---
_id: '8074'
abstract:
- lang: eng
text: Cortical neurons receive balanced excitatory and inhibitory synaptic currents.
Such a balance could be established and maintained in an experience-dependent
manner by synaptic plasticity at inhibitory synapses. We show that this mechanism
provides an explanation for the sparse firing patterns observed in response to
natural stimuli and fits well with a recently observed interaction of excitatory
and inhibitory receptive field plasticity. The introduction of inhibitory plasticity
in suitable recurrent networks provides a homeostatic mechanism that leads to
asynchronous irregular network states. Further, it can accommodate synaptic memories
with activity patterns that become indiscernible from the background state but
can be reactivated by external stimuli. Our results suggest an essential role
of inhibitory plasticity in the formation and maintenance of functional cortical
circuitry.
article_processing_charge: No
article_type: original
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: H.
full_name: Sprekeler, H.
last_name: Sprekeler
- first_name: F.
full_name: Zenke, F.
last_name: Zenke
- first_name: C.
full_name: Clopath, C.
last_name: Clopath
- first_name: W.
full_name: Gerstner, W.
last_name: Gerstner
citation:
ama: Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. Inhibitory plasticity
balances excitation and inhibition in sensory pathways and memory networks. Science.
2011;334(6062):1569-1573. doi:10.1126/science.1211095
apa: Vogels, T. P., Sprekeler, H., Zenke, F., Clopath, C., & Gerstner, W. (2011).
Inhibitory plasticity balances excitation and inhibition in sensory pathways and
memory networks. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.1211095
chicago: Vogels, Tim P, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner. “Inhibitory
Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.”
Science. American Association for the Advancement of Science, 2011. https://doi.org/10.1126/science.1211095.
ieee: T. P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner, “Inhibitory
plasticity balances excitation and inhibition in sensory pathways and memory networks,”
Science, vol. 334, no. 6062. American Association for the Advancement of
Science, pp. 1569–1573, 2011.
ista: Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. 2011. Inhibitory plasticity
balances excitation and inhibition in sensory pathways and memory networks. Science.
334(6062), 1569–1573.
mla: Vogels, Tim P., et al. “Inhibitory Plasticity Balances Excitation and Inhibition
in Sensory Pathways and Memory Networks.” Science, vol. 334, no. 6062,
American Association for the Advancement of Science, 2011, pp. 1569–73, doi:10.1126/science.1211095.
short: T.P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, W. Gerstner, Science 334
(2011) 1569–1573.
date_created: 2020-06-30T13:26:17Z
date_published: 2011-12-16T00:00:00Z
date_updated: 2021-06-02T14:57:22Z
day: '16'
doi: 10.1126/science.1211095
extern: '1'
external_id:
pmid:
- '22075724'
intvolume: ' 334'
issue: '6062'
language:
- iso: eng
month: '12'
oa_version: None
page: 1569-1573
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1126/science.336.6083.802-c
scopus_import: '1'
status: public
title: Inhibitory plasticity balances excitation and inhibition in sensory pathways
and memory networks
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 334
year: '2011'
...
---
_id: '1723'
abstract:
- lang: eng
text: The emergence of differences in the arrangement of cells is the first step
towards the establishment of many organs. Understanding this process is limited
by the lack of systematic characterization of epithelial organisation. Here we
apply network theory at the scale of individual cells to uncover patterns in cell-to-cell
contacts that govern epithelial organisation. We provide an objective characterisation
of epithelia using network representation, where cells are nodes and cell contacts
are links. The features of individual cells, together with attributes of the cellular
network, produce a defining signature that distinguishes epithelia from different
organs, species, developmental stages and genetic conditions. The approach permits
characterization, quantification and classification of normal and perturbed epithelia,
and establishes a framework for understanding molecular mechanisms that underpin
the architecture of complex tissues.
acknowledgement: We acknowledge the MRC for funding, M.M.B. acknowledges Darwin College,
EMBO YIP and Schlumberger Ltd for support. L.M.E. is funded by the Marie Curie and
the EMBO fellowships. L.d.F.C. is grateful to FAPESP (05/00587-5) and CNPq (301303/06-1)
for financial support. Part of this work was performed during a Visiting Scholarship
to L.d.F.C. from St Catharine's College, University of Cambridge. J.B. is supported
by the MRC (UK) and A.K. by a FEBS fellowship
author:
- first_name: Luis
full_name: Escudero, Luis M
last_name: Escudero
- first_name: Luciano
full_name: Costa, Luciano
last_name: Costa
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Matthew
full_name: Freeman, Matthew
last_name: Freeman
- first_name: Madan
full_name: Babu, Madan M
last_name: Babu
citation:
ama: Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. Epithelial organisation
revealed by a network of cellular contacts. Nature Communications. 2011;2(1).
doi:10.1038/ncomms1536
apa: Escudero, L., Costa, L., Kicheva, A., Briscoe, J., Freeman, M., & Babu,
M. (2011). Epithelial organisation revealed by a network of cellular contacts.
Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms1536
chicago: Escudero, Luis, Luciano Costa, Anna Kicheva, James Briscoe, Matthew Freeman,
and Madan Babu. “Epithelial Organisation Revealed by a Network of Cellular Contacts.”
Nature Communications. Nature Publishing Group, 2011. https://doi.org/10.1038/ncomms1536.
ieee: L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, and M. Babu, “Epithelial
organisation revealed by a network of cellular contacts,” Nature Communications,
vol. 2, no. 1. Nature Publishing Group, 2011.
ista: Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. 2011. Epithelial
organisation revealed by a network of cellular contacts. Nature Communications.
2(1).
mla: Escudero, Luis, et al. “Epithelial Organisation Revealed by a Network of Cellular
Contacts.” Nature Communications, vol. 2, no. 1, Nature Publishing Group,
2011, doi:10.1038/ncomms1536.
short: L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, M. Babu, Nature
Communications 2 (2011).
date_created: 2018-12-11T11:53:40Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T06:52:46Z
day: '01'
doi: 10.1038/ncomms1536
extern: 1
intvolume: ' 2'
issue: '1'
month: '01'
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5405'
quality_controlled: 0
status: public
title: Epithelial organisation revealed by a network of cellular contacts
type: journal_article
volume: 2
year: '2011'
...
---
_id: '1724'
abstract:
- lang: eng
text: Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form
graded concentration profiles that control patterning and growth of developing
organs. In the imaginal discs, proliferative growth is homogeneous in space, posing
the conundrum of how morphogen concentration gradients could control position-independent
growth. To understand the mechanism of proliferation control by the Dpp gradient,
we quantified Dpp concentration and signaling levels during wing disc growth.
Both Dpp concentration and signaling gradients scale with tissue size during development.
On average, cells divide when Dpp signaling levels have increased by 50%. Our
observations are consistent with a growth control mechanism based on temporal
changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism
generates position-independent growth rates.
acknowledgement: P.M., T.B., and F.J. were supported by the Max-Planck-Gesellschaft.
O.W., A.K., C.S., and M.G.-G. were supported by Geneva University and by European
Research Council advanced investigator grant (SARA), SystemsX (LipidX), Swiss National
Science Foundation (SNF), National Centre of Competence in Research (NCCR) chemical
biology and Frontiers in Genetics and R'equip grants
author:
- first_name: Ortrud
full_name: Wartlick, Ortrud
last_name: Wartlick
- first_name: Peer
full_name: Mumcu, Peer
last_name: Mumcu
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Thomas
full_name: Bittig, Thomas
last_name: Bittig
- first_name: Carole
full_name: Seum, Carole
last_name: Seum
- first_name: Frank
full_name: Jülicher, Frank
last_name: Jülicher
- first_name: Marcos
full_name: González-Gaitán, Marcos A
last_name: González Gaitán
citation:
ama: Wartlick O, Mumcu P, Kicheva A, et al. Dynamics of Dpp signaling and proliferation
control. Science. 2011;331(6021):1154-1159. doi:10.1126/science.1200037
apa: Wartlick, O., Mumcu, P., Kicheva, A., Bittig, T., Seum, C., Jülicher, F., &
González Gaitán, M. (2011). Dynamics of Dpp signaling and proliferation control.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1200037
chicago: Wartlick, Ortrud, Peer Mumcu, Anna Kicheva, Thomas Bittig, Carole Seum,
Frank Jülicher, and Marcos González Gaitán. “Dynamics of Dpp Signaling and Proliferation
Control.” Science. American Association for the Advancement of Science,
2011. https://doi.org/10.1126/science.1200037.
ieee: O. Wartlick et al., “Dynamics of Dpp signaling and proliferation control,”
Science, vol. 331, no. 6021. American Association for the Advancement of
Science, pp. 1154–1159, 2011.
ista: Wartlick O, Mumcu P, Kicheva A, Bittig T, Seum C, Jülicher F, González Gaitán
M. 2011. Dynamics of Dpp signaling and proliferation control. Science. 331(6021),
1154–1159.
mla: Wartlick, Ortrud, et al. “Dynamics of Dpp Signaling and Proliferation Control.”
Science, vol. 331, no. 6021, American Association for the Advancement of
Science, 2011, pp. 1154–59, doi:10.1126/science.1200037.
short: O. Wartlick, P. Mumcu, A. Kicheva, T. Bittig, C. Seum, F. Jülicher, M. González
Gaitán, Science 331 (2011) 1154–1159.
date_created: 2018-12-11T11:53:40Z
date_published: 2011-03-04T00:00:00Z
date_updated: 2021-01-12T06:52:46Z
day: '04'
doi: 10.1126/science.1200037
extern: 1
intvolume: ' 331'
issue: '6021'
month: '03'
page: 1154 - 1159
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5406'
quality_controlled: 0
status: public
title: Dynamics of Dpp signaling and proliferation control
type: journal_article
volume: 331
year: '2011'
...
---
_id: '1754'
abstract:
- lang: eng
text: 'We report on a technique enabling electrical control of the contact silicidation
process in silicon nanowire devices. Undoped silicon nanowires were contacted
by pairs of nickel electrodes and each contact was selectively silicided by means
of the Joule effect. By a realtime monitoring of the nanowire electrical resistance
during the contact silicidation process we were able to fabricate nickel-silicide/silicon/nickel-
silicide devices with controlled silicon channel length down to 8 nm. '
acknowledgement: This work was supported by the Agence Nationale de la Recherche (ANR)
through the ACCESS and COHESION projects and by the European Commission through
the Chemtronics program MEST-CT-2005-020513
arxiv: 1
author:
- first_name: Massimo
full_name: Mongillo, Massimo
last_name: Mongillo
- first_name: Panayotis
full_name: Spathis, Panayotis
last_name: Spathis
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Pascal
full_name: Gentile, Pascal
last_name: Gentile
- first_name: Marc
full_name: Sanquer, Marc
last_name: Sanquer
- first_name: Silvano
full_name: De Franceschi, Silvano
last_name: De Franceschi
citation:
ama: Mongillo M, Spathis P, Katsaros G, Gentile P, Sanquer M, De Franceschi S. Joule-assisted
silicidation for short-channel silicon nanowire devices. ACS Nano. 2011;5(9):7117-7123.
doi:10.1021/nn202524j
apa: Mongillo, M., Spathis, P., Katsaros, G., Gentile, P., Sanquer, M., & De
Franceschi, S. (2011). Joule-assisted silicidation for short-channel silicon nanowire
devices. ACS Nano. American Chemical Society. https://doi.org/10.1021/nn202524j
chicago: Mongillo, Massimo, Panayotis Spathis, Georgios Katsaros, Pascal Gentile,
Marc Sanquer, and Silvano De Franceschi. “Joule-Assisted Silicidation for Short-Channel
Silicon Nanowire Devices.” ACS Nano. American Chemical Society, 2011. https://doi.org/10.1021/nn202524j.
ieee: M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, M. Sanquer, and S. De Franceschi,
“Joule-assisted silicidation for short-channel silicon nanowire devices,” ACS
Nano, vol. 5, no. 9. American Chemical Society, pp. 7117–7123, 2011.
ista: Mongillo M, Spathis P, Katsaros G, Gentile P, Sanquer M, De Franceschi S.
2011. Joule-assisted silicidation for short-channel silicon nanowire devices.
ACS Nano. 5(9), 7117–7123.
mla: Mongillo, Massimo, et al. “Joule-Assisted Silicidation for Short-Channel Silicon
Nanowire Devices.” ACS Nano, vol. 5, no. 9, American Chemical Society,
2011, pp. 7117–23, doi:10.1021/nn202524j.
short: M. Mongillo, P. Spathis, G. Katsaros, P. Gentile, M. Sanquer, S. De Franceschi,
ACS Nano 5 (2011) 7117–7123.
date_created: 2018-12-11T11:53:50Z
date_published: 2011-09-27T00:00:00Z
date_updated: 2021-01-12T06:52:59Z
day: '27'
doi: 10.1021/nn202524j
extern: '1'
external_id:
arxiv:
- '1110.5668'
intvolume: ' 5'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1110.5668
month: '09'
oa: 1
oa_version: Preprint
page: 7117 - 7123
publication: ACS Nano
publication_status: published
publisher: American Chemical Society
publist_id: '5370'
quality_controlled: '1'
status: public
title: Joule-assisted silicidation for short-channel silicon nanowire devices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2011'
...
---
_id: '1755'
abstract:
- lang: eng
text: Spin-selective tunneling of holes in SiGe nanocrystals contacted by normal-metal
leads is reported. The spin selectivity arises from an interplay of the orbital
effect of the magnetic field with the strong spin-orbit interaction present in
the valence band of the semiconductor. We demonstrate both experimentally and
theoretically that spin-selective tunneling in semiconductor nanostructures can
be achieved without the use of ferromagnetic contacts. The reported effect, which
relies on mixing the light and heavy holes, should be observable in a broad class
of quantum-dot systems formed in semiconductors with a degenerate valence band.
acknowledgement: The work was supported by the Agence Nationale de la Recherche (through
the ACCESS and COHESION projects), U.S. DOE Contract No. DE-FG02-08ER46482 (Yale),
and the Nanosciences Foundation at Grenoble, France. G. K. acknowledges support
from the Deutsche Forschungsgemeinschaft
author:
- first_name: Georgios
full_name: Georgios Katsaros
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
- first_name: Vitaly
full_name: Golovach, Vitaly N
last_name: Golovach
- first_name: Panayotis
full_name: Spathis, Panayotis N
last_name: Spathis
- first_name: Natalia
full_name: Ares, Natalia
last_name: Ares
- first_name: Mathieu
full_name: Stoffel, Mathieu
last_name: Stoffel
- first_name: Frank
full_name: Fournel, Frank
last_name: Fournel
- first_name: Oliver
full_name: Schmidt, Oliver G
last_name: Schmidt
- first_name: Leonid
full_name: Glazman, Leonid I
last_name: Glazman
- first_name: Silvano
full_name: De Franceschi, Silvano
last_name: De Franceschi
citation:
ama: Katsaros G, Golovach V, Spathis P, et al. Observation of spin-selective tunneling
in sige nanocrystals. Physical Review Letters. 2011;107(24). doi:10.1103/PhysRevLett.107.246601
apa: Katsaros, G., Golovach, V., Spathis, P., Ares, N., Stoffel, M., Fournel, F.,
… De Franceschi, S. (2011). Observation of spin-selective tunneling in sige nanocrystals.
Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.107.246601
chicago: Katsaros, Georgios, Vitaly Golovach, Panayotis Spathis, Natalia Ares, Mathieu
Stoffel, Frank Fournel, Oliver Schmidt, Leonid Glazman, and Silvano De Franceschi.
“Observation of Spin-Selective Tunneling in Sige Nanocrystals.” Physical Review
Letters. American Physical Society, 2011. https://doi.org/10.1103/PhysRevLett.107.246601.
ieee: G. Katsaros et al., “Observation of spin-selective tunneling in sige
nanocrystals,” Physical Review Letters, vol. 107, no. 24. American Physical
Society, 2011.
ista: Katsaros G, Golovach V, Spathis P, Ares N, Stoffel M, Fournel F, Schmidt O,
Glazman L, De Franceschi S. 2011. Observation of spin-selective tunneling in sige
nanocrystals. Physical Review Letters. 107(24).
mla: Katsaros, Georgios, et al. “Observation of Spin-Selective Tunneling in Sige
Nanocrystals.” Physical Review Letters, vol. 107, no. 24, American Physical
Society, 2011, doi:10.1103/PhysRevLett.107.246601.
short: G. Katsaros, V. Golovach, P. Spathis, N. Ares, M. Stoffel, F. Fournel, O.
Schmidt, L. Glazman, S. De Franceschi, Physical Review Letters 107 (2011).
date_created: 2018-12-11T11:53:50Z
date_published: 2011-12-07T00:00:00Z
date_updated: 2021-01-12T06:53:00Z
day: '07'
doi: 10.1103/PhysRevLett.107.246601
extern: 1
intvolume: ' 107'
issue: '24'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1107.3919
month: '12'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5369'
quality_controlled: 0
status: public
title: Observation of spin-selective tunneling in sige nanocrystals
type: journal_article
volume: 107
year: '2011'
...
---
_id: '1775'
abstract:
- lang: eng
text: At optical frequencies the radiation produced by a source, such as a laser,
a black body or a single-photon emitter, is frequently characterized by analysing
the temporal correlations of emitted photons using single-photon counters. At
microwave frequencies, however, there are no efficient single-photon counters
yet. Instead, well-developed linear amplifiers allow for efficient measurement
of the amplitude of an electromagnetic field. Here, we demonstrate first- and
second-order correlation function measurements of a pulsed microwave-frequency
single-photon source integrated on the same chip with a 50/50 beam splitter followed
by linear amplifiers and quadrature amplitude detectors. We clearly observe single-photon
coherence in first-order and photon antibunching in second-order correlation function
measurements of the propagating fields.
acknowledgement: This work was supported by the European Research Council (ERC) through
a Starting Grant and by ETHZ. M.P.d.S. was supported by a NSERC postdoctoral fellowship.
A.B. was supported by NSERC, CIFAR and the Alfred P. Sloan Foundation
author:
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: R
full_name: Bianchetti, R
last_name: Bianchetti
- first_name: Peter
full_name: Leek, Peter J
last_name: Leek
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: Marcus
full_name: Da Silva, Marcus P
last_name: Da Silva
- first_name: Alexandre
full_name: Blais, Alexandre
last_name: Blais
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Bozyigit D, Lang C, Steffen L, et al. Antibunching of microwave-frequency photons
observed in correlation measurements using linear detectors. Nature Physics.
2011;7(2):154-158. doi:10.1038/nphys1845
apa: Bozyigit, D., Lang, C., Steffen, L., Fink, J. M., Eichler, C., Baur, M., …
Wallraff, A. (2011). Antibunching of microwave-frequency photons observed in correlation
measurements using linear detectors. Nature Physics. Nature Publishing
Group. https://doi.org/10.1038/nphys1845
chicago: Bozyigit, Deniz, C Lang, L. Steffen, Johannes M Fink, Christopher Eichler,
Matthias Baur, R Bianchetti, et al. “Antibunching of Microwave-Frequency Photons
Observed in Correlation Measurements Using Linear Detectors.” Nature Physics.
Nature Publishing Group, 2011. https://doi.org/10.1038/nphys1845.
ieee: D. Bozyigit et al., “Antibunching of microwave-frequency photons observed
in correlation measurements using linear detectors,” Nature Physics, vol.
7, no. 2. Nature Publishing Group, pp. 154–158, 2011.
ista: Bozyigit D, Lang C, Steffen L, Fink JM, Eichler C, Baur M, Bianchetti R, Leek
P, Filipp S, Da Silva M, Blais A, Wallraff A. 2011. Antibunching of microwave-frequency
photons observed in correlation measurements using linear detectors. Nature Physics.
7(2), 154–158.
mla: Bozyigit, Deniz, et al. “Antibunching of Microwave-Frequency Photons Observed
in Correlation Measurements Using Linear Detectors.” Nature Physics, vol.
7, no. 2, Nature Publishing Group, 2011, pp. 154–58, doi:10.1038/nphys1845.
short: D. Bozyigit, C. Lang, L. Steffen, J.M. Fink, C. Eichler, M. Baur, R. Bianchetti,
P. Leek, S. Filipp, M. Da Silva, A. Blais, A. Wallraff, Nature Physics 7 (2011)
154–158.
date_created: 2018-12-11T11:53:57Z
date_published: 2011-02-01T00:00:00Z
date_updated: 2021-01-12T06:53:07Z
day: '01'
doi: 10.1038/nphys1845
extern: 1
intvolume: ' 7'
issue: '2'
month: '02'
page: 154 - 158
publication: Nature Physics
publication_status: published
publisher: Nature Publishing Group
publist_id: '5340'
quality_controlled: 0
status: public
title: Antibunching of microwave-frequency photons observed in correlation measurements
using linear detectors
type: journal_article
volume: 7
year: '2011'
...
---
_id: '1776'
abstract:
- lang: eng
text: Superconducting circuits have been successfully established as systems to
prepare and investigate microwave light fields at the quantum level. In contrast
to optical experiments where light is detected using photon counters, microwaves
are usually measured with well developed linear amplifiers. This makes measurements
of correlation functions - one of the important tools in optics - harder to achieve
because they traditionally rely on photon counters and beam splitters. Here, we
demonstrate a system where we can prepare on demand single microwave photons in
a cavity and detect them at the two outputs of the cavity using linear amplifiers.
Together with efficient data processing, this allows us to measure different observables
of the cavity photons, including the first-order correlation function. Using these
techniques we demonstrate cooling of a thermal background field in the cavity.
acknowledgement: Australian National University,Aust. Res. Counc. Cent. Excellence
Quantum-Atom Opt.,Griffith University,Ian Potter Foundation,International Union
of Pure and Applied Physics
alternative_title:
- 'Journal of Physics: Conference Series'
author:
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: R
full_name: Bianchetti, R
last_name: Bianchetti
- first_name: Peter
full_name: Leek, Peter J
last_name: Leek
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
- first_name: Marcus
full_name: Da Silva, Marcus P
last_name: Da Silva
- first_name: Alexandre
full_name: Blais, Alexandre
last_name: Blais
citation:
ama: 'Bozyigit D, Lang C, Steffen L, et al. Correlation measurements of individual
microwave photons emitted from a symmetric cavity. In: Vol 264. IOP Publishing
Ltd.; 2011. doi:10.1088/1742-6596/264/1/012024'
apa: Bozyigit, D., Lang, C., Steffen, L., Fink, J. M., Eichler, C., Baur, M., …
Blais, A. (2011). Correlation measurements of individual microwave photons emitted
from a symmetric cavity (Vol. 264). Presented at the International Conference
on Atomic Physics, IOP Publishing Ltd. https://doi.org/10.1088/1742-6596/264/1/012024
chicago: Bozyigit, Deniz, C Lang, L. Steffen, Johannes M Fink, Christopher Eichler,
Matthias Baur, R Bianchetti, et al. “Correlation Measurements of Individual Microwave
Photons Emitted from a Symmetric Cavity,” Vol. 264. IOP Publishing Ltd., 2011.
https://doi.org/10.1088/1742-6596/264/1/012024.
ieee: D. Bozyigit et al., “Correlation measurements of individual microwave
photons emitted from a symmetric cavity,” presented at the International Conference
on Atomic Physics, 2011, vol. 264, no. 1.
ista: 'Bozyigit D, Lang C, Steffen L, Fink JM, Eichler C, Baur M, Bianchetti R,
Leek P, Filipp S, Wallraff A, Da Silva M, Blais A. 2011. Correlation measurements
of individual microwave photons emitted from a symmetric cavity. International
Conference on Atomic Physics, Journal of Physics: Conference Series, vol. 264.'
mla: Bozyigit, Deniz, et al. Correlation Measurements of Individual Microwave
Photons Emitted from a Symmetric Cavity. Vol. 264, no. 1, IOP Publishing Ltd.,
2011, doi:10.1088/1742-6596/264/1/012024.
short: D. Bozyigit, C. Lang, L. Steffen, J.M. Fink, C. Eichler, M. Baur, R. Bianchetti,
P. Leek, S. Filipp, A. Wallraff, M. Da Silva, A. Blais, in:, IOP Publishing Ltd.,
2011.
conference:
name: International Conference on Atomic Physics
date_created: 2018-12-11T11:53:57Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2019-04-26T07:22:05Z
day: '01'
doi: 10.1088/1742-6596/264/1/012024
extern: 1
intvolume: ' 264'
issue: '1'
month: '01'
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '5339'
quality_controlled: 0
status: public
title: Correlation measurements of individual microwave photons emitted from a symmetric
cavity
type: conference
volume: 264
year: '2011'
...
---
_id: '1777'
abstract:
- lang: eng
text: A wide range of experiments studying microwave photons localized in superconducting
cavities have made important contributions to our understanding of the quantum
properties of radiation. Propagating microwave photons, however, have so far been
studied much less intensely. Here we present measurements in which we reconstruct
the quantum state of itinerant single photon Fock states and their superposition
with the vacuum by analyzing moments of the measured amplitude distribution up
to fourth order. Using linear amplifiers and quadrature amplitude detectors, we
have developed efficient methods to separate the detected single photon signal
from the noise added by the amplifier. From our measurement data we have also
reconstructed the corresponding Wigner function.
acknowledgement: This work was supported by the European Research Council (ERC) through
a Starting Grant and by ETHZ
article_processing_charge: No
author:
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: L.
full_name: Steffen, L.
last_name: Steffen
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Eichler C, Bozyigit D, Lang C, Steffen L, Fink JM, Wallraff A. Experimental
state tomography of itinerant single microwave photons. Physical Review Letters.
2011;106(22). doi:10.1103/PhysRevLett.106.220503
apa: Eichler, C., Bozyigit, D., Lang, C., Steffen, L., Fink, J. M., & Wallraff,
A. (2011). Experimental state tomography of itinerant single microwave photons.
Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.106.220503
chicago: Eichler, Christopher, Deniz Bozyigit, C Lang, L. Steffen, Johannes M Fink,
and Andreas Wallraff. “Experimental State Tomography of Itinerant Single Microwave
Photons.” Physical Review Letters. American Physical Society, 2011. https://doi.org/10.1103/PhysRevLett.106.220503.
ieee: C. Eichler, D. Bozyigit, C. Lang, L. Steffen, J. M. Fink, and A. Wallraff,
“Experimental state tomography of itinerant single microwave photons,” Physical
Review Letters, vol. 106, no. 22. American Physical Society, 2011.
ista: Eichler C, Bozyigit D, Lang C, Steffen L, Fink JM, Wallraff A. 2011. Experimental
state tomography of itinerant single microwave photons. Physical Review Letters.
106(22).
mla: Eichler, Christopher, et al. “Experimental State Tomography of Itinerant Single
Microwave Photons.” Physical Review Letters, vol. 106, no. 22, American
Physical Society, 2011, doi:10.1103/PhysRevLett.106.220503.
short: C. Eichler, D. Bozyigit, C. Lang, L. Steffen, J.M. Fink, A. Wallraff, Physical
Review Letters 106 (2011).
date_created: 2018-12-11T11:53:57Z
date_published: 2011-06-01T00:00:00Z
date_updated: 2021-11-16T07:57:13Z
day: '01'
doi: 10.1103/PhysRevLett.106.220503
extern: '1'
intvolume: ' 106'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1011.6668
month: '06'
oa: 1
oa_version: None
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5338'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1103/PhysRevLett.106.249901
status: public
title: Experimental state tomography of itinerant single microwave photons
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 106
year: '2011'
...
---
_id: '1778'
abstract:
- lang: eng
text: Creating a train of single photons and monitoring its propagation and interaction
is challenging in most physical systems, as photons generally interact very weakly
with other systems. However, when confining microwave frequency photons in a transmission
line resonator, effective photon-photon interactions can be mediated by qubits
embedded in the resonator. Here, we observe the phenomenon of photon blockade
through second-order correlation function measurements. The experiments clearly
demonstrate antibunching in a continuously pumped source of single microwave photons
measured by using microwave beam splitters, linear amplifiers, and quadrature
amplitude detectors. We also investigate resonance fluorescence and Rayleigh scattering
in Mollow-triplet-like spectra.
acknowledgement: This work was supported by the European Research Council (ERC) through
a Starting Grant and by ETHZ. M. P. d. S. was supported by NSERC. A. B. was supported
by NSERC, CIFAR, and the Alfred P. Sloan Foundation
author:
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Abdufarrukh
full_name: Abdumalikov, Abdufarrukh A
last_name: Abdumalikov
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: Marcus
full_name: Da Silva, Marcus P
last_name: Da Silva
- first_name: Alexandre
full_name: Blais, Alexandre
last_name: Blais
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Lang C, Bozyigit D, Eichler C, et al. Observation of resonant photon blockade
at microwave frequencies using correlation function measurements. Physical
Review Letters. 2011;106(24). doi:10.1103/PhysRevLett.106.243601
apa: Lang, C., Bozyigit, D., Eichler, C., Steffen, L., Fink, J. M., Abdumalikov,
A., … Wallraff, A. (2011). Observation of resonant photon blockade at microwave
frequencies using correlation function measurements. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/PhysRevLett.106.243601
chicago: Lang, C, Deniz Bozyigit, Christopher Eichler, L. Steffen, Johannes M Fink,
Abdufarrukh Abdumalikov, Matthias Baur, et al. “Observation of Resonant Photon
Blockade at Microwave Frequencies Using Correlation Function Measurements.” Physical
Review Letters. American Physical Society, 2011. https://doi.org/10.1103/PhysRevLett.106.243601.
ieee: C. Lang et al., “Observation of resonant photon blockade at microwave
frequencies using correlation function measurements,” Physical Review Letters,
vol. 106, no. 24. American Physical Society, 2011.
ista: Lang C, Bozyigit D, Eichler C, Steffen L, Fink JM, Abdumalikov A, Baur M,
Filipp S, Da Silva M, Blais A, Wallraff A. 2011. Observation of resonant photon
blockade at microwave frequencies using correlation function measurements. Physical
Review Letters. 106(24).
mla: Lang, C., et al. “Observation of Resonant Photon Blockade at Microwave Frequencies
Using Correlation Function Measurements.” Physical Review Letters, vol.
106, no. 24, American Physical Society, 2011, doi:10.1103/PhysRevLett.106.243601.
short: C. Lang, D. Bozyigit, C. Eichler, L. Steffen, J.M. Fink, A. Abdumalikov,
M. Baur, S. Filipp, M. Da Silva, A. Blais, A. Wallraff, Physical Review Letters
106 (2011).
date_created: 2018-12-11T11:53:57Z
date_published: 2011-06-15T00:00:00Z
date_updated: 2021-01-12T06:53:08Z
day: '15'
doi: 10.1103/PhysRevLett.106.243601
extern: 1
intvolume: ' 106'
issue: '24'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1102.0461
month: '06'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5336'
quality_controlled: 0
status: public
title: Observation of resonant photon blockade at microwave frequencies using correlation
function measurements
type: journal_article
volume: 106
year: '2011'
...
---
_id: '1780'
abstract:
- lang: eng
text: Continuous variable entanglement between two modes of a radiation field is
usually studied at optical frequencies. Here we demonstrate experiments that show
the entanglement between microwave photons of different energy in a broadband
squeezed beam. We use a Josephson parametric amplifier to generate the two-mode
correlated state and detect all four quadrature components simultaneously in a
two-channel heterodyne setup using amplitude detectors. Analyzing two-dimensional
phase space histograms for all possible pairs of quadratures allows us to determine
the full covariance matrix, which is in good agreement with the one expected for
a two-mode squeezed state.
acknowledgement: This work was supported by the European Research Council (ERC) through
a Starting grant and by ETHZ. S. F. acknowledges the Austrian Science Foundation
(FWF) for support
author:
- first_name: Christopher
full_name: Eichler, Christopher
last_name: Eichler
- first_name: Deniz
full_name: Bozyigit, Deniz
last_name: Bozyigit
- first_name: C
full_name: Lang, C
last_name: Lang
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Eichler C, Bozyigit D, Lang C, et al. Observation of two-mode squeezing in
the microwave frequency domain. Physical Review Letters. 2011;107(11).
doi:10.1103/PhysRevLett.107.113601
apa: Eichler, C., Bozyigit, D., Lang, C., Baur, M., Steffen, L., Fink, J. M., …
Wallraff, A. (2011). Observation of two-mode squeezing in the microwave frequency
domain. Physical Review Letters. American Physical Society. https://doi.org/10.1103/PhysRevLett.107.113601
chicago: Eichler, Christopher, Deniz Bozyigit, C Lang, Matthias Baur, L. Steffen,
Johannes M Fink, Stefan Filipp, and Andreas Wallraff. “Observation of Two-Mode
Squeezing in the Microwave Frequency Domain.” Physical Review Letters.
American Physical Society, 2011. https://doi.org/10.1103/PhysRevLett.107.113601.
ieee: C. Eichler et al., “Observation of two-mode squeezing in the microwave
frequency domain,” Physical Review Letters, vol. 107, no. 11. American
Physical Society, 2011.
ista: Eichler C, Bozyigit D, Lang C, Baur M, Steffen L, Fink JM, Filipp S, Wallraff
A. 2011. Observation of two-mode squeezing in the microwave frequency domain.
Physical Review Letters. 107(11).
mla: Eichler, Christopher, et al. “Observation of Two-Mode Squeezing in the Microwave
Frequency Domain.” Physical Review Letters, vol. 107, no. 11, American
Physical Society, 2011, doi:10.1103/PhysRevLett.107.113601.
short: C. Eichler, D. Bozyigit, C. Lang, M. Baur, L. Steffen, J.M. Fink, S. Filipp,
A. Wallraff, Physical Review Letters 107 (2011).
date_created: 2018-12-11T11:53:58Z
date_published: 2011-09-06T00:00:00Z
date_updated: 2021-01-12T06:53:09Z
day: '06'
doi: 10.1103/PhysRevLett.107.113601
extern: 1
intvolume: ' 107'
issue: '11'
month: '09'
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '5334'
quality_controlled: 0
status: public
title: Observation of two-mode squeezing in the microwave frequency domain
type: journal_article
volume: 107
year: '2011'
...
---
_id: '1781'
abstract:
- lang: eng
text: Microwave cavities with high quality factors enable coherent coupling of distant
quantum systems. Virtual photons lead to a transverse interaction between qubits
when they are nonresonant with the cavity but resonant with each other. We experimentally
investigate the inverse scaling of the interqubit coupling with the detuning from
a cavity mode and its proportionality to the qubit-cavity interaction strength.
We demonstrate that the enhanced coupling at higher frequencies is mediated by
multiple higher-harmonic cavity modes. Moreover, we observe dark states of the
coupled qubit-qubit system and analyze their relation to the symmetry of the applied
driving field at different frequencies.
acknowledgement: This work was supported by the Swiss National Science Foundation
(SNF), the Austrian Science Foundation (FWF), and ETH Zurich
author:
- first_name: Stefan
full_name: Filipp, Stefan
last_name: Filipp
- first_name: M
full_name: Göppl, M
last_name: Göppl
- first_name: Johannes M
full_name: Johannes Fink
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Matthias
full_name: Baur, Matthias P
last_name: Baur
- first_name: R
full_name: Bianchetti, R
last_name: Bianchetti
- first_name: L.
full_name: Steffen, L. Kraig
last_name: Steffen
- first_name: Andreas
full_name: Wallraff, Andreas
last_name: Wallraff
citation:
ama: Filipp S, Göppl M, Fink JM, et al. Multimode mediated qubit-qubit coupling
and dark-state symmetries in circuit quantum electrodynamics. Physical Review
A - Atomic, Molecular, and Optical Physics. 2011;83(6). doi:10.1103/PhysRevA.83.063827
apa: Filipp, S., Göppl, M., Fink, J. M., Baur, M., Bianchetti, R., Steffen, L.,
& Wallraff, A. (2011). Multimode mediated qubit-qubit coupling and dark-state
symmetries in circuit quantum electrodynamics. Physical Review A - Atomic,
Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.83.063827
chicago: Filipp, Stefan, M Göppl, Johannes M Fink, Matthias Baur, R Bianchetti,
L. Steffen, and Andreas Wallraff. “Multimode Mediated Qubit-Qubit Coupling and
Dark-State Symmetries in Circuit Quantum Electrodynamics.” Physical Review
A - Atomic, Molecular, and Optical Physics. American Physical Society, 2011.
https://doi.org/10.1103/PhysRevA.83.063827.
ieee: S. Filipp et al., “Multimode mediated qubit-qubit coupling and dark-state
symmetries in circuit quantum electrodynamics,” Physical Review A - Atomic,
Molecular, and Optical Physics, vol. 83, no. 6. American Physical Society,
2011.
ista: Filipp S, Göppl M, Fink JM, Baur M, Bianchetti R, Steffen L, Wallraff A. 2011.
Multimode mediated qubit-qubit coupling and dark-state symmetries in circuit quantum
electrodynamics. Physical Review A - Atomic, Molecular, and Optical Physics. 83(6).
mla: Filipp, Stefan, et al. “Multimode Mediated Qubit-Qubit Coupling and Dark-State
Symmetries in Circuit Quantum Electrodynamics.” Physical Review A - Atomic,
Molecular, and Optical Physics, vol. 83, no. 6, American Physical Society,
2011, doi:10.1103/PhysRevA.83.063827.
short: S. Filipp, M. Göppl, J.M. Fink, M. Baur, R. Bianchetti, L. Steffen, A. Wallraff,
Physical Review A - Atomic, Molecular, and Optical Physics 83 (2011).
date_created: 2018-12-11T11:53:58Z
date_published: 2011-06-22T00:00:00Z
date_updated: 2021-01-12T06:53:09Z
day: '22'
doi: 10.1103/PhysRevA.83.063827
extern: 1
intvolume: ' 83'
issue: '6'
month: '06'
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_status: published
publisher: American Physical Society
publist_id: '5335'
quality_controlled: 0
status: public
title: Multimode mediated qubit-qubit coupling and dark-state symmetries in circuit
quantum electrodynamics
type: journal_article
volume: 83
year: '2011'
...
---
_id: '1815'
abstract:
- lang: eng
text: Many membrane channels and receptors exhibit adaptive, or desensitized, response
to a strong sustained input stimulus, often supported by protein activity-dependent
inactivation. Adaptive response is thought to be related to various cellular functions
such as homeostasis and enlargement of dynamic range by background compensation.
Here we study the quantitative relation between adaptive response and background
compensation within a modeling framework. We show that any particular type of
adaptive response is neither sufficient nor necessary for adaptive enlargement
of dynamic range. In particular a precise adaptive response, where system activity
is maintained at a constant level at steady state, does not ensure a large dynamic
range neither in input signal nor in system output. A general mechanism for input
dynamic range enlargement can come about from the activity-dependent modulation
of protein responsiveness by multiple biochemical modification, regardless of
the type of adaptive response it induces. Therefore hierarchical biochemical processes
such as methylation and phosphorylation are natural candidates to induce this
property in signaling systems.
author:
- first_name: Tamar
full_name: Tamar Friedlander
id: 36A5845C-F248-11E8-B48F-1D18A9856A87
last_name: Friedlander
- first_name: Naama
full_name: Brenner, Naama
last_name: Brenner
citation:
ama: Friedlander T, Brenner N. Adaptive response and enlargement of dynamic range.
Mathematical Biosciences and Engineering. 2011;8(2):515-526. doi:10.3934/mbe.2011.8.515
apa: Friedlander, T., & Brenner, N. (2011). Adaptive response and enlargement
of dynamic range. Mathematical Biosciences and Engineering. Arizona State
University. https://doi.org/10.3934/mbe.2011.8.515
chicago: Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement
of Dynamic Range.” Mathematical Biosciences and Engineering. Arizona State
University, 2011. https://doi.org/10.3934/mbe.2011.8.515.
ieee: T. Friedlander and N. Brenner, “Adaptive response and enlargement of dynamic
range,” Mathematical Biosciences and Engineering, vol. 8, no. 2. Arizona
State University, pp. 515–526, 2011.
ista: Friedlander T, Brenner N. 2011. Adaptive response and enlargement of dynamic
range. Mathematical Biosciences and Engineering. 8(2), 515–526.
mla: Friedlander, Tamar, and Naama Brenner. “Adaptive Response and Enlargement of
Dynamic Range.” Mathematical Biosciences and Engineering, vol. 8, no. 2,
Arizona State University, 2011, pp. 515–26, doi:10.3934/mbe.2011.8.515.
short: T. Friedlander, N. Brenner, Mathematical Biosciences and Engineering 8 (2011)
515–526.
date_created: 2018-12-11T11:54:10Z
date_published: 2011-04-02T00:00:00Z
date_updated: 2021-01-12T06:53:23Z
day: '02'
doi: 10.3934/mbe.2011.8.515
extern: 1
intvolume: ' 8'
issue: '2'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1003.2791
month: '04'
oa: 1
page: 515 - 526
publication: Mathematical Biosciences and Engineering
publication_status: published
publisher: Arizona State University
publist_id: '5291'
quality_controlled: 0
status: public
title: Adaptive response and enlargement of dynamic range
type: journal_article
volume: 8
year: '2011'
...
---
_id: '1863'
abstract:
- lang: eng
text: The Levene model is the simplest mathematical model to describe the evolution
of gene frequencies in spatially subdivided populations. It provides insight into
how locally varying selection promotes a population’s genetic diversity. Despite
its simplicity, interesting problems have remained unsolved even in the diallelic
case. In this paper we answer an open problem by establishing that for two alleles
at one locus and J demes, up to 2J−1 polymorphic equilibria may coexist. We first
present a proof for the case of stable monomorphisms and then show that the result
also holds for protected alleles. These findings allow us to prove that any odd
number (up to 2J−1) of equilibria is possible, before we extend the proof to even
numbers. We conclude with some numerical results and show that for J>2, the
proportion of parameter space affording this maximum is extremely small.
acknowledgement: FWF 21305
author:
- first_name: Sebastian
full_name: Sebastian Novak
id: 461468AE-F248-11E8-B48F-1D18A9856A87
last_name: Novak
citation:
ama: Novak S. The number of equilibria in the diallelic Levene model with multiple
demes. Theoretical Population Biology. 2011;79(3):97-101. doi:10.1016/j.tpb.2010.12.002
apa: Novak, S. (2011). The number of equilibria in the diallelic Levene model with
multiple demes. Theoretical Population Biology. Academic Press. https://doi.org/10.1016/j.tpb.2010.12.002
chicago: Novak, Sebastian. “The Number of Equilibria in the Diallelic Levene Model
with Multiple Demes.” Theoretical Population Biology. Academic Press, 2011.
https://doi.org/10.1016/j.tpb.2010.12.002.
ieee: S. Novak, “The number of equilibria in the diallelic Levene model with multiple
demes,” Theoretical Population Biology, vol. 79, no. 3. Academic Press,
pp. 97–101, 2011.
ista: Novak S. 2011. The number of equilibria in the diallelic Levene model with
multiple demes. Theoretical Population Biology. 79(3), 97–101.
mla: Novak, Sebastian. “The Number of Equilibria in the Diallelic Levene Model with
Multiple Demes.” Theoretical Population Biology, vol. 79, no. 3, Academic
Press, 2011, pp. 97–101, doi:10.1016/j.tpb.2010.12.002.
short: S. Novak, Theoretical Population Biology 79 (2011) 97–101.
date_created: 2018-12-11T11:54:25Z
date_published: 2011-05-01T00:00:00Z
date_updated: 2021-01-12T06:53:42Z
day: '01'
doi: 10.1016/j.tpb.2010.12.002
extern: 1
intvolume: ' 79'
issue: '3'
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '05'
page: 97 - 101
publication: Theoretical Population Biology
publication_status: published
publisher: Academic Press
publist_id: '5236'
quality_controlled: 0
status: public
title: The number of equilibria in the diallelic Levene model with multiple demes
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
volume: 79
year: '2011'
...
---
_id: '1973'
abstract:
- lang: eng
text: Complex I is the first and largest enzyme of the respiratory chain, coupling
electron transfer between NADH and ubiquinone to the translocation of four protons
across the membrane. It has a central role in cellular energy production and has
been implicated in many human neurodegenerative diseases. The L-shaped enzyme
consists of hydrophilic and membrane domains. Previously, we determined the structure
of the hydrophilic domain. Here we report the crystal structure of the Esherichia
coli complex I membrane domain at 3.0 Ã. resolution. It includes six subunits,
NuoL, NuoM, NuoN, NuoA, NuoJ and NuoK, with 55 transmembrane helices. The fold
of the homologous antiporter-like subunits L, M and N is novel, with two inverted
structural repeats of five transmembrane helices arranged, unusually, face-to-back.
Each repeat includes a discontinuous transmembrane helix and forms half of a channel
across the membrane. A network of conserved polar residues connects the two half-channels,
completing the proton translocation pathway. Unexpectedly, lysines rather than
carboxylate residues act as the main elements of the proton pump in these subunits.
The fourth probable proton-translocation channel is at the interface of subunits
N, K, J and A. The structure indicates that proton translocation in complex I,
uniquely, involves coordinated conformational changes in six symmetrical structural
elements.
acknowledgement: This work was funded by the Medical Research Council.
author:
- first_name: Rouslan
full_name: Efremov, Rouslan G
last_name: Efremov
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Efremov R, Sazanov LA. Structure of the membrane domain of respiratory complex
i. Nature. 2011;476(7361):414-421. doi:10.1038/nature10330
apa: Efremov, R., & Sazanov, L. A. (2011). Structure of the membrane domain
of respiratory complex i. Nature. Nature Publishing Group. https://doi.org/10.1038/nature10330
chicago: Efremov, Rouslan, and Leonid A Sazanov. “Structure of the Membrane Domain
of Respiratory Complex I.” Nature. Nature Publishing Group, 2011. https://doi.org/10.1038/nature10330.
ieee: R. Efremov and L. A. Sazanov, “Structure of the membrane domain of respiratory
complex i,” Nature, vol. 476, no. 7361. Nature Publishing Group, pp. 414–421,
2011.
ista: Efremov R, Sazanov LA. 2011. Structure of the membrane domain of respiratory
complex i. Nature. 476(7361), 414–421.
mla: Efremov, Rouslan, and Leonid A. Sazanov. “Structure of the Membrane Domain
of Respiratory Complex I.” Nature, vol. 476, no. 7361, Nature Publishing
Group, 2011, pp. 414–21, doi:10.1038/nature10330.
short: R. Efremov, L.A. Sazanov, Nature 476 (2011) 414–421.
date_created: 2018-12-11T11:54:59Z
date_published: 2011-08-25T00:00:00Z
date_updated: 2021-01-12T06:54:26Z
day: '25'
doi: 10.1038/nature10330
extern: 1
intvolume: ' 476'
issue: '7361'
month: '08'
page: 414 - 421
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '5110'
quality_controlled: 0
status: public
title: Structure of the membrane domain of respiratory complex i
type: journal_article
volume: 476
year: '2011'
...
---
_id: '1974'
abstract:
- lang: eng
text: Complex I is the first enzyme of the respiratory chain and plays a central
role in cellular energy production. It has been implicated in many human neurodegenerative
diseases, as well as in ageing. One of the biggest membrane protein complexes,
it is an L-shaped assembly consisting of hydrophilic and membrane domains. Previously,
we have determined structures of the hydrophilic domain in several redox states.
Last year was marked by fascinating breakthroughs in the understanding of the
complete structure. We described the architecture of the membrane domain and of
the entire bacterial complex I. X-ray analysis of the larger mitochondrial enzyme
has also been published. The core subunits of the bacterial and mitochondrial
enzymes have remarkably similar structures. The proposed mechanism of coupling
between electron transfer and proton translocation involves long-range conformational
changes, coordinated in part by a long α-helix, akin to the coupling rod of a
steam engine.
acknowledgement: The work in authors’ laboratory was funded by the Medical Research
Council.
author:
- first_name: Rouslan
full_name: Efremov, Rouslan G
last_name: Efremov
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: 'Efremov R, Sazanov LA. Respiratory complex I: “steam engine” of the cell?
Current Opinion in Structural Biology. 2011;21(4):532-540. doi:10.1016/j.sbi.2011.07.002'
apa: 'Efremov, R., & Sazanov, L. A. (2011). Respiratory complex I: “steam engine”
of the cell? Current Opinion in Structural Biology. Elsevier. https://doi.org/10.1016/j.sbi.2011.07.002'
chicago: 'Efremov, Rouslan, and Leonid A Sazanov. “Respiratory Complex I: ‘steam
Engine’ of the Cell?” Current Opinion in Structural Biology. Elsevier,
2011. https://doi.org/10.1016/j.sbi.2011.07.002.'
ieee: 'R. Efremov and L. A. Sazanov, “Respiratory complex I: ‘steam engine’ of the
cell?,” Current Opinion in Structural Biology, vol. 21, no. 4. Elsevier,
pp. 532–540, 2011.'
ista: 'Efremov R, Sazanov LA. 2011. Respiratory complex I: ‘steam engine’ of the
cell? Current Opinion in Structural Biology. 21(4), 532–540.'
mla: 'Efremov, Rouslan, and Leonid A. Sazanov. “Respiratory Complex I: ‘steam Engine’
of the Cell?” Current Opinion in Structural Biology, vol. 21, no. 4, Elsevier,
2011, pp. 532–40, doi:10.1016/j.sbi.2011.07.002.'
short: R. Efremov, L.A. Sazanov, Current Opinion in Structural Biology 21 (2011)
532–540.
date_created: 2018-12-11T11:54:59Z
date_published: 2011-08-01T00:00:00Z
date_updated: 2021-01-12T06:54:27Z
day: '01'
doi: 10.1016/j.sbi.2011.07.002
extern: 1
intvolume: ' 21'
issue: '4'
month: '08'
page: 532 - 540
publication: Current Opinion in Structural Biology
publication_status: published
publisher: Elsevier
publist_id: '5111'
quality_controlled: 0
status: public
title: 'Respiratory complex I: ''steam engine'' of the cell?'
type: journal_article
volume: 21
year: '2011'
...
---
_id: '1975'
abstract:
- lang: eng
text: 'Modern α-proteobacteria are thought to be closely related to the ancient
symbiont of eukaryotes, an ancestor of mitochondria. Respiratory complex I from
α-proteobacteria and mitochondria is well conserved at the level of the 14 "core"
subunits, consistent with that notion. Mitochondrial complex I contains the core
subunits, present in all species, and up to 31 "supernumerary" subunits,
generally thought to have originated only within eukaryotic lineages. However,
the full protein composition of an α-proteobacterial complex I has not been established
previously. Here, we report the first purification and characterization of complex
I from the α-proteobacterium Paracoccus denitrificans. Single particle electron
microscopy shows that the complex has a well defined L-shape. Unexpectedly, in
addition to the 14 core subunits, the enzyme also contains homologues of three
supernumerary mitochondrial subunits as follows: B17.2, AQDQ/18, and 13 kDa (bovine
nomenclature). This finding suggests that evolution of complex I via addition
of supernumerary or "accessory" subunits started before the original
endosymbiotic event that led to the creation of the eukaryotic cell. It also provides
further confirmation that α-proteobacteria are the closest extant relatives of
mitochondria.'
acknowledgement: 'This work was supported by the Medical Research Council. '
author:
- first_name: Chui
full_name: Yip, Chui Y
last_name: Yip
- first_name: Michael
full_name: Harbour, Michael E
last_name: Harbour
- first_name: Kamburapola
full_name: Jayawardena, Kamburapola G
last_name: Jayawardena
- first_name: Ian
full_name: Fearnley, Ian M
last_name: Fearnley
- first_name: Leonid A
full_name: Leonid Sazanov
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. Evolution of respiratory
complex I "Supernumerary" subunits are present in the α-proteobacterial
enzyme. Journal of Biological Chemistry. 2011;286(7):5023-5033. doi:10.1074/jbc.M110.194993
apa: Yip, C., Harbour, M., Jayawardena, K., Fearnley, I., & Sazanov, L. A. (2011).
Evolution of respiratory complex I "Supernumerary" subunits
are present in the α-proteobacterial enzyme. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M110.194993
chicago: Yip, Chui, Michael Harbour, Kamburapola Jayawardena, Ian Fearnley, and
Leonid A Sazanov. “Evolution of Respiratory Complex I "Supernumerary"
Subunits Are Present in the α-Proteobacterial Enzyme.” Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology, 2011.
https://doi.org/10.1074/jbc.M110.194993.
ieee: C. Yip, M. Harbour, K. Jayawardena, I. Fearnley, and L. A. Sazanov, “Evolution
of respiratory complex I "Supernumerary" subunits are present
in the α-proteobacterial enzyme,” Journal of Biological Chemistry, vol.
286, no. 7. American Society for Biochemistry and Molecular Biology, pp. 5023–5033,
2011.
ista: Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. 2011. Evolution of
respiratory complex I "Supernumerary" subunits are present in
the α-proteobacterial enzyme. Journal of Biological Chemistry. 286(7), 5023–5033.
mla: Yip, Chui, et al. “Evolution of Respiratory Complex I "Supernumerary"
Subunits Are Present in the α-Proteobacterial Enzyme.” Journal of Biological
Chemistry, vol. 286, no. 7, American Society for Biochemistry and Molecular
Biology, 2011, pp. 5023–33, doi:10.1074/jbc.M110.194993.
short: C. Yip, M. Harbour, K. Jayawardena, I. Fearnley, L.A. Sazanov, Journal of
Biological Chemistry 286 (2011) 5023–5033.
date_created: 2018-12-11T11:55:00Z
date_published: 2011-02-18T00:00:00Z
date_updated: 2021-01-12T06:54:27Z
day: '18'
doi: 10.1074/jbc.M110.194993
extern: 1
intvolume: ' 286'
issue: '7'
month: '02'
page: 5023 - 5033
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '5112'
quality_controlled: 0
status: public
title: Evolution of respiratory complex I "Supernumerary" subunits are present
in the α-proteobacterial enzyme
type: journal_article
volume: 286
year: '2011'
...
---
_id: '1985'
abstract:
- lang: eng
text: |2-
In Escherichia coli, the pole-to-pole oscillation of the Min proteins directs septum formation to midcell, which is required for symmetric cell division. In vitro, protein waves emerge from the self-organization of MinD, a membrane-binding ATPase, and its activator MinE. For wave propagation, the proteins need to cycle through states of collective membrane binding and unbinding. Although MinD presumably undergoes cooperative membrane attachment, it is unclear how synchronous detachment is coordinated. We used confocal and single-molecule microscopy to elucidate the order of events during Min wave propagation. We propose that protein detachment at the rear of the wave, and the formation of the E-ring, are accomplished by two complementary processes: first, local accumulation of MinE due to rapid rebinding, leading to dynamic instability; and second, a structural change induced by membrane-interaction of MinE in an equimolar MinD-MinE (MinDE) complex, which supports the robustness of pattern formation.
acknowledgement: This work was also supported by the Max Planck Society (M.L., E.F.-F.,
P.S.).
author:
- first_name: Martin
full_name: Martin Loose
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Elisabeth
full_name: Fischer-Friedrich, Elisabeth
last_name: Fischer Friedrich
- first_name: Christoph
full_name: Herold, Christoph
last_name: Herold
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Petra
full_name: 'Schwille, Petra '
last_name: Schwille
citation:
ama: Loose M, Fischer Friedrich E, Herold C, Kruse K, Schwille P. Min protein patterns
emerge from rapid rebinding and membrane interaction of MinE. Nature Structural
and Molecular Biology. 2011;18(5):577-583. doi:10.1038/nsmb.2037
apa: Loose, M., Fischer Friedrich, E., Herold, C., Kruse, K., & Schwille, P.
(2011). Min protein patterns emerge from rapid rebinding and membrane interaction
of MinE. Nature Structural and Molecular Biology. Nature Publishing Group.
https://doi.org/10.1038/nsmb.2037
chicago: Loose, Martin, Elisabeth Fischer Friedrich, Christoph Herold, Karsten Kruse,
and Petra Schwille. “Min Protein Patterns Emerge from Rapid Rebinding and Membrane
Interaction of MinE.” Nature Structural and Molecular Biology. Nature Publishing
Group, 2011. https://doi.org/10.1038/nsmb.2037.
ieee: M. Loose, E. Fischer Friedrich, C. Herold, K. Kruse, and P. Schwille, “Min
protein patterns emerge from rapid rebinding and membrane interaction of MinE,”
Nature Structural and Molecular Biology, vol. 18, no. 5. Nature Publishing
Group, pp. 577–583, 2011.
ista: Loose M, Fischer Friedrich E, Herold C, Kruse K, Schwille P. 2011. Min protein
patterns emerge from rapid rebinding and membrane interaction of MinE. Nature
Structural and Molecular Biology. 18(5), 577–583.
mla: Loose, Martin, et al. “Min Protein Patterns Emerge from Rapid Rebinding and
Membrane Interaction of MinE.” Nature Structural and Molecular Biology,
vol. 18, no. 5, Nature Publishing Group, 2011, pp. 577–83, doi:10.1038/nsmb.2037.
short: M. Loose, E. Fischer Friedrich, C. Herold, K. Kruse, P. Schwille, Nature
Structural and Molecular Biology 18 (2011) 577–583.
date_created: 2018-12-11T11:55:03Z
date_published: 2011-05-01T00:00:00Z
date_updated: 2021-01-12T06:54:31Z
day: '01'
doi: 10.1038/nsmb.2037
extern: 1
intvolume: ' 18'
issue: '5'
month: '05'
page: 577 - 583
publication: Nature Structural and Molecular Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '5098'
quality_controlled: 0
status: public
title: Min protein patterns emerge from rapid rebinding and membrane interaction of
MinE
type: journal_article
volume: 18
year: '2011'
...
---
_id: '1986'
abstract:
- lang: eng
text: One of the most fundamental features of biological systems is probably their
ability to self-organize in space and time on different scales. Despite many elaborate
theoretical models of how molecular self-organization can come about, only a few
experimental systems of biological origin have so far been rigorously described,
due mostly to their inherent complexity. The most promising strategy of modern
biophysics is thus to identify minimal biological systems showing self-organized
emergent behavior. One of the best-understood examples of protein self-organization,
which has recently been successfully reconstituted in vitro, is represented by
the oscillations of the Min proteins in Escherichia coli. In this review, we summarize
the current understanding of the mechanism of Min protein self-organization in
vivo and in vitro. We discuss the potential of the Min oscillations to sense the
geometry of the cell and suggest that spontaneous protein waves could be a general
means of intracellular organization. We hypothesize that cooperative membrane
binding and unbinding, e.g., as an energy-dependent switch, may act as an important
regulatory mechanism for protein oscillations and pattern formation in the cell.
author:
- first_name: Martin
full_name: Martin Loose
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Petra
full_name: 'Schwille, Petra '
last_name: Schwille
citation:
ama: 'Loose M, Kruse K, Schwille P. Protein self-organization: Lessons from the
min system. Annual Review of Biophysics. 2011;40(1):315-336. doi:10.1146/annurev-biophys-042910-155332'
apa: 'Loose, M., Kruse, K., & Schwille, P. (2011). Protein self-organization:
Lessons from the min system. Annual Review of Biophysics. Annual Reviews.
https://doi.org/10.1146/annurev-biophys-042910-155332'
chicago: 'Loose, Martin, Karsten Kruse, and Petra Schwille. “Protein Self-Organization:
Lessons from the Min System.” Annual Review of Biophysics. Annual Reviews,
2011. https://doi.org/10.1146/annurev-biophys-042910-155332.'
ieee: 'M. Loose, K. Kruse, and P. Schwille, “Protein self-organization: Lessons
from the min system,” Annual Review of Biophysics, vol. 40, no. 1. Annual
Reviews, pp. 315–336, 2011.'
ista: 'Loose M, Kruse K, Schwille P. 2011. Protein self-organization: Lessons from
the min system. Annual Review of Biophysics. 40(1), 315–336.'
mla: 'Loose, Martin, et al. “Protein Self-Organization: Lessons from the Min System.”
Annual Review of Biophysics, vol. 40, no. 1, Annual Reviews, 2011, pp.
315–36, doi:10.1146/annurev-biophys-042910-155332.'
short: M. Loose, K. Kruse, P. Schwille, Annual Review of Biophysics 40 (2011) 315–336.
date_created: 2018-12-11T11:55:04Z
date_published: 2011-06-09T00:00:00Z
date_updated: 2021-01-12T06:54:31Z
day: '09'
doi: 10.1146/annurev-biophys-042910-155332
extern: 1
intvolume: ' 40'
issue: '1'
month: '06'
page: 315 - 336
publication: Annual Review of Biophysics
publication_status: published
publisher: Annual Reviews
publist_id: '5097'
quality_controlled: 0
status: public
title: 'Protein self-organization: Lessons from the min system'
type: journal_article
volume: 40
year: '2011'
...
---
_id: '14305'
abstract:
- lang: eng
text: Understanding the mechanism of protein folding requires a detailed knowledge
of the structural properties of the barriers separating unfolded from native conformations.
The S-peptide from ribonuclease S forms its α-helical structure only upon binding
to the folded S-protein. We characterized the transition state for this binding-induced
folding reaction at high resolution by determining the effect of site-specific
backbone thioxylation and side-chain modifications on the kinetics and thermodynamics
of the reaction, which allows us to monitor formation of backbone hydrogen bonds
and side-chain interactions in the transition state. The experiments reveal that
α-helical structure in the S-peptide is absent in the transition state of binding.
Recognition between the unfolded S-peptide and the S-protein is mediated by loosely
packed hydrophobic side-chain interactions in two well defined regions on the
S-peptide. Close packing and helix formation occurs rapidly after binding. Introducing
hydrophobic residues at positions outside the recognition region can drastically
slow down association.
article_processing_charge: No
article_type: original
author:
- first_name: Annett
full_name: Bachmann, Annett
last_name: Bachmann
- first_name: Dirk
full_name: Wildemann, Dirk
last_name: Wildemann
- first_name: Florian M
full_name: Praetorius, Florian M
id: dfec9381-4341-11ee-8fd8-faa02bba7d62
last_name: Praetorius
- first_name: Gunter
full_name: Fischer, Gunter
last_name: Fischer
- first_name: Thomas
full_name: Kiefhaber, Thomas
last_name: Kiefhaber
citation:
ama: Bachmann A, Wildemann D, Praetorius FM, Fischer G, Kiefhaber T. Mapping backbone
and side-chain interactions in the transition state of a coupled protein folding
and binding reaction. PNAS. 2011;108(10):3952-3957. doi:10.1073/pnas.1012668108
apa: Bachmann, A., Wildemann, D., Praetorius, F. M., Fischer, G., & Kiefhaber,
T. (2011). Mapping backbone and side-chain interactions in the transition state
of a coupled protein folding and binding reaction. PNAS. Proceedings of
the National Academy of Sciences. https://doi.org/10.1073/pnas.1012668108
chicago: Bachmann, Annett, Dirk Wildemann, Florian M Praetorius, Gunter Fischer,
and Thomas Kiefhaber. “Mapping Backbone and Side-Chain Interactions in the Transition
State of a Coupled Protein Folding and Binding Reaction.” PNAS. Proceedings
of the National Academy of Sciences, 2011. https://doi.org/10.1073/pnas.1012668108.
ieee: A. Bachmann, D. Wildemann, F. M. Praetorius, G. Fischer, and T. Kiefhaber,
“Mapping backbone and side-chain interactions in the transition state of a coupled
protein folding and binding reaction,” PNAS, vol. 108, no. 10. Proceedings
of the National Academy of Sciences, pp. 3952–3957, 2011.
ista: Bachmann A, Wildemann D, Praetorius FM, Fischer G, Kiefhaber T. 2011. Mapping
backbone and side-chain interactions in the transition state of a coupled protein
folding and binding reaction. PNAS. 108(10), 3952–3957.
mla: Bachmann, Annett, et al. “Mapping Backbone and Side-Chain Interactions in the
Transition State of a Coupled Protein Folding and Binding Reaction.” PNAS,
vol. 108, no. 10, Proceedings of the National Academy of Sciences, 2011, pp. 3952–57,
doi:10.1073/pnas.1012668108.
short: A. Bachmann, D. Wildemann, F.M. Praetorius, G. Fischer, T. Kiefhaber, PNAS
108 (2011) 3952–3957.
date_created: 2023-09-06T12:54:36Z
date_published: 2011-01-12T00:00:00Z
date_updated: 2023-11-07T11:50:29Z
day: '12'
doi: 10.1073/pnas.1012668108
extern: '1'
external_id:
pmid:
- '21325613'
intvolume: ' 108'
issue: '10'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1073/pnas.1012668108
month: '01'
oa: 1
oa_version: Published Version
page: 3952-3957
pmid: 1
publication: PNAS
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mapping backbone and side-chain interactions in the transition state of a coupled
protein folding and binding reaction
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 108
year: '2011'
...
---
_id: '1467'
abstract:
- lang: eng
text: We propose a general conjecture for the mixed Hodge polynomial of the generic
character varieties of representations of the fundamental group of a Riemann surface
of genus g to GLn(C) with fixed generic semisimple conjugacy classes at k punctures.
This conjecture generalizes the Cauchy identity for Macdonald polynomials and
is a common generalization of two formulas that we prove in this paper. The first
is a formula for the E-polynomial of these character varieties which we obtain
using the character table of GLn(Fq). We use this formula to compute the Euler
characteristic of character varieties. The second formula gives the Poincaré polynomial
of certain associated quiver varieties which we obtain using the character table
of gln(Fq). In the last main result we prove that the Poincaré polynomials of
the quiver varieties equal certain multiplicities in the tensor product of irreducible
characters of GLn(Fq). As a consequence we find a curious connection between Kac-Moody
algebras associated with comet-shaped, and typically wild, quivers and the representation
theory of GLn(Fq).
acknowledgement: |-
Hausel’s work was supported by National Science Foundation grants DMS-0305505 and DMS-0604775, by an Alfred Sloan Fellowship, and by a Royal Society University Research Fellowship. Letellier’s work supported by Agence Nationale de la Recherche grant ANR-09-JCJC-0102-01.
Rodriguez-Villegas’s work supported by National Science Foundation grant DMS-0200605, by an FRA from the University of Texas at Austin, by EPSRC grant EP/G027110/1, by visiting fellowships at All Souls and Wadham Colleges in Oxford, and by a Research Scholarship from the Clay Mathematical Institute.
author:
- first_name: Tamas
full_name: Tamas Hausel
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Emmanuel
full_name: Letellier, Emmanuel
last_name: Letellier
- first_name: Fernando
full_name: Rodríguez Villegas, Fernando
last_name: Rodríguez Villegas
citation:
ama: Hausel T, Letellier E, Rodríguez Villegas F. Arithmetic harmonic analysis on
character and quiver varieties. Duke Mathematical Journal. 2011;160(2):323-400.
doi:10.1215/00127094-1444258
apa: Hausel, T., Letellier, E., & Rodríguez Villegas, F. (2011). Arithmetic
harmonic analysis on character and quiver varieties. Duke Mathematical Journal.
Duke University Press. https://doi.org/10.1215/00127094-1444258
chicago: Hausel, Tamás, Emmanuel Letellier, and Fernando Rodríguez Villegas. “Arithmetic
Harmonic Analysis on Character and Quiver Varieties.” Duke Mathematical Journal.
Duke University Press, 2011. https://doi.org/10.1215/00127094-1444258.
ieee: T. Hausel, E. Letellier, and F. Rodríguez Villegas, “Arithmetic harmonic analysis
on character and quiver varieties,” Duke Mathematical Journal, vol. 160,
no. 2. Duke University Press, pp. 323–400, 2011.
ista: Hausel T, Letellier E, Rodríguez Villegas F. 2011. Arithmetic harmonic analysis
on character and quiver varieties. Duke Mathematical Journal. 160(2), 323–400.
mla: Hausel, Tamás, et al. “Arithmetic Harmonic Analysis on Character and Quiver
Varieties.” Duke Mathematical Journal, vol. 160, no. 2, Duke University
Press, 2011, pp. 323–400, doi:10.1215/00127094-1444258.
short: T. Hausel, E. Letellier, F. Rodríguez Villegas, Duke Mathematical Journal
160 (2011) 323–400.
date_created: 2018-12-11T11:52:11Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T06:50:56Z
day: '01'
doi: 10.1215/00127094-1444258
extern: 1
intvolume: ' 160'
issue: '2'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/0810.2076
month: '01'
oa: 1
page: 323 - 400
publication: Duke Mathematical Journal
publication_status: published
publisher: Duke University Press
publist_id: '5728'
quality_controlled: 0
status: public
title: Arithmetic harmonic analysis on character and quiver varieties
type: journal_article
volume: 160
year: '2011'
...