---
_id: '6733'
abstract:
- lang: eng
  text: 'The question whether RM codes are capacity-achieving is a long-standing open
    problem in coding theory that was recently answered in the affirmative for transmission
    over erasure channels [1], [2]. Remarkably, the proof does not rely on specific
    properties of RM codes, apart from their symmetry. Indeed, the main technical
    result consists in showing that any sequence of linear codes, with doubly-transitive
    permutation groups, achieves capacity on the memoryless erasure channel under
    bit-MAP decoding. Thus, a natural question is what happens under block-MAP decoding.
    In [1], [2], by exploiting further symmetries of the code, the bit-MAP threshold
    was shown to be sharp enough so that the block erasure probability also converges
    to 0. However, this technique relies heavily on the fact that the transmission
    is over an erasure channel. We present an alternative approach to strengthen results
    regarding the bit-MAP threshold to block-MAP thresholds. This approach is based
    on a careful analysis of the weight distribution of RM codes. In particular, the
    flavor of the main result is the following: assume that the bit-MAP error probability
    decays as N -δ , for some δ > 0. Then, the block-MAP error probability also converges
    to 0. This technique applies to transmission over any binary memoryless symmetric
    channel. Thus, it can be thought of as a first step in extending the proof that
    RM codes are capacity-achieving to the general case.'
arxiv: 1
author:
- first_name: Shrinivas
  full_name: Kudekar, Shrinivas
  last_name: Kudekar
- first_name: Santhosh
  full_name: Kumar, Santhosh
  last_name: Kumar
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Henry D.
  full_name: Pfister, Henry D.
  last_name: Pfister
- first_name: Rudiger
  full_name: Urbankez, Rudiger
  last_name: Urbankez
citation:
  ama: 'Kudekar S, Kumar S, Mondelli M, Pfister HD, Urbankez R. Comparing the bit-MAP
    and block-MAP decoding thresholds of Reed-Muller codes on BMS channels. In: <i>2016
    IEEE International Symposium on Information Theory </i>. IEEE; 2016:1755-1759.
    doi:<a href="https://doi.org/10.1109/isit.2016.7541600">10.1109/isit.2016.7541600</a>'
  apa: 'Kudekar, S., Kumar, S., Mondelli, M., Pfister, H. D., &#38; Urbankez, R. (2016).
    Comparing the bit-MAP and block-MAP decoding thresholds of Reed-Muller codes on
    BMS channels. In <i>2016 IEEE International Symposium on Information Theory </i>
    (pp. 1755–1759). Barcelona, Spain: IEEE. <a href="https://doi.org/10.1109/isit.2016.7541600">https://doi.org/10.1109/isit.2016.7541600</a>'
  chicago: Kudekar, Shrinivas, Santhosh Kumar, Marco Mondelli, Henry D. Pfister, and
    Rudiger Urbankez. “Comparing the Bit-MAP and Block-MAP Decoding Thresholds of
    Reed-Muller Codes on BMS Channels.” In <i>2016 IEEE International Symposium on
    Information Theory </i>, 1755–59. IEEE, 2016. <a href="https://doi.org/10.1109/isit.2016.7541600">https://doi.org/10.1109/isit.2016.7541600</a>.
  ieee: S. Kudekar, S. Kumar, M. Mondelli, H. D. Pfister, and R. Urbankez, “Comparing
    the bit-MAP and block-MAP decoding thresholds of Reed-Muller codes on BMS channels,”
    in <i>2016 IEEE International Symposium on Information Theory </i>, Barcelona,
    Spain, 2016, pp. 1755–1759.
  ista: 'Kudekar S, Kumar S, Mondelli M, Pfister HD, Urbankez R. 2016. Comparing the
    bit-MAP and block-MAP decoding thresholds of Reed-Muller codes on BMS channels.
    2016 IEEE International Symposium on Information Theory . ISIT: International
    Symposium on Information Theory, 1755–1759.'
  mla: Kudekar, Shrinivas, et al. “Comparing the Bit-MAP and Block-MAP Decoding Thresholds
    of Reed-Muller Codes on BMS Channels.” <i>2016 IEEE International Symposium on
    Information Theory </i>, IEEE, 2016, pp. 1755–59, doi:<a href="https://doi.org/10.1109/isit.2016.7541600">10.1109/isit.2016.7541600</a>.
  short: S. Kudekar, S. Kumar, M. Mondelli, H.D. Pfister, R. Urbankez, in:, 2016 IEEE
    International Symposium on Information Theory , IEEE, 2016, pp. 1755–1759.
conference:
  end_date: 2016-07-15
  location: Barcelona, Spain
  name: 'ISIT: International Symposium on Information Theory'
  start_date: 2016-07-10
date_created: 2019-07-31T06:36:16Z
date_published: 2016-08-11T00:00:00Z
date_updated: 2021-01-12T08:08:44Z
day: '11'
doi: 10.1109/isit.2016.7541600
extern: '1'
external_id:
  arxiv:
  - '1601.06048'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1601.06048
month: '08'
oa: 1
oa_version: Preprint
page: 1755-1759
publication: '2016 IEEE International Symposium on Information Theory '
publication_status: published
publisher: IEEE
quality_controlled: '1'
status: public
title: Comparing the bit-MAP and block-MAP decoding thresholds of Reed-Muller codes
  on BMS channels
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '6770'
abstract:
- lang: eng
  text: "We describe a new method to compare the bit-MAP and block-MAP decoding thresholds
    of Reed-Muller (RM) codes for transmission over a binary memoryless symmetric
    channel. The question whether RM codes are capacity-achieving is a long-standing
    open problem in coding theory and it has recently been answered in the affirmative
    for transmission over\r\nerasure channels. Remarkably, the proof does not rely
    on specific properties of RM codes, apart from their symmetry. Indeed, the main
    technical result consists in showing that any sequence of linear codes, with doubly-transitive
    permutation groups, achieves capacity on the memoryless erasure channel under
    bit-MAP decoding. A natural question is what happens under block-MAP decoding.
    If the minimum distance of the code family is close to linear (e.g., of order
    N/ log(N)), then one can combine an upper bound on the bit-MAP error probability
    with a lower bound on the minimum distance to show that the code family is also
    capacity-achieving under block-MAP decoding. This strategy is successful for BCH
    codes. Unfortunately, the minimum distance of RM codes scales only as √N, which
    does not suffice to obtain the desired result. Then, one can exploit further symmetries
    of RM codes to show that the bit-MAP threshold is sharp enough so that the block
    erasure probability also tends to 0. However, this technique relies heavily on
    the fact that the transmission is over an erasure channel.\r\nWe present an alternative
    approach to strengthen results regarding the bit-MAP threshold to block-MAP thresholds.
    This approach is based on a careful analysis of the weight distribution of RM
    codes. In particular, the flavor of the main result is the following: assume that
    the bit-MAP error probability decays as N−δ, for some δ > 0. Then, the block-MAP\r\nerror
    probability also converges to 0. This technique applies to the transmission over
    any binary memoryless symmetric channel. Thus, it can be thought of as a first
    step in extending the proof that RM codes are capacity-achieving to the general
    case."
author:
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Shrinivas
  full_name: Kudekar, Shrinivas
  last_name: Kudekar
- first_name: Santosh
  full_name: Kumar, Santosh
  last_name: Kumar
- first_name: Henry D.
  full_name: Pfister, Henry D.
  last_name: Pfister
- first_name: Eren
  full_name: Şaşoğlu, Eren
  last_name: Şaşoğlu
- first_name: Rüdiger
  full_name: Urbanke, Rüdiger
  last_name: Urbanke
citation:
  ama: 'Mondelli M, Kudekar S, Kumar S, Pfister HD, Şaşoğlu E, Urbanke R. Reed-Muller
    codes: Thresholds and weight distribution. In: <i>24th International Zurich Seminar
    on Communications</i>. ETH Zürich; 2016:50. doi:<a href="https://doi.org/10.3929/ETHZ-A-010646484">10.3929/ETHZ-A-010646484</a>'
  apa: 'Mondelli, M., Kudekar, S., Kumar, S., Pfister, H. D., Şaşoğlu, E., &#38; Urbanke,
    R. (2016). Reed-Muller codes: Thresholds and weight distribution. In <i>24th International
    Zurich Seminar on Communications</i> (p. 50). Zurich, Switzerland: ETH Zürich.
    <a href="https://doi.org/10.3929/ETHZ-A-010646484">https://doi.org/10.3929/ETHZ-A-010646484</a>'
  chicago: 'Mondelli, Marco, Shrinivas Kudekar, Santosh Kumar, Henry D. Pfister, Eren
    Şaşoğlu, and Rüdiger Urbanke. “Reed-Muller Codes: Thresholds and Weight Distribution.”
    In <i>24th International Zurich Seminar on Communications</i>, 50. ETH Zürich,
    2016. <a href="https://doi.org/10.3929/ETHZ-A-010646484">https://doi.org/10.3929/ETHZ-A-010646484</a>.'
  ieee: 'M. Mondelli, S. Kudekar, S. Kumar, H. D. Pfister, E. Şaşoğlu, and R. Urbanke,
    “Reed-Muller codes: Thresholds and weight distribution,” in <i>24th International
    Zurich Seminar on Communications</i>, Zurich, Switzerland, 2016, p. 50.'
  ista: 'Mondelli M, Kudekar S, Kumar S, Pfister HD, Şaşoğlu E, Urbanke R. 2016. Reed-Muller
    codes: Thresholds and weight distribution. 24th International Zurich Seminar on
    Communications. IZS: International Zurich Seminar on Communications, 50.'
  mla: 'Mondelli, Marco, et al. “Reed-Muller Codes: Thresholds and Weight Distribution.”
    <i>24th International Zurich Seminar on Communications</i>, ETH Zürich, 2016,
    p. 50, doi:<a href="https://doi.org/10.3929/ETHZ-A-010646484">10.3929/ETHZ-A-010646484</a>.'
  short: M. Mondelli, S. Kudekar, S. Kumar, H.D. Pfister, E. Şaşoğlu, R. Urbanke,
    in:, 24th International Zurich Seminar on Communications, ETH Zürich, 2016, p.
    50.
conference:
  end_date: 2016-03-04
  location: Zurich, Switzerland
  name: 'IZS: International Zurich Seminar on Communications'
  start_date: 2016-03-02
date_created: 2019-08-05T12:43:48Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2021-01-12T08:08:57Z
day: '01'
doi: 10.3929/ETHZ-A-010646484
extern: '1'
language:
- iso: eng
month: '03'
oa_version: None
page: '50'
publication: 24th International Zurich Seminar on Communications
publication_status: published
publisher: ETH Zürich
quality_controlled: '1'
status: public
title: 'Reed-Muller codes: Thresholds and weight distribution'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...
---
_id: '100'
abstract:
- lang: eng
  text: We introduce a scheme for preparation, manipulation, and read out of Majorana
    zero modes in semiconducting wires with mesoscopic superconducting islands. Our
    approach synthesizes recent advances in materials growth with tools commonly used
    in quantum-dot experiments, including gate control of tunnel barriers and Coulomb
    effects, charge sensing, and charge pumping. We outline a sequence of milestones
    interpolating between zero-mode detection and quantum computing that includes
    (1) detection of fusion rules for non-Abelian anyons using either proximal charge
    sensors or pumped current, (2) validation of a prototype topological qubit, and
    (3) demonstration of non-Abelian statistics by braiding in a branched geometry.
    The first two milestones require only a single wire with two islands, and additionally
    enable sensitive measurements of the system\'s excitation gap, quasiparticle poisoning
    rates, residual Majorana zero-mode splittings, and topological-qubit coherence
    times. These pre-braiding experiments can be adapted to other manipulation and
    read out schemes as well.
acknowledgement: We acknowledge support from Microsoft Research, the National Science
  Foundation through Grant No. DMR-1341822 (J. A.); the Alfred P. Sloan Foundation
  (J. A.); the Caltech Institute for Quantum Information and Matter, an NSF Physics
  Frontiers Center with support of the Gordon and Betty Moore Foundation through Grant
  No. GBMF1250; the Walter Burke Institute for Theoretical Physics at Caltech; the
  NSERC PGSD program (D. A.); the Crafoord Foundation (M. L. and M. H.) and the Swedish
  Research Council (M. L.); The Danish National Research Foundation, and the Villum
  Foundation (C. M.); The Danish Council for Independent Research/Natural Sciences,
  and Danmarks Nationalbank (J. F.). Part of this work was performed at the Aspen
  Center for Physics, which is supported by National Science Foundation Grant No.
  PHY-1066293 (R. V. M.).
article_number: '031016'
author:
- first_name: David
  full_name: Aasen, David
  last_name: Aasen
- first_name: Michael
  full_name: Hell, Michael
  last_name: Hell
- first_name: Ryan
  full_name: Mishmash, Ryan
  last_name: Mishmash
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: Jeroen
  full_name: Danon, Jeroen
  last_name: Danon
- first_name: Martin
  full_name: Leijnse, Martin
  last_name: Leijnse
- first_name: Thomas
  full_name: Jespersen, Thomas
  last_name: Jespersen
- first_name: Joshua
  full_name: Folk, Joshua
  last_name: Folk
- first_name: Charles
  full_name: Marcs, Charles
  last_name: Marcs
- first_name: Karsten
  full_name: Flensberg, Karsten
  last_name: Flensberg
- first_name: Jason
  full_name: Alicea, Jason
  last_name: Alicea
citation:
  ama: Aasen D, Hell M, Mishmash R, et al. Milestones toward Majorana-based quantum
    computing. <i>Physical Review X</i>. 2016;6(3). doi:<a href="https://doi.org/10.1103/PhysRevX.6.031016">10.1103/PhysRevX.6.031016</a>
  apa: Aasen, D., Hell, M., Mishmash, R., Higginbotham, A. P., Danon, J., Leijnse,
    M., … Alicea, J. (2016). Milestones toward Majorana-based quantum computing. <i>Physical
    Review X</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevX.6.031016">https://doi.org/10.1103/PhysRevX.6.031016</a>
  chicago: Aasen, David, Michael Hell, Ryan Mishmash, Andrew P Higginbotham, Jeroen
    Danon, Martin Leijnse, Thomas Jespersen, et al. “Milestones toward Majorana-Based
    Quantum Computing.” <i>Physical Review X</i>. American Physical Society, 2016.
    <a href="https://doi.org/10.1103/PhysRevX.6.031016">https://doi.org/10.1103/PhysRevX.6.031016</a>.
  ieee: D. Aasen <i>et al.</i>, “Milestones toward Majorana-based quantum computing,”
    <i>Physical Review X</i>, vol. 6, no. 3. American Physical Society, 2016.
  ista: Aasen D, Hell M, Mishmash R, Higginbotham AP, Danon J, Leijnse M, Jespersen
    T, Folk J, Marcs C, Flensberg K, Alicea J. 2016. Milestones toward Majorana-based
    quantum computing. Physical Review X. 6(3), 031016.
  mla: Aasen, David, et al. “Milestones toward Majorana-Based Quantum Computing.”
    <i>Physical Review X</i>, vol. 6, no. 3, 031016, American Physical Society, 2016,
    doi:<a href="https://doi.org/10.1103/PhysRevX.6.031016">10.1103/PhysRevX.6.031016</a>.
  short: D. Aasen, M. Hell, R. Mishmash, A.P. Higginbotham, J. Danon, M. Leijnse,
    T. Jespersen, J. Folk, C. Marcs, K. Flensberg, J. Alicea, Physical Review X 6
    (2016).
date_created: 2018-12-11T11:44:37Z
date_published: 2016-08-03T00:00:00Z
date_updated: 2021-01-12T06:47:33Z
day: '03'
ddc:
- '530'
doi: 10.1103/PhysRevX.6.031016
extern: '1'
file:
- access_level: open_access
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-05-15T14:12:31Z
  date_updated: 2019-05-15T14:12:31Z
  file_id: '6458'
  file_name: 2016_PhysRevX_Aasen.pdf
  file_size: 2142676
  relation: main_file
  success: 1
file_date_updated: 2019-05-15T14:12:31Z
has_accepted_license: '1'
intvolume: '         6'
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_status: published
publisher: American Physical Society
publist_id: '7954'
quality_controlled: '1'
status: public
title: Milestones toward Majorana-based quantum computing
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2016'
...
---
_id: '1008'
abstract:
- lang: eng
  text: Feedback loops in biological networks, among others, enable differentiation
    and cell cycle progression, and increase robustness in signal transduction. In
    natural networks, feedback loops are often complex and intertwined, making it
    challenging to identify which loops are mainly responsible for an observed behavior.
    However, minimal synthetic replicas could allow for such identification. Here,
    we engineered a synthetic permease-inducer-repressor system in Saccharomyces cerevisiae
    to analyze if a transport-mediated positive feedback loop could be a core mechanism
    for the switch-like behavior in the regulation of metabolic gene networks such
    as the S. cerevisiae GAL system or the Escherichia coli lac operon. We characterized
    the synthetic circuit using deterministic and stochastic mathematical models.
    Similar to its natural counterparts, our synthetic system shows bistable and hysteretic
    behavior, and the inducer concentration range for bistability as well as the switching
    rates between the two stable states depend on the repressor concentration. Our
    results indicate that a generic permease–inducer–repressor circuit with a single
    feedback loop is sufficient to explain the experimentally observed bistable behavior
    of the natural systems. We anticipate that the approach of reimplementing natural
    systems with orthogonal parts to identify crucial network components is applicable
    to other natural systems such as signaling pathways.
acknowledgement: We thank Julio Polaina (Instituto de Agroqu ı ́ mica y Tecnolog ı
  ́ a de Alimentos, C.S.I.C., Paterna, Spain) for the gift of plasmid pMR4, Gregor
  W. Schmidt for provision of and support with the micro fl uidic device, Markus Du
  ̈ rr for the cell tracking R script, and Lukas Widmer for the script for MEIGO using
  “ parfor ” in MATLAB. We acknowledge the members of the Stelling group for discussions,
  comments, and support.
author:
- first_name: Robert
  full_name: Gnügge, Robert
  last_name: Gnügge
- first_name: Lekshmi
  full_name: Dharmarajan, Lekshmi
  last_name: Dharmarajan
- first_name: Moritz
  full_name: Lang, Moritz
  id: 29E0800A-F248-11E8-B48F-1D18A9856A87
  last_name: Lang
- first_name: Jörg
  full_name: Stelling, Jörg
  last_name: Stelling
citation:
  ama: Gnügge R, Dharmarajan L, Lang M, Stelling J. An orthogonal permease–inducer–repressor
    feedback loop shows bistability. <i>ACS Synthetic Biology</i>. 2016;5(10):1098-1107.
    doi:<a href="https://doi.org/10.1021/acssynbio.6b00013">10.1021/acssynbio.6b00013</a>
  apa: Gnügge, R., Dharmarajan, L., Lang, M., &#38; Stelling, J. (2016). An orthogonal
    permease–inducer–repressor feedback loop shows bistability. <i>ACS Synthetic Biology</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acssynbio.6b00013">https://doi.org/10.1021/acssynbio.6b00013</a>
  chicago: Gnügge, Robert, Lekshmi Dharmarajan, Moritz Lang, and Jörg Stelling. “An
    Orthogonal Permease–Inducer–Repressor Feedback Loop Shows Bistability.” <i>ACS
    Synthetic Biology</i>. American Chemical Society, 2016. <a href="https://doi.org/10.1021/acssynbio.6b00013">https://doi.org/10.1021/acssynbio.6b00013</a>.
  ieee: R. Gnügge, L. Dharmarajan, M. Lang, and J. Stelling, “An orthogonal permease–inducer–repressor
    feedback loop shows bistability,” <i>ACS Synthetic Biology</i>, vol. 5, no. 10.
    American Chemical Society, pp. 1098–1107, 2016.
  ista: Gnügge R, Dharmarajan L, Lang M, Stelling J. 2016. An orthogonal permease–inducer–repressor
    feedback loop shows bistability. ACS Synthetic Biology. 5(10), 1098–1107.
  mla: Gnügge, Robert, et al. “An Orthogonal Permease–Inducer–Repressor Feedback Loop
    Shows Bistability.” <i>ACS Synthetic Biology</i>, vol. 5, no. 10, American Chemical
    Society, 2016, pp. 1098–107, doi:<a href="https://doi.org/10.1021/acssynbio.6b00013">10.1021/acssynbio.6b00013</a>.
  short: R. Gnügge, L. Dharmarajan, M. Lang, J. Stelling, ACS Synthetic Biology 5
    (2016) 1098–1107.
date_created: 2018-12-11T11:49:40Z
date_published: 2016-05-05T00:00:00Z
date_updated: 2021-01-12T06:47:37Z
day: '05'
department:
- _id: CaGu
doi: 10.1021/acssynbio.6b00013
intvolume: '         5'
issue: '10'
language:
- iso: eng
month: '05'
oa_version: None
page: 1098 - 1107
publication: ACS Synthetic Biology
publication_status: published
publisher: American Chemical Society
publist_id: '6390'
quality_controlled: '1'
status: public
title: An orthogonal permease–inducer–repressor feedback loop shows bistability
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2016'
...
---
_id: '101'
abstract:
- lang: eng
  text: Majorana zero modes are quasiparticle excitations in condensed matter systems
    that have been proposed as building blocks of fault-tolerant quantum computers.
    They are expected to exhibit non-Abelian particle statistics, in contrast to the
    usual statistics of fermions and bosons, enabling quantum operations to be performed
    by braiding isolated modes around one another. Quantum braiding operations are
    topologically protected insofar as these modes are pinned near zero energy, with
    the departure from zero expected to be exponentially small as the modes become
    spatially separated. Following theoretical proposals, several experiments have
    identified signatures of Majorana modes in nanowires with proximity-induced superconductivity
    and atomic chains, with small amounts of mode splitting potentially explained
    by hybridization of Majorana modes. Here, we use Coulomb-blockade spectroscopy
    in an InAs nanowire segment with epitaxial aluminium, which forms a proximity-induced
    superconducting Coulomb island (a â ∼ Majorana islandâ (tm)) that is isolated
    from normal-metal leads by tunnel barriers, to measure the splitting of near-zero-energy
    Majorana modes. We observe exponential suppression of energy splitting with increasing
    wire length. For short devices of a few hundred nanometres, sub-gap state energies
    oscillate as the magnetic field is varied, as is expected for hybridized Majorana
    modes. Splitting decreases by a factor of about ten for each half a micrometre
    of increased wire length. For devices longer than about one micrometre, transport
    in strong magnetic fields occurs through a zero-energy state that is energetically
    isolated from a continuum, yielding uniformly spaced Coulomb-blockade conductance
    peaks, consistent with teleportation via Majorana modes. Our results help to explain
    the trivial-to-topological transition in finite systems and to quantify the scaling
    of topological protection with end-mode separation.
acknowledgement: This research was supported by Microsoft Project Q, the Danish National
  Research Foundation, the Lundbeck Foundation, the Carlsberg Foundation and the European
  Commission. C.M.M. acknowledges support from the Villum Foundation.
arxiv: 1
author:
- first_name: S M
  full_name: Albrecht, S M
  last_name: Albrecht
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: Thomas
  full_name: Jespersen, Thomas
  last_name: Jespersen
- first_name: Morten
  full_name: Madsen, Morten
  last_name: Madsen
- first_name: Ferdinand
  full_name: Kuemmeth, Ferdinand
  last_name: Kuemmeth
- first_name: Jesper
  full_name: Nygård, Jesper
  last_name: Nygård
- first_name: Peter
  full_name: Krogstrup, Peter
  last_name: Krogstrup
- first_name: Charles
  full_name: Marcus, Charles
  last_name: Marcus
citation:
  ama: Albrecht SM, Higginbotham AP, Jespersen T, et al. Exponential protection of
    zero modes in Majorana islands. <i>Nature</i>. 2016;531(7593):206-209. doi:<a
    href="https://doi.org/10.1038/nature17162">10.1038/nature17162</a>
  apa: Albrecht, S. M., Higginbotham, A. P., Jespersen, T., Madsen, M., Kuemmeth,
    F., Nygård, J., … Marcus, C. (2016). Exponential protection of zero modes in Majorana
    islands. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nature17162">https://doi.org/10.1038/nature17162</a>
  chicago: Albrecht, S M, Andrew P Higginbotham, Thomas Jespersen, Morten Madsen,
    Ferdinand Kuemmeth, Jesper Nygård, Peter Krogstrup, and Charles Marcus. “Exponential
    Protection of Zero Modes in Majorana Islands.” <i>Nature</i>. Nature Publishing
    Group, 2016. <a href="https://doi.org/10.1038/nature17162">https://doi.org/10.1038/nature17162</a>.
  ieee: S. M. Albrecht <i>et al.</i>, “Exponential protection of zero modes in Majorana
    islands,” <i>Nature</i>, vol. 531, no. 7593. Nature Publishing Group, pp. 206–209,
    2016.
  ista: Albrecht SM, Higginbotham AP, Jespersen T, Madsen M, Kuemmeth F, Nygård J,
    Krogstrup P, Marcus C. 2016. Exponential protection of zero modes in Majorana
    islands. Nature. 531(7593), 206–209.
  mla: Albrecht, S. M., et al. “Exponential Protection of Zero Modes in Majorana Islands.”
    <i>Nature</i>, vol. 531, no. 7593, Nature Publishing Group, 2016, pp. 206–09,
    doi:<a href="https://doi.org/10.1038/nature17162">10.1038/nature17162</a>.
  short: S.M. Albrecht, A.P. Higginbotham, T. Jespersen, M. Madsen, F. Kuemmeth, J.
    Nygård, P. Krogstrup, C. Marcus, Nature 531 (2016) 206–209.
date_created: 2018-12-11T11:44:38Z
date_published: 2016-03-10T00:00:00Z
date_updated: 2021-01-12T06:47:37Z
day: '10'
doi: 10.1038/nature17162
extern: '1'
external_id:
  arxiv:
  - '1603.03217'
intvolume: '       531'
issue: '7593'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1603.03217
month: '03'
oa: 1
oa_version: Submitted Version
page: 206 - 209
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '7953'
quality_controlled: '1'
status: public
title: Exponential protection of zero modes in Majorana islands
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 531
year: '2016'
...
---
_id: '102'
abstract:
- lang: eng
  text: 'Recent experiments have produced mounting evidence of Majorana zero modes
    in nanowire-superconductor hybrids. Signatures of an expected topological phase
    transition accompanying the onset of these modes nevertheless remain elusive.
    We investigate a fundamental question concerning this issue: Do well-formed Majorana
    modes necessarily entail a sharp phase transition in these setups? Assuming reasonable
    parameters, we argue that finite-size effects can dramatically smooth this putative
    transition into a crossover, even in systems large enough to support well-localized
    Majorana modes. We propose overcoming such finite-size effects by examining the
    behavior of low-lying excited states through tunneling spectroscopy. In particular,
    the excited-state energies exhibit characteristic field and density dependence,
    and scaling with system size, that expose an approaching topological phase transition.
    We suggest several experiments for extracting the predicted behavior. As a useful
    byproduct, the protocols also allow one to measure the wire''s spin-orbit coupling
    directly in its superconducting environment.'
article_number: '245404'
arxiv: 1
author:
- first_name: Ryan
  full_name: Mishmash, Ryan
  last_name: Mishmash
- first_name: David
  full_name: Aasen, David
  last_name: Aasen
- first_name: Andrew P
  full_name: Higginbotham, Andrew P
  id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
  last_name: Higginbotham
  orcid: 0000-0003-2607-2363
- first_name: Jason
  full_name: Alicea, Jason
  last_name: Alicea
citation:
  ama: Mishmash R, Aasen D, Higginbotham AP, Alicea J. Approaching a topological phase
    transition in Majorana nanowires. <i>Physical Review B</i>. 2016;93(24). doi:<a
    href="https://doi.org/10.1103/PhysRevB.93.245404">10.1103/PhysRevB.93.245404</a>
  apa: Mishmash, R., Aasen, D., Higginbotham, A. P., &#38; Alicea, J. (2016). Approaching
    a topological phase transition in Majorana nanowires. <i>Physical Review B</i>.
    American Physical Society. <a href="https://doi.org/10.1103/PhysRevB.93.245404">https://doi.org/10.1103/PhysRevB.93.245404</a>
  chicago: Mishmash, Ryan, David Aasen, Andrew P Higginbotham, and Jason Alicea. “Approaching
    a Topological Phase Transition in Majorana Nanowires.” <i>Physical Review B</i>.
    American Physical Society, 2016. <a href="https://doi.org/10.1103/PhysRevB.93.245404">https://doi.org/10.1103/PhysRevB.93.245404</a>.
  ieee: R. Mishmash, D. Aasen, A. P. Higginbotham, and J. Alicea, “Approaching a topological
    phase transition in Majorana nanowires,” <i>Physical Review B</i>, vol. 93, no.
    24. American Physical Society, 2016.
  ista: Mishmash R, Aasen D, Higginbotham AP, Alicea J. 2016. Approaching a topological
    phase transition in Majorana nanowires. Physical Review B. 93(24), 245404.
  mla: Mishmash, Ryan, et al. “Approaching a Topological Phase Transition in Majorana
    Nanowires.” <i>Physical Review B</i>, vol. 93, no. 24, 245404, American Physical
    Society, 2016, doi:<a href="https://doi.org/10.1103/PhysRevB.93.245404">10.1103/PhysRevB.93.245404</a>.
  short: R. Mishmash, D. Aasen, A.P. Higginbotham, J. Alicea, Physical Review B 93
    (2016).
date_created: 2018-12-11T11:44:38Z
date_published: 2016-06-08T00:00:00Z
date_updated: 2021-01-12T06:47:42Z
day: '08'
doi: 10.1103/PhysRevB.93.245404
extern: '1'
external_id:
  arxiv:
  - '1601.07908'
intvolume: '        93'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1601.07908
month: '06'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_status: published
publisher: American Physical Society
publist_id: '7952'
quality_controlled: '1'
status: public
title: Approaching a topological phase transition in Majorana nanowires
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 93
year: '2016'
...
---
_id: '10376'
abstract:
- lang: eng
  text: Nucleation processes are at the heart of a large number of phenomena, from
    cloud formation to protein crystallization. A recently emerging area where nucleation
    is highly relevant is the initiation of filamentous protein self-assembly, a process
    that has broad implications in many research areas ranging from medicine to nanotechnology.
    As such, spontaneous nucleation of protein fibrils has received much attention
    in recent years with many theoretical and experimental studies focusing on the
    underlying physical principles. In this paper we make a step forward in this direction
    and explore the early time behaviour of filamentous protein growth in the context
    of nucleation theory. We first provide an overview of the thermodynamics and kinetics
    of spontaneous nucleation of protein filaments in the presence of one relevant
    degree of freedom, namely the cluster size. In this case, we review how key kinetic
    observables, such as the reaction order of spontaneous nucleation, are directly
    related to the physical size of the critical nucleus. We then focus on the increasingly
    prominent case of filament nucleation that includes a conformational conversion
    of the nucleating building-block as an additional slow step in the nucleation
    process. Using computer simulations, we study the concentration dependence of
    the nucleation rate. We find that, under these circumstances, the reaction order
    of spontaneous nucleation with respect to the free monomer does no longer relate
    to the overall physical size of the nucleating aggregate but rather to the portion
    of the aggregate that actively participates in the conformational conversion.
    Our results thus provide a novel interpretation of the common kinetic descriptors
    of protein filament formation, including the reaction order of the nucleation
    step or the scaling exponent of lag times, and put into perspective current theoretical
    descriptions of protein aggregation.
acknowledgement: We acknowledge support from the Human Frontier Science Program and
  Emmanuel College (A.Š.), St John’s and Peterhouse Colleges (T.C.T.M.), the Swiss
  National Science Foundation (T.C.T.M.), the Biotechnology and Biological Sciences
  Research Council (T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.),
  the European Research Council (T.C.T.M., T.P.J.K., and D.F.), and the Engineering
  and Physical Sciences Research Council (D.F.).
article_number: '211926'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Alessio
  full_name: Zaccone, Alessio
  last_name: Zaccone
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
- first_name: Daan
  full_name: Frenkel, Daan
  last_name: Frenkel
citation:
  ama: 'Šarić A, Michaels TCT, Zaccone A, Knowles TPJ, Frenkel D. Kinetics of spontaneous
    filament nucleation via oligomers: Insights from theory and simulation. <i>The
    Journal of Chemical Physics</i>. 2016;145(21). doi:<a href="https://doi.org/10.1063/1.4965040">10.1063/1.4965040</a>'
  apa: 'Šarić, A., Michaels, T. C. T., Zaccone, A., Knowles, T. P. J., &#38; Frenkel,
    D. (2016). Kinetics of spontaneous filament nucleation via oligomers: Insights
    from theory and simulation. <i>The Journal of Chemical Physics</i>. American Institute
    of Physics. <a href="https://doi.org/10.1063/1.4965040">https://doi.org/10.1063/1.4965040</a>'
  chicago: 'Šarić, Anđela, Thomas C. T. Michaels, Alessio Zaccone, Tuomas P. J. Knowles,
    and Daan Frenkel. “Kinetics of Spontaneous Filament Nucleation via Oligomers:
    Insights from Theory and Simulation.” <i>The Journal of Chemical Physics</i>.
    American Institute of Physics, 2016. <a href="https://doi.org/10.1063/1.4965040">https://doi.org/10.1063/1.4965040</a>.'
  ieee: 'A. Šarić, T. C. T. Michaels, A. Zaccone, T. P. J. Knowles, and D. Frenkel,
    “Kinetics of spontaneous filament nucleation via oligomers: Insights from theory
    and simulation,” <i>The Journal of Chemical Physics</i>, vol. 145, no. 21. American
    Institute of Physics, 2016.'
  ista: 'Šarić A, Michaels TCT, Zaccone A, Knowles TPJ, Frenkel D. 2016. Kinetics
    of spontaneous filament nucleation via oligomers: Insights from theory and simulation.
    The Journal of Chemical Physics. 145(21), 211926.'
  mla: 'Šarić, Anđela, et al. “Kinetics of Spontaneous Filament Nucleation via Oligomers:
    Insights from Theory and Simulation.” <i>The Journal of Chemical Physics</i>,
    vol. 145, no. 21, 211926, American Institute of Physics, 2016, doi:<a href="https://doi.org/10.1063/1.4965040">10.1063/1.4965040</a>.'
  short: A. Šarić, T.C.T. Michaels, A. Zaccone, T.P.J. Knowles, D. Frenkel, The Journal
    of Chemical Physics 145 (2016).
date_created: 2021-11-29T10:01:57Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2021-11-29T10:33:11Z
day: '01'
doi: 10.1063/1.4965040
extern: '1'
external_id:
  arxiv:
  - '1610.02320'
  pmid:
  - '28799382'
intvolume: '       145'
issue: '21'
keyword:
- physical and theoretical chemistry
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1610.02320
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
publication: The Journal of Chemical Physics
publication_identifier:
  eissn:
  - 1089-7690
  issn:
  - 0021-9606
publication_status: published
publisher: American Institute of Physics
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Kinetics of spontaneous filament nucleation via oligomers: Insights from theory
  and simulation'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 145
year: '2016'
...
---
_id: '10377'
abstract:
- lang: eng
  text: The interplay of membrane proteins is vital for many biological processes,
    such as cellular transport, cell division, and signal transduction between nerve
    cells. Theoretical considerations have led to the idea that the membrane itself
    mediates protein self-organization in these processes through minimization of
    membrane curvature energy. Here, we present a combined experimental and numerical
    study in which we quantify these interactions directly for the first time. In
    our experimental model system we control the deformation of a lipid membrane by
    adhering colloidal particles. Using confocal microscopy, we establish that these
    membrane deformations cause an attractive interaction force leading to reversible
    binding. The attraction extends over 2.5 times the particle diameter and has a
    strength of three times the thermal energy (−3.3 kBT). Coarse-grained Monte-Carlo
    simulations of the system are in excellent agreement with the experimental results
    and prove that the measured interaction is independent of length scale. Our combined
    experimental and numerical results reveal membrane curvature as a common physical
    origin for interactions between any membrane-deforming objects, from nanometre-sized
    proteins to micrometre-sized particles.
acknowledgement: This work was supported by the Netherlands Organisation for Scientific
  Research (NWO/OCW), as part of the Frontiers of Nanoscience program and VENI grant
  680-47-431. We thank Jeroen Appel and Wim Pomp for advice on the protocol design
  and Marcel Winter and Ruben Verweij for experimental support.
article_number: '32825'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Casper
  full_name: van der Wel, Casper
  last_name: van der Wel
- first_name: Afshin
  full_name: Vahid, Afshin
  last_name: Vahid
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Timon
  full_name: Idema, Timon
  last_name: Idema
- first_name: Doris
  full_name: Heinrich, Doris
  last_name: Heinrich
- first_name: Daniela J.
  full_name: Kraft, Daniela J.
  last_name: Kraft
citation:
  ama: van der Wel C, Vahid A, Šarić A, Idema T, Heinrich D, Kraft DJ. Lipid membrane-mediated
    attraction between curvature inducing objects. <i>Scientific Reports</i>. 2016;6(1).
    doi:<a href="https://doi.org/10.1038/srep32825">10.1038/srep32825</a>
  apa: van der Wel, C., Vahid, A., Šarić, A., Idema, T., Heinrich, D., &#38; Kraft,
    D. J. (2016). Lipid membrane-mediated attraction between curvature inducing objects.
    <i>Scientific Reports</i>. Springer Nature. <a href="https://doi.org/10.1038/srep32825">https://doi.org/10.1038/srep32825</a>
  chicago: Wel, Casper van der, Afshin Vahid, Anđela Šarić, Timon Idema, Doris Heinrich,
    and Daniela J. Kraft. “Lipid Membrane-Mediated Attraction between Curvature Inducing
    Objects.” <i>Scientific Reports</i>. Springer Nature, 2016. <a href="https://doi.org/10.1038/srep32825">https://doi.org/10.1038/srep32825</a>.
  ieee: C. van der Wel, A. Vahid, A. Šarić, T. Idema, D. Heinrich, and D. J. Kraft,
    “Lipid membrane-mediated attraction between curvature inducing objects,” <i>Scientific
    Reports</i>, vol. 6, no. 1. Springer Nature, 2016.
  ista: van der Wel C, Vahid A, Šarić A, Idema T, Heinrich D, Kraft DJ. 2016. Lipid
    membrane-mediated attraction between curvature inducing objects. Scientific Reports.
    6(1), 32825.
  mla: van der Wel, Casper, et al. “Lipid Membrane-Mediated Attraction between Curvature
    Inducing Objects.” <i>Scientific Reports</i>, vol. 6, no. 1, 32825, Springer Nature,
    2016, doi:<a href="https://doi.org/10.1038/srep32825">10.1038/srep32825</a>.
  short: C. van der Wel, A. Vahid, A. Šarić, T. Idema, D. Heinrich, D.J. Kraft, Scientific
    Reports 6 (2016).
date_created: 2021-11-29T10:34:08Z
date_published: 2016-09-13T00:00:00Z
date_updated: 2021-11-29T11:08:15Z
day: '13'
ddc:
- '540'
doi: 10.1038/srep32825
extern: '1'
external_id:
  arxiv:
  - '1603.04644'
  pmid:
  - '27618764'
file:
- access_level: open_access
  checksum: d6cf16dd511e15726b001e7cc287cf1d
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-11-29T10:50:00Z
  date_updated: 2021-11-29T10:50:00Z
  file_id: '10379'
  file_name: 2016_SciRep_vanderWel.pdf
  file_size: 1598289
  relation: main_file
  success: 1
file_date_updated: 2021-11-29T10:50:00Z
has_accepted_license: '1'
intvolume: '         6'
issue: '1'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.nature.com/articles/srep32825
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
  issn:
  - 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1038/srep37382
scopus_import: '1'
status: public
title: Lipid membrane-mediated attraction between curvature inducing objects
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 6
year: '2016'
...
---
_id: '10378'
abstract:
- lang: eng
  text: The ability of biological molecules to replicate themselves is the foundation
    of life, requiring a complex cellular machinery. However, a range of aberrant
    processes involve the self-replication of pathological protein structures without
    any additional assistance. One example is the autocatalytic generation of pathological
    protein aggregates, including amyloid fibrils, involved in neurodegenerative disorders.
    Here, we use computer simulations to identify the necessary requirements for the
    self-replication of fibrillar assemblies of proteins. We establish that a key
    physical determinant for this process is the affinity of proteins for the surfaces
    of fibrils. We find that self-replication can take place only in a very narrow
    regime of inter-protein interactions, implying a high level of sensitivity to
    system parameters and experimental conditions. We then compare our theoretical
    predictions with kinetic and biosensor measurements of fibrils formed from the
    Aβ peptide associated with Alzheimer’s disease. Our results show a quantitative
    connection between the kinetics of self-replication and the surface coverage of
    fibrils by monomeric proteins. These findings reveal the fundamental physical
    requirements for the formation of supra-molecular structures able to replicate
    themselves, and shed light on mechanisms in play in the proliferation of protein
    aggregates in nature.
acknowledgement: We acknowledge support from the Human Frontier Science Program and
  Emmanuel College (A.Š.), the Leverhulme Trust and Magdalene College (A.K.B.), St
  John’s College (T.C.T.M.), the Biotechnology and Biological Sciences Research Council
  (T.P.J.K. and C.M.D.), the Frances and Augustus Newman Foundation (T.P.J.K.), the
  European Research Council (T.P.J.K., T.C.T.M., S.L. and D.F.), and the Engineering
  and Physical Sciences Research Council (D.F.).
article_processing_charge: No
article_type: original
author:
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Alexander K.
  full_name: Buell, Alexander K.
  last_name: Buell
- first_name: Georg
  full_name: Meisl, Georg
  last_name: Meisl
- first_name: Thomas C. T.
  full_name: Michaels, Thomas C. T.
  last_name: Michaels
- first_name: Christopher M.
  full_name: Dobson, Christopher M.
  last_name: Dobson
- first_name: Sara
  full_name: Linse, Sara
  last_name: Linse
- first_name: Tuomas P. J.
  full_name: Knowles, Tuomas P. J.
  last_name: Knowles
- first_name: Daan
  full_name: Frenkel, Daan
  last_name: Frenkel
citation:
  ama: Šarić A, Buell AK, Meisl G, et al. Physical determinants of the self-replication
    of protein fibrils. <i>Nature Physics</i>. 2016;12(9):874-880. doi:<a href="https://doi.org/10.1038/nphys3828">10.1038/nphys3828</a>
  apa: Šarić, A., Buell, A. K., Meisl, G., Michaels, T. C. T., Dobson, C. M., Linse,
    S., … Frenkel, D. (2016). Physical determinants of the self-replication of protein
    fibrils. <i>Nature Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/nphys3828">https://doi.org/10.1038/nphys3828</a>
  chicago: Šarić, Anđela, Alexander K. Buell, Georg Meisl, Thomas C. T. Michaels,
    Christopher M. Dobson, Sara Linse, Tuomas P. J. Knowles, and Daan Frenkel. “Physical
    Determinants of the Self-Replication of Protein Fibrils.” <i>Nature Physics</i>.
    Springer Nature, 2016. <a href="https://doi.org/10.1038/nphys3828">https://doi.org/10.1038/nphys3828</a>.
  ieee: A. Šarić <i>et al.</i>, “Physical determinants of the self-replication of
    protein fibrils,” <i>Nature Physics</i>, vol. 12, no. 9. Springer Nature, pp.
    874–880, 2016.
  ista: Šarić A, Buell AK, Meisl G, Michaels TCT, Dobson CM, Linse S, Knowles TPJ,
    Frenkel D. 2016. Physical determinants of the self-replication of protein fibrils.
    Nature Physics. 12(9), 874–880.
  mla: Šarić, Anđela, et al. “Physical Determinants of the Self-Replication of Protein
    Fibrils.” <i>Nature Physics</i>, vol. 12, no. 9, Springer Nature, 2016, pp. 874–80,
    doi:<a href="https://doi.org/10.1038/nphys3828">10.1038/nphys3828</a>.
  short: A. Šarić, A.K. Buell, G. Meisl, T.C.T. Michaels, C.M. Dobson, S. Linse, T.P.J.
    Knowles, D. Frenkel, Nature Physics 12 (2016) 874–880.
date_created: 2021-11-29T10:36:11Z
date_published: 2016-07-18T00:00:00Z
date_updated: 2021-11-29T11:07:25Z
day: '18'
doi: 10.1038/nphys3828
extern: '1'
external_id:
  pmid:
  - '31031819'
intvolume: '        12'
issue: '9'
keyword:
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://discovery.ucl.ac.uk/id/eprint/1517406/
month: '07'
oa: 1
oa_version: Preprint
page: 874-880
pmid: 1
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Physical determinants of the self-replication of protein fibrils
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 12
year: '2016'
...
---
_id: '10380'
abstract:
- lang: eng
  text: Using non-equilibrium molecular dynamics simulations, it has been recently
    demonstrated that water molecules align in response to an imposed temperature
    gradient, resulting in an effective electric field. Here, we investigate how thermally
    induced fields depend on the underlying treatment of long-ranged interactions.
    For the short-ranged Wolf method and Ewald summation, we find the peak strength
    of the field to range between 2 × 107 and 5 × 107 V/m for a temperature gradient
    of 5.2 K/Å. Our value for the Wolf method is therefore an order of magnitude lower
    than the literature value [J. A. Armstrong and F. Bresme, J. Chem. Phys. 139,
    014504 (2013); J. Armstrong et al., J. Chem. Phys. 143, 036101 (2015)]. We show
    that this discrepancy can be traced back to the use of an incorrect kernel in
    the calculation of the electrostatic field. More seriously, we find that the Wolf
    method fails to predict correct molecular orientations, resulting in dipole densities
    with opposite sign to those computed using Ewald summation. By considering two
    different multipole expansions, we show that, for inhomogeneous polarisations,
    the quadrupole contribution can be significant and even outweigh the dipole contribution
    to the field. Finally, we propose a more accurate way of calculating the electrostatic
    potential and the field. In particular, we show that averaging the microscopic
    field analytically to obtain the macroscopic Maxwell field reduces the error bars
    by up to an order of magnitude. As a consequence, the simulation times required
    to reach a given statistical accuracy decrease by up to two orders of magnitude.
acknowledgement: The authors should like to dedicate this paper to the memory of Simon
  de Leeuw, who was a pioneer in the calculation of Coulomb effects in simulations.
  P.W. would like to thank the Austrian Academy of Sciences for financial support
  through a DOC Fellowship, and for covering the travel expenses for the CECAM workshop
  in Zaragoza in May 2015, where these results were first presented. P.W. would also
  like to thank Chao Zhang for pointing out the equivalence of the two expressions
  for the electric field discussed in Sec. VI D, Michiel Sprik for emphasising the
  importance of the quadrupole contribution in experimental studies of interfacial
  systems, as well as Aleks Reinhardt and other members of the Frenkel and Dellago
  groups for their advice. We further acknowledge support from the Federation of Austrian
  Industry (IV) Carinthia (P.W.), the University of Zagreb and Erasmus SMP (D. Fijan),
  the Human Frontier Science Program and Emmanuel College (A.Š.), the Austrian Science
  Fund FWF within the SFB Vicom project F41 (C.D.), and the Engineering and Physical
  Sciences Research Council Programme Grant No. EP/I001352/1 (D.F.). Additional data
  related to this publication are available at the University of Cambridge data repository
  (http://dx.doi.org/10.17863/CAM.118).
article_number: '224102'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: P.
  full_name: Wirnsberger, P.
  last_name: Wirnsberger
- first_name: D.
  full_name: Fijan, D.
  last_name: Fijan
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: M.
  full_name: Neumann, M.
  last_name: Neumann
- first_name: C.
  full_name: Dellago, C.
  last_name: Dellago
- first_name: D.
  full_name: Frenkel, D.
  last_name: Frenkel
citation:
  ama: Wirnsberger P, Fijan D, Šarić A, Neumann M, Dellago C, Frenkel D. Non-equilibrium
    simulations of thermally induced electric fields in water. <i>The Journal of Chemical
    Physics</i>. 2016;144(22). doi:<a href="https://doi.org/10.1063/1.4953036">10.1063/1.4953036</a>
  apa: Wirnsberger, P., Fijan, D., Šarić, A., Neumann, M., Dellago, C., &#38; Frenkel,
    D. (2016). Non-equilibrium simulations of thermally induced electric fields in
    water. <i>The Journal of Chemical Physics</i>. American Institute of Physics.
    <a href="https://doi.org/10.1063/1.4953036">https://doi.org/10.1063/1.4953036</a>
  chicago: Wirnsberger, P., D. Fijan, Anđela Šarić, M. Neumann, C. Dellago, and D.
    Frenkel. “Non-Equilibrium Simulations of Thermally Induced Electric Fields in
    Water.” <i>The Journal of Chemical Physics</i>. American Institute of Physics,
    2016. <a href="https://doi.org/10.1063/1.4953036">https://doi.org/10.1063/1.4953036</a>.
  ieee: P. Wirnsberger, D. Fijan, A. Šarić, M. Neumann, C. Dellago, and D. Frenkel,
    “Non-equilibrium simulations of thermally induced electric fields in water,” <i>The
    Journal of Chemical Physics</i>, vol. 144, no. 22. American Institute of Physics,
    2016.
  ista: Wirnsberger P, Fijan D, Šarić A, Neumann M, Dellago C, Frenkel D. 2016. Non-equilibrium
    simulations of thermally induced electric fields in water. The Journal of Chemical
    Physics. 144(22), 224102.
  mla: Wirnsberger, P., et al. “Non-Equilibrium Simulations of Thermally Induced Electric
    Fields in Water.” <i>The Journal of Chemical Physics</i>, vol. 144, no. 22, 224102,
    American Institute of Physics, 2016, doi:<a href="https://doi.org/10.1063/1.4953036">10.1063/1.4953036</a>.
  short: P. Wirnsberger, D. Fijan, A. Šarić, M. Neumann, C. Dellago, D. Frenkel, The
    Journal of Chemical Physics 144 (2016).
date_created: 2021-11-29T11:08:52Z
date_published: 2016-06-10T00:00:00Z
date_updated: 2021-11-29T13:09:08Z
day: '10'
doi: 10.1063/1.4953036
extern: '1'
external_id:
  arxiv:
  - '1602.02734'
  pmid:
  - '27305991'
intvolume: '       144'
issue: '22'
keyword:
- physical and theoretical chemistry
- general physics and astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1602.02734
month: '06'
oa: 1
oa_version: Preprint
pmid: 1
publication: The Journal of Chemical Physics
publication_identifier:
  eissn:
  - 1089-7690
  issn:
  - 0021-9606
publication_status: published
publisher: American Institute of Physics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-equilibrium simulations of thermally induced electric fields in water
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 144
year: '2016'
...
---
_id: '10381'
abstract:
- lang: eng
  text: We study phase behaviour of lipid-bilayer vesicles functionalised by ligand–receptor
    complexes made of synthetic DNA by introducing a modelling framework and a dedicated
    experimental platform. In particular, we perform Monte Carlo simulations that
    combine a coarse grained description of the lipid bilayer with state of art analytical
    models for multivalent ligand–receptor interactions. Using density of state calculations,
    we derive the partition function in pairs of vesicles and compute the number of
    ligand–receptor bonds as a function of temperature. Numerical results are compared
    to microscopy and fluorimetry experiments on large unilamellar vesicles decorated
    by DNA linkers carrying complementary overhangs. We find that vesicle aggregation
    is suppressed when the total number of linkers falls below a threshold value.
    Within the model proposed here, this is due to the higher configurational costs
    required to form inter-vesicle bridges as compared to intra-vesicle loops, which
    are in turn related to membrane deformability. Our findings and our numerical/experimental
    methodologies are applicable to the rational design of liposomes used as functional
    materials and drug delivery applications, as well as to study inter-membrane interactions
    in living systems, such as cell adhesion.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Stephan Jan
  full_name: Bachmann, Stephan Jan
  last_name: Bachmann
- first_name: Jurij
  full_name: Kotar, Jurij
  last_name: Kotar
- first_name: Lucia
  full_name: Parolini, Lucia
  last_name: Parolini
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Pietro
  full_name: Cicuta, Pietro
  last_name: Cicuta
- first_name: Lorenzo
  full_name: Di Michele, Lorenzo
  last_name: Di Michele
- first_name: Bortolo Matteo
  full_name: Mognetti, Bortolo Matteo
  last_name: Mognetti
citation:
  ama: Bachmann SJ, Kotar J, Parolini L, et al. Melting transition in lipid vesicles
    functionalised by mobile DNA linkers. <i>Soft Matter</i>. 2016;12(37):7804-7817.
    doi:<a href="https://doi.org/10.1039/c6sm01515h">10.1039/c6sm01515h</a>
  apa: Bachmann, S. J., Kotar, J., Parolini, L., Šarić, A., Cicuta, P., Di Michele,
    L., &#38; Mognetti, B. M. (2016). Melting transition in lipid vesicles functionalised
    by mobile DNA linkers. <i>Soft Matter</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/c6sm01515h">https://doi.org/10.1039/c6sm01515h</a>
  chicago: Bachmann, Stephan Jan, Jurij Kotar, Lucia Parolini, Anđela Šarić, Pietro
    Cicuta, Lorenzo Di Michele, and Bortolo Matteo Mognetti. “Melting Transition in
    Lipid Vesicles Functionalised by Mobile DNA Linkers.” <i>Soft Matter</i>. Royal
    Society of Chemistry, 2016. <a href="https://doi.org/10.1039/c6sm01515h">https://doi.org/10.1039/c6sm01515h</a>.
  ieee: S. J. Bachmann <i>et al.</i>, “Melting transition in lipid vesicles functionalised
    by mobile DNA linkers,” <i>Soft Matter</i>, vol. 12, no. 37. Royal Society of
    Chemistry, pp. 7804–7817, 2016.
  ista: Bachmann SJ, Kotar J, Parolini L, Šarić A, Cicuta P, Di Michele L, Mognetti
    BM. 2016. Melting transition in lipid vesicles functionalised by mobile DNA linkers.
    Soft Matter. 12(37), 7804–7817.
  mla: Bachmann, Stephan Jan, et al. “Melting Transition in Lipid Vesicles Functionalised
    by Mobile DNA Linkers.” <i>Soft Matter</i>, vol. 12, no. 37, Royal Society of
    Chemistry, 2016, pp. 7804–17, doi:<a href="https://doi.org/10.1039/c6sm01515h">10.1039/c6sm01515h</a>.
  short: S.J. Bachmann, J. Kotar, L. Parolini, A. Šarić, P. Cicuta, L. Di Michele,
    B.M. Mognetti, Soft Matter 12 (2016) 7804–7817.
date_created: 2021-11-29T11:09:55Z
date_published: 2016-08-19T00:00:00Z
date_updated: 2021-11-29T13:09:00Z
day: '19'
doi: 10.1039/c6sm01515h
extern: '1'
external_id:
  arxiv:
  - '1608.05788'
  pmid:
  - '27722701'
intvolume: '        12'
issue: '37'
keyword:
- condensed matter physics
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1608.05788
month: '08'
oa: 1
oa_version: Preprint
page: 7804-7817
pmid: 1
publication: Soft Matter
publication_identifier:
  eissn:
  - 1744-6848
  issn:
  - 1744-683X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Melting transition in lipid vesicles functionalised by mobile DNA linkers
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 12
year: '2016'
...
---
_id: '1057'
abstract:
- lang: eng
  text: Far-field super-resolution fluorescence microscopy discerns fluorophores residing
    closer than the diffraction barrier by briefly transferring them in different
    (typically ON and OFF) states before detection. In coordinate-targeted super-resolution
    variants, such as stimulated emission depletion (STED) microscopy, this state
    difference is created by the intensity minima and maxima of an optical pattern,
    causing all fluorophores to assume the off state, for instance, except at the
    minima. Although strong spatial confinement of the on state enables high resolution,
    it also subjects the fluorophores to excess intensities and state cycles at the
    maxima. Here, we address these issues by driving the fluorophores into a second
    off state that is inert to the excess light. By using reversibly switchable fluorescent
    proteins as labels, our approach reduces bleaching and enhances resolution and
    contrast in live-cell STED microscopy. Using two or more transitions to off states
    is a useful strategy for augmenting the power of coordinate-targeted super-resolution
    microscopy.
acknowledgement: We thank T. Gilat and E. Rothermel (both MPI) for help with preparing
  samples, and J. Keller for discussion. J.G.D. acknowledges support by the European
  Union through a Marie Curie fellowship PIEF-GA-2011-299283. S.W.H. acknowledges
  support by the Körber Foundation.
article_processing_charge: No
author:
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Sven
  full_name: Sidenstein, Sven
  last_name: Sidenstein
- first_name: Carola
  full_name: Gregor, Carola
  last_name: Gregor
- first_name: Nicolai
  full_name: Urban, Nicolai
  last_name: Urban
- first_name: Peter
  full_name: Ilgen, Peter
  last_name: Ilgen
- first_name: Stefan
  full_name: Jakobs, Stefan
  last_name: Jakobs
- first_name: Stefan
  full_name: Hell, Stefan
  last_name: Hell
citation:
  ama: Danzl JG, Sidenstein S, Gregor C, et al. Coordinate-targeted fluorescence nanoscopy
    with multiple off states. <i>Nature Photonics</i>. 2016;10(2):122-128. doi:<a
    href="https://doi.org/10.1038/nphoton.2015.266">10.1038/nphoton.2015.266</a>
  apa: Danzl, J. G., Sidenstein, S., Gregor, C., Urban, N., Ilgen, P., Jakobs, S.,
    &#38; Hell, S. (2016). Coordinate-targeted fluorescence nanoscopy with multiple
    off states. <i>Nature Photonics</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nphoton.2015.266">https://doi.org/10.1038/nphoton.2015.266</a>
  chicago: Danzl, Johann G, Sven Sidenstein, Carola Gregor, Nicolai Urban, Peter Ilgen,
    Stefan Jakobs, and Stefan Hell. “Coordinate-Targeted Fluorescence Nanoscopy with
    Multiple off States.” <i>Nature Photonics</i>. Nature Publishing Group, 2016.
    <a href="https://doi.org/10.1038/nphoton.2015.266">https://doi.org/10.1038/nphoton.2015.266</a>.
  ieee: J. G. Danzl <i>et al.</i>, “Coordinate-targeted fluorescence nanoscopy with
    multiple off states,” <i>Nature Photonics</i>, vol. 10, no. 2. Nature Publishing
    Group, pp. 122–128, 2016.
  ista: Danzl JG, Sidenstein S, Gregor C, Urban N, Ilgen P, Jakobs S, Hell S. 2016.
    Coordinate-targeted fluorescence nanoscopy with multiple off states. Nature Photonics.
    10(2), 122–128.
  mla: Danzl, Johann G., et al. “Coordinate-Targeted Fluorescence Nanoscopy with Multiple
    off States.” <i>Nature Photonics</i>, vol. 10, no. 2, Nature Publishing Group,
    2016, pp. 122–28, doi:<a href="https://doi.org/10.1038/nphoton.2015.266">10.1038/nphoton.2015.266</a>.
  short: J.G. Danzl, S. Sidenstein, C. Gregor, N. Urban, P. Ilgen, S. Jakobs, S. Hell,
    Nature Photonics 10 (2016) 122–128.
date_created: 2018-12-11T11:49:55Z
date_published: 2016-02-01T00:00:00Z
date_updated: 2021-01-12T06:47:58Z
day: '01'
doi: 10.1038/nphoton.2015.266
extern: '1'
intvolume: '        10'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 122 - 128
publication: Nature Photonics
publication_status: published
publisher: Nature Publishing Group
publist_id: '6331'
status: public
title: Coordinate-targeted fluorescence nanoscopy with multiple off states
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2016'
...
---
_id: '1059'
abstract:
- lang: eng
  text: A range of bright and photostable rhodamines and carbopyronines with absorption
    maxima in the range of λ=500-630 nm were prepared, and enabled the specific labeling
    of cytoskeletal filaments using HaloTag technology followed by staining with 1
    μm solutions of the dye-ligand conjugates. The synthesis, photophysical parameters,
    fluorogenic behavior, and structure-property relationships of the new dyes are
    discussed. Light microscopy with stimulated emission depletion (STED) provided
    one- and two-color images of living cells with an optical resolution of 40-60
    nm.
acknowledgement: We thank Prof. Y. Okada (RIKEN Quantitative Biology Center, Osaka,
  Japan) for the gift of β-tubulin-Halo plasmid, T. Gilat and Dr. E. Rothermel (MPIBPC,
  Göttingen, Germany) for cell culture and transfection, M. Pulst, J. Bienert (MPIBPC),
  Dr. M. John, Dr. H. Frauendorf, and co-workers (Institut für Organische und Biomolekulare
  Chemie, Georg-August-Universität, Göttingen, Germany) for UV/Vis, NMR, and ESI-MS
  spectra, Prof. M. L. Bossi (University of Buenos-Aires, Argentina) for measuring
  fluorescence lifetimes, and Dr. S. Vos and Prof. P. Cramer (MPIBPC) for access to
  a Tecan microplate reader. S.W.H. acknowledges a grant from the Bundesministerium
  für Bildung und Forschung (BMBF 513) within the program “Optische Technologien für
  Biowissenschaften und Gesundheit” (FKZ 13N11066). J.G.D. was supported by funds
  from the People Programme (Marie Curie Actions) of the European Union's Seventh
  Framework Programme (FP7/2007–2013; REA grant agreement PIEF-GA-2011-299283).
article_processing_charge: No
author:
- first_name: Alexey
  full_name: Butkevich, Alexey
  last_name: Butkevich
- first_name: Gyuzel
  full_name: Mitronova, Gyuzel
  last_name: Mitronova
- first_name: Sven
  full_name: Sidenstein, Sven
  last_name: Sidenstein
- first_name: Jessica
  full_name: Klocke, Jessica
  last_name: Klocke
- first_name: Dirk
  full_name: Kamin, Dirk
  last_name: Kamin
- first_name: Dirk
  full_name: Meineke, Dirk
  last_name: Meineke
- first_name: Elisa
  full_name: D'Este, Elisa
  last_name: D'Este
- first_name: Philip
  full_name: Kraemer, Philip
  last_name: Kraemer
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Vladimir
  full_name: Belov, Vladimir
  last_name: Belov
- first_name: Stefan
  full_name: Hell, Stefan
  last_name: Hell
citation:
  ama: Butkevich A, Mitronova G, Sidenstein S, et al. Fluorescent rhodamines and fluorogenic
    carbopyronines for super-resolution STED microscopy in living cells. <i>Angewandte
    Chemie - International Edition</i>. 2016;55(10):3290-3294. doi:<a href="https://doi.org/10.1002/anie.201511018">10.1002/anie.201511018</a>
  apa: Butkevich, A., Mitronova, G., Sidenstein, S., Klocke, J., Kamin, D., Meineke,
    D., … Hell, S. (2016). Fluorescent rhodamines and fluorogenic carbopyronines for
    super-resolution STED microscopy in living cells. <i>Angewandte Chemie - International
    Edition</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/anie.201511018">https://doi.org/10.1002/anie.201511018</a>
  chicago: Butkevich, Alexey, Gyuzel Mitronova, Sven Sidenstein, Jessica Klocke, Dirk
    Kamin, Dirk Meineke, Elisa D’Este, et al. “Fluorescent Rhodamines and Fluorogenic
    Carbopyronines for Super-Resolution STED Microscopy in Living Cells.” <i>Angewandte
    Chemie - International Edition</i>. Wiley-Blackwell, 2016. <a href="https://doi.org/10.1002/anie.201511018">https://doi.org/10.1002/anie.201511018</a>.
  ieee: A. Butkevich <i>et al.</i>, “Fluorescent rhodamines and fluorogenic carbopyronines
    for super-resolution STED microscopy in living cells,” <i>Angewandte Chemie -
    International Edition</i>, vol. 55, no. 10. Wiley-Blackwell, pp. 3290–3294, 2016.
  ista: Butkevich A, Mitronova G, Sidenstein S, Klocke J, Kamin D, Meineke D, D’Este
    E, Kraemer P, Danzl JG, Belov V, Hell S. 2016. Fluorescent rhodamines and fluorogenic
    carbopyronines for super-resolution STED microscopy in living cells. Angewandte
    Chemie - International Edition. 55(10), 3290–3294.
  mla: Butkevich, Alexey, et al. “Fluorescent Rhodamines and Fluorogenic Carbopyronines
    for Super-Resolution STED Microscopy in Living Cells.” <i>Angewandte Chemie -
    International Edition</i>, vol. 55, no. 10, Wiley-Blackwell, 2016, pp. 3290–94,
    doi:<a href="https://doi.org/10.1002/anie.201511018">10.1002/anie.201511018</a>.
  short: A. Butkevich, G. Mitronova, S. Sidenstein, J. Klocke, D. Kamin, D. Meineke,
    E. D’Este, P. Kraemer, J.G. Danzl, V. Belov, S. Hell, Angewandte Chemie - International
    Edition 55 (2016) 3290–3294.
date_created: 2018-12-11T11:49:55Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2021-01-12T06:47:59Z
day: '01'
doi: 10.1002/anie.201511018
extern: '1'
intvolume: '        55'
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa_version: None
page: 3290 - 3294
publication: Angewandte Chemie - International Edition
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6330'
status: public
title: Fluorescent rhodamines and fluorogenic carbopyronines for super-resolution
  STED microscopy in living cells
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2016'
...
---
_id: '1060'
abstract:
- lang: eng
  text: Superresolution fluorescence microscopy of multiple fluorophores still requires
    development. Here we present simultaneous three-colour stimulated emission depletion
    (STED) nanoscopy relying on a single STED beam at 620 nm. Toggling the STED beam
    between two or more power levels (&quot;multilevelSTEDv) optimizes resolution
    and contrast in all colour channels, which are intrinsically co-aligned and well
    separated. Three-colour recording is demonstrated by imaging the nanoscale cytoskeletal
    organization in cultured hippocampal neurons. The down to ∼35 nm resolution identified
    periodic actin/betaII spectrin lattices along dendrites and spines; however, at
    presynaptic and postsynaptic sites, these patterns were found to be absent. Both
    our multicolour scheme and the 620 nm STED line should be attractive for routine
    STED microscopy applications.
acknowledgement: We acknowledge the assistance of I. Herfort with neuron preparation,
  and of J. Bienert and K. Müller with analyses of the dye 540R derivatives. We thank
  T. Gilat and E. Rothermel for sample preparation as well as J. Keller, F. Winter
  (all MPI-BPC) and C.A. Wurm (Abberior Instruments) for helpful discussion, and S.J.
  Sahl (MPI-BPC) for a critical reading of the manuscript.
article_processing_charge: No
author:
- first_name: Sven
  full_name: Sidenstein, Sven
  last_name: Sidenstein
- first_name: Elisa
  full_name: D'Este, Elisa
  last_name: D'Este
- first_name: Marvin
  full_name: Böhm, Marvin
  last_name: Böhm
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Vladimir
  full_name: Belov, Vladimir
  last_name: Belov
- first_name: Stefan
  full_name: Hell, Stefan
  last_name: Hell
citation:
  ama: Sidenstein S, D’Este E, Böhm M, Danzl JG, Belov V, Hell S. Multicolour multilevel
    STED nanoscopy of actin/spectrin organization at synapses. <i>Scientific Reports</i>.
    2016;6:1-8. doi:<a href="https://doi.org/10.1038/srep26725">10.1038/srep26725</a>
  apa: Sidenstein, S., D’Este, E., Böhm, M., Danzl, J. G., Belov, V., &#38; Hell,
    S. (2016). Multicolour multilevel STED nanoscopy of actin/spectrin organization
    at synapses. <i>Scientific Reports</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/srep26725">https://doi.org/10.1038/srep26725</a>
  chicago: Sidenstein, Sven, Elisa D’Este, Marvin Böhm, Johann G Danzl, Vladimir Belov,
    and Stefan Hell. “Multicolour Multilevel STED Nanoscopy of Actin/Spectrin Organization
    at Synapses.” <i>Scientific Reports</i>. Nature Publishing Group, 2016. <a href="https://doi.org/10.1038/srep26725">https://doi.org/10.1038/srep26725</a>.
  ieee: S. Sidenstein, E. D’Este, M. Böhm, J. G. Danzl, V. Belov, and S. Hell, “Multicolour
    multilevel STED nanoscopy of actin/spectrin organization at synapses,” <i>Scientific
    Reports</i>, vol. 6. Nature Publishing Group, pp. 1–8, 2016.
  ista: Sidenstein S, D’Este E, Böhm M, Danzl JG, Belov V, Hell S. 2016. Multicolour
    multilevel STED nanoscopy of actin/spectrin organization at synapses. Scientific
    Reports. 6, 1–8.
  mla: Sidenstein, Sven, et al. “Multicolour Multilevel STED Nanoscopy of Actin/Spectrin
    Organization at Synapses.” <i>Scientific Reports</i>, vol. 6, Nature Publishing
    Group, 2016, pp. 1–8, doi:<a href="https://doi.org/10.1038/srep26725">10.1038/srep26725</a>.
  short: S. Sidenstein, E. D’Este, M. Böhm, J.G. Danzl, V. Belov, S. Hell, Scientific
    Reports 6 (2016) 1–8.
date_created: 2018-12-11T11:49:56Z
date_published: 2016-05-25T00:00:00Z
date_updated: 2021-01-12T06:47:59Z
day: '25'
doi: 10.1038/srep26725
extern: '1'
intvolume: '         6'
language:
- iso: eng
month: '05'
oa_version: None
page: 1 - 8
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6329'
status: public
title: Multicolour multilevel STED nanoscopy of actin/spectrin organization at synapses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2016'
...
---
_id: '1068'
abstract:
- lang: eng
  text: 'Games on graphs provide the appropriate framework to study several central
    problems in computer science, such as verification and synthesis of reactive systems.
    One of the most basic objectives for games on graphs is the liveness (or Büchi)
    objective that given a target set of vertices requires that some vertex in the
    target set is visited infinitely often. We study generalized Büchi objectives
    (i.e., conjunction of liveness objectives), and implications between two generalized
    Büchi objectives (known as GR(1) objectives), that arise in numerous applications
    in computer-aided verification. We present improved algorithms and conditional
    super-linear lower bounds based on widely believed assumptions about the complexity
    of (A1) combinatorial Boolean matrix multiplication and (A2) CNF-SAT. We consider
    graph games with n vertices, m edges, and generalized Büchi objectives with k
    conjunctions. First, we present an algorithm with running time O(k*n^2), improving
    the previously known O(k*n*m) and O(k^2*n^2) worst-case bounds. Our algorithm
    is optimal for dense graphs under (A1). Second, we show that the basic algorithm
    for the problem is optimal for sparse graphs when the target sets have constant
    size under (A2). Finally, we consider GR(1) objectives, with k_1 conjunctions
    in the antecedent and k_2 conjunctions in the consequent, and present an O(k_1
    k_2 n^{2.5})-time algorithm, improving the previously known O(k_1*k_2*n*m)-time
    algorithm for m &gt; n^{1.5}. '
acknowledgement: K. C., M. H., and W. D. are partially supported by the Vienna Science
  and Technology Fund (WWTF) through project ICT15-003. K. C. is partially supported
  by the Austrian Science Fund (FWF) NFN Grant No S11407-N23 (RiSE/SHiNE) and an ERC
  Start grant (279307
alternative_title:
- LIPIcs
article_number: '25'
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Wolfgang
  full_name: Dvorák, Wolfgang
  last_name: Dvorák
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Veronika
  full_name: Loitzenbauer, Veronika
  last_name: Loitzenbauer
citation:
  ama: 'Chatterjee K, Dvorák W, Henzinger MH, Loitzenbauer V. Conditionally optimal
    algorithms for generalized Büchi Games. In: Vol 58. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPIcs.MFCS.2016.25">10.4230/LIPIcs.MFCS.2016.25</a>'
  apa: 'Chatterjee, K., Dvorák, W., Henzinger, M. H., &#38; Loitzenbauer, V. (2016).
    Conditionally optimal algorithms for generalized Büchi Games (Vol. 58). Presented
    at the MFCS: Mathematical Foundations of Computer Science (SG), Krakow, Poland:
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.MFCS.2016.25">https://doi.org/10.4230/LIPIcs.MFCS.2016.25</a>'
  chicago: Chatterjee, Krishnendu, Wolfgang Dvorák, Monika H Henzinger, and Veronika
    Loitzenbauer. “Conditionally Optimal Algorithms for Generalized Büchi Games,”
    Vol. 58. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016. <a href="https://doi.org/10.4230/LIPIcs.MFCS.2016.25">https://doi.org/10.4230/LIPIcs.MFCS.2016.25</a>.
  ieee: 'K. Chatterjee, W. Dvorák, M. H. Henzinger, and V. Loitzenbauer, “Conditionally
    optimal algorithms for generalized Büchi Games,” presented at the MFCS: Mathematical
    Foundations of Computer Science (SG), Krakow, Poland, 2016, vol. 58.'
  ista: 'Chatterjee K, Dvorák W, Henzinger MH, Loitzenbauer V. 2016. Conditionally
    optimal algorithms for generalized Büchi Games. MFCS: Mathematical Foundations
    of Computer Science (SG), LIPIcs, vol. 58, 25.'
  mla: Chatterjee, Krishnendu, et al. <i>Conditionally Optimal Algorithms for Generalized
    Büchi Games</i>. Vol. 58, 25, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2016, doi:<a href="https://doi.org/10.4230/LIPIcs.MFCS.2016.25">10.4230/LIPIcs.MFCS.2016.25</a>.
  short: K. Chatterjee, W. Dvorák, M.H. Henzinger, V. Loitzenbauer, in:, Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2016.
conference:
  end_date: 2016-08-26
  location: Krakow, Poland
  name: 'MFCS: Mathematical Foundations of Computer Science (SG)'
  start_date: 2016-08-22
date_created: 2018-12-11T11:49:58Z
date_published: 2016-08-01T00:00:00Z
date_updated: 2025-06-02T08:53:50Z
day: '01'
ddc:
- '000'
- '004'
- '006'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.MFCS.2016.25
ec_funded: 1
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:02Z
  date_updated: 2018-12-12T10:16:02Z
  file_id: '5187'
  file_name: IST-2017-779-v1+1_LIPIcs-MFCS-2016-25.pdf
  file_size: 632786
  relation: main_file
file_date_updated: 2018-12-12T10:16:02Z
has_accepted_license: '1'
intvolume: '        58'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '6317'
pubrep_id: '779'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Conditionally optimal algorithms for generalized Büchi Games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2016'
...
---
_id: '1069'
abstract:
- lang: eng
  text: "The Continuous Skolem Problem asks whether a real-valued function satisfying
    a linear differen-\r\ntial equation has a zero in a given interval of real numbers.
    This is a fundamental reachability\r\nproblem for continuous linear dynamical
    systems, such as linear hybrid automata and continuous-\r\ntime Markov chains.
    Decidability of the problem is currently open – indeed decidability is open\r\neven
    for the sub-problem in which a zero is sought in a bounded interval. In this paper
    we show\r\ndecidability of the bounded problem subject to Schanuel’s Conjecture,
    a unifying conjecture in\r\ntranscendental number theory. We furthermore analyse
    the unbounded problem in terms of the\r\nfrequencies of the differential equation,
    that is, the imaginary parts of the characteristic roots.\r\nWe show that the
    unbounded problem can be reduced to the bounded problem if there is at most\r\none
    rationally linearly independent frequency, or if there are two rationally linearly
    independent\r\nfrequencies and all characteristic roots are simple. We complete
    the picture by showing that de-\r\ncidability of the unbounded problem in the
    case of two (or more) rationally linearly independent\r\nfrequencies would entail
    a major new effectiveness result in Diophantine approximation, namely\r\ncomputability
    of the Diophantine-approximation types of all real algebraic numbers."
acknowledgement: 'Ventsislav Chonev is supported by Austrian Science Fund (FWF) NFN
  Grant No S11407-N23 (RiSE/SHiNE), ERC Start grant (279307:  Graph Games), and ERC
  Advanced Grant (267989: QUAREM).'
alternative_title:
- LIPIcs
article_number: '100'
author:
- first_name: Ventsislav K
  full_name: Chonev, Ventsislav K
  id: 36CBE2E6-F248-11E8-B48F-1D18A9856A87
  last_name: Chonev
- first_name: Joël
  full_name: Ouaknine, Joël
  last_name: Ouaknine
- first_name: James
  full_name: Worrell, James
  last_name: Worrell
citation:
  ama: 'Chonev VK, Ouaknine J, Worrell J. On the skolem problem for continuous linear
    dynamical systems. In: Vol 55. Schloss Dagstuhl- Leibniz-Zentrum fur Informatik;
    2016. doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.100">10.4230/LIPIcs.ICALP.2016.100</a>'
  apa: 'Chonev, V. K., Ouaknine, J., &#38; Worrell, J. (2016). On the skolem problem
    for continuous linear dynamical systems (Vol. 55). Presented at the ICALP: Automata,
    Languages and Programming, Rome, Italy: Schloss Dagstuhl- Leibniz-Zentrum fur
    Informatik. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.100">https://doi.org/10.4230/LIPIcs.ICALP.2016.100</a>'
  chicago: Chonev, Ventsislav K, Joël Ouaknine, and James Worrell. “On the Skolem
    Problem for Continuous Linear Dynamical Systems,” Vol. 55. Schloss Dagstuhl- Leibniz-Zentrum
    fur Informatik, 2016. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.100">https://doi.org/10.4230/LIPIcs.ICALP.2016.100</a>.
  ieee: 'V. K. Chonev, J. Ouaknine, and J. Worrell, “On the skolem problem for continuous
    linear dynamical systems,” presented at the ICALP: Automata, Languages and Programming,
    Rome, Italy, 2016, vol. 55.'
  ista: 'Chonev VK, Ouaknine J, Worrell J. 2016. On the skolem problem for continuous
    linear dynamical systems. ICALP: Automata, Languages and Programming, LIPIcs,
    vol. 55, 100.'
  mla: Chonev, Ventsislav K., et al. <i>On the Skolem Problem for Continuous Linear
    Dynamical Systems</i>. Vol. 55, 100, Schloss Dagstuhl- Leibniz-Zentrum fur Informatik,
    2016, doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.100">10.4230/LIPIcs.ICALP.2016.100</a>.
  short: V.K. Chonev, J. Ouaknine, J. Worrell, in:, Schloss Dagstuhl- Leibniz-Zentrum
    fur Informatik, 2016.
conference:
  end_date: 2016-07-15
  location: Rome, Italy
  name: 'ICALP: Automata, Languages and Programming'
  start_date: 2016-07-12
date_created: 2018-12-11T11:49:59Z
date_published: 2016-08-01T00:00:00Z
date_updated: 2021-01-12T06:48:03Z
day: '01'
ddc:
- '004'
- '006'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.ICALP.2016.100
ec_funded: 1
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:26Z
  date_updated: 2018-12-12T10:16:26Z
  file_id: '5213'
  file_name: IST-2017-778-v1+1_LIPIcs-ICALP-2016-100.pdf
  file_size: 521415
  relation: main_file
file_date_updated: 2018-12-12T10:16:26Z
has_accepted_license: '1'
intvolume: '        55'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '267989'
  name: Quantitative Reactive Modeling
publication_status: published
publisher: Schloss Dagstuhl- Leibniz-Zentrum fur Informatik
publist_id: '6314'
pubrep_id: '778'
quality_controlled: '1'
scopus_import: 1
status: public
title: On the skolem problem for continuous linear dynamical systems
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2016'
...
---
_id: '1070'
abstract:
- lang: eng
  text: 'We present a logic that extends CTL (Computation Tree Logic) with operators
    that express synchronization properties. A property is synchronized in a system
    if it holds in all paths of a certain length. The new logic is obtained by using
    the same path quantifiers and temporal operators as in CTL, but allowing a different
    order of the quantifiers. This small syntactic variation induces a logic that
    can express non-regular properties for which known extensions of MSO with equality
    of path length are undecidable. We show that our variant of CTL is decidable and
    that the model-checking problem is in Delta_3^P = P^{NP^NP}, and is DP-hard. We
    analogously consider quantifier exchange in extensions of CTL, and we present
    operators defined using basic operators of CTL* that express the occurrence of
    infinitely many synchronization points. We show that the model-checking problem
    remains in Delta_3^P. The distinguishing power of CTL and of our new logic coincide
    if the Next operator is allowed in the logics, thus the classical bisimulation
    quotient can be used for state-space reduction before model checking. '
acknowledgement: "This research was partially supported by Austrian Science Fund (FWF)
  NFN Grant No S11407-N23 (RiSE/SHiNE), ERC Start grant (279307: Graph Games), Vienna
  Science and Technology Fund (WWTF) through project ICT15-003, and European project
  Cassting (FP7-601148).\r\n\r\nWe thank Stefan Göller and anonymous reviewers for
  their insightful\r\ncomments and suggestions.\r\n"
alternative_title:
- LIPIcs
article_number: '98'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
citation:
  ama: 'Chatterjee K, Doyen L. Computation tree logic for synchronization properties.
    In: Vol 55. Schloss Dagstuhl- Leibniz-Zentrum fur Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.98">10.4230/LIPIcs.ICALP.2016.98</a>'
  apa: 'Chatterjee, K., &#38; Doyen, L. (2016). Computation tree logic for synchronization
    properties (Vol. 55). Presented at the ICALP: Automata, Languages and Programming,
    Rome, Italy: Schloss Dagstuhl- Leibniz-Zentrum fur Informatik. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.98">https://doi.org/10.4230/LIPIcs.ICALP.2016.98</a>'
  chicago: Chatterjee, Krishnendu, and Laurent Doyen. “Computation Tree Logic for
    Synchronization Properties,” Vol. 55. Schloss Dagstuhl- Leibniz-Zentrum fur Informatik,
    2016. <a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.98">https://doi.org/10.4230/LIPIcs.ICALP.2016.98</a>.
  ieee: 'K. Chatterjee and L. Doyen, “Computation tree logic for synchronization properties,”
    presented at the ICALP: Automata, Languages and Programming, Rome, Italy, 2016,
    vol. 55.'
  ista: 'Chatterjee K, Doyen L. 2016. Computation tree logic for synchronization properties.
    ICALP: Automata, Languages and Programming, LIPIcs, vol. 55, 98.'
  mla: Chatterjee, Krishnendu, and Laurent Doyen. <i>Computation Tree Logic for Synchronization
    Properties</i>. Vol. 55, 98, Schloss Dagstuhl- Leibniz-Zentrum fur Informatik,
    2016, doi:<a href="https://doi.org/10.4230/LIPIcs.ICALP.2016.98">10.4230/LIPIcs.ICALP.2016.98</a>.
  short: K. Chatterjee, L. Doyen, in:, Schloss Dagstuhl- Leibniz-Zentrum fur Informatik,
    2016.
conference:
  end_date: 2016-07-15
  location: Rome, Italy
  name: 'ICALP: Automata, Languages and Programming'
  start_date: 2016-07-12
date_created: 2018-12-11T11:49:59Z
date_published: 2016-01-01T00:00:00Z
date_updated: 2021-01-12T06:48:03Z
day: '01'
ddc:
- '005'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.ICALP.2016.98
ec_funded: 1
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:52Z
  date_updated: 2018-12-12T10:08:52Z
  file_id: '4714'
  file_name: IST-2017-812-v1+1_LIPIcs-ICALP-2016-98.pdf
  file_size: 546133
  relation: main_file
file_date_updated: 2018-12-12T10:08:52Z
has_accepted_license: '1'
intvolume: '        55'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
publication_status: published
publisher: Schloss Dagstuhl- Leibniz-Zentrum fur Informatik
publist_id: '6313'
pubrep_id: '812'
quality_controlled: '1'
scopus_import: 1
status: public
title: Computation tree logic for synchronization properties
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2016'
...
---
_id: '1071'
abstract:
- lang: eng
  text: 'We consider data-structures for answering reachability and distance queries
    on constant-treewidth graphs with n nodes, on the standard RAM computational model
    with wordsize W=Theta(log n). Our first contribution is a data-structure that
    after O(n) preprocessing time, allows (1) pair reachability queries in O(1) time;
    and (2) single-source reachability queries in O(n/log n) time. This is (asymptotically)
    optimal and is faster than DFS/BFS when answering more than a constant number
    of single-source queries. The data-structure uses at all times O(n) space. Our
    second contribution is a space-time tradeoff data-structure for distance queries.
    For any epsilon in [1/2,1], we provide a data-structure with polynomial preprocessing
    time that allows pair queries in O(n^{1-\epsilon} alpha(n)) time, where alpha
    is the inverse of the Ackermann function, and at all times uses O(n^epsilon) space.
    The input graph G is not considered in the space complexity. '
acknowledgement: 'The research was partly supported by Austrian Science Fund (FWF)
  Grant No P23499-N23, FWF NFN Grant No S11407-N23 (RiSE/SHiNE) and ERC Start grant
  (279307: Graph Games).'
alternative_title:
- LIPIcs
article_number: '28'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Andreas
  full_name: Pavlogiannis, Andreas
  id: 49704004-F248-11E8-B48F-1D18A9856A87
  last_name: Pavlogiannis
  orcid: 0000-0002-8943-0722
citation:
  ama: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Optimal reachability and a space
    time tradeoff for distance queries in constant treewidth graphs. In: Vol 57. Schloss
    Dagstuhl- Leibniz-Zentrum fur Informatik; 2016. doi:<a href="https://doi.org/10.4230/LIPIcs.ESA.2016.28">10.4230/LIPIcs.ESA.2016.28</a>'
  apa: 'Chatterjee, K., Ibsen-Jensen, R., &#38; Pavlogiannis, A. (2016). Optimal reachability
    and a space time tradeoff for distance queries in constant treewidth graphs (Vol.
    57). Presented at the ESA: European Symposium on Algorithms, Aarhus, Denmark:
    Schloss Dagstuhl- Leibniz-Zentrum fur Informatik. <a href="https://doi.org/10.4230/LIPIcs.ESA.2016.28">https://doi.org/10.4230/LIPIcs.ESA.2016.28</a>'
  chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis.
    “Optimal Reachability and a Space Time Tradeoff for Distance Queries in Constant
    Treewidth Graphs,” Vol. 57. Schloss Dagstuhl- Leibniz-Zentrum fur Informatik,
    2016. <a href="https://doi.org/10.4230/LIPIcs.ESA.2016.28">https://doi.org/10.4230/LIPIcs.ESA.2016.28</a>.
  ieee: 'K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, “Optimal reachability
    and a space time tradeoff for distance queries in constant treewidth graphs,”
    presented at the ESA: European Symposium on Algorithms, Aarhus, Denmark, 2016,
    vol. 57.'
  ista: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2016. Optimal reachability
    and a space time tradeoff for distance queries in constant treewidth graphs. ESA:
    European Symposium on Algorithms, LIPIcs, vol. 57, 28.'
  mla: Chatterjee, Krishnendu, et al. <i>Optimal Reachability and a Space Time Tradeoff
    for Distance Queries in Constant Treewidth Graphs</i>. Vol. 57, 28, Schloss Dagstuhl-
    Leibniz-Zentrum fur Informatik, 2016, doi:<a href="https://doi.org/10.4230/LIPIcs.ESA.2016.28">10.4230/LIPIcs.ESA.2016.28</a>.
  short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, in:, Schloss Dagstuhl- Leibniz-Zentrum
    fur Informatik, 2016.
conference:
  end_date: 2016-08-24
  location: Aarhus, Denmark
  name: 'ESA: European Symposium on Algorithms'
  start_date: 2016-08-22
date_created: 2018-12-11T11:49:59Z
date_published: 2016-08-01T00:00:00Z
date_updated: 2023-09-07T12:01:58Z
day: '01'
ddc:
- '004'
- '006'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.ESA.2016.28
ec_funded: 1
file:
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  creator: system
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file_date_updated: 2018-12-12T10:14:31Z
has_accepted_license: '1'
intvolume: '        57'
language:
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month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
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  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication_status: published
publisher: Schloss Dagstuhl- Leibniz-Zentrum fur Informatik
publist_id: '6312'
pubrep_id: '777'
quality_controlled: '1'
related_material:
  record:
  - id: '821'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Optimal reachability and a space time tradeoff for distance queries in constant
  treewidth graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2016'
...
---
_id: '10746'
abstract:
- lang: eng
  text: Vortex states in superconducting (SC) structures, their dynamics and ways
    to manipulate them are topics of great interest. We report a new method of magnetic
    force microscopy (MFM) that allows the study of vortex states in mesoscopic SC
    samples. For the case of a SC ring, which is biased to a half-integer flux quantum,
    the flux modulation through the ring caused by the motion of the magnetic tip
    drives the ring between two consecutive fluxoid states. The corresponding current
    switching in the ring produces strong position-dependent forces on the cantilever.
    In the regime where the frequency of the thermally activated jumps between fluxoid
    states is close to the frequency of the cantilever, large changes in the cantilever
    frequency and dissipation are observed. This effect may be understood as a stochastic
    resonance (SR) process. These changes in the cantilever’s mechanical properties
    are used to “image” the barrier energies between fluxoid states. Additionally,
    SR imaging of the barrier energies are used to study the effect of the locally
    applied magnetic field from the MFM tip on the barrier heights. We report the
    results of measurements for Al rings. Further, the same imaging technique can
    be applied to more sophisticated SC structures such as arrays of Josephson junctions.
alternative_title:
- Bulletin of the American Physical Society
article_number: E25.00007
article_processing_charge: No
author:
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Tyler
  full_name: Naibert, Tyler
  last_name: Naibert
- first_name: Victor
  full_name: Chua, Victor
  last_name: Chua
- first_name: Raffi
  full_name: Budakian, Raffi
  last_name: Budakian
citation:
  ama: 'Polshyn H, Naibert T, Chua V, Budakian R. Study of vortex states and dynamics
    in mesoscopic superconducting samples with MFM. In: <i>APS March Meeting 2016</i>.
    Vol 61. American Physical Society; 2016.'
  apa: 'Polshyn, H., Naibert, T., Chua, V., &#38; Budakian, R. (2016). Study of vortex
    states and dynamics in mesoscopic superconducting samples with MFM. In <i>APS
    March Meeting 2016</i> (Vol. 61). Baltimore, MD, United States: American Physical
    Society.'
  chicago: Polshyn, Hryhoriy, Tyler Naibert, Victor Chua, and Raffi Budakian. “Study
    of Vortex States and Dynamics in Mesoscopic Superconducting Samples with MFM.”
    In <i>APS March Meeting 2016</i>, Vol. 61. American Physical Society, 2016.
  ieee: H. Polshyn, T. Naibert, V. Chua, and R. Budakian, “Study of vortex states
    and dynamics in mesoscopic superconducting samples with MFM,” in <i>APS March
    Meeting 2016</i>, Baltimore, MD, United States, 2016, vol. 61, no. 2.
  ista: 'Polshyn H, Naibert T, Chua V, Budakian R. 2016. Study of vortex states and
    dynamics in mesoscopic superconducting samples with MFM. APS March Meeting 2016.
    APS: American Physical Society, Bulletin of the American Physical Society, vol.
    61, E25.00007.'
  mla: Polshyn, Hryhoriy, et al. “Study of Vortex States and Dynamics in Mesoscopic
    Superconducting Samples with MFM.” <i>APS March Meeting 2016</i>, vol. 61, no.
    2, E25.00007, American Physical Society, 2016.
  short: H. Polshyn, T. Naibert, V. Chua, R. Budakian, in:, APS March Meeting 2016,
    American Physical Society, 2016.
conference:
  end_date: 2016-03-18
  location: Baltimore, MD, United States
  name: 'APS: American Physical Society'
  start_date: 2016-03-14
date_created: 2022-02-08T09:55:09Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2022-02-08T10:44:06Z
day: '01'
extern: '1'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR16/Session/E25.7
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2016
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Study of vortex states and dynamics in mesoscopic superconducting samples with
  MFM
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 61
year: '2016'
...
---
_id: '10747'
abstract:
- lang: eng
  text: Vortex interactions are key to explaining the behavior of many two dimensional
    superconducting systems. We report on the development of a technique to locally
    probe vortex interactions in a 2D array of Josephson junctions. Scanning a magnetic
    tip attached to an ultra-soft cantilever over the array produces changes in the
    frequency of the cantilever along certain lines, forming geometric patterns in
    the scans. Different tip-surface separations and external magnetic fields produce
    a number of different patterns. These patterns correspond to tip locations in
    which two configurations of vortices in the lattice have degenerate energies.
    By imaging the locations of these degeneracies, information on the local vortex
    interactions may be obtained.
alternative_title:
- Bulletin of the American Physical Society
article_number: H25.00006
article_processing_charge: No
author:
- first_name: Tyler
  full_name: Naibert, Tyler
  last_name: Naibert
- first_name: Hryhoriy
  full_name: Polshyn, Hryhoriy
  id: edfc7cb1-526e-11ec-b05a-e6ecc27e4e48
  last_name: Polshyn
  orcid: 0000-0001-8223-8896
- first_name: Brian
  full_name: Wolin, Brian
  last_name: Wolin
- first_name: Malcolm
  full_name: Durkin, Malcolm
  last_name: Durkin
- first_name: Rita
  full_name: Garrido Menacho, Rita
  last_name: Garrido Menacho
- first_name: Ian Mondragon
  full_name: Shem, Ian Mondragon
  last_name: Shem
- first_name: Victor
  full_name: Chua, Victor
  last_name: Chua
- first_name: Taylor
  full_name: Hughes, Taylor
  last_name: Hughes
- first_name: Nadya
  full_name: Mason, Nadya
  last_name: Mason
- first_name: Raffi
  full_name: Budakian, Raffi
  last_name: Budakian
citation:
  ama: 'Naibert T, Polshyn H, Wolin B, et al. Stochastic resonance magnetic force
    microscopy imaging of Josephson arrays. In: <i>APS March Meeting 2016</i>. Vol
    61. American Physical Society; 2016.'
  apa: 'Naibert, T., Polshyn, H., Wolin, B., Durkin, M., Garrido Menacho, R., Shem,
    I. M., … Budakian, R. (2016). Stochastic resonance magnetic force microscopy imaging
    of Josephson arrays. In <i>APS March Meeting 2016</i> (Vol. 61). Baltimore, MD,
    United States: American Physical Society.'
  chicago: Naibert, Tyler, Hryhoriy Polshyn, Brian Wolin, Malcolm Durkin, Rita Garrido
    Menacho, Ian Mondragon Shem, Victor Chua, Taylor Hughes, Nadya Mason, and Raffi
    Budakian. “Stochastic Resonance Magnetic Force Microscopy Imaging of Josephson
    Arrays.” In <i>APS March Meeting 2016</i>, Vol. 61. American Physical Society,
    2016.
  ieee: T. Naibert <i>et al.</i>, “Stochastic resonance magnetic force microscopy
    imaging of Josephson arrays,” in <i>APS March Meeting 2016</i>, Baltimore, MD,
    United States, 2016, vol. 61, no. 2.
  ista: 'Naibert T, Polshyn H, Wolin B, Durkin M, Garrido Menacho R, Shem IM, Chua
    V, Hughes T, Mason N, Budakian R. 2016. Stochastic resonance magnetic force microscopy
    imaging of Josephson arrays. APS March Meeting 2016. APS: American Physical Society,
    Bulletin of the American Physical Society, vol. 61, H25.00006.'
  mla: Naibert, Tyler, et al. “Stochastic Resonance Magnetic Force Microscopy Imaging
    of Josephson Arrays.” <i>APS March Meeting 2016</i>, vol. 61, no. 2, H25.00006,
    American Physical Society, 2016.
  short: T. Naibert, H. Polshyn, B. Wolin, M. Durkin, R. Garrido Menacho, I.M. Shem,
    V. Chua, T. Hughes, N. Mason, R. Budakian, in:, APS March Meeting 2016, American
    Physical Society, 2016.
conference:
  end_date: 2016-03-18
  location: Baltimore, MD, United States
  name: 'APS: American Physical Society'
  start_date: 2016-03-14
date_created: 2022-02-08T10:10:39Z
date_published: 2016-03-01T00:00:00Z
date_updated: 2022-02-08T10:43:33Z
day: '01'
extern: '1'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://meetings.aps.org/Meeting/MAR16/Session/H25.6
month: '03'
oa: 1
oa_version: Published Version
publication: APS March Meeting 2016
publication_identifier:
  issn:
  - 0003-0503
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Stochastic resonance magnetic force microscopy imaging of Josephson arrays
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 61
year: '2016'
...
