---
_id: '9019'
abstract:
- lang: eng
text: Targeting protein–protein interactions has long been considered as a very
difficult if impossible task, but over the past decade, front lines have moved.
The number of successful examples is exponentially growing. This review presents
a rapid overview of recent advances in this field considering the strengths and
weaknesses of the small molecule approaches and alternative strategies such as
the selection or design of artificial antibodies, peptides or peptidomimetics.
- lang: fre
text: Cibler les interactions protéine–protéine a longtemps été considéré comme
une tâche très difficile, voire impossible, mais, depuis les dix dernières années,
les lignes ont bougé. Le nombre d’exemples de réussites s’accroît exponentiellement.
Cette revue présente un rapide panorama des avancées récentes dans ce domaine,
considérant les forces et les faiblesses de l’approche « petite molécule » ainsi
que des stratégies alternatives comme la sélection ou le design d’anticorps artificiels,
de peptides ou de peptidomimétiques.
article_processing_charge: No
article_type: original
author:
- first_name: May M
full_name: Bakail, May M
id: FB3C3F8E-522F-11EA-B186-22963DDC885E
last_name: Bakail
orcid: 0000-0002-9592-1587
- first_name: Francoise
full_name: Ochsenbein, Francoise
last_name: Ochsenbein
citation:
ama: Bakail MM, Ochsenbein F. Targeting protein–protein interactions, a wide open
field for drug design. Comptes Rendus Chimie. 2016;19(1-2):19-27. doi:10.1016/j.crci.2015.12.004
apa: Bakail, M. M., & Ochsenbein, F. (2016). Targeting protein–protein interactions,
a wide open field for drug design. Comptes Rendus Chimie. Elsevier. https://doi.org/10.1016/j.crci.2015.12.004
chicago: Bakail, May M, and Francoise Ochsenbein. “Targeting Protein–Protein Interactions,
a Wide Open Field for Drug Design.” Comptes Rendus Chimie. Elsevier, 2016.
https://doi.org/10.1016/j.crci.2015.12.004.
ieee: M. M. Bakail and F. Ochsenbein, “Targeting protein–protein interactions, a
wide open field for drug design,” Comptes Rendus Chimie, vol. 19, no. 1–2.
Elsevier, pp. 19–27, 2016.
ista: Bakail MM, Ochsenbein F. 2016. Targeting protein–protein interactions, a wide
open field for drug design. Comptes Rendus Chimie. 19(1–2), 19–27.
mla: Bakail, May M., and Francoise Ochsenbein. “Targeting Protein–Protein Interactions,
a Wide Open Field for Drug Design.” Comptes Rendus Chimie, vol. 19, no.
1–2, Elsevier, 2016, pp. 19–27, doi:10.1016/j.crci.2015.12.004.
short: M.M. Bakail, F. Ochsenbein, Comptes Rendus Chimie 19 (2016) 19–27.
date_created: 2021-01-19T11:11:54Z
date_published: 2016-02-06T00:00:00Z
date_updated: 2023-02-23T13:46:55Z
day: '06'
ddc:
- '570'
doi: 10.1016/j.crci.2015.12.004
extern: '1'
file:
- access_level: open_access
checksum: c262814ffdbfe95900256ab9ff42cdf5
content_type: application/pdf
creator: dernst
date_created: 2021-01-22T12:36:52Z
date_updated: 2021-01-22T12:36:52Z
file_id: '9035'
file_name: 2016_ComptesRendueChimie_Bakail.pdf
file_size: 2045260
relation: main_file
success: 1
file_date_updated: 2021-01-22T12:36:52Z
has_accepted_license: '1'
intvolume: ' 19'
issue: 1-2
keyword:
- General Chemistry
- General Chemical Engineering
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 19-27
publication: Comptes Rendus Chimie
publication_identifier:
issn:
- 1631-0748
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Targeting protein–protein interactions, a wide open field for drug design
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2016'
...
---
_id: '9051'
abstract:
- lang: eng
text: 'Biological systems often involve the self-assembly of basic components into
complex and functioning structures. Artificial systems that mimic such processes
can provide a well-controlled setting to explore the principles involved and also
synthesize useful micromachines. Our experiments show that immotile, but active,
components self-assemble into two types of structure that exhibit the fundamental
forms of motility: translation and rotation. Specifically, micron-scale metallic
rods are designed to induce extensile surface flows in the presence of a chemical
fuel; these rods interact with each other and pair up to form either a swimmer
or a rotor. Such pairs can transition reversibly between these two configurations,
leading to kinetics reminiscent of bacterial run-and-tumble motion.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Megan S.
full_name: Davies Wykes, Megan S.
last_name: Davies Wykes
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
- first_name: Takuji
full_name: Adachi, Takuji
last_name: Adachi
- first_name: Leif
full_name: Ristroph, Leif
last_name: Ristroph
- first_name: Xiao
full_name: Zhong, Xiao
last_name: Zhong
- first_name: Michael D.
full_name: Ward, Michael D.
last_name: Ward
- first_name: Jun
full_name: Zhang, Jun
last_name: Zhang
- first_name: Michael J.
full_name: Shelley, Michael J.
last_name: Shelley
citation:
ama: Davies Wykes MS, Palacci JA, Adachi T, et al. Dynamic self-assembly of microscale
rotors and swimmers. Soft Matter. 2016;12(20):4584-4589. doi:10.1039/c5sm03127c
apa: Davies Wykes, M. S., Palacci, J. A., Adachi, T., Ristroph, L., Zhong, X., Ward,
M. D., … Shelley, M. J. (2016). Dynamic self-assembly of microscale rotors and
swimmers. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/c5sm03127c
chicago: Davies Wykes, Megan S., Jérémie A Palacci, Takuji Adachi, Leif Ristroph,
Xiao Zhong, Michael D. Ward, Jun Zhang, and Michael J. Shelley. “Dynamic Self-Assembly
of Microscale Rotors and Swimmers.” Soft Matter. Royal Society of Chemistry,
2016. https://doi.org/10.1039/c5sm03127c.
ieee: M. S. Davies Wykes et al., “Dynamic self-assembly of microscale rotors
and swimmers,” Soft Matter, vol. 12, no. 20. Royal Society of Chemistry,
pp. 4584–4589, 2016.
ista: Davies Wykes MS, Palacci JA, Adachi T, Ristroph L, Zhong X, Ward MD, Zhang
J, Shelley MJ. 2016. Dynamic self-assembly of microscale rotors and swimmers.
Soft Matter. 12(20), 4584–4589.
mla: Davies Wykes, Megan S., et al. “Dynamic Self-Assembly of Microscale Rotors
and Swimmers.” Soft Matter, vol. 12, no. 20, Royal Society of Chemistry,
2016, pp. 4584–89, doi:10.1039/c5sm03127c.
short: M.S. Davies Wykes, J.A. Palacci, T. Adachi, L. Ristroph, X. Zhong, M.D. Ward,
J. Zhang, M.J. Shelley, Soft Matter 12 (2016) 4584–4589.
date_created: 2021-02-01T13:44:00Z
date_published: 2016-05-28T00:00:00Z
date_updated: 2023-02-23T13:47:38Z
day: '28'
doi: 10.1039/c5sm03127c
extern: '1'
external_id:
arxiv:
- '1509.06330'
pmid:
- '27121100'
intvolume: ' 12'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1509.06330
month: '05'
oa: 1
oa_version: Preprint
page: 4584-4589
pmid: 1
publication: Soft Matter
publication_identifier:
eissn:
- 1744-6848
issn:
- 1744-683X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic self-assembly of microscale rotors and swimmers
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 12
year: '2016'
...
---
_id: '9052'
abstract:
- lang: eng
text: We describe colloidal Janus particles with metallic and dielectric faces that
swim vigorously when illuminated by defocused optical tweezers without consuming
any chemical fuel. Rather than wandering randomly, these optically-activated colloidal
swimmers circulate back and forth through the beam of light, tracing out sinuous
rosette patterns. We propose a model for this mode of light-activated transport
that accounts for the observed behavior through a combination of self-thermophoresis
and optically-induced torque. In the deterministic limit, this model yields trajectories
that resemble rosette curves known as hypotrochoids.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Henrique
full_name: Moyses, Henrique
last_name: Moyses
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
- first_name: Stefano
full_name: Sacanna, Stefano
last_name: Sacanna
- first_name: David G.
full_name: Grier, David G.
last_name: Grier
citation:
ama: Moyses H, Palacci JA, Sacanna S, Grier DG. Trochoidal trajectories of self-propelled
Janus particles in a diverging laser beam. Soft Matter. 2016;12(30):6357-6364.
doi:10.1039/c6sm01163b
apa: Moyses, H., Palacci, J. A., Sacanna, S., & Grier, D. G. (2016). Trochoidal
trajectories of self-propelled Janus particles in a diverging laser beam. Soft
Matter. Royal Society of Chemistry . https://doi.org/10.1039/c6sm01163b
chicago: Moyses, Henrique, Jérémie A Palacci, Stefano Sacanna, and David G. Grier.
“Trochoidal Trajectories of Self-Propelled Janus Particles in a Diverging Laser
Beam.” Soft Matter. Royal Society of Chemistry , 2016. https://doi.org/10.1039/c6sm01163b.
ieee: H. Moyses, J. A. Palacci, S. Sacanna, and D. G. Grier, “Trochoidal trajectories
of self-propelled Janus particles in a diverging laser beam,” Soft Matter,
vol. 12, no. 30. Royal Society of Chemistry , pp. 6357–6364, 2016.
ista: Moyses H, Palacci JA, Sacanna S, Grier DG. 2016. Trochoidal trajectories of
self-propelled Janus particles in a diverging laser beam. Soft Matter. 12(30),
6357–6364.
mla: Moyses, Henrique, et al. “Trochoidal Trajectories of Self-Propelled Janus Particles
in a Diverging Laser Beam.” Soft Matter, vol. 12, no. 30, Royal Society
of Chemistry , 2016, pp. 6357–64, doi:10.1039/c6sm01163b.
short: H. Moyses, J.A. Palacci, S. Sacanna, D.G. Grier, Soft Matter 12 (2016) 6357–6364.
date_created: 2021-02-01T13:44:15Z
date_published: 2016-08-14T00:00:00Z
date_updated: 2023-02-23T13:47:40Z
day: '14'
doi: 10.1039/c6sm01163b
extern: '1'
external_id:
arxiv:
- '1609.01497'
pmid:
- '27338294'
intvolume: ' 12'
issue: '30'
keyword:
- General Chemistry
- Condensed Matter Physics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1609.01497
month: '08'
oa: 1
oa_version: Preprint
page: 6357-6364
pmid: 1
publication: Soft Matter
publication_identifier:
eissn:
- 1744-6848
issn:
- 1744-683X
publication_status: published
publisher: 'Royal Society of Chemistry '
quality_controlled: '1'
scopus_import: '1'
status: public
title: Trochoidal trajectories of self-propelled Janus particles in a diverging laser
beam
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 12
year: '2016'
...
---
_id: '9140'
abstract:
- lang: eng
text: 'Expected changes to future extreme precipitation remain a key uncertainty
associated with anthropogenic climate change. Extreme precipitation has been proposed
to scale with the precipitable water content in the atmosphere. Assuming constant
relative humidity, this implies an increase of precipitation extremes at a rate
of about 7% °C−1 globally as indicated by the Clausius‐Clapeyron relationship.
Increases faster and slower than Clausius‐Clapeyron have also been reported. In
this work, we examine the scaling between precipitation extremes and temperature
in the present climate using simulations and measurements from surface weather
stations collected in the frame of the HyMeX and MED‐CORDEX programs in Southern
France. Of particular interest are departures from the Clausius‐Clapeyron thermodynamic
expectation, their spatial and temporal distribution, and their origin. Looking
at the scaling of precipitation extreme with temperature, two regimes emerge which
form a hook shape: one at low temperatures (cooler than around 15°C) with rates
of increase close to the Clausius‐Clapeyron rate and one at high temperatures
(warmer than about 15°C) with sub‐Clausius‐Clapeyron rates and most often negative
rates. On average, the region of focus does not seem to exhibit super Clausius‐Clapeyron
behavior except at some stations, in contrast to earlier studies. Many factors
can contribute to departure from Clausius‐Clapeyron scaling: time and spatial
averaging, choice of scaling temperature (surface versus condensation level),
and precipitation efficiency and vertical velocity in updrafts that are not necessarily
constant with temperature. But most importantly, the dynamical contribution of
orography to precipitation in the fall over this area during the so‐called “Cevenoles”
events, explains the hook shape of the scaling of precipitation extremes.'
article_processing_charge: No
article_type: original
author:
- first_name: P.
full_name: Drobinski, P.
last_name: Drobinski
- first_name: B.
full_name: Alonzo, B.
last_name: Alonzo
- first_name: S.
full_name: Bastin, S.
last_name: Bastin
- first_name: N. Da
full_name: Silva, N. Da
last_name: Silva
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
citation:
ama: 'Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. Scaling of precipitation
extremes with temperature in the French Mediterranean region: What explains the
hook shape? Journal of Geophysical Research: Atmospheres. 2016;121(7):3100-3119.
doi:10.1002/2015jd023497'
apa: 'Drobinski, P., Alonzo, B., Bastin, S., Silva, N. D., & Muller, C. J. (2016).
Scaling of precipitation extremes with temperature in the French Mediterranean
region: What explains the hook shape? Journal of Geophysical Research: Atmospheres.
American Geophysical Union. https://doi.org/10.1002/2015jd023497'
chicago: 'Drobinski, P., B. Alonzo, S. Bastin, N. Da Silva, and Caroline J Muller.
“Scaling of Precipitation Extremes with Temperature in the French Mediterranean
Region: What Explains the Hook Shape?” Journal of Geophysical Research: Atmospheres.
American Geophysical Union, 2016. https://doi.org/10.1002/2015jd023497.'
ieee: 'P. Drobinski, B. Alonzo, S. Bastin, N. D. Silva, and C. J. Muller, “Scaling
of precipitation extremes with temperature in the French Mediterranean region:
What explains the hook shape?,” Journal of Geophysical Research: Atmospheres,
vol. 121, no. 7. American Geophysical Union, pp. 3100–3119, 2016.'
ista: 'Drobinski P, Alonzo B, Bastin S, Silva ND, Muller CJ. 2016. Scaling of precipitation
extremes with temperature in the French Mediterranean region: What explains the
hook shape? Journal of Geophysical Research: Atmospheres. 121(7), 3100–3119.'
mla: 'Drobinski, P., et al. “Scaling of Precipitation Extremes with Temperature
in the French Mediterranean Region: What Explains the Hook Shape?” Journal
of Geophysical Research: Atmospheres, vol. 121, no. 7, American Geophysical
Union, 2016, pp. 3100–19, doi:10.1002/2015jd023497.'
short: 'P. Drobinski, B. Alonzo, S. Bastin, N.D. Silva, C.J. Muller, Journal of
Geophysical Research: Atmospheres 121 (2016) 3100–3119.'
date_created: 2021-02-15T14:21:16Z
date_published: 2016-03-16T00:00:00Z
date_updated: 2022-01-24T13:41:02Z
day: '16'
doi: 10.1002/2015jd023497
extern: '1'
intvolume: ' 121'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/2015JD023497
month: '03'
oa: 1
oa_version: Published Version
page: 3100-3119
publication: 'Journal of Geophysical Research: Atmospheres'
publication_identifier:
issn:
- 2169-897X
- 2169-8996
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
status: public
title: 'Scaling of precipitation extremes with temperature in the French Mediterranean
region: What explains the hook shape?'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 121
year: '2016'
...
---
_id: '92'
abstract:
- lang: eng
text: 'Advanced organic nonlinear optical (NLO) materials have attracted increasing
attention due to their multitude of applications in modern telecommunication devices.
Arguably the most important advantage of organic NLO materials, relative to traditionally
used inorganic NLO materials, is their short optical response time. Geminal amido
esters with their donor-π-acceptor (D-π-A) architecture exhibit high levels of
electron delocalization and substantial intramolecular charge transfer, which
should endow these materials with short optical response times and large molecular
(hyper)polarizabilities. In order to test this hypothesis, the linear and second-order
nonlinear optical properties of five geminal amido esters, (E)-ethyl 3-(X-phenylamino)-2-(Y-phenylcarbamoyl)acrylate
(1, X = 4-H, Y = 4-H; 2, X = 4-CH3, Y = 4-CH3; 3, X = 4-NO2, Y = 2,5-OCH3; 4,
X = 2-Cl, Y = 2-Cl; 5, X = 4-Cl, Y = 4-Cl) were synthesized and characterized,
whereby NLO structure-function relationships were established including intramolecular
charge transfer characteristics, crystal field effects, and molecular first hyperpolarizabilities
(β). Given the typically large errors (10-30%) associated with the determination
of β coefficients, three independent methods were used: (i) density functional
theory, (ii) hyper-Rayleigh scattering, and (iii) high-resolution X-ray diffraction
data analysis based on multipolar modeling of electron densities at each atom.
These three methods delivered consistent values of β, and based on these results,
3 should hold the most promise for NLO applications. The correlation between the
molecular structure of these geminal amido esters and their linear and nonlinear
optical properties thus provide molecular design guidelines for organic NLO materials;
this leads to the ultimate goal of generating bespoke organic molecules to suit
a given NLO device application.'
acknowledgement: J.M.C. thanks the 1851 Royal Commission of the Great Exhibition for
a Design Fellowship, hosted by Argonne National Laboratory where work done was supported
by the DOE Office of Science, Office of Basic Energy Sciences, under Contract No.
DE-AC02-06CH11357. T.-C.L acknowledges the Taiwanese Government for a Studying Abroad
Scholarship. C.M.A is indebted to the EPSRC UK for a DTA Ph.D. studentship (Grants
EP/J500380/1 and EP/L504920/1). Y.T. is grateful for a Cavendish-NUDT Scholarship.
The Swiss-Norwegian Collaborative Research Group at the ESRF, Grenoble, France,
is thanked for access to synchrotron facilities. The OPAL reactor, ANSTO, Australia,
is acknowledged for access to neutron scattering facilities via a program proposal,
ID 1236. J.P-M. is grateful to Skidmore College for supporting this work via a full-year
sabbatical with enhancement. All authors thank the EPSRC UK National Service for
Computational Chemistry Software (NSCCS) and acknowledge contributions from its
staff in supporting this work.
author:
- first_name: Jaqueline
full_name: Cole, Jaqueline
last_name: Cole
- first_name: Tzechia
full_name: Lin, Tzechia
last_name: Lin
- first_name: Christopher
full_name: Ashcroft, Christopher
last_name: Ashcroft
- first_name: Javier
full_name: Pérez Moreno, Javier
last_name: Pérez Moreno
- first_name: Yizhou
full_name: Tan, Yizhou
last_name: Tan
- first_name: Perumal
full_name: Venkatesan, Perumal
last_name: Venkatesan
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
- first_name: Philip
full_name: Pattison, Philip
last_name: Pattison
- first_name: Alison
full_name: Edwards, Alison
last_name: Edwards
- first_name: Ross
full_name: Piltz, Ross
last_name: Piltz
- first_name: Koen
full_name: Clays, Koen
last_name: Clays
- first_name: Andivelu
full_name: Ilangovan, Andivelu
last_name: Ilangovan
citation:
ama: Cole J, Lin T, Ashcroft C, et al. Relating the structure of geminal Amido Esters
to their molecular hyperpolarizability. Journal of Physical Chemistry C.
2016;120(51):29439-29448. doi:10.1021/acs.jpcc.6b10724
apa: Cole, J., Lin, T., Ashcroft, C., Pérez Moreno, J., Tan, Y., Venkatesan, P.,
… Ilangovan, A. (2016). Relating the structure of geminal Amido Esters to their
molecular hyperpolarizability. Journal of Physical Chemistry C. American
Chemical Society. https://doi.org/10.1021/acs.jpcc.6b10724
chicago: Cole, Jaqueline, Tzechia Lin, Christopher Ashcroft, Javier Pérez Moreno,
Yizhou Tan, Perumal Venkatesan, Andrew P Higginbotham, et al. “Relating the Structure
of Geminal Amido Esters to Their Molecular Hyperpolarizability.” Journal of
Physical Chemistry C. American Chemical Society, 2016. https://doi.org/10.1021/acs.jpcc.6b10724.
ieee: J. Cole et al., “Relating the structure of geminal Amido Esters to
their molecular hyperpolarizability,” Journal of Physical Chemistry C,
vol. 120, no. 51. American Chemical Society, pp. 29439–29448, 2016.
ista: Cole J, Lin T, Ashcroft C, Pérez Moreno J, Tan Y, Venkatesan P, Higginbotham
AP, Pattison P, Edwards A, Piltz R, Clays K, Ilangovan A. 2016. Relating the structure
of geminal Amido Esters to their molecular hyperpolarizability. Journal of Physical
Chemistry C. 120(51), 29439–29448.
mla: Cole, Jaqueline, et al. “Relating the Structure of Geminal Amido Esters to
Their Molecular Hyperpolarizability.” Journal of Physical Chemistry C,
vol. 120, no. 51, American Chemical Society, 2016, pp. 29439–48, doi:10.1021/acs.jpcc.6b10724.
short: J. Cole, T. Lin, C. Ashcroft, J. Pérez Moreno, Y. Tan, P. Venkatesan, A.P.
Higginbotham, P. Pattison, A. Edwards, R. Piltz, K. Clays, A. Ilangovan, Journal
of Physical Chemistry C 120 (2016) 29439–29448.
date_created: 2018-12-11T11:44:35Z
date_published: 2016-12-05T00:00:00Z
date_updated: 2021-01-12T08:21:55Z
day: '05'
doi: 10.1021/acs.jpcc.6b10724
extern: '1'
intvolume: ' 120'
issue: '51'
language:
- iso: eng
month: '12'
oa_version: None
page: 29439 - 29448
publication: Journal of Physical Chemistry C
publication_status: published
publisher: American Chemical Society
publist_id: '7962'
quality_controlled: '1'
status: public
title: Relating the structure of geminal Amido Esters to their molecular hyperpolarizability
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 120
year: '2016'
...
---
_id: '930'
abstract:
- lang: eng
text: The changes in cell dynamics after oncogenic mutation that lead to the development
of tumours are currently unknown. Here, using skin epidermis as a model, we assessed
the effect of oncogenic hedgehog signalling in distinct cell populations and their
capacity to induce basal cell carcinoma, the most frequent cancer in humans. We
found that only stem cells, and not progenitors, initiated tumour formation upon
oncogenic hedgehog signalling. This difference was due to the hierarchical organization
of tumour growth in oncogene-targeted stem cells, characterized by an increase
in symmetric self-renewing divisions and a higher p53-dependent resistance to
apoptosis, leading to rapid clonal expansion and progression into invasive tumours.
Our work reveals that the capacity of oncogene-targeted cells to induce tumour
formation is dependent not only on their long-term survival and expansion, but
also on the specific clonal dynamics of the cancer cell of origin.
acknowledgement: We would like to thank J.-M. Vanderwinden and the LiMiF for the help
with confocal microscopy. C.B. is an investigator of WELBIO. A.S.-D. and J.C.L.
are supported by a fellowship of the FNRS and FRIA respectively. B.D.S. and E.H.
are supported by the Wellcome Trust (grant numbers 098357/Z/12/Z and 110326/Z/15/Z).
E.H. is supported by a fellowship from Trinity College, Cambridge. This work was
supported by the FNRS, the IUAP program, the Fondation contre le Cancer, the ULB
fondation, the foundation Bettencourt Schueller, the foundation Baillet Latour,
a consolidator grant of the European Research Council.
article_processing_charge: No
author:
- first_name: Adriana
full_name: Sánchez Danés, Adriana
last_name: Sánchez Danés
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Jean
full_name: Larsimont, Jean
last_name: Larsimont
- first_name: Mélanie
full_name: Liagre, Mélanie
last_name: Liagre
- first_name: Khalil
full_name: Youssef, Khalil
last_name: Youssef
- first_name: Benjamin
full_name: Simons, Benjamin
last_name: Simons
- first_name: Cédric
full_name: Blanpain, Cédric
last_name: Blanpain
citation:
ama: Sánchez Danés A, Hannezo EB, Larsimont J, et al. Defining the clonal dynamics
leading to mouse skin tumour initiation. Nature. 2016;536(7616):298-303.
doi:10.1038/nature19069
apa: Sánchez Danés, A., Hannezo, E. B., Larsimont, J., Liagre, M., Youssef, K.,
Simons, B., & Blanpain, C. (2016). Defining the clonal dynamics leading to
mouse skin tumour initiation. Nature. Nature Publishing Group. https://doi.org/10.1038/nature19069
chicago: Sánchez Danés, Adriana, Edouard B Hannezo, Jean Larsimont, Mélanie Liagre,
Khalil Youssef, Benjamin Simons, and Cédric Blanpain. “Defining the Clonal Dynamics
Leading to Mouse Skin Tumour Initiation.” Nature. Nature Publishing Group,
2016. https://doi.org/10.1038/nature19069.
ieee: A. Sánchez Danés et al., “Defining the clonal dynamics leading to mouse
skin tumour initiation,” Nature, vol. 536, no. 7616. Nature Publishing
Group, pp. 298–303, 2016.
ista: Sánchez Danés A, Hannezo EB, Larsimont J, Liagre M, Youssef K, Simons B, Blanpain
C. 2016. Defining the clonal dynamics leading to mouse skin tumour initiation.
Nature. 536(7616), 298–303.
mla: Sánchez Danés, Adriana, et al. “Defining the Clonal Dynamics Leading to Mouse
Skin Tumour Initiation.” Nature, vol. 536, no. 7616, Nature Publishing
Group, 2016, pp. 298–303, doi:10.1038/nature19069.
short: A. Sánchez Danés, E.B. Hannezo, J. Larsimont, M. Liagre, K. Youssef, B. Simons,
C. Blanpain, Nature 536 (2016) 298–303.
date_created: 2018-12-11T11:49:15Z
date_published: 2016-07-08T00:00:00Z
date_updated: 2021-01-12T08:21:59Z
day: '08'
doi: 10.1038/nature19069
extern: '1'
intvolume: ' 536'
issue: '7616'
language:
- iso: eng
month: '07'
oa_version: None
page: 298 - 303
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '6508'
status: public
title: Defining the clonal dynamics leading to mouse skin tumour initiation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 536
year: '2016'
...
---
_id: '931'
abstract:
- lang: eng
text: 'In many adult tissues, stem cells and differentiated cells are not homogeneously
distributed: stem cells are arranged in periodic "niches," and differentiated
cells are constantly produced and migrate out of these niches. In this article,
we provide a general theoretical framework to study mixtures of dividing and actively
migrating particles, which we apply to biological tissues. We show in particular
that the interplay between the stresses arising from active cell migration and
stem cell division give rise to robust stem cell patterns. The instability of
the tissue leads to spatial patterns which are either steady or oscillating in
time. The wavelength of the instability has an order of magnitude consistent with
the biological observations. We also discuss the implications of these results
for future in vitro and in vivo experiments.'
acknowledgement: The authors thank Jacques Prost and Pierre Recho for helpful discussions,
as well as the Labex CelTisPhyBio and all its members. E.H. acknowledges for funding
a Young Researcher Prize from the Bettencourt-Schueller Fondation, and a Junior
Research Fellowship from Trinity College, Cambridge.
article_processing_charge: No
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Alice
full_name: Coucke, Alice
last_name: Coucke
- first_name: Jean
full_name: Joanny, Jean
last_name: Joanny
citation:
ama: Hannezo EB, Coucke A, Joanny J. Interplay of migratory and division forces
as a generic mechanism for stem cell patterns. Physical Review E Statistical
Nonlinear and Soft Matter Physics. 2016;93(2). doi:10.1103/PhysRevE.93.022405
apa: Hannezo, E. B., Coucke, A., & Joanny, J. (2016). Interplay of migratory
and division forces as a generic mechanism for stem cell patterns. Physical
Review E Statistical Nonlinear and Soft Matter Physics. American Institute
of Physics. https://doi.org/10.1103/PhysRevE.93.022405
chicago: Hannezo, Edouard B, Alice Coucke, and Jean Joanny. “Interplay of Migratory
and Division Forces as a Generic Mechanism for Stem Cell Patterns.” Physical
Review E Statistical Nonlinear and Soft Matter Physics. American Institute
of Physics, 2016. https://doi.org/10.1103/PhysRevE.93.022405.
ieee: E. B. Hannezo, A. Coucke, and J. Joanny, “Interplay of migratory and division
forces as a generic mechanism for stem cell patterns,” Physical Review E Statistical
Nonlinear and Soft Matter Physics, vol. 93, no. 2. American Institute of Physics,
2016.
ista: Hannezo EB, Coucke A, Joanny J. 2016. Interplay of migratory and division
forces as a generic mechanism for stem cell patterns. Physical Review E Statistical
Nonlinear and Soft Matter Physics. 93(2).
mla: Hannezo, Edouard B., et al. “Interplay of Migratory and Division Forces as
a Generic Mechanism for Stem Cell Patterns.” Physical Review E Statistical
Nonlinear and Soft Matter Physics, vol. 93, no. 2, American Institute of Physics,
2016, doi:10.1103/PhysRevE.93.022405.
short: E.B. Hannezo, A. Coucke, J. Joanny, Physical Review E Statistical Nonlinear
and Soft Matter Physics 93 (2016).
date_created: 2018-12-11T11:49:16Z
date_published: 2016-02-28T00:00:00Z
date_updated: 2021-01-12T08:22:00Z
day: '28'
doi: 10.1103/PhysRevE.93.022405
extern: '1'
intvolume: ' 93'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
publication: Physical Review E Statistical Nonlinear and Soft Matter Physics
publication_status: published
publisher: American Institute of Physics
publist_id: '6509'
status: public
title: Interplay of migratory and division forces as a generic mechanism for stem
cell patterns
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 93
year: '2016'
...
---
_id: '932'
abstract:
- lang: eng
text: Epithelial sheets are crucial components of all metazoan animals, enclosing
organs and protecting the animal from its environment. Epithelial homeostasis
poses unique challenges, as addition of new cells and loss of old cells must be
achieved without disrupting the fluid-tight barrier and apicobasal polarity of
the epithelium. Several studies have identified cell biological mechanisms underlying
extrusion of cells from epithelia, but far less is known of the converse mechanism
by which new cells are added. Here, we combine molecular, pharmacological, and
laser-dissection experiments with theoretical modeling to characterize forces
driving emergence of an apical surface as single nascent cells are added to a
vertebrate epithelium in vivo. We find that this process involves the interplay
between cell-autonomous actin-generated pushing forces in the emerging cell and
mechanical properties of neighboring cells. Our findings define the forces driving
this cell behavior, contributing to a more comprehensive understanding of epithelial
homeostasis.
acknowledgement: We thank J. Bear, B. Goldstein, A. Ewald, and D. Soroldoni for critical
reading. This work was funded by an EMBO Long Term Fellowship to J.S., a Research
Fellowship from Trinity College, Cambridge and a Bettencourt-Schueller Foundation
Young Researcher Prize to E.H., a Cancer Institute NSW Early Career Researcher fellowship
(13/ECF/1–25) and a Cancer Australia/Cure Cancer Australia Foundation project grant
(1070498) to M.B., and grants from the NHLBI (HL117164) and NIGMS (GM074104) to
J.B.W. J.B.W. was an early career scientist of the Howard Hughes Medical Institute.
This work was initiated at the New Quantitative Approaches to Morphogenesis Workshop
at UCSB, which is funded in part by the National Science Foundation (PHY11-25915)
and the NIGMS (GM067110-05).
article_processing_charge: No
author:
- first_name: Jakub
full_name: Sedzinski, Jakub
last_name: Sedzinski
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Fan
full_name: Tu, Fan
last_name: Tu
- first_name: Maté
full_name: Biro, Maté
last_name: Biro
- first_name: John
full_name: Wallingford, John
last_name: Wallingford
citation:
ama: Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. Emergence of an Apical
Epithelial Cell Surface In Vivo. Developmental Cell. 2016;36(1):24-35.
doi:10.1016/j.devcel.2015.12.013
apa: Sedzinski, J., Hannezo, E. B., Tu, F., Biro, M., & Wallingford, J. (2016).
Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell.
Cell Press. https://doi.org/10.1016/j.devcel.2015.12.013
chicago: Sedzinski, Jakub, Edouard B Hannezo, Fan Tu, Maté Biro, and John Wallingford.
“Emergence of an Apical Epithelial Cell Surface In Vivo.” Developmental Cell.
Cell Press, 2016. https://doi.org/10.1016/j.devcel.2015.12.013.
ieee: J. Sedzinski, E. B. Hannezo, F. Tu, M. Biro, and J. Wallingford, “Emergence
of an Apical Epithelial Cell Surface In Vivo,” Developmental Cell, vol.
36, no. 1. Cell Press, pp. 24–35, 2016.
ista: Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. 2016. Emergence of an
Apical Epithelial Cell Surface In Vivo. Developmental Cell. 36(1), 24–35.
mla: Sedzinski, Jakub, et al. “Emergence of an Apical Epithelial Cell Surface In
Vivo.” Developmental Cell, vol. 36, no. 1, Cell Press, 2016, pp. 24–35,
doi:10.1016/j.devcel.2015.12.013.
short: J. Sedzinski, E.B. Hannezo, F. Tu, M. Biro, J. Wallingford, Developmental
Cell 36 (2016) 24–35.
date_created: 2018-12-11T11:49:16Z
date_published: 2016-01-12T00:00:00Z
date_updated: 2021-01-12T08:22:00Z
day: '12'
doi: 10.1016/j.devcel.2015.12.013
extern: '1'
intvolume: ' 36'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 24 - 35
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '6510'
status: public
title: Emergence of an Apical Epithelial Cell Surface In Vivo
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2016'
...
---
_id: '7068'
abstract:
- lang: eng
text: Electrons in materials with linear dispersion behave as massless Weyl- or
Dirac-quasiparticles, and continue to intrigue due to their close resemblance
to elusive ultra-relativistic particles as well as their potential for future
electronics. Yet the experimental signatures of Weyl-fermions are often subtle
and indirect, in particular if they coexist with conventional, massive quasiparticles.
Here we show a pronounced anomaly in the magnetic torque of the Weyl semimetal
NbAs upon entering the quantum limit state in high magnetic fields. The torque
changes sign in the quantum limit, signalling a reversal of the magnetic anisotropy
that can be directly attributed to the topological nature of the Weyl electrons.
Our results establish that anomalous quantum limit torque measurements provide
a direct experimental method to identify and distinguish Weyl and Dirac systems.
article_number: '12492'
article_processing_charge: No
article_type: original
author:
- first_name: Philip J. W.
full_name: Moll, Philip J. W.
last_name: Moll
- first_name: Andrew C.
full_name: Potter, Andrew C.
last_name: Potter
- first_name: Nityan L.
full_name: Nair, Nityan L.
last_name: Nair
- first_name: B. J.
full_name: Ramshaw, B. J.
last_name: Ramshaw
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Scott
full_name: Riggs, Scott
last_name: Riggs
- first_name: Bin
full_name: Zeng, Bin
last_name: Zeng
- first_name: Nirmal J.
full_name: Ghimire, Nirmal J.
last_name: Ghimire
- first_name: Eric D.
full_name: Bauer, Eric D.
last_name: Bauer
- first_name: Robert
full_name: Kealhofer, Robert
last_name: Kealhofer
- first_name: Filip
full_name: Ronning, Filip
last_name: Ronning
- first_name: James G.
full_name: Analytis, James G.
last_name: Analytis
citation:
ama: Moll PJW, Potter AC, Nair NL, et al. Magnetic torque anomaly in the quantum
limit of Weyl semimetals. Nature Communications. 2016;7. doi:10.1038/ncomms12492
apa: Moll, P. J. W., Potter, A. C., Nair, N. L., Ramshaw, B. J., Modic, K. A., Riggs,
S., … Analytis, J. G. (2016). Magnetic torque anomaly in the quantum limit of
Weyl semimetals. Nature Communications. Springer Nature. https://doi.org/10.1038/ncomms12492
chicago: Moll, Philip J. W., Andrew C. Potter, Nityan L. Nair, B. J. Ramshaw, Kimberly
A Modic, Scott Riggs, Bin Zeng, et al. “Magnetic Torque Anomaly in the Quantum
Limit of Weyl Semimetals.” Nature Communications. Springer Nature, 2016.
https://doi.org/10.1038/ncomms12492.
ieee: P. J. W. Moll et al., “Magnetic torque anomaly in the quantum limit
of Weyl semimetals,” Nature Communications, vol. 7. Springer Nature, 2016.
ista: Moll PJW, Potter AC, Nair NL, Ramshaw BJ, Modic KA, Riggs S, Zeng B, Ghimire
NJ, Bauer ED, Kealhofer R, Ronning F, Analytis JG. 2016. Magnetic torque anomaly
in the quantum limit of Weyl semimetals. Nature Communications. 7, 12492.
mla: Moll, Philip J. W., et al. “Magnetic Torque Anomaly in the Quantum Limit of
Weyl Semimetals.” Nature Communications, vol. 7, 12492, Springer Nature,
2016, doi:10.1038/ncomms12492.
short: P.J.W. Moll, A.C. Potter, N.L. Nair, B.J. Ramshaw, K.A. Modic, S. Riggs,
B. Zeng, N.J. Ghimire, E.D. Bauer, R. Kealhofer, F. Ronning, J.G. Analytis, Nature
Communications 7 (2016).
date_created: 2019-11-19T13:20:53Z
date_published: 2016-08-22T00:00:00Z
date_updated: 2021-01-12T08:11:40Z
day: '22'
ddc:
- '530'
doi: 10.1038/ncomms12492
extern: '1'
file:
- access_level: open_access
checksum: e3272ed18d22187406b30be48a56e7b2
content_type: application/pdf
creator: dernst
date_created: 2019-11-26T12:52:19Z
date_updated: 2020-07-14T12:47:48Z
file_id: '7114'
file_name: 2016_NatureComm_Moll.pdf
file_size: 663911
relation: main_file
file_date_updated: 2020-07-14T12:47:48Z
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Magnetic torque anomaly in the quantum limit of Weyl semimetals
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2016'
...
---
_id: '7069'
abstract:
- lang: eng
text: The observation of a reconstructed Fermi surface via quantum oscillations
in hole-doped cuprates opened a path towards identifying broken symmetry states
in the pseudogap regime. However, such an identification has remained inconclusive
due to the multi-frequency quantum oscillation spectra and complications accounting
for bilayer effects in most studies. We overcome these impediments with high-resolution
measurements on the structurally simpler cuprate HgBa2CuO4+δ (Hg1201), which features
one CuO2 plane per primitive unit cell. We find only a single oscillatory component
with no signatures of magnetic breakdown tunnelling to additional orbits. Therefore,
the Fermi surface comprises a single quasi-two-dimensional pocket. Quantitative
modelling of these results indicates that a biaxial charge density wave within
each CuO2 plane is responsible for the reconstruction and rules out criss-crossed
charge stripes between layers as a viable alternative in Hg1201. Lastly, we determine
that the characteristic gap between reconstructed pockets is a significant fraction
of the pseudogap energy.
article_number: '12244'
article_processing_charge: No
article_type: original
author:
- first_name: M. K.
full_name: Chan, M. K.
last_name: Chan
- first_name: N.
full_name: Harrison, N.
last_name: Harrison
- first_name: R. D.
full_name: McDonald, R. D.
last_name: McDonald
- first_name: B. J.
full_name: Ramshaw, B. J.
last_name: Ramshaw
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: N.
full_name: Barišić, N.
last_name: Barišić
- first_name: M.
full_name: Greven, M.
last_name: Greven
citation:
ama: Chan MK, Harrison N, McDonald RD, et al. Single reconstructed Fermi surface
pocket in an underdoped single-layer cuprate superconductor. Nature Communications.
2016;7. doi:10.1038/ncomms12244
apa: Chan, M. K., Harrison, N., McDonald, R. D., Ramshaw, B. J., Modic, K. A., Barišić,
N., & Greven, M. (2016). Single reconstructed Fermi surface pocket in an underdoped
single-layer cuprate superconductor. Nature Communications. Springer Nature.
https://doi.org/10.1038/ncomms12244
chicago: Chan, M. K., N. Harrison, R. D. McDonald, B. J. Ramshaw, Kimberly A Modic,
N. Barišić, and M. Greven. “Single Reconstructed Fermi Surface Pocket in an Underdoped
Single-Layer Cuprate Superconductor.” Nature Communications. Springer Nature,
2016. https://doi.org/10.1038/ncomms12244.
ieee: M. K. Chan et al., “Single reconstructed Fermi surface pocket in an
underdoped single-layer cuprate superconductor,” Nature Communications,
vol. 7. Springer Nature, 2016.
ista: Chan MK, Harrison N, McDonald RD, Ramshaw BJ, Modic KA, Barišić N, Greven
M. 2016. Single reconstructed Fermi surface pocket in an underdoped single-layer
cuprate superconductor. Nature Communications. 7, 12244.
mla: Chan, M. K., et al. “Single Reconstructed Fermi Surface Pocket in an Underdoped
Single-Layer Cuprate Superconductor.” Nature Communications, vol. 7, 12244,
Springer Nature, 2016, doi:10.1038/ncomms12244.
short: M.K. Chan, N. Harrison, R.D. McDonald, B.J. Ramshaw, K.A. Modic, N. Barišić,
M. Greven, Nature Communications 7 (2016).
date_created: 2019-11-19T13:21:23Z
date_published: 2016-07-22T00:00:00Z
date_updated: 2021-01-12T08:11:41Z
day: '22'
doi: 10.1038/ncomms12244
extern: '1'
intvolume: ' 7'
language:
- iso: eng
month: '07'
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Single reconstructed Fermi surface pocket in an underdoped single-layer cuprate
superconductor
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2016'
...
---
_id: '7141'
article_processing_charge: No
article_type: original
author:
- first_name: Chiara
full_name: Rolando, Chiara
last_name: Rolando
- first_name: Andrea
full_name: Erni, Andrea
last_name: Erni
- first_name: Alice
full_name: Grison, Alice
last_name: Grison
- first_name: Robert J
full_name: Beattie, Robert J
id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
last_name: Beattie
orcid: 0000-0002-8483-8753
- first_name: Anna
full_name: Engler, Anna
last_name: Engler
- first_name: Paul J.
full_name: Gokhale, Paul J.
last_name: Gokhale
- first_name: Marta
full_name: Milo, Marta
last_name: Milo
- first_name: Thomas
full_name: Wegleiter, Thomas
last_name: Wegleiter
- first_name: Sebastian
full_name: Jessberger, Sebastian
last_name: Jessberger
- first_name: Verdon
full_name: Taylor, Verdon
last_name: Taylor
citation:
ama: Rolando C, Erni A, Grison A, et al. Multipotency of adult hippocampal NSCs
in vivo is restricted by Drosha/NFIB. Cell Stem Cell. 2016;19(5):653-662.
doi:10.1016/j.stem.2016.07.003
apa: Rolando, C., Erni, A., Grison, A., Beattie, R. J., Engler, A., Gokhale, P.
J., … Taylor, V. (2016). Multipotency of adult hippocampal NSCs in vivo is restricted
by Drosha/NFIB. Cell Stem Cell. Elsevier. https://doi.org/10.1016/j.stem.2016.07.003
chicago: Rolando, Chiara, Andrea Erni, Alice Grison, Robert J Beattie, Anna Engler,
Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon
Taylor. “Multipotency of Adult Hippocampal NSCs in Vivo Is Restricted by Drosha/NFIB.”
Cell Stem Cell. Elsevier, 2016. https://doi.org/10.1016/j.stem.2016.07.003.
ieee: C. Rolando et al., “Multipotency of adult hippocampal NSCs in vivo
is restricted by Drosha/NFIB,” Cell Stem Cell, vol. 19, no. 5. Elsevier,
pp. 653–662, 2016.
ista: Rolando C, Erni A, Grison A, Beattie RJ, Engler A, Gokhale PJ, Milo M, Wegleiter
T, Jessberger S, Taylor V. 2016. Multipotency of adult hippocampal NSCs in vivo
is restricted by Drosha/NFIB. Cell Stem Cell. 19(5), 653–662.
mla: Rolando, Chiara, et al. “Multipotency of Adult Hippocampal NSCs in Vivo Is
Restricted by Drosha/NFIB.” Cell Stem Cell, vol. 19, no. 5, Elsevier, 2016,
pp. 653–62, doi:10.1016/j.stem.2016.07.003.
short: C. Rolando, A. Erni, A. Grison, R.J. Beattie, A. Engler, P.J. Gokhale, M.
Milo, T. Wegleiter, S. Jessberger, V. Taylor, Cell Stem Cell 19 (2016) 653–662.
date_created: 2019-11-28T13:09:09Z
date_published: 2016-08-16T00:00:00Z
date_updated: 2021-01-12T08:12:00Z
day: '16'
doi: 10.1016/j.stem.2016.07.003
extern: '1'
intvolume: ' 19'
issue: '5'
language:
- iso: eng
month: '08'
oa_version: None
page: 653-662
publication: Cell Stem Cell
publication_identifier:
issn:
- 1934-5909
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Multipotency of adult hippocampal NSCs in vivo is restricted by Drosha/NFIB
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2016'
...
---
_id: '7279'
abstract:
- lang: eng
text: Kinetics of electrochemical reactions are several orders of magnitude slower
in solids than in liquids as a result of the much lower ion diffusivity. Yet,
the solid state maximizes the density of redox species, which is at least two
orders of magnitude lower in liquids because of solubility limitations. With regard
to electrochemical energy storage devices, this leads to high-energy batteries
with limited power and high-power supercapacitors with a well-known energy deficiency.
For such devices the ideal system should endow the liquid state with a density
of redox species close to the solid state. Here we report an approach based on
biredox ionic liquids to achieve bulk-like redox density at liquid-like fast kinetics.
The cation and anion of these biredox ionic liquids bear moieties that undergo
very fast reversible redox reactions. As a first demonstration of their potential
for high-capacity/high-rate charge storage, we used them in redox supercapacitors.
These ionic liquids are able to decouple charge storage from an ion-accessible
electrode surface, by storing significant charge in the pores of the electrodes,
to minimize self-discharge and leakage current as a result of retaining the redox
species in the pores, and to raise working voltage due to their wide electrochemical
window.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Laura
full_name: Coustan, Laura
last_name: Coustan
- first_name: Pierre
full_name: Lannelongue, Pierre
last_name: Lannelongue
- first_name: Dodzi
full_name: Zigah, Dodzi
last_name: Zigah
- first_name: Ahmad
full_name: Mehdi, Ahmad
last_name: Mehdi
- first_name: André
full_name: Vioux, André
last_name: Vioux
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Frédéric
full_name: Favier, Frédéric
last_name: Favier
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
citation:
ama: Mourad E, Coustan L, Lannelongue P, et al. Biredox ionic liquids with solid-like
redox density in the liquid state for high-energy supercapacitors. Nature Materials.
2016;16(4):446-453. doi:10.1038/nmat4808
apa: Mourad, E., Coustan, L., Lannelongue, P., Zigah, D., Mehdi, A., Vioux, A.,
… Fontaine, O. (2016). Biredox ionic liquids with solid-like redox density in
the liquid state for high-energy supercapacitors. Nature Materials. Springer
Nature. https://doi.org/10.1038/nmat4808
chicago: Mourad, Eléonore, Laura Coustan, Pierre Lannelongue, Dodzi Zigah, Ahmad
Mehdi, André Vioux, Stefan Alexander Freunberger, Frédéric Favier, and Olivier
Fontaine. “Biredox Ionic Liquids with Solid-like Redox Density in the Liquid State
for High-Energy Supercapacitors.” Nature Materials. Springer Nature, 2016.
https://doi.org/10.1038/nmat4808.
ieee: E. Mourad et al., “Biredox ionic liquids with solid-like redox density
in the liquid state for high-energy supercapacitors,” Nature Materials,
vol. 16, no. 4. Springer Nature, pp. 446–453, 2016.
ista: Mourad E, Coustan L, Lannelongue P, Zigah D, Mehdi A, Vioux A, Freunberger
SA, Favier F, Fontaine O. 2016. Biredox ionic liquids with solid-like redox density
in the liquid state for high-energy supercapacitors. Nature Materials. 16(4),
446–453.
mla: Mourad, Eléonore, et al. “Biredox Ionic Liquids with Solid-like Redox Density
in the Liquid State for High-Energy Supercapacitors.” Nature Materials,
vol. 16, no. 4, Springer Nature, 2016, pp. 446–53, doi:10.1038/nmat4808.
short: E. Mourad, L. Coustan, P. Lannelongue, D. Zigah, A. Mehdi, A. Vioux, S.A.
Freunberger, F. Favier, O. Fontaine, Nature Materials 16 (2016) 446–453.
date_created: 2020-01-15T07:27:54Z
date_published: 2016-11-28T00:00:00Z
date_updated: 2021-01-12T08:12:43Z
day: '28'
doi: 10.1038/nmat4808
extern: '1'
external_id:
arxiv:
- '1711.11518'
intvolume: ' 16'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1711.11518
month: '11'
oa: 1
oa_version: Preprint
page: 446-453
publication: Nature Materials
publication_identifier:
issn:
- 1476-1122
- 1476-4660
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Biredox ionic liquids with solid-like redox density in the liquid state for
high-energy supercapacitors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2016'
...
---
_id: '7293'
abstract:
- lang: eng
text: If proton exchange membrane fuel cells (PEMFC) are ever to succeed in sustainable
energy landscape as a potential zero emission technology, it is inevitable to
reduce electricity production cost associated mainly with its MEAs, cell hardware
and gas storage units. We demonstrate a diverse strategy for achieving this target
with a concomitant amplification of its specific energy and power, by rolling
a thin graphene oxide (GO) based MEA alone into a tubular and air breathing architecture
with internal fuel storage. The unique properties of GO being a barrier for molecular
fuels and proton conducting to construct a GO based cylindrical MEA. This makes
the tubular PEMFC ∼75 times lighter, featuring ∼37 and ∼92 times respectively,
the power and energy per overall weight, making it a potential candidate for portable
applications. The intrinsic electrochemical kinetics at the three-phase boundary
are somewhat affected by the bending of the MEA, albeit at overall reduction in
power production cost.
article_processing_charge: No
article_type: original
author:
- first_name: Ravikumar
full_name: Thimmappa, Ravikumar
last_name: Thimmappa
- first_name: Mruthyunjayachari
full_name: Chattanahalli Devendrachari, Mruthyunjayachari
last_name: Chattanahalli Devendrachari
- first_name: Shahid
full_name: Shafi, Shahid
last_name: Shafi
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Musthafa
full_name: Ottakam Thotiyl, Musthafa
last_name: Ottakam Thotiyl
citation:
ama: Thimmappa R, Chattanahalli Devendrachari M, Shafi S, Freunberger SA, Ottakam
Thotiyl M. Proton conducting hollow graphene oxide cylinder as molecular fuel
barrier for tubular H2-air fuel cell. International Journal of Hydrogen Energy.
2016;41(47):22305-22315. doi:10.1016/j.ijhydene.2016.08.057
apa: Thimmappa, R., Chattanahalli Devendrachari, M., Shafi, S., Freunberger, S.
A., & Ottakam Thotiyl, M. (2016). Proton conducting hollow graphene oxide
cylinder as molecular fuel barrier for tubular H2-air fuel cell. International
Journal of Hydrogen Energy. Elsevier. https://doi.org/10.1016/j.ijhydene.2016.08.057
chicago: Thimmappa, Ravikumar, Mruthyunjayachari Chattanahalli Devendrachari, Shahid
Shafi, Stefan Alexander Freunberger, and Musthafa Ottakam Thotiyl. “Proton Conducting
Hollow Graphene Oxide Cylinder as Molecular Fuel Barrier for Tubular H2-Air Fuel
Cell.” International Journal of Hydrogen Energy. Elsevier, 2016. https://doi.org/10.1016/j.ijhydene.2016.08.057.
ieee: R. Thimmappa, M. Chattanahalli Devendrachari, S. Shafi, S. A. Freunberger,
and M. Ottakam Thotiyl, “Proton conducting hollow graphene oxide cylinder as molecular
fuel barrier for tubular H2-air fuel cell,” International Journal of Hydrogen
Energy, vol. 41, no. 47. Elsevier, pp. 22305–22315, 2016.
ista: Thimmappa R, Chattanahalli Devendrachari M, Shafi S, Freunberger SA, Ottakam
Thotiyl M. 2016. Proton conducting hollow graphene oxide cylinder as molecular
fuel barrier for tubular H2-air fuel cell. International Journal of Hydrogen Energy.
41(47), 22305–22315.
mla: Thimmappa, Ravikumar, et al. “Proton Conducting Hollow Graphene Oxide Cylinder
as Molecular Fuel Barrier for Tubular H2-Air Fuel Cell.” International Journal
of Hydrogen Energy, vol. 41, no. 47, Elsevier, 2016, pp. 22305–15, doi:10.1016/j.ijhydene.2016.08.057.
short: R. Thimmappa, M. Chattanahalli Devendrachari, S. Shafi, S.A. Freunberger,
M. Ottakam Thotiyl, International Journal of Hydrogen Energy 41 (2016) 22305–22315.
date_created: 2020-01-15T12:15:57Z
date_published: 2016-12-21T00:00:00Z
date_updated: 2021-01-12T08:12:49Z
day: '21'
doi: 10.1016/j.ijhydene.2016.08.057
extern: '1'
intvolume: ' 41'
issue: '47'
language:
- iso: eng
month: '12'
oa_version: None
page: 22305-22315
publication: International Journal of Hydrogen Energy
publication_identifier:
issn:
- 0360-3199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Proton conducting hollow graphene oxide cylinder as molecular fuel barrier
for tubular H2-air fuel cell
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2016'
...
---
_id: '7294'
abstract:
- lang: eng
text: Mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres were prepared by
non-hydrolytic sol–gel from TiCl4, VOCl3, and iPr2O at 110 °C without any solvent
or additives. The samples were characterized by elemental analysis, X-ray diffraction,
Raman spectroscopy, scanning electron microscopy, nitrogen physisorption, and
impedance measurements. At low vanadium loadings, only TiO2 anatase was detected,
and V2O5 scherbinaite was also detected at high vanadium loadings. The texture
of the samples depended on the V loading, but all the samples appeared built of
primary nanoparticles (≈10–20 nm in size) that aggregate to form mesoporous micron-sized
spheres. The lithium insertion properties of these materials were evaluated by
galvanostatic measurements taken using coin-type cells, in view of their application
as electrode for rechargeable Li-ion batteries. The mesoporous TiO2 microspheres
showed good performances, with a specific reversible capacity of 145 and 128 mAh
g−1 at C/2 and C, respectively (C = 335.6 mA g−1), good coulombic efficiency,
and a moderate capacity fade (6 %) from the 2nd to the 20th cycle at C/20. Although
the addition of V effectively increased the electronic conductivity of the powders,
the specific reversible capacity and cycling performances of the TiO2–V2O5 samples
were only minimally improved for a 5 at% V loading and were lower at higher V
loading.
article_processing_charge: No
article_type: original
author:
- first_name: A. M.
full_name: Escamilla-Pérez, A. M.
last_name: Escamilla-Pérez
- first_name: N.
full_name: Louvain, N.
last_name: Louvain
- first_name: M.
full_name: Kaschowitz, M.
last_name: Kaschowitz
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: O.
full_name: Fontaine, O.
last_name: Fontaine
- first_name: B.
full_name: Boury, B.
last_name: Boury
- first_name: N.
full_name: Brun, N.
last_name: Brun
- first_name: P. H.
full_name: Mutin, P. H.
last_name: Mutin
citation:
ama: Escamilla-Pérez AM, Louvain N, Kaschowitz M, et al. Lithium insertion properties
of mesoporous nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic
sol–gel. Journal of Sol-Gel Science and Technology. 2016;79(2):270-278.
doi:10.1007/s10971-016-4037-9
apa: Escamilla-Pérez, A. M., Louvain, N., Kaschowitz, M., Freunberger, S. A., Fontaine,
O., Boury, B., … Mutin, P. H. (2016). Lithium insertion properties of mesoporous
nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel.
Journal of Sol-Gel Science and Technology. Springer Nature. https://doi.org/10.1007/s10971-016-4037-9
chicago: Escamilla-Pérez, A. M., N. Louvain, M. Kaschowitz, Stefan Alexander Freunberger,
O. Fontaine, B. Boury, N. Brun, and P. H. Mutin. “Lithium Insertion Properties
of Mesoporous Nanocrystalline TiO2 and TiO2–V2O5 Microspheres Prepared by Non-Hydrolytic
Sol–Gel.” Journal of Sol-Gel Science and Technology. Springer Nature, 2016.
https://doi.org/10.1007/s10971-016-4037-9.
ieee: A. M. Escamilla-Pérez et al., “Lithium insertion properties of mesoporous
nanocrystalline TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel,”
Journal of Sol-Gel Science and Technology, vol. 79, no. 2. Springer Nature,
pp. 270–278, 2016.
ista: Escamilla-Pérez AM, Louvain N, Kaschowitz M, Freunberger SA, Fontaine O, Boury
B, Brun N, Mutin PH. 2016. Lithium insertion properties of mesoporous nanocrystalline
TiO2 and TiO2–V2O5 microspheres prepared by non-hydrolytic sol–gel. Journal of
Sol-Gel Science and Technology. 79(2), 270–278.
mla: Escamilla-Pérez, A. M., et al. “Lithium Insertion Properties of Mesoporous
Nanocrystalline TiO2 and TiO2–V2O5 Microspheres Prepared by Non-Hydrolytic Sol–Gel.”
Journal of Sol-Gel Science and Technology, vol. 79, no. 2, Springer Nature,
2016, pp. 270–78, doi:10.1007/s10971-016-4037-9.
short: A.M. Escamilla-Pérez, N. Louvain, M. Kaschowitz, S.A. Freunberger, O. Fontaine,
B. Boury, N. Brun, P.H. Mutin, Journal of Sol-Gel Science and Technology 79 (2016)
270–278.
date_created: 2020-01-15T12:16:08Z
date_published: 2016-04-08T00:00:00Z
date_updated: 2021-01-12T08:12:49Z
day: '08'
doi: 10.1007/s10971-016-4037-9
extern: '1'
intvolume: ' 79'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 270-278
publication: Journal of Sol-Gel Science and Technology
publication_identifier:
issn:
- 0928-0707
- 1573-4846
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Lithium insertion properties of mesoporous nanocrystalline TiO2 and TiO2–V2O5
microspheres prepared by non-hydrolytic sol–gel
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2016'
...
---
_id: '7295'
abstract:
- lang: eng
text: Redox ionic liquids consisting of ions bearing redox moieties are receiving
increasing interest in electrochemical applications, as they associate electroactive
properties with the classical properties of ionic liquids. Here, biredox ionic
liquid electrolytes are described in which both anion and cation are functionalized
with anthraquinone and 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) groups, respectively.
In-depth investigations based on crossed experimental and theoretical studies
were carried out to elucidate how the bulkiness of ions bearing a redox moiety
impacted electron and mass transfers, and accordingly the efficiency of electrochemical
devices. The values of solvated radii of different redox ions, as well as the
related kinetic constants, were extracted from cyclic voltammetry experiments.
Reformulating the basic relations of electron transfer theory (based on Marcus-Hush
theory) evidenced that in such redox species, with an unsymmetrical located redox
centre, the electron transfer was not governed by the overall size of the solvated
redox species, but rather by the radius of the redox active subunit, which takes
preferential orientation towards the surface, thus allowing higher kinetic constants
than what classical theory would predict. This vision opens ample opportunities
for biredox ILs as electrolytes in electrochemical devices.
article_processing_charge: No
article_type: original
author:
- first_name: Eléonore
full_name: Mourad, Eléonore
last_name: Mourad
- first_name: Laura
full_name: Coustan, Laura
last_name: Coustan
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Ahmad
full_name: Mehdi, Ahmad
last_name: Mehdi
- first_name: André
full_name: Vioux, André
last_name: Vioux
- first_name: Frédérique
full_name: Favier, Frédérique
last_name: Favier
- first_name: Olivier
full_name: Fontaine, Olivier
last_name: Fontaine
citation:
ama: 'Mourad E, Coustan L, Freunberger SA, et al. Biredox ionic liquids: Electrochemical
investigation and impact of ion size on electron transfer. Electrochimica Acta.
2016;206(7):513-523. doi:10.1016/j.electacta.2016.02.211'
apa: 'Mourad, E., Coustan, L., Freunberger, S. A., Mehdi, A., Vioux, A., Favier,
F., & Fontaine, O. (2016). Biredox ionic liquids: Electrochemical investigation
and impact of ion size on electron transfer. Electrochimica Acta. Elsevier.
https://doi.org/10.1016/j.electacta.2016.02.211'
chicago: 'Mourad, Eléonore, Laura Coustan, Stefan Alexander Freunberger, Ahmad Mehdi,
André Vioux, Frédérique Favier, and Olivier Fontaine. “Biredox Ionic Liquids:
Electrochemical Investigation and Impact of Ion Size on Electron Transfer.” Electrochimica
Acta. Elsevier, 2016. https://doi.org/10.1016/j.electacta.2016.02.211.'
ieee: 'E. Mourad et al., “Biredox ionic liquids: Electrochemical investigation
and impact of ion size on electron transfer,” Electrochimica Acta, vol.
206, no. 7. Elsevier, pp. 513–523, 2016.'
ista: 'Mourad E, Coustan L, Freunberger SA, Mehdi A, Vioux A, Favier F, Fontaine
O. 2016. Biredox ionic liquids: Electrochemical investigation and impact of ion
size on electron transfer. Electrochimica Acta. 206(7), 513–523.'
mla: 'Mourad, Eléonore, et al. “Biredox Ionic Liquids: Electrochemical Investigation
and Impact of Ion Size on Electron Transfer.” Electrochimica Acta, vol.
206, no. 7, Elsevier, 2016, pp. 513–23, doi:10.1016/j.electacta.2016.02.211.'
short: E. Mourad, L. Coustan, S.A. Freunberger, A. Mehdi, A. Vioux, F. Favier, O.
Fontaine, Electrochimica Acta 206 (2016) 513–523.
date_created: 2020-01-15T12:16:17Z
date_published: 2016-07-10T00:00:00Z
date_updated: 2021-01-12T08:12:50Z
day: '10'
doi: 10.1016/j.electacta.2016.02.211
extern: '1'
intvolume: ' 206'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 513-523
publication: Electrochimica Acta
publication_identifier:
issn:
- 0013-4686
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Biredox ionic liquids: Electrochemical investigation and impact of ion size
on electron transfer'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 206
year: '2016'
...
---
_id: '7296'
abstract:
- lang: eng
text: Within the scope of developing a multi-physical model describing battery behavior
during and after the mechanical load (accelerations, intrusions) of a vehicle’s
high voltage battery, an internal short circuit model is of deep interest for
a virtual hazard assessment. The internal short resistance and the size of the
affected area must be known as a minimum for determining the released heat and,
in consequence, the temperatures. The internal short resistance of purpose-built
dummy pouch cells, filled with electrolyte-like solvent without conductive salt,
has thus been measured in a given short area under various compressive loads.
The resistances for different short scenarios obtained are analyzed and described
in a mathematical form. Short circuit experiments with dummy cells using an external
power source have also been carried out. This set-up allows the measurement of
the temperature evolution at a known current and a determination of the actual
short resistance. The post-mortem analysis of the samples shows a correlation
between the maximum temperatures, released short heat and the separator melt diameter.
article_number: '8'
article_processing_charge: No
article_type: original
author:
- first_name: Theo
full_name: Volck, Theo
last_name: Volck
- first_name: Wolfgang
full_name: Sinz, Wolfgang
last_name: Sinz
- first_name: Gregor
full_name: Gstrein, Gregor
last_name: Gstrein
- first_name: Christoph
full_name: Breitfuss, Christoph
last_name: Breitfuss
- first_name: Simon
full_name: Heindl, Simon
last_name: Heindl
- first_name: Hermann
full_name: Steffan, Hermann
last_name: Steffan
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
- first_name: Martin
full_name: Wilkening, Martin
last_name: Wilkening
- first_name: Marlena
full_name: Uitz, Marlena
last_name: Uitz
- first_name: Clemens
full_name: Fink, Clemens
last_name: Fink
- first_name: Alexander
full_name: Geier, Alexander
last_name: Geier
citation:
ama: Volck T, Sinz W, Gstrein G, et al. Method for determination of the internal
short resistance and heat evolution at different mechanical loads of a Lithium
ion battery cell based on dummy pouch cells. Batteries. 2016;2(2). doi:10.3390/batteries2020008
apa: Volck, T., Sinz, W., Gstrein, G., Breitfuss, C., Heindl, S., Steffan, H., …
Geier, A. (2016). Method for determination of the internal short resistance and
heat evolution at different mechanical loads of a Lithium ion battery cell based
on dummy pouch cells. Batteries. MDPI AG. https://doi.org/10.3390/batteries2020008
chicago: Volck, Theo, Wolfgang Sinz, Gregor Gstrein, Christoph Breitfuss, Simon
Heindl, Hermann Steffan, Stefan Alexander Freunberger, et al. “Method for Determination
of the Internal Short Resistance and Heat Evolution at Different Mechanical Loads
of a Lithium Ion Battery Cell Based on Dummy Pouch Cells.” Batteries. MDPI
AG, 2016. https://doi.org/10.3390/batteries2020008.
ieee: T. Volck et al., “Method for determination of the internal short resistance
and heat evolution at different mechanical loads of a Lithium ion battery cell
based on dummy pouch cells,” Batteries, vol. 2, no. 2. MDPI AG, 2016.
ista: Volck T, Sinz W, Gstrein G, Breitfuss C, Heindl S, Steffan H, Freunberger
SA, Wilkening M, Uitz M, Fink C, Geier A. 2016. Method for determination of the
internal short resistance and heat evolution at different mechanical loads of
a Lithium ion battery cell based on dummy pouch cells. Batteries. 2(2), 8.
mla: Volck, Theo, et al. “Method for Determination of the Internal Short Resistance
and Heat Evolution at Different Mechanical Loads of a Lithium Ion Battery Cell
Based on Dummy Pouch Cells.” Batteries, vol. 2, no. 2, 8, MDPI AG, 2016,
doi:10.3390/batteries2020008.
short: T. Volck, W. Sinz, G. Gstrein, C. Breitfuss, S. Heindl, H. Steffan, S.A.
Freunberger, M. Wilkening, M. Uitz, C. Fink, A. Geier, Batteries 2 (2016).
date_created: 2020-01-15T12:16:31Z
date_published: 2016-04-07T00:00:00Z
date_updated: 2021-01-12T08:12:50Z
day: '07'
doi: 10.3390/batteries2020008
extern: '1'
intvolume: ' 2'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: Published Version
publication: Batteries
publication_identifier:
issn:
- 2313-0105
publication_status: published
publisher: MDPI AG
quality_controlled: '1'
status: public
title: Method for determination of the internal short resistance and heat evolution
at different mechanical loads of a Lithium ion battery cell based on dummy pouch
cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2016'
...
---
_id: '7297'
abstract:
- lang: eng
text: Redox mediators facilitate the oxidation of the highly insulating discharge
product in metal–oxygen batteries during recharge and offer opportunities to achieve
high reversible capacities. Now a design principle for selecting redox mediators
that can recharge the batteries more efficiently is suggested.
article_number: '16074'
article_processing_charge: No
article_type: original
author:
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: 'Freunberger SA. Batteries: Charging ahead rationally. Nature Energy.
2016;1(6). doi:10.1038/nenergy.2016.74'
apa: 'Freunberger, S. A. (2016). Batteries: Charging ahead rationally. Nature
Energy. Springer Nature. https://doi.org/10.1038/nenergy.2016.74'
chicago: 'Freunberger, Stefan Alexander. “Batteries: Charging Ahead Rationally.”
Nature Energy. Springer Nature, 2016. https://doi.org/10.1038/nenergy.2016.74.'
ieee: 'S. A. Freunberger, “Batteries: Charging ahead rationally,” Nature Energy,
vol. 1, no. 6. Springer Nature, 2016.'
ista: 'Freunberger SA. 2016. Batteries: Charging ahead rationally. Nature Energy.
1(6), 16074.'
mla: 'Freunberger, Stefan Alexander. “Batteries: Charging Ahead Rationally.” Nature
Energy, vol. 1, no. 6, 16074, Springer Nature, 2016, doi:10.1038/nenergy.2016.74.'
short: S.A. Freunberger, Nature Energy 1 (2016).
date_created: 2020-01-15T12:16:40Z
date_published: 2016-05-23T00:00:00Z
date_updated: 2021-01-12T08:12:51Z
day: '23'
ddc:
- '540'
- '541'
- '547'
- '546'
doi: 10.1038/nenergy.2016.74
extern: '1'
file:
- access_level: open_access
checksum: d90d675947262f7437b483b251918df2
content_type: application/pdf
creator: sfreunbe
date_created: 2020-06-29T13:41:56Z
date_updated: 2020-07-14T12:47:55Z
file_id: '8047'
file_name: N&V Freunberger final.pdf
file_size: 197375
relation: main_file
file_date_updated: 2020-07-14T12:47:55Z
has_accepted_license: '1'
intvolume: ' 1'
issue: '6'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
publication: Nature Energy
publication_identifier:
issn:
- 2058-7546
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Batteries: Charging ahead rationally'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2016'
...
---
_id: '7298'
abstract:
- lang: eng
text: Lithium-ion batteries are in widespread use in electric vehicles and hybrid
vehicles. Besides features like energy density, cost, lifetime, and recyclability
the safety of a battery system is of prime importance. The separator material
impacts all these properties and requires therefore an informed selection. The
interplay between the mechanical and electrochemical properties as key selection
criteria is investigated. Mechanical properties were investigated using tensile
and puncture penetration tests at abuse relevant conditions. To investigate the
electrochemical performance in terms of effective conductivity a method based
on impedance spectroscopy was introduced. This methodology is applied to evaluate
ten commercial separators which allows for a trade-off analysis of mechanical
versus electrochemical performance. Based on the results, and in combination with
other factors, this offers an effective approach to select suitable separators
for automotive applications.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
full_name: Plaimer, Martin
last_name: Plaimer
- first_name: Christoph
full_name: Breitfuß, Christoph
last_name: Breitfuß
- first_name: Wolfgang
full_name: Sinz, Wolfgang
last_name: Sinz
- first_name: Simon F.
full_name: Heindl, Simon F.
last_name: Heindl
- first_name: Christian
full_name: Ellersdorfer, Christian
last_name: Ellersdorfer
- first_name: Hermann
full_name: Steffan, Hermann
last_name: Steffan
- first_name: Martin
full_name: Wilkening, Martin
last_name: Wilkening
- first_name: Volker
full_name: Hennige, Volker
last_name: Hennige
- first_name: Reinhard
full_name: Tatschl, Reinhard
last_name: Tatschl
- first_name: Alexander
full_name: Geier, Alexander
last_name: Geier
- first_name: Christian
full_name: Schramm, Christian
last_name: Schramm
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: 'Plaimer M, Breitfuß C, Sinz W, et al. Evaluating the trade-off between mechanical
and electrochemical performance of separators for lithium-ion batteries: Methodology
and application. Journal of Power Sources. 2016;306(2):702-710. doi:10.1016/j.jpowsour.2015.12.047'
apa: 'Plaimer, M., Breitfuß, C., Sinz, W., Heindl, S. F., Ellersdorfer, C., Steffan,
H., … Freunberger, S. A. (2016). Evaluating the trade-off between mechanical and
electrochemical performance of separators for lithium-ion batteries: Methodology
and application. Journal of Power Sources. Elsevier. https://doi.org/10.1016/j.jpowsour.2015.12.047'
chicago: 'Plaimer, Martin, Christoph Breitfuß, Wolfgang Sinz, Simon F. Heindl, Christian
Ellersdorfer, Hermann Steffan, Martin Wilkening, et al. “Evaluating the Trade-off
between Mechanical and Electrochemical Performance of Separators for Lithium-Ion
Batteries: Methodology and Application.” Journal of Power Sources. Elsevier,
2016. https://doi.org/10.1016/j.jpowsour.2015.12.047.'
ieee: 'M. Plaimer et al., “Evaluating the trade-off between mechanical and
electrochemical performance of separators for lithium-ion batteries: Methodology
and application,” Journal of Power Sources, vol. 306, no. 2. Elsevier,
pp. 702–710, 2016.'
ista: 'Plaimer M, Breitfuß C, Sinz W, Heindl SF, Ellersdorfer C, Steffan H, Wilkening
M, Hennige V, Tatschl R, Geier A, Schramm C, Freunberger SA. 2016. Evaluating
the trade-off between mechanical and electrochemical performance of separators
for lithium-ion batteries: Methodology and application. Journal of Power Sources.
306(2), 702–710.'
mla: 'Plaimer, Martin, et al. “Evaluating the Trade-off between Mechanical and Electrochemical
Performance of Separators for Lithium-Ion Batteries: Methodology and Application.”
Journal of Power Sources, vol. 306, no. 2, Elsevier, 2016, pp. 702–10,
doi:10.1016/j.jpowsour.2015.12.047.'
short: M. Plaimer, C. Breitfuß, W. Sinz, S.F. Heindl, C. Ellersdorfer, H. Steffan,
M. Wilkening, V. Hennige, R. Tatschl, A. Geier, C. Schramm, S.A. Freunberger,
Journal of Power Sources 306 (2016) 702–710.
date_created: 2020-01-15T12:16:51Z
date_published: 2016-02-29T00:00:00Z
date_updated: 2021-01-12T08:12:51Z
day: '29'
doi: 10.1016/j.jpowsour.2015.12.047
extern: '1'
intvolume: ' 306'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 702-710
publication: Journal of Power Sources
publication_identifier:
issn:
- 0378-7753
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Evaluating the trade-off between mechanical and electrochemical performance
of separators for lithium-ion batteries: Methodology and application'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 306
year: '2016'
...
---
_id: '7599'
abstract:
- lang: eng
text: Normal leaf margin development is important for leaf morphogenesis and contributes
to diverse leaf shapes in higher plants. We here show the crucial roles of an
atypical type II phosphatidylinositol 4-kinase, PI4Kγ5, in Arabidopsis leaf margin
development. PI4Kγ5 presents a dynamics expression pattern along with leaf development
and a T-DNA mutant lacking PI4Kγ5, pi4kγ5–1, presents serrated leaves, which is
resulted from the accelerated cell division and increased auxin concentration
at serration tips. Studies revealed that PI4Kγ5 interacts with and phosphorylates
a membrane-bound NAC transcription factor, ANAC078. Previous studies demonstrated
that membrane-bound transcription factors regulate gene transcription by undergoing
proteolytic process to translocate into nucleus, and ANAC078 undergoes proteolysis
by cleaving off the transmembrane region and carboxyl terminal. Western blot analysis
indeed showed that ANAC078 deleting of carboxyl terminal is significantly reduced
in pi4kγ5–1, indicating that PI4Kγ5 is important for the cleavage of ANAC078.
This is consistent with the subcellular localization observation showing that
fluorescence by GFP-ANAC078 is detected at plasma membrane but not nucleus in
pi4kγ5–1 mutant and that expression of ANAC078 deleting of carboxyl terminal,
driven by PI4Kγ5 promoter, could rescue the leaf serration defects of pi4kγ5–1.
Further analysis showed that ANAC078 suppresses the auxin synthesis by directly
binding and regulating the expression of auxin synthesis-related genes. These
results indicate that PI4Kγ5 interacts with ANAC078 to negatively regulate auxin
synthesis and hence influences cell proliferation and leaf development, providing
informative clues for the regulation of in situ auxin synthesis and cell division,
as well as the cleavage and functional mechanism of membrane-bound transcription
factors.
article_number: e1006252
article_processing_charge: No
article_type: original
author:
- first_name: Yong
full_name: Tang, Yong
last_name: Tang
- first_name: Chun-Yan
full_name: Zhao, Chun-Yan
last_name: Zhao
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Hong-Wei
full_name: Xue, Hong-Wei
last_name: Xue
citation:
ama: Tang Y, Zhao C-Y, Tan S, Xue H-W. Arabidopsis type II phosphatidylinositol
4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through
interacting with membrane-bound transcription factor ANAC078. PLOS Genetics.
2016;12(8). doi:10.1371/journal.pgen.1006252
apa: Tang, Y., Zhao, C.-Y., Tan, S., & Xue, H.-W. (2016). Arabidopsis type II
phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin
development through interacting with membrane-bound transcription factor ANAC078.
PLOS Genetics. Public Library of Science. https://doi.org/10.1371/journal.pgen.1006252
chicago: Tang, Yong, Chun-Yan Zhao, Shutang Tan, and Hong-Wei Xue. “Arabidopsis
Type II Phosphatidylinositol 4-Kinase PI4Kγ5 Regulates Auxin Biosynthesis and
Leaf Margin Development through Interacting with Membrane-Bound Transcription
Factor ANAC078.” PLOS Genetics. Public Library of Science, 2016. https://doi.org/10.1371/journal.pgen.1006252.
ieee: Y. Tang, C.-Y. Zhao, S. Tan, and H.-W. Xue, “Arabidopsis type II phosphatidylinositol
4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through
interacting with membrane-bound transcription factor ANAC078,” PLOS Genetics,
vol. 12, no. 8. Public Library of Science, 2016.
ista: Tang Y, Zhao C-Y, Tan S, Xue H-W. 2016. Arabidopsis type II phosphatidylinositol
4-kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through
interacting with membrane-bound transcription factor ANAC078. PLOS Genetics. 12(8),
e1006252.
mla: Tang, Yong, et al. “Arabidopsis Type II Phosphatidylinositol 4-Kinase PI4Kγ5
Regulates Auxin Biosynthesis and Leaf Margin Development through Interacting with
Membrane-Bound Transcription Factor ANAC078.” PLOS Genetics, vol. 12, no.
8, e1006252, Public Library of Science, 2016, doi:10.1371/journal.pgen.1006252.
short: Y. Tang, C.-Y. Zhao, S. Tan, H.-W. Xue, PLOS Genetics 12 (2016).
date_created: 2020-03-21T16:08:33Z
date_published: 2016-08-16T00:00:00Z
date_updated: 2021-01-12T08:14:25Z
day: '16'
ddc:
- '580'
doi: 10.1371/journal.pgen.1006252
extern: '1'
file:
- access_level: open_access
checksum: ff0ab9a6bed11cda800a6e59820866a0
content_type: application/pdf
creator: dernst
date_created: 2020-03-23T12:15:31Z
date_updated: 2020-07-14T12:48:01Z
file_id: '7612'
file_name: 2016_PlosGenetics_Tang.PDF
file_size: 3266119
relation: main_file
file_date_updated: 2020-07-14T12:48:01Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
publication: PLOS Genetics
publication_identifier:
issn:
- 1553-7404
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
status: public
title: Arabidopsis type II phosphatidylinositol 4-kinase PI4Kγ5 regulates auxin biosynthesis
and leaf margin development through interacting with membrane-bound transcription
factor ANAC078
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2016'
...
---
_id: '7734'
abstract:
- lang: eng
text: "Importance: Considerable partner resemblances have been found for a wide
range of psychiatric disorders, meaning that partners of affected individuals
have an increased risk of being affected compared with partners of unaffected
individuals. If this resemblance is reflected in genetic similarity between partners,
genetic risk is anticipated to accumulate in offspring, but these potential consequences
have not been quantified and have been left implicit.\r\n\r\nObservations: The
anticipated consequences of partner resemblance on prevalence and heritability
of psychiatric traits in the offspring generation were modeled for disorders with
varying heritabilities, population prevalence (lifetime risk), and magnitudes
of partner resemblance. These models facilitate interpretation for a wide range
of psychiatric disorders, such as autism, schizophrenia, and depression. The genetic
consequences of partner resemblance are most pronounced when attributable to phenotypic
assortment (driven by the psychiatric trait). Phenotypic assortment results in
increased genetic variance in the offspring generation, which may result in increased
heritability and population prevalence. These consequences add generation after
generation to a limit, but assortative mating is unlikely to balance the impact
of reduced fecundity of patients with psychiatric disorders in the long term.
This modeling suggests that the heritabilities of psychiatric disorders are unlikely
to increase by more than 5% from 1 generation of assortative mating (maximally
13% across multiple generations). The population prevalence will increase most
for less common disorders with high heritability; for example, the prevalence
of autism might increase by 1.5-fold after 1 generation of assortative mating
(≥2.4-fold in the long term) depending on several assumptions.\r\n\r\nConclusions
and Relevance: The considerable partner resemblances found for psychiatric disorders
deserve more detailed interpretation than has been provided thus far. Although
the limitations of modeling are emphasized, the anticipated consequences are at
most modest for the heritability but may be considerable for the population prevalence
of rare disorders with a high heritability."
article_processing_charge: No
article_type: original
author:
- first_name: Wouter J.
full_name: Peyrot, Wouter J.
last_name: Peyrot
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Brenda W. J. H.
full_name: Penninx, Brenda W. J. H.
last_name: Penninx
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
citation:
ama: Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. Exploring boundaries for the
genetic consequences of assortative mating for psychiatric traits. JAMA Psychiatry.
2016;73(11):1189-1195. doi:10.1001/jamapsychiatry.2016.2566
apa: Peyrot, W. J., Robinson, M. R., Penninx, B. W. J. H., & Wray, N. R. (2016).
Exploring boundaries for the genetic consequences of assortative mating for psychiatric
traits. JAMA Psychiatry. American Medical Association. https://doi.org/10.1001/jamapsychiatry.2016.2566
chicago: Peyrot, Wouter J., Matthew Richard Robinson, Brenda W. J. H. Penninx, and
Naomi R. Wray. “Exploring Boundaries for the Genetic Consequences of Assortative
Mating for Psychiatric Traits.” JAMA Psychiatry. American Medical Association,
2016. https://doi.org/10.1001/jamapsychiatry.2016.2566.
ieee: W. J. Peyrot, M. R. Robinson, B. W. J. H. Penninx, and N. R. Wray, “Exploring
boundaries for the genetic consequences of assortative mating for psychiatric
traits,” JAMA Psychiatry, vol. 73, no. 11. American Medical Association,
pp. 1189–1195, 2016.
ista: Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. 2016. Exploring boundaries
for the genetic consequences of assortative mating for psychiatric traits. JAMA
Psychiatry. 73(11), 1189–1195.
mla: Peyrot, Wouter J., et al. “Exploring Boundaries for the Genetic Consequences
of Assortative Mating for Psychiatric Traits.” JAMA Psychiatry, vol. 73,
no. 11, American Medical Association, 2016, pp. 1189–95, doi:10.1001/jamapsychiatry.2016.2566.
short: W.J. Peyrot, M.R. Robinson, B.W.J.H. Penninx, N.R. Wray, JAMA Psychiatry
73 (2016) 1189–1195.
date_created: 2020-04-30T10:48:41Z
date_published: 2016-11-01T00:00:00Z
date_updated: 2021-01-12T08:15:11Z
day: '01'
doi: 10.1001/jamapsychiatry.2016.2566
extern: '1'
intvolume: ' 73'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1189-1195
publication: JAMA Psychiatry
publication_identifier:
issn:
- 2168-622X
publication_status: published
publisher: American Medical Association
quality_controlled: '1'
status: public
title: Exploring boundaries for the genetic consequences of assortative mating for
psychiatric traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 73
year: '2016'
...