---
_id: '2458'
abstract:
- lang: eng
  text: Initiation and successive development of organs induce mechanical stresses
    at the cellular level. Using the tomato shoot apex, a new study now proposes that
    mechanical strain regulates the plasma membrane abundance of the PIN1 auxin transporter,
    thereby reinforcing a positive feed-back loop between growth and auxin accumulation.
author:
- first_name: Hongjiang
  full_name: Li, Hongjiang
  id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0001-5039-9660
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Wim
  full_name: Grunewald, Wim
  last_name: Grunewald
citation:
  ama: 'Li H, Friml J, Grunewald W. Cell polarity: Stretching prevents developmental
    cramps. <i>Current Biology</i>. 2012;22(16):R635-R637. doi:<a href="https://doi.org/10.1016/j.cub.2012.06.053">10.1016/j.cub.2012.06.053</a>'
  apa: 'Li, H., Friml, J., &#38; Grunewald, W. (2012). Cell polarity: Stretching prevents
    developmental cramps. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2012.06.053">https://doi.org/10.1016/j.cub.2012.06.053</a>'
  chicago: 'Li, Hongjiang, Jiří Friml, and Wim Grunewald. “Cell Polarity: Stretching
    Prevents Developmental Cramps.” <i>Current Biology</i>. Cell Press, 2012. <a href="https://doi.org/10.1016/j.cub.2012.06.053">https://doi.org/10.1016/j.cub.2012.06.053</a>.'
  ieee: 'H. Li, J. Friml, and W. Grunewald, “Cell polarity: Stretching prevents developmental
    cramps,” <i>Current Biology</i>, vol. 22, no. 16. Cell Press, pp. R635–R637, 2012.'
  ista: 'Li H, Friml J, Grunewald W. 2012. Cell polarity: Stretching prevents developmental
    cramps. Current Biology. 22(16), R635–R637.'
  mla: 'Li, Hongjiang, et al. “Cell Polarity: Stretching Prevents Developmental Cramps.”
    <i>Current Biology</i>, vol. 22, no. 16, Cell Press, 2012, pp. R635–37, doi:<a
    href="https://doi.org/10.1016/j.cub.2012.06.053">10.1016/j.cub.2012.06.053</a>.'
  short: H. Li, J. Friml, W. Grunewald, Current Biology 22 (2012) R635–R637.
date_created: 2018-12-11T11:57:47Z
date_published: 2012-08-21T00:00:00Z
date_updated: 2021-01-12T06:57:36Z
day: '21'
doi: 10.1016/j.cub.2012.06.053
extern: '1'
intvolume: '        22'
issue: '16'
language:
- iso: eng
month: '08'
oa_version: None
page: R635 - R637
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '4445'
quality_controlled: '1'
status: public
title: 'Cell polarity: Stretching prevents developmental cramps'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '2459'
abstract:
- lang: eng
  text: Coordinated, subcellular trafficking of proteins is one of the fundamental
    properties of the multicellular eukaryotic organisms. Trafficking involves a large
    diversity of compartments, pathways, cargo molecules, and vesicle-sorting events.
    It is also crucial in regulating the localization and, thus, the activity of various
    proteins, but the process is still poorly genetically defined in plants. In the
    past, forward genetics screens had been used to determine the function of genes
    by searching for a specific morphological phenotype in the organism population
    in which mutations had been induced chemically or by irradiation. Unfortunately,
    these straightforward genetic screens turned out to be limited in identifying
    new regulators of intracellular protein transport, because mutations affecting
    essential trafficking pathways often lead to lethality. In addition, the use of
    these approaches has been restricted by functional redundancy among trafficking
    regulators. Screens for mutants that rely on the observation of changes in the
    cellular localization or dynamics of fluorescent subcellular markers enable, at
    least partially, to circumvent these issues. Hence, such image-based screens provide
    the possibility to identify either alleles with weak effects or components of
    the subcellular trafficking machinery that have no strong impact on the plant
    growth.
article_number: '97'
author:
- first_name: Marta
  full_name: Zwiewka, Marta
  last_name: Zwiewka
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Zwiewka M, Friml J. Fluorescence imaging-based forward genetic screens to identify
    trafficking regulators in plants. <i>Frontiers in Plant Science</i>. 2012;3(May).
    doi:<a href="https://doi.org/10.3389/fpls.2012.00097">10.3389/fpls.2012.00097</a>
  apa: Zwiewka, M., &#38; Friml, J. (2012). Fluorescence imaging-based forward genetic
    screens to identify trafficking regulators in plants. <i>Frontiers in Plant Science</i>.
    Frontiers Research Foundation. <a href="https://doi.org/10.3389/fpls.2012.00097">https://doi.org/10.3389/fpls.2012.00097</a>
  chicago: Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic
    Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>.
    Frontiers Research Foundation, 2012. <a href="https://doi.org/10.3389/fpls.2012.00097">https://doi.org/10.3389/fpls.2012.00097</a>.
  ieee: M. Zwiewka and J. Friml, “Fluorescence imaging-based forward genetic screens
    to identify trafficking regulators in plants,” <i>Frontiers in Plant Science</i>,
    vol. 3, no. May. Frontiers Research Foundation, 2012.
  ista: Zwiewka M, Friml J. 2012. Fluorescence imaging-based forward genetic screens
    to identify trafficking regulators in plants. Frontiers in Plant Science. 3(May),
    97.
  mla: Zwiewka, Marta, and Jiří Friml. “Fluorescence Imaging-Based Forward Genetic
    Screens to Identify Trafficking Regulators in Plants.” <i>Frontiers in Plant Science</i>,
    vol. 3, no. May, 97, Frontiers Research Foundation, 2012, doi:<a href="https://doi.org/10.3389/fpls.2012.00097">10.3389/fpls.2012.00097</a>.
  short: M. Zwiewka, J. Friml, Frontiers in Plant Science 3 (2012).
date_created: 2018-12-11T11:57:47Z
date_published: 2012-05-24T00:00:00Z
date_updated: 2021-01-12T06:57:36Z
day: '24'
ddc:
- '580'
doi: 10.3389/fpls.2012.00097
extern: '1'
file:
- access_level: open_access
  checksum: ab4e9487ccdb83a7a0a9ee6811521844
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-04-26T06:49:26Z
  date_updated: 2020-07-14T12:45:41Z
  file_id: '6346'
  file_name: 2012_frontiers_Zwiewka.pdf
  file_size: 1468230
  relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: '         3'
issue: May
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '05'
oa: 1
oa_version: Published Version
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '4444'
quality_controlled: '1'
status: public
title: Fluorescence imaging-based forward genetic screens to identify trafficking
  regulators in plants
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2012'
...
---
_id: '2474'
abstract:
- lang: eng
  text: 'Interneurons are critical for neuronal circuit function, but how their dendritic
    morphologies and membrane properties influence information flow within neuronal
    circuits is largely unknown. We studied the spatiotemporal profile of synaptic
    integration and short-term plasticity in dendrites of mature cerebellar stellate
    cells by combining two-photon guided electrical stimulation, glutamate uncaging,
    electron microscopy, and modeling. Synaptic activation within thin (0.4 μm) dendrites
    produced somatic responses that became smaller and slower with increasing distance
    from the soma, sublinear subthreshold input-output relationships, and a somatodendritic
    gradient of short-term plasticity. Unlike most studies showing that neurons employ
    active dendritic mechanisms, we found that passive cable properties of thin dendrites
    determine the sublinear integration and plasticity gradient, which both result
    from large dendritic depolarizations that reduce synaptic driving force. These
    integrative properties allow stellate cells to act as spatiotemporal filters of
    synaptic input patterns, thereby biasing their output in favor of sparse presynaptic
    activity. Stellate cells are critical sources of inhibition in the cerebellum,
    but how their dendrites integrate excitatory synaptic inputs is unknown. Abrahamsson
    et al. show that thin dendrites and passive membrane properties of SCs promote
    sublinear synaptic summation and distance-dependent short-term plasticity. '
author:
- first_name: Therese
  full_name: Abrahamsson, Therese
  last_name: Abrahamsson
- first_name: Laurence
  full_name: Cathala, Laurence
  last_name: Cathala
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: David
  full_name: DiGregorio, David A
  last_name: Digregorio
citation:
  ama: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. Thin dendrites
    of cerebellar interneurons confer sublinear synaptic integration and a gradient
    of short-term plasticity. <i>Neuron</i>. 2012;73(6):1159-1172. doi:<a href="https://doi.org/10.1016/j.neuron.2012.01.027">10.1016/j.neuron.2012.01.027</a>
  apa: Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., &#38; Digregorio,
    D. (2012). Thin dendrites of cerebellar interneurons confer sublinear synaptic
    integration and a gradient of short-term plasticity. <i>Neuron</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.neuron.2012.01.027">https://doi.org/10.1016/j.neuron.2012.01.027</a>
  chicago: Abrahamsson, Therese, Laurence Cathala, Ko Matsui, Ryuichi Shigemoto, and
    David Digregorio. “Thin Dendrites of Cerebellar Interneurons Confer Sublinear
    Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>.
    Elsevier, 2012. <a href="https://doi.org/10.1016/j.neuron.2012.01.027">https://doi.org/10.1016/j.neuron.2012.01.027</a>.
  ieee: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, and D. Digregorio, “Thin
    dendrites of cerebellar interneurons confer sublinear synaptic integration and
    a gradient of short-term plasticity,” <i>Neuron</i>, vol. 73, no. 6. Elsevier,
    pp. 1159–1172, 2012.
  ista: Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio D. 2012. Thin
    dendrites of cerebellar interneurons confer sublinear synaptic integration and
    a gradient of short-term plasticity. Neuron. 73(6), 1159–1172.
  mla: Abrahamsson, Therese, et al. “Thin Dendrites of Cerebellar Interneurons Confer
    Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity.” <i>Neuron</i>,
    vol. 73, no. 6, Elsevier, 2012, pp. 1159–72, doi:<a href="https://doi.org/10.1016/j.neuron.2012.01.027">10.1016/j.neuron.2012.01.027</a>.
  short: T. Abrahamsson, L. Cathala, K. Matsui, R. Shigemoto, D. Digregorio, Neuron
    73 (2012) 1159–1172.
date_created: 2018-12-11T11:57:52Z
date_published: 2012-03-22T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '22'
doi: 10.1016/j.neuron.2012.01.027
extern: 1
intvolume: '        73'
issue: '6'
month: '03'
page: 1159 - 1172
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '4427'
quality_controlled: 0
status: public
title: Thin dendrites of cerebellar interneurons confer sublinear synaptic integration
  and a gradient of short-term plasticity
type: journal_article
volume: 73
year: '2012'
...
---
_id: '2475'
abstract:
- lang: eng
  text: 'Background: One of the best-characterized causative factors of Alzheimer''s
    disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high
    risk of epileptic seizures accompanied by aberrant neuronal excitability, which
    in itself enhances Aβ generation. However, the molecular linkage between epileptic
    seizures and Aβ generation in AD remains unclear. Results: X11 and X11-like (X11L)
    gene knockout mice suffered from epileptic seizures, along with a malfunction
    of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Genetic
    ablation of HCN1 in mice and HCN1 channel blockage in cultured Neuro2a (N2a) cells
    enhanced Aβ generation. Interestingly, HCN1 levels dramatically decreased in the
    temporal lobe of cynomolgus monkeys (Macaca fascicularis) during aging and were
    significantly diminished in the temporal lobe of sporadic AD patients. Conclusion:
    Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in
    the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution
    along with epilepsy. Moreover, the reduction in HCN1 levels in aged primates may
    contribute to augmented Aβ generation. Taken together, HCN1 is proposed to play
    an important role in the molecular linkage between epileptic seizures and Aβ generation,
    and in the aggravation of sporadic AD.'
author:
- first_name: Yuhki
  full_name: Saito, Yuhki
  last_name: Saito
- first_name: Tsuyoshi
  full_name: Inoue, Tsuyoshi
  last_name: Inoue
- first_name: Gang
  full_name: Zhu, Gang
  last_name: Zhu
- first_name: Naoki
  full_name: Kimura, Naoki
  last_name: Kimura
- first_name: Motohiro
  full_name: Okada, Motohiro
  last_name: Okada
- first_name: Masaki
  full_name: Nishimura, Masaki
  last_name: Nishimura
- first_name: Shigeo
  full_name: Murayama, Shigeo
  last_name: Murayama
- first_name: Sunao
  full_name: Kaneko, Sunao
  last_name: Kaneko
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Keiji
  full_name: Imoto, Keiji
  last_name: Imoto
- first_name: Toshiharu
  full_name: Suzuki, Toshiharu
  last_name: Suzuki
citation:
  ama: 'Saito Y, Inoue T, Zhu G, et al. Hyperpolarization-activated cyclic nucleotide
    gated channels: A potential molecular link between epileptic seizures and Aβ generation
    in Alzheimer’s disease. <i>Molecular Neurodegeneration</i>. 2012;7(1). doi:<a
    href="https://doi.org/10.1186/1750-1326-7-50">10.1186/1750-1326-7-50</a>'
  apa: 'Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., … Suzuki,
    T. (2012). Hyperpolarization-activated cyclic nucleotide gated channels: A potential
    molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease.
    <i>Molecular Neurodegeneration</i>. BioMed Central. <a href="https://doi.org/10.1186/1750-1326-7-50">https://doi.org/10.1186/1750-1326-7-50</a>'
  chicago: 'Saito, Yuhki, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada,
    Masaki Nishimura, Shigeo Murayama, et al. “Hyperpolarization-Activated Cyclic
    Nucleotide Gated Channels: A Potential Molecular Link between Epileptic Seizures
    and Aβ Generation in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>.
    BioMed Central, 2012. <a href="https://doi.org/10.1186/1750-1326-7-50">https://doi.org/10.1186/1750-1326-7-50</a>.'
  ieee: 'Y. Saito <i>et al.</i>, “Hyperpolarization-activated cyclic nucleotide gated
    channels: A potential molecular link between epileptic seizures and Aβ generation
    in Alzheimer’s disease,” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1. BioMed
    Central, 2012.'
  ista: 'Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, Murayama S, Kaneko
    S, Shigemoto R, Imoto K, Suzuki T. 2012. Hyperpolarization-activated cyclic nucleotide
    gated channels: A potential molecular link between epileptic seizures and Aβ generation
    in Alzheimer’s disease. Molecular Neurodegeneration. 7(1).'
  mla: 'Saito, Yuhki, et al. “Hyperpolarization-Activated Cyclic Nucleotide Gated
    Channels: A Potential Molecular Link between Epileptic Seizures and Aβ Generation
    in Alzheimer’s Disease.” <i>Molecular Neurodegeneration</i>, vol. 7, no. 1, BioMed
    Central, 2012, doi:<a href="https://doi.org/10.1186/1750-1326-7-50">10.1186/1750-1326-7-50</a>.'
  short: Y. Saito, T. Inoue, G. Zhu, N. Kimura, M. Okada, M. Nishimura, S. Murayama,
    S. Kaneko, R. Shigemoto, K. Imoto, T. Suzuki, Molecular Neurodegeneration 7 (2012).
date_created: 2018-12-11T11:57:53Z
date_published: 2012-10-03T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '03'
doi: 10.1186/1750-1326-7-50
extern: 1
intvolume: '         7'
issue: '1'
month: '10'
publication: Molecular Neurodegeneration
publication_status: published
publisher: BioMed Central
publist_id: '4426'
quality_controlled: 0
status: public
title: 'Hyperpolarization-activated cyclic nucleotide gated channels: A potential
  molecular link between epileptic seizures and Aβ generation in Alzheimer''s disease'
type: journal_article
volume: 7
year: '2012'
...
---
_id: '2476'
abstract:
- lang: eng
  text: Recently developed pharmacogenetic and optogenetic approaches, with their
    own advantages and disadvantages, have become indispensable tools in modern neuroscience.
    Here, we employed a previously described knock-in mouse line (GABA ARγ2 77Ilox)
    in which the γ2 subunit of the GABA A receptor (GABA AR) was mutated to become
    zolpidem insensitive (γ2 77I) and used viral vectors to swap γ2 77I with wild-type,
    zolpidem-sensitive γ2 subunits (γ2 77F). The verification of unaltered density
    and subcellular distribution of the virally introduced γ2 subunits requires their
    selective labelling. For this we generated six N- and six C-terminal-tagged γ2
    subunits, with which cortical cultures of GABA ARγ2 -/- mice were transduced using
    lentiviruses. We found that the N-terminal AU1 tag resulted in excellent immunodetection
    and unimpaired synaptic localization. Unaltered kinetic properties of the AU1-tagged
    γ2 ( AU1γ2 77F) channels were demonstrated with whole-cell patch-clamp recordings
    of spontaneous IPSCs from cultured cells. Next, we carried out stereotaxic injections
    of lenti- and adeno-associated viruses containing Cre-recombinase and the AU1γ2
    77F subunit (Cre-2A- AU1γ2 77F) into the neocortex of GABA ARγ2 77Ilox mice. Light
    microscopic immunofluorescence and electron microscopic freeze-fracture replica
    immunogold labelling demonstrated the efficient immunodetection of the AU1 tag
    and the normal enrichment of the AU1γ2 77F subunits in perisomatic GABAergic synapses.
    In line with this, miniature and action potential-evoked IPSCs whole-cell recorded
    from transduced cells had unaltered amplitudes, kinetics and restored zolpidem
    sensitivity. Our results obtained with a wide range of structural and functional
    verification methods reveal unaltered subcellular distributions and functional
    properties of γ2 77I and AU1γ2 77F GABA ARs in cortical pyramidal cells. This
    transgenic-viral pharmacogenetic approach has the advantage that it does not require
    any extrinsic protein that might endow some unforeseen alterations of the genetically
    modified cells. In addition, this virus-based approach opens up the possibility
    of modifying multiple cell types in distinct brain regions and performing alternative
    recombination-based intersectional genetic manipulations.
author:
- first_name: Máté
  full_name: Sümegi, Máté
  last_name: Sümegi
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
- first_name: Andrea
  full_name: Lörincz, Andrea
  last_name: Lörincz
- first_name: Mark
  full_name: Eyre, Mark D
  last_name: Eyre
- first_name: Zoltán
  full_name: Nusser, Zoltán
  last_name: Nusser
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Sümegi M, Fukazawa Y, Matsui K, et al. Virus-mediated swapping of zolpidem-insensitive
    with zolpidem-sensitive GABA A receptors in cortical pyramidal cells. <i>Journal
    of Physiology</i>. 2012;590(7):1517-1534. doi:<a href="https://doi.org/10.1113/jphysiol.2012.227538">10.1113/jphysiol.2012.227538</a>
  apa: Sümegi, M., Fukazawa, Y., Matsui, K., Lörincz, A., Eyre, M., Nusser, Z., &#38;
    Shigemoto, R. (2012). Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive
    GABA A receptors in cortical pyramidal cells. <i>Journal of Physiology</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1113/jphysiol.2012.227538">https://doi.org/10.1113/jphysiol.2012.227538</a>
  chicago: Sümegi, Máté, Yugo Fukazawa, Ko Matsui, Andrea Lörincz, Mark Eyre, Zoltán
    Nusser, and Ryuichi Shigemoto. “Virus-Mediated Swapping of Zolpidem-Insensitive
    with Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal
    of Physiology</i>. Wiley-Blackwell, 2012. <a href="https://doi.org/10.1113/jphysiol.2012.227538">https://doi.org/10.1113/jphysiol.2012.227538</a>.
  ieee: M. Sümegi <i>et al.</i>, “Virus-mediated swapping of zolpidem-insensitive
    with zolpidem-sensitive GABA A receptors in cortical pyramidal cells,” <i>Journal
    of Physiology</i>, vol. 590, no. 7. Wiley-Blackwell, pp. 1517–1534, 2012.
  ista: Sümegi M, Fukazawa Y, Matsui K, Lörincz A, Eyre M, Nusser Z, Shigemoto R.
    2012. Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive
    GABA A receptors in cortical pyramidal cells. Journal of Physiology. 590(7), 1517–1534.
  mla: Sümegi, Máté, et al. “Virus-Mediated Swapping of Zolpidem-Insensitive with
    Zolpidem-Sensitive GABA A Receptors in Cortical Pyramidal Cells.” <i>Journal of
    Physiology</i>, vol. 590, no. 7, Wiley-Blackwell, 2012, pp. 1517–34, doi:<a href="https://doi.org/10.1113/jphysiol.2012.227538">10.1113/jphysiol.2012.227538</a>.
  short: M. Sümegi, Y. Fukazawa, K. Matsui, A. Lörincz, M. Eyre, Z. Nusser, R. Shigemoto,
    Journal of Physiology 590 (2012) 1517–1534.
date_created: 2018-12-11T11:57:53Z
date_published: 2012-04-07T00:00:00Z
date_updated: 2021-01-12T06:57:43Z
day: '07'
doi: 10.1113/jphysiol.2012.227538
extern: 1
intvolume: '       590'
issue: '7'
month: '04'
page: 1517 - 1534
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4425'
quality_controlled: 0
status: public
title: Virus-mediated swapping of zolpidem-insensitive with zolpidem-sensitive GABA
  A receptors in cortical pyramidal cells
type: journal_article
volume: 590
year: '2012'
...
---
_id: '2477'
abstract:
- lang: eng
  text: Dynamic activity of glia has repeatedly been demonstrated, but if such activity
    is independent from neuronal activity, glia would not have any role in the information
    processing in the brain or in the generation of animal behavior. Evidence for
    neurons communicating with glia is solid, but the signaling pathway leading back
    from glial-to-neuronal activity was often difficult to study. Here, we introduced
    a transgenic mouse line in which channelrhodopsin-2, a light-gated cation channel,
    was expressed in astrocytes. Selective photostimulation of these astrocytes in
    vivo triggered neuronal activation. Using slice preparations, we show that glial
    photostimulation leads to release of glutamate, which was sufficient to activate
    AMPA receptors on Purkinje cells and to induce long-term depression of parallel
    fiber-to-Purkinje cell synapses through activation of metabotropic glutamate receptors.
    In contrast to neuronal synaptic vesicular release, glial activation likely causes
    preferential activation of extrasynaptic receptors that appose glial membrane.
    Finally, we show that neuronal activation by glial stimulation can lead to perturbation
    of cerebellar modulated motor behavior. These findings demonstrate that glia can
    modulate the tone of neuronal activity and behavior. This animal model is expected
    to be a potentially powerful approach to study the role of glia in brain function.
author:
- first_name: Takuya
  full_name: Sasaki, Takuya
  last_name: Sasaki
- first_name: Kaoru
  full_name: Beppu, Kaoru
  last_name: Beppu
- first_name: Kenji
  full_name: Tanaka, Kenji F
  last_name: Tanaka
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
citation:
  ama: Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. Application
    of an optogenetic byway for perturbing neuronal activity via glial photostimulation.
    <i>PNAS</i>. 2012;109(50):20720-20725. doi:<a href="https://doi.org/10.1073/pnas.1213458109">10.1073/pnas.1213458109</a>
  apa: Sasaki, T., Beppu, K., Tanaka, K., Fukazawa, Y., Shigemoto, R., &#38; Matsui,
    K. (2012). Application of an optogenetic byway for perturbing neuronal activity
    via glial photostimulation. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1213458109">https://doi.org/10.1073/pnas.1213458109</a>
  chicago: Sasaki, Takuya, Kaoru Beppu, Kenji Tanaka, Yugo Fukazawa, Ryuichi Shigemoto,
    and Ko Matsui. “Application of an Optogenetic Byway for Perturbing Neuronal Activity
    via Glial Photostimulation.” <i>PNAS</i>. National Academy of Sciences, 2012.
    <a href="https://doi.org/10.1073/pnas.1213458109">https://doi.org/10.1073/pnas.1213458109</a>.
  ieee: T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, and K. Matsui,
    “Application of an optogenetic byway for perturbing neuronal activity via glial
    photostimulation,” <i>PNAS</i>, vol. 109, no. 50. National Academy of Sciences,
    pp. 20720–20725, 2012.
  ista: Sasaki T, Beppu K, Tanaka K, Fukazawa Y, Shigemoto R, Matsui K. 2012. Application
    of an optogenetic byway for perturbing neuronal activity via glial photostimulation.
    PNAS. 109(50), 20720–20725.
  mla: Sasaki, Takuya, et al. “Application of an Optogenetic Byway for Perturbing
    Neuronal Activity via Glial Photostimulation.” <i>PNAS</i>, vol. 109, no. 50,
    National Academy of Sciences, 2012, pp. 20720–25, doi:<a href="https://doi.org/10.1073/pnas.1213458109">10.1073/pnas.1213458109</a>.
  short: T. Sasaki, K. Beppu, K. Tanaka, Y. Fukazawa, R. Shigemoto, K. Matsui, PNAS
    109 (2012) 20720–20725.
date_created: 2018-12-11T11:57:54Z
date_published: 2012-12-11T00:00:00Z
date_updated: 2021-01-12T06:57:43Z
day: '11'
doi: 10.1073/pnas.1213458109
extern: 1
intvolume: '       109'
issue: '50'
month: '12'
page: 20720 - 20725
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '4424'
quality_controlled: 0
status: public
title: Application of an optogenetic byway for perturbing neuronal activity via glial
  photostimulation
type: journal_article
volume: 109
year: '2012'
...
---
_id: '2514'
abstract:
- lang: eng
  text: Visual information must be relayed through the lateral geniculate nucleus
    before it reaches the visual cortex. However, not all spikes created in the retina
    lead to postsynaptic spikes and properties of the retinogeniculate synapse contribute
    to this filtering. To understand the mechanisms underlying this filtering process,
    we conducted electrophysiology to assess the properties of signal transmission
    in the Long-Evans rat. We also performed SDS-digested freeze-fracture replica
    labeling to quantify the receptor and transporter distribution, as well as EM
    reconstruction to describe the 3D structure. To analyze the impact of transmitter
    diffusion on the activity of the receptors, simulations were integrated. We identified
    that a large contributor to the filtering is the marked paired-pulse depression
    at this synapse, which was intensified by the morphological characteristics of
    the contacts. The broad presynaptic and postsynaptic contact area restricts transmitter
    diffusion two dimensionally. Additionally, the presence of multiple closely arranged
    release sites invites intersynaptic spillover, which causes desensitization of
    AMPA receptors. The presence of AMPA receptors that slowly recover from desensitization
    along with the high presynaptic release probability and multivesicular release
    at each synapse also contribute to the depression. These features contrast with
    many other synapses where spatiotemporal spread of transmitter is limited by rapid
    transmitter clearance allowing synapses to operate more independently. We propose
    that the micrometer-order structure can ultimately affect the visual information
    processing.
author:
- first_name: Timotheus
  full_name: Budisantoso, Timotheus
  last_name: Budisantoso
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
- first_name: Naomi
  full_name: Kamasawa, Naomi
  last_name: Kamasawa
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. Mechanisms underlying
    signal filtering at a multisynapse contact. <i>Journal of Neuroscience</i>. 2012;32(7):2357-2376.
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.5243-11.2012">10.1523/JNEUROSCI.5243-11.2012</a>
  apa: Budisantoso, T., Matsui, K., Kamasawa, N., Fukazawa, Y., &#38; Shigemoto, R.
    (2012). Mechanisms underlying signal filtering at a multisynapse contact. <i>Journal
    of Neuroscience</i>. Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.5243-11.2012">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>
  chicago: Budisantoso, Timotheus, Ko Matsui, Naomi Kamasawa, Yugo Fukazawa, and Ryuichi
    Shigemoto. “Mechanisms Underlying Signal Filtering at a Multisynapse Contact.”
    <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href="https://doi.org/10.1523/JNEUROSCI.5243-11.2012">https://doi.org/10.1523/JNEUROSCI.5243-11.2012</a>.
  ieee: T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, and R. Shigemoto, “Mechanisms
    underlying signal filtering at a multisynapse contact,” <i>Journal of Neuroscience</i>,
    vol. 32, no. 7. Society for Neuroscience, pp. 2357–2376, 2012.
  ista: Budisantoso T, Matsui K, Kamasawa N, Fukazawa Y, Shigemoto R. 2012. Mechanisms
    underlying signal filtering at a multisynapse contact. Journal of Neuroscience.
    32(7), 2357–2376.
  mla: Budisantoso, Timotheus, et al. “Mechanisms Underlying Signal Filtering at a
    Multisynapse Contact.” <i>Journal of Neuroscience</i>, vol. 32, no. 7, Society
    for Neuroscience, 2012, pp. 2357–76, doi:<a href="https://doi.org/10.1523/JNEUROSCI.5243-11.2012">10.1523/JNEUROSCI.5243-11.2012</a>.
  short: T. Budisantoso, K. Matsui, N. Kamasawa, Y. Fukazawa, R. Shigemoto, Journal
    of Neuroscience 32 (2012) 2357–2376.
date_created: 2018-12-11T11:58:07Z
date_published: 2012-02-15T00:00:00Z
date_updated: 2021-01-12T06:57:57Z
day: '15'
doi: 10.1523/JNEUROSCI.5243-11.2012
extern: 1
intvolume: '        32'
issue: '7'
month: '02'
page: 2357 - 2376
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4387'
quality_controlled: 0
status: public
title: Mechanisms underlying signal filtering at a multisynapse contact
type: journal_article
volume: 32
year: '2012'
...
---
_id: '2515'
abstract:
- lang: eng
  text: We investigated the temporal and spatial expression of SK2 in the developing
    mouse hippocampus using molecular and biochemical techniques, quantitative immunogold
    electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed
    in the developing and adult hippocampus. Western blotting and immunohistochemistry
    showed that SK2 protein increased with age. This was accompanied by a shift in
    subcellular localization. Early in development (P5), SK2 was predominantly localized
    to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost
    exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic
    density (PSD) also increased during development. In the adult, SK2 expression
    on the spine plasma membrane showed a proximal-to-distal gradient. Consistent
    with this redistribution and gradient of SK2, the selective SK channel blocker
    apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1
    pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs
    was not different between synapses in proximal or distal stratum radiatum or stratum
    lacunosum-moleculare in adult. These results show a developmental increase and
    gradient in SK2-containing channel surface expression that underlie their influence
    on neurotransmission, and that may contribute to increased memory acquisition
    during early development.
author:
- first_name: Carmen
  full_name: Ballesteros-Merino, Carmen
  last_name: Ballesteros Merino
- first_name: Michael
  full_name: Lin, Michael
  last_name: Lin
- first_name: Wendy
  full_name: Wu, Wendy W
  last_name: Wu
- first_name: Clotilde
  full_name: Ferrándiz-Huertas, Clotilde
  last_name: Ferrándiz Huertas
- first_name: María
  full_name: Cabañero, María José
  last_name: Cabañero
- first_name: Masahiko
  full_name: Watanabe, Masahiko
  last_name: Watanabe
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: James
  full_name: Maylie, James G
  last_name: Maylie
- first_name: John
  full_name: Adelman, John P
  last_name: Adelman
- first_name: Rafael
  full_name: Luján, Rafael
  last_name: Luján
citation:
  ama: Ballesteros Merino C, Lin M, Wu W, et al.  Developmental profile of SK2 channel
    expression and function in CA1 neurons. <i>Hippocampus</i>. 2012;22(6):1467-1480.
    doi:<a href="https://doi.org/10.1002/hipo.20986">10.1002/hipo.20986</a>
  apa: Ballesteros Merino, C., Lin, M., Wu, W., Ferrándiz Huertas, C., Cabañero, M.,
    Watanabe, M., … Luján, R. (2012).  Developmental profile of SK2 channel expression
    and function in CA1 neurons. <i>Hippocampus</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/hipo.20986">https://doi.org/10.1002/hipo.20986</a>
  chicago: Ballesteros Merino, Carmen, Michael Lin, Wendy Wu, Clotilde Ferrándiz Huertas,
    María Cabañero, Masahiko Watanabe, Yugo Fukazawa, et al. “ Developmental Profile
    of SK2 Channel Expression and Function in CA1 Neurons.” <i>Hippocampus</i>. Wiley-Blackwell,
    2012. <a href="https://doi.org/10.1002/hipo.20986">https://doi.org/10.1002/hipo.20986</a>.
  ieee: C. Ballesteros Merino <i>et al.</i>, “ Developmental profile of SK2 channel
    expression and function in CA1 neurons,” <i>Hippocampus</i>, vol. 22, no. 6. Wiley-Blackwell,
    pp. 1467–1480, 2012.
  ista: Ballesteros Merino C, Lin M, Wu W, Ferrándiz Huertas C, Cabañero M, Watanabe
    M, Fukazawa Y, Shigemoto R, Maylie J, Adelman J, Luján R. 2012.  Developmental
    profile of SK2 channel expression and function in CA1 neurons. Hippocampus. 22(6),
    1467–1480.
  mla: Ballesteros Merino, Carmen, et al. “ Developmental Profile of SK2 Channel Expression
    and Function in CA1 Neurons.” <i>Hippocampus</i>, vol. 22, no. 6, Wiley-Blackwell,
    2012, pp. 1467–80, doi:<a href="https://doi.org/10.1002/hipo.20986">10.1002/hipo.20986</a>.
  short: C. Ballesteros Merino, M. Lin, W. Wu, C. Ferrándiz Huertas, M. Cabañero,
    M. Watanabe, Y. Fukazawa, R. Shigemoto, J. Maylie, J. Adelman, R. Luján, Hippocampus
    22 (2012) 1467–1480.
date_created: 2018-12-11T11:58:07Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T06:57:57Z
day: '01'
doi: 10.1002/hipo.20986
extern: 1
intvolume: '        22'
issue: '6'
month: '06'
page: 1467 - 1480
publication: Hippocampus
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4386'
quality_controlled: 0
status: public
title: ' Developmental profile of SK2 channel expression and function in CA1 neurons'
type: journal_article
volume: 22
year: '2012'
...
---
_id: '2687'
abstract:
- lang: eng
  text: Left-right asymmetry of human brain function has been known for a century,
    although much of molecular and cellular basis of brain laterality remains to be
    elusive. Recent studies suggest that hippocampal CA3-CA1 excitatory synapses are
    asymmetrically arranged, however, the functional implication of the asymmetrical
    circuitry has not been studied at the behavioral level. In order to address the
    left-right asymmetry of hippocampal function in behaving mice, we analyzed the
    performance of &quot;split-brain&quot; mice in the Barnes maze. The &quot;split-brain&quot;
    mice received ventral hippocampal commissure and corpus callosum transection in
    addition to deprivation of visual input from one eye. In such mice, the hippocampus
    in the side of visual deprivation receives sensory-driven input. Better spatial
    task performance was achieved by the mice which were forced to use the right hippocampus
    than those which were forced to use the left hippocampus. In two-choice spatial
    maze, forced usage of left hippocampus resulted in a comparable performance to
    the right counterpart, suggesting that both hippocampal hemispheres are capable
    of conducting spatial learning. Therefore, the results obtained from the Barnes
    maze suggest that the usage of the right hippocampus improves the accuracy of
    spatial memory. Performance of non-spatial yet hippocampus-dependent tasks (e.g.
    fear conditioning) was not influenced by the laterality of the hippocampus.
author:
- first_name: Yoshiaki
  full_name: Shinohara, Yoshiaki
  last_name: Shinohara
- first_name: Aki
  full_name: Hosoya, Aki
  last_name: Hosoya
- first_name: Nobuyuki
  full_name: Yamasaki, Nobuyuki
  last_name: Yamasaki
- first_name: Hassan
  full_name: Ahmed, Hassan
  last_name: Ahmed
- first_name: Satoko
  full_name: Hattori, Satoko
  last_name: Hattori
- first_name: Megumi
  full_name: Eguchi, Megumi
  last_name: Eguchi
- first_name: Shun
  full_name: Yamaguchi, Shun
  last_name: Yamaguchi
- first_name: Tsuyoshi
  full_name: Miyakawa, Tsuyoshi
  last_name: Miyakawa
- first_name: Hajime
  full_name: Hirase, Hajime
  last_name: Hirase
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Shinohara Y, Hosoya A, Yamasaki N, et al. Right-hemispheric dominance of spatial
    memory in split-brain mice. <i>Hippocampus</i>. 2012;22(2):117-121. doi:<a href="https://doi.org/10.1002/hipo.20886">10.1002/hipo.20886</a>
  apa: Shinohara, Y., Hosoya, A., Yamasaki, N., Ahmed, H., Hattori, S., Eguchi, M.,
    … Shigemoto, R. (2012). Right-hemispheric dominance of spatial memory in split-brain
    mice. <i>Hippocampus</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/hipo.20886">https://doi.org/10.1002/hipo.20886</a>
  chicago: Shinohara, Yoshiaki, Aki Hosoya, Nobuyuki Yamasaki, Hassan Ahmed, Satoko
    Hattori, Megumi Eguchi, Shun Yamaguchi, Tsuyoshi Miyakawa, Hajime Hirase, and
    Ryuichi Shigemoto. “Right-Hemispheric Dominance of Spatial Memory in Split-Brain
    Mice.” <i>Hippocampus</i>. Wiley-Blackwell, 2012. <a href="https://doi.org/10.1002/hipo.20886">https://doi.org/10.1002/hipo.20886</a>.
  ieee: Y. Shinohara <i>et al.</i>, “Right-hemispheric dominance of spatial memory
    in split-brain mice,” <i>Hippocampus</i>, vol. 22, no. 2. Wiley-Blackwell, pp.
    117–121, 2012.
  ista: Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi
    S, Miyakawa T, Hirase H, Shigemoto R. 2012. Right-hemispheric dominance of spatial
    memory in split-brain mice. Hippocampus. 22(2), 117–121.
  mla: Shinohara, Yoshiaki, et al. “Right-Hemispheric Dominance of Spatial Memory
    in Split-Brain Mice.” <i>Hippocampus</i>, vol. 22, no. 2, Wiley-Blackwell, 2012,
    pp. 117–21, doi:<a href="https://doi.org/10.1002/hipo.20886">10.1002/hipo.20886</a>.
  short: Y. Shinohara, A. Hosoya, N. Yamasaki, H. Ahmed, S. Hattori, M. Eguchi, S.
    Yamaguchi, T. Miyakawa, H. Hirase, R. Shigemoto, Hippocampus 22 (2012) 117–121.
date_created: 2018-12-11T11:59:04Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:03Z
day: '01'
doi: 10.1002/hipo.20886
extern: 1
intvolume: '        22'
issue: '2'
month: '01'
page: 117 - 121
publication: Hippocampus
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4210'
quality_controlled: 0
status: public
title: Right-hemispheric dominance of spatial memory in split-brain mice
type: journal_article
volume: 22
year: '2012'
...
---
_id: '2688'
abstract:
- lang: eng
  text: To gain insights into structure-function relationship of excitatory synapses,
    we revisit our quantitative analysis of synaptic AMPAR by highly sensitive freeze-fracture
    replica labeling in eight different connections. All of these connections showed
    linear correlation between synapse size and AMPAR number indicating a common intra-synapse-type
    relationship in CNS synapses. On the contrary, inter-synapse-type relationship
    is unexpected indicating no correlation between averages of synapse size and AMPAR
    number. Interestingly, connections with large average synapse size and low AMPAR
    density showed high variability of AMPAR number and mosaic distribution within
    the postsynaptic membrane. We propose an idea that these connections may quickly
    exhibit synaptic plasticity by modifying AMPAR density/number whereas those with
    high AMPAR density change their efficacy by modifying synapse size.
author:
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
citation:
  ama: Fukazawa Y, Shigemoto R. Intra-synapse-type and inter-synapse-type relationships
    between synaptic size and AMPAR expression. <i>Current Opinion in Neurobiology</i>.
    2012;22(3):446-452. doi:<a href="https://doi.org/10.1016/j.conb.2012.01.006">10.1016/j.conb.2012.01.006</a>
  apa: Fukazawa, Y., &#38; Shigemoto, R. (2012). Intra-synapse-type and inter-synapse-type
    relationships between synaptic size and AMPAR expression. <i>Current Opinion in
    Neurobiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.conb.2012.01.006">https://doi.org/10.1016/j.conb.2012.01.006</a>
  chicago: Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type
    Relationships between Synaptic Size and AMPAR Expression.” <i>Current Opinion
    in Neurobiology</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.conb.2012.01.006">https://doi.org/10.1016/j.conb.2012.01.006</a>.
  ieee: Y. Fukazawa and R. Shigemoto, “Intra-synapse-type and inter-synapse-type relationships
    between synaptic size and AMPAR expression,” <i>Current Opinion in Neurobiology</i>,
    vol. 22, no. 3. Elsevier, pp. 446–452, 2012.
  ista: Fukazawa Y, Shigemoto R. 2012. Intra-synapse-type and inter-synapse-type relationships
    between synaptic size and AMPAR expression. Current Opinion in Neurobiology. 22(3),
    446–452.
  mla: Fukazawa, Yugo, and Ryuichi Shigemoto. “Intra-Synapse-Type and Inter-Synapse-Type
    Relationships between Synaptic Size and AMPAR Expression.” <i>Current Opinion
    in Neurobiology</i>, vol. 22, no. 3, Elsevier, 2012, pp. 446–52, doi:<a href="https://doi.org/10.1016/j.conb.2012.01.006">10.1016/j.conb.2012.01.006</a>.
  short: Y. Fukazawa, R. Shigemoto, Current Opinion in Neurobiology 22 (2012) 446–452.
date_created: 2018-12-11T11:59:04Z
date_published: 2012-06-01T00:00:00Z
date_updated: 2021-01-12T06:59:03Z
day: '01'
doi: 10.1016/j.conb.2012.01.006
extern: 1
intvolume: '        22'
issue: '3'
month: '06'
page: 446 - 452
publication: Current Opinion in Neurobiology
publication_status: published
publisher: Elsevier
publist_id: '4209'
quality_controlled: 0
status: public
title: Intra-synapse-type and inter-synapse-type relationships between synaptic size
  and AMPAR expression
type: journal_article
volume: 22
year: '2012'
...
---
_id: '2689'
abstract:
- lang: eng
  text: R-type calcium channels (RTCCs) are well known for their role in synaptic
    plasticity, but little is known about their subcellular distribution across various
    neuronal compartments. Using subtype-specific antibodies, we characterized the
    regional and subcellular localization of Ca v2.3 in mice and rats at both light
    and electron microscopic levels. Ca v2.3 immunogold particles were found to be
    predominantly presynaptic in the interpeduncular nucleus, but postsynaptic in
    other brain regions. Serial section analysis of electron microscopic images from
    the hippocampal CA1 revealed a higher density of immunogold particles in the dendritic
    shaft plasma membrane compared with the pyramidal cell somata. However, the labeling
    densities were not significantly different among the apical, oblique, or basal
    dendrites. Immunogold particles were also observed over the plasma membrane of
    dendritic spines, including both synaptic and extrasynaptic sites. Individual
    spine heads contained &lt;20 immunogold particles, with an average density of
    ~260 immunoparticles per μm 3 spine head volume, in accordance with the density
    of RTCCs estimated using calcium imaging (Sabatini and Svoboda, 2000). The Ca
    v2.3 density was variable among similar-sized spine heads and did not correlate
    with the density in the parent dendrite, implying that spines are individual calcium
    compartments operating autonomously from their parent dendrites.
author:
- first_name: Laxmi
  full_name: Parajuli, Laxmi K
  last_name: Parajuli
- first_name: Chikako
  full_name: Nakajima, Chikako
  last_name: Nakajima
- first_name: Ákos
  full_name: Kulik, Ákos
  last_name: Kulik
- first_name: Ko
  full_name: Matsui, Ko
  last_name: Matsui
- first_name: Toni
  full_name: Schneider, Toni
  last_name: Schneider
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
citation:
  ama: Parajuli L, Nakajima C, Kulik Á, et al. Quantitative regional and ultra structural
    localization of the Ca v2 3 subunit of R type calcium channel in mouse brain.
    <i>Journal of Neuroscience</i>. 2012;32(39):13555-13567. doi:<a href="https://doi.org/10.1523/JNEUROSCI.1142-12.2012">10.1523/JNEUROSCI.1142-12.2012</a>
  apa: Parajuli, L., Nakajima, C., Kulik, Á., Matsui, K., Schneider, T., Shigemoto,
    R., &#38; Fukazawa, Y. (2012). Quantitative regional and ultra structural localization
    of the Ca v2 3 subunit of R type calcium channel in mouse brain. <i>Journal of
    Neuroscience</i>. Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.1142-12.2012">https://doi.org/10.1523/JNEUROSCI.1142-12.2012</a>
  chicago: Parajuli, Laxmi, Chikako Nakajima, Ákos Kulik, Ko Matsui, Toni Schneider,
    Ryuichi Shigemoto, and Yugo Fukazawa. “Quantitative Regional and Ultra Structural
    Localization of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.”
    <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href="https://doi.org/10.1523/JNEUROSCI.1142-12.2012">https://doi.org/10.1523/JNEUROSCI.1142-12.2012</a>.
  ieee: L. Parajuli <i>et al.</i>, “Quantitative regional and ultra structural localization
    of the Ca v2 3 subunit of R type calcium channel in mouse brain,” <i>Journal of
    Neuroscience</i>, vol. 32, no. 39. Society for Neuroscience, pp. 13555–13567,
    2012.
  ista: Parajuli L, Nakajima C, Kulik Á, Matsui K, Schneider T, Shigemoto R, Fukazawa
    Y. 2012. Quantitative regional and ultra structural localization of the Ca v2
    3 subunit of R type calcium channel in mouse brain. Journal of Neuroscience. 32(39),
    13555–13567.
  mla: Parajuli, Laxmi, et al. “Quantitative Regional and Ultra Structural Localization
    of the Ca v2 3 Subunit of R Type Calcium Channel in Mouse Brain.” <i>Journal of
    Neuroscience</i>, vol. 32, no. 39, Society for Neuroscience, 2012, pp. 13555–67,
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.1142-12.2012">10.1523/JNEUROSCI.1142-12.2012</a>.
  short: L. Parajuli, C. Nakajima, Á. Kulik, K. Matsui, T. Schneider, R. Shigemoto,
    Y. Fukazawa, Journal of Neuroscience 32 (2012) 13555–13567.
date_created: 2018-12-11T11:59:05Z
date_published: 2012-09-26T00:00:00Z
date_updated: 2021-01-12T06:59:04Z
day: '26'
doi: 10.1523/JNEUROSCI.1142-12.2012
extern: 1
intvolume: '        32'
issue: '39'
month: '09'
page: 13555 - 13567
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4208'
quality_controlled: 0
status: public
title: Quantitative regional and ultra structural localization of the Ca v2 3 subunit
  of R type calcium channel in mouse brain
type: journal_article
volume: 32
year: '2012'
...
---
_id: '2696'
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
citation:
  ama: Erdös L. Universality for random matrices and log-gases. <i>ArXiv</i>. 2012.
  apa: Erdös, L. (2012). Universality for random matrices and log-gases. <i>ArXiv</i>.
    ArXiv.
  chicago: Erdös, László. “Universality for Random Matrices and Log-Gases.” <i>ArXiv</i>.
    ArXiv, 2012.
  ieee: L. Erdös, “Universality for random matrices and log-gases,” <i>ArXiv</i>.
    ArXiv, 2012.
  ista: Erdös L. 2012. Universality for random matrices and log-gases. ArXiv, .
  mla: Erdös, László. “Universality for Random Matrices and Log-Gases.” <i>ArXiv</i>,
    ArXiv, 2012.
  short: L. Erdös, ArXiv (2012).
date_created: 2018-12-11T11:59:07Z
date_published: 2012-12-04T00:00:00Z
date_updated: 2021-01-12T06:59:06Z
day: '04'
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1212.0839
month: '12'
oa: 1
publication: ArXiv
publication_status: published
publisher: ArXiv
publist_id: '4201'
quality_controlled: 0
status: public
title: Universality for random matrices and log-gases
type: preprint
year: '2012'
...
---
_id: '2700'
alternative_title:
- Quantum Theory from Small to Large Scales
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
citation:
  ama: 'Erdös L. Lecture notes on quantum Brownian motion. In: Vol 95. Oxford University
    Press; 2012:3-98.'
  apa: Erdös, L. (2012). Lecture notes on quantum Brownian motion (Vol. 95, pp. 3–98).
    Presented at the Les Houches Summer School 2010, Oxford University Press.
  chicago: Erdös, László. “Lecture Notes on Quantum Brownian Motion,” 95:3–98. Oxford
    University Press, 2012.
  ieee: L. Erdös, “Lecture notes on quantum Brownian motion,” presented at the Les
    Houches Summer School 2010, 2012, vol. 95, pp. 3–98.
  ista: Erdös L. 2012. Lecture notes on quantum Brownian motion. Les Houches Summer
    School 2010, Quantum Theory from Small to Large Scales, vol. 95, 3–98.
  mla: Erdös, László. <i>Lecture Notes on Quantum Brownian Motion</i>. Vol. 95, Oxford
    University Press, 2012, pp. 3–98.
  short: L. Erdös, in:, Oxford University Press, 2012, pp. 3–98.
conference:
  name: Les Houches Summer School 2010
date_created: 2018-12-11T11:59:08Z
date_published: 2012-05-24T00:00:00Z
date_updated: 2021-01-12T06:59:08Z
day: '24'
extern: 1
intvolume: '        95'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1009.0843
month: '05'
oa: 1
page: 3 - 98
publication_status: published
publisher: Oxford University Press
publist_id: '4196'
quality_controlled: 0
status: public
title: Lecture notes on quantum Brownian motion
type: conference
volume: 95
year: '2012'
...
---
_id: '2715'
abstract:
- lang: eng
  text: 'We consider Markov decision processes (MDPs) with specifications given as
    Büchi (liveness) objectives. We consider the problem of computing the set of almost-sure
    winning vertices from where the objective can be ensured with probability 1. We
    study for the first time the average case complexity of the classical algorithm
    for computing the set of almost-sure winning vertices for MDPs with Büchi objectives.
    Our contributions are as follows: First, we show that for MDPs with constant out-degree
    the expected number of iterations is at most logarithmic and the average case
    running time is linear (as compared to the worst case linear number of iterations
    and quadratic time complexity). Second, for the average case analysis over all
    MDPs we show that the expected number of iterations is constant and the average
    case running time is linear (again as compared to the worst case linear number
    of iterations and quadratic time complexity). Finally we also show that given
    that all MDPs are equally likely, the probability that the classical algorithm
    requires more than constant number of iterations is exponentially small.'
alternative_title:
- LIPIcs
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Manas
  full_name: Joglekar, Manas
  last_name: Joglekar
- first_name: Nisarg
  full_name: Shah, Nisarg
  last_name: Shah
citation:
  ama: 'Chatterjee K, Joglekar M, Shah N. Average case analysis of the classical algorithm
    for Markov decision processes with Büchi objectives. In: Vol 18. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik; 2012:461-473. doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461">10.4230/LIPIcs.FSTTCS.2012.461</a>'
  apa: 'Chatterjee, K., Joglekar, M., &#38; Shah, N. (2012). Average case analysis
    of the classical algorithm for Markov decision processes with Büchi objectives
    (Vol. 18, pp. 461–473). Presented at the FSTTCS: Foundations of Software Technology
    and Theoretical Computer Science, Hyderabad, India: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461">https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461</a>'
  chicago: Chatterjee, Krishnendu, Manas Joglekar, and Nisarg Shah. “Average Case
    Analysis of the Classical Algorithm for Markov Decision Processes with Büchi Objectives,”
    18:461–73. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2012. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461">https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461</a>.
  ieee: 'K. Chatterjee, M. Joglekar, and N. Shah, “Average case analysis of the classical
    algorithm for Markov decision processes with Büchi objectives,” presented at the
    FSTTCS: Foundations of Software Technology and Theoretical Computer Science, Hyderabad,
    India, 2012, vol. 18, pp. 461–473.'
  ista: 'Chatterjee K, Joglekar M, Shah N. 2012. Average case analysis of the classical
    algorithm for Markov decision processes with Büchi objectives. FSTTCS: Foundations
    of Software Technology and Theoretical Computer Science, LIPIcs, vol. 18, 461–473.'
  mla: Chatterjee, Krishnendu, et al. <i>Average Case Analysis of the Classical Algorithm
    for Markov Decision Processes with Büchi Objectives</i>. Vol. 18, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2012, pp. 461–73, doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2012.461">10.4230/LIPIcs.FSTTCS.2012.461</a>.
  short: K. Chatterjee, M. Joglekar, N. Shah, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2012, pp. 461–473.
conference:
  end_date: 2012-12-17
  location: Hyderabad, India
  name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
  start_date: 2012-12-15
date_created: 2018-12-11T11:59:13Z
date_published: 2012-12-10T00:00:00Z
date_updated: 2023-02-23T10:06:04Z
day: '10'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.FSTTCS.2012.461
ec_funded: 1
file:
- access_level: open_access
  checksum: d4d644ed1a885dbfc4fa1ef4c5724dab
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  date_updated: 2020-07-14T12:45:45Z
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file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: '        18'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 461 - 473
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '4180'
pubrep_id: '525'
quality_controlled: '1'
related_material:
  record:
  - id: '1598'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Average case analysis of the classical algorithm for Markov decision processes
  with Büchi objectives
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2012'
...
---
_id: '2767'
abstract:
- lang: eng
  text: 'Consider N × N Hermitian or symmetric random matrices H where the distribution
    of the (i, j) matrix element is given by a probability measure ν ij with a subexponential
    decay. Let σ ij 2 be the variance for the probability measure ν ij with the normalization
    property that Σ iσ i,j 2 = 1 for all j. Under essentially the only condition that
    c ≤ N σ ij 2 ≤ c -1 for some constant c &gt; 0, we prove that, in the limit N
    → ∞, the eigenvalue spacing statistics of H in the bulk of the spectrum coincide
    with those of the Gaussian unitary or orthogonal ensemble (GUE or GOE). We also
    show that for band matrices with bandwidth M the local semicircle law holds to
    the energy scale M -1. '
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Horng
  full_name: Yau, Horng-Tzer
  last_name: Yau
- first_name: Jun
  full_name: Yin, Jun
  last_name: Yin
citation:
  ama: Erdös L, Yau H, Yin J. Bulk universality for generalized Wigner matrices. <i>Probability
    Theory and Related Fields</i>. 2012;154(1-2):341-407. doi:<a href="https://doi.org/10.1007/s00440-011-0390-3">10.1007/s00440-011-0390-3</a>
  apa: Erdös, L., Yau, H., &#38; Yin, J. (2012). Bulk universality for generalized
    Wigner matrices. <i>Probability Theory and Related Fields</i>. Springer. <a href="https://doi.org/10.1007/s00440-011-0390-3">https://doi.org/10.1007/s00440-011-0390-3</a>
  chicago: Erdös, László, Horng Yau, and Jun Yin. “Bulk Universality for Generalized
    Wigner Matrices.” <i>Probability Theory and Related Fields</i>. Springer, 2012.
    <a href="https://doi.org/10.1007/s00440-011-0390-3">https://doi.org/10.1007/s00440-011-0390-3</a>.
  ieee: L. Erdös, H. Yau, and J. Yin, “Bulk universality for generalized Wigner matrices,”
    <i>Probability Theory and Related Fields</i>, vol. 154, no. 1–2. Springer, pp.
    341–407, 2012.
  ista: Erdös L, Yau H, Yin J. 2012. Bulk universality for generalized Wigner matrices.
    Probability Theory and Related Fields. 154(1–2), 341–407.
  mla: Erdös, László, et al. “Bulk Universality for Generalized Wigner Matrices.”
    <i>Probability Theory and Related Fields</i>, vol. 154, no. 1–2, Springer, 2012,
    pp. 341–407, doi:<a href="https://doi.org/10.1007/s00440-011-0390-3">10.1007/s00440-011-0390-3</a>.
  short: L. Erdös, H. Yau, J. Yin, Probability Theory and Related Fields 154 (2012)
    341–407.
date_created: 2018-12-11T11:59:29Z
date_published: 2012-10-01T00:00:00Z
date_updated: 2021-01-12T06:59:33Z
day: '01'
doi: 10.1007/s00440-011-0390-3
extern: 1
intvolume: '       154'
issue: 1-2
month: '10'
page: 341 - 407
publication: Probability Theory and Related Fields
publication_status: published
publisher: Springer
publist_id: '4123'
quality_controlled: 0
status: public
title: Bulk universality for generalized Wigner matrices
type: journal_article
volume: 154
year: '2012'
...
---
_id: '2768'
abstract:
- lang: eng
  text: We consider a two dimensional magnetic Schrödinger operator with a spatially
    stationary random magnetic field. We assume that the magnetic field has a positive
    lower bound and that it has Fourier modes on arbitrarily short scales. We prove
    the Wegner estimate at arbitrary energy, i. e. we show that the averaged density
    of states is finite throughout the whole spectrum. We also prove Anderson localization
    at the bottom of the spectrum.
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: David
  full_name: Hasler, David G
  last_name: Hasler
citation:
  ama: Erdös L, Hasler D. Wegner estimate and Anderson localization for random magnetic
    fields. <i>Communications in Mathematical Physics</i>. 2012;309(2):507-542. doi:<a
    href="https://doi.org/10.1007/s00220-011-1373-z">10.1007/s00220-011-1373-z</a>
  apa: Erdös, L., &#38; Hasler, D. (2012). Wegner estimate and Anderson localization
    for random magnetic fields. <i>Communications in Mathematical Physics</i>. Springer.
    <a href="https://doi.org/10.1007/s00220-011-1373-z">https://doi.org/10.1007/s00220-011-1373-z</a>
  chicago: Erdös, László, and David Hasler. “Wegner Estimate and Anderson Localization
    for Random Magnetic Fields.” <i>Communications in Mathematical Physics</i>. Springer,
    2012. <a href="https://doi.org/10.1007/s00220-011-1373-z">https://doi.org/10.1007/s00220-011-1373-z</a>.
  ieee: L. Erdös and D. Hasler, “Wegner estimate and Anderson localization for random
    magnetic fields,” <i>Communications in Mathematical Physics</i>, vol. 309, no.
    2. Springer, pp. 507–542, 2012.
  ista: Erdös L, Hasler D. 2012. Wegner estimate and Anderson localization for random
    magnetic fields. Communications in Mathematical Physics. 309(2), 507–542.
  mla: Erdös, László, and David Hasler. “Wegner Estimate and Anderson Localization
    for Random Magnetic Fields.” <i>Communications in Mathematical Physics</i>, vol.
    309, no. 2, Springer, 2012, pp. 507–42, doi:<a href="https://doi.org/10.1007/s00220-011-1373-z">10.1007/s00220-011-1373-z</a>.
  short: L. Erdös, D. Hasler, Communications in Mathematical Physics 309 (2012) 507–542.
date_created: 2018-12-11T11:59:30Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:34Z
day: '01'
doi: 10.1007/s00220-011-1373-z
extern: 1
intvolume: '       309'
issue: '2'
month: '01'
page: 507 - 542
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4122'
quality_controlled: 0
status: public
title: Wegner estimate and Anderson localization for random magnetic fields
type: journal_article
volume: 309
year: '2012'
...
---
_id: '2769'
abstract:
- lang: eng
  text: We present a generalization of the method of the local relaxation flow to
    establish the universality of local spectral statistics of a broad class of large
    random matrices. We show that the local distribution of the eigenvalues coincides
    with the local statistics of the corresponding Gaussian ensemble provided the
    distribution of the individual matrix element is smooth and the eigenvalues {X
    J} N j=1 are close to their classical location {y j} N j=1 determined by the limiting
    density of eigenvalues. Under the scaling where the typical distance between neighboring
    eigenvalues is of order 1/N, the necessary apriori estimate on the location of
    eigenvalues requires only to know that E|x j - γ j| 2 ≤ N-1-ε on average. This
    information can be obtained by well established methods for various matrix ensembles.
    We demonstrate the method by proving local spectral universality for sample covariance
    matrices.
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Benjamin
  full_name: Schlein, Benjamin
  last_name: Schlein
- first_name: Horng
  full_name: Yau, Horng-Tzer
  last_name: Yau
- first_name: Jun
  full_name: Yin, Jun
  last_name: Yin
citation:
  ama: Erdös L, Schlein B, Yau H, Yin J. The local relaxation flow approach to universality
    of the local statistics for random matrices. <i>Annales de l’institut Henri Poincare
    (B) Probability and Statistics</i>. 2012;48(1):1-46. doi:<a href="https://doi.org/10.1214/10-AIHP388">10.1214/10-AIHP388</a>
  apa: Erdös, L., Schlein, B., Yau, H., &#38; Yin, J. (2012). The local relaxation
    flow approach to universality of the local statistics for random matrices. <i>Annales
    de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of
    Mathematical Statistics. <a href="https://doi.org/10.1214/10-AIHP388">https://doi.org/10.1214/10-AIHP388</a>
  chicago: Erdös, László, Benjamin Schlein, Horng Yau, and Jun Yin. “The Local Relaxation
    Flow Approach to Universality of the Local Statistics for Random Matrices.” <i>Annales
    de l’institut Henri Poincare (B) Probability and Statistics</i>. Institute of
    Mathematical Statistics, 2012. <a href="https://doi.org/10.1214/10-AIHP388">https://doi.org/10.1214/10-AIHP388</a>.
  ieee: L. Erdös, B. Schlein, H. Yau, and J. Yin, “The local relaxation flow approach
    to universality of the local statistics for random matrices,” <i>Annales de l’institut
    Henri Poincare (B) Probability and Statistics</i>, vol. 48, no. 1. Institute of
    Mathematical Statistics, pp. 1–46, 2012.
  ista: Erdös L, Schlein B, Yau H, Yin J. 2012. The local relaxation flow approach
    to universality of the local statistics for random matrices. Annales de l’institut
    Henri Poincare (B) Probability and Statistics. 48(1), 1–46.
  mla: Erdös, László, et al. “The Local Relaxation Flow Approach to Universality of
    the Local Statistics for Random Matrices.” <i>Annales de l’institut Henri Poincare
    (B) Probability and Statistics</i>, vol. 48, no. 1, Institute of Mathematical
    Statistics, 2012, pp. 1–46, doi:<a href="https://doi.org/10.1214/10-AIHP388">10.1214/10-AIHP388</a>.
  short: L. Erdös, B. Schlein, H. Yau, J. Yin, Annales de l’institut Henri Poincare
    (B) Probability and Statistics 48 (2012) 1–46.
date_created: 2018-12-11T11:59:30Z
date_published: 2012-02-01T00:00:00Z
date_updated: 2021-01-12T06:59:34Z
day: '01'
doi: 10.1214/10-AIHP388
extern: 1
intvolume: '        48'
issue: '1'
month: '02'
page: 1 - 46
publication: Annales de l'institut Henri Poincare (B) Probability and Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '4121'
quality_controlled: 0
status: public
title: The local relaxation flow approach to universality of the local statistics
  for random matrices
type: journal_article
volume: 48
year: '2012'
...
---
_id: '2770'
abstract:
- lang: eng
  text: 'Consider N×N Hermitian or symmetric random matrices H with independent entries,
    where the distribution of the (i,j) matrix element is given by the probability
    measure vij with zero expectation and with variance σ ιj 2. We assume that the
    variances satisfy the normalization condition Σiσij2=1 for all j and that there
    is a positive constant c such that c≤Nσ ιj 2 ιc -1. We further assume that the
    probability distributions νij have a uniform subexponential decay. We prove that
    the Stieltjes transform of the empirical eigenvalue distribution of H is given
    by the Wigner semicircle law uniformly up to the edges of the spectrum with an
    error of order (Nη) -1 where η is the imaginary part of the spectral parameter
    in the Stieltjes transform. There are three corollaries to this strong local semicircle
    law: (1) Rigidity of eigenvalues: If γj=γj,N denotes the classical location of
    the j-th eigenvalue under the semicircle law ordered in increasing order, then
    the j-th eigenvalue λj is close to γj in the sense that for some positive constants
    C, c P{double-struck}(∃j:|λ j-γ j|≥(logN) CloglogN[min(j,N-j+1)] -1/3N -2/3)≤
    C exp[-(logN) cloglogN] for N large enough. (2) The proof of Dyson''s conjecture
    (Dyson, 1962 [15]) which states that the time scale of the Dyson Brownian motion
    to reach local equilibrium is of order N -1 up to logarithmic corrections. (3)
    The edge universality holds in the sense that the probability distributions of
    the largest (and the smallest) eigenvalues of two generalized Wigner ensembles
    are the same in the large N limit provided that the second moments of the two
    ensembles are identical.'
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Horng
  full_name: Yau, Horng-Tzer
  last_name: Yau
- first_name: Jun
  full_name: Yin, Jun
  last_name: Yin
citation:
  ama: Erdös L, Yau H, Yin J. Rigidity of eigenvalues of generalized Wigner matrices.
    <i>Advances in Mathematics</i>. 2012;229(3):1435-1515. doi:<a href="https://doi.org/10.1016/j.aim.2011.12.010">10.1016/j.aim.2011.12.010</a>
  apa: Erdös, L., Yau, H., &#38; Yin, J. (2012). Rigidity of eigenvalues of generalized
    Wigner matrices. <i>Advances in Mathematics</i>. Academic Press. <a href="https://doi.org/10.1016/j.aim.2011.12.010">https://doi.org/10.1016/j.aim.2011.12.010</a>
  chicago: Erdös, László, Horng Yau, and Jun Yin. “Rigidity of Eigenvalues of Generalized
    Wigner Matrices.” <i>Advances in Mathematics</i>. Academic Press, 2012. <a href="https://doi.org/10.1016/j.aim.2011.12.010">https://doi.org/10.1016/j.aim.2011.12.010</a>.
  ieee: L. Erdös, H. Yau, and J. Yin, “Rigidity of eigenvalues of generalized Wigner
    matrices,” <i>Advances in Mathematics</i>, vol. 229, no. 3. Academic Press, pp.
    1435–1515, 2012.
  ista: Erdös L, Yau H, Yin J. 2012. Rigidity of eigenvalues of generalized Wigner
    matrices. Advances in Mathematics. 229(3), 1435–1515.
  mla: Erdös, László, et al. “Rigidity of Eigenvalues of Generalized Wigner Matrices.”
    <i>Advances in Mathematics</i>, vol. 229, no. 3, Academic Press, 2012, pp. 1435–515,
    doi:<a href="https://doi.org/10.1016/j.aim.2011.12.010">10.1016/j.aim.2011.12.010</a>.
  short: L. Erdös, H. Yau, J. Yin, Advances in Mathematics 229 (2012) 1435–1515.
date_created: 2018-12-11T11:59:30Z
date_published: 2012-02-15T00:00:00Z
date_updated: 2021-01-12T06:59:35Z
day: '15'
doi: 10.1016/j.aim.2011.12.010
extern: 1
intvolume: '       229'
issue: '3'
month: '02'
page: 1435 - 1515
publication: Advances in Mathematics
publication_status: published
publisher: Academic Press
publist_id: '4120'
quality_controlled: 0
status: public
title: Rigidity of eigenvalues of generalized Wigner matrices
type: journal_article
volume: 229
year: '2012'
...
---
_id: '2771'
abstract:
- lang: eng
  text: We consider a magnetic Schrödinger operator in two dimensions. The magnetic
    field is given as the sum of a large and constant magnetic field and a random
    magnetic field. Moreover, we allow for an additional deterministic potential as
    well as a magnetic field which are both periodic. We show that the spectrum of
    this operator is contained in broadened bands around the Landau levels and that
    the edges of these bands consist of pure point spectrum with exponentially decaying
    eigenfunctions. The proof is based on a recent Wegner estimate obtained in Erdos
    and Hasler (Commun. Math. Phys., preprint, arXiv:1012.5185) and a multiscale analysis.
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: David
  full_name: Hasler, David G
  last_name: Hasler
citation:
  ama: Erdös L, Hasler D. Anderson localization at band edges for random magnetic
    fields. <i>Journal of Statistical Physics</i>. 2012;146(5):900-923. doi:<a href="https://doi.org/10.1007/s10955-012-0445-6">10.1007/s10955-012-0445-6</a>
  apa: Erdös, L., &#38; Hasler, D. (2012). Anderson localization at band edges for
    random magnetic fields. <i>Journal of Statistical Physics</i>. Springer. <a href="https://doi.org/10.1007/s10955-012-0445-6">https://doi.org/10.1007/s10955-012-0445-6</a>
  chicago: Erdös, László, and David Hasler. “Anderson Localization at Band Edges for
    Random Magnetic Fields.” <i>Journal of Statistical Physics</i>. Springer, 2012.
    <a href="https://doi.org/10.1007/s10955-012-0445-6">https://doi.org/10.1007/s10955-012-0445-6</a>.
  ieee: L. Erdös and D. Hasler, “Anderson localization at band edges for random magnetic
    fields,” <i>Journal of Statistical Physics</i>, vol. 146, no. 5. Springer, pp.
    900–923, 2012.
  ista: Erdös L, Hasler D. 2012. Anderson localization at band edges for random magnetic
    fields. Journal of Statistical Physics. 146(5), 900–923.
  mla: Erdös, László, and David Hasler. “Anderson Localization at Band Edges for Random
    Magnetic Fields.” <i>Journal of Statistical Physics</i>, vol. 146, no. 5, Springer,
    2012, pp. 900–23, doi:<a href="https://doi.org/10.1007/s10955-012-0445-6">10.1007/s10955-012-0445-6</a>.
  short: L. Erdös, D. Hasler, Journal of Statistical Physics 146 (2012) 900–923.
date_created: 2018-12-11T11:59:31Z
date_published: 2012-03-01T00:00:00Z
date_updated: 2021-01-12T06:59:35Z
day: '01'
doi: 10.1007/s10955-012-0445-6
extern: 1
intvolume: '       146'
issue: '5'
month: '03'
page: 900 - 923
publication: Journal of Statistical Physics
publication_status: published
publisher: Springer
publist_id: '4119'
quality_controlled: 0
status: public
title: Anderson localization at band edges for random magnetic fields
type: journal_article
volume: 146
year: '2012'
...
---
_id: '2772'
abstract:
- lang: eng
  text: We consider the semiclassical asymptotics of the sum of negative eigenvalues
    of the three-dimensional Pauli operator with an external potential and a self-generated
    magnetic field B. We also add the field energy β ∫ B 2 and we minimize over all
    magnetic fields. The parameter β effectively determines the strength of the field.
    We consider the weak field regime with βh 2 ≥ const &gt; 0, where h is the semiclassical
    parameter. For smooth potentials we prove that the semiclassical asymptotics of
    the total energy is given by the non-magnetic Weyl term to leading order with
    an error bound that is smaller by a factor h 1+e{open}, i. e. the subleading term
    vanishes. However for potentials with a Coulomb singularity, the subleading term
    does not vanish due to the non-semiclassical effect of the singularity. Combined
    with a multiscale technique, this refined estimate is used in the companion paper
    (Erdo{double acute}s et al. in Scott correction for large molecules with a self-generated
    magnetic field, Preprint, 2011) to prove the second order Scott correction to
    the ground state energy of large atoms and molecules.
author:
- first_name: László
  full_name: László Erdös
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Søren
  full_name: Fournais, Søren
  last_name: Fournais
- first_name: Jan
  full_name: Solovej, Jan P
  last_name: Solovej
citation:
  ama: Erdös L, Fournais S, Solovej J. Second order semiclassics with self generated
    magnetic fields. <i>Annales Henri Poincare</i>. 2012;13(4):671-730. doi:<a href="https://doi.org/10.1007/s00023-011-0150-z">10.1007/s00023-011-0150-z</a>
  apa: Erdös, L., Fournais, S., &#38; Solovej, J. (2012). Second order semiclassics
    with self generated magnetic fields. <i>Annales Henri Poincare</i>. Birkhäuser.
    <a href="https://doi.org/10.1007/s00023-011-0150-z">https://doi.org/10.1007/s00023-011-0150-z</a>
  chicago: Erdös, László, Søren Fournais, and Jan Solovej. “Second Order Semiclassics
    with Self Generated Magnetic Fields.” <i>Annales Henri Poincare</i>. Birkhäuser,
    2012. <a href="https://doi.org/10.1007/s00023-011-0150-z">https://doi.org/10.1007/s00023-011-0150-z</a>.
  ieee: L. Erdös, S. Fournais, and J. Solovej, “Second order semiclassics with self
    generated magnetic fields,” <i>Annales Henri Poincare</i>, vol. 13, no. 4. Birkhäuser,
    pp. 671–730, 2012.
  ista: Erdös L, Fournais S, Solovej J. 2012. Second order semiclassics with self
    generated magnetic fields. Annales Henri Poincare. 13(4), 671–730.
  mla: Erdös, László, et al. “Second Order Semiclassics with Self Generated Magnetic
    Fields.” <i>Annales Henri Poincare</i>, vol. 13, no. 4, Birkhäuser, 2012, pp.
    671–730, doi:<a href="https://doi.org/10.1007/s00023-011-0150-z">10.1007/s00023-011-0150-z</a>.
  short: L. Erdös, S. Fournais, J. Solovej, Annales Henri Poincare 13 (2012) 671–730.
date_created: 2018-12-11T11:59:31Z
date_published: 2012-05-01T00:00:00Z
date_updated: 2021-01-12T06:59:36Z
day: '01'
doi: 10.1007/s00023-011-0150-z
extern: 1
intvolume: '        13'
issue: '4'
month: '05'
page: 671 - 730
publication: Annales Henri Poincare
publication_status: published
publisher: Birkhäuser
publist_id: '4118'
quality_controlled: 0
status: public
title: Second order semiclassics with self generated magnetic fields
type: journal_article
volume: 13
year: '2012'
...
