---
_id: '2498'
abstract:
- lang: eng
text: Activation of G protein-gated inwardly-rectifying K+ (GIRK or Kir3) channels
by metabotropic gamma-aminobutyric acid (B) (GABAB) receptors is an essential
signalling pathway controlling neuronal excitability and synaptic transmission
in the brain. To investigate the relationship between GIRK channel subunits and
GABAB receptors in cerebellar Purkinje cells at post- and pre-synaptic sites,
we used biochemical, functional and immunohistochemical techniques. Co-immunoprecipitation
analysis demonstrated that GIRK subunits are co-assembled with GABAB receptors
in the cerebellum. Immunoelectron microscopy showed that the subunit composition
of GIRK channels in Purkinje cell spines is compartment-dependent. Thus, at extrasynaptic
sites GIRK channels are formed by GIRK1/GIRK2/GIRK3, post-synaptic densities contain
GIRK2/GIRK3 and dendritic shafts contain GIRK1/GIRK3. The post-synaptic association
of GIRK subunits with GABAB receptors in Purkinje cells is supported by the subcellular
regulation of the ion channel and the receptor in mutant mice. At pre-synaptic
sites, GIRK channels localized to parallel fibre terminals are formed by GIRK1/GIRK2/GIRK3
and co-localize with GABAB receptors. Consistent with this morphological evidence
we demonstrate their functional interaction at axon terminals in the cerebellum
by showing that GIRK channels play a role in the inhibition of glutamate release
by GABAB receptors. The association of GIRK channels and GABA B receptors with
excitatory synapses at both post- and pre-synaptic sites indicates their intimate
involvement in the modulation of glutamatergic neurotransmission in the cerebellum.
author:
- first_name: Laura
full_name: Fernández-Alacid, Laura
last_name: Fernández Alacid
- first_name: Carolina
full_name: Aguado, Carolina
last_name: Aguado
- first_name: Francisco
full_name: Ciruela, Francisco
last_name: Ciruela
- first_name: Ricardo
full_name: Martín, Ricardo J
last_name: Martín
- first_name: José
full_name: Colón, José
last_name: Colón
- first_name: María
full_name: Cabañero, María José
last_name: Cabañero
- first_name: Martin
full_name: Gassmann, Martin
last_name: Gassmann
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kevin
full_name: Wickman, Kevin D
last_name: Wickman
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: José
full_name: Sánchez-Prieto, José
last_name: Sánchez Prieto
- first_name: Rafael
full_name: Luján, Rafael
last_name: Luján
citation:
ama: Fernández Alacid L, Aguado C, Ciruela F, et al. Subcellular compartment-specific
molecular diversity of pre- and post-synaptic GABAB-activated GIRK channels in
Purkinje cells. Journal of Neurochemistry. 2009;110(4):1363-1376. doi:10.1111/j.1471-4159.2009.06229.x
apa: Fernández Alacid, L., Aguado, C., Ciruela, F., Martín, R., Colón, J., Cabañero,
M., … Luján, R. (2009). Subcellular compartment-specific molecular diversity
of pre- and post-synaptic GABAB-activated GIRK channels in Purkinje cells. Journal
of Neurochemistry. Wiley-Blackwell. https://doi.org/10.1111/j.1471-4159.2009.06229.x
chicago: Fernández Alacid, Laura, Carolina Aguado, Francisco Ciruela, Ricardo Martín,
José Colón, María Cabañero, Martin Gassmann, et al. “ Subcellular Compartment-Specific
Molecular Diversity of Pre- and Post-Synaptic GABAB-Activated GIRK Channels in
Purkinje Cells.” Journal of Neurochemistry. Wiley-Blackwell, 2009. https://doi.org/10.1111/j.1471-4159.2009.06229.x.
ieee: L. Fernández Alacid et al., “ Subcellular compartment-specific molecular
diversity of pre- and post-synaptic GABAB-activated GIRK channels in Purkinje
cells,” Journal of Neurochemistry, vol. 110, no. 4. Wiley-Blackwell, pp.
1363–1376, 2009.
ista: Fernández Alacid L, Aguado C, Ciruela F, Martín R, Colón J, Cabañero M, Gassmann
M, Watanabe M, Shigemoto R, Wickman K, Bettler B, Sánchez Prieto J, Luján R. 2009. Subcellular
compartment-specific molecular diversity of pre- and post-synaptic GABAB-activated
GIRK channels in Purkinje cells. Journal of Neurochemistry. 110(4), 1363–1376.
mla: Fernández Alacid, Laura, et al. “ Subcellular Compartment-Specific Molecular
Diversity of Pre- and Post-Synaptic GABAB-Activated GIRK Channels in Purkinje
Cells.” Journal of Neurochemistry, vol. 110, no. 4, Wiley-Blackwell, 2009,
pp. 1363–76, doi:10.1111/j.1471-4159.2009.06229.x.
short: L. Fernández Alacid, C. Aguado, F. Ciruela, R. Martín, J. Colón, M. Cabañero,
M. Gassmann, M. Watanabe, R. Shigemoto, K. Wickman, B. Bettler, J. Sánchez Prieto,
R. Luján, Journal of Neurochemistry 110 (2009) 1363–1376.
date_created: 2018-12-11T11:58:01Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2021-01-12T06:57:50Z
day: '01'
doi: 10.1111/j.1471-4159.2009.06229.x
extern: 1
intvolume: ' 110'
issue: '4'
month: '08'
page: 1363 - 1376
publication: Journal of Neurochemistry
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4403'
quality_controlled: 0
status: public
title: ' Subcellular compartment-specific molecular diversity of pre- and post-synaptic
GABAB-activated GIRK channels in Purkinje cells'
type: journal_article
volume: 110
year: '2009'
...
---
_id: '2499'
abstract:
- lang: eng
text: G protein-coupled receptors (GPCRs) have critical functions in intercellular
communication. Although a wide range of different receptors have been identified
in the same cells, the mechanism by which signals are integrated remains elusive.
The ability of GPCRs to form dimers or larger hetero-oligomers is thought to generate
such signal integration. We examined the molecular mechanisms responsible for
the GABAB receptor-mediated potentiation of the mGlu receptor signalling reported
in Purkinje neurons. We showed that this effect does not require a physical interaction
between both receptors. Instead, it is the result of a more general mechanism
in which the βγ subunits produced by the Gi-coupled GABAB receptor enhance the
mGlu-mediated Gq response. Most importantly, this mechanism could be generally
applied to other pairs of Gi- and Gq-coupled receptors and the signal integration
varied depending on the time delay between activation of each receptor. Such a
mechanism helps explain specific properties of cells expressing two different
Gi- and Gq-coupled receptors activated by a single transmitter, or properties
of GPCRs naturally coupled to both types of the G protein.
author:
- first_name: Marie
full_name: Rives, Marie L
last_name: Rives
- first_name: Claire
full_name: Vol, Claire
last_name: Vol
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Norbert
full_name: Tinel, Norbert
last_name: Tinel
- first_name: Eric
full_name: Trinquet, Eric
last_name: Trinquet
- first_name: Mohammed
full_name: Ayoub, Mohammed A
last_name: Ayoub
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Jean
full_name: Pin, Jean-Philippe
last_name: Pin
- first_name: Laurent
full_name: Prezèau, Laurent
last_name: Prezèau
citation:
ama: Rives M, Vol C, Fukazawa Y, et al. Crosstalk between GABAB and mGlu1a receptors
reveals new insight into GPCR signal integration. EMBO Journal. 2009;28(15):2195-2208.
doi:10.1038/emboj.2009.177
apa: Rives, M., Vol, C., Fukazawa, Y., Tinel, N., Trinquet, E., Ayoub, M., … Prezèau,
L. (2009). Crosstalk between GABAB and mGlu1a receptors reveals new insight into
GPCR signal integration. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1038/emboj.2009.177
chicago: Rives, Marie, Claire Vol, Yugo Fukazawa, Norbert Tinel, Eric Trinquet,
Mohammed Ayoub, Ryuichi Shigemoto, Jean Pin, and Laurent Prezèau. “Crosstalk between
GABAB and MGlu1a Receptors Reveals New Insight into GPCR Signal Integration.”
EMBO Journal. Wiley-Blackwell, 2009. https://doi.org/10.1038/emboj.2009.177.
ieee: M. Rives et al., “Crosstalk between GABAB and mGlu1a receptors reveals
new insight into GPCR signal integration,” EMBO Journal, vol. 28, no. 15.
Wiley-Blackwell, pp. 2195–2208, 2009.
ista: Rives M, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub M, Shigemoto R, Pin
J, Prezèau L. 2009. Crosstalk between GABAB and mGlu1a receptors reveals new insight
into GPCR signal integration. EMBO Journal. 28(15), 2195–2208.
mla: Rives, Marie, et al. “Crosstalk between GABAB and MGlu1a Receptors Reveals
New Insight into GPCR Signal Integration.” EMBO Journal, vol. 28, no. 15,
Wiley-Blackwell, 2009, pp. 2195–208, doi:10.1038/emboj.2009.177.
short: M. Rives, C. Vol, Y. Fukazawa, N. Tinel, E. Trinquet, M. Ayoub, R. Shigemoto,
J. Pin, L. Prezèau, EMBO Journal 28 (2009) 2195–2208.
date_created: 2018-12-11T11:58:01Z
date_published: 2009-08-15T00:00:00Z
date_updated: 2021-01-12T06:57:51Z
day: '15'
doi: 10.1038/emboj.2009.177
extern: 1
intvolume: ' 28'
issue: '15'
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726695/
month: '08'
oa: 1
page: 2195 - 2208
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4402'
quality_controlled: 0
status: public
title: Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR
signal integration
type: journal_article
volume: 28
year: '2009'
...
---
_id: '2500'
abstract:
- lang: eng
text: 'To examine the intrasynaptic arrangement of postsynaptic receptors in relation
to the functional role of the synapse,we quantitatively analyzed the two-dimensional
distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using
SDS-digested freeze-fracture replica labeling (SDS-FRL) and assessed the implication
of distribution differences on the postsynaptic responses by simulation. In the
dorsal lateral geniculate nucleus, corticogeniculate (CG) synapses were twice
as large as retinogeniculate (RG) synapses but expressed similar numbers of AMPARs.
Two-dimensional views of replicas revealed that AMPARs form microclusters in both
synapses to a similar extent, resulting in larger AMPAR-lacking areas in the CG
synapses. Despite the broad difference in the AMPAR distribution within a synapse,
our simulations based on the actual receptor distributions suggested that the
AMPAR quantal response at individual RG synapses is only slightly larger in amplitude,
less variable, and faster in kinetics than that at CG synapses having a similar
number of the receptors. NMDARs at the CG synapses were expressed twice as many
as those in the RG synapses. Electrophysiological recordings confirmed a larger
contribution of NMDAR relative to AMPAR-mediated responses in CG synapses. We
conclude that synapse size and the density and distribution of receptors have
minor influences on quantal responses and that the number of receptors acts as
a predominant postsynaptic determinant of the synaptic strength mediated by both
the AMPARs and NMDARs. '
author:
- first_name: Etsuko
full_name: Tarusawa, Etsuko
last_name: Tarusawa
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Timotheus
full_name: Budisantoso, Timotheus
last_name: Budisantoso
- first_name: Elek
full_name: Molnár, Elek
last_name: Molnár
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Minoru
full_name: Matsui, Minoru
last_name: Matsui
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Tarusawa E, Matsui K, Budisantoso T, et al. Input-specific intrasynaptic arrangements
of ionotropic glutamate receptors and their impact on postsynaptic responses.
Journal of Neuroscience. 2009;29(41):12896-12908. doi:10.1523/JNEUROSCI.6160-08.2009
apa: Tarusawa, E., Matsui, K., Budisantoso, T., Molnár, E., Watanabe, M., Matsui,
M., … Shigemoto, R. (2009). Input-specific intrasynaptic arrangements of ionotropic
glutamate receptors and their impact on postsynaptic responses. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.6160-08.2009
chicago: Tarusawa, Etsuko, Ko Matsui, Timotheus Budisantoso, Elek Molnár, Masahiko
Watanabe, Minoru Matsui, Yugo Fukazawa, and Ryuichi Shigemoto. “Input-Specific
Intrasynaptic Arrangements of Ionotropic Glutamate Receptors and Their Impact
on Postsynaptic Responses.” Journal of Neuroscience. Society for Neuroscience,
2009. https://doi.org/10.1523/JNEUROSCI.6160-08.2009.
ieee: E. Tarusawa et al., “Input-specific intrasynaptic arrangements of ionotropic
glutamate receptors and their impact on postsynaptic responses,” Journal of
Neuroscience, vol. 29, no. 41. Society for Neuroscience, pp. 12896–12908,
2009.
ista: Tarusawa E, Matsui K, Budisantoso T, Molnár E, Watanabe M, Matsui M, Fukazawa
Y, Shigemoto R. 2009. Input-specific intrasynaptic arrangements of ionotropic
glutamate receptors and their impact on postsynaptic responses. Journal of Neuroscience.
29(41), 12896–12908.
mla: Tarusawa, Etsuko, et al. “Input-Specific Intrasynaptic Arrangements of Ionotropic
Glutamate Receptors and Their Impact on Postsynaptic Responses.” Journal of
Neuroscience, vol. 29, no. 41, Society for Neuroscience, 2009, pp. 12896–908,
doi:10.1523/JNEUROSCI.6160-08.2009.
short: E. Tarusawa, K. Matsui, T. Budisantoso, E. Molnár, M. Watanabe, M. Matsui,
Y. Fukazawa, R. Shigemoto, Journal of Neuroscience 29 (2009) 12896–12908.
date_created: 2018-12-11T11:58:02Z
date_published: 2009-10-14T00:00:00Z
date_updated: 2021-01-12T06:57:52Z
day: '14'
doi: 10.1523/JNEUROSCI.6160-08.2009
extern: 1
intvolume: ' 29'
issue: '41'
month: '10'
page: 12896 - 12908
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4401'
quality_controlled: 0
status: public
title: Input-specific intrasynaptic arrangements of ionotropic glutamate receptors
and their impact on postsynaptic responses
type: journal_article
volume: 29
year: '2009'
...
---
_id: '2501'
abstract:
- lang: eng
text: The brain-specific immediate early gene Arc/Arg3.1 is induced in response
to a variety of stimuli, including sensory and behavior-linked neural activity.
Here we report the generation of transgenic mice, termed TgArc/Arg3.1-d4EGFP,
expressing a 4-h half-life form of enhanced green fluorescent protein (d4EGFP)
under the control of the Arc/Arg3.1 promoter. We show that d4EGFP-mediated fluorescence
faithfully reports Arc/Arg3.1 induction in response to physiological, pathological
and pharmacological stimuli, and that this fluorescence permits electrical recording
from activated neurons in the live mouse. Moreover, the fluorescent Arc/Arg3.1
indicator revealed activity changes in circumscribed brain areas in distinct modes
of stress and in a mouse model of Alzheimer's disease. These findings identify
the TgArc/Arg3.1-d4EGFP mouse as a versatile tool to monitor Arc/Arg3.1 induction
in neural circuits, both in vitro and in vivo.
author:
- first_name: Valery
full_name: Grinevich, Valery V
last_name: Grinevich
- first_name: Alexander
full_name: Kolleker, Alexander
last_name: Kolleker
- first_name: Marina
full_name: Eliava, Marina I
last_name: Eliava
- first_name: Naoki
full_name: Takada, Naoki
last_name: Takada
- first_name: Hiroshi
full_name: Takuma, Hiroshi
last_name: Takuma
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Dietmar
full_name: Kuhl, Dietmar
last_name: Kuhl
- first_name: Jack
full_name: Waters, Jack
last_name: Waters
- first_name: Peter
full_name: Seeburg, Peter H
last_name: Seeburg
- first_name: Pavel
full_name: Osten, Pavel
last_name: Osten
citation:
ama: 'Grinevich V, Kolleker A, Eliava M, et al. Fluorescent Arc/Arg3.1 indicator
mice: A versatile tool to study brain activity changes in vitro and in vivo. Journal
of Neuroscience Methods. 2009;184(1):25-36. doi:10.1016/j.jneumeth.2009.07.015'
apa: 'Grinevich, V., Kolleker, A., Eliava, M., Takada, N., Takuma, H., Fukazawa,
Y., … Osten, P. (2009). Fluorescent Arc/Arg3.1 indicator mice: A versatile tool
to study brain activity changes in vitro and in vivo. Journal of Neuroscience
Methods. Elsevier. https://doi.org/10.1016/j.jneumeth.2009.07.015'
chicago: 'Grinevich, Valery, Alexander Kolleker, Marina Eliava, Naoki Takada, Hiroshi
Takuma, Yugo Fukazawa, Ryuichi Shigemoto, et al. “Fluorescent Arc/Arg3.1 Indicator
Mice: A Versatile Tool to Study Brain Activity Changes in Vitro and in Vivo.”
Journal of Neuroscience Methods. Elsevier, 2009. https://doi.org/10.1016/j.jneumeth.2009.07.015.'
ieee: 'V. Grinevich et al., “Fluorescent Arc/Arg3.1 indicator mice: A versatile
tool to study brain activity changes in vitro and in vivo,” Journal of Neuroscience
Methods, vol. 184, no. 1. Elsevier, pp. 25–36, 2009.'
ista: 'Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazawa Y, Shigemoto
R, Kuhl D, Waters J, Seeburg P, Osten P. 2009. Fluorescent Arc/Arg3.1 indicator
mice: A versatile tool to study brain activity changes in vitro and in vivo. Journal
of Neuroscience Methods. 184(1), 25–36.'
mla: 'Grinevich, Valery, et al. “Fluorescent Arc/Arg3.1 Indicator Mice: A Versatile
Tool to Study Brain Activity Changes in Vitro and in Vivo.” Journal of Neuroscience
Methods, vol. 184, no. 1, Elsevier, 2009, pp. 25–36, doi:10.1016/j.jneumeth.2009.07.015.'
short: V. Grinevich, A. Kolleker, M. Eliava, N. Takada, H. Takuma, Y. Fukazawa,
R. Shigemoto, D. Kuhl, J. Waters, P. Seeburg, P. Osten, Journal of Neuroscience
Methods 184 (2009) 25–36.
date_created: 2018-12-11T11:58:02Z
date_published: 2009-10-30T00:00:00Z
date_updated: 2021-01-12T06:57:52Z
day: '30'
doi: 10.1016/j.jneumeth.2009.07.015
extern: 1
intvolume: ' 184'
issue: '1'
month: '10'
page: 25 - 36
publication: Journal of Neuroscience Methods
publication_status: published
publisher: Elsevier
publist_id: '4400'
quality_controlled: 0
status: public
title: 'Fluorescent Arc/Arg3.1 indicator mice: A versatile tool to study brain activity
changes in vitro and in vivo'
type: journal_article
volume: 184
year: '2009'
...
---
_id: '2502'
abstract:
- lang: eng
text: In order to acquire phase-contrast images with adequate contrast, conventional
TEM requires large amount of defocus. Increasing the defocus improves the low-frequency
components but attenuates the high-frequency ones. On the other hand, Zernike
phase-contrast TEM (ZPC-TEM) can recover low-frequency components without losing
the high-frequency ones under in-focus conditions. ZPC-TEM however, has another
problem, especially in imaging of complex biological specimens such as cells and
tissues; strong halos appear around specimen structures, and these halos hinder
the interpretation of images. Due to this problem, the application of ZPC-TEM
has been restricted to imaging of smaller particles. In order to improve the halo
appearance, we fabricated a new quarter-wave thin film phase-plate with a smaller
central hole and tested it on vitreous biological specimens. ZPC-TEM with the
new plate could successfully visualize, in in-focus images, the intracellular
fine features of cultured cells and brain tissues. This result indicates that
reduction of the central hole diameter makes ZPC-TEM applicable on size scales
ranging from protein particles to tissue sections. The application of ZPC-TEM
to vitreous biological specimens will be a powerful method to advance the new
field of imaging science for ultrastructures in close-to-physiological state.
author:
- first_name: Yoshiyuki
full_name: Fukuda, Yoshiyuki
last_name: Fukuda
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Radostin
full_name: Danev, Radostin S
last_name: Danev
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kuniaki
full_name: Nagayama, Kuniaki
last_name: Nagayama
citation:
ama: Fukuda Y, Fukazawa Y, Danev R, Shigemoto R, Nagayama K. Tuning of the Zernike
phase-plate for visualization of detailed ultrastructure in complex biological
specimens. Journal of Structural Biology. 2009;168(3):476-484. doi:10.1016/j.jsb.2009.08.011
apa: Fukuda, Y., Fukazawa, Y., Danev, R., Shigemoto, R., & Nagayama, K. (2009).
Tuning of the Zernike phase-plate for visualization of detailed ultrastructure
in complex biological specimens. Journal of Structural Biology. Academic
Press. https://doi.org/10.1016/j.jsb.2009.08.011
chicago: Fukuda, Yoshiyuki, Yugo Fukazawa, Radostin Danev, Ryuichi Shigemoto, and
Kuniaki Nagayama. “Tuning of the Zernike Phase-Plate for Visualization of Detailed
Ultrastructure in Complex Biological Specimens.” Journal of Structural Biology.
Academic Press, 2009. https://doi.org/10.1016/j.jsb.2009.08.011.
ieee: Y. Fukuda, Y. Fukazawa, R. Danev, R. Shigemoto, and K. Nagayama, “Tuning of
the Zernike phase-plate for visualization of detailed ultrastructure in complex
biological specimens,” Journal of Structural Biology, vol. 168, no. 3.
Academic Press, pp. 476–484, 2009.
ista: Fukuda Y, Fukazawa Y, Danev R, Shigemoto R, Nagayama K. 2009. Tuning of the
Zernike phase-plate for visualization of detailed ultrastructure in complex biological
specimens. Journal of Structural Biology. 168(3), 476–484.
mla: Fukuda, Yoshiyuki, et al. “Tuning of the Zernike Phase-Plate for Visualization
of Detailed Ultrastructure in Complex Biological Specimens.” Journal of Structural
Biology, vol. 168, no. 3, Academic Press, 2009, pp. 476–84, doi:10.1016/j.jsb.2009.08.011.
short: Y. Fukuda, Y. Fukazawa, R. Danev, R. Shigemoto, K. Nagayama, Journal of Structural
Biology 168 (2009) 476–484.
date_created: 2018-12-11T11:58:03Z
date_published: 2009-12-01T00:00:00Z
date_updated: 2021-01-12T06:57:52Z
day: '01'
doi: 10.1016/j.jsb.2009.08.011
extern: 1
intvolume: ' 168'
issue: '3'
month: '12'
page: 476 - 484
publication: Journal of Structural Biology
publication_status: published
publisher: Academic Press
publist_id: '4399'
quality_controlled: 0
status: public
title: Tuning of the Zernike phase-plate for visualization of detailed ultrastructure
in complex biological specimens
type: journal_article
volume: 168
year: '2009'
...
---
_id: '2680'
abstract:
- lang: eng
text: 'GABA B receptor subtypes are based on the subunit isoforms GABA B1a and GABA
B1b, which associate with GABA B2 subunits to form pharmacologically indistinguishable
GABA B(1a,2) and GABA B(1b,2) receptors. Studies with mice selectively expressing
GABA B1a or GABA B1b subunits revealed that GABA B(1a,2) receptors are more abundant
than GABA B(1b,2) receptors at glutamatergic terminals. Accordingly, it was found
that GABA B(1a,2) receptors are more efficient than GABA B(1b,2) receptors in
inhibiting glutamate release when maximally activated by exogenous application
of the agonist baclofen. Here, we used a combination of genetic, ultrastructural
and electrophysiological approaches to analyze to what extent GABA B(1a,2) and
GABA B(1b,2) receptors inhibit glutamate release in response to physiological
activation. We first show that at hippocampal mossy fiber (MF)-CA3 pyramidal neuron
synapses more GABA B1a than GABA B1b protein is present at presynaptic sites,
consistent with the findings at other glutamatergic synapses. In the presence
of baclofen at concentrations ≥1 μM, both GABA B(1a,2) and GABA B(1b,2) receptors
contribute to presynaptic inhibition of glutamate release. However, at lower concentrations
of baclofen, selectively GABA B(1a,2) receptors contribute to presynaptic inhibition.
Remarkably, exclusively GABA B(1a,2) receptors inhibit glutamate release in response
to synaptically released GABA. Specifically, we demonstrate that selectively GABA
B(1a,2) receptors mediate heterosynaptic depression of MF transmission, a physiological
phenomenon involving transsynaptic inhibition of glutamate release via presynaptic
GABA B receptors. Our data demonstrate that the difference in GABA B1a and GABA
B1b protein levels at MF terminals is sufficient to produce a strictly GABA B1a-specific
effect under physiological conditions. This consolidates that the differential
subcellular localization of the GABA B1a and GABA B1b proteins is of regulatory
relevance. '
author:
- first_name: Nicole
full_name: Guetg, Nicole
last_name: Guetg
- first_name: Riad
full_name: Seddik, Riad
last_name: Seddik
- first_name: Réjan
full_name: Vigot, Réjan
last_name: Vigot
- first_name: Rostislav
full_name: Tureček, Rostislav
last_name: Tureček
- first_name: Martin
full_name: Gassmann, Martin
last_name: Gassmann
- first_name: Kaspar
full_name: Vogt, Kaspar E
last_name: Vogt
- first_name: Hans
full_name: Bräuner-Osborne, Hans
last_name: Bräuner Osborne
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Oliver
full_name: Kretz, Oliver
last_name: Kretz
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
citation:
ama: Guetg N, Seddik R, Vigot R, et al. The GABA B1a isoform mediates heterosynaptic
depression at hippocampal mossy fiber synapses. Journal of Neuroscience.
2009;29(5):1414-1423. doi:10.1523/JNEUROSCI.3697-08.2009
apa: Guetg, N., Seddik, R., Vigot, R., Tureček, R., Gassmann, M., Vogt, K., … Bettler,
B. (2009). The GABA B1a isoform mediates heterosynaptic depression at hippocampal
mossy fiber synapses. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.3697-08.2009
chicago: Guetg, Nicole, Riad Seddik, Réjan Vigot, Rostislav Tureček, Martin Gassmann,
Kaspar Vogt, Hans Bräuner Osborne, et al. “The GABA B1a Isoform Mediates Heterosynaptic
Depression at Hippocampal Mossy Fiber Synapses.” Journal of Neuroscience.
Society for Neuroscience, 2009. https://doi.org/10.1523/JNEUROSCI.3697-08.2009.
ieee: N. Guetg et al., “The GABA B1a isoform mediates heterosynaptic depression
at hippocampal mossy fiber synapses,” Journal of Neuroscience, vol. 29,
no. 5. Society for Neuroscience, pp. 1414–1423, 2009.
ista: Guetg N, Seddik R, Vigot R, Tureček R, Gassmann M, Vogt K, Bräuner Osborne
H, Shigemoto R, Kretz O, Frotscher M, Kulik Á, Bettler B. 2009. The GABA B1a isoform
mediates heterosynaptic depression at hippocampal mossy fiber synapses. Journal
of Neuroscience. 29(5), 1414–1423.
mla: Guetg, Nicole, et al. “The GABA B1a Isoform Mediates Heterosynaptic Depression
at Hippocampal Mossy Fiber Synapses.” Journal of Neuroscience, vol. 29,
no. 5, Society for Neuroscience, 2009, pp. 1414–23, doi:10.1523/JNEUROSCI.3697-08.2009.
short: N. Guetg, R. Seddik, R. Vigot, R. Tureček, M. Gassmann, K. Vogt, H. Bräuner
Osborne, R. Shigemoto, O. Kretz, M. Frotscher, Á. Kulik, B. Bettler, Journal of
Neuroscience 29 (2009) 1414–1423.
date_created: 2018-12-11T11:59:02Z
date_published: 2009-02-04T00:00:00Z
date_updated: 2021-01-12T06:59:01Z
day: '04'
doi: 10.1523/JNEUROSCI.3697-08.2009
extern: 1
intvolume: ' 29'
issue: '5'
month: '02'
page: 1414 - 1423
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4216'
quality_controlled: 0
status: public
title: The GABA B1a isoform mediates heterosynaptic depression at hippocampal mossy
fiber synapses
type: journal_article
volume: 29
year: '2009'
...
---
_id: '2682'
abstract:
- lang: eng
text: The living cell imaging using a two-photon microscope using gold nanoplates
and nanoparticle aggregates was demonstrated. The dimensions of the nanoplates
were determined through scanning electron microscopy (SEM) and atomic force microscopy.
The height of a 100 nm base-length nanotriangle was around 10 nm, while the height
of 300 nm base-length nanotriangle was around 12 nm. A spectrophotometer was also
used to determine the extinction spectra of gold nanoparticle colloids. Two-photon-induced
photoluminescence (TPIPL) under far-field excitation was tested for gold nanoplates
on a glass substrate using two-photon laser scanning microscopy (TPLSM). It was
observed that living-cell microscopic imaging can be carried out with TPIPL from
gold nanoplates and aggregated nanosphere. This method provided a platform for
developing tools for biological and biomedical studies.
author:
- first_name: Yuqiang
full_name: Jiang, Yuqiang
last_name: Jiang
- first_name: Noriko
full_name: Horimoto, Noriko N
last_name: Horimoto
- first_name: Kohei
full_name: Imura, Kohei
last_name: Imura
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Jiang Y, Horimoto N, Imura K, Matsui K, Shigemoto R. Bioimaging with two-photon-induced
luminescence from triangular nanoplates and nanoparticle aggregates of gold. Advanced
Materials. 2009;21(22):2309-2313. doi:10.1002/adma.200802312
apa: Jiang, Y., Horimoto, N., Imura, K., Matsui, K., & Shigemoto, R. (2009).
Bioimaging with two-photon-induced luminescence from triangular nanoplates and
nanoparticle aggregates of gold. Advanced Materials. Wiley-Blackwell. https://doi.org/10.1002/adma.200802312
chicago: Jiang, Yuqiang, Noriko Horimoto, Kohei Imura, Ko Matsui, and Ryuichi Shigemoto.
“Bioimaging with Two-Photon-Induced Luminescence from Triangular Nanoplates and
Nanoparticle Aggregates of Gold.” Advanced Materials. Wiley-Blackwell,
2009. https://doi.org/10.1002/adma.200802312.
ieee: Y. Jiang, N. Horimoto, K. Imura, K. Matsui, and R. Shigemoto, “Bioimaging
with two-photon-induced luminescence from triangular nanoplates and nanoparticle
aggregates of gold,” Advanced Materials, vol. 21, no. 22. Wiley-Blackwell,
pp. 2309–2313, 2009.
ista: Jiang Y, Horimoto N, Imura K, Matsui K, Shigemoto R. 2009. Bioimaging with
two-photon-induced luminescence from triangular nanoplates and nanoparticle aggregates
of gold. Advanced Materials. 21(22), 2309–2313.
mla: Jiang, Yuqiang, et al. “Bioimaging with Two-Photon-Induced Luminescence from
Triangular Nanoplates and Nanoparticle Aggregates of Gold.” Advanced Materials,
vol. 21, no. 22, Wiley-Blackwell, 2009, pp. 2309–13, doi:10.1002/adma.200802312.
short: Y. Jiang, N. Horimoto, K. Imura, K. Matsui, R. Shigemoto, Advanced Materials
21 (2009) 2309–2313.
date_created: 2018-12-11T11:59:02Z
date_published: 2009-06-12T00:00:00Z
date_updated: 2021-01-12T06:59:01Z
day: '12'
doi: 10.1002/adma.200802312
extern: 1
intvolume: ' 21'
issue: '22'
month: '06'
page: 2309 - 2313
publication: Advanced Materials
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4214'
quality_controlled: 0
status: public
title: Bioimaging with two-photon-induced luminescence from triangular nanoplates
and nanoparticle aggregates of gold
type: journal_article
volume: 21
year: '2009'
...
---
_id: '2683'
abstract:
- lang: eng
text: GABAb receptor (GABAbR)-mediated suppression of glutamate release is critical
for limiting glutamatergic transmission across the central nervous system (CNS).
Here we show that, upon tetanic stimulation of afferents to lateral amygdala,
presynaptic GABAbR-mediated inhibition only occurs in glutamatergic inputs to
principle neurons (PNs), not to interneurons (INs), despite the presence of GABAbR
in terminals to both types of neurons. The selectivity is caused by differential
local GABA accumulation; it requires GABA reuptake and parallels distinct spatial
distributions of presynaptic GABAbR in terminals to PNs and INs. Moreover, GABAbR-mediated
suppression of theta-burst-induced long-term potentiation (LTP) occurs only in
the inputs to PNs, not to INs. Thus, target-cell-specific control of glutamate
release by presynaptic GABAbR orchestrates the inhibitory dominance inside amygdala
and might contribute to prevention of nonadaptive defensive behaviors.
author:
- first_name: Bingxing
full_name: Pan, Bingxing
last_name: Pan
- first_name: Yu
full_name: Dong, Yu-Lin
last_name: Dong
- first_name: Wataru
full_name: Ito, Wataru
last_name: Ito
- first_name: Yuchio
full_name: Yanagawa, Yuchio
last_name: Yanagawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alexei
full_name: Morozov, Alexei A
last_name: Morozov
citation:
ama: Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. Selective gating
of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb
receptor. Neuron. 2009;61(6):917-929. doi:10.1016/j.neuron.2009.01.029
apa: Pan, B., Dong, Y., Ito, W., Yanagawa, Y., Shigemoto, R., & Morozov, A.
(2009). Selective gating of glutamatergic inputs to excitatory neurons of amygdala
by presynaptic GABAb receptor. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2009.01.029
chicago: Pan, Bingxing, Yu Dong, Wataru Ito, Yuchio Yanagawa, Ryuichi Shigemoto,
and Alexei Morozov. “Selective Gating of Glutamatergic Inputs to Excitatory Neurons
of Amygdala by Presynaptic GABAb Receptor.” Neuron. Elsevier, 2009. https://doi.org/10.1016/j.neuron.2009.01.029.
ieee: B. Pan, Y. Dong, W. Ito, Y. Yanagawa, R. Shigemoto, and A. Morozov, “Selective
gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic
GABAb receptor,” Neuron, vol. 61, no. 6. Elsevier, pp. 917–929, 2009.
ista: Pan B, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. 2009. Selective
gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic
GABAb receptor. Neuron. 61(6), 917–929.
mla: Pan, Bingxing, et al. “Selective Gating of Glutamatergic Inputs to Excitatory
Neurons of Amygdala by Presynaptic GABAb Receptor.” Neuron, vol. 61, no.
6, Elsevier, 2009, pp. 917–29, doi:10.1016/j.neuron.2009.01.029.
short: B. Pan, Y. Dong, W. Ito, Y. Yanagawa, R. Shigemoto, A. Morozov, Neuron 61
(2009) 917–929.
date_created: 2018-12-11T11:59:03Z
date_published: 2009-03-26T00:00:00Z
date_updated: 2021-01-12T06:59:02Z
day: '26'
doi: 10.1016/j.neuron.2009.01.029
extern: 1
intvolume: ' 61'
issue: '6'
month: '03'
page: 917 - 929
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '4215'
quality_controlled: 0
status: public
title: Selective gating of glutamatergic inputs to excitatory neurons of amygdala
by presynaptic GABAb receptor
type: journal_article
volume: 61
year: '2009'
...
---
_id: '2684'
abstract:
- lang: eng
text: Calcium-activated potassium channels have been shown to be critically involved
in neuronal function, but an elucidation of their detailed roles awaits identification
of the microdomains where they are located. This study was undertaken to unravel
the precise subcellular distribution of the large-conductance calcium-activated
potassium channels (called BK, KCa1.1, or Slo1) in the somatodendritic compartment
of cerebellar Purkinje cells by means of postembedding immunogold cytochemistry
and SDS-digested freeze-fracture replica labeling (SDS-FRL). We found BK channels
to be unevenly distributed over the Purkinje cell plasma membrane. At distal dendritic
compartments, BK channels were scattered over the plasma membrane of dendritic
shafts and spines but absent from postsynaptic densities. At the soma and proximal
dendrites, BK channels formed two distinct pools. One pool was scattered over
the plasma membrane, whereas the other pool was clustered in plasma membrane domains
overlying subsurface cisterns. The labeling density ratio of clustered to scattered
channels was about 60:1, established in SDS-FRL. Subsurface cisterns, also called
hypolemmal cisterns, are subcompartments of the endoplasmic reticulum likely representing
calciosomes that unload and refill Ca2+ independently. Purkinje cell subsurface
cisterns are enriched in inositol 1,4,5-triphosphate receptors that mediate the
effects of several neurotransmitters, hormones, and growth factors by releasing
Ca2+ into the cytosol, generating local Ca2+ sparks. Such increases in cytosolic
[Ca2+] may be sufficient for BK channel activation. Clustered BK channels in the
plasma membrane may thus participate in building a functional unit (plasmerosome)
with the underlying calciosome that contributes significantly to local signaling
in Purkinje cells.
author:
- first_name: Walter
full_name: Walter Kaufmann
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Yu
full_name: Kasugai, Yu
last_name: Kasugai
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Petter
full_name: Laake, Petter
last_name: Laake
- first_name: Joseph
full_name: Sexton, Joseph A
last_name: Sexton
- first_name: Peter
full_name: Ruth, Peter
last_name: Ruth
- first_name: Georg
full_name: Wietzorrek, Georg
last_name: Wietzorrek
- first_name: Hans
full_name: Knaus, Hans G
last_name: Knaus
- first_name: Johan
full_name: Storm, Johan F
last_name: Storm
- first_name: Ole
full_name: Ottersen, Ole P
last_name: Ottersen
citation:
ama: Kaufmann W, Ferraguti F, Fukazawa Y, et al. Large-conductance calcium-activated
potassium channels in Purkinje cell plasma membranes are clustered at sites of
hypolemmal microdomains. Journal of Comparative Neurology. 2009;515(2):215-230.
doi:10.1002/cne.22066
apa: Kaufmann, W., Ferraguti, F., Fukazawa, Y., Kasugai, Y., Shigemoto, R., Laake,
P., … Ottersen, O. (2009). Large-conductance calcium-activated potassium channels
in Purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains.
Journal of Comparative Neurology. Wiley-Blackwell. https://doi.org/10.1002/cne.22066
chicago: Kaufmann, Walter, Francesco Ferraguti, Yugo Fukazawa, Yu Kasugai, Ryuichi
Shigemoto, Petter Laake, Joseph Sexton, et al. “Large-Conductance Calcium-Activated
Potassium Channels in Purkinje Cell Plasma Membranes Are Clustered at Sites of
Hypolemmal Microdomains.” Journal of Comparative Neurology. Wiley-Blackwell,
2009. https://doi.org/10.1002/cne.22066.
ieee: W. Kaufmann et al., “Large-conductance calcium-activated potassium
channels in Purkinje cell plasma membranes are clustered at sites of hypolemmal
microdomains,” Journal of Comparative Neurology, vol. 515, no. 2. Wiley-Blackwell,
pp. 215–230, 2009.
ista: Kaufmann W, Ferraguti F, Fukazawa Y, Kasugai Y, Shigemoto R, Laake P, Sexton
J, Ruth P, Wietzorrek G, Knaus H, Storm J, Ottersen O. 2009. Large-conductance
calcium-activated potassium channels in Purkinje cell plasma membranes are clustered
at sites of hypolemmal microdomains. Journal of Comparative Neurology. 515(2),
215–230.
mla: Kaufmann, Walter, et al. “Large-Conductance Calcium-Activated Potassium Channels
in Purkinje Cell Plasma Membranes Are Clustered at Sites of Hypolemmal Microdomains.”
Journal of Comparative Neurology, vol. 515, no. 2, Wiley-Blackwell, 2009,
pp. 215–30, doi:10.1002/cne.22066.
short: W. Kaufmann, F. Ferraguti, Y. Fukazawa, Y. Kasugai, R. Shigemoto, P. Laake,
J. Sexton, P. Ruth, G. Wietzorrek, H. Knaus, J. Storm, O. Ottersen, Journal of
Comparative Neurology 515 (2009) 215–230.
date_created: 2018-12-11T11:59:03Z
date_published: 2009-07-10T00:00:00Z
date_updated: 2023-02-23T10:53:41Z
day: '10'
doi: 10.1002/cne.22066
extern: 1
intvolume: ' 515'
issue: '2'
month: '07'
page: 215 - 230
publication: Journal of Comparative Neurology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4212'
quality_controlled: 0
status: public
title: Large-conductance calcium-activated potassium channels in Purkinje cell plasma
membranes are clustered at sites of hypolemmal microdomains
type: journal_article
volume: 515
year: '2009'
...
---
_id: '2685'
abstract:
- lang: eng
text: Conduction velocity (CV) of myelinated axons has been shown to be regulated
by oligodendrocytes even after myelination has been completed. However, how myelinating
oligodendrocytes regulate CV, and what the significance of this regulation is
for normal brain function remain unknown. To address these questions, we analyzed
a transgenic mouse line harboring extra copies of the myelin proteolipid protein
1 (plp1) gene (plp1tg/- mice) at 2 months of age. At this stage, the plp1tg/-
mice have an unaffected myelin structure with a normally appearing ion channel
distribution, but the CV in all axonal tracts tested in the CNS is greatly reduced.
We also found decreased axonal diameters and slightly abnormal paranodal structures,
both of which can be a cause for the reduced CV. Interestingly the plp1tg/- mice
showed altered anxiety-like behaviors, reduced prepulse inhibitions, spatial learning
deficits and working memory deficit, all of which are schizophrenia-related behaviors.
Our results implicate that abnormalities in the neuron-glia interactions at the
paranodal junctions can result in reduced CV in the CNS, which then induces behavioral
abnormalities related to schizophrenia.
author:
- first_name: Hisataka
full_name: Tanaka, Hisataka
last_name: Tanaka
- first_name: Jianmei
full_name: Ma, Jianmei
last_name: Ma
- first_name: Kenji
full_name: Tanaka, Kenji F
last_name: Tanaka
- first_name: Keizo
full_name: Takao, Keizo
last_name: Takao
- first_name: Munekazu
full_name: Komada, Munekazu
last_name: Komada
- first_name: Koichi
full_name: Tanda, Koichi
last_name: Tanda
- first_name: Ayaka
full_name: Suzuki, Ayaka
last_name: Suzuki
- first_name: Tomoko
full_name: Ishibashi, Tomoko
last_name: Ishibashi
- first_name: Hiroko
full_name: Baba, Hiroko
last_name: Baba
- first_name: Tadashi
full_name: Isa, Tadashi
last_name: Isa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Katsuhiko
full_name: Ono, Katsuhiko
last_name: Ono
- first_name: Tsuyoshi
full_name: Miyakawa, Tsuyoshi
last_name: Miyakawa
- first_name: Kazuhiro
full_name: Ikenaka, Kazuhiro
last_name: Ikenaka
citation:
ama: Tanaka H, Ma J, Tanaka K, et al. Mice with altered myelin proteolipid protein
gene expression display cognitive deficits accompanied by abnormal neuron-glia
interactions and decreased conduction velocities. Journal of Neuroscience.
2009;29(26):8363-8371. doi:10.1523/JNEUROSCI.3216-08.2009
apa: Tanaka, H., Ma, J., Tanaka, K., Takao, K., Komada, M., Tanda, K., … Ikenaka,
K. (2009). Mice with altered myelin proteolipid protein gene expression display
cognitive deficits accompanied by abnormal neuron-glia interactions and decreased
conduction velocities. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.3216-08.2009
chicago: Tanaka, Hisataka, Jianmei Ma, Kenji Tanaka, Keizo Takao, Munekazu Komada,
Koichi Tanda, Ayaka Suzuki, et al. “Mice with Altered Myelin Proteolipid Protein
Gene Expression Display Cognitive Deficits Accompanied by Abnormal Neuron-Glia
Interactions and Decreased Conduction Velocities.” Journal of Neuroscience.
Society for Neuroscience, 2009. https://doi.org/10.1523/JNEUROSCI.3216-08.2009.
ieee: H. Tanaka et al., “Mice with altered myelin proteolipid protein gene
expression display cognitive deficits accompanied by abnormal neuron-glia interactions
and decreased conduction velocities,” Journal of Neuroscience, vol. 29,
no. 26. Society for Neuroscience, pp. 8363–8371, 2009.
ista: Tanaka H, Ma J, Tanaka K, Takao K, Komada M, Tanda K, Suzuki A, Ishibashi
T, Baba H, Isa T, Shigemoto R, Ono K, Miyakawa T, Ikenaka K. 2009. Mice with altered
myelin proteolipid protein gene expression display cognitive deficits accompanied
by abnormal neuron-glia interactions and decreased conduction velocities. Journal
of Neuroscience. 29(26), 8363–8371.
mla: Tanaka, Hisataka, et al. “Mice with Altered Myelin Proteolipid Protein Gene
Expression Display Cognitive Deficits Accompanied by Abnormal Neuron-Glia Interactions
and Decreased Conduction Velocities.” Journal of Neuroscience, vol. 29,
no. 26, Society for Neuroscience, 2009, pp. 8363–71, doi:10.1523/JNEUROSCI.3216-08.2009.
short: H. Tanaka, J. Ma, K. Tanaka, K. Takao, M. Komada, K. Tanda, A. Suzuki, T.
Ishibashi, H. Baba, T. Isa, R. Shigemoto, K. Ono, T. Miyakawa, K. Ikenaka, Journal
of Neuroscience 29 (2009) 8363–8371.
date_created: 2018-12-11T11:59:03Z
date_published: 2009-07-01T00:00:00Z
date_updated: 2021-01-12T06:59:02Z
day: '01'
doi: 10.1523/JNEUROSCI.3216-08.2009
extern: 1
intvolume: ' 29'
issue: '26'
month: '07'
page: 8363 - 8371
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4213'
quality_controlled: 0
status: public
title: Mice with altered myelin proteolipid protein gene expression display cognitive
deficits accompanied by abnormal neuron-glia interactions and decreased conduction
velocities
type: journal_article
volume: 29
year: '2009'
...
---
_id: '2686'
abstract:
- lang: eng
text: Channelrhodopsin-2 (ChR2), one of the archea-type rhodopsins from green algae,
is a potentially useful optogenetic tool for restoring vision in patients with
photoreceptor degeneration, such as retinitis pigmentosa. If the ChR2 gene is
transferred to retinal ganglion cells (RGCs), which send visual information to
the brain, the RGCs may be repurposed to act as photoreceptors. In this study,
by using a transgenic rat expressing ChR2 specifically in the RGCs under the regulation
of a Thy-1.2 promoter, we tested the possibility that direct photoactivation of
RGCs could restore effective vision. Although the contrast sensitivities of the
optomotor responses of transgenic rats were similar to those observed in the wild-type
rats, they were enhanced for visual stimuli of low-spatial frequency after the
degeneration of native photoreceptors. This result suggests that the visual signals
derived from the ChR2-expressing RGCs were reinterpreted by the brain to form
behavior-related vision.
author:
- first_name: Hiroshi
full_name: Tomita, Hiroshi
last_name: Tomita
- first_name: Eriko
full_name: Sugano, Eriko
last_name: Sugano
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Hitomi
full_name: Isago, Hitomi
last_name: Isago
- first_name: Yuka
full_name: Sugiyama, Yuka
last_name: Sugiyama
- first_name: Teru
full_name: Hiroi, Teru
last_name: Hiroi
- first_name: Toru
full_name: Ishizuka, Toru
last_name: Ishizuka
- first_name: Hajime
full_name: Mushiake, Hajime
last_name: Mushiake
- first_name: Megumi
full_name: Kato, Megumi
last_name: Kato
- first_name: Masumi
full_name: Hirabayashi, Masumi
last_name: Hirabayashi
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hiromu
full_name: Yawo, Hiromu
last_name: Yawo
- first_name: Makoto
full_name: Tamai, Makoto
last_name: Tamai
citation:
ama: Tomita H, Sugano E, Fukazawa Y, et al. Visual properties of transgenic rats
harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter. PLoS
One. 2009;4(11). doi:10.1371/journal.pone.0007679
apa: Tomita, H., Sugano, E., Fukazawa, Y., Isago, H., Sugiyama, Y., Hiroi, T., …
Tamai, M. (2009). Visual properties of transgenic rats harboring the channelrhodopsin-2
gene regulated by the thy-1.2 promoter. PLoS One. Public Library of Science.
https://doi.org/10.1371/journal.pone.0007679
chicago: Tomita, Hiroshi, Eriko Sugano, Yugo Fukazawa, Hitomi Isago, Yuka Sugiyama,
Teru Hiroi, Toru Ishizuka, et al. “Visual Properties of Transgenic Rats Harboring
the Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter.” PLoS One.
Public Library of Science, 2009. https://doi.org/10.1371/journal.pone.0007679.
ieee: H. Tomita et al., “Visual properties of transgenic rats harboring the
channelrhodopsin-2 gene regulated by the thy-1.2 promoter,” PLoS One, vol.
4, no. 11. Public Library of Science, 2009.
ista: Tomita H, Sugano E, Fukazawa Y, Isago H, Sugiyama Y, Hiroi T, Ishizuka T,
Mushiake H, Kato M, Hirabayashi M, Shigemoto R, Yawo H, Tamai M. 2009. Visual
properties of transgenic rats harboring the channelrhodopsin-2 gene regulated
by the thy-1.2 promoter. PLoS One. 4(11).
mla: Tomita, Hiroshi, et al. “Visual Properties of Transgenic Rats Harboring the
Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter.” PLoS One, vol.
4, no. 11, Public Library of Science, 2009, doi:10.1371/journal.pone.0007679.
short: H. Tomita, E. Sugano, Y. Fukazawa, H. Isago, Y. Sugiyama, T. Hiroi, T. Ishizuka,
H. Mushiake, M. Kato, M. Hirabayashi, R. Shigemoto, H. Yawo, M. Tamai, PLoS One
4 (2009).
date_created: 2018-12-11T11:59:04Z
date_published: 2009-11-05T00:00:00Z
date_updated: 2021-01-12T06:59:03Z
day: '05'
doi: 10.1371/journal.pone.0007679
extern: 1
intvolume: ' 4'
issue: '11'
month: '11'
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '4211'
quality_controlled: 0
status: public
title: Visual properties of transgenic rats harboring the channelrhodopsin-2 gene
regulated by the thy-1.2 promoter
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 4
year: '2009'
...
---
_id: '2703'
abstract:
- lang: eng
text: 'We consider N×N Hermitian random matrices with i.i.d. entries. The matrix
is normalized so that the average spacing between consecutive eigenvalues is of
order 1/N. We study the connection between eigenvalue statistics on microscopic
energy scales η≪1 and (de)localization properties of the eigenvectors. Under suitable
assumptions on the distribution of the single matrix elements, we first give an
upper bound on the density of states on short energy scales of order η∼log N/N.
We then prove that the density of states concentrates around the Wigner semicircle
law on energy scales η≫N−2/3. We show that most eigenvectors are fully delocalized
in the sense that their ℓp-norms are comparable with N1/p−1/2 for p≥2, and we
obtain the weaker bound N2/3(1/p−1/2) for all eigenvectors whose eigenvalues are
separated away from the spectral edges. We also prove that, with a probability
very close to one, no eigenvector can be localized. Finally, we give an optimal
bound on the second moment of the Green function. '
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Horng
full_name: Yau, Horng-Tzer
last_name: Yau
citation:
ama: Erdös L, Schlein B, Yau H. Semicircle law on short scales and delocalization
of eigenvectors for Wigner random matrices. Annals of Probability. 2009;37(3):815-852.
doi:10.1214/08-AOP421
apa: Erdös, L., Schlein, B., & Yau, H. (2009). Semicircle law on short scales
and delocalization of eigenvectors for Wigner random matrices. Annals of Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/08-AOP421
chicago: Erdös, László, Benjamin Schlein, and Horng Yau. “Semicircle Law on Short
Scales and Delocalization of Eigenvectors for Wigner Random Matrices.” Annals
of Probability. Institute of Mathematical Statistics, 2009. https://doi.org/10.1214/08-AOP421.
ieee: L. Erdös, B. Schlein, and H. Yau, “Semicircle law on short scales and delocalization
of eigenvectors for Wigner random matrices,” Annals of Probability, vol.
37, no. 3. Institute of Mathematical Statistics, pp. 815–852, 2009.
ista: Erdös L, Schlein B, Yau H. 2009. Semicircle law on short scales and delocalization
of eigenvectors for Wigner random matrices. Annals of Probability. 37(3), 815–852.
mla: Erdös, László, et al. “Semicircle Law on Short Scales and Delocalization of
Eigenvectors for Wigner Random Matrices.” Annals of Probability, vol. 37,
no. 3, Institute of Mathematical Statistics, 2009, pp. 815–52, doi:10.1214/08-AOP421.
short: L. Erdös, B. Schlein, H. Yau, Annals of Probability 37 (2009) 815–852.
date_created: 2018-12-11T11:59:09Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:09Z
day: '01'
doi: 10.1214/08-AOP421
extern: 1
intvolume: ' 37'
issue: '3'
main_file_link:
- open_access: '0'
url: http://xxx.lanl.gov/abs/0711.1730
month: '01'
page: 815 - 852
publication: Annals of Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '4193'
quality_controlled: 0
status: public
title: Semicircle law on short scales and delocalization of eigenvectors for Wigner
random matrices
type: journal_article
volume: 37
year: '2009'
...
---
_id: '2757'
abstract:
- lang: eng
text: We propose a new approach for the study of the time evolution of a factorized
N-particle bosonic wave function with respect to a mean-field dynamics with a
bounded interaction potential. The new technique, which is based on the control
of the growth of the correlations among the particles, leads to quantitative bounds
on the difference between the many-particle Schrödinger dynamics and the one-particle
nonlinear Hartree dynamics. In particular the one-particle density matrix associated
with the solution to the N-particle Schrödinger equation is shown to converge
to the projection onto the one-dimensional sub-space spanned by the solution to
the Hartree equation with a speed of convergence of order 1/N for all fixed times.
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
citation:
ama: 'Erdös L, Schlein B. Quantum dynamics with mean field interactions: A new approach.
Journal of Statistical Physics. 2009;134(5-6):859-870. doi:10.1007/s10955-008-9570-7'
apa: 'Erdös, L., & Schlein, B. (2009). Quantum dynamics with mean field interactions:
A new approach. Journal of Statistical Physics. Springer. https://doi.org/10.1007/s10955-008-9570-7'
chicago: 'Erdös, László, and Benjamin Schlein. “Quantum Dynamics with Mean Field
Interactions: A New Approach.” Journal of Statistical Physics. Springer,
2009. https://doi.org/10.1007/s10955-008-9570-7.'
ieee: 'L. Erdös and B. Schlein, “Quantum dynamics with mean field interactions:
A new approach,” Journal of Statistical Physics, vol. 134, no. 5–6. Springer,
pp. 859–870, 2009.'
ista: 'Erdös L, Schlein B. 2009. Quantum dynamics with mean field interactions:
A new approach. Journal of Statistical Physics. 134(5–6), 859–870.'
mla: 'Erdös, László, and Benjamin Schlein. “Quantum Dynamics with Mean Field Interactions:
A New Approach.” Journal of Statistical Physics, vol. 134, no. 5–6, Springer,
2009, pp. 859–70, doi:10.1007/s10955-008-9570-7.'
short: L. Erdös, B. Schlein, Journal of Statistical Physics 134 (2009) 859–870.
date_created: 2018-12-11T11:59:26Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:30Z
day: '01'
doi: 10.1007/s10955-008-9570-7
extern: 1
intvolume: ' 134'
issue: 5-6
month: '01'
page: 859 - 870
publication: Journal of Statistical Physics
publication_status: published
publisher: Springer
publist_id: '4135'
quality_controlled: 0
status: public
title: 'Quantum dynamics with mean field interactions: A new approach'
type: journal_article
volume: 134
year: '2009'
...
---
_id: '2758'
abstract:
- lang: eng
text: We consider N × N Hermitian random matrices with independent identical distributed
entries. The matrix is normalized so that the average spacing between consecutive
eigenvalues is of order 1/N. Under suitable assumptions on the distribution of
the single matrix element, we prove that, away from the spectral edges, the density
of eigenvalues concentrates around the Wigner semicircle law on energy scales
n ≫ N -1 (log N) 8 . Up to the logarithmic factor, this is the smallest energy
scale for which the semicircle law may be valid. We also prove that for all eigenvalues
away from the spectral edges, the -tempℓ∞-norm of the corresponding eigenvectors
is of order O(N -1/2), modulo logarithmic corrections. The upper bound O(N -1/2)
implies that every eigenvector is completely delocalized, i.e., the maximum size
of the components of the eigenvector is of the same order as their average size.
In the Appendix, we include a lemma by J. Bourgain which removes one of our assumptions
on the distribution of the matrix elements.
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Horng
full_name: Yau, Horng-Tzer
last_name: Yau
citation:
ama: Erdös L, Schlein B, Yau H. Local semicircle law and complete delocalization
for Wigner random matrices. Communications in Mathematical Physics. 2009;287(2):641-655.
doi:10.1007/s00220-008-0636-9
apa: Erdös, L., Schlein, B., & Yau, H. (2009). Local semicircle law and complete
delocalization for Wigner random matrices. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s00220-008-0636-9
chicago: Erdös, László, Benjamin Schlein, and Horng Yau. “Local Semicircle Law and
Complete Delocalization for Wigner Random Matrices.” Communications in Mathematical
Physics. Springer, 2009. https://doi.org/10.1007/s00220-008-0636-9.
ieee: L. Erdös, B. Schlein, and H. Yau, “Local semicircle law and complete delocalization
for Wigner random matrices,” Communications in Mathematical Physics, vol.
287, no. 2. Springer, pp. 641–655, 2009.
ista: Erdös L, Schlein B, Yau H. 2009. Local semicircle law and complete delocalization
for Wigner random matrices. Communications in Mathematical Physics. 287(2), 641–655.
mla: Erdös, László, et al. “Local Semicircle Law and Complete Delocalization for
Wigner Random Matrices.” Communications in Mathematical Physics, vol. 287,
no. 2, Springer, 2009, pp. 641–55, doi:10.1007/s00220-008-0636-9.
short: L. Erdös, B. Schlein, H. Yau, Communications in Mathematical Physics 287
(2009) 641–655.
date_created: 2018-12-11T11:59:27Z
date_published: 2009-04-01T00:00:00Z
date_updated: 2021-01-12T06:59:30Z
day: '01'
doi: 10.1007/s00220-008-0636-9
extern: 1
intvolume: ' 287'
issue: '2'
month: '04'
page: 641 - 655
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4134'
quality_controlled: 0
status: public
title: Local semicircle law and complete delocalization for Wigner random matrices
type: journal_article
volume: 287
year: '2009'
...
---
_id: '2759'
abstract:
- lang: eng
text: We consider the evolution of N bosons interacting with a repulsive short range
pair potential in three dimensions. The potential is scaled according to the Gross-Pitaevskii
scaling, i.e. it is given by N 2 V(N(x i - x j )). We monitor the behaviour of
the solution to the N-particle Schrödinger equation in a spatial window where
two particles are close to each other. We prove that within this window a short-scale
interparticle structure emerges dynamically. The local correlation between the
particles is given by the two-body zero energy scattering mode. This is the characteristic
structure that was expected to form within a very short initial time layer and
to persist for all later times, on the basis of the validity of the Gross-Pitaevskii
equation for the evolution of the Bose-Einstein condensate. The zero energy scattering
mode emerges after an initial time layer where all higher energy modes disperse
out of the spatial window. We can prove the persistence of this structure up to
sufficiently small times before three-particle correlations could develop.
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Alessandro
full_name: Michelangeli, Alessandro
last_name: Michelangeli
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
citation:
ama: Erdös L, Michelangeli A, Schlein B. Dynamical formation of correlations in
a Bose-Einstein condensate. Communications in Mathematical Physics. 2009;289(3):1171-1210.
doi:10.1007/s00220-009-0828-y
apa: Erdös, L., Michelangeli, A., & Schlein, B. (2009). Dynamical formation
of correlations in a Bose-Einstein condensate. Communications in Mathematical
Physics. Springer. https://doi.org/10.1007/s00220-009-0828-y
chicago: Erdös, László, Alessandro Michelangeli, and Benjamin Schlein. “Dynamical
Formation of Correlations in a Bose-Einstein Condensate.” Communications in
Mathematical Physics. Springer, 2009. https://doi.org/10.1007/s00220-009-0828-y.
ieee: L. Erdös, A. Michelangeli, and B. Schlein, “Dynamical formation of correlations
in a Bose-Einstein condensate,” Communications in Mathematical Physics,
vol. 289, no. 3. Springer, pp. 1171–1210, 2009.
ista: Erdös L, Michelangeli A, Schlein B. 2009. Dynamical formation of correlations
in a Bose-Einstein condensate. Communications in Mathematical Physics. 289(3),
1171–1210.
mla: Erdös, László, et al. “Dynamical Formation of Correlations in a Bose-Einstein
Condensate.” Communications in Mathematical Physics, vol. 289, no. 3, Springer,
2009, pp. 1171–210, doi:10.1007/s00220-009-0828-y.
short: L. Erdös, A. Michelangeli, B. Schlein, Communications in Mathematical Physics
289 (2009) 1171–1210.
date_created: 2018-12-11T11:59:27Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2021-01-12T06:59:30Z
day: '01'
doi: 10.1007/s00220-009-0828-y
extern: 1
intvolume: ' 289'
issue: '3'
month: '08'
page: 1171 - 1210
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4133'
quality_controlled: 0
status: public
title: Dynamical formation of correlations in a Bose-Einstein condensate
type: journal_article
volume: 289
year: '2009'
...
---
_id: '2760'
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Benjamin
full_name: Schlein, Benjamin
last_name: Schlein
- first_name: Horng
full_name: Yau, Horng-Tzer
last_name: Yau
citation:
ama: Erdös L, Schlein B, Yau H. Rigorous derivation of the gross-pitaevskii equation
with a large interaction potential. Journal of the American Mathematical Society.
2009;22(4):1099-1156. doi:10.1090/S0894-0347-09-00635-3
apa: Erdös, L., Schlein, B., & Yau, H. (2009). Rigorous derivation of the gross-pitaevskii
equation with a large interaction potential. Journal of the American Mathematical
Society. American Mathematical Society. https://doi.org/10.1090/S0894-0347-09-00635-3
chicago: Erdös, László, Benjamin Schlein, and Horng Yau. “Rigorous Derivation of
the Gross-Pitaevskii Equation with a Large Interaction Potential.” Journal
of the American Mathematical Society. American Mathematical Society, 2009.
https://doi.org/10.1090/S0894-0347-09-00635-3.
ieee: L. Erdös, B. Schlein, and H. Yau, “Rigorous derivation of the gross-pitaevskii
equation with a large interaction potential,” Journal of the American Mathematical
Society, vol. 22, no. 4. American Mathematical Society, pp. 1099–1156, 2009.
ista: Erdös L, Schlein B, Yau H. 2009. Rigorous derivation of the gross-pitaevskii
equation with a large interaction potential. Journal of the American Mathematical
Society. 22(4), 1099–1156.
mla: Erdös, László, et al. “Rigorous Derivation of the Gross-Pitaevskii Equation
with a Large Interaction Potential.” Journal of the American Mathematical Society,
vol. 22, no. 4, American Mathematical Society, 2009, pp. 1099–156, doi:10.1090/S0894-0347-09-00635-3.
short: L. Erdös, B. Schlein, H. Yau, Journal of the American Mathematical Society
22 (2009) 1099–1156.
date_created: 2018-12-11T11:59:27Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2021-01-12T06:59:31Z
day: '01'
doi: 10.1090/S0894-0347-09-00635-3
extern: 1
intvolume: ' 22'
issue: '4'
month: '10'
page: 1099 - 1156
publication: Journal of the American Mathematical Society
publication_status: published
publisher: American Mathematical Society
publist_id: '4132'
quality_controlled: 0
status: public
title: Rigorous derivation of the gross-pitaevskii equation with a large interaction
potential
type: journal_article
volume: 22
year: '2009'
...
---
_id: '2796'
abstract:
- lang: eng
text: As reported in a number of recent studies, turbulence in pipe flow is transient
for Re<2000 and the flow eventually always returns to the laminar state. Generally,
the lifetime of turbulence has been observed to increase rapidly with Reynolds
number but there is currently no accord on the exact scaling behaviour. In particular,
it is not clear whether a critical point exists where turbulence becomes sustained
or if it remains transient. We here aim to clarify if these conflicting results
may have been caused by the different experimental and numerical protocols used
to trigger turbulence in these studies.
author:
- first_name: Alberto
full_name: de Lózar, Alberto
last_name: De Lózar
- first_name: Björn
full_name: Björn Hof
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: De Lózar A, Hof B. An experimental study of the decay of turbulent puffs in
pipe flow. Philosophical Transactions of the Royal Society A Mathematical Physical
and Engineering Sciences. 2009;367(1888):589-599. doi:10.1098/rsta.2008.0199
apa: De Lózar, A., & Hof, B. (2009). An experimental study of the decay of turbulent
puffs in pipe flow. Philosophical Transactions of the Royal Society A Mathematical
Physical and Engineering Sciences. Royal Society of London. https://doi.org/10.1098/rsta.2008.0199
chicago: De Lózar, Alberto, and Björn Hof. “An Experimental Study of the Decay of
Turbulent Puffs in Pipe Flow.” Philosophical Transactions of the Royal Society
A Mathematical Physical and Engineering Sciences. Royal Society of London,
2009. https://doi.org/10.1098/rsta.2008.0199.
ieee: A. De Lózar and B. Hof, “An experimental study of the decay of turbulent puffs
in pipe flow,” Philosophical Transactions of the Royal Society A Mathematical
Physical and Engineering Sciences, vol. 367, no. 1888. Royal Society of London,
pp. 589–599, 2009.
ista: De Lózar A, Hof B. 2009. An experimental study of the decay of turbulent puffs
in pipe flow. Philosophical Transactions of the Royal Society A Mathematical Physical
and Engineering Sciences. 367(1888), 589–599.
mla: De Lózar, Alberto, and Björn Hof. “An Experimental Study of the Decay of Turbulent
Puffs in Pipe Flow.” Philosophical Transactions of the Royal Society A Mathematical
Physical and Engineering Sciences, vol. 367, no. 1888, Royal Society of London,
2009, pp. 589–99, doi:10.1098/rsta.2008.0199.
short: A. De Lózar, B. Hof, Philosophical Transactions of the Royal Society A Mathematical
Physical and Engineering Sciences 367 (2009) 589–599.
date_created: 2018-12-11T11:59:38Z
date_published: 2009-02-13T00:00:00Z
date_updated: 2021-01-12T06:59:46Z
day: '13'
doi: 10.1098/rsta.2008.0199
extern: 1
intvolume: ' 367'
issue: '1888'
month: '02'
page: 589 - 599
publication: Philosophical Transactions of the Royal Society A Mathematical Physical
and Engineering Sciences
publication_status: published
publisher: Royal Society of London
publist_id: '4093'
quality_controlled: 0
status: public
title: An experimental study of the decay of turbulent puffs in pipe flow
type: journal_article
volume: 367
year: '2009'
...
---
_id: '2797'
abstract:
- lang: eng
text: In pipe flow at low Reynolds number, decay of localized disturbances is observed.
As the Reynolds number is increased, the question emerges whether the life time
of these disturbances diverges at a finite Reynolds number or remains transient.
In the current investigation we determine their life time quantitatively from
pressure measurements, while in previous investigations the distance over which
a structure survives has been determined. The obtained results confirm that the
life time of localized disturbances does not diverge in the range of Reynolds
numbers covered in the current experiment.
alternative_title:
- Springer Proceedings in Physics
author:
- first_name: Dirk
full_name: Kuik, Dirk J
last_name: Kuik
- first_name: Christian
full_name: Poelma, Christian
last_name: Poelma
- first_name: Björn
full_name: Björn Hof
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Jerry
full_name: Westerweel, Jerry
last_name: Westerweel
citation:
ama: 'Kuik D, Poelma C, Hof B, Westerweel J. Quantitative measurement of the life
time of turbulence in pipe flow. In: Vol 132. Springer; 2009:145-148. doi:10.1007/978-3-642-03085-7_36'
apa: 'Kuik, D., Poelma, C., Hof, B., & Westerweel, J. (2009). Quantitative measurement
of the life time of turbulence in pipe flow (Vol. 132, pp. 145–148). Presented
at the EETC11: European Turbulence Conference, Springer. https://doi.org/10.1007/978-3-642-03085-7_36'
chicago: Kuik, Dirk, Christian Poelma, Björn Hof, and Jerry Westerweel. “Quantitative
Measurement of the Life Time of Turbulence in Pipe Flow,” 132:145–48. Springer,
2009. https://doi.org/10.1007/978-3-642-03085-7_36.
ieee: 'D. Kuik, C. Poelma, B. Hof, and J. Westerweel, “Quantitative measurement
of the life time of turbulence in pipe flow,” presented at the EETC11: European
Turbulence Conference, 2009, vol. 132, pp. 145–148.'
ista: 'Kuik D, Poelma C, Hof B, Westerweel J. 2009. Quantitative measurement of
the life time of turbulence in pipe flow. EETC11: European Turbulence Conference,
Springer Proceedings in Physics, vol. 132, 145–148.'
mla: Kuik, Dirk, et al. Quantitative Measurement of the Life Time of Turbulence
in Pipe Flow. Vol. 132, Springer, 2009, pp. 145–48, doi:10.1007/978-3-642-03085-7_36.
short: D. Kuik, C. Poelma, B. Hof, J. Westerweel, in:, Springer, 2009, pp. 145–148.
conference:
name: 'EETC11: European Turbulence Conference'
date_created: 2018-12-11T11:59:39Z
date_published: 2009-09-01T00:00:00Z
date_updated: 2021-01-12T06:59:46Z
day: '01'
doi: 10.1007/978-3-642-03085-7_36
extern: 1
intvolume: ' 132'
month: '09'
page: 145 - 148
publication_status: published
publisher: Springer
publist_id: '4092'
quality_controlled: 0
status: public
title: Quantitative measurement of the life time of turbulence in pipe flow
type: conference
volume: 132
year: '2009'
...
---
_id: '2868'
abstract:
- lang: eng
text: |
Plants exhibit an amazing developmental flexibility. Plant embryogenesis results in the establishment of a simple apical-basal axis represented by apical shoot and basal root meristems. Later, during postembryonic growth, shaping of the plant body continues by the formation and activation of numerous adjacent meristems that give rise to lateral shoot branches, leaves, flowers, or lateral roots. This developmental plasticity reflects an important feature of the plant's life strategy based on the rapid reaction to different environmental stimuli, such as temperature fluctuations, availability of nutrients, light or water and response resulting in modulation of developmental programs. Plant hormones are important endogenous factors for the integration of these environmental inputs and regulation of plant development. After a period of studies focused primarily on single hormonal pathways that enabled us to understand the hormone perception and signal transduction mechanisms, it became obvious that the developmental output mediated by a single hormonal pathway is largely modified through a whole network of interactions with other hormonal pathways. In this review, we will summarize recent knowledge on hormonal networks that regulate the development and growth of root with focus on the hormonal interactions that shape the root apical meristem.
author:
- first_name: Eva
full_name: Eva Benková
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jan
full_name: Hejátko, Jan
last_name: Hejátko
citation:
ama: Benková E, Hejátko J. Hormone interactions at the root apical meristem. Plant
Molecular Biology. 2009;69(4):383-396. doi:10.1007/s11103-008-9393-6
apa: Benková, E., & Hejátko, J. (2009). Hormone interactions at the root apical
meristem. Plant Molecular Biology. Springer. https://doi.org/10.1007/s11103-008-9393-6
chicago: Benková, Eva, and Jan Hejátko. “Hormone Interactions at the Root Apical
Meristem.” Plant Molecular Biology. Springer, 2009. https://doi.org/10.1007/s11103-008-9393-6.
ieee: E. Benková and J. Hejátko, “Hormone interactions at the root apical meristem,”
Plant Molecular Biology, vol. 69, no. 4. Springer, pp. 383–396, 2009.
ista: Benková E, Hejátko J. 2009. Hormone interactions at the root apical meristem.
Plant Molecular Biology. 69(4), 383–396.
mla: Benková, Eva, and Jan Hejátko. “Hormone Interactions at the Root Apical Meristem.”
Plant Molecular Biology, vol. 69, no. 4, Springer, 2009, pp. 383–96, doi:10.1007/s11103-008-9393-6.
short: E. Benková, J. Hejátko, Plant Molecular Biology 69 (2009) 383–396.
date_created: 2018-12-11T12:00:01Z
date_published: 2009-03-01T00:00:00Z
date_updated: 2021-01-12T07:00:22Z
day: '01'
doi: 10.1007/s11103-008-9393-6
extern: 1
intvolume: ' 69'
issue: '4'
month: '03'
page: 383 - 396
publication: Plant Molecular Biology
publication_status: published
publisher: Springer
publist_id: '3903'
quality_controlled: 0
status: public
title: Hormone interactions at the root apical meristem
type: journal_article
volume: 69
year: '2009'
...
---
_id: '2869'
abstract:
- lang: eng
text: Lateral root formation is a major determinant of root systems architecture.
The degree of root branching impacts the efficiency of water uptake, acquisition
of nutrients and anchorage by plants. Understanding the regulation of lateral
root development is therefore of vital agronomic importance. The molecular and
cellular basis of lateral root formation has been most extensively studied in
the plant model Arabidopsis thaliana (Arabidopsis). Significant progress has recently
been made in identifying many new Arabidopsis genes that regulate lateral root
initiation, patterning and emergence processes. We review how these studies have
revealed that the plant hormone auxin represents a common signal that integrates
these distinct yet interconnected developmental processes.
author:
- first_name: Benjamin
full_name: Péret, Benjamin
last_name: Péret
- first_name: Bert
full_name: De Rybel, Bert
last_name: De Rybel
- first_name: Ilda
full_name: Casimiro, Ilda
last_name: Casimiro
- first_name: Eva
full_name: Eva Benková
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Laurent
full_name: Laplaze, Laurent
last_name: Laplaze
- first_name: Tom
full_name: Beeckman, Tom
last_name: Beeckman
- first_name: Malcolm
full_name: Bennett, Malcolm J
last_name: Bennett
citation:
ama: 'Péret B, De Rybel B, Casimiro I, et al. Arabidopsis lateral root development:
an emerging story. Trends in Plant Science. 2009;14(7):399-408. doi:10.1016/j.tplants.2009.05.002'
apa: 'Péret, B., De Rybel, B., Casimiro, I., Benková, E., Swarup, R., Laplaze, L.,
… Bennett, M. (2009). Arabidopsis lateral root development: an emerging story.
Trends in Plant Science. Cell Press. https://doi.org/10.1016/j.tplants.2009.05.002'
chicago: 'Péret, Benjamin, Bert De Rybel, Ilda Casimiro, Eva Benková, Ranjan Swarup,
Laurent Laplaze, Tom Beeckman, and Malcolm Bennett. “Arabidopsis Lateral Root
Development: An Emerging Story.” Trends in Plant Science. Cell Press, 2009.
https://doi.org/10.1016/j.tplants.2009.05.002.'
ieee: 'B. Péret et al., “Arabidopsis lateral root development: an emerging
story,” Trends in Plant Science, vol. 14, no. 7. Cell Press, pp. 399–408,
2009.'
ista: 'Péret B, De Rybel B, Casimiro I, Benková E, Swarup R, Laplaze L, Beeckman
T, Bennett M. 2009. Arabidopsis lateral root development: an emerging story. Trends
in Plant Science. 14(7), 399–408.'
mla: 'Péret, Benjamin, et al. “Arabidopsis Lateral Root Development: An Emerging
Story.” Trends in Plant Science, vol. 14, no. 7, Cell Press, 2009, pp.
399–408, doi:10.1016/j.tplants.2009.05.002.'
short: B. Péret, B. De Rybel, I. Casimiro, E. Benková, R. Swarup, L. Laplaze, T.
Beeckman, M. Bennett, Trends in Plant Science 14 (2009) 399–408.
date_created: 2018-12-11T12:00:02Z
date_published: 2009-07-01T00:00:00Z
date_updated: 2021-01-12T07:00:22Z
day: '01'
doi: 10.1016/j.tplants.2009.05.002
extern: 1
intvolume: ' 14'
issue: '7'
month: '07'
page: 399 - 408
publication: Trends in Plant Science
publication_status: published
publisher: Cell Press
publist_id: '3899'
quality_controlled: 0
status: public
title: 'Arabidopsis lateral root development: an emerging story'
type: journal_article
volume: 14
year: '2009'
...