---
_id: '12640'
abstract:
- lang: eng
  text: Greater Himalayan glaciers are retreating and losing mass at rates comparable
    to glaciers in other regions of the world1,2,3,4,5. Assessments of future changes
    and their associated hydrological impacts are scarce, oversimplify glacier dynamics
    or include a limited number of climate models6,7,8,9. Here, we use results from
    the latest ensemble of climate models in combination with a high-resolution glacio-hydrological
    model to assess the hydrological impact of climate change on two climatically
    contrasting watersheds in the Greater Himalaya, the Baltoro and Langtang watersheds
    that drain into the Indus and Ganges rivers, respectively. We show that the largest
    uncertainty in future runoff is a result of variations in projected precipitation
    between climate models. In both watersheds, strong, but highly variable, increases
    in future runoff are projected and, despite the different characteristics of the
    watersheds, their responses are surprisingly similar. In both cases, glaciers
    will recede but net glacier melt runoff is on a rising limb at least until 2050.
    In combination with a positive change in precipitation, water availability during
    this century is not likely to decline. We conclude that river basins that depend
    on monsoon rains and glacier melt will continue to sustain the increasing water
    demands expected in these areas10.
article_processing_charge: No
article_type: letter_note
author:
- first_name: W. W.
  full_name: Immerzeel, W. W.
  last_name: Immerzeel
- first_name: Francesca
  full_name: Pellicciotti, Francesca
  id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
  last_name: Pellicciotti
- first_name: M. F. P.
  full_name: Bierkens, M. F. P.
  last_name: Bierkens
citation:
  ama: Immerzeel WW, Pellicciotti F, Bierkens MFP. Rising river flows throughout the
    twenty-first century in two Himalayan glacierized watersheds. <i>Nature Geoscience</i>.
    2013;6(9):742-745. doi:<a href="https://doi.org/10.1038/ngeo1896">10.1038/ngeo1896</a>
  apa: Immerzeel, W. W., Pellicciotti, F., &#38; Bierkens, M. F. P. (2013). Rising
    river flows throughout the twenty-first century in two Himalayan glacierized watersheds.
    <i>Nature Geoscience</i>. Springer Nature. <a href="https://doi.org/10.1038/ngeo1896">https://doi.org/10.1038/ngeo1896</a>
  chicago: Immerzeel, W. W., Francesca Pellicciotti, and M. F. P. Bierkens. “Rising
    River Flows throughout the Twenty-First Century in Two Himalayan Glacierized Watersheds.”
    <i>Nature Geoscience</i>. Springer Nature, 2013. <a href="https://doi.org/10.1038/ngeo1896">https://doi.org/10.1038/ngeo1896</a>.
  ieee: W. W. Immerzeel, F. Pellicciotti, and M. F. P. Bierkens, “Rising river flows
    throughout the twenty-first century in two Himalayan glacierized watersheds,”
    <i>Nature Geoscience</i>, vol. 6, no. 9. Springer Nature, pp. 742–745, 2013.
  ista: Immerzeel WW, Pellicciotti F, Bierkens MFP. 2013. Rising river flows throughout
    the twenty-first century in two Himalayan glacierized watersheds. Nature Geoscience.
    6(9), 742–745.
  mla: Immerzeel, W. W., et al. “Rising River Flows throughout the Twenty-First Century
    in Two Himalayan Glacierized Watersheds.” <i>Nature Geoscience</i>, vol. 6, no.
    9, Springer Nature, 2013, pp. 742–45, doi:<a href="https://doi.org/10.1038/ngeo1896">10.1038/ngeo1896</a>.
  short: W.W. Immerzeel, F. Pellicciotti, M.F.P. Bierkens, Nature Geoscience 6 (2013)
    742–745.
date_created: 2023-02-20T08:17:17Z
date_published: 2013-09-13T00:00:00Z
date_updated: 2023-02-21T10:46:37Z
day: '13'
doi: 10.1038/ngeo1896
extern: '1'
intvolume: '         6'
issue: '9'
keyword:
- General Earth and Planetary Sciences
language:
- iso: eng
month: '09'
oa_version: None
page: 742-745
publication: Nature Geoscience
publication_identifier:
  eissn:
  - 1752-0908
  issn:
  - 1752-0894
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rising river flows throughout the twenty-first century in two Himalayan glacierized
  watersheds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2013'
...
---
_id: '12641'
abstract:
- lang: eng
  text: We investigate the sensitivity of a distributed enhanced temperature-index
    (ETI) melt model, in order to understand which parameters have the largest influence
    on model outputs and thus need to be accurately known. We use melt and meteorological
    data from two Alpine glaciers and one glacier in the Andes of Chile. Sensitivity
    analysis is conducted in a systematic way in terms of parameters and the different
    conditions (day, night, clear-sky, overcast), melt seasons and glaciers examined.
    The sensitivity of total melt to changes in individual parameters is calculated
    using a local method around the optimal value of the parameters. We verify that
    the parameters are optimal at the distributed scale and assess the model uncertainty
    induced by uncertainty in the parameters using a Monte Carlo technique. Model
    sensitivity to parameters is consistent across melt seasons, glaciers, different
    conditions and the daily statistics examined. The parameters to which the model
    is most sensitive are the shortwave-radiation factor, the temperature lapse rate
    for extrapolation of air temperature, the albedo parameters, the temperature threshold
    and the cloud transmittance factor parameters. A parameter uncertainty of 5% results
    in a model uncertainty of 5.6% of mean melt on Haut Glacier d’Arolla, Switzerland.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
  full_name: Heynen, Martin
  last_name: Heynen
- first_name: Francesca
  full_name: Pellicciotti, Francesca
  id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
  last_name: Pellicciotti
- first_name: Marco
  full_name: Carenzo, Marco
  last_name: Carenzo
citation:
  ama: Heynen M, Pellicciotti F, Carenzo M. Parameter sensitivity of a distributed
    enhanced temperature-index melt model. <i>Annals of Glaciology</i>. 2013;54(63):311-321.
    doi:<a href="https://doi.org/10.3189/2013aog63a537">10.3189/2013aog63a537</a>
  apa: Heynen, M., Pellicciotti, F., &#38; Carenzo, M. (2013). Parameter sensitivity
    of a distributed enhanced temperature-index melt model. <i>Annals of Glaciology</i>.
    International Glaciological Society. <a href="https://doi.org/10.3189/2013aog63a537">https://doi.org/10.3189/2013aog63a537</a>
  chicago: Heynen, Martin, Francesca Pellicciotti, and Marco Carenzo. “Parameter Sensitivity
    of a Distributed Enhanced Temperature-Index Melt Model.” <i>Annals of Glaciology</i>.
    International Glaciological Society, 2013. <a href="https://doi.org/10.3189/2013aog63a537">https://doi.org/10.3189/2013aog63a537</a>.
  ieee: M. Heynen, F. Pellicciotti, and M. Carenzo, “Parameter sensitivity of a distributed
    enhanced temperature-index melt model,” <i>Annals of Glaciology</i>, vol. 54,
    no. 63. International Glaciological Society, pp. 311–321, 2013.
  ista: Heynen M, Pellicciotti F, Carenzo M. 2013. Parameter sensitivity of a distributed
    enhanced temperature-index melt model. Annals of Glaciology. 54(63), 311–321.
  mla: Heynen, Martin, et al. “Parameter Sensitivity of a Distributed Enhanced Temperature-Index
    Melt Model.” <i>Annals of Glaciology</i>, vol. 54, no. 63, International Glaciological
    Society, 2013, pp. 311–21, doi:<a href="https://doi.org/10.3189/2013aog63a537">10.3189/2013aog63a537</a>.
  short: M. Heynen, F. Pellicciotti, M. Carenzo, Annals of Glaciology 54 (2013) 311–321.
date_created: 2023-02-20T08:17:21Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-02-21T10:43:42Z
day: '01'
doi: 10.3189/2013aog63a537
extern: '1'
intvolume: '        54'
issue: '63'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.3189/2013aog63a537
month: '08'
oa: 1
oa_version: Published Version
page: 311-321
publication: Annals of Glaciology
publication_identifier:
  eissn:
  - 1727-5644
  issn:
  - 0260-3055
publication_status: published
publisher: International Glaciological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Parameter sensitivity of a distributed enhanced temperature-index melt model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2013'
...
---
_id: '12642'
abstract:
- lang: eng
  text: Near-surface air temperature, typically measured at a height of 2 m, is the
    most important control on the energy exchange and the melt rate at a snow or ice
    surface. It is distributed in a simplistic manner in most glacier melt models
    by using constant linear lapse rates, which poorly represent the actual spatial
    and temporal variability of air temperature. In this paper, we test a simple thermodynamic
    model proposed by Greuell and Böhm in 1998 as an alternative, using a new dataset
    of air temperature measurements from along the flowline of Haut Glacier d’Arolla,
    Switzerland. The unmodified model performs little better than assuming a constant
    linear lapse rate. When modified to allow the ratio of the boundary layer height
    to the bulk heat transfer coefficient to vary along the flowline, the model matches
    measured air temperatures better, and a further reduction of the root-mean-square
    error is obtained, although there is still considerable scope for improvement.
    The modified model is shown to perform best under conditions favourable to the
    development of katabatic winds – few clouds, positive ambient air temperature,
    limited influence of synoptic or valley winds and a long fetch – but its performance
    is poor under cloudy conditions.
article_processing_charge: No
article_type: original
author:
- first_name: Lene
  full_name: Petersen, Lene
  last_name: Petersen
- first_name: Francesca
  full_name: Pellicciotti, Francesca
  id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
  last_name: Pellicciotti
- first_name: Inge
  full_name: Juszak, Inge
  last_name: Juszak
- first_name: Marco
  full_name: Carenzo, Marco
  last_name: Carenzo
- first_name: Ben
  full_name: Brock, Ben
  last_name: Brock
citation:
  ama: 'Petersen L, Pellicciotti F, Juszak I, Carenzo M, Brock B. Suitability of a
    constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
    and Böhm model as an alternative. <i>Annals of Glaciology</i>. 2013;54(63):120-130.
    doi:<a href="https://doi.org/10.3189/2013aog63a477">10.3189/2013aog63a477</a>'
  apa: 'Petersen, L., Pellicciotti, F., Juszak, I., Carenzo, M., &#38; Brock, B. (2013).
    Suitability of a constant air temperature lapse rate over an Alpine glacier: Testing
    the Greuell and Böhm model as an alternative. <i>Annals of Glaciology</i>. International
    Glaciological Society. <a href="https://doi.org/10.3189/2013aog63a477">https://doi.org/10.3189/2013aog63a477</a>'
  chicago: 'Petersen, Lene, Francesca Pellicciotti, Inge Juszak, Marco Carenzo, and
    Ben Brock. “Suitability of a Constant Air Temperature Lapse Rate over an Alpine
    Glacier: Testing the Greuell and Böhm Model as an Alternative.” <i>Annals of Glaciology</i>.
    International Glaciological Society, 2013. <a href="https://doi.org/10.3189/2013aog63a477">https://doi.org/10.3189/2013aog63a477</a>.'
  ieee: 'L. Petersen, F. Pellicciotti, I. Juszak, M. Carenzo, and B. Brock, “Suitability
    of a constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
    and Böhm model as an alternative,” <i>Annals of Glaciology</i>, vol. 54, no. 63.
    International Glaciological Society, pp. 120–130, 2013.'
  ista: 'Petersen L, Pellicciotti F, Juszak I, Carenzo M, Brock B. 2013. Suitability
    of a constant air temperature lapse rate over an Alpine glacier: Testing the Greuell
    and Böhm model as an alternative. Annals of Glaciology. 54(63), 120–130.'
  mla: 'Petersen, Lene, et al. “Suitability of a Constant Air Temperature Lapse Rate
    over an Alpine Glacier: Testing the Greuell and Böhm Model as an Alternative.”
    <i>Annals of Glaciology</i>, vol. 54, no. 63, International Glaciological Society,
    2013, pp. 120–30, doi:<a href="https://doi.org/10.3189/2013aog63a477">10.3189/2013aog63a477</a>.'
  short: L. Petersen, F. Pellicciotti, I. Juszak, M. Carenzo, B. Brock, Annals of
    Glaciology 54 (2013) 120–130.
date_created: 2023-02-20T08:17:29Z
date_published: 2013-08-01T00:00:00Z
date_updated: 2023-02-21T10:18:24Z
day: '01'
doi: 10.3189/2013aog63a477
extern: '1'
intvolume: '        54'
issue: '63'
keyword:
- Earth-Surface Processes
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.3189/2013aog63a477
month: '08'
oa: 1
oa_version: Published Version
page: 120-130
publication: Annals of Glaciology
publication_identifier:
  eissn:
  - 1727-5644
  issn:
  - 0260-3055
publication_status: published
publisher: International Glaciological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Suitability of a constant air temperature lapse rate over an Alpine glacier:
  Testing the Greuell and Böhm model as an alternative'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2013'
...
---
_id: '12643'
abstract:
- lang: eng
  text: Parameterizations of incoming longwave radiation are increasingly receiving
    attention for both low and high elevation glacierized sites. In this paper, we
    test 13 clear-sky parameterizations combined with seven cloud corrections for
    all-sky atmospheric emissivity at one location on Haut Glacier d'Arolla. We also
    analyze the four seasons separately and conduct a cross-validation to test the
    parameters’ robustness. The best parameterization is the one by Dilley and O'Brien,
    B for clear-sky conditions combined with Unsworth and Monteith cloud correction.
    This model is also the most robust when tested in cross-validation. When validated
    at different sites in the southern Alps of Switzerland and north-western Italian
    Alps, all parameterizations show a substantial decrease in performance, except
    for one site, thus suggesting that it is important to recalibrate parameterizations
    of incoming longwave radiation for different locations. We argue that this is
    due to differences in the structure of the atmosphere at the sites. We also quantify
    the effect that the incoming longwave radiation parameterizations have on energy-balance
    melt modeling, and show that recalibration of model parameters is needed. Using
    parameters from other sites leads to a significant underestimation of melt and
    to an error that is larger than that associated with using different parameterizations.
    Once recalibrated, however, the parameters of most models seem to be stable over
    seasons and years at the location on Haut Glacier d'Arolla.
article_processing_charge: No
article_type: original
author:
- first_name: I.
  full_name: Juszak, I.
  last_name: Juszak
- first_name: Francesca
  full_name: Pellicciotti, Francesca
  id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
  last_name: Pellicciotti
citation:
  ama: 'Juszak I, Pellicciotti F. A comparison of parameterizations of incoming longwave
    radiation over melting glaciers: Model robustness and seasonal variability. <i>Journal
    of Geophysical Research: Atmospheres</i>. 2013;118(8):3066-3084. doi:<a href="https://doi.org/10.1002/jgrd.50277">10.1002/jgrd.50277</a>'
  apa: 'Juszak, I., &#38; Pellicciotti, F. (2013). A comparison of parameterizations
    of incoming longwave radiation over melting glaciers: Model robustness and seasonal
    variability. <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical
    Union. <a href="https://doi.org/10.1002/jgrd.50277">https://doi.org/10.1002/jgrd.50277</a>'
  chicago: 'Juszak, I., and Francesca Pellicciotti. “A Comparison of Parameterizations
    of Incoming Longwave Radiation over Melting Glaciers: Model Robustness and Seasonal
    Variability.” <i>Journal of Geophysical Research: Atmospheres</i>. American Geophysical
    Union, 2013. <a href="https://doi.org/10.1002/jgrd.50277">https://doi.org/10.1002/jgrd.50277</a>.'
  ieee: 'I. Juszak and F. Pellicciotti, “A comparison of parameterizations of incoming
    longwave radiation over melting glaciers: Model robustness and seasonal variability,”
    <i>Journal of Geophysical Research: Atmospheres</i>, vol. 118, no. 8. American
    Geophysical Union, pp. 3066–3084, 2013.'
  ista: 'Juszak I, Pellicciotti F. 2013. A comparison of parameterizations of incoming
    longwave radiation over melting glaciers: Model robustness and seasonal variability.
    Journal of Geophysical Research: Atmospheres. 118(8), 3066–3084.'
  mla: 'Juszak, I., and Francesca Pellicciotti. “A Comparison of Parameterizations
    of Incoming Longwave Radiation over Melting Glaciers: Model Robustness and Seasonal
    Variability.” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 118, no.
    8, American Geophysical Union, 2013, pp. 3066–84, doi:<a href="https://doi.org/10.1002/jgrd.50277">10.1002/jgrd.50277</a>.'
  short: 'I. Juszak, F. Pellicciotti, Journal of Geophysical Research: Atmospheres
    118 (2013) 3066–3084.'
date_created: 2023-02-20T08:17:34Z
date_published: 2013-04-27T00:00:00Z
date_updated: 2023-02-21T10:10:46Z
day: '27'
doi: 10.1002/jgrd.50277
extern: '1'
intvolume: '       118'
issue: '8'
keyword:
- Space and Planetary Science
- Earth and Planetary Sciences (miscellaneous)
- Atmospheric Science
- Geophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/jgrd.50277
month: '04'
oa: 1
oa_version: Published Version
page: 3066-3084
publication: 'Journal of Geophysical Research: Atmospheres'
publication_identifier:
  issn:
  - 2169-897X
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A comparison of parameterizations of incoming longwave radiation over melting
  glaciers: Model robustness and seasonal variability'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2013'
...
---
_id: '1304'
abstract:
- lang: eng
  text: When confronted with a large-field stimulus rotating around the vertical body
    axis, flies display a following behavior called &quot;optomotor response.&quot;
    As neural control elements, the large tangential horizontal system (HS) cells
    of the lobula plate have been prime candidates for long. Here, we applied optogenetic
    stimulation of HS cells to evaluate their behavioral role in Drosophila. To minimize
    interference of the optical activation of channelrhodopsin-2 with the visual perception
    of the flies, we used a bistable variant called ChR2-C128S. By applying pulses
    of blue and yellow light, we first demonstrate electrophysiologically that lobula
    plate tangential cells can be activated and deactivated repeatedly with no evident
    change in depolarization strength over trials. We next show that selective optogenetic
    activation of HS cells elicits robust yaw head movements and yaw turning responses
    in fixed and tethered flying flies, respectively.
acknowledgement: 'This work was supported by the Max Planck Society. '
author:
- first_name: Väinö
  full_name: Haikala, Väinö
  last_name: Haikala
- first_name: Maximilian A
  full_name: Maximilian Jösch
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
- first_name: Alexander
  full_name: Borst, Alexander
  last_name: Borst
- first_name: Alex
  full_name: Mauss, Alex S
  last_name: Mauss
citation:
  ama: Haikala V, Jösch MA, Borst A, Mauss A. Optogenetic control of fly optomotor
    responses. <i>Journal of Neuroscience</i>. 2013;33(34):13927-13934. doi:<a href="https://doi.org/10.1523/JNEUROSCI.0340-13.2013">10.1523/JNEUROSCI.0340-13.2013</a>
  apa: Haikala, V., Jösch, M. A., Borst, A., &#38; Mauss, A. (2013). Optogenetic control
    of fly optomotor responses. <i>Journal of Neuroscience</i>. Society for Neuroscience.
    <a href="https://doi.org/10.1523/JNEUROSCI.0340-13.2013">https://doi.org/10.1523/JNEUROSCI.0340-13.2013</a>
  chicago: Haikala, Väinö, Maximilian A Jösch, Alexander Borst, and Alex Mauss. “Optogenetic
    Control of Fly Optomotor Responses.” <i>Journal of Neuroscience</i>. Society for
    Neuroscience, 2013. <a href="https://doi.org/10.1523/JNEUROSCI.0340-13.2013">https://doi.org/10.1523/JNEUROSCI.0340-13.2013</a>.
  ieee: V. Haikala, M. A. Jösch, A. Borst, and A. Mauss, “Optogenetic control of fly
    optomotor responses,” <i>Journal of Neuroscience</i>, vol. 33, no. 34. Society
    for Neuroscience, pp. 13927–13934, 2013.
  ista: Haikala V, Jösch MA, Borst A, Mauss A. 2013. Optogenetic control of fly optomotor
    responses. Journal of Neuroscience. 33(34), 13927–13934.
  mla: Haikala, Väinö, et al. “Optogenetic Control of Fly Optomotor Responses.” <i>Journal
    of Neuroscience</i>, vol. 33, no. 34, Society for Neuroscience, 2013, pp. 13927–34,
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.0340-13.2013">10.1523/JNEUROSCI.0340-13.2013</a>.
  short: V. Haikala, M.A. Jösch, A. Borst, A. Mauss, Journal of Neuroscience 33 (2013)
    13927–13934.
date_created: 2018-12-11T11:51:16Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:45Z
day: '01'
doi: 10.1523/JNEUROSCI.0340-13.2013
extern: 1
intvolume: '        33'
issue: '34'
month: '01'
page: 13927 - 13934
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '5967'
quality_controlled: 0
status: public
title: Optogenetic control of fly optomotor responses
type: journal_article
volume: 33
year: '2013'
...
---
_id: '1305'
abstract:
- lang: eng
  text: In the fly Drosophila melanogaster, photoreceptor input to motion vision is
    split into two parallel pathways as represented by first-order interneurons L1
    and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways
    are functionally specialized remains controversial. One study (Eichner et al.,
    2011) proposed that the L1-pathway evaluates only sequences of brightness increments
    (ON-ON), while the L2-pathway processes exclusively brightness decrements (OFF-OFF).
    Another study (Clark et al., 2011) proposed that each of the two pathways evaluates
    both ON-ON and OFF-OFF sequences. To decide between these alternatives, we recorded
    from motionsensitive neurons in flies in which the output from either L1 or L2
    was genetically blocked. We found that blocking L1 abolishes ON-ON responses but
    leaves OFF-OFF responses intact. The opposite was true, when the output from L2
    was blocked. We conclude that the L1 and L2 pathways are functionally specialized
    to detect ON-ON and OFF-OFF sequences, respectively.
acknowledgement: This work was supported by the Max-Planck-Society and the SFB 870
  of the Deutsche Forschungsgemeinschaft.
author:
- first_name: Maximilian A
  full_name: Maximilian Jösch
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
- first_name: Franz
  full_name: Weber, Franz
  last_name: Weber
- first_name: Hubert
  full_name: Eichner, Hubert
  last_name: Eichner
- first_name: Alexander
  full_name: Borst, Alexander
  last_name: Borst
citation:
  ama: Jösch MA, Weber F, Eichner H, Borst A. Functional specialization of parallel
    motion detection circuits in the fly. <i>Journal of Neuroscience</i>. 2013;33(3):902-905.
    doi:<a href="https://doi.org/10.1523/JNEUROSCI.3374-12.2013">10.1523/JNEUROSCI.3374-12.2013</a>
  apa: Jösch, M. A., Weber, F., Eichner, H., &#38; Borst, A. (2013). Functional specialization
    of parallel motion detection circuits in the fly. <i>Journal of Neuroscience</i>.
    Society for Neuroscience. <a href="https://doi.org/10.1523/JNEUROSCI.3374-12.2013">https://doi.org/10.1523/JNEUROSCI.3374-12.2013</a>
  chicago: Jösch, Maximilian A, Franz Weber, Hubert Eichner, and Alexander Borst.
    “Functional Specialization of Parallel Motion Detection Circuits in the Fly.”
    <i>Journal of Neuroscience</i>. Society for Neuroscience, 2013. <a href="https://doi.org/10.1523/JNEUROSCI.3374-12.2013">https://doi.org/10.1523/JNEUROSCI.3374-12.2013</a>.
  ieee: M. A. Jösch, F. Weber, H. Eichner, and A. Borst, “Functional specialization
    of parallel motion detection circuits in the fly,” <i>Journal of Neuroscience</i>,
    vol. 33, no. 3. Society for Neuroscience, pp. 902–905, 2013.
  ista: Jösch MA, Weber F, Eichner H, Borst A. 2013. Functional specialization of
    parallel motion detection circuits in the fly. Journal of Neuroscience. 33(3),
    902–905.
  mla: Jösch, Maximilian A., et al. “Functional Specialization of Parallel Motion
    Detection Circuits in the Fly.” <i>Journal of Neuroscience</i>, vol. 33, no. 3,
    Society for Neuroscience, 2013, pp. 902–05, doi:<a href="https://doi.org/10.1523/JNEUROSCI.3374-12.2013">10.1523/JNEUROSCI.3374-12.2013</a>.
  short: M.A. Jösch, F. Weber, H. Eichner, A. Borst, Journal of Neuroscience 33 (2013)
    902–905.
date_created: 2018-12-11T11:51:16Z
date_published: 2013-01-16T00:00:00Z
date_updated: 2021-01-12T06:49:45Z
day: '16'
doi: 10.1523/JNEUROSCI.3374-12.2013
extern: 1
intvolume: '        33'
issue: '3'
month: '01'
page: 902 - 905
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '5968'
quality_controlled: 0
status: public
title: Functional specialization of parallel motion detection circuits in the fly
type: journal_article
volume: 33
year: '2013'
...
---
_id: '1307'
abstract:
- lang: eng
  text: We prove uniqueness of solutions of the DLSS equation in a class of sufficiently
    regular functions. The global weak solutions of the DLSS equation constructed
    by Jüngel and Matthes belong to this class of uniqueness. We also show uniqueness
    of solutions for the quantum drift-diffusion equation, which contains additional
    drift and second-order diffusion terms. The results hold in case of periodic or
    Dirichlet-Neumann boundary conditions. Our proof is based on a monotonicity property
    of the DLSS operator and sophisticated approximation arguments; we derive a PDE
    satisfied by the pointwise square root of the solution, which enables us to exploit
    the monotonicity property of the operator.
author:
- first_name: Julian L
  full_name: Julian Fischer
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
citation:
  ama: Fischer JL. Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn equation
    and quantum drift diffusion models. <i>Communications in Partial Differential
    Equations</i>. 2013;38(11):2004-2047. doi:<a href="https://doi.org/10.1080/03605302.2013.823548">10.1080/03605302.2013.823548</a>
  apa: Fischer, J. L. (2013). Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
    equation and quantum drift diffusion models. <i>Communications in Partial Differential
    Equations</i>. Taylor &#38; Francis. <a href="https://doi.org/10.1080/03605302.2013.823548">https://doi.org/10.1080/03605302.2013.823548</a>
  chicago: Fischer, Julian L. “Uniqueness of Solutions of the Derrida-Lebowitz-Speer-Spohn
    Equation and Quantum Drift Diffusion Models.” <i>Communications in Partial Differential
    Equations</i>. Taylor &#38; Francis, 2013. <a href="https://doi.org/10.1080/03605302.2013.823548">https://doi.org/10.1080/03605302.2013.823548</a>.
  ieee: J. L. Fischer, “Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
    equation and quantum drift diffusion models,” <i>Communications in Partial Differential
    Equations</i>, vol. 38, no. 11. Taylor &#38; Francis, pp. 2004–2047, 2013.
  ista: Fischer JL. 2013. Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn
    equation and quantum drift diffusion models. Communications in Partial Differential
    Equations. 38(11), 2004–2047.
  mla: Fischer, Julian L. “Uniqueness of Solutions of the Derrida-Lebowitz-Speer-Spohn
    Equation and Quantum Drift Diffusion Models.” <i>Communications in Partial Differential
    Equations</i>, vol. 38, no. 11, Taylor &#38; Francis, 2013, pp. 2004–47, doi:<a
    href="https://doi.org/10.1080/03605302.2013.823548">10.1080/03605302.2013.823548</a>.
  short: J.L. Fischer, Communications in Partial Differential Equations 38 (2013)
    2004–2047.
date_created: 2018-12-11T11:51:17Z
date_published: 2013-11-01T00:00:00Z
date_updated: 2021-01-12T06:49:46Z
day: '01'
doi: 10.1080/03605302.2013.823548
extern: 1
intvolume: '        38'
issue: '11'
month: '11'
page: 2004 - 2047
publication: Communications in Partial Differential Equations
publication_status: published
publisher: Taylor & Francis
publist_id: '5962'
quality_controlled: 0
status: public
title: Uniqueness of solutions of the Derrida-Lebowitz-Speer-Spohn equation and quantum
  drift diffusion models
type: journal_article
volume: 38
year: '2013'
...
---
_id: '1308'
abstract:
- lang: eng
  text: We derive sufficient conditions for advection-driven backward motion of the
    free boundary in a chemotaxis model with degenerate mobility. In this model, a
    porous-medium-type diffusive term and an advection term are in competition. The
    former induces forward motion, the latter may induce backward motion of the free
    boundary depending on the direction of advection. We deduce conditions on the
    growth of the initial data at the free boundary which ensure that at least initially
    the advection term is dominant. This implies local backward motion of the free
    boundary provided the advection is (locally) directed appropriately. Our result
    is based on a new class of moving test functions and Stampacchia's lemma. As a
    by-product of our estimates, we obtain quantitative bounds on the spreading of
    the support of solutions for the chemotaxis model and provide a proof for the
    finite speed of the support propagation property of solutions.
author:
- first_name: Julian L
  full_name: Julian Fischer
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
citation:
  ama: Fischer JL. Advection-driven support shrinking in a chemotaxis model with degenerate
    mobility. <i>SIAM Journal on Mathematical Analysis</i>. 2013;45(3):1585-1615.
    doi:<a href="https://doi.org/10.1137/120874291">10.1137/120874291</a>
  apa: Fischer, J. L. (2013). Advection-driven support shrinking in a chemotaxis model
    with degenerate mobility. <i>SIAM Journal on Mathematical Analysis</i>. Society
    for Industrial and Applied Mathematics . <a href="https://doi.org/10.1137/120874291">https://doi.org/10.1137/120874291</a>
  chicago: Fischer, Julian L. “Advection-Driven Support Shrinking in a Chemotaxis
    Model with Degenerate Mobility.” <i>SIAM Journal on Mathematical Analysis</i>.
    Society for Industrial and Applied Mathematics , 2013. <a href="https://doi.org/10.1137/120874291">https://doi.org/10.1137/120874291</a>.
  ieee: J. L. Fischer, “Advection-driven support shrinking in a chemotaxis model with
    degenerate mobility,” <i>SIAM Journal on Mathematical Analysis</i>, vol. 45, no.
    3. Society for Industrial and Applied Mathematics , pp. 1585–1615, 2013.
  ista: Fischer JL. 2013. Advection-driven support shrinking in a chemotaxis model
    with degenerate mobility. SIAM Journal on Mathematical Analysis. 45(3), 1585–1615.
  mla: Fischer, Julian L. “Advection-Driven Support Shrinking in a Chemotaxis Model
    with Degenerate Mobility.” <i>SIAM Journal on Mathematical Analysis</i>, vol.
    45, no. 3, Society for Industrial and Applied Mathematics , 2013, pp. 1585–615,
    doi:<a href="https://doi.org/10.1137/120874291">10.1137/120874291</a>.
  short: J.L. Fischer, SIAM Journal on Mathematical Analysis 45 (2013) 1585–1615.
date_created: 2018-12-11T11:51:17Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:49:46Z
day: '01'
doi: 10.1137/120874291
extern: 1
intvolume: '        45'
issue: '3'
month: '01'
page: 1585 - 1615
publication: SIAM Journal on Mathematical Analysis
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '5963'
quality_controlled: 0
status: public
title: Advection-driven support shrinking in a chemotaxis model with degenerate mobility
type: journal_article
volume: 45
year: '2013'
...
---
_id: '1310'
abstract:
- lang: eng
  text: We derive lower bounds on asymptotic support propagation rates for strong
    solutions of the Cauchy problem for the thin-film equation. The bounds coincide
    up to a constant factor with the previously known upper bounds and thus are sharp.
    Our results hold in case of at most three spatial dimensions and n∈. (1, 2.92).
    The result is established using weighted backward entropy inequalities with singular
    weight functions to yield a differential inequality; combined with some entropy
    production estimates, the optimal rate of propagation is obtained. To the best
    of our knowledge, these are the first lower bounds on asymptotic support propagation
    rates for higher-order nonnegativity-preserving parabolic equations.
author:
- first_name: Julian L
  full_name: Julian Fischer
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
citation:
  ama: Fischer JL. Optimal lower bounds on asymptotic support propagation rates for
    the thin-film equation. <i>Journal of Differential Equations</i>. 2013;255(10):3127-3149.
    doi:<a href="https://doi.org/10.1016/j.jde.2013.07.028">10.1016/j.jde.2013.07.028</a>
  apa: Fischer, J. L. (2013). Optimal lower bounds on asymptotic support propagation
    rates for the thin-film equation. <i>Journal of Differential Equations</i>. Academic
    Press. <a href="https://doi.org/10.1016/j.jde.2013.07.028">https://doi.org/10.1016/j.jde.2013.07.028</a>
  chicago: Fischer, Julian L. “Optimal Lower Bounds on Asymptotic Support Propagation
    Rates for the Thin-Film Equation.” <i>Journal of Differential Equations</i>. Academic
    Press, 2013. <a href="https://doi.org/10.1016/j.jde.2013.07.028">https://doi.org/10.1016/j.jde.2013.07.028</a>.
  ieee: J. L. Fischer, “Optimal lower bounds on asymptotic support propagation rates
    for the thin-film equation,” <i>Journal of Differential Equations</i>, vol. 255,
    no. 10. Academic Press, pp. 3127–3149, 2013.
  ista: Fischer JL. 2013. Optimal lower bounds on asymptotic support propagation rates
    for the thin-film equation. Journal of Differential Equations. 255(10), 3127–3149.
  mla: Fischer, Julian L. “Optimal Lower Bounds on Asymptotic Support Propagation
    Rates for the Thin-Film Equation.” <i>Journal of Differential Equations</i>, vol.
    255, no. 10, Academic Press, 2013, pp. 3127–49, doi:<a href="https://doi.org/10.1016/j.jde.2013.07.028">10.1016/j.jde.2013.07.028</a>.
  short: J.L. Fischer, Journal of Differential Equations 255 (2013) 3127–3149.
date_created: 2018-12-11T11:51:18Z
date_published: 2013-11-15T00:00:00Z
date_updated: 2021-01-12T06:49:47Z
day: '15'
doi: 10.1016/j.jde.2013.07.028
extern: 1
intvolume: '       255'
issue: '10'
month: '11'
page: 3127 - 3149
publication: Journal of Differential Equations
publication_status: published
publisher: Academic Press
publist_id: '5961'
quality_controlled: 0
status: public
title: Optimal lower bounds on asymptotic support propagation rates for the thin-film
  equation
type: journal_article
volume: 255
year: '2013'
...
---
_id: '8245'
abstract:
- lang: eng
  text: "Background: Monoclonal antibodies (mAb), such as trastuzumab are a valuable
    addition to breast cancer therapy.\r\nData obtained from neoadjuvant settings
    revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is a\r\nmajor
    mechanism of action for the mAb trastuzumab. Conflicting results still call into
    question whether disease\r\nprogression, prolonged treatment or concomitant chemotherapy
    influences ADCC and related immunological\r\nphenomena.\r\nMethods: We analyzed
    the activity of ADCC and antibody-dependent cell-mediated phagocytosis (ADCP)
    of\r\nperipheral blood mononuclear cells (PBMCs) from human epidermal growth factor
    receptor 2 (HER2/neu) positive\r\nbreast cancer patients receiving trastuzumab
    therapy either in an adjuvant (n = 13) or metastatic (n = 15) setting as\r\nwell
    as from trastuzumab treatment-naive (t-naive) HER2/neu negative patients (n =
    15). PBMCs from healthy volunteers\r\n(n = 24) were used as controls. ADCC and
    ADCP activity was correlated with the expression of antibody binding\r\nFc-gamma
    receptor (FcγR)I (CD64), FcγRII (CD32) and FcγRIII (CD16) on CD14+ (monocytes)
    and CD56+ (NK) cells, as well as the expression of CD107a+ (LAMP-1) on CD56+ cells
    and the total amount of CD4+CD25+FOXP3+ (Treg) cells. In metastatic patients,
    markers were correlated with progression-free survival (PFS).\r\nResults: ADCC
    activity was significantly down regulated in metastatic, adjuvant and t-naive
    patient cohorts as compared to healthy controls. Reduced ADCC activity was inversely
    correlated with the expression of CD107a on CD56+\r\ncells in adjuvant patients.
    ADCC and ADCP activity of the patient cohorts were similar, regardless of treatment
    duration\r\nor additional chemotherapy. PFS in metastatic patients inversely correlated
    with the number of peripheral Treg cells.\r\nConclusion: The reduction of ADCC
    in patients as compared to healthy controls calls for adjuvant strategies, such
    as\r\nimmune-enhancing agents, to improve the activity of trastuzumab. However,
    efficacy of trastuzumab-specific ADCC\r\nand ADCP appears not to be affected by
    treatment duration, disease progression or concomitant chemotherapy. This\r\nfinding
    supports the application of trastuzumab at any stage of the disease."
article_number: '307'
article_processing_charge: No
author:
- first_name: Branka
  full_name: Petricevic, Branka
  last_name: Petricevic
- first_name: Johannes
  full_name: Laengle, Johannes
  last_name: Laengle
- first_name: Josef
  full_name: Singer, Josef
  last_name: Singer
- first_name: Monika
  full_name: Sachet, Monika
  last_name: Sachet
- first_name: Judit
  full_name: Fazekas, Judit
  id: 36432834-F248-11E8-B48F-1D18A9856A87
  last_name: Fazekas
  orcid: 0000-0002-8777-3502
- first_name: Guenther
  full_name: Steger, Guenther
  last_name: Steger
- first_name: Rupert
  full_name: Bartsch, Rupert
  last_name: Bartsch
- first_name: Erika
  full_name: Jensen-Jarolim, Erika
  last_name: Jensen-Jarolim
- first_name: Michael
  full_name: Bergmann, Michael
  last_name: Bergmann
citation:
  ama: Petricevic B, Laengle J, Singer J, et al. Trastuzumab mediates antibody-dependent
    cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant
    and metastatic HER2/neu breast cancer patients. <i>Journal of Translational Medicine</i>.
    2013;11. doi:<a href="https://doi.org/10.1186/1479-5876-11-307">10.1186/1479-5876-11-307</a>
  apa: Petricevic, B., Laengle, J., Singer, J., Sachet, M., Singer, J., Steger, G.,
    … Bergmann, M. (2013). Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity
    and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast
    cancer patients. <i>Journal of Translational Medicine</i>. Springer Nature. <a
    href="https://doi.org/10.1186/1479-5876-11-307">https://doi.org/10.1186/1479-5876-11-307</a>
  chicago: Petricevic, Branka, Johannes Laengle, Josef Singer, Monika Sachet, Judit
    Singer, Guenther Steger, Rupert Bartsch, Erika Jensen-Jarolim, and Michael Bergmann.
    “Trastuzumab Mediates Antibody-Dependent Cell-Mediated Cytotoxicity and Phagocytosis
    to the Same Extent in Both Adjuvant and Metastatic HER2/Neu Breast Cancer Patients.”
    <i>Journal of Translational Medicine</i>. Springer Nature, 2013. <a href="https://doi.org/10.1186/1479-5876-11-307">https://doi.org/10.1186/1479-5876-11-307</a>.
  ieee: B. Petricevic <i>et al.</i>, “Trastuzumab mediates antibody-dependent cell-mediated
    cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic
    HER2/neu breast cancer patients,” <i>Journal of Translational Medicine</i>, vol.
    11. Springer Nature, 2013.
  ista: Petricevic B, Laengle J, Singer J, Sachet M, Singer J, Steger G, Bartsch R,
    Jensen-Jarolim E, Bergmann M. 2013. Trastuzumab mediates antibody-dependent cell-mediated
    cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic
    HER2/neu breast cancer patients. Journal of Translational Medicine. 11, 307.
  mla: Petricevic, Branka, et al. “Trastuzumab Mediates Antibody-Dependent Cell-Mediated
    Cytotoxicity and Phagocytosis to the Same Extent in Both Adjuvant and Metastatic
    HER2/Neu Breast Cancer Patients.” <i>Journal of Translational Medicine</i>, vol.
    11, 307, Springer Nature, 2013, doi:<a href="https://doi.org/10.1186/1479-5876-11-307">10.1186/1479-5876-11-307</a>.
  short: B. Petricevic, J. Laengle, J. Singer, M. Sachet, J. Singer, G. Steger, R.
    Bartsch, E. Jensen-Jarolim, M. Bergmann, Journal of Translational Medicine 11
    (2013).
date_created: 2020-08-10T11:54:34Z
date_published: 2013-12-12T00:00:00Z
date_updated: 2022-08-25T14:52:39Z
day: '12'
ddc:
- '570'
doi: 10.1186/1479-5876-11-307
extern: '1'
external_id:
  pmid:
  - '24330813'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2020-08-10T13:45:19Z
  date_updated: 2020-08-10T13:45:19Z
  file_id: '8247'
  file_name: 2013_JoTM_Petricevic.pdf
  file_size: 777311
  relation: main_file
  success: 1
file_date_updated: 2020-08-10T13:45:19Z
has_accepted_license: '1'
intvolume: '        11'
language:
- iso: eng
month: '12'
oa: 1
oa_version: None
pmid: 1
publication: Journal of Translational Medicine
publication_identifier:
  issn:
  - 1479-5876
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis
  to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2013'
...
---
_id: '827'
abstract:
- lang: eng
  text: As sessile organisms, plants have to be able to adapt to a continuously changing
    environment. Plants that perceive some of these changes as stress signals activate
    signaling pathways to modulate their development and to enable them to survive.
    The complex responses to environmental cues are to a large extent mediated by
    plant hormones that together orchestrate the final plant response. The phytohormone
    cytokinin is involved in many plant developmental processes. Recently, it has
    been established that cytokinin plays an important role in stress responses, but
    does not act alone. Indeed, the hormonal control of plant development and stress
    adaptation is the outcome of a complex network of multiple synergistic and antagonistic
    interactions between various hormones. Here, we review the recent findings on
    the cytokinin function as part of this hormonal network. We focus on the importance
    of the crosstalk between cytokinin and other hormones, such as abscisic acid,
    jasmonate, salicylic acid, ethylene, and auxin in the modulation of plant development
    and stress adaptation. Finally, the impact of the current research in the biotechnological
    industry will be discussed.
article_number: '451'
author:
- first_name: José
  full_name: O'Brien, José
  last_name: O'Brien
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: O’Brien J, Benková E. Cytokinin cross talking during biotic and abiotic stress
    responses. <i>Frontiers in Plant Science</i>. 2013;4. doi:<a href="https://doi.org/10.3389/fpls.2013.00451">10.3389/fpls.2013.00451</a>
  apa: O’Brien, J., &#38; Benková, E. (2013). Cytokinin cross talking during biotic
    and abiotic stress responses. <i>Frontiers in Plant Science</i>. Frontiers Research
    Foundation. <a href="https://doi.org/10.3389/fpls.2013.00451">https://doi.org/10.3389/fpls.2013.00451</a>
  chicago: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic
    and Abiotic Stress Responses.” <i>Frontiers in Plant Science</i>. Frontiers Research
    Foundation, 2013. <a href="https://doi.org/10.3389/fpls.2013.00451">https://doi.org/10.3389/fpls.2013.00451</a>.
  ieee: J. O’Brien and E. Benková, “Cytokinin cross talking during biotic and abiotic
    stress responses,” <i>Frontiers in Plant Science</i>, vol. 4. Frontiers Research
    Foundation, 2013.
  ista: O’Brien J, Benková E. 2013. Cytokinin cross talking during biotic and abiotic
    stress responses. Frontiers in Plant Science. 4, 451.
  mla: O’Brien, José, and Eva Benková. “Cytokinin Cross Talking during Biotic and
    Abiotic Stress Responses.” <i>Frontiers in Plant Science</i>, vol. 4, 451, Frontiers
    Research Foundation, 2013, doi:<a href="https://doi.org/10.3389/fpls.2013.00451">10.3389/fpls.2013.00451</a>.
  short: J. O’Brien, E. Benková, Frontiers in Plant Science 4 (2013).
date_created: 2018-12-11T11:48:43Z
date_published: 2013-11-19T00:00:00Z
date_updated: 2021-01-12T08:17:50Z
day: '19'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00451
ec_funded: 1
file:
- access_level: open_access
  checksum: fdc25ddd1bf9a99b99f662cdbafeddd4
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-31T10:40:38Z
  date_updated: 2020-07-14T12:48:11Z
  file_id: '5903'
  file_name: 2013_FrontiersPlant_OBrien.pdf
  file_size: 953299
  relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6821'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cytokinin cross talking during biotic and abiotic stress responses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2013'
...
---
_id: '828'
abstract:
- lang: eng
  text: The plant root system is essential for providing anchorage to the soil, supplying
    minerals and water, and synthesizing metabolites. It is a dynamic organ modulated
    by external cues such as environmental signals, water and nutrients availability,
    salinity and others. Lateral roots (LRs) are initiated from the primary root post-embryonically,
    after which they progress through discrete developmental stages which can be independently
    controlled, providing a high level of plasticity during root system formation.
    Within this review, main contributions are presented, from the classical forward
    genetic screens to the more recent high-throughput approaches, combined with computer
    model predictions, dissecting how LRs and thereby root system architecture is
    established and developed.
article_number: '537'
author:
- first_name: Candela
  full_name: Cuesta, Candela
  id: 33A3C818-F248-11E8-B48F-1D18A9856A87
  last_name: Cuesta
  orcid: 0000-0003-1923-2410
- first_name: Krzysztof T
  full_name: Wabnik, Krzysztof T
  id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
  last_name: Wabnik
  orcid: 0000-0001-7263-0560
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Cuesta C, Wabnik KT, Benková E. Systems approaches to study root architecture
    dynamics. <i>Frontiers in Plant Science</i>. 2013;4. doi:<a href="https://doi.org/10.3389/fpls.2013.00537">10.3389/fpls.2013.00537</a>
  apa: Cuesta, C., Wabnik, K. T., &#38; Benková, E. (2013). Systems approaches to
    study root architecture dynamics. <i>Frontiers in Plant Science</i>. Frontiers
    Research Foundation. <a href="https://doi.org/10.3389/fpls.2013.00537">https://doi.org/10.3389/fpls.2013.00537</a>
  chicago: Cuesta, Candela, Krzysztof T Wabnik, and Eva Benková. “Systems Approaches
    to Study Root Architecture Dynamics.” <i>Frontiers in Plant Science</i>. Frontiers
    Research Foundation, 2013. <a href="https://doi.org/10.3389/fpls.2013.00537">https://doi.org/10.3389/fpls.2013.00537</a>.
  ieee: C. Cuesta, K. T. Wabnik, and E. Benková, “Systems approaches to study root
    architecture dynamics,” <i>Frontiers in Plant Science</i>, vol. 4. Frontiers Research
    Foundation, 2013.
  ista: Cuesta C, Wabnik KT, Benková E. 2013. Systems approaches to study root architecture
    dynamics. Frontiers in Plant Science. 4, 537.
  mla: Cuesta, Candela, et al. “Systems Approaches to Study Root Architecture Dynamics.”
    <i>Frontiers in Plant Science</i>, vol. 4, 537, Frontiers Research Foundation,
    2013, doi:<a href="https://doi.org/10.3389/fpls.2013.00537">10.3389/fpls.2013.00537</a>.
  short: C. Cuesta, K.T. Wabnik, E. Benková, Frontiers in Plant Science 4 (2013).
date_created: 2018-12-11T11:48:43Z
date_published: 2013-12-26T00:00:00Z
date_updated: 2021-01-12T08:17:52Z
day: '26'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.3389/fpls.2013.00537
ec_funded: 1
file:
- access_level: open_access
  checksum: 0185b3c4d7df9a94bd3ce5a66d213506
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-31T10:36:43Z
  date_updated: 2020-07-14T12:48:11Z
  file_id: '5902'
  file_name: 2013_FrontiersPlant_Cuesta.pdf
  file_size: 710835
  relation: main_file
file_date_updated: 2020-07-14T12:48:11Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Frontiers in Plant Science
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6820'
quality_controlled: '1'
scopus_import: 1
status: public
title: Systems approaches to study root architecture dynamics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2013'
...
---
_id: '830'
abstract:
- lang: eng
  text: Upon hormonal signaling, ovules develop as lateral organs from the placenta.
    Ovule numbers ultimately determine the number of seeds that develop, and thereby
    contribute to the final seed yield in crop plants. We demonstrate here that CUP-SHAPED
    COTYLEDON 1 (CUC1), CUC2 and AINTEGUMENTA (ANT) have additive effects on ovule
    primordia formation. We show that expression of the CUC1 and CUC2 genes is required
    to redundantly regulate expression of PINFORMED1 (PIN1), which in turn is required
    for ovule primordia formation. Furthermore, our results suggest that the auxin
    response factor MONOPTEROS (MP/ARF5) may directly bind ANT, CUC1 and CUC2 and
    promote their transcription. Based on our findings, we propose an integrative
    model to describe the molecular mechanisms of the early stages of ovule development.
acknowledgement: The project and F.G. were supported by the CARIPLO Foundation (project
  2009-2990) and COST (European Cooperation in Science and Technology) action HAPRECI
  (Harnessing Plant Reproduction for Crop Improvement). E.B. and C.C. were supported
  by the European Research Council through a ‘Starting Independent Research’ grant
  (ERC-2007-Stg-207362-HCPO). We thank A.P. MacCabe (Consejo Superior de Investigaciones
  Científicas, Valencia, Spain) for critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Francesca
  full_name: Galbiati, Francesca
  last_name: Galbiati
- first_name: Dola
  full_name: Sinha Roy, Dola
  last_name: Sinha Roy
- first_name: Sara
  full_name: Simonini, Sara
  last_name: Simonini
- first_name: Mara
  full_name: Cucinotta, Mara
  last_name: Cucinotta
- first_name: Luca
  full_name: Ceccato, Luca
  last_name: Ceccato
- first_name: Candela
  full_name: Cuesta, Candela
  id: 33A3C818-F248-11E8-B48F-1D18A9856A87
  last_name: Cuesta
  orcid: 0000-0003-1923-2410
- first_name: Mária
  full_name: Šimášková, Mária
  last_name: Šimášková
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Yuri
  full_name: Kamiuchi, Yuri
  last_name: Kamiuchi
- first_name: Mitsuhiro
  full_name: Aida, Mitsuhiro
  last_name: Aida
- first_name: Dolf
  full_name: Weijers, Dolf
  last_name: Weijers
- first_name: Rüdiger
  full_name: Simon, Rüdiger
  last_name: Simon
- first_name: Simona
  full_name: Masiero, Simona
  last_name: Masiero
- first_name: Lucia
  full_name: Colombo, Lucia
  last_name: Colombo
citation:
  ama: Galbiati F, Sinha Roy D, Simonini S, et al. An integrative model of the control
    of ovule primordia formation. <i>The Plant journal for cell and molecular biology</i>.
    2013;76(3):446-455. doi:<a href="https://doi.org/10.1111/tpj.12309">10.1111/tpj.12309</a>
  apa: Galbiati, F., Sinha Roy, D., Simonini, S., Cucinotta, M., Ceccato, L., Cuesta,
    C., … Colombo, L. (2013). An integrative model of the control of ovule primordia
    formation. <i>The Plant Journal for Cell and Molecular Biology</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1111/tpj.12309">https://doi.org/10.1111/tpj.12309</a>
  chicago: Galbiati, Francesca, Dola Sinha Roy, Sara Simonini, Mara Cucinotta, Luca
    Ceccato, Candela Cuesta, Mária Šimášková, et al. “An Integrative Model of the
    Control of Ovule Primordia Formation.” <i>The Plant Journal for Cell and Molecular
    Biology</i>. Wiley-Blackwell, 2013. <a href="https://doi.org/10.1111/tpj.12309">https://doi.org/10.1111/tpj.12309</a>.
  ieee: F. Galbiati <i>et al.</i>, “An integrative model of the control of ovule primordia
    formation,” <i>The Plant journal for cell and molecular biology</i>, vol. 76,
    no. 3. Wiley-Blackwell, pp. 446–455, 2013.
  ista: Galbiati F, Sinha Roy D, Simonini S, Cucinotta M, Ceccato L, Cuesta C, Šimášková
    M, Benková E, Kamiuchi Y, Aida M, Weijers D, Simon R, Masiero S, Colombo L. 2013.
    An integrative model of the control of ovule primordia formation. The Plant journal
    for cell and molecular biology. 76(3), 446–455.
  mla: Galbiati, Francesca, et al. “An Integrative Model of the Control of Ovule Primordia
    Formation.” <i>The Plant Journal for Cell and Molecular Biology</i>, vol. 76,
    no. 3, Wiley-Blackwell, 2013, pp. 446–55, doi:<a href="https://doi.org/10.1111/tpj.12309">10.1111/tpj.12309</a>.
  short: F. Galbiati, D. Sinha Roy, S. Simonini, M. Cucinotta, L. Ceccato, C. Cuesta,
    M. Šimášková, E. Benková, Y. Kamiuchi, M. Aida, D. Weijers, R. Simon, S. Masiero,
    L. Colombo, The Plant Journal for Cell and Molecular Biology 76 (2013) 446–455.
date_created: 2018-12-11T11:48:44Z
date_published: 2013-09-19T00:00:00Z
date_updated: 2022-03-21T07:17:26Z
day: '19'
doi: 10.1111/tpj.12309
extern: '1'
external_id:
  pmid:
  - '23941199'
intvolume: '        76'
issue: '3'
language:
- iso: eng
month: '09'
oa_version: None
page: 446 - 455
pmid: 1
publication: The Plant journal for cell and molecular biology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6818'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An integrative model of the control of ovule primordia formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 76
year: '2013'
...
---
_id: '831'
abstract:
- lang: eng
  text: In Arabidopsis, lateral roots originate from pericycle cells deep within the
    primary root. New lateral root primordia (LRP) have to emerge through several
    overlaying tissues. Here, we report that auxin produced in new LRP is transported
    towards the outer tissues where it triggers cell separation by inducing both the
    auxin influx carrier LAX3 and cell-wall enzymes. LAX3 is expressed in just two
    cell files overlaying new LRP. To understand how this striking pattern of LAX3
    expression is regulated, we developed a mathematical model that captures the network
    regulating its expression and auxin transport within realistic three-dimensional
    cell and tissue geometries. Our model revealed that, for the LAX3 spatial expression
    to be robust to natural variations in root tissue geometry, an efflux carrier
    is required--later identified to be PIN3. To prevent LAX3 from being transiently
    expressed in multiple cell files, PIN3 and LAX3 must be induced consecutively,
    which we later demonstrated to be the case. Our study exemplifies how mathematical
    models can be used to direct experiments to elucidate complex developmental processes.
acknowledgement: This work was supported by an FEBS Long‐Term Fellowship (BP), an
  Intra‐European Fellowship for Career Development under the 7th framework of the
  European Commission (IEF‐2008‐220506 to BP), an EMBO Long‐Term Fellowship (BP),
  an European Reintegration Grant under the 7th framework of the European Commission
  (ERG‐2010‐276662 to BP) and the Swedish Research Council (VR 621‐2010‐5720 to IS,
  GS and KL). AMM, APF, AL, LRB, SP, NM, DMW, MO, JRK and MJB acknowledge the support
  of the Biotechnology and Biological Sciences Research Council (BBSRC) and Engineering
  and Physical Sciences Research Council (EPSRC) funding to the Centre for Plant Integrative
  Biology (CPIB); BBSRC Professorial Research Fellowship funding to DMW and MJB; Belgian
  Scientific policy (BELSPO contract MARS) to TB and MJB. We thank Bert de Rybel for
  his help in Multisite Gateway cloning.
author:
- first_name: Benjamin
  full_name: Péret, Benjamin
  last_name: Péret
- first_name: Alistair
  full_name: Middleton, Alistair M
  last_name: Middleton
- first_name: Andrew
  full_name: French, Andrew P
  last_name: French
- first_name: Antoine
  full_name: Larrieu, Antoine
  last_name: Larrieu
- first_name: Anthony
  full_name: Bishopp, Anthony
  last_name: Bishopp
- first_name: Maria
  full_name: Njo, Maria
  last_name: Njo
- first_name: Darren
  full_name: Wells, Darren M
  last_name: Wells
- first_name: Silvana
  full_name: Porco, Silvana
  last_name: Porco
- first_name: Nathan
  full_name: Mellor, Nathan
  last_name: Mellor
- first_name: Leah
  full_name: Band, Leah R
  last_name: Band
- first_name: Ilda
  full_name: Casimiro, Ilda
  last_name: Casimiro
- first_name: Jürgen
  full_name: Kleine-Vehn, Jürgen
  last_name: Kleine Vehn
- first_name: Steffen
  full_name: Vanneste, Steffen
  last_name: Vanneste
- first_name: Ilkka
  full_name: Sairanen, Ilkka
  last_name: Sairanen
- first_name: Romain
  full_name: Mallet, Romain
  last_name: Mallet
- first_name: Göran
  full_name: Sandberg, Göran
  last_name: Sandberg
- first_name: Karin
  full_name: Ljung, Karin
  last_name: Ljung
- first_name: Tom
  full_name: Beeckman, Tom
  last_name: Beeckman
- first_name: Eva
  full_name: Eva Benková
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Eric
  full_name: Kramer, Eric
  last_name: Kramer
- first_name: John
  full_name: King, John R
  last_name: King
- first_name: Ive
  full_name: De Smet, Ive
  last_name: De Smet
- first_name: Tony
  full_name: Pridmore, Tony
  last_name: Pridmore
- first_name: Markus
  full_name: Owen, Markus
  last_name: Owen
- first_name: Malcolm
  full_name: Bennett, Malcolm J
  last_name: Bennett
citation:
  ama: Péret B, Middleton A, French A, et al. Sequential induction of auxin efflux
    and influx carriers regulates lateral root emergence. <i>Molecular Systems Biology</i>.
    2013;9. doi:<a href="https://doi.org/10.1038/msb.2013.43">10.1038/msb.2013.43</a>
  apa: Péret, B., Middleton, A., French, A., Larrieu, A., Bishopp, A., Njo, M., …
    Bennett, M. (2013). Sequential induction of auxin efflux and influx carriers regulates
    lateral root emergence. <i>Molecular Systems Biology</i>. Nature Publishing Group.
    <a href="https://doi.org/10.1038/msb.2013.43">https://doi.org/10.1038/msb.2013.43</a>
  chicago: Péret, Benjamin, Alistair Middleton, Andrew French, Antoine Larrieu, Anthony
    Bishopp, Maria Njo, Darren Wells, et al. “Sequential Induction of Auxin Efflux
    and Influx Carriers Regulates Lateral Root Emergence.” <i>Molecular Systems Biology</i>.
    Nature Publishing Group, 2013. <a href="https://doi.org/10.1038/msb.2013.43">https://doi.org/10.1038/msb.2013.43</a>.
  ieee: B. Péret <i>et al.</i>, “Sequential induction of auxin efflux and influx carriers
    regulates lateral root emergence,” <i>Molecular Systems Biology</i>, vol. 9. Nature
    Publishing Group, 2013.
  ista: Péret B, Middleton A, French A, Larrieu A, Bishopp A, Njo M, Wells D, Porco
    S, Mellor N, Band L, Casimiro I, Kleine Vehn J, Vanneste S, Sairanen I, Mallet
    R, Sandberg G, Ljung K, Beeckman T, Benková E, Friml J, Kramer E, King J, De Smet
    I, Pridmore T, Owen M, Bennett M. 2013. Sequential induction of auxin efflux and
    influx carriers regulates lateral root emergence. Molecular Systems Biology. 9.
  mla: Péret, Benjamin, et al. “Sequential Induction of Auxin Efflux and Influx Carriers
    Regulates Lateral Root Emergence.” <i>Molecular Systems Biology</i>, vol. 9, Nature
    Publishing Group, 2013, doi:<a href="https://doi.org/10.1038/msb.2013.43">10.1038/msb.2013.43</a>.
  short: B. Péret, A. Middleton, A. French, A. Larrieu, A. Bishopp, M. Njo, D. Wells,
    S. Porco, N. Mellor, L. Band, I. Casimiro, J. Kleine Vehn, S. Vanneste, I. Sairanen,
    R. Mallet, G. Sandberg, K. Ljung, T. Beeckman, E. Benková, J. Friml, E. Kramer,
    J. King, I. De Smet, T. Pridmore, M. Owen, M. Bennett, Molecular Systems Biology
    9 (2013).
date_created: 2018-12-11T11:48:44Z
date_published: 2013-10-22T00:00:00Z
date_updated: 2021-01-12T08:18:03Z
day: '22'
doi: 10.1038/msb.2013.43
extern: 1
intvolume: '         9'
month: '10'
publication: Molecular Systems Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '6817'
quality_controlled: 0
status: public
title: Sequential induction of auxin efflux and influx carriers regulates lateral
  root emergence
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
volume: 9
year: '2013'
...
---
_id: '8461'
abstract:
- lang: eng
  text: Solid-state NMR provides insight into protein motion over time scales ranging
    from picoseconds to seconds. While in solution state the methodology to measure
    protein dynamics is well established, there is currently no such consensus protocol
    for measuring dynamics in solids. In this article, we perform a detailed investigation
    of measurement protocols for fast motions, i.e. motions ranging from picoseconds
    to a few microseconds, which is the range covered by dipolar coupling and relaxation
    experiments. We perform a detailed theoretical investigation how dipolar couplings
    and relaxation data can provide information about amplitudes and time scales of
    local motion. We show that the measurement of dipolar couplings is crucial for
    obtaining accurate motional parameters, while systematic errors are found when
    only relaxation data are used. Based on this realization, we investigate how the
    REDOR experiment can provide such data in a very accurate manner. We identify
    that with accurate rf calibration, and explicit consideration of rf field inhomogeneities,
    one can obtain highly accurate absolute order parameters. We then perform joint
    model-free analyses of 6 relaxation data sets and dipolar couplings, based on
    previously existing, as well as new data sets on microcrystalline ubiquitin. We
    show that nanosecond motion can be detected primarily in loop regions, and compare
    solid-state data to solution-state relaxation and RDC analyses. The protocols
    investigated here will serve as a useful basis towards the establishment of a
    routine protocol for the characterization of ps–μs motions in proteins by solid-state
    NMR.
article_processing_charge: No
article_type: original
author:
- first_name: Jens D.
  full_name: Haller, Jens D.
  last_name: Haller
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: 'Haller JD, Schanda P. Amplitudes and time scales of picosecond-to-microsecond
    motion in proteins studied by solid-state NMR: a critical evaluation of experimental
    approaches and application to crystalline ubiquitin. <i>Journal of Biomolecular
    NMR</i>. 2013;57(3):263-280. doi:<a href="https://doi.org/10.1007/s10858-013-9787-x">10.1007/s10858-013-9787-x</a>'
  apa: 'Haller, J. D., &#38; Schanda, P. (2013). Amplitudes and time scales of picosecond-to-microsecond
    motion in proteins studied by solid-state NMR: a critical evaluation of experimental
    approaches and application to crystalline ubiquitin. <i>Journal of Biomolecular
    NMR</i>. Springer Nature. <a href="https://doi.org/10.1007/s10858-013-9787-x">https://doi.org/10.1007/s10858-013-9787-x</a>'
  chicago: 'Haller, Jens D., and Paul Schanda. “Amplitudes and Time Scales of Picosecond-to-Microsecond
    Motion in Proteins Studied by Solid-State NMR: A Critical Evaluation of Experimental
    Approaches and Application to Crystalline Ubiquitin.” <i>Journal of Biomolecular
    NMR</i>. Springer Nature, 2013. <a href="https://doi.org/10.1007/s10858-013-9787-x">https://doi.org/10.1007/s10858-013-9787-x</a>.'
  ieee: 'J. D. Haller and P. Schanda, “Amplitudes and time scales of picosecond-to-microsecond
    motion in proteins studied by solid-state NMR: a critical evaluation of experimental
    approaches and application to crystalline ubiquitin,” <i>Journal of Biomolecular
    NMR</i>, vol. 57, no. 3. Springer Nature, pp. 263–280, 2013.'
  ista: 'Haller JD, Schanda P. 2013. Amplitudes and time scales of picosecond-to-microsecond
    motion in proteins studied by solid-state NMR: a critical evaluation of experimental
    approaches and application to crystalline ubiquitin. Journal of Biomolecular NMR.
    57(3), 263–280.'
  mla: 'Haller, Jens D., and Paul Schanda. “Amplitudes and Time Scales of Picosecond-to-Microsecond
    Motion in Proteins Studied by Solid-State NMR: A Critical Evaluation of Experimental
    Approaches and Application to Crystalline Ubiquitin.” <i>Journal of Biomolecular
    NMR</i>, vol. 57, no. 3, Springer Nature, 2013, pp. 263–80, doi:<a href="https://doi.org/10.1007/s10858-013-9787-x">10.1007/s10858-013-9787-x</a>.'
  short: J.D. Haller, P. Schanda, Journal of Biomolecular NMR 57 (2013) 263–280.
date_created: 2020-09-18T10:09:05Z
date_published: 2013-10-09T00:00:00Z
date_updated: 2021-01-12T08:19:26Z
day: '09'
doi: 10.1007/s10858-013-9787-x
extern: '1'
intvolume: '        57'
issue: '3'
keyword:
- Spectroscopy
- Biochemistry
language:
- iso: eng
month: '10'
oa_version: None
page: 263-280
publication: Journal of Biomolecular NMR
publication_identifier:
  issn:
  - 0925-2738
  - 1573-5001
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Amplitudes and time scales of picosecond-to-microsecond motion in proteins
  studied by solid-state NMR: a critical evaluation of experimental approaches and
  application to crystalline ubiquitin'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2013'
...
---
_id: '8462'
abstract:
- lang: eng
  text: The transition of proteins from their soluble functional state to amyloid
    fibrils and aggregates is associated with the onset of several human diseases.
    Protein aggregation often requires some structural reshaping and the subsequent
    formation of intermolecular contacts. Therefore, the study of the conformation
    of excited protein states and their ability to form oligomers is of primary importance
    for understanding the molecular basis of amyloid fibril formation. Here, we investigated
    the oligomerization processes that occur along the folding of the amyloidogenic
    human protein β2-microglobulin. The combination of real-time two-dimensional NMR
    data with real-time small-angle X-ray scattering measurements allowed us to derive
    thermodynamic and kinetic information on protein oligomerization of different
    conformational states populated along the folding pathways. In particular, we
    could demonstrate that a long-lived folding intermediate (I-state) has a higher
    propensity to oligomerize compared to the native state. Our data agree well with
    a simple five-state kinetic model that involves only monomeric and dimeric species.
    The dimers have an elongated shape with the dimerization interface located at
    the apical side of β2-microglobulin close to Pro32, the residue that has a trans
    conformation in the I-state and a cis conformation in the native (N) state. Our
    experimental data suggest that partial unfolding in the apical half of the protein
    close to Pro32 leads to an excited state conformation with enhanced propensity
    for oligomerization. This excited state becomes more populated in the transient
    I-state due to the destabilization of the native conformation by the trans-Pro32
    configuration.
article_processing_charge: No
article_type: original
author:
- first_name: E.
  full_name: Rennella, E.
  last_name: Rennella
- first_name: T.
  full_name: Cutuil, T.
  last_name: Cutuil
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: I.
  full_name: Ayala, I.
  last_name: Ayala
- first_name: F.
  full_name: Gabel, F.
  last_name: Gabel
- first_name: V.
  full_name: Forge, V.
  last_name: Forge
- first_name: A.
  full_name: Corazza, A.
  last_name: Corazza
- first_name: G.
  full_name: Esposito, G.
  last_name: Esposito
- first_name: B.
  full_name: Brutscher, B.
  last_name: Brutscher
citation:
  ama: 'Rennella E, Cutuil T, Schanda P, et al. Oligomeric states along the folding
    pathways of β2-microglobulin: Kinetics, thermodynamics, and structure. <i>Journal
    of Molecular Biology</i>. 2013;425(15):2722-2736. doi:<a href="https://doi.org/10.1016/j.jmb.2013.04.028">10.1016/j.jmb.2013.04.028</a>'
  apa: 'Rennella, E., Cutuil, T., Schanda, P., Ayala, I., Gabel, F., Forge, V., …
    Brutscher, B. (2013). Oligomeric states along the folding pathways of β2-microglobulin:
    Kinetics, thermodynamics, and structure. <i>Journal of Molecular Biology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.jmb.2013.04.028">https://doi.org/10.1016/j.jmb.2013.04.028</a>'
  chicago: 'Rennella, E., T. Cutuil, Paul Schanda, I. Ayala, F. Gabel, V. Forge, A.
    Corazza, G. Esposito, and B. Brutscher. “Oligomeric States along the Folding Pathways
    of Β2-Microglobulin: Kinetics, Thermodynamics, and Structure.” <i>Journal of Molecular
    Biology</i>. Elsevier, 2013. <a href="https://doi.org/10.1016/j.jmb.2013.04.028">https://doi.org/10.1016/j.jmb.2013.04.028</a>.'
  ieee: 'E. Rennella <i>et al.</i>, “Oligomeric states along the folding pathways
    of β2-microglobulin: Kinetics, thermodynamics, and structure,” <i>Journal of Molecular
    Biology</i>, vol. 425, no. 15. Elsevier, pp. 2722–2736, 2013.'
  ista: 'Rennella E, Cutuil T, Schanda P, Ayala I, Gabel F, Forge V, Corazza A, Esposito
    G, Brutscher B. 2013. Oligomeric states along the folding pathways of β2-microglobulin:
    Kinetics, thermodynamics, and structure. Journal of Molecular Biology. 425(15),
    2722–2736.'
  mla: 'Rennella, E., et al. “Oligomeric States along the Folding Pathways of Β2-Microglobulin:
    Kinetics, Thermodynamics, and Structure.” <i>Journal of Molecular Biology</i>,
    vol. 425, no. 15, Elsevier, 2013, pp. 2722–36, doi:<a href="https://doi.org/10.1016/j.jmb.2013.04.028">10.1016/j.jmb.2013.04.028</a>.'
  short: E. Rennella, T. Cutuil, P. Schanda, I. Ayala, F. Gabel, V. Forge, A. Corazza,
    G. Esposito, B. Brutscher, Journal of Molecular Biology 425 (2013) 2722–2736.
date_created: 2020-09-18T10:09:12Z
date_published: 2013-08-09T00:00:00Z
date_updated: 2022-08-25T14:56:24Z
day: '09'
doi: 10.1016/j.jmb.2013.04.028
extern: '1'
intvolume: '       425'
issue: '15'
keyword:
- Molecular Biology
language:
- iso: eng
month: '08'
oa_version: None
page: 2722-2736
publication: Journal of Molecular Biology
publication_identifier:
  issn:
  - 0022-2836
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Oligomeric states along the folding pathways of β2-microglobulin: Kinetics,
  thermodynamics, and structure'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 425
year: '2013'
...
---
_id: '894'
abstract:
- lang: eng
  text: 'Background: Genetic variation at the melanocortin-1 receptor (MC1R) gene
    is correlated with melanin color variation in many birds. Feral pigeons (Columba
    livia) show two major melanin-based colorations: a red coloration due to pheomelanic
    pigment and a black coloration due to eumelanic pigment. Furthermore, within each
    color type, feral pigeons display continuous variation in the amount of melanin
    pigment present in the feathers, with individuals varying from pure white to a
    full dark melanic color. Coloration is highly heritable and it has been suggested
    that it is under natural or sexual selection, or both. Our objective was to investigate
    whether MC1R allelic variants are associated with plumage color in feral pigeons.
    Findings. We sequenced 888 bp of the coding sequence of MC1R among pigeons varying
    both in the type, eumelanin or pheomelanin, and the amount of melanin in their
    feathers. We detected 10 non-synonymous substitutions and 2 synonymous substitution
    but none of them were associated with a plumage type. It remains possible that
    non-synonymous substitutions that influence coloration are present in the short
    MC1R fragment that we did not sequence but this seems unlikely because we analyzed
    the entire functionally important region of the gene. Conclusions: Our results
    show that color differences among feral pigeons are probably not attributable
    to amino acid variation at the MC1R locus. Therefore, variation in regulatory
    regions of MC1R or variation in other genes may be responsible for the color polymorphism
    of feral pigeons.'
acknowledgement: Romain Derelle was supported by grant from Plan Nacional 004302 BFU2012-31329.
  Fyodor A Kondrashov was supported by grants HHMI (Howard Hughes Medical Institute)
  003803 and EMBO 003691 EUI-EURYIP-2011-4320.
author:
- first_name: Romain
  full_name: Derelle, Romain
  last_name: Derelle
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Vladimir
  full_name: Arkhipov, Vladimir
  last_name: Arkhipov
- first_name: Hélène
  full_name: Corbel, Hélène
  last_name: Corbel
- first_name: Adrien
  full_name: Frantz, Adrien
  last_name: Frantz
- first_name: Julien
  full_name: Gasparini, Julien
  last_name: Gasparini
- first_name: Lisa
  full_name: Jacquin, Lisa
  last_name: Jacquin
- first_name: Gwenaël
  full_name: Jacob, Gwenaël
  last_name: Jacob
- first_name: Sophie
  full_name: Thibault, Sophie
  last_name: Thibault
- first_name: Emmanuelle
  full_name: Baudry, Emmanuelle
  last_name: Baudry
citation:
  ama: Derelle R, Kondrashov F, Arkhipov V, et al. Color differences among feral pigeons
    (Columba livia) are not attributable to sequence variation in the coding region
    of the melanocortin-1 receptor gene MC1R. <i>BMC Research Notes</i>. 2013;6(1).
    doi:<a href="https://doi.org/10.1186/1756-0500-6-310">10.1186/1756-0500-6-310</a>
  apa: Derelle, R., Kondrashov, F., Arkhipov, V., Corbel, H., Frantz, A., Gasparini,
    J., … Baudry, E. (2013). Color differences among feral pigeons (Columba livia)
    are not attributable to sequence variation in the coding region of the melanocortin-1
    receptor gene MC1R. <i>BMC Research Notes</i>. BioMed Central. <a href="https://doi.org/10.1186/1756-0500-6-310">https://doi.org/10.1186/1756-0500-6-310</a>
  chicago: Derelle, Romain, Fyodor Kondrashov, Vladimir Arkhipov, Hélène Corbel, Adrien
    Frantz, Julien Gasparini, Lisa Jacquin, Gwenaël Jacob, Sophie Thibault, and Emmanuelle
    Baudry. “Color Differences among Feral Pigeons (Columba Livia) Are Not Attributable
    to Sequence Variation in the Coding Region of the Melanocortin-1 Receptor Gene
    MC1R.” <i>BMC Research Notes</i>. BioMed Central, 2013. <a href="https://doi.org/10.1186/1756-0500-6-310">https://doi.org/10.1186/1756-0500-6-310</a>.
  ieee: R. Derelle <i>et al.</i>, “Color differences among feral pigeons (Columba
    livia) are not attributable to sequence variation in the coding region of the
    melanocortin-1 receptor gene MC1R,” <i>BMC Research Notes</i>, vol. 6, no. 1.
    BioMed Central, 2013.
  ista: Derelle R, Kondrashov F, Arkhipov V, Corbel H, Frantz A, Gasparini J, Jacquin
    L, Jacob G, Thibault S, Baudry E. 2013. Color differences among feral pigeons
    (Columba livia) are not attributable to sequence variation in the coding region
    of the melanocortin-1 receptor gene MC1R. BMC Research Notes. 6(1).
  mla: Derelle, Romain, et al. “Color Differences among Feral Pigeons (Columba Livia)
    Are Not Attributable to Sequence Variation in the Coding Region of the Melanocortin-1
    Receptor Gene MC1R.” <i>BMC Research Notes</i>, vol. 6, no. 1, BioMed Central,
    2013, doi:<a href="https://doi.org/10.1186/1756-0500-6-310">10.1186/1756-0500-6-310</a>.
  short: R. Derelle, F. Kondrashov, V. Arkhipov, H. Corbel, A. Frantz, J. Gasparini,
    L. Jacquin, G. Jacob, S. Thibault, E. Baudry, BMC Research Notes 6 (2013).
date_created: 2018-12-11T11:49:04Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T08:21:25Z
day: '01'
doi: 10.1186/1756-0500-6-310
extern: '1'
intvolume: '         6'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
publication: BMC Research Notes
publication_status: published
publisher: BioMed Central
publist_id: '6752'
status: public
title: Color differences among feral pigeons (Columba livia) are not attributable
  to sequence variation in the coding region of the melanocortin-1 receptor gene MC1R
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2013'
...
---
_id: '899'
abstract:
- lang: eng
  text: Understanding fitness landscapes, a conceptual depiction of the genotype-to-phenotype
    relationship, is crucial to many areas of biology. Two aspects of fitness landscapes
    are the focus of contemporary studies of molecular evolution. First, the local
    shape of the fitness landscape defined by the contribution of individual alleles
    to fitness that is independent of all genetic interactions. Second, the global,
    multidimensional fitness landscape shape determined by how interactions between
    alleles at different loci change each other’s fitness impact, or epistasis. In
    explaining the high amino-acid usage (u), we focused on the global shape of the
    fitness landscape, ignoring the perturbations at individual sites.
author:
- first_name: Michael
  full_name: Breen, Michael S
  last_name: Breen
- first_name: Carsten
  full_name: Kemena, Carsten
  last_name: Kemena
- first_name: Peter
  full_name: Vlasov, Peter K
  last_name: Vlasov
- first_name: Cédric
  full_name: Notredame, Cédric
  last_name: Notredame
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Breen M, Kemena C, Vlasov P, Notredame C, Kondrashov F. Breen et al. reply.
    <i>Nature</i>. 2013;497(7451):E2-E3. doi:<a href="https://doi.org/10.1038/nature12220">10.1038/nature12220</a>
  apa: Breen, M., Kemena, C., Vlasov, P., Notredame, C., &#38; Kondrashov, F. (2013).
    Breen et al. reply. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nature12220">https://doi.org/10.1038/nature12220</a>
  chicago: Breen, Michael, Carsten Kemena, Peter Vlasov, Cédric Notredame, and Fyodor
    Kondrashov. “Breen et Al. Reply.” <i>Nature</i>. Nature Publishing Group, 2013.
    <a href="https://doi.org/10.1038/nature12220">https://doi.org/10.1038/nature12220</a>.
  ieee: M. Breen, C. Kemena, P. Vlasov, C. Notredame, and F. Kondrashov, “Breen et
    al. reply,” <i>Nature</i>, vol. 497, no. 7451. Nature Publishing Group, pp. E2–E3,
    2013.
  ista: Breen M, Kemena C, Vlasov P, Notredame C, Kondrashov F. 2013. Breen et al.
    reply. Nature. 497(7451), E2–E3.
  mla: Breen, Michael, et al. “Breen et Al. Reply.” <i>Nature</i>, vol. 497, no. 7451,
    Nature Publishing Group, 2013, pp. E2–3, doi:<a href="https://doi.org/10.1038/nature12220">10.1038/nature12220</a>.
  short: M. Breen, C. Kemena, P. Vlasov, C. Notredame, F. Kondrashov, Nature 497 (2013)
    E2–E3.
date_created: 2018-12-11T11:49:05Z
date_published: 2013-05-30T00:00:00Z
date_updated: 2021-01-12T08:21:40Z
day: '30'
doi: 10.1038/nature12220
extern: 1
intvolume: '       497'
issue: '7451'
month: '05'
page: E2 - E3
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '6747'
quality_controlled: 0
status: public
title: Breen et al. reply
type: journal_article
volume: 497
year: '2013'
...
---
_id: '905'
abstract:
- lang: eng
  text: A survey of avifauna was carried out in the Mys Shmidta area, north Chukotka,
    Russia from 8 June to 12 July 2011. A total of 90 species was recorded in the
    area, which together with literature data made a final list of 104 species. For
    several species this area is beyond the northern, north-eastern or north-western
    limits of their known distribution. We collected new data for 19 globally or locally
    threatened species. Tundra Swan Cygnus columbianus, Emperor Goose Anser canagica,
    American Golden Plover Pluvialis dominica, Western Sandpiper Calidris mauri, Semipalmated
    Sandpiper C. pusilla, Northern House Martin Delichon urbica and Barn Swallow Hirundo
    rustica were all confirmed to be breeding. Breeding of Brent Goose Branta bernicla
    nigricans, Spectacled Eider Somateria fischeri and Steller's Eider Polysticta
    stelleri was judged to be 'very likely'. There was no evidence for breeding of
    Ross's Gull Rhodostethia rosea despite several records. Two Eurasian Dotterels
    Eudromias morinellus were recorded displaying for the first time in the area,
    but the status of the species is unclear. The area is important for Snowy Owl
    Nyctea scandiaca, and as moulting grounds for Emperor Goose. Canada Goose Branta
    canadensis, Baikal Teal Anas formosa, Bar-tailed Godwit Limosa lapponica, Slaty-backed
    Gull Larus schistisagus, Thayer's Gull L. thayeri, Black-headed Gull L. ridibundus,
    White-tailed Eagle Haliaeetus albicilla, Steller's Sea Eagle H. pelagicus, Osprey
    Pandion haliaetus, Arctic Warbler Phylloscopus borealis and House Sparrow Passer
    domesticus are more likely to be rare vagrants or migrants. An observation of
    a Pine Siskin Carduelis pinus is the first record for Eurasia.
acknowledgement: We thank Natalya Kveten and Oksana Makarova, heads of administrations
  of Mys Shmidta and Ryrkaypiy for hospitality and for help with organising our excursions.
  Warm thanks too to Pavel Tomkovich for useful comments on local birds and ornithological
  literature. We are very grateful to The David and Lucile Packard Foundation for
  the support to Birds Russia’s Spoon-billed Sandpiper  conservation  programme  in  2011
  and to Evgeny Syroechkovsky Jr, the leader of the Spoon-billed Sandpiper conservation
  team in Russia.
author:
- first_name: Vladimir
  full_name: Arkhipov, Vladimir Y
  last_name: Arkhipov
- first_name: T
  full_name: Noah T
  last_name: Noah
- first_name: Steffen
  full_name: Koschkar, Steffen
  last_name: Koschkar
- first_name: Fyodor
  full_name: Fyodor Kondrashov
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Arkhipov V, Noah T, Koschkar S, Kondrashov F. Birds of Mys Shmidta, north Chukotka,
    Russia. <i>Forktail</i>. 2013;(29):25-30.
  apa: Arkhipov, V., Noah, T., Koschkar, S., &#38; Kondrashov, F. (2013). Birds of
    Mys Shmidta, north Chukotka, Russia. <i>Forktail</i>. Oriental Bird Club.
  chicago: Arkhipov, Vladimir, T Noah, Steffen Koschkar, and Fyodor Kondrashov. “Birds
    of Mys Shmidta, North Chukotka, Russia.” <i>Forktail</i>. Oriental Bird Club,
    2013.
  ieee: V. Arkhipov, T. Noah, S. Koschkar, and F. Kondrashov, “Birds of Mys Shmidta,
    north Chukotka, Russia,” <i>Forktail</i>, no. 29. Oriental Bird Club, pp. 25–30,
    2013.
  ista: Arkhipov V, Noah T, Koschkar S, Kondrashov F. 2013. Birds of Mys Shmidta,
    north Chukotka, Russia. Forktail. (29), 25–30.
  mla: Arkhipov, Vladimir, et al. “Birds of Mys Shmidta, North Chukotka, Russia.”
    <i>Forktail</i>, no. 29, Oriental Bird Club, 2013, pp. 25–30.
  short: V. Arkhipov, T. Noah, S. Koschkar, F. Kondrashov, Forktail (2013) 25–30.
date_created: 2018-12-11T11:49:07Z
date_published: 2013-09-01T00:00:00Z
date_updated: 2021-01-12T08:21:48Z
day: '01'
extern: 1
issue: '29'
main_file_link:
- open_access: '1'
  url: http://orientalbirdclub.org/forktail29/
month: '09'
oa: 1
page: 25 - 30
publication: Forktail
publication_status: published
publisher: Oriental Bird Club
publist_id: '6741'
quality_controlled: 0
status: public
title: Birds of Mys Shmidta, north Chukotka, Russia
type: journal_article
year: '2013'
...
---
_id: '9055'
abstract:
- lang: eng
  text: Spontaneous formation of colonies of bacteria or flocks of birds are examples
    of self-organization in active living matter. Here, we demonstrate a form of self-organization
    from nonequilibrium driving forces in a suspension of synthetic photoactivated
    colloidal particles. They lead to two-dimensional "living crystals," which form,
    break, explode, and re-form elsewhere. The dynamic assembly results from a competition
    between self-propulsion of particles and an attractive interaction induced respectively
    by osmotic and phoretic effects and activated by light. We measured a transition
    from normal to giant-number fluctuations. Our experiments are quantitatively described
    by simple numerical simulations. We show that the existence of the living crystals
    is intrinsically related to the out-of-equilibrium collisions of the self-propelled
    particles.
article_processing_charge: No
article_type: original
author:
- first_name: Jérémie A
  full_name: Palacci, Jérémie A
  id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
  last_name: Palacci
  orcid: 0000-0002-7253-9465
- first_name: S.
  full_name: Sacanna, S.
  last_name: Sacanna
- first_name: A. P.
  full_name: Steinberg, A. P.
  last_name: Steinberg
- first_name: D. J.
  full_name: Pine, D. J.
  last_name: Pine
- first_name: P. M.
  full_name: Chaikin, P. M.
  last_name: Chaikin
citation:
  ama: Palacci JA, Sacanna S, Steinberg AP, Pine DJ, Chaikin PM. Living crystals of
    light-activated colloidal surfers. <i>Science</i>. 2013;339(6122):936-940. doi:<a
    href="https://doi.org/10.1126/science.1230020">10.1126/science.1230020</a>
  apa: Palacci, J. A., Sacanna, S., Steinberg, A. P., Pine, D. J., &#38; Chaikin,
    P. M. (2013). Living crystals of light-activated colloidal surfers. <i>Science</i>.
    American Association for the Advancement of Science . <a href="https://doi.org/10.1126/science.1230020">https://doi.org/10.1126/science.1230020</a>
  chicago: Palacci, Jérémie A, S. Sacanna, A. P. Steinberg, D. J. Pine, and P. M.
    Chaikin. “Living Crystals of Light-Activated Colloidal Surfers.” <i>Science</i>.
    American Association for the Advancement of Science , 2013. <a href="https://doi.org/10.1126/science.1230020">https://doi.org/10.1126/science.1230020</a>.
  ieee: J. A. Palacci, S. Sacanna, A. P. Steinberg, D. J. Pine, and P. M. Chaikin,
    “Living crystals of light-activated colloidal surfers,” <i>Science</i>, vol. 339,
    no. 6122. American Association for the Advancement of Science , pp. 936–940, 2013.
  ista: Palacci JA, Sacanna S, Steinberg AP, Pine DJ, Chaikin PM. 2013. Living crystals
    of light-activated colloidal surfers. Science. 339(6122), 936–940.
  mla: Palacci, Jérémie A., et al. “Living Crystals of Light-Activated Colloidal Surfers.”
    <i>Science</i>, vol. 339, no. 6122, American Association for the Advancement of
    Science , 2013, pp. 936–40, doi:<a href="https://doi.org/10.1126/science.1230020">10.1126/science.1230020</a>.
  short: J.A. Palacci, S. Sacanna, A.P. Steinberg, D.J. Pine, P.M. Chaikin, Science
    339 (2013) 936–940.
date_created: 2021-02-01T14:37:29Z
date_published: 2013-02-22T00:00:00Z
date_updated: 2022-08-25T14:57:43Z
day: '22'
doi: 10.1126/science.1230020
extern: '1'
external_id:
  pmid:
  - '23371555'
intvolume: '       339'
issue: '6122'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '02'
oa_version: None
page: 936-940
pmid: 1
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: 'American Association for the Advancement of Science '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Living crystals of light-activated colloidal surfers
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 339
year: '2013'
...
