---
_id: '1500'
abstract:
- lang: eng
  text: In this poster, we present methods for randomly generating hybrid automata
    with affine differential equations, invariants, guards, and assignments. Selecting
    an arbitrary affine function from the set of all affine functions results in a
    low likelihood of generating hybrid automata with diverse and interesting behaviors,
    as there are an uncountable number of elements in the set of all affine functions.
    Instead, we partition the set of all affine functions into potentially interesting
    classes and randomly select elements from these classes. For example, we partition
    the set of all affine differential equations by using restrictions on eigenvalues
    such as those that yield stable, unstable, etc. equilibrium points. We partition
    the components describing discrete behavior (guards, assignments, and invariants)
    to allow either time-dependent or state-dependent switching, and in particular
    provide the ability to generate subclasses of piecewise-affine hybrid automata.
    Our preliminary experimental results with a prototype tool called HyRG (Hybrid
    Random Generator) illustrate the feasibility of this generation method to automatically
    create standard hybrid automaton examples like the bouncing ball and thermostat.
alternative_title:
- '18th ACM International Conference on Hybrid Systems: Computation and Control, HSCC
  2015'
author:
- first_name: Luan
  full_name: Nguyen, Luan V
  last_name: Nguyen
- first_name: Christian
  full_name: Christian Schilling
  id: 3A2F4DCE-F248-11E8-B48F-1D18A9856A87
  last_name: Schilling
  orcid: 0000-0003-3658-1065
- first_name: Sergiy
  full_name: Sergiy Bogomolov
  id: 369D9A44-F248-11E8-B48F-1D18A9856A87
  last_name: Bogomolov
  orcid: 0000-0002-0686-0365
- first_name: Taylor
  full_name: Johnson, Taylor T
  last_name: Johnson
citation:
  ama: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. <i>Poster: HyRG: A Random Generation
    Tool for Affine Hybrid Automata</i>. Springer; 2015:289-290. doi:<a href="https://doi.org/10.1145/2728606.2728650">10.1145/2728606.2728650</a>'
  apa: 'Nguyen, L., Schilling, C., Bogomolov, S., &#38; Johnson, T. (2015). <i>Poster:
    HyRG: A random generation tool for affine hybrid automata</i>. <i>HSCC: Hybrid
    Systems - Computation and Control</i> (pp. 289–290). Springer. <a href="https://doi.org/10.1145/2728606.2728650">https://doi.org/10.1145/2728606.2728650</a>'
  chicago: 'Nguyen, Luan, Christian Schilling, Sergiy Bogomolov, and Taylor Johnson.
    <i>Poster: HyRG: A Random Generation Tool for Affine Hybrid Automata</i>. <i>HSCC:
    Hybrid Systems - Computation and Control</i>. Springer, 2015. <a href="https://doi.org/10.1145/2728606.2728650">https://doi.org/10.1145/2728606.2728650</a>.'
  ieee: 'L. Nguyen, C. Schilling, S. Bogomolov, and T. Johnson, <i>Poster: HyRG: A
    random generation tool for affine hybrid automata</i>. Springer, 2015, pp. 289–290.'
  ista: 'Nguyen L, Schilling C, Bogomolov S, Johnson T. 2015. Poster: HyRG: A random
    generation tool for affine hybrid automata, Springer,p.'
  mla: 'Nguyen, Luan, et al. “Poster: HyRG: A Random Generation Tool for Affine Hybrid
    Automata.” <i>HSCC: Hybrid Systems - Computation and Control</i>, Springer, 2015,
    pp. 289–90, doi:<a href="https://doi.org/10.1145/2728606.2728650">10.1145/2728606.2728650</a>.'
  short: 'L. Nguyen, C. Schilling, S. Bogomolov, T. Johnson, Poster: HyRG: A Random
    Generation Tool for Affine Hybrid Automata, Springer, 2015.'
date_created: 2018-12-11T11:52:23Z
date_published: 2015-04-14T00:00:00Z
date_updated: 2019-04-26T07:22:03Z
day: '14'
doi: 10.1145/2728606.2728650
extern: 1
month: '04'
page: 289 - 290
publication: 'HSCC: Hybrid Systems - Computation and Control'
publication_status: published
publisher: Springer
publist_id: '5678'
quality_controlled: 0
status: public
title: 'Poster: HyRG: A random generation tool for affine hybrid automata'
type: conference_poster
year: '2015'
...
---
_id: '1501'
abstract:
- lang: eng
  text: 'We consider Markov decision processes (MDPs) which are a standard model for
    probabilistic systems. We focus on qualitative properties for MDPs that can express
    that desired behaviors of the system arise almost-surely (with probability 1)
    or with positive probability. We introduce a new simulation relation to capture
    the refinement relation of MDPs with respect to qualitative properties, and present
    discrete graph algorithms with quadratic complexity to compute the simulation
    relation. We present an automated technique for assume-guarantee style reasoning
    for compositional analysis of two-player games by giving a counterexample guided
    abstraction-refinement approach to compute our new simulation relation. We show
    a tight link between two-player games and MDPs, and as a consequence the results
    for games are lifted to MDPs with qualitative properties. We have implemented
    our algorithms and show that the compositional analysis leads to significant improvements. '
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
  Grant No. P23499- N23, FWF NFN Grant No. S11407-N23, FWF Grant S11403-N23 (RiSE),
  and FWF Grant Z211-N23 (Wittgenstein Award), ERC Start Grant (279307: Graph Games),
  Microsoft faculty fellows award, the ERC Advanced Grant QUAREM (Quantitative Reactive
  Modeling).'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Chmelik, Martin
  id: 3624234E-F248-11E8-B48F-1D18A9856A87
  last_name: Chmelik
- first_name: Przemyslaw
  full_name: Daca, Przemyslaw
  id: 49351290-F248-11E8-B48F-1D18A9856A87
  last_name: Daca
citation:
  ama: Chatterjee K, Chmelik M, Daca P. CEGAR for compositional analysis of qualitative
    properties in Markov decision processes. <i>Formal Methods in System Design</i>.
    2015;47(2):230-264. doi:<a href="https://doi.org/10.1007/s10703-015-0235-2">10.1007/s10703-015-0235-2</a>
  apa: Chatterjee, K., Chmelik, M., &#38; Daca, P. (2015). CEGAR for compositional
    analysis of qualitative properties in Markov decision processes. <i>Formal Methods
    in System Design</i>. Springer. <a href="https://doi.org/10.1007/s10703-015-0235-2">https://doi.org/10.1007/s10703-015-0235-2</a>
  chicago: Chatterjee, Krishnendu, Martin Chmelik, and Przemyslaw Daca. “CEGAR for
    Compositional Analysis of Qualitative Properties in Markov Decision Processes.”
    <i>Formal Methods in System Design</i>. Springer, 2015. <a href="https://doi.org/10.1007/s10703-015-0235-2">https://doi.org/10.1007/s10703-015-0235-2</a>.
  ieee: K. Chatterjee, M. Chmelik, and P. Daca, “CEGAR for compositional analysis
    of qualitative properties in Markov decision processes,” <i>Formal Methods in
    System Design</i>, vol. 47, no. 2. Springer, pp. 230–264, 2015.
  ista: Chatterjee K, Chmelik M, Daca P. 2015. CEGAR for compositional analysis of
    qualitative properties in Markov decision processes. Formal Methods in System
    Design. 47(2), 230–264.
  mla: Chatterjee, Krishnendu, et al. “CEGAR for Compositional Analysis of Qualitative
    Properties in Markov Decision Processes.” <i>Formal Methods in System Design</i>,
    vol. 47, no. 2, Springer, 2015, pp. 230–64, doi:<a href="https://doi.org/10.1007/s10703-015-0235-2">10.1007/s10703-015-0235-2</a>.
  short: K. Chatterjee, M. Chmelik, P. Daca, Formal Methods in System Design 47 (2015)
    230–264.
date_created: 2018-12-11T11:52:23Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2023-09-07T11:58:33Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.1007/s10703-015-0235-2
ec_funded: 1
intvolume: '        47'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1405.0835
month: '10'
oa: 1
oa_version: Preprint
page: 230 - 264
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2587B514-B435-11E9-9278-68D0E5697425
  name: Microsoft Research Faculty Fellowship
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '5677'
quality_controlled: '1'
related_material:
  record:
  - id: '1155'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: CEGAR for compositional analysis of qualitative properties in Markov decision
  processes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2015'
...
---
_id: '1502'
abstract:
- lang: eng
  text: We extend the theory of input-output conformance with operators for merge
    and quotient. The former is useful when testing against multiple requirements
    or views. The latter can be used to generate tests for patches of an already tested
    system. Both operators can combine systems with different action alphabets, which
    is usually the case when constructing complex systems and specifications from
    parts, for instance different views as well as newly defined functionality of
    a~previous version of the system.
acknowledgement: "This research was funded in part by the European Research Council
  (ERC) under grant agreement 267989 (QUAREM), by the Austrian Science Fund (FWF)
  projects S11402-N23(RiSE) and Z211-N23 (Wittgestein Award), by People Programme
  (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013)
  under REA grant agreement 291734, and by the ARTEMIS JU under grant agreement 295373
  (nSafeCer).  Jan Křetínský has been partially supported by the Czech Science Foundation,
  grant No.  P202/12/G061.  Nikola Beneš has been supported by the\r\nMEYS project
  No. CZ.1.07/2.3.00/30.0009 Employment of Newly Graduated Doctors of Science for
  Scientific Excellence."
alternative_title:
- 'Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
  Software Engineering '
author:
- first_name: Nikola
  full_name: Beneš, Nikola
  last_name: Beneš
- first_name: Przemyslaw
  full_name: Daca, Przemyslaw
  id: 49351290-F248-11E8-B48F-1D18A9856A87
  last_name: Daca
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Jan
  full_name: Kretinsky, Jan
  id: 44CEF464-F248-11E8-B48F-1D18A9856A87
  last_name: Kretinsky
  orcid: 0000-0002-8122-2881
- first_name: Dejan
  full_name: Nickovic, Dejan
  last_name: Nickovic
citation:
  ama: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. Complete composition
    operators for IOCO-testing theory. In: ACM; 2015:101-110. doi:<a href="https://doi.org/10.1145/2737166.2737175">10.1145/2737166.2737175</a>'
  apa: 'Beneš, N., Daca, P., Henzinger, T. A., Kretinsky, J., &#38; Nickovic, D. (2015).
    Complete composition operators for IOCO-testing theory (pp. 101–110). Presented
    at the CBSE: Component-Based Software Engineering , Montreal, QC, Canada: ACM.
    <a href="https://doi.org/10.1145/2737166.2737175">https://doi.org/10.1145/2737166.2737175</a>'
  chicago: Beneš, Nikola, Przemyslaw Daca, Thomas A Henzinger, Jan Kretinsky, and
    Dejan Nickovic. “Complete Composition Operators for IOCO-Testing Theory,” 101–10.
    ACM, 2015. <a href="https://doi.org/10.1145/2737166.2737175">https://doi.org/10.1145/2737166.2737175</a>.
  ieee: 'N. Beneš, P. Daca, T. A. Henzinger, J. Kretinsky, and D. Nickovic, “Complete
    composition operators for IOCO-testing theory,” presented at the CBSE: Component-Based
    Software Engineering , Montreal, QC, Canada, 2015, pp. 101–110.'
  ista: 'Beneš N, Daca P, Henzinger TA, Kretinsky J, Nickovic D. 2015. Complete composition
    operators for IOCO-testing theory. CBSE: Component-Based Software Engineering
    , Proceedings of the 18th International ACM SIGSOFT Symposium on Component-Based
    Software Engineering , , 101–110.'
  mla: Beneš, Nikola, et al. <i>Complete Composition Operators for IOCO-Testing Theory</i>.
    ACM, 2015, pp. 101–10, doi:<a href="https://doi.org/10.1145/2737166.2737175">10.1145/2737166.2737175</a>.
  short: N. Beneš, P. Daca, T.A. Henzinger, J. Kretinsky, D. Nickovic, in:, ACM, 2015,
    pp. 101–110.
conference:
  end_date: 2015-05-08
  location: Montreal, QC, Canada
  name: 'CBSE: Component-Based Software Engineering '
  start_date: 2015-05-04
date_created: 2018-12-11T11:52:24Z
date_published: 2015-05-01T00:00:00Z
date_updated: 2023-09-07T11:58:33Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
- _id: KrCh
doi: 10.1145/2737166.2737175
ec_funded: 1
file:
- access_level: open_access
  checksum: c6ce681035c163a158751f240cb7d389
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:46Z
  date_updated: 2020-07-14T12:44:59Z
  file_id: '5303'
  file_name: IST-2016-625-v1+1_conf-cbse-BenesDHKN15.pdf
  file_size: 467561
  relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 101 - 110
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_identifier:
  isbn:
  - 978-1-4503-3471-6
publication_status: published
publisher: ACM
publist_id: '5676'
pubrep_id: '625'
quality_controlled: '1'
related_material:
  record:
  - id: '1155'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Complete composition operators for IOCO-testing theory
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1503'
abstract:
- lang: eng
  text: A Herman-Avila-Bochi type formula is obtained for the average sum of the top
    d Lyapunov exponents over a one-parameter family of double-struck G-cocycles,
    where double-struck G is the group that leaves a certain, non-degenerate Hermitian
    form of signature (c, d) invariant. The generic example of such a group is the
    pseudo-unitary group U(c, d) or, in the case c = d, the Hermitian-symplectic group
    HSp(2d) which naturally appears for cocycles related to Schrödinger operators.
    In the case d = 1, the formula for HSp(2d) cocycles reduces to the Herman-Avila-Bochi
    formula for SL(2, ℝ) cocycles.
author:
- first_name: Christian
  full_name: Sadel, Christian
  id: 4760E9F8-F248-11E8-B48F-1D18A9856A87
  last_name: Sadel
  orcid: 0000-0001-8255-3968
citation:
  ama: Sadel C. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
    and Hermitian-symplectic-cocycles. <i>Ergodic Theory and Dynamical Systems</i>.
    2015;35(5):1582-1591. doi:<a href="https://doi.org/10.1017/etds.2013.103">10.1017/etds.2013.103</a>
  apa: Sadel, C. (2015). A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
    and Hermitian-symplectic-cocycles. <i>Ergodic Theory and Dynamical Systems</i>.
    Cambridge University Press. <a href="https://doi.org/10.1017/etds.2013.103">https://doi.org/10.1017/etds.2013.103</a>
  chicago: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional
    Pseudo-Unitary and Hermitian-Symplectic-Cocycles.” <i>Ergodic Theory and Dynamical
    Systems</i>. Cambridge University Press, 2015. <a href="https://doi.org/10.1017/etds.2013.103">https://doi.org/10.1017/etds.2013.103</a>.
  ieee: C. Sadel, “A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
    and Hermitian-symplectic-cocycles,” <i>Ergodic Theory and Dynamical Systems</i>,
    vol. 35, no. 5. Cambridge University Press, pp. 1582–1591, 2015.
  ista: Sadel C. 2015. A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary
    and Hermitian-symplectic-cocycles. Ergodic Theory and Dynamical Systems. 35(5),
    1582–1591.
  mla: Sadel, Christian. “A Herman-Avila-Bochi Formula for Higher-Dimensional Pseudo-Unitary
    and Hermitian-Symplectic-Cocycles.” <i>Ergodic Theory and Dynamical Systems</i>,
    vol. 35, no. 5, Cambridge University Press, 2015, pp. 1582–91, doi:<a href="https://doi.org/10.1017/etds.2013.103">10.1017/etds.2013.103</a>.
  short: C. Sadel, Ergodic Theory and Dynamical Systems 35 (2015) 1582–1591.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-03-14T00:00:00Z
date_updated: 2021-01-12T06:51:13Z
day: '14'
doi: 10.1017/etds.2013.103
extern: '1'
intvolume: '        35'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1307.8414
month: '03'
oa: 1
oa_version: Preprint
page: 1582 - 1591
publication: Ergodic Theory and Dynamical Systems
publication_status: published
publisher: Cambridge University Press
publist_id: '5675'
quality_controlled: '1'
status: public
title: A Herman-Avila-Bochi formula for higher-dimensional pseudo-unitary and Hermitian-symplectic-cocycles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2015'
...
---
_id: '1504'
abstract:
- lang: eng
  text: Let Q = (Q1, . . . , Qn) be a random vector drawn from the uniform distribution
    on the set of all n! permutations of {1, 2, . . . , n}. Let Z = (Z1, . . . , Zn),
    where Zj is the mean zero variance one random variable obtained by centralizing
    and normalizing Qj , j = 1, . . . , n. Assume that Xi , i = 1, . . . ,p are i.i.d.
    copies of 1/√ p Z and X = Xp,n is the p × n random matrix with Xi as its ith row.
    Then Sn = XX is called the p × n Spearman's rank correlation matrix which can
    be regarded as a high dimensional extension of the classical nonparametric statistic
    Spearman's rank correlation coefficient between two independent random variables.
    In this paper, we establish a CLT for the linear spectral statistics of this nonparametric
    random matrix model in the scenario of high dimension, namely, p = p(n) and p/n→c
    ∈ (0,∞) as n→∞.We propose a novel evaluation scheme to estimate the core quantity
    in Anderson and Zeitouni's cumulant method in [Ann. Statist. 36 (2008) 2553-2576]
    to bypass the so-called joint cumulant summability. In addition, we raise a two-step
    comparison approach to obtain the explicit formulae for the mean and covariance
    functions in the CLT. Relying on this CLT, we then construct a distribution-free
    statistic to test complete independence for components of random vectors. Owing
    to the nonparametric property, we can use this test on generally distributed random
    variables including the heavy-tailed ones.
author:
- first_name: Zhigang
  full_name: Bao, Zhigang
  id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
  last_name: Bao
  orcid: 0000-0003-3036-1475
- first_name: Liang
  full_name: Lin, Liang
  last_name: Lin
- first_name: Guangming
  full_name: Pan, Guangming
  last_name: Pan
- first_name: Wang
  full_name: Zhou, Wang
  last_name: Zhou
citation:
  ama: Bao Z, Lin L, Pan G, Zhou W. Spectral statistics of large dimensional spearman
    s rank correlation matrix and its application. <i>Annals of Statistics</i>. 2015;43(6):2588-2623.
    doi:<a href="https://doi.org/10.1214/15-AOS1353">10.1214/15-AOS1353</a>
  apa: Bao, Z., Lin, L., Pan, G., &#38; Zhou, W. (2015). Spectral statistics of large
    dimensional spearman s rank correlation matrix and its application. <i>Annals
    of Statistics</i>. Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/15-AOS1353">https://doi.org/10.1214/15-AOS1353</a>
  chicago: Bao, Zhigang, Liang Lin, Guangming Pan, and Wang Zhou. “Spectral Statistics
    of Large Dimensional Spearman s Rank Correlation Matrix and Its Application.”
    <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2015. <a href="https://doi.org/10.1214/15-AOS1353">https://doi.org/10.1214/15-AOS1353</a>.
  ieee: Z. Bao, L. Lin, G. Pan, and W. Zhou, “Spectral statistics of large dimensional
    spearman s rank correlation matrix and its application,” <i>Annals of Statistics</i>,
    vol. 43, no. 6. Institute of Mathematical Statistics, pp. 2588–2623, 2015.
  ista: Bao Z, Lin L, Pan G, Zhou W. 2015. Spectral statistics of large dimensional
    spearman s rank correlation matrix and its application. Annals of Statistics.
    43(6), 2588–2623.
  mla: Bao, Zhigang, et al. “Spectral Statistics of Large Dimensional Spearman s Rank
    Correlation Matrix and Its Application.” <i>Annals of Statistics</i>, vol. 43,
    no. 6, Institute of Mathematical Statistics, 2015, pp. 2588–623, doi:<a href="https://doi.org/10.1214/15-AOS1353">10.1214/15-AOS1353</a>.
  short: Z. Bao, L. Lin, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 2588–2623.
date_created: 2018-12-11T11:52:24Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
doi: 10.1214/15-AOS1353
extern: '1'
intvolume: '        43'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1312.5119
month: '12'
oa: 1
oa_version: Published Version
page: 2588 - 2623
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5674'
quality_controlled: '1'
status: public
title: Spectral statistics of large dimensional spearman s rank correlation matrix
  and its application
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1505'
abstract:
- lang: eng
  text: This paper is aimed at deriving the universality of the largest eigenvalue
    of a class of high-dimensional real or complex sample covariance matrices of the
    form W N =Σ 1/2XX∗Σ 1/2 . Here, X = (xij )M,N is an M× N random matrix with independent
    entries xij , 1 ≤ i M,≤ 1 ≤ j ≤ N such that Exij = 0, E|xij |2 = 1/N . On dimensionality,
    we assume that M = M(N) and N/M → d ε (0, ∞) as N ∞→. For a class of general deterministic
    positive-definite M × M matrices Σ , under some additional assumptions on the
    distribution of xij 's, we show that the limiting behavior of the largest eigenvalue
    of W N is universal, via pursuing a Green function comparison strategy raised
    in [Probab. Theory Related Fields 154 (2012) 341-407, Adv. Math. 229 (2012) 1435-1515]
    by Erd″os, Yau and Yin for Wigner matrices and extended by Pillai and Yin [Ann.
    Appl. Probab. 24 (2014) 935-1001] to sample covariance matrices in the null case
    (&amp;Epsi = I ). Consequently, in the standard complex case (Ex2 ij = 0), combing
    this universality property and the results known for Gaussian matrices obtained
    by El Karoui in [Ann. Probab. 35 (2007) 663-714] (nonsingular case) and Onatski
    in [Ann. Appl. Probab. 18 (2008) 470-490] (singular case), we show that after
    an appropriate normalization the largest eigenvalue of W N converges weakly to
    the type 2 Tracy-Widom distribution TW2 . Moreover, in the real case, we show
    that whenΣ is spiked with a fixed number of subcritical spikes, the type 1 Tracy-Widom
    limit TW1 holds for the normalized largest eigenvalue of W N , which extends a
    result of Féral and Péché in [J. Math. Phys. 50 (2009) 073302] to the scenario
    of nondiagonal Σ and more generally distributed X . In summary, we establish the
    Tracy-Widom type universality for the largest eigenvalue of generally distributed
    sample covariance matrices under quite light assumptions on &amp;Sigma . Applications
    of these limiting results to statistical signal detection and structure recognition
    of separable covariance matrices are also discussed.
acknowledgement: "B.Z. was supported  in  part  by  NSFC  Grant  11071213,  ZJNSF
  \ Grant  R6090034  and  SRFDP  Grant 20100101110001. P.G. was supported in part
  by the Ministry of Education, Singapore, under Grant ARC 14/11. Z.W. was supported
  \ in  part  by  the  Ministry  of  Education,  Singapore,  under  Grant  ARC  14/11,
  \ and  by a Grant R-155-000-131-112 at the National University of Singapore\r\n"
author:
- first_name: Zhigang
  full_name: Bao, Zhigang
  id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
  last_name: Bao
  orcid: 0000-0003-3036-1475
- first_name: Guangming
  full_name: Pan, Guangming
  last_name: Pan
- first_name: Wang
  full_name: Zhou, Wang
  last_name: Zhou
citation:
  ama: Bao Z, Pan G, Zhou W. Universality for the largest eigenvalue of sample covariance
    matrices with general population. <i>Annals of Statistics</i>. 2015;43(1):382-421.
    doi:<a href="https://doi.org/10.1214/14-AOS1281">10.1214/14-AOS1281</a>
  apa: Bao, Z., Pan, G., &#38; Zhou, W. (2015). Universality for the largest eigenvalue
    of sample covariance matrices with general population. <i>Annals of Statistics</i>.
    Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/14-AOS1281">https://doi.org/10.1214/14-AOS1281</a>
  chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “Universality for the Largest
    Eigenvalue of Sample Covariance Matrices with General Population.” <i>Annals of
    Statistics</i>. Institute of Mathematical Statistics, 2015. <a href="https://doi.org/10.1214/14-AOS1281">https://doi.org/10.1214/14-AOS1281</a>.
  ieee: Z. Bao, G. Pan, and W. Zhou, “Universality for the largest eigenvalue of sample
    covariance matrices with general population,” <i>Annals of Statistics</i>, vol.
    43, no. 1. Institute of Mathematical Statistics, pp. 382–421, 2015.
  ista: Bao Z, Pan G, Zhou W. 2015. Universality for the largest eigenvalue of sample
    covariance matrices with general population. Annals of Statistics. 43(1), 382–421.
  mla: Bao, Zhigang, et al. “Universality for the Largest Eigenvalue of Sample Covariance
    Matrices with General Population.” <i>Annals of Statistics</i>, vol. 43, no. 1,
    Institute of Mathematical Statistics, 2015, pp. 382–421, doi:<a href="https://doi.org/10.1214/14-AOS1281">10.1214/14-AOS1281</a>.
  short: Z. Bao, G. Pan, W. Zhou, Annals of Statistics 43 (2015) 382–421.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-02-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.1214/14-AOS1281
intvolume: '        43'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1304.5690
month: '02'
oa: 1
oa_version: Preprint
page: 382 - 421
publication: Annals of Statistics
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5672'
quality_controlled: '1'
status: public
title: Universality for the largest eigenvalue of sample covariance matrices with
  general population
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2015'
...
---
_id: '1506'
abstract:
- lang: eng
  text: Consider the square random matrix An = (aij)n,n, where {aij:= a(n)ij , i,
    j = 1, . . . , n} is a collection of independent real random variables with means
    zero and variances one. Under the additional moment condition supn max1≤i,j ≤n
    Ea4ij &lt;∞, we prove Girko's logarithmic law of det An in the sense that as n→∞
    log | detAn| ? (1/2) log(n-1)! d/→√(1/2) log n N(0, 1).
author:
- first_name: Zhigang
  full_name: Bao, Zhigang
  id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
  last_name: Bao
  orcid: 0000-0003-3036-1475
- first_name: Guangming
  full_name: Pan, Guangming
  last_name: Pan
- first_name: Wang
  full_name: Zhou, Wang
  last_name: Zhou
citation:
  ama: Bao Z, Pan G, Zhou W. The logarithmic law of random determinant. <i>Bernoulli</i>.
    2015;21(3):1600-1628. doi:<a href="https://doi.org/10.3150/14-BEJ615">10.3150/14-BEJ615</a>
  apa: Bao, Z., Pan, G., &#38; Zhou, W. (2015). The logarithmic law of random determinant.
    <i>Bernoulli</i>. Bernoulli Society for Mathematical Statistics and Probability.
    <a href="https://doi.org/10.3150/14-BEJ615">https://doi.org/10.3150/14-BEJ615</a>
  chicago: Bao, Zhigang, Guangming Pan, and Wang Zhou. “The Logarithmic Law of Random
    Determinant.” <i>Bernoulli</i>. Bernoulli Society for Mathematical Statistics
    and Probability, 2015. <a href="https://doi.org/10.3150/14-BEJ615">https://doi.org/10.3150/14-BEJ615</a>.
  ieee: Z. Bao, G. Pan, and W. Zhou, “The logarithmic law of random determinant,”
    <i>Bernoulli</i>, vol. 21, no. 3. Bernoulli Society for Mathematical Statistics
    and Probability, pp. 1600–1628, 2015.
  ista: Bao Z, Pan G, Zhou W. 2015. The logarithmic law of random determinant. Bernoulli.
    21(3), 1600–1628.
  mla: Bao, Zhigang, et al. “The Logarithmic Law of Random Determinant.” <i>Bernoulli</i>,
    vol. 21, no. 3, Bernoulli Society for Mathematical Statistics and Probability,
    2015, pp. 1600–28, doi:<a href="https://doi.org/10.3150/14-BEJ615">10.3150/14-BEJ615</a>.
  short: Z. Bao, G. Pan, W. Zhou, Bernoulli 21 (2015) 1600–1628.
date_created: 2018-12-11T11:52:25Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:14Z
day: '01'
department:
- _id: LaEr
doi: 10.3150/14-BEJ615
intvolume: '        21'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1208.5823
month: '08'
oa: 1
oa_version: Preprint
page: 1600 - 1628
publication: Bernoulli
publication_status: published
publisher: Bernoulli Society for Mathematical Statistics and Probability
publist_id: '5671'
quality_controlled: '1'
status: public
title: The logarithmic law of random determinant
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2015'
...
---
_id: '1508'
abstract:
- lang: eng
  text: We consider generalized Wigner ensembles and general β-ensembles with analytic
    potentials for any β ≥ 1. The recent universality results in particular assert
    that the local averages of consecutive eigenvalue gaps in the bulk of the spectrum
    are universal in the sense that they coincide with those of the corresponding
    Gaussian β-ensembles. In this article, we show that local averaging is not necessary
    for this result, i.e. we prove that the single gap distributions in the bulk are
    universal. In fact, with an additional step, our result can be extended to any
    C4(ℝ) potential.
author:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Horng
  full_name: Yau, Horng
  last_name: Yau
citation:
  ama: Erdös L, Yau H. Gap universality of generalized Wigner and β ensembles. <i>Journal
    of the European Mathematical Society</i>. 2015;17(8):1927-2036. doi:<a href="https://doi.org/10.4171/JEMS/548">10.4171/JEMS/548</a>
  apa: Erdös, L., &#38; Yau, H. (2015). Gap universality of generalized Wigner and
    β ensembles. <i>Journal of the European Mathematical Society</i>. European Mathematical
    Society. <a href="https://doi.org/10.4171/JEMS/548">https://doi.org/10.4171/JEMS/548</a>
  chicago: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and
    β Ensembles.” <i>Journal of the European Mathematical Society</i>. European Mathematical
    Society, 2015. <a href="https://doi.org/10.4171/JEMS/548">https://doi.org/10.4171/JEMS/548</a>.
  ieee: L. Erdös and H. Yau, “Gap universality of generalized Wigner and β ensembles,”
    <i>Journal of the European Mathematical Society</i>, vol. 17, no. 8. European
    Mathematical Society, pp. 1927–2036, 2015.
  ista: Erdös L, Yau H. 2015. Gap universality of generalized Wigner and β ensembles.
    Journal of the European Mathematical Society. 17(8), 1927–2036.
  mla: Erdös, László, and Horng Yau. “Gap Universality of Generalized Wigner and β
    Ensembles.” <i>Journal of the European Mathematical Society</i>, vol. 17, no.
    8, European Mathematical Society, 2015, pp. 1927–2036, doi:<a href="https://doi.org/10.4171/JEMS/548">10.4171/JEMS/548</a>.
  short: L. Erdös, H. Yau, Journal of the European Mathematical Society 17 (2015)
    1927–2036.
date_created: 2018-12-11T11:52:26Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:15Z
day: '01'
department:
- _id: LaEr
doi: 10.4171/JEMS/548
intvolume: '        17'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1211.3786
month: '08'
oa: 1
oa_version: Preprint
page: 1927 - 2036
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society
publist_id: '5669'
quality_controlled: '1'
scopus_import: 1
status: public
title: Gap universality of generalized Wigner and β ensembles
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2015'
...
---
_id: '1509'
abstract:
- lang: eng
  text: The Auxin Binding Protein1 (ABP1) has been identified based on its ability
    to bind auxin with high affinity and studied for a long time as a prime candidate
    for the extracellular auxin receptor responsible for mediating in particular the
    fast non-transcriptional auxin responses. However, the contradiction between the
    embryo-lethal phenotypes of the originally described Arabidopsis T-DNA insertional
    knock-out alleles (abp1-1 and abp1-1s) and the wild type-like phenotypes of other
    recently described loss-of-function alleles (abp1-c1 and abp1-TD1) questions the
    biological importance of ABP1 and relevance of the previous genetic studies. Here
    we show that there is no hidden copy of the ABP1 gene in the Arabidopsis genome
    but the embryo-lethal phenotypes of abp1-1 and abp1-1s alleles are very similar
    to the knock-out phenotypes of the neighboring gene, BELAYA SMERT (BSM). Furthermore,
    the allelic complementation test between bsm and abp1 alleles shows that the embryo-lethality
    in the abp1-1 and abp1-1s alleles is caused by the off-target disruption of the
    BSM locus by the T-DNA insertions. This clarifies the controversy of different
    phenotypes among published abp1 knock-out alleles and asks for reflections on
    the developmental role of ABP1.
acknowledgement: "This work was supported by ERC Independent Research grant (ERC-2011-StG-20101109-PSDP
  to JF). JM internship was supported by the grant “Action Austria – Slovakia”.\r\nData
  associated with the article are available under the terms of the Creative Commons
  Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication). \r\n\r\nData
  availability: \r\nF1000Research: Dataset 1. Dataset 1, 10.5256/f1000research.7143.d104552\r\n\r\nF1000Research:
  Dataset 2. Dataset 2, 10.5256/f1000research.7143.d104553\r\n\r\nF1000Research: Dataset
  3. Dataset 3, 10.5256/f1000research.7143.d104554"
article_processing_charge: No
author:
- first_name: Jaroslav
  full_name: Michalko, Jaroslav
  id: 483727CA-F248-11E8-B48F-1D18A9856A87
  last_name: Michalko
- first_name: Marta
  full_name: Dravecka, Marta
  id: 4342E402-F248-11E8-B48F-1D18A9856A87
  last_name: Dravecka
  orcid: 0000-0002-2519-8004
- first_name: Tobias
  full_name: Bollenbach, Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Michalko J, Lukacisinova M, Bollenbach MT, Friml J. Embryo-lethal phenotypes
    in early abp1 mutants are due to disruption of the neighboring BSM gene. <i>F1000
    Research </i>. 2015;4. doi:<a href="https://doi.org/10.12688/f1000research.7143.1">10.12688/f1000research.7143.1</a>
  apa: Michalko, J., Lukacisinova, M., Bollenbach, M. T., &#38; Friml, J. (2015).
    Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the neighboring
    BSM gene. <i>F1000 Research </i>. F1000 Research. <a href="https://doi.org/10.12688/f1000research.7143.1">https://doi.org/10.12688/f1000research.7143.1</a>
  chicago: Michalko, Jaroslav, Marta Lukacisinova, Mark Tobias Bollenbach, and Jiří
    Friml. “Embryo-Lethal Phenotypes in Early Abp1 Mutants Are Due to Disruption of
    the Neighboring BSM Gene.” <i>F1000 Research </i>. F1000 Research, 2015. <a href="https://doi.org/10.12688/f1000research.7143.1">https://doi.org/10.12688/f1000research.7143.1</a>.
  ieee: J. Michalko, M. Lukacisinova, M. T. Bollenbach, and J. Friml, “Embryo-lethal
    phenotypes in early abp1 mutants are due to disruption of the neighboring BSM
    gene,” <i>F1000 Research </i>, vol. 4. F1000 Research, 2015.
  ista: Michalko J, Lukacisinova M, Bollenbach MT, Friml J. 2015. Embryo-lethal phenotypes
    in early abp1 mutants are due to disruption of the neighboring BSM gene. F1000
    Research . 4.
  mla: Michalko, Jaroslav, et al. “Embryo-Lethal Phenotypes in Early Abp1 Mutants
    Are Due to Disruption of the Neighboring BSM Gene.” <i>F1000 Research </i>, vol.
    4, F1000 Research, 2015, doi:<a href="https://doi.org/10.12688/f1000research.7143.1">10.12688/f1000research.7143.1</a>.
  short: J. Michalko, M. Lukacisinova, M.T. Bollenbach, J. Friml, F1000 Research  4
    (2015).
date_created: 2018-12-11T11:52:26Z
date_published: 2015-10-01T00:00:00Z
date_updated: 2025-05-07T11:12:30Z
day: '01'
ddc:
- '570'
department:
- _id: JiFr
- _id: ToBo
doi: 10.12688/f1000research.7143.1
ec_funded: 1
file:
- access_level: open_access
  checksum: 8beae5cbe988e1060265ae7de2ee8306
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:12Z
  date_updated: 2020-07-14T12:44:59Z
  file_id: '5198'
  file_name: IST-2016-497-v1+1_10.12688_f1000research.7143.1_20151102.pdf
  file_size: 4414248
  relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
intvolume: '         4'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: 'F1000 Research '
publication_status: published
publisher: F1000 Research
publist_id: '5668'
pubrep_id: '497'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Embryo-lethal phenotypes in early abp1 mutants are due to disruption of the
  neighboring BSM gene
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2015'
...
---
_id: '1510'
abstract:
- lang: eng
  text: 'The concept of well group in a special but important case captures homological
    properties of the zero set of a continuous map f from K to R^n on a compact space
    K that are invariant with respect to perturbations of f. The perturbations are
    arbitrary continuous maps within L_infty distance r from f for a given r &gt;
    0. The main drawback of the approach is that the computability of well groups
    was shown only when dim K = n or n = 1. Our contribution to the theory of well
    groups is twofold: on the one hand we improve on the computability issue, but
    on the other hand we present a range of examples where the well groups are incomplete
    invariants, that is, fail to capture certain important robust properties of the
    zero set. For the first part, we identify a computable subgroup of the well group
    that is obtained by cap product with the pullback of the orientation of R^n by
    f. In other words, well groups can be algorithmically approximated from below.
    When f is smooth and dim K &lt; 2n-2, our approximation of the (dim K-n)th well
    group is exact. For the second part, we find examples of maps f, f'' from K to
    R^n with all well groups isomorphic but whose perturbations have different zero
    sets. We discuss on a possible replacement of the well groups of vector valued
    maps by an invariant of a better descriptive power and computability status. '
alternative_title:
- LIPIcs
author:
- first_name: Peter
  full_name: Franek, Peter
  id: 473294AE-F248-11E8-B48F-1D18A9856A87
  last_name: Franek
- first_name: Marek
  full_name: Krcál, Marek
  id: 33E21118-F248-11E8-B48F-1D18A9856A87
  last_name: Krcál
citation:
  ama: 'Franek P, Krcál M. On computability and triviality of well groups. In: Vol
    34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:842-856. doi:<a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.842">10.4230/LIPIcs.SOCG.2015.842</a>'
  apa: 'Franek, P., &#38; Krcál, M. (2015). On computability and triviality of well
    groups (Vol. 34, pp. 842–856). Presented at the SoCG: Symposium on Computational
    Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
    <a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.842">https://doi.org/10.4230/LIPIcs.SOCG.2015.842</a>'
  chicago: Franek, Peter, and Marek Krcál. “On Computability and Triviality of Well
    Groups,” 34:842–56. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015. <a
    href="https://doi.org/10.4230/LIPIcs.SOCG.2015.842">https://doi.org/10.4230/LIPIcs.SOCG.2015.842</a>.
  ieee: 'P. Franek and M. Krcál, “On computability and triviality of well groups,”
    presented at the SoCG: Symposium on Computational Geometry, Eindhoven, Netherlands,
    2015, vol. 34, pp. 842–856.'
  ista: 'Franek P, Krcál M. 2015. On computability and triviality of well groups.
    SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 842–856.'
  mla: Franek, Peter, and Marek Krcál. <i>On Computability and Triviality of Well
    Groups</i>. Vol. 34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015,
    pp. 842–56, doi:<a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.842">10.4230/LIPIcs.SOCG.2015.842</a>.
  short: P. Franek, M. Krcál, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2015, pp. 842–856.
conference:
  end_date: 2015-06-25
  location: Eindhoven, Netherlands
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2015-06-22
date_created: 2018-12-11T11:52:26Z
date_published: 2015-06-11T00:00:00Z
date_updated: 2023-02-21T17:02:57Z
day: '11'
ddc:
- '510'
department:
- _id: UlWa
- _id: HeEd
doi: 10.4230/LIPIcs.SOCG.2015.842
ec_funded: 1
file:
- access_level: open_access
  checksum: 49eb5021caafaabe5356c65b9c5f8c9c
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:19Z
  date_updated: 2020-07-14T12:44:59Z
  file_id: '5001'
  file_name: IST-2016-503-v1+1_32.pdf
  file_size: 623563
  relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
intvolume: '        34'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 842 - 856
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5667'
pubrep_id: '503'
quality_controlled: '1'
related_material:
  record:
  - id: '1408'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: On computability and triviality of well groups
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2015'
...
---
_id: '1511'
abstract:
- lang: eng
  text: 'The fact that the complete graph K_5 does not embed in the plane has been
    generalized in two independent directions. On the one hand, the solution of the
    classical Heawood problem for graphs on surfaces established that the complete
    graph K_n embeds in a closed surface M if and only if (n-3)(n-4) is at most 6b_1(M),
    where b_1(M) is the first Z_2-Betti number of M. On the other hand, Van Kampen
    and Flores proved that the k-skeleton of the n-dimensional simplex (the higher-dimensional
    analogue of K_{n+1}) embeds in R^{2k} if and only if n is less or equal to 2k+2.
    Two decades ago, Kuhnel conjectured that the k-skeleton of the n-simplex embeds
    in a compact, (k-1)-connected 2k-manifold with kth Z_2-Betti number b_k only if
    the following generalized Heawood inequality holds: binom{n-k-1}{k+1} is at most
    binom{2k+1}{k+1} b_k. This is a common generalization of the case of graphs on
    surfaces as well as the Van Kampen--Flores theorem. In the spirit of Kuhnel''s
    conjecture, we prove that if the k-skeleton of the n-simplex embeds in a 2k-manifold
    with kth Z_2-Betti number b_k, then n is at most 2b_k binom{2k+2}{k} + 2k + 5.
    This bound is weaker than the generalized Heawood inequality, but does not require
    the assumption that M is (k-1)-connected. Our proof uses a result of Volovikov
    about maps that satisfy a certain homological triviality condition.'
acknowledgement: "The work by Z. P. was partially supported by the Charles University
  Grant SVV-2014-260103. The\r\nwork by Z. P. and M. T. was partially supported by
  the project CE-ITI (GACR P202/12/G061) of\r\nthe Czech Science Foundation and by
  the ERC Advanced Grant No. 267165. Part of the research\r\nwork of M. T. was conducted
  at IST Austria, supported by an IST Fellowship. The work by U.W.\r\nwas partially
  supported by the Swiss National Science Foundation (grants SNSF-200020-138230 and\r\nSNSF-PP00P2-138948)."
alternative_title:
- LIPIcs
author:
- first_name: Xavier
  full_name: Goaoc, Xavier
  last_name: Goaoc
- first_name: Isaac
  full_name: Mabillard, Isaac
  id: 32BF9DAA-F248-11E8-B48F-1D18A9856A87
  last_name: Mabillard
- first_name: Pavel
  full_name: Paták, Pavel
  last_name: Paták
- first_name: Zuzana
  full_name: Patakova, Zuzana
  id: 48B57058-F248-11E8-B48F-1D18A9856A87
  last_name: Patakova
  orcid: 0000-0002-3975-1683
- first_name: Martin
  full_name: Tancer, Martin
  id: 38AC689C-F248-11E8-B48F-1D18A9856A87
  last_name: Tancer
  orcid: 0000-0002-1191-6714
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
citation:
  ama: 'Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. On generalized
    Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
    result. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2015:476-490.
    doi:<a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.476">10.4230/LIPIcs.SOCG.2015.476</a>'
  apa: 'Goaoc, X., Mabillard, I., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner,
    U. (2015). On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type
    nonembeddability result (Vol. 34, pp. 476–490). Presented at the SoCG: Symposium
    on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.476">https://doi.org/10.4230/LIPIcs.SOCG.2015.476</a>'
  chicago: 'Goaoc, Xavier, Isaac Mabillard, Pavel Paták, Zuzana Patakova, Martin Tancer,
    and Uli Wagner. “On Generalized Heawood Inequalities for Manifolds: A Van Kampen–Flores-Type
    Nonembeddability Result,” 34:476–90. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2015. <a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.476">https://doi.org/10.4230/LIPIcs.SOCG.2015.476</a>.'
  ieee: 'X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, and U. Wagner,
    “On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
    result,” presented at the SoCG: Symposium on Computational Geometry, Eindhoven,
    Netherlands, 2015, vol. 34, pp. 476–490.'
  ista: 'Goaoc X, Mabillard I, Paták P, Patakova Z, Tancer M, Wagner U. 2015. On generalized
    Heawood inequalities for manifolds: A Van Kampen–Flores-type nonembeddability
    result. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34, 476–490.'
  mla: 'Goaoc, Xavier, et al. <i>On Generalized Heawood Inequalities for Manifolds:
    A Van Kampen–Flores-Type Nonembeddability Result</i>. Vol. 34, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2015, pp. 476–90, doi:<a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.476">10.4230/LIPIcs.SOCG.2015.476</a>.'
  short: X. Goaoc, I. Mabillard, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 476–490.
conference:
  end_date: 2015-06-25
  location: Eindhoven, Netherlands
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2015-06-22
date_created: 2018-12-11T11:52:27Z
date_published: 2015-06-11T00:00:00Z
date_updated: 2023-02-23T12:38:00Z
day: '11'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SOCG.2015.476
ec_funded: 1
file:
- access_level: open_access
  checksum: 0945811875351796324189312ca29e9e
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:18Z
  date_updated: 2020-07-14T12:44:59Z
  file_id: '4871'
  file_name: IST-2016-502-v1+1_42.pdf
  file_size: 636735
  relation: main_file
file_date_updated: 2020-07-14T12:44:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 476 - 490
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5666'
pubrep_id: '502'
quality_controlled: '1'
related_material:
  record:
  - id: '610'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: 'On generalized Heawood inequalities for manifolds: A Van Kampen–Flores-type
  nonembeddability result'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: '34 '
year: '2015'
...
---
_id: '1512'
abstract:
- lang: eng
  text: 'We show that very weak topological assumptions are enough to ensure the existence
    of a Helly-type theorem. More precisely, we show that for any non-negative integers
    b and d there exists an integer h(b,d) such that the following holds. If F is
    a finite family of subsets of R^d such that the ith reduced Betti number (with
    Z_2 coefficients in singular homology) of the intersection of any proper subfamily
    G of F is at most b for every non-negative integer i less or equal to (d-1)/2,
    then F has Helly number at most h(b,d). These topological conditions are sharp:
    not controlling any of these first Betti numbers allow for families with unbounded
    Helly number. Our proofs combine homological non-embeddability results with a
    Ramsey-based approach to build, given an arbitrary simplicial complex K, some
    well-behaved chain map from C_*(K) to C_*(R^d). Both techniques are of independent
    interest.'
acknowledgement: "PP, ZP and MT were partially supported by the Charles University
  Grant GAUK 421511. ZP was\r\npartially supported by the Charles University Grant
  SVV-2014-260103. ZP and MT were partially\r\nsupported by the ERC Advanced Grant
  No. 267165 and by the project CE-ITI (GACR P202/12/G061)\r\nof the Czech Science
  Foundation. UW was partially supported by the Swiss National Science Foundation\r\n(grants
  SNSF-200020-138230 and SNSF-PP00P2-138948). Part of this work was done when XG was
  affiliated with INRIA Nancy Grand-Est and when MT was affiliated with Institutionen
  för matematik, Kungliga Tekniska Högskolan, then IST Austria."
alternative_title:
- LIPIcs
article_processing_charge: No
author:
- first_name: Xavier
  full_name: Goaoc, Xavier
  last_name: Goaoc
- first_name: Pavel
  full_name: Paták, Pavel
  last_name: Paták
- first_name: Zuzana
  full_name: Patakova, Zuzana
  last_name: Patakova
  orcid: 0000-0002-3975-1683
- first_name: Martin
  full_name: Tancer, Martin
  last_name: Tancer
  orcid: 0000-0002-1191-6714
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
citation:
  ama: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. Bounding Helly numbers via
    Betti numbers. In: Vol 34. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2015:507-521. doi:<a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.507">10.4230/LIPIcs.SOCG.2015.507</a>'
  apa: 'Goaoc, X., Paták, P., Patakova, Z., Tancer, M., &#38; Wagner, U. (2015). Bounding
    Helly numbers via Betti numbers (Vol. 34, pp. 507–521). Presented at the SoCG:
    Symposium on Computational Geometry, Eindhoven, Netherlands: Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.507">https://doi.org/10.4230/LIPIcs.SOCG.2015.507</a>'
  chicago: Goaoc, Xavier, Pavel Paták, Zuzana Patakova, Martin Tancer, and Uli Wagner.
    “Bounding Helly Numbers via Betti Numbers,” 34:507–21. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2015. <a href="https://doi.org/10.4230/LIPIcs.SOCG.2015.507">https://doi.org/10.4230/LIPIcs.SOCG.2015.507</a>.
  ieee: 'X. Goaoc, P. Paták, Z. Patakova, M. Tancer, and U. Wagner, “Bounding Helly
    numbers via Betti numbers,” presented at the SoCG: Symposium on Computational
    Geometry, Eindhoven, Netherlands, 2015, vol. 34, pp. 507–521.'
  ista: 'Goaoc X, Paták P, Patakova Z, Tancer M, Wagner U. 2015. Bounding Helly numbers
    via Betti numbers. SoCG: Symposium on Computational Geometry, LIPIcs, vol. 34,
    507–521.'
  mla: Goaoc, Xavier, et al. <i>Bounding Helly Numbers via Betti Numbers</i>. Vol.
    34, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2015, pp. 507–21, doi:<a
    href="https://doi.org/10.4230/LIPIcs.SOCG.2015.507">10.4230/LIPIcs.SOCG.2015.507</a>.
  short: X. Goaoc, P. Paták, Z. Patakova, M. Tancer, U. Wagner, in:, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2015, pp. 507–521.
conference:
  end_date: 2015-06-25
  location: Eindhoven, Netherlands
  name: 'SoCG: Symposium on Computational Geometry'
  start_date: 2015-06-22
date_created: 2018-12-11T11:52:27Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2024-02-28T12:59:37Z
day: '01'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.4230/LIPIcs.SOCG.2015.507
file:
- access_level: open_access
  checksum: e6881df44d87fe0c2529c9f7b2724614
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:09Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4794'
  file_name: IST-2016-501-v1+1_46.pdf
  file_size: 633712
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        34'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 507 - 521
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '5665'
pubrep_id: '501'
quality_controlled: '1'
related_material:
  record:
  - id: '424'
    relation: later_version
    status: public
scopus_import: '1'
status: public
title: Bounding Helly numbers via Betti numbers
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2015'
...
---
_id: '1513'
abstract:
- lang: eng
  text: "Insects of the order Hemiptera (true bugs) use a wide range of mechanisms
    of sex determination, including genetic sex determination, paternal genome elimination,
    and haplodiploidy. Genetic sex determination, the prevalent mode, is generally
    controlled by a pair of XY sex chromosomes or by an XX/X0 system, but different
    configurations that include additional sex chromosomes are also present. Although
    this diversity of sex determining systems has been extensively studied at the
    cytogenetic level, only the X chromosome of the model pea aphid Acyrthosiphon
    pisum has been analyzed at the genomic level, and little is known about X chromosome
    biology in the rest of the order.\r\n\r\nIn this study, we take advantage of published
    DNA- and RNA-seq data from three additional Hemiptera species to perform a comparative
    analysis of the gene content and expression of the X chromosome throughout this
    clade. We find that, despite showing evidence of dosage compensation, the X chromosomes
    of these species show female-biased expression, and a deficit of male-biased genes,
    in direct contrast to the pea aphid X. We further detect an excess of shared gene
    content between these very distant species, suggesting that despite the diversity
    of sex determining systems, the same chromosomal element is used as the X throughout
    a large portion of the order. "
article_processing_charge: No
author:
- first_name: Arka
  full_name: Pal, Arka
  id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
  last_name: Pal
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: 'Pal A, Vicoso B. The X chromosome of hemipteran insects: Conservation, dosage
    compensation and sex-biased expression. <i>Genome Biology and Evolution</i>. 2015;7(12):3259-3268.
    doi:<a href="https://doi.org/10.1093/gbe/evv215">10.1093/gbe/evv215</a>'
  apa: 'Pal, A., &#38; Vicoso, B. (2015). The X chromosome of hemipteran insects:
    Conservation, dosage compensation and sex-biased expression. <i>Genome Biology
    and Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/gbe/evv215">https://doi.org/10.1093/gbe/evv215</a>'
  chicago: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects:
    Conservation, Dosage Compensation and Sex-Biased Expression.” <i>Genome Biology
    and Evolution</i>. Oxford University Press, 2015. <a href="https://doi.org/10.1093/gbe/evv215">https://doi.org/10.1093/gbe/evv215</a>.'
  ieee: 'A. Pal and B. Vicoso, “The X chromosome of hemipteran insects: Conservation,
    dosage compensation and sex-biased expression,” <i>Genome Biology and Evolution</i>,
    vol. 7, no. 12. Oxford University Press, pp. 3259–3268, 2015.'
  ista: 'Pal A, Vicoso B. 2015. The X chromosome of hemipteran insects: Conservation,
    dosage compensation and sex-biased expression. Genome Biology and Evolution. 7(12),
    3259–3268.'
  mla: 'Pal, Arka, and Beatriz Vicoso. “The X Chromosome of Hemipteran Insects: Conservation,
    Dosage Compensation and Sex-Biased Expression.” <i>Genome Biology and Evolution</i>,
    vol. 7, no. 12, Oxford University Press, 2015, pp. 3259–68, doi:<a href="https://doi.org/10.1093/gbe/evv215">10.1093/gbe/evv215</a>.'
  short: A. Pal, B. Vicoso, Genome Biology and Evolution 7 (2015) 3259–3268.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-12-01T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evv215
ec_funded: 1
file:
- access_level: open_access
  checksum: 2b56b8c2e2a1d4cc3c9cb8daba26dd9b
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:29Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '5284'
  file_name: IST-2016-496-v1+1_Genome_Biol_Evol-2015-Pal-3259-68.pdf
  file_size: 858027
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '         7'
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 3259 - 3268
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Genome Biology and Evolution
publication_status: published
publisher: Oxford University Press
publist_id: '5664'
pubrep_id: '496'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'The X chromosome of hemipteran insects: Conservation, dosage compensation
  and sex-biased expression'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2015'
...
---
_id: '1514'
abstract:
- lang: eng
  text: 'Endocannabinoids (eCBs) play key roles in brain function, acting as modulatory
    signals in synaptic transmission and plasticity. They are recognized as retrograde
    messengers that mediate long-term synaptic depression (LTD), but their ability
    to induce long-term potentiation (LTP) is poorly known. We show that eCBs induce
    the long-term enhancement of transmitter release at single hippocampal synapses
    through stimulation of astrocytes when coincident with postsynaptic activity.
    This LTP requires the coordinated activity of the 3 elements of the tripartite
    synapse: 1) eCB-evoked astrocyte calcium signal that stimulates glutamate release;
    2) postsynaptic nitric oxide production; and 3) activation of protein kinase C
    and presynaptic group I metabotropic glutamate receptors, whose location at presynaptic
    sites was confirmed by immunoelectron microscopy. Hence, while eCBs act as retrograde
    signals to depress homoneuronal synapses, they serve as lateral messengers to
    induce LTP in distant heteroneuronal synapses through stimulation of astrocytes.
    Therefore, eCBs can trigger LTP through stimulation of astrocyte-neuron signaling,
    revealing novel cellular mechanisms of eCB effects on synaptic plasticity.'
acknowledgement: |-
  This work was supported by grants from Ministerio de Economia y Competitividad, Spain (MINECO; BFU2010-15832), European Union (HEALTH-F2-2007-202167), and Cajal Blue Brain to A.A. Grants from Spain (MINECO; BFU-2009-08404 and
  CSD2008-00005) to R.L. Grants from Spain (MINECO; Consolider, CSD2010-00045; Ramón y Cajal Program, RYC-2012-12014; and BFU2013-47265) to G.P. We thank Dr Atsu Aiba (Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo) for the donation of the mGluR1b rescue mice.
author:
- first_name: Marta
  full_name: Gómez-Gonzalo, Marta
  last_name: Gómez Gonzalo
- first_name: Marta
  full_name: Navarrete, Marta
  last_name: Navarrete
- first_name: Gertrudis
  full_name: Perea, Gertrudis
  last_name: Perea
- first_name: Ana
  full_name: Covelo, Ana
  last_name: Covelo
- first_name: Mario
  full_name: Martín-Fernández, Mario
  last_name: Martín Fernández
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Rafael
  full_name: Luján, Rafael
  last_name: Luján
- first_name: Alfonso
  full_name: Araque, Alfonso
  last_name: Araque
citation:
  ama: Gómez Gonzalo M, Navarrete M, Perea G, et al. Endocannabinoids induce lateral
    long term potentiation of transmitter release by stimulation of gliotransmission.
    <i>Cerebral Cortex</i>. 2015;25(10):3699-3712. doi:<a href="https://doi.org/10.1093/cercor/bhu231">10.1093/cercor/bhu231</a>
  apa: Gómez Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín Fernández,
    M., Shigemoto, R., … Araque, A. (2015). Endocannabinoids induce lateral long term
    potentiation of transmitter release by stimulation of gliotransmission. <i>Cerebral
    Cortex</i>. Oxford University Press. <a href="https://doi.org/10.1093/cercor/bhu231">https://doi.org/10.1093/cercor/bhu231</a>
  chicago: Gómez Gonzalo, Marta, Marta Navarrete, Gertrudis Perea, Ana Covelo, Mario
    Martín Fernández, Ryuichi Shigemoto, Rafael Luján, and Alfonso Araque. “Endocannabinoids
    Induce Lateral Long Term Potentiation of Transmitter Release by Stimulation of
    Gliotransmission.” <i>Cerebral Cortex</i>. Oxford University Press, 2015. <a href="https://doi.org/10.1093/cercor/bhu231">https://doi.org/10.1093/cercor/bhu231</a>.
  ieee: M. Gómez Gonzalo <i>et al.</i>, “Endocannabinoids induce lateral long term
    potentiation of transmitter release by stimulation of gliotransmission,” <i>Cerebral
    Cortex</i>, vol. 25, no. 10. Oxford University Press, pp. 3699–3712, 2015.
  ista: Gómez Gonzalo M, Navarrete M, Perea G, Covelo A, Martín Fernández M, Shigemoto
    R, Luján R, Araque A. 2015. Endocannabinoids induce lateral long term potentiation
    of transmitter release by stimulation of gliotransmission. Cerebral Cortex. 25(10),
    3699–3712.
  mla: Gómez Gonzalo, Marta, et al. “Endocannabinoids Induce Lateral Long Term Potentiation
    of Transmitter Release by Stimulation of Gliotransmission.” <i>Cerebral Cortex</i>,
    vol. 25, no. 10, Oxford University Press, 2015, pp. 3699–712, doi:<a href="https://doi.org/10.1093/cercor/bhu231">10.1093/cercor/bhu231</a>.
  short: M. Gómez Gonzalo, M. Navarrete, G. Perea, A. Covelo, M. Martín Fernández,
    R. Shigemoto, R. Luján, A. Araque, Cerebral Cortex 25 (2015) 3699–3712.
date_created: 2018-12-11T11:52:27Z
date_published: 2015-10-10T00:00:00Z
date_updated: 2021-01-12T06:51:18Z
day: '10'
doi: 10.1093/cercor/bhu231
extern: 1
intvolume: '        25'
issue: '10'
month: '10'
page: 3699 - 3712
publication: Cerebral Cortex
publication_status: published
publisher: Oxford University Press
publist_id: '5663'
quality_controlled: 0
status: public
title: Endocannabinoids induce lateral long term potentiation of transmitter release
  by stimulation of gliotransmission
type: journal_article
volume: 25
year: '2015'
...
---
_id: '1515'
abstract:
- lang: eng
  text: Type 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in different
    forms of synaptic plasticity in the cerebellar cortex, e.g. long-term depression
    at glutamatergic synapses and rebound potentiation at GABAergic synapses. These
    various forms of plasticity might depend on the subsynaptic arrangement of the
    receptor in Purkinje cells that can be regulated by protein-protein interactions.
    This study investigated, by means of the freeze-fracture replica immunogold labelling
    method, the subcellular localization of mGlu1 receptors in the rodent cerebellum
    and whether Homer proteins regulate their subsynaptic distribution. We observed
    a widespread extrasynaptic localization of mGlu1 receptors and confirmed their
    peri-synaptic enrichment at glutamatergic synapses. Conversely, we detected mGlu1
    receptors within the main body of GABAergic synapses onto Purkinje cell dendrites.
    Although Homer proteins are known to interact with the mGlu1 receptor C-terminus,
    we could not detect Homer3, the most abundant Homer protein in the cerebellar
    cortex, at GABAergic synapses by pre-embedding and post-embedding immunoelectron
    microscopy. We then hypothesized a critical role for Homer proteins in the peri-junctional
    localization of mGlu1 receptors at glutamatergic synapses. To disrupt Homer-associated
    protein complexes, mice were tail-vein injected with the membrane-permeable dominant-negative
    TAT-Homer1a. Freeze-fracture replica immunogold labelling analysis showed no significant
    alteration in the mGlu1 receptor distribution pattern at parallel fibre-Purkinje
    cell synapses, suggesting that other scaffolding proteins are involved in the
    peri-synaptic confinement. The identification of interactors that regulate the
    subsynaptic localization of the mGlu1 receptor at neurochemically distinct synapses
    may offer new insight into its trafficking and intracellular signalling.
acknowledgement: This work was supported by the Austrian Science Fund (FWF) (project
  W012060-10 to F.F.), The Japan Society for the Promotion of Science (JSPS) (to R.S.)
  and Agence Nationale de la Recherche (ANR-11-BSV4-018-03, DELTAPLAN), Région Languedoc-Roussillon
  (Chercheur d’Avenir) (to J.P.). The authors thank S. Schönherr for excellent technical
  support and Dr Furuichi for kindly providing anti-Homer3 antibodies.
author:
- first_name: Mahnaz
  full_name: Mansouri, Mahnaz
  last_name: Mansouri
- first_name: Yu
  full_name: Kasugai, Yu
  last_name: Kasugai
- first_name: Yugo
  full_name: Fukazawa, Yugo
  last_name: Fukazawa
- first_name: Federica
  full_name: Bertaso, Federica
  last_name: Bertaso
- first_name: Fabrice
  full_name: Raynaud, Fabrice
  last_name: Raynaud
- first_name: Julie
  full_name: Perroy, Julie
  last_name: Perroy
- first_name: Laurent
  full_name: Fagni, Laurent
  last_name: Fagni
- first_name: Walter
  full_name: Walter Kaufmann
  id: 3F99E422-F248-11E8-B48F-1D18A9856A87
  last_name: Kaufmann
  orcid: 0000-0001-9735-5315
- first_name: Masahiko
  full_name: Watanabe, Masahiko
  last_name: Watanabe
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Francesco
  full_name: Ferraguti, Francesco
  last_name: Ferraguti
citation:
  ama: Mansouri M, Kasugai Y, Fukazawa Y, et al. Distinct subsynaptic localization
    of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
    in the rodent cerebellar cortex. <i>European Journal of Neuroscience</i>. 2015;41(2):157-167.
    doi:<a href="https://doi.org/10.1111/ejn.12779">10.1111/ejn.12779</a>
  apa: Mansouri, M., Kasugai, Y., Fukazawa, Y., Bertaso, F., Raynaud, F., Perroy,
    J., … Ferraguti, F. (2015). Distinct subsynaptic localization of type 1 metabotropic
    glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
    cortex. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/ejn.12779">https://doi.org/10.1111/ejn.12779</a>
  chicago: Mansouri, Mahnaz, Yu Kasugai, Yugo Fukazawa, Federica Bertaso, Fabrice
    Raynaud, Julie Perroy, Laurent Fagni, et al. “Distinct Subsynaptic Localization
    of Type 1 Metabotropic Glutamate Receptors at Glutamatergic and GABAergic Synapses
    in the Rodent Cerebellar Cortex.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell,
    2015. <a href="https://doi.org/10.1111/ejn.12779">https://doi.org/10.1111/ejn.12779</a>.
  ieee: M. Mansouri <i>et al.</i>, “Distinct subsynaptic localization of type 1 metabotropic
    glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar
    cortex,” <i>European Journal of Neuroscience</i>, vol. 41, no. 2. Wiley-Blackwell,
    pp. 157–167, 2015.
  ista: Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, Fagni L,
    Kaufmann W, Watanabe M, Shigemoto R, Ferraguti F. 2015. Distinct subsynaptic localization
    of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses
    in the rodent cerebellar cortex. European Journal of Neuroscience. 41(2), 157–167.
  mla: Mansouri, Mahnaz, et al. “Distinct Subsynaptic Localization of Type 1 Metabotropic
    Glutamate Receptors at Glutamatergic and GABAergic Synapses in the Rodent Cerebellar
    Cortex.” <i>European Journal of Neuroscience</i>, vol. 41, no. 2, Wiley-Blackwell,
    2015, pp. 157–67, doi:<a href="https://doi.org/10.1111/ejn.12779">10.1111/ejn.12779</a>.
  short: M. Mansouri, Y. Kasugai, Y. Fukazawa, F. Bertaso, F. Raynaud, J. Perroy,
    L. Fagni, W. Kaufmann, M. Watanabe, R. Shigemoto, F. Ferraguti, European Journal
    of Neuroscience 41 (2015) 157–167.
date_created: 2018-12-11T11:52:28Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2023-02-23T10:02:24Z
day: '01'
doi: 10.1111/ejn.12779
extern: 1
intvolume: '        41'
issue: '2'
month: '01'
page: 157 - 167
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5662'
quality_controlled: 0
status: public
title: Distinct subsynaptic localization of type 1 metabotropic glutamate receptors
  at glutamatergic and GABAergic synapses in the rodent cerebellar cortex
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 41
year: '2015'
...
---
_id: '1517'
abstract:
- lang: eng
  text: "We study the large deviation rate functional for the empirical distribution
    of independent Brownian particles with drift. In one dimension, it has been shown
    by Adams, Dirr, Peletier and Zimmer that this functional is asymptotically equivalent
    (in the sense of Γ-convergence) to the Jordan-Kinderlehrer-Otto functional arising
    in the Wasserstein gradient flow structure of the Fokker-Planck equation. In higher
    dimensions, part of this statement (the lower bound) has been recently proved
    by Duong, Laschos and Renger, but the upper bound remained open, since the proof
    of Duong et al relies on regularity properties of optimal transport maps that
    are restricted to one dimension. In this note we present a new proof of the upper
    bound, thereby generalising the result of Adams et al to arbitrary dimensions.\r\n"
article_number: '89'
author:
- first_name: Matthias
  full_name: Erbar, Matthias
  last_name: Erbar
- first_name: Jan
  full_name: Maas, Jan
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
- first_name: Michiel
  full_name: Renger, Michiel
  last_name: Renger
citation:
  ama: Erbar M, Maas J, Renger M. From large deviations to Wasserstein gradient flows
    in multiple dimensions. <i>Electronic Communications in Probability</i>. 2015;20.
    doi:<a href="https://doi.org/10.1214/ECP.v20-4315">10.1214/ECP.v20-4315</a>
  apa: Erbar, M., Maas, J., &#38; Renger, M. (2015). From large deviations to Wasserstein
    gradient flows in multiple dimensions. <i>Electronic Communications in Probability</i>.
    Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/ECP.v20-4315">https://doi.org/10.1214/ECP.v20-4315</a>
  chicago: Erbar, Matthias, Jan Maas, and Michiel Renger. “From Large Deviations to
    Wasserstein Gradient Flows in Multiple Dimensions.” <i>Electronic Communications
    in Probability</i>. Institute of Mathematical Statistics, 2015. <a href="https://doi.org/10.1214/ECP.v20-4315">https://doi.org/10.1214/ECP.v20-4315</a>.
  ieee: M. Erbar, J. Maas, and M. Renger, “From large deviations to Wasserstein gradient
    flows in multiple dimensions,” <i>Electronic Communications in Probability</i>,
    vol. 20. Institute of Mathematical Statistics, 2015.
  ista: Erbar M, Maas J, Renger M. 2015. From large deviations to Wasserstein gradient
    flows in multiple dimensions. Electronic Communications in Probability. 20, 89.
  mla: Erbar, Matthias, et al. “From Large Deviations to Wasserstein Gradient Flows
    in Multiple Dimensions.” <i>Electronic Communications in Probability</i>, vol.
    20, 89, Institute of Mathematical Statistics, 2015, doi:<a href="https://doi.org/10.1214/ECP.v20-4315">10.1214/ECP.v20-4315</a>.
  short: M. Erbar, J. Maas, M. Renger, Electronic Communications in Probability 20
    (2015).
date_created: 2018-12-11T11:52:29Z
date_published: 2015-11-29T00:00:00Z
date_updated: 2021-01-12T06:51:19Z
day: '29'
ddc:
- '519'
department:
- _id: JaMa
doi: 10.1214/ECP.v20-4315
file:
- access_level: open_access
  checksum: 135741c17d3e1547ca696b6fbdcd559c
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:39Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4828'
  file_name: IST-2016-494-v1+1_4315-23820-1-PB.pdf
  file_size: 230525
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        20'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Electronic Communications in Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '5660'
pubrep_id: '494'
quality_controlled: '1'
scopus_import: 1
status: public
title: From large deviations to Wasserstein gradient flows in multiple dimensions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2015'
...
---
_id: '1519'
abstract:
- lang: eng
  text: Evolutionary biologists have an array of powerful theoretical techniques that
    can accurately predict changes in the genetic composition of populations. Changes
    in gene frequencies and genetic associations between loci can be tracked as they
    respond to a wide variety of evolutionary forces. However, it is often less clear
    how to decompose these various forces into components that accurately reflect
    the underlying biology. Here, we present several issues that arise in the definition
    and interpretation of selection and selection coefficients, focusing on insights
    gained through the examination of selection coefficients in multilocus notation.
    Using this notation, we discuss how its flexibility-which allows different biological
    units to be identified as targets of selection-is reflected in the interpretation
    of the coefficients that the notation generates. In many situations, it can be
    difficult to agree on whether loci can be considered to be under &quot;direct&quot;
    versus &quot;indirect&quot; selection, or to quantify this selection. We present
    arguments for what the terms direct and indirect selection might best encompass,
    considering a range of issues, from viability and sexual selection to kin selection.
    We show how multilocus notation can discriminate between direct and indirect selection,
    and describe when it can do so.
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Maria
  full_name: Servedio, Maria
  last_name: Servedio
citation:
  ama: Barton NH, Servedio M. The interpretation of selection coefficients. <i>Evolution</i>.
    2015;69(5):1101-1112. doi:<a href="https://doi.org/10.1111/evo.12641">10.1111/evo.12641</a>
  apa: Barton, N. H., &#38; Servedio, M. (2015). The interpretation of selection coefficients.
    <i>Evolution</i>. Wiley. <a href="https://doi.org/10.1111/evo.12641">https://doi.org/10.1111/evo.12641</a>
  chicago: Barton, Nicholas H, and Maria Servedio. “The Interpretation of Selection
    Coefficients.” <i>Evolution</i>. Wiley, 2015. <a href="https://doi.org/10.1111/evo.12641">https://doi.org/10.1111/evo.12641</a>.
  ieee: N. H. Barton and M. Servedio, “The interpretation of selection coefficients,”
    <i>Evolution</i>, vol. 69, no. 5. Wiley, pp. 1101–1112, 2015.
  ista: Barton NH, Servedio M. 2015. The interpretation of selection coefficients.
    Evolution. 69(5), 1101–1112.
  mla: Barton, Nicholas H., and Maria Servedio. “The Interpretation of Selection Coefficients.”
    <i>Evolution</i>, vol. 69, no. 5, Wiley, 2015, pp. 1101–12, doi:<a href="https://doi.org/10.1111/evo.12641">10.1111/evo.12641</a>.
  short: N.H. Barton, M. Servedio, Evolution 69 (2015) 1101–1112.
date_created: 2018-12-11T11:52:29Z
date_published: 2015-03-19T00:00:00Z
date_updated: 2021-01-12T06:51:20Z
day: '19'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/evo.12641
ec_funded: 1
file:
- access_level: open_access
  checksum: fd8d23f476bc194419929b72ca265c02
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:34Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4822'
  file_name: IST-2016-560-v1+1_Interpreting_ML_coefficients_11.2.15_App.pdf
  file_size: 188872
  relation: main_file
- access_level: open_access
  checksum: b774911e70044641d556e258efcb52ef
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:35Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4823'
  file_name: IST-2016-560-v1+2_Interpreting_ML_coefficients_11.2.15_mainText.pdf
  file_size: 577415
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        69'
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1101 - 1112
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
publication: Evolution
publication_status: published
publisher: Wiley
publist_id: '5656'
pubrep_id: '560'
quality_controlled: '1'
scopus_import: 1
status: public
title: The interpretation of selection coefficients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 69
year: '2015'
...
---
_id: '1520'
abstract:
- lang: eng
  text: Creating mechanical automata that can walk in stable and pleasing manners
    is a challenging task that requires both skill and expertise. We propose to use
    computational design to offset the technical difficulties of this process. A simple
    drag-and-drop interface allows casual users to create personalized walking toys
    from a library of pre-defined template mechanisms. Provided with this input, our
    method leverages physical simulation and evolutionary optimization to refine the
    mechanical designs such that the resulting toys are able to walk. The optimization
    process is guided by an intuitive set of objectives that measure the quality of
    the walking motions. We demonstrate our approach on a set of simulated mechanical
    toys with different numbers of legs and various distinct gaits. Two fabricated
    prototypes showcase the feasibility of our designs.
author:
- first_name: Gaurav
  full_name: Bharaj, Gaurav
  last_name: Bharaj
- first_name: Stelian
  full_name: Coros, Stelian
  last_name: Coros
- first_name: Bernhard
  full_name: Thomaszewski, Bernhard
  last_name: Thomaszewski
- first_name: James
  full_name: Tompkin, James
  last_name: Tompkin
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Hanspeter
  full_name: Pfister, Hanspeter
  last_name: Pfister
citation:
  ama: 'Bharaj G, Coros S, Thomaszewski B, Tompkin J, Bickel B, Pfister H. Computational
    design of walking automata. In: ACM; 2015:93-100. doi:<a href="https://doi.org/10.1145/2786784.2786803">10.1145/2786784.2786803</a>'
  apa: 'Bharaj, G., Coros, S., Thomaszewski, B., Tompkin, J., Bickel, B., &#38; Pfister,
    H. (2015). Computational design of walking automata (pp. 93–100). Presented at
    the SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation, Los Angeles,
    CA, United States: ACM. <a href="https://doi.org/10.1145/2786784.2786803">https://doi.org/10.1145/2786784.2786803</a>'
  chicago: Bharaj, Gaurav, Stelian Coros, Bernhard Thomaszewski, James Tompkin, Bernd
    Bickel, and Hanspeter Pfister. “Computational Design of Walking Automata,” 93–100.
    ACM, 2015. <a href="https://doi.org/10.1145/2786784.2786803">https://doi.org/10.1145/2786784.2786803</a>.
  ieee: 'G. Bharaj, S. Coros, B. Thomaszewski, J. Tompkin, B. Bickel, and H. Pfister,
    “Computational design of walking automata,” presented at the SCA: ACM SIGGRAPH/Eurographics
    Symposium on Computer animation, Los Angeles, CA, United States, 2015, pp. 93–100.'
  ista: 'Bharaj G, Coros S, Thomaszewski B, Tompkin J, Bickel B, Pfister H. 2015.
    Computational design of walking automata. SCA: ACM SIGGRAPH/Eurographics Symposium
    on Computer animation, 93–100.'
  mla: Bharaj, Gaurav, et al. <i>Computational Design of Walking Automata</i>. ACM,
    2015, pp. 93–100, doi:<a href="https://doi.org/10.1145/2786784.2786803">10.1145/2786784.2786803</a>.
  short: G. Bharaj, S. Coros, B. Thomaszewski, J. Tompkin, B. Bickel, H. Pfister,
    in:, ACM, 2015, pp. 93–100.
conference:
  end_date: 2015-08-09
  location: Los Angeles, CA, United States
  name: 'SCA: ACM SIGGRAPH/Eurographics Symposium on Computer animation'
  start_date: 2015-08-07
date_created: 2018-12-11T11:52:30Z
date_published: 2015-08-01T00:00:00Z
date_updated: 2021-01-12T06:51:21Z
day: '01'
department:
- _id: BeBi
doi: 10.1145/2786784.2786803
language:
- iso: eng
month: '08'
oa_version: None
page: 93 - 100
publication_identifier:
  isbn:
  - 978-1-4503-3496-9
publication_status: published
publisher: ACM
publist_id: '5655'
quality_controlled: '1'
scopus_import: 1
status: public
title: Computational design of walking automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2015'
...
---
_id: '1525'
abstract:
- lang: eng
  text: 'Based on 16 recommendations, efforts should be made to achieve the following
    goal: By 2025, all scholarly publication activity in Austria should be Open Access.
    In other words, the final versions of all scholarly publications resulting from
    the support of public resources must be freely accessible on the Internet without
    delay (Gold Open Access). The resources required to meet this obligation shall
    be provided to the authors, or the cost of the publication venues shall be borne
    directly by the research organisations.'
article_processing_charge: No
article_type: original
author:
- first_name: Bruno
  full_name: Bauer, Bruno
  last_name: Bauer
- first_name: Guido
  full_name: Blechl, Guido
  last_name: Blechl
- first_name: Christoph
  full_name: Bock, Christoph
  last_name: Bock
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
- first_name: Andreas
  full_name: Ferus, Andreas
  last_name: Ferus
- first_name: Anton
  full_name: Graschopf, Anton
  last_name: Graschopf
- first_name: Thomas
  full_name: König, Thomas
  last_name: König
- first_name: Katja
  full_name: Mayer, Katja
  last_name: Mayer
- first_name: Falk
  full_name: Reckling, Falk
  last_name: Reckling
- first_name: Katharina
  full_name: Rieck, Katharina
  last_name: Rieck
- first_name: Peter
  full_name: Seitz, Peter
  last_name: Seitz
- first_name: Herwig
  full_name: Stöger, Herwig
  last_name: Stöger
- first_name: Elvira
  full_name: Welzig, Elvira
  last_name: Welzig
citation:
  ama: Bauer B, Blechl G, Bock C, et al. Arbeitsgruppe „Nationale Strategie“ des Open
    Access Network Austria OANA. <i>VÖB Mitteilungen</i>. 2015;68(3):580-607. doi:<a
    href="https://doi.org/10.5281/zenodo.33178">10.5281/zenodo.33178</a>
  apa: Bauer, B., Blechl, G., Bock, C., Danowski, P., Ferus, A., Graschopf, A., …
    Welzig, E. (2015). Arbeitsgruppe „Nationale Strategie“ des Open Access Network
    Austria OANA. <i>VÖB Mitteilungen</i>. Verein Österreichischer Bibliothekare.
    <a href="https://doi.org/10.5281/zenodo.33178">https://doi.org/10.5281/zenodo.33178</a>
  chicago: Bauer, Bruno, Guido Blechl, Christoph Bock, Patrick Danowski, Andreas Ferus,
    Anton Graschopf, Thomas König, et al. “Arbeitsgruppe „Nationale Strategie“ Des
    Open Access Network Austria OANA.” <i>VÖB Mitteilungen</i>. Verein Österreichischer
    Bibliothekare, 2015. <a href="https://doi.org/10.5281/zenodo.33178">https://doi.org/10.5281/zenodo.33178</a>.
  ieee: B. Bauer <i>et al.</i>, “Arbeitsgruppe „Nationale Strategie“ des Open Access
    Network Austria OANA,” <i>VÖB Mitteilungen</i>, vol. 68, no. 3. Verein Österreichischer
    Bibliothekare, pp. 580–607, 2015.
  ista: Bauer B, Blechl G, Bock C, Danowski P, Ferus A, Graschopf A, König T, Mayer
    K, Reckling F, Rieck K, Seitz P, Stöger H, Welzig E. 2015. Arbeitsgruppe „Nationale
    Strategie“ des Open Access Network Austria OANA. VÖB Mitteilungen. 68(3), 580–607.
  mla: Bauer, Bruno, et al. “Arbeitsgruppe „Nationale Strategie“ Des Open Access Network
    Austria OANA.” <i>VÖB Mitteilungen</i>, vol. 68, no. 3, Verein Österreichischer
    Bibliothekare, 2015, pp. 580–607, doi:<a href="https://doi.org/10.5281/zenodo.33178">10.5281/zenodo.33178</a>.
  short: B. Bauer, G. Blechl, C. Bock, P. Danowski, A. Ferus, A. Graschopf, T. König,
    K. Mayer, F. Reckling, K. Rieck, P. Seitz, H. Stöger, E. Welzig, VÖB Mitteilungen
    68 (2015) 580–607.
date_created: 2018-12-11T11:52:31Z
date_published: 2015-11-12T00:00:00Z
date_updated: 2021-01-12T06:51:22Z
day: '12'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.5281/zenodo.33178
file:
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  date_created: 2018-12-12T10:17:59Z
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  file_name: IST-2016-720-v1+1_OANA_OA-Empfehlungen_12-11-2015.pdf
  file_size: 931707
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file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '        68'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 580 - 607
publication: VÖB Mitteilungen
publication_status: published
publisher: Verein Österreichischer Bibliothekare
publist_id: '5648'
pubrep_id: '720'
quality_controlled: '1'
scopus_import: 1
status: public
title: Arbeitsgruppe „Nationale Strategie“ des Open Access Network Austria OANA
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2015'
...
---
_id: '1530'
abstract:
- lang: eng
  text: In growing cells, protein synthesis and cell growth are typically not synchronous,
    and, thus, protein concentrations vary over the cell division cycle. We have developed
    a theoretical description of genetic regulatory systems in bacteria that explicitly
    considers the cell division cycle to investigate its impact on gene expression.
    We calculate the cell-to-cell variations arising from cells being at different
    stages in the division cycle for unregulated genes and for basic regulatory mechanisms.
    These variations contribute to the extrinsic noise observed in single-cell experiments,
    and are most significant for proteins with short lifetimes. Negative autoregulation
    buffers against variation of protein concentration over the division cycle, but
    the effect is found to be relatively weak. Stronger buffering is achieved by an
    increased protein lifetime. Positive autoregulation can strongly amplify such
    variation if the parameters are set to values that lead to resonance-like behaviour.
    For cooperative positive autoregulation, the concentration variation over the
    division cycle diminishes the parameter region of bistability and modulates the
    switching times between the two stable states. The same effects are seen for a
    two-gene mutual-repression toggle switch. By contrast, an oscillatory circuit,
    the repressilator, is only weakly affected by the division cycle.
article_number: '066003'
author:
- first_name: Veronika
  full_name: Bierbaum, Veronika
  id: 3FD04378-F248-11E8-B48F-1D18A9856A87
  last_name: Bierbaum
- first_name: Stefan
  full_name: Klumpp, Stefan
  last_name: Klumpp
citation:
  ama: Bierbaum V, Klumpp S. Impact of the cell division cycle on gene circuits. <i>Physical
    Biology</i>. 2015;12(6). doi:<a href="https://doi.org/10.1088/1478-3975/12/6/066003">10.1088/1478-3975/12/6/066003</a>
  apa: Bierbaum, V., &#38; Klumpp, S. (2015). Impact of the cell division cycle on
    gene circuits. <i>Physical Biology</i>. IOP Publishing Ltd. <a href="https://doi.org/10.1088/1478-3975/12/6/066003">https://doi.org/10.1088/1478-3975/12/6/066003</a>
  chicago: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle
    on Gene Circuits.” <i>Physical Biology</i>. IOP Publishing Ltd., 2015. <a href="https://doi.org/10.1088/1478-3975/12/6/066003">https://doi.org/10.1088/1478-3975/12/6/066003</a>.
  ieee: V. Bierbaum and S. Klumpp, “Impact of the cell division cycle on gene circuits,”
    <i>Physical Biology</i>, vol. 12, no. 6. IOP Publishing Ltd., 2015.
  ista: Bierbaum V, Klumpp S. 2015. Impact of the cell division cycle on gene circuits.
    Physical Biology. 12(6), 066003.
  mla: Bierbaum, Veronika, and Stefan Klumpp. “Impact of the Cell Division Cycle on
    Gene Circuits.” <i>Physical Biology</i>, vol. 12, no. 6, 066003, IOP Publishing
    Ltd., 2015, doi:<a href="https://doi.org/10.1088/1478-3975/12/6/066003">10.1088/1478-3975/12/6/066003</a>.
  short: V. Bierbaum, S. Klumpp, Physical Biology 12 (2015).
date_created: 2018-12-11T11:52:33Z
date_published: 2015-09-25T00:00:00Z
date_updated: 2021-01-12T06:51:25Z
day: '25'
department:
- _id: MiSi
doi: 10.1088/1478-3975/12/6/066003
intvolume: '        12'
issue: '6'
language:
- iso: eng
month: '09'
oa_version: None
publication: Physical Biology
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '5641'
quality_controlled: '1'
scopus_import: 1
status: public
title: Impact of the cell division cycle on gene circuits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2015'
...
