.FSTTCS.2008.1745</a>.
  short: K. Chatterjee, L. De Alfaro, R. Majumdar, V. Raman, in:, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2008, pp. 107–118.
conference:
  name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
date_created: 2018-12-11T12:03:40Z
date_published: 2008-12-05T00:00:00Z
date_updated: 2023-02-23T11:46:14Z
day: '05'
ddc:
- '000'
doi: 10.4230/LIPIcs.FSTTCS.2008.1745
extern: '1'
file:
- access_level: open_access
  checksum: 0a447454a24e273f7ddf51dbfe47f877
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-10T10:01:21Z
  date_updated: 2020-07-14T12:46:12Z
  file_id: '6398'
  file_name: 2008_LIPIcs_Chatterjee.pdf
  file_size: 442139
  relation: main_file
file_date_updated: 2020-07-14T12:46:12Z
has_accepted_license: '1'
intvolume: '         2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 107 - 118
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '2883'
quality_controlled: '1'
related_material:
  record:
  - id: '3868'
    relation: later_version
    status: public
status: public
title: Algorithms for game metrics
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2008'
...
---
_id: '3516'
abstract:
- lang: eng
  text: Temporal coding is a means of representing information by the time, as opposed
    to the rate, at which neurons fire. Evidence of temporal coding in the hippocampus
    comes from place cells, whose spike times relative to theta oscillations reflect
    a rat's position while running along stereotyped trajectories. This arises from
    the backwards shift in cell firing relative to local theta oscillations (phase
    precession). Here we demonstrate phase precession during place-field crossings
    in an open-field foraging task. This produced spike sequences in each theta cycle
    that disambiguate the rat's trajectory through two-dimensional space and can be
    used to predict movement direction. Furthermore, position and movement direction
    were maximally predicted from firing in the early and late portions of the theta
    cycle, respectively. This represents the first direct evidence of a combined representation
    of position, trajectory and heading in the hippocampus, organized on a fine temporal
    scale by theta oscillations.
author:
- first_name: John
  full_name: Huxter,John R
  last_name: Huxter
- first_name: Timothy
  full_name: Senior,Timothy J
  last_name: Senior
- first_name: Kevin
  full_name: Allen, Kevin
  last_name: Allen
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Huxter J, Senior T, Allen K, Csicsvari JL. Theta phase-specific codes for two-dimensional
    position, trajectory and heading in the hippocampus. <i>Nature Neuroscience</i>.
    2008;11(5):587-594. doi:<a href="https://doi.org/10.1038/nn.2106">10.1038/nn.2106</a>
  apa: Huxter, J., Senior, T., Allen, K., &#38; Csicsvari, J. L. (2008). Theta phase-specific
    codes for two-dimensional position, trajectory and heading in the hippocampus.
    <i>Nature Neuroscience</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nn.2106">https://doi.org/10.1038/nn.2106</a>
  chicago: Huxter, John, Timothy Senior, Kevin Allen, and Jozsef L Csicsvari. “Theta
    Phase-Specific Codes for Two-Dimensional Position, Trajectory and Heading in the
    Hippocampus.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2008. <a href="https://doi.org/10.1038/nn.2106">https://doi.org/10.1038/nn.2106</a>.
  ieee: J. Huxter, T. Senior, K. Allen, and J. L. Csicsvari, “Theta phase-specific
    codes for two-dimensional position, trajectory and heading in the hippocampus,”
    <i>Nature Neuroscience</i>, vol. 11, no. 5. Nature Publishing Group, pp. 587–594,
    2008.
  ista: Huxter J, Senior T, Allen K, Csicsvari JL. 2008. Theta phase-specific codes
    for two-dimensional position, trajectory and heading in the hippocampus. Nature
    Neuroscience. 11(5), 587–594.
  mla: Huxter, John, et al. “Theta Phase-Specific Codes for Two-Dimensional Position,
    Trajectory and Heading in the Hippocampus.” <i>Nature Neuroscience</i>, vol. 11,
    no. 5, Nature Publishing Group, 2008, pp. 587–94, doi:<a href="https://doi.org/10.1038/nn.2106">10.1038/nn.2106</a>.
  short: J. Huxter, T. Senior, K. Allen, J.L. Csicsvari, Nature Neuroscience 11 (2008)
    587–594.
date_created: 2018-12-11T12:03:44Z
date_published: 2008-05-29T00:00:00Z
date_updated: 2021-01-12T07:44:00Z
day: '29'
doi: 10.1038/nn.2106
extern: 1
intvolume: '        11'
issue: '5'
month: '05'
page: 587 - 594
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2869'
quality_controlled: 0
status: public
title: Theta phase-specific codes for two-dimensional position, trajectory and heading
  in the hippocampus
type: journal_article
volume: 11
year: '2008'
...
---
_id: '3520'
abstract:
- lang: eng
  text: The hippocampus is thought to be involved in episodic memory formation by
    reactivating traces of waking experience during sleep. Indeed, the joint firing
    of spatially tuned pyramidal cells encoding nearby places recur during sleep.
    We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places
    increased relative to the sleep session before exploration. This cofiring increase
    depended on the number of times that cells fired together with short latencies
    ( &lt; 50 ms) during exploration, and was strongest between cells representing
    the most visited places. This is indicative of a Hebbian learning rule in which
    changes in firing associations between cells are determined by the number of waking
    coincident firing events. In contrast, cells encoding different locations reduced
    their cofiring in proportion to the number of times that they fired independently.
    Together these data indicate that reactivated patterns are shaped by both positive
    and negative changes in cofiring, which are determined by recent behavior.
author:
- first_name: Joseph
  full_name: Joseph O'Neill
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Timothy
  full_name: Senior,Timothy J
  last_name: Senior
- first_name: Kevin
  full_name: Allen, Kevin
  last_name: Allen
- first_name: John
  full_name: Huxter,John R
  last_name: Huxter
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. Reactivation of experience-dependent
    cell assembly patterns in the hippocampus. <i>Nature Neuroscience</i>. 2008;11(2):209-215.
    doi:<a href="https://doi.org/10.1038/nn2037">10.1038/nn2037</a>
  apa: O’Neill, J., Senior, T., Allen, K., Huxter, J., &#38; Csicsvari, J. L. (2008).
    Reactivation of experience-dependent cell assembly patterns in the hippocampus.
    <i>Nature Neuroscience</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nn2037">https://doi.org/10.1038/nn2037</a>
  chicago: O’Neill, Joseph, Timothy Senior, Kevin Allen, John Huxter, and Jozsef L
    Csicsvari. “Reactivation of Experience-Dependent Cell Assembly Patterns in the
    Hippocampus.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2008. <a href="https://doi.org/10.1038/nn2037">https://doi.org/10.1038/nn2037</a>.
  ieee: J. O’Neill, T. Senior, K. Allen, J. Huxter, and J. L. Csicsvari, “Reactivation
    of experience-dependent cell assembly patterns in the hippocampus,” <i>Nature
    Neuroscience</i>, vol. 11, no. 2. Nature Publishing Group, pp. 209–215, 2008.
  ista: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. 2008. Reactivation of
    experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience.
    11(2), 209–215.
  mla: O’Neill, Joseph, et al. “Reactivation of Experience-Dependent Cell Assembly
    Patterns in the Hippocampus.” <i>Nature Neuroscience</i>, vol. 11, no. 2, Nature
    Publishing Group, 2008, pp. 209–15, doi:<a href="https://doi.org/10.1038/nn2037">10.1038/nn2037</a>.
  short: J. O’Neill, T. Senior, K. Allen, J. Huxter, J.L. Csicsvari, Nature Neuroscience
    11 (2008) 209–215.
date_created: 2018-12-11T12:03:46Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:02Z
day: '01'
doi: 10.1038/nn2037
extern: 1
intvolume: '        11'
issue: '2'
month: '02'
page: 209 - 215
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2864'
quality_controlled: 0
status: public
title: Reactivation of experience-dependent cell assembly patterns in the hippocampus
type: journal_article
volume: 11
year: '2008'
...
---
_id: '3530'
abstract:
- lang: eng
  text: In the cerebral cortex, GABAergic interneurons are often regarded as fast-spiking
    cells. We have identified a type of slow-spiking interneuron that offers distinct
    contributions to network activity. “Ivy” cells, named after their dense and fine
    axons innervating mostly basal and oblique pyramidal cell dendrites, are more
    numerous than the parvalbumin-expressing basket, bistratified, or axo-axonic cells.
    Ivy cells express nitric oxide synthase, neuropeptide Y, and high levels of GABA(A)
    receptor alpha 1 subunit; they discharge at a low frequency with wide spikes in
    vivo, yet are distinctively phase-locked to behaviorally relevant network rhythms
    including theta, gamma, and ripple oscillations. Paired recordings in vitro showed
    that Ivy cells receive depressing EPSPs from pyramidal cells, which in turn receive
    slowly rising and decaying inhibitory input from Ivy cells. In contrast to fast-spiking
    interneurons operating with millisecond precision, the highly abundant Ivy cells
    express presynaptically acting neuromodulators and regulate the excitability of
    pyramidal cell dendrites through slowly rising and decaying GABAergic inputs.
author:
- first_name: Pablo
  full_name: Fuentealba,Pablo
  last_name: Fuentealba
- first_name: Rahima
  full_name: Begum,Rahima
  last_name: Begum
- first_name: Marco
  full_name: Capogna,Marco
  last_name: Capogna
- first_name: Shozo
  full_name: Jinno,Shozo
  last_name: Jinno
- first_name: Laszlo
  full_name: Marton,Laszlo F
  last_name: Marton
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Alex
  full_name: Thomson,Alex
  last_name: Thomson
- first_name: Péter
  full_name: Somogyi, Péter
  last_name: Somogyi
- first_name: Thomas
  full_name: Klausberger,Thomas
  last_name: Klausberger
citation:
  ama: 'Fuentealba P, Begum R, Capogna M, et al. Ivy cells: A population of nitric-oxide-producing,
    slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
    <i>Neuron</i>. 2008;57(6):917-929. doi:<a href="https://doi.org/10.1016/j.neuron.2008.01.034">10.1016/j.neuron.2008.01.034</a>'
  apa: 'Fuentealba, P., Begum, R., Capogna, M., Jinno, S., Marton, L., Csicsvari,
    J. L., … Klausberger, T. (2008). Ivy cells: A population of nitric-oxide-producing,
    slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2008.01.034">https://doi.org/10.1016/j.neuron.2008.01.034</a>'
  chicago: 'Fuentealba, Pablo, Rahima Begum, Marco Capogna, Shozo Jinno, Laszlo Marton,
    Jozsef L Csicsvari, Alex Thomson, Péter Somogyi, and Thomas Klausberger. “Ivy
    Cells: A Population of Nitric-Oxide-Producing, Slow-Spiking GABAergic Neurons
    and Their Involvement in Hippocampal Network Activity.” <i>Neuron</i>. Elsevier,
    2008. <a href="https://doi.org/10.1016/j.neuron.2008.01.034">https://doi.org/10.1016/j.neuron.2008.01.034</a>.'
  ieee: 'P. Fuentealba <i>et al.</i>, “Ivy cells: A population of nitric-oxide-producing,
    slow-spiking GABAergic neurons and their involvement in hippocampal network activity,”
    <i>Neuron</i>, vol. 57, no. 6. Elsevier, pp. 917–929, 2008.'
  ista: 'Fuentealba P, Begum R, Capogna M, Jinno S, Marton L, Csicsvari JL, Thomson
    A, Somogyi P, Klausberger T. 2008. Ivy cells: A population of nitric-oxide-producing,
    slow-spiking GABAergic neurons and their involvement in hippocampal network activity.
    Neuron. 57(6), 917–929.'
  mla: 'Fuentealba, Pablo, et al. “Ivy Cells: A Population of Nitric-Oxide-Producing,
    Slow-Spiking GABAergic Neurons and Their Involvement in Hippocampal Network Activity.”
    <i>Neuron</i>, vol. 57, no. 6, Elsevier, 2008, pp. 917–29, doi:<a href="https://doi.org/10.1016/j.neuron.2008.01.034">10.1016/j.neuron.2008.01.034</a>.'
  short: P. Fuentealba, R. Begum, M. Capogna, S. Jinno, L. Marton, J.L. Csicsvari,
    A. Thomson, P. Somogyi, T. Klausberger, Neuron 57 (2008) 917–929.
date_created: 2018-12-11T12:03:49Z
date_published: 2008-03-27T00:00:00Z
date_updated: 2021-01-12T07:44:06Z
day: '27'
doi: 10.1016/j.neuron.2008.01.034
extern: 1
intvolume: '        57'
issue: '6'
month: '03'
page: 917 - 929
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2855'
quality_controlled: 0
status: public
title: 'Ivy cells: A population of nitric-oxide-producing, slow-spiking GABAergic
  neurons and their involvement in hippocampal network activity'
type: journal_article
volume: 57
year: '2008'
...
---
_id: '3534'
author:
- first_name: David
  full_name: Dupret, David
  last_name: Dupret
- first_name: Barty
  full_name: Pleydell-Bouverie, Barty
  last_name: Pleydell Bouverie
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Dupret D, Pleydell Bouverie B, Csicsvari JL. Inhibitory interneurons and network
    oscillations. <i>PNAS</i>. 2008;105(47):18079-18080. doi:<a href="https://doi.org/10.1073/pnas.0810064105">10.1073/pnas.0810064105</a>
  apa: Dupret, D., Pleydell Bouverie, B., &#38; Csicsvari, J. L. (2008). Inhibitory
    interneurons and network oscillations. <i>PNAS</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.0810064105">https://doi.org/10.1073/pnas.0810064105</a>
  chicago: Dupret, David, Barty Pleydell Bouverie, and Jozsef L Csicsvari. “Inhibitory
    Interneurons and Network Oscillations.” <i>PNAS</i>. National Academy of Sciences,
    2008. <a href="https://doi.org/10.1073/pnas.0810064105">https://doi.org/10.1073/pnas.0810064105</a>.
  ieee: D. Dupret, B. Pleydell Bouverie, and J. L. Csicsvari, “Inhibitory interneurons
    and network oscillations,” <i>PNAS</i>, vol. 105, no. 47. National Academy of
    Sciences, pp. 18079–18080, 2008.
  ista: Dupret D, Pleydell Bouverie B, Csicsvari JL. 2008. Inhibitory interneurons
    and network oscillations. PNAS. 105(47), 18079–18080.
  mla: Dupret, David, et al. “Inhibitory Interneurons and Network Oscillations.” <i>PNAS</i>,
    vol. 105, no. 47, National Academy of Sciences, 2008, pp. 18079–80, doi:<a href="https://doi.org/10.1073/pnas.0810064105">10.1073/pnas.0810064105</a>.
  short: D. Dupret, B. Pleydell Bouverie, J.L. Csicsvari, PNAS 105 (2008) 18079–18080.
date_created: 2018-12-11T12:03:50Z
date_published: 2008-11-25T00:00:00Z
date_updated: 2021-01-12T07:44:08Z
day: '25'
doi: 10.1073/pnas.0810064105
extern: 1
intvolume: '       105'
issue: '47'
month: '11'
page: 18079 - 18080
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2852'
quality_controlled: 0
status: public
title: Inhibitory interneurons and network oscillations
type: journal_article
volume: 105
year: '2008'
...
---
_id: '3537'
abstract:
- lang: eng
  text: 'Hippocampal place cells that fire together within the same cycle of theta
    oscillations represent the sequence of positions (movement trajectory) that a
    rat traverses on a linear track. Furthermore, it has been suggested that the encoding
    of these and other types of temporal memory sequences is organized by gamma oscillations
    nested within theta oscillations. Here, we examined whether gamma-related firing
    of place cells permits such discrete temporal coding. We found that gamma-modulated
    CA1 pyramidal cells separated into two classes on the basis of gamma firing phases
    during waking theta periods. These groups also differed in terms of their spike
    waveforms, firing rates, and burst firing tendency. During gamma oscillations
    one group''s firing became restricted to theta phases associated with the highest
    gamma power. Consequently, on the linear track, cells in this group often failed
    to fire early in theta-phase precession (as the rat entered the place field) if
    gamma oscillations were present. The second group fired throughout the theta cycle
    during gamma oscillations, and maintained gamma-modulated firing at different
    stages of theta-phase precession. Our results suggest that the two different pyramidal
    cell classes may support different types of population codes within a theta cycle:
    one in which spike sequences representing movement trajectories occur across subsequent
    gamma cycles nested within each theta cycle, and another in which firing in synchronized
    gamma discharges without temporal sequences encode a representation of location.
    We propose that gamma oscillations during theta-phase precession organize the
    mnemonic recall of population patterns representing places and movement paths.'
author:
- first_name: Timothy
  full_name: Senior,Timothy J
  last_name: Senior
- first_name: John
  full_name: Huxter,John R
  last_name: Huxter
- first_name: Kevin
  full_name: Allen, Kevin
  last_name: Allen
- first_name: Joseph
  full_name: Joseph O'Neill
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. Gamma oscillatory firing
    reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus.
    <i>Journal of Neuroscience</i>. 2008;28(9):2274-2286. doi:<a href="https://doi.org/10.1523/JNEUROSCI.4669-07.2008">10.1523/JNEUROSCI.4669-07.2008</a>
  apa: Senior, T., Huxter, J., Allen, K., O’Neill, J., &#38; Csicsvari, J. L. (2008).
    Gamma oscillatory firing reveals distinct populations of pyramidal cells in the
    CA1 region of the hippocampus. <i>Journal of Neuroscience</i>. Society for Neuroscience.
    <a href="https://doi.org/10.1523/JNEUROSCI.4669-07.2008">https://doi.org/10.1523/JNEUROSCI.4669-07.2008</a>
  chicago: Senior, Timothy, John Huxter, Kevin Allen, Joseph O’Neill, and Jozsef L
    Csicsvari. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal
    Cells in the CA1 Region of the Hippocampus.” <i>Journal of Neuroscience</i>. Society
    for Neuroscience, 2008. <a href="https://doi.org/10.1523/JNEUROSCI.4669-07.2008">https://doi.org/10.1523/JNEUROSCI.4669-07.2008</a>.
  ieee: T. Senior, J. Huxter, K. Allen, J. O’Neill, and J. L. Csicsvari, “Gamma oscillatory
    firing reveals distinct populations of pyramidal cells in the CA1 region of the
    hippocampus,” <i>Journal of Neuroscience</i>, vol. 28, no. 9. Society for Neuroscience,
    pp. 2274–2286, 2008.
  ista: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. 2008. Gamma oscillatory
    firing reveals distinct populations of pyramidal cells in the CA1 region of the
    hippocampus. Journal of Neuroscience. 28(9), 2274–2286.
  mla: Senior, Timothy, et al. “Gamma Oscillatory Firing Reveals Distinct Populations
    of Pyramidal Cells in the CA1 Region of the Hippocampus.” <i>Journal of Neuroscience</i>,
    vol. 28, no. 9, Society for Neuroscience, 2008, pp. 2274–86, doi:<a href="https://doi.org/10.1523/JNEUROSCI.4669-07.2008">10.1523/JNEUROSCI.4669-07.2008</a>.
  short: T. Senior, J. Huxter, K. Allen, J. O’Neill, J.L. Csicsvari, Journal of Neuroscience
    28 (2008) 2274–2286.
date_created: 2018-12-11T12:03:51Z
date_published: 2008-02-27T00:00:00Z
date_updated: 2021-01-12T07:44:09Z
day: '27'
doi: 10.1523/JNEUROSCI.4669-07.2008
extern: 1
intvolume: '        28'
issue: '9'
month: '02'
page: 2274 - 2286
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2847'
quality_controlled: 0
status: public
title: Gamma oscillatory firing reveals distinct populations of pyramidal cells in
  the CA1 region of the hippocampus
type: journal_article
volume: 28
year: '2008'
...
---
_id: '3544'
abstract:
- lang: eng
  text: In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced
    synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies
    movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly
    and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate
    rhythms might also emerge acutely from disrupted dopamine transmission. The neural
    basis of these abnormal beta oscillations is unclear, and how they might compromise
    information processing, or how they arise, is unknown. Using a 6-hydroxydopamine-lesioned
    rodent model of PD, we demonstrate that beta oscillations are inappropriately
    exaggerated, compared with controls, in a brain-state-dependent manner after chronic
    dopamine loss. Exaggerated beta oscillations are expressed at the levels of single
    neurons and small neuronal ensembles, and are focally present and spatially distributed
    within STN. They are also expressed in synchronous population activities, as evinced
    by oscillatory local field potentials, in STN and cortex. Excessively synchronized
    beta oscillations reduce the information coding capacity of STN neuronal ensembles,
    which may contribute to parkinsonian motor impairment. Acute disruption of dopamine
    transmission in control animals with antagonists of D-1/D-2 receptors did not
    exaggerate STN or cortical beta oscillations. Moreover, beta oscillations were
    not exaggerated until several days after 6-hydroxydopamine injections. Thus, contrary
    to predictions, abnormally amplified beta oscillations in cortico-STN circuits
    do not result simply from an acute absence of dopamine receptor stimulation, but
    are instead delayed sequelae of chronic dopamine depletion. Targeting the plastic
    processes underlying the delayed emergence of pathological beta oscillations after
    continuing dopaminergic dysfunction may offer considerable therapeutic promise.
author:
- first_name: Nicolas
  full_name: Mallet,Nicolas
  last_name: Mallet
- first_name: Alek
  full_name: Pogosyan,Alek
  last_name: Pogosyan
- first_name: Andrew
  full_name: Sharott,Andrew
  last_name: Sharott
- first_name: Jozsef L
  full_name: Jozsef Csicsvari
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: John
  full_name: Bolam, John Paul
  last_name: Bolam
- first_name: Peter
  full_name: Brown,Peter
  last_name: Brown
- first_name: Peter
  full_name: Magill,Peter J
  last_name: Magill
citation:
  ama: Mallet N, Pogosyan A, Sharott A, et al. Disrupted dopamine transmission and
    the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral
    cortex. <i>Journal of Neuroscience</i>. 2008;28(18):4795-4806. doi:<a href="https://doi.org/10.1523/JNEUROSCI.0123-08.2008">10.1523/JNEUROSCI.0123-08.2008</a>
  apa: Mallet, N., Pogosyan, A., Sharott, A., Csicsvari, J. L., Bolam, J., Brown,
    P., &#38; Magill, P. (2008). Disrupted dopamine transmission and the emergence
    of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. <i>Journal
    of Neuroscience</i>. Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.0123-08.2008">https://doi.org/10.1523/JNEUROSCI.0123-08.2008</a>
  chicago: Mallet, Nicolas, Alek Pogosyan, Andrew Sharott, Jozsef L Csicsvari, John
    Bolam, Peter Brown, and Peter Magill. “Disrupted Dopamine Transmission and the
    Emergence of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral
    Cortex.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2008. <a href="https://doi.org/10.1523/JNEUROSCI.0123-08.2008">https://doi.org/10.1523/JNEUROSCI.0123-08.2008</a>.
  ieee: N. Mallet <i>et al.</i>, “Disrupted dopamine transmission and the emergence
    of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex,”
    <i>Journal of Neuroscience</i>, vol. 28, no. 18. Society for Neuroscience, pp.
    4795–4806, 2008.
  ista: Mallet N, Pogosyan A, Sharott A, Csicsvari JL, Bolam J, Brown P, Magill P.
    2008. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
    in subthalamic nucleus and cerebral cortex. Journal of Neuroscience. 28(18), 4795–4806.
  mla: Mallet, Nicolas, et al. “Disrupted Dopamine Transmission and the Emergence
    of Exaggerated Beta Oscillations in Subthalamic Nucleus and Cerebral Cortex.”
    <i>Journal of Neuroscience</i>, vol. 28, no. 18, Society for Neuroscience, 2008,
    pp. 4795–806, doi:<a href="https://doi.org/10.1523/JNEUROSCI.0123-08.2008">10.1523/JNEUROSCI.0123-08.2008</a>.
  short: N. Mallet, A. Pogosyan, A. Sharott, J.L. Csicsvari, J. Bolam, P. Brown, P.
    Magill, Journal of Neuroscience 28 (2008) 4795–4806.
date_created: 2018-12-11T12:03:53Z
date_published: 2008-04-30T00:00:00Z
date_updated: 2021-01-12T07:44:12Z
day: '30'
doi: 10.1523/JNEUROSCI.0123-08.2008
extern: 1
intvolume: '        28'
issue: '18'
month: '04'
page: 4795 - 4806
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2842'
quality_controlled: 0
status: public
title: Disrupted dopamine transmission and the emergence of exaggerated beta oscillations
  in subthalamic nucleus and cerebral cortex
type: journal_article
volume: 28
year: '2008'
...
---
_id: '3577'
alternative_title:
- Mathematics and Visualization
author:
- first_name: Silvia
  full_name: Biasotti, Silvia
  last_name: Biasotti
- first_name: Dominique
  full_name: Attali, Dominique
  last_name: Attali
- first_name: Jean
  full_name: Boissonnat, Jean-Daniel
  last_name: Boissonnat
- first_name: Herbert
  full_name: Herbert Edelsbrunner
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Gershon
  full_name: Elber, Gershon
  last_name: Elber
- first_name: Michela
  full_name: Mortara, Michela
  last_name: Mortara
- first_name: Gabriella
  full_name: Sanniti di Baja, Gabriella
  last_name: Sanniti Di Baja
- first_name: Michela
  full_name: Spagnuolo, Michela
  last_name: Spagnuolo
- first_name: Mirela
  full_name: Tanase, Mirela
  last_name: Tanase
- first_name: Remco
  full_name: Veltkam, Remco
  last_name: Veltkam
citation:
  ama: 'Biasotti S, Attali D, Boissonnat J, et al. Skeletal structures. In: <i>Shape
    Analysis and Structuring</i>. Springer; 2008:145-183. doi:<a href="https://doi.org/10.1007/978-3-540-33265-7_5">10.1007/978-3-540-33265-7_5</a>'
  apa: Biasotti, S., Attali, D., Boissonnat, J., Edelsbrunner, H., Elber, G., Mortara,
    M., … Veltkam, R. (2008). Skeletal structures. In <i>Shape Analysis and Structuring</i>
    (pp. 145–183). Springer. <a href="https://doi.org/10.1007/978-3-540-33265-7_5">https://doi.org/10.1007/978-3-540-33265-7_5</a>
  chicago: Biasotti, Silvia, Dominique Attali, Jean Boissonnat, Herbert Edelsbrunner,
    Gershon Elber, Michela Mortara, Gabriella Sanniti Di Baja, Michela Spagnuolo,
    Mirela Tanase, and Remco Veltkam. “Skeletal Structures.” In <i>Shape Analysis
    and Structuring</i>, 145–83. Springer, 2008. <a href="https://doi.org/10.1007/978-3-540-33265-7_5">https://doi.org/10.1007/978-3-540-33265-7_5</a>.
  ieee: S. Biasotti <i>et al.</i>, “Skeletal structures,” in <i>Shape Analysis and
    Structuring</i>, Springer, 2008, pp. 145–183.
  ista: 'Biasotti S, Attali D, Boissonnat J, Edelsbrunner H, Elber G, Mortara M, Sanniti
    Di Baja G, Spagnuolo M, Tanase M, Veltkam R. 2008.Skeletal structures. In: Shape
    Analysis and Structuring. Mathematics and Visualization, , 145–183.'
  mla: Biasotti, Silvia, et al. “Skeletal Structures.” <i>Shape Analysis and Structuring</i>,
    Springer, 2008, pp. 145–83, doi:<a href="https://doi.org/10.1007/978-3-540-33265-7_5">10.1007/978-3-540-33265-7_5</a>.
  short: S. Biasotti, D. Attali, J. Boissonnat, H. Edelsbrunner, G. Elber, M. Mortara,
    G. Sanniti Di Baja, M. Spagnuolo, M. Tanase, R. Veltkam, in:, Shape Analysis and
    Structuring, Springer, 2008, pp. 145–183.
date_created: 2018-12-11T12:04:03Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T07:44:25Z
day: '01'
doi: 10.1007/978-3-540-33265-7_5
extern: 1
month: '01'
page: 145 - 183
publication: Shape Analysis and Structuring
publication_status: published
publisher: Springer
publist_id: '2808'
quality_controlled: 0
status: public
title: Skeletal structures
type: book_chapter
year: '2008'
...
---
_id: '3591'
abstract:
- lang: eng
  text: The controlled internalization of membrane receptors and lipids is crucial
    for cells to control signaling pathways and interact with their environment. During
    clathrin-mediated endocytosis, membrane constituents are transported via endocytic
    vesicles into early endosomes, from which they are further distributed within
    the cell. The small guanosine triphosphatase (GTPase) Rab5 is both required and
    sufficient for the formation of these early endosomes and can be used to experimentally
    address endocytic processes. Recent evidence shows that endocytic turnover of
    E-cadherin regulates the migration of mesendodermal cells during zebrafish gastrulation
    by modulating their adhesive interactions with neighboring cells. This in turn
    leads to effective and synchronized movement within the embryo. In this review,
    we discuss techniques to manipulate E-cadherin endocytosis by morpholino-mediated
    knockdown of rab5 during zebrafish gastrulation. We describe the use of antibodies
    specifically directed against zebrafish E-cadherin to detect its intracellular
    localization and of in situ hybridization and primary cell culture to reveal patterns
    of cell migration and adhesion, respectively
article_processing_charge: No
author:
- first_name: Florian
  full_name: Ulrich, Florian
  last_name: Ulrich
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Ulrich F, Heisenberg C-PJ. Probing E-cadherin endocytosis by morpholino-mediated
    Rab5 knock-down in zebrafish. <i>Methods in Molecular Biology</i>. 2008;440:371-387.
    doi:<a href="https://doi.org/10.1007/978-1-59745-178-9_27">10.1007/978-1-59745-178-9_27</a>
  apa: Ulrich, F., &#38; Heisenberg, C.-P. J. (2008). Probing E-cadherin endocytosis
    by morpholino-mediated Rab5 knock-down in zebrafish. <i>Methods in Molecular Biology</i>.
    Springer. <a href="https://doi.org/10.1007/978-1-59745-178-9_27">https://doi.org/10.1007/978-1-59745-178-9_27</a>
  chicago: Ulrich, Florian, and Carl-Philipp J Heisenberg. “Probing E-Cadherin Endocytosis
    by Morpholino-Mediated Rab5 Knock-down in Zebrafish.” <i>Methods in Molecular
    Biology</i>. Springer, 2008. <a href="https://doi.org/10.1007/978-1-59745-178-9_27">https://doi.org/10.1007/978-1-59745-178-9_27</a>.
  ieee: F. Ulrich and C.-P. J. Heisenberg, “Probing E-cadherin endocytosis by morpholino-mediated
    Rab5 knock-down in zebrafish.,” <i>Methods in Molecular Biology</i>, vol. 440.
    Springer, pp. 371–387, 2008.
  ista: Ulrich F, Heisenberg C-PJ. 2008. Probing E-cadherin endocytosis by morpholino-mediated
    Rab5 knock-down in zebrafish. Methods in Molecular Biology. 440, 371–387.
  mla: Ulrich, Florian, and Carl-Philipp J. Heisenberg. “Probing E-Cadherin Endocytosis
    by Morpholino-Mediated Rab5 Knock-down in Zebrafish.” <i>Methods in Molecular
    Biology</i>, vol. 440, Springer, 2008, pp. 371–87, doi:<a href="https://doi.org/10.1007/978-1-59745-178-9_27">10.1007/978-1-59745-178-9_27</a>.
  short: F. Ulrich, C.-P.J. Heisenberg, Methods in Molecular Biology 440 (2008) 371–387.
date_created: 2018-12-11T12:04:08Z
date_published: 2008-01-01T00:00:00Z
date_updated: 2021-01-12T07:44:31Z
day: '01'
doi: 10.1007/978-1-59745-178-9_27
extern: '1'
intvolume: '       440'
language:
- iso: eng
month: '01'
oa_version: None
page: 371 - 387
publication: Methods in Molecular Biology
publication_status: published
publisher: Springer
publist_id: '2792'
status: public
title: Probing E-cadherin endocytosis by morpholino-mediated Rab5 knock-down in zebrafish.
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 440
year: '2008'
...
---
_id: '3599'
abstract:
- lang: eng
  text: In this paper, adaptive formation control and bio-inspired optimization are
    jointly addressed for a cluster-based satellite wireless sensor network in which
    there are multiple satellites flying in formation (MSFF) in the presence of unknown
    disturbances. The full nonlinear dynamics model describing the relative positioning
    of the MSFF system is used to develop an adaptive formation controller. First,
    the original nonlinear system is transformed into a linear controllable system
    with aperturbation term by invoking the input-output feedback linearization technique.
    Second, by using the integral feedback design scheme, the adaptive formation controller
    is presented for improving the steady-state performance of the MSFF system in
    the presence of unknown disturbances. Third, as a currently popular bio-inspired
    algorithm, PSO (particle swarm optimizer) is employed to minimize the total energy
    consumption under the required quality of service by jointly optimizing the transmission
    power and rate for each satellite. Simulation results are provided to demonstrate
    the effectiveness of the adaptive formation controller and the PSO-based optimization
    for saving the total communication energy.
author:
- first_name: Erfu
  full_name: Yang, Erfu
  last_name: Yang
- first_name: Ahmet
  full_name: Erdogan, Ahmet T
  last_name: Erdogan
- first_name: Tughrul
  full_name: Arslan, Tughrul
  last_name: Arslan
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Yang E, Erdogan A, Arslan T, Barton NH. Adaptive formation control and bio-inspired
    optimization of a cluster-based satellite wireless sensor network . In: IEEE;
    2008:432-439. doi:<a href="https://doi.org/10.1109/AHS.2008.60">10.1109/AHS.2008.60</a>'
  apa: 'Yang, E., Erdogan, A., Arslan, T., &#38; Barton, N. H. (2008). Adaptive formation
    control and bio-inspired optimization of a cluster-based satellite wireless sensor
    network  (pp. 432–439). Presented at the AHS: NASA/ESA Conference on Adaptive
    Hardware and Systems, IEEE. <a href="https://doi.org/10.1109/AHS.2008.60">https://doi.org/10.1109/AHS.2008.60</a>'
  chicago: Yang, Erfu, Ahmet Erdogan, Tughrul Arslan, and Nicholas H Barton. “Adaptive
    Formation Control and Bio-Inspired Optimization of a Cluster-Based Satellite Wireless
    Sensor Network ,” 432–39. IEEE, 2008. <a href="https://doi.org/10.1109/AHS.2008.60">https://doi.org/10.1109/AHS.2008.60</a>.
  ieee: 'E. Yang, A. Erdogan, T. Arslan, and N. H. Barton, “Adaptive formation control
    and bio-inspired optimization of a cluster-based satellite wireless sensor network
    ,” presented at the AHS: NASA/ESA Conference on Adaptive Hardware and Systems,
    2008, pp. 432–439.'
  ista: 'Yang E, Erdogan A, Arslan T, Barton NH. 2008. Adaptive formation control
    and bio-inspired optimization of a cluster-based satellite wireless sensor network
    . AHS: NASA/ESA Conference on Adaptive Hardware and Systems, 432–439.'
  mla: Yang, Erfu, et al. <i>Adaptive Formation Control and Bio-Inspired Optimization
    of a Cluster-Based Satellite Wireless Sensor Network </i>. IEEE, 2008, pp. 432–39,
    doi:<a href="https://doi.org/10.1109/AHS.2008.60">10.1109/AHS.2008.60</a>.
  short: E. Yang, A. Erdogan, T. Arslan, N.H. Barton, in:, IEEE, 2008, pp. 432–439.
conference:
  name: 'AHS: NASA/ESA Conference on Adaptive Hardware and Systems'
date_created: 2018-12-11T12:04:10Z
date_published: 2008-08-01T00:00:00Z
date_updated: 2021-01-12T07:44:34Z
day: '01'
doi: 10.1109/AHS.2008.60
extern: 1
month: '08'
page: 432 - 439
publication_status: published
publisher: IEEE
publist_id: '2784'
quality_controlled: 0
status: public
title: 'Adaptive formation control and bio-inspired optimization of a cluster-based
  satellite wireless sensor network '
type: conference
year: '2008'
...
---
_id: '3600'
abstract:
- lang: eng
  text: Scalability is one of the most important issues for optimization algorithms
    used in wireless sensor networks (WSNs) since there are often many parameters
    to be optimized at the same time. In this case it is very hard to ensure that
    an optimization algorithm can be smoothly scaled up from a low-dimensional optimization
    problem to the one with a high dimensionality. This paper addresses the scalability
    issue of a novel optimization algorithm inspired by the Shifting Balance Theory
    (SBT) of evolution in population genetics. Toward this end, a cluster-based WSN
    is employed in this paper as a benchmark to perform a comparative study. The total
    energy consumption is minimized under the required quality of service by jointly
    optimizing the transmission power and rate for each sensor node. The results obtained
    by the SBT-based algorithm are compared with the Metropolis algorithm (MA) and
    currently popular particle swarm optimizer (PSO) to assess the scaling performance
    of the three algorithms against the same WSN optimization problem.
alternative_title:
- LNCS
author:
- first_name: Erfu
  full_name: Yang, Erfu
  last_name: Yang
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Tughrul
  full_name: Arslan, Tughrul
  last_name: Arslan
- first_name: Ahmet
  full_name: Erdogan, Ahmet T
  last_name: Erdogan
citation:
  ama: 'Yang E, Barton NH, Arslan T, Erdogan A.  Scalability of a novel shifting balance
    theory-based optimization algorithm: A comparative study on a cluster-based wireless
    sensor network. In: Vol 5216. Springer; 2008:249-260. doi:<a href="https://doi.org/10.1007/978-3-540-85857-7_22">10.1007/978-3-540-85857-7_22</a>'
  apa: 'Yang, E., Barton, N. H., Arslan, T., &#38; Erdogan, A. (2008).  Scalability
    of a novel shifting balance theory-based optimization algorithm: A comparative
    study on a cluster-based wireless sensor network (Vol. 5216, pp. 249–260). Presented
    at the IECS: International Conference on Evolvable Systems, Springer. <a href="https://doi.org/10.1007/978-3-540-85857-7_22">https://doi.org/10.1007/978-3-540-85857-7_22</a>'
  chicago: 'Yang, Erfu, Nicholas H Barton, Tughrul Arslan, and Ahmet Erdogan. “ Scalability
    of a Novel Shifting Balance Theory-Based Optimization Algorithm: A Comparative
    Study on a Cluster-Based Wireless Sensor Network,” 5216:249–60. Springer, 2008.
    <a href="https://doi.org/10.1007/978-3-540-85857-7_22">https://doi.org/10.1007/978-3-540-85857-7_22</a>.'
  ieee: 'E. Yang, N. H. Barton, T. Arslan, and A. Erdogan, “ Scalability of a novel
    shifting balance theory-based optimization algorithm: A comparative study on a
    cluster-based wireless sensor network,” presented at the IECS: International Conference
    on Evolvable Systems, 2008, vol. 5216, pp. 249–260.'
  ista: 'Yang E, Barton NH, Arslan T, Erdogan A. 2008.  Scalability of a novel shifting
    balance theory-based optimization algorithm: A comparative study on a cluster-based
    wireless sensor network. IECS: International Conference on Evolvable Systems,
    LNCS, vol. 5216, 249–260.'
  mla: 'Yang, Erfu, et al. <i> Scalability of a Novel Shifting Balance Theory-Based
    Optimization Algorithm: A Comparative Study on a Cluster-Based Wireless Sensor
    Network</i>. Vol. 5216, Springer, 2008, pp. 249–60, doi:<a href="https://doi.org/10.1007/978-3-540-85857-7_22">10.1007/978-3-540-85857-7_22</a>.'
  short: E. Yang, N.H. Barton, T. Arslan, A. Erdogan, in:, Springer, 2008, pp. 249–260.
conference:
  name: 'IECS: International Conference on Evolvable Systems'
date_created: 2018-12-11T12:04:10Z
date_published: 2008-09-08T00:00:00Z
date_updated: 2021-01-12T07:44:35Z
day: '08'
doi: 10.1007/978-3-540-85857-7_22
extern: 1
intvolume: '      5216'
month: '09'
page: 249 - 260
publication_status: published
publisher: Springer
publist_id: '2783'
quality_controlled: 0
status: public
title: ' Scalability of a novel shifting balance theory-based optimization algorithm:
  A comparative study on a cluster-based wireless sensor network'
type: conference
volume: 5216
year: '2008'
...
---
_id: '3605'
abstract:
- lang: eng
  text: Many animals and plants show a correlation between the traits of the individuals
    in the mating pair, implying assortative mating. Given the ubiquity of assortative
    mating in nature, why and how it has evolved remain open questions. Here we attempt
    to answer these questions in those cases where the trait under assortment is the
    same in males and females. We consider the most favorable scenario for assortment
    to evolve, where the same trait is under assortment and viability selection. We
    find conditions for assortment to evolve using a multilocus formalism in a haploid
    population. Our results show how epistasis in fitness between the loci that control
    the focal trait is crucial for assortment to evolve. We then assume specific forms
    of assortment in haploids and diploids and study the limiting cases of selective
    and nonselective mating. We find that selection for increased assortment is weak
    and that where increased assortment is costly, it does not invade.
author:
- first_name: Maria
  full_name: De Cara, Maria A
  last_name: De Cara
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Mark
  full_name: Kirkpatrick, Mark
  last_name: Kirkpatrick
citation:
  ama: De Cara M, Barton NH, Kirkpatrick M. A model for the evolution of assortative
    mating. <i>American Naturalist</i>. 2008;171(5):580-596. doi:<a href="https://doi.org/10.1086/587062">10.1086/587062</a>
  apa: De Cara, M., Barton, N. H., &#38; Kirkpatrick, M. (2008). A model for the evolution
    of assortative mating. <i>American Naturalist</i>. University of Chicago Press.
    <a href="https://doi.org/10.1086/587062">https://doi.org/10.1086/587062</a>
  chicago: De Cara, Maria, Nicholas H Barton, and Mark Kirkpatrick. “A Model for the
    Evolution of Assortative Mating.” <i>American Naturalist</i>. University of Chicago
    Press, 2008. <a href="https://doi.org/10.1086/587062">https://doi.org/10.1086/587062</a>.
  ieee: M. De Cara, N. H. Barton, and M. Kirkpatrick, “A model for the evolution of
    assortative mating,” <i>American Naturalist</i>, vol. 171, no. 5. University of
    Chicago Press, pp. 580–596, 2008.
  ista: De Cara M, Barton NH, Kirkpatrick M. 2008. A model for the evolution of assortative
    mating. American Naturalist. 171(5), 580–596.
  mla: De Cara, Maria, et al. “A Model for the Evolution of Assortative Mating.” <i>American
    Naturalist</i>, vol. 171, no. 5, University of Chicago Press, 2008, pp. 580–96,
    doi:<a href="https://doi.org/10.1086/587062">10.1086/587062</a>.
  short: M. De Cara, N.H. Barton, M. Kirkpatrick, American Naturalist 171 (2008) 580–596.
date_created: 2018-12-11T12:04:12Z
date_published: 2008-05-01T00:00:00Z
date_updated: 2021-01-12T07:44:36Z
day: '01'
doi: 10.1086/587062
extern: 1
intvolume: '       171'
issue: '5'
month: '05'
page: 580 - 596
publication: American Naturalist
publication_status: published
publisher: University of Chicago Press
publist_id: '2778'
quality_controlled: 0
status: public
title: A model for the evolution of assortative mating
type: journal_article
volume: 171
year: '2008'
...
---
_id: '3606'
abstract:
- lang: eng
  text: 'Explicit formulae are given for the effects of a barrier to gene flow on
    random fluctuations in allele frequency; these formulae can also be seen as generating
    functions for the distribution of coalescence times. The formulae are derived
    using a continuous diffusion approximation, which is accurate over all but very
    small spatial scales. The continuous approximation is confirmed by comparison
    with the exact solution to the stepping stone model. In both one and two spatial
    dimensions, the variance of fluctuations in allele frequencies increases near
    the barrier; when the barrier is very strong, the variance doubles. However, the
    effect on fluctuations close to the barrier is much greater when the population
    is spread over two spatial dimensions than when it occupies a linear, one-dimensional
    habitat: barriers of strength comparable with the dispersal range (B≈σ) can have
    an appreciable effect in two dimensions, whereas only barriers with strength comparable
    with the characteristic scale (B\! \approx\! L \equals \sigma \sol \sqrt {2 \mu}\hskip2)
    are significant in one dimension (μ is the rate of mutation or long-range dispersal).
    Thus, in a two-dimensional population, barriers to gene flow can be detected through
    their effect on the spatial pattern of genetic marker alleles.'
author:
- first_name: Nicholas H
  full_name: Nicholas Barton
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. The effect of a barrier to gene flow on patterns of geographic variation.
    <i>Genetical Research</i>. 2008;90(1):139-149. doi:<a href="https://doi.org/10.1017/S0016672307009081">10.1017/S0016672307009081</a>
  apa: Barton, N. H. (2008). The effect of a barrier to gene flow on patterns of geographic
    variation. <i>Genetical Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672307009081">https://doi.org/10.1017/S0016672307009081</a>
  chicago: Barton, Nicholas H. “The Effect of a Barrier to Gene Flow on Patterns of
    Geographic Variation.” <i>Genetical Research</i>. Cambridge University Press,
    2008. <a href="https://doi.org/10.1017/S0016672307009081">https://doi.org/10.1017/S0016672307009081</a>.
  ieee: N. H. Barton, “The effect of a barrier to gene flow on patterns of geographic
    variation,” <i>Genetical Research</i>, vol. 90, no. 1. Cambridge University Press,
    pp. 139–149, 2008.
  ista: Barton NH. 2008. The effect of a barrier to gene flow on patterns of geographic
    variation. Genetical Research. 90(1), 139–149.
  mla: Barton, Nicholas H. “The Effect of a Barrier to Gene Flow on Patterns of Geographic
    Variation.” <i>Genetical Research</i>, vol. 90, no. 1, Cambridge University Press,
    2008, pp. 139–49, doi:<a href="https://doi.org/10.1017/S0016672307009081">10.1017/S0016672307009081</a>.
  short: N.H. Barton, Genetical Research 90 (2008) 139–149.
date_created: 2018-12-11T12:04:12Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:37Z
day: '01'
doi: 10.1017/S0016672307009081
extern: 1
intvolume: '        90'
issue: '1'
month: '02'
page: 139 - 149
publication: Genetical Research
publication_status: published
publisher: Cambridge University Press
publist_id: '2777'
quality_controlled: 0
status: public
title: The effect of a barrier to gene flow on patterns of geographic variation
type: journal_article
volume: 90
year: '2008'
...
---
_id: '3694'
abstract:
- lang: eng
  text: Distributed Denial of Service (DDoS) attacks are today the most destabilizing
    factor in the global internet and there is a strong need for sophisticated solutions.
    We introduce a formal statistical framework and derive a Bayes optimal packet
    classifier from it. Our proposed practical algorithm &quot;Adaptive History-Based
    IP Filtering&quot; (AHIF) mitigates DDoS attacks near the victim and outperforms
    existing methods by at least 32% in terms of collateral damage. Furthermore, it
    adjusts to the strength of an ongoing attack and ensures availability of the attacked
    server. In contrast to other adaptive solutions, firewall rulesets used to resist
    an attack can be precalculated before an attack takes place. This ensures an immediate
    response in a DDoS emergency. For evaluation, simulated DDoS attacks and two real-world
    user traffic datasets are used.
author:
- first_name: Markus
  full_name: Goldstein,Markus
  last_name: Goldstein
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Matthias
  full_name: Reif,Matthias
  last_name: Reif
- first_name: Armin
  full_name: Stahl,Armin
  last_name: Stahl
- first_name: Thomas
  full_name: Breuel,Thomas M
  last_name: Breuel
citation:
  ama: 'Goldstein M, Lampert C, Reif M, Stahl A, Breuel T. Bayes optimal DDoS mitigation
    by adaptive history-based IP filtering. In: IEEE; 2008:174-179. doi:<a href="https://doi.org/10.1109/ICN.2008.64">10.1109/ICN.2008.64</a>'
  apa: 'Goldstein, M., Lampert, C., Reif, M., Stahl, A., &#38; Breuel, T. (2008).
    Bayes optimal DDoS mitigation by adaptive history-based IP filtering (pp. 174–179).
    Presented at the ICN: International Conference on Networking, IEEE. <a href="https://doi.org/10.1109/ICN.2008.64">https://doi.org/10.1109/ICN.2008.64</a>'
  chicago: Goldstein, Markus, Christoph Lampert, Matthias Reif, Armin Stahl, and Thomas
    Breuel. “Bayes Optimal DDoS Mitigation by Adaptive History-Based IP Filtering,”
    174–79. IEEE, 2008. <a href="https://doi.org/10.1109/ICN.2008.64">https://doi.org/10.1109/ICN.2008.64</a>.
  ieee: 'M. Goldstein, C. Lampert, M. Reif, A. Stahl, and T. Breuel, “Bayes optimal
    DDoS mitigation by adaptive history-based IP filtering,” presented at the ICN:
    International Conference on Networking, 2008, pp. 174–179.'
  ista: 'Goldstein M, Lampert C, Reif M, Stahl A, Breuel T. 2008. Bayes optimal DDoS
    mitigation by adaptive history-based IP filtering. ICN: International Conference
    on Networking, 174–179.'
  mla: Goldstein, Markus, et al. <i>Bayes Optimal DDoS Mitigation by Adaptive History-Based
    IP Filtering</i>. IEEE, 2008, pp. 174–79, doi:<a href="https://doi.org/10.1109/ICN.2008.64">10.1109/ICN.2008.64</a>.
  short: M. Goldstein, C. Lampert, M. Reif, A. Stahl, T. Breuel, in:, IEEE, 2008,
    pp. 174–179.
conference:
  name: 'ICN: International Conference on Networking'
date_created: 2018-12-11T12:04:39Z
date_published: 2008-04-13T00:00:00Z
date_updated: 2021-01-12T07:49:01Z
day: '13'
doi: 10.1109/ICN.2008.64
extern: 1
main_file_link:
- open_access: '0'
  url: http://pub.ist.ac.at/~chl/papers/goldstein-icn2008.pdf
month: '04'
page: 174 - 179
publication_status: published
publisher: IEEE
publist_id: '2671'
quality_controlled: 0
status: public
title: Bayes optimal DDoS mitigation by adaptive history-based IP filtering
type: conference
year: '2008'
...
---
_id: '3698'
abstract:
- lang: eng
  text: Kernel canonical correlation analysis (KCCA) is a dimensionality reduction
    technique for paired data. By finding directions that maximize correlation, KCCA
    learns representations that are more closely tied to the underlying semantics
    of the data rather than noise. However, meaningful directions are not only those
    that have high correlation to another modality, but also those that capture the
    manifold structure of the data. We propose a method that is simultaneously able
    to find highly correlated directions that are also located on high variance directions
    along the data manifold. This is achieved by the use of semi-supervised Laplacian
    regularization of KCCA. We show experimentally that Laplacian regularized training
    improves class separation over KCCA with only Tikhonov regularization, while causing
    no degradation in the correlation between modalities. We propose a model selection
    criterion based on the Hilbert-Schmidt norm of the semi-supervised Laplacian regularized
    cross-covariance operator, which we compute in closed form.
alternative_title:
- LNCS
author:
- first_name: Matthew
  full_name: Blaschko,Matthew B
  last_name: Blaschko
- first_name: Christoph
  full_name: Christoph Lampert
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
- first_name: Arthur
  full_name: Gretton,Arthur
  last_name: Gretton
citation:
  ama: 'Blaschko M, Lampert C, Gretton A. Semi-supervised Laplacian regularization
    of kernel canonical correlation analysis. In: Vol 5211. Springer; 2008:133-145.
    doi:<a href="https://doi.org/10.1007/978-3-540-87479-9_27">10.1007/978-3-540-87479-9_27</a>'
  apa: 'Blaschko, M., Lampert, C., &#38; Gretton, A. (2008). Semi-supervised Laplacian
    regularization of kernel canonical correlation analysis (Vol. 5211, pp. 133–145).
    Presented at the ECML: European Conference on Machine Learning, Springer. <a href="https://doi.org/10.1007/978-3-540-87479-9_27">https://doi.org/10.1007/978-3-540-87479-9_27</a>'
  chicago: Blaschko, Matthew, Christoph Lampert, and Arthur Gretton. “Semi-Supervised
    Laplacian Regularization of Kernel Canonical Correlation Analysis,” 5211:133–45.
    Springer, 2008. <a href="https://doi.org/10.1007/978-3-540-87479-9_27">https://doi.org/10.1007/978-3-540-87479-9_27</a>.
  ieee: 'M. Blaschko, C. Lampert, and A. Gretton, “Semi-supervised Laplacian regularization
    of kernel canonical correlation analysis,” presented at the ECML: European Conference
    on Machine Learning, 2008, vol. 5211, no. Part 1, pp. 133–145.'
  ista: 'Blaschko M, Lampert C, Gretton A. 2008. Semi-supervised Laplacian regularization
    of kernel canonical correlation analysis. ECML: European Conference on Machine
    Learning, LNCS, vol. 5211, 133–145.'
  mla: Blaschko, Matthew, et al. <i>Semi-Supervised Laplacian Regularization of Kernel
    Canonical Correlation Analysis</i>. Vol. 5211, no. Part 1, Springer, 2008, pp.
    133–45, doi:<a href="https://doi.org/10.1007/978-3-540-87479-9_27">10.1007/978-3-540-87479-9_27</a>.
  short: M. Blaschko, C. Lampert, A. Gretton, in:, Springer, 2008, pp. 133–145.
conference:
  name: 'ECML: European Conference on Machine Learning'
date_created: 2018-12-11T12:04:41Z
date_published: 2008-10-21T00:00:00Z
date_updated: 2021-01-12T07:49:02Z
day: '21'
doi: 10.1007/978-3-540-87479-9_27
extern: 1
intvolume: '      5211'
issue: Part 1
month: '10'
page: 133 - 145
publication_status: published
publisher: Springer
publist_id: '2662'
quality_controlled: 0
status: public
title: Semi-supervised Laplacian regularization of kernel canonical correlation analysis
type: conference
volume: 5211
year: '2008'
...
