---
_id: '1145'
abstract:
- lang: eng
text: Auxin directs plant ontogenesis via differential accumulation within tissues
depending largely on the activity of PIN proteins that mediate auxin efflux from
cells and its directional cell-to-cell transport. Regardless of the developmental
importance of PINs, the structure of these transporters is poorly characterized.
Here, we present experimental data concerning protein topology of plasma membrane-localized
PINs. Utilizing approaches based on pH-dependent quenching of fluorescent reporters
combined with immunolocalization techniques, we mapped the membrane topology of
PINs and further cross-validated our results using available topology modeling
software. We delineated the topology of PIN1 with two transmembrane (TM) bundles
of five α-helices linked by a large intracellular loop and a C-terminus positioned
outside the cytoplasm. Using constraints derived from our experimental data, we
also provide an updated position of helical regions generating a verisimilitude
model of PIN1. Since the canonical long PINs show a high degree of conservation
in TM domains and auxin transport capacity has been demonstrated for Arabidopsis
representatives of this group, this empirically enhanced topological model of
PIN1 will be an important starting point for further studies on PIN structure–function
relationships. In addition, we have established protocols that can be used to
probe the topology of other plasma membrane proteins in plants. © 2016 The Authors
acknowledgement: This research has been financially supported by the Ministry of Education,
Youth and Sports of the Czech Republic under the project CEITEC 2020 (LQ1601) (T.N.,
M.Z., M.P., J.H.), Czech Science Foundation (13-40637S [J.F., M.Z.], 13-39982S [J.H.]);
Research Foundation Flanders (Grant number FWO09/PDO/196) (S.V.) and the European
Research Council (project ERC-2011-StG-20101109-PSDP) (J.F.). We thank David G.
Robinson and Ranjan Swarup for sharing published material; Maria Šimášková, Mamoona
Khan, Eva Benková for technical assistance; and R. Tejos, J. Kleine-Vehn, and E.
Feraru for helpful discussions.
author:
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Marta
full_name: Zwiewka, Marta
last_name: Zwiewka
- first_name: Markéta
full_name: Pernisová, Markéta
last_name: Pernisová
- first_name: Jan
full_name: Hejátko, Jan
last_name: Hejátko
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Nodzyński T, Vanneste S, Zwiewka M, Pernisová M, Hejátko J, Friml J. Enquiry
into the topology of plasma membrane localized PIN auxin transport components.
Molecular Plant. 2016;9(11):1504-1519. doi:10.1016/j.molp.2016.08.010
apa: Nodzyński, T., Vanneste, S., Zwiewka, M., Pernisová, M., Hejátko, J., &
Friml, J. (2016). Enquiry into the topology of plasma membrane localized PIN auxin
transport components. Molecular Plant. Cell Press. https://doi.org/10.1016/j.molp.2016.08.010
chicago: Nodzyński, Tomasz, Steffen Vanneste, Marta Zwiewka, Markéta Pernisová,
Jan Hejátko, and Jiří Friml. “Enquiry into the Topology of Plasma Membrane Localized
PIN Auxin Transport Components.” Molecular Plant. Cell Press, 2016. https://doi.org/10.1016/j.molp.2016.08.010.
ieee: T. Nodzyński, S. Vanneste, M. Zwiewka, M. Pernisová, J. Hejátko, and J. Friml,
“Enquiry into the topology of plasma membrane localized PIN auxin transport components,”
Molecular Plant, vol. 9, no. 11. Cell Press, pp. 1504–1519, 2016.
ista: Nodzyński T, Vanneste S, Zwiewka M, Pernisová M, Hejátko J, Friml J. 2016.
Enquiry into the topology of plasma membrane localized PIN auxin transport components.
Molecular Plant. 9(11), 1504–1519.
mla: Nodzyński, Tomasz, et al. “Enquiry into the Topology of Plasma Membrane Localized
PIN Auxin Transport Components.” Molecular Plant, vol. 9, no. 11, Cell
Press, 2016, pp. 1504–19, doi:10.1016/j.molp.2016.08.010.
short: T. Nodzyński, S. Vanneste, M. Zwiewka, M. Pernisová, J. Hejátko, J. Friml,
Molecular Plant 9 (2016) 1504–1519.
date_created: 2018-12-11T11:50:23Z
date_published: 2016-11-07T00:00:00Z
date_updated: 2021-01-12T06:48:37Z
day: '07'
ddc:
- '581'
department:
- _id: JiFr
doi: 10.1016/j.molp.2016.08.010
ec_funded: 1
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:22Z
date_updated: 2018-12-12T10:13:22Z
file_id: '5004'
file_name: IST-2017-746-v1+1_1-s2.0-S1674205216301915-main.pdf
file_size: 5005876
relation: main_file
file_date_updated: 2018-12-12T10:13:22Z
has_accepted_license: '1'
intvolume: ' 9'
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1504 - 1519
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Molecular Plant
publication_status: published
publisher: Cell Press
publist_id: '6213'
pubrep_id: '746'
quality_controlled: '1'
scopus_import: 1
status: public
title: Enquiry into the topology of plasma membrane localized PIN auxin transport
components
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2016'
...
---
_id: '1147'
abstract:
- lang: eng
text: Apical dominance is one of the fundamental developmental phenomena in plant
biology, which determines the overall architecture of aerial plant parts. Here
we show apex decapitation activated competition for dominance in adjacent upper
and lower axillary buds. A two-nodal-bud pea (Pisum sativum L.) was used as a
model system to monitor and assess auxin flow, auxin transport channels, and dormancy
and initiation status of axillary buds. Auxin flow was manipulated by lateral
stem wounds or chemically by auxin efflux inhibitors 2,3,5-triiodobenzoic acid
(TIBA), 1-N-naphtylphtalamic acid (NPA), or protein synthesis inhibitor cycloheximide
(CHX) treatments, which served to interfere with axillary bud competition. Redirecting
auxin flow to different points influenced which bud formed the outgrowing and
dominant shoot. The obtained results proved that competition between upper and
lower axillary buds as secondary auxin sources is based on the same auxin canalization
principle that operates between the shoot apex and axillary bud. © The Author(s)
2016.
acknowledgement: This research was carried out under the project CEITEC 2020 (LQ1601)
with financial support from the Ministry of Education, Youth and Sports of the Czech
Republic under the National Sustainability Programme II., supported by the project
“CEITEC–Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) and the
Agronomy faculty grant from Mendel University “IGA AF MENDELU” (IP 14/2013).
article_number: '35955'
author:
- first_name: Jozef
full_name: Balla, Jozef
last_name: Balla
- first_name: Zuzana
full_name: Medved'Ová, Zuzana
last_name: Medved'Ová
- first_name: Petr
full_name: Kalousek, Petr
last_name: Kalousek
- first_name: Natálie
full_name: Matiješčuková, Natálie
last_name: Matiješčuková
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Vilém
full_name: Reinöhl, Vilém
last_name: Reinöhl
- first_name: Stanislav
full_name: Procházka, Stanislav
last_name: Procházka
citation:
ama: Balla J, Medved’Ová Z, Kalousek P, et al. Auxin flow mediated competition between
axillary buds to restore apical dominance. Scientific Reports. 2016;6.
doi:10.1038/srep35955
apa: Balla, J., Medved’Ová, Z., Kalousek, P., Matiješčuková, N., Friml, J., Reinöhl,
V., & Procházka, S. (2016). Auxin flow mediated competition between axillary
buds to restore apical dominance. Scientific Reports. Nature Publishing
Group. https://doi.org/10.1038/srep35955
chicago: Balla, Jozef, Zuzana Medved’Ová, Petr Kalousek, Natálie Matiješčuková,
Jiří Friml, Vilém Reinöhl, and Stanislav Procházka. “Auxin Flow Mediated Competition
between Axillary Buds to Restore Apical Dominance.” Scientific Reports.
Nature Publishing Group, 2016. https://doi.org/10.1038/srep35955.
ieee: J. Balla et al., “Auxin flow mediated competition between axillary
buds to restore apical dominance,” Scientific Reports, vol. 6. Nature Publishing
Group, 2016.
ista: Balla J, Medved’Ová Z, Kalousek P, Matiješčuková N, Friml J, Reinöhl V, Procházka
S. 2016. Auxin flow mediated competition between axillary buds to restore apical
dominance. Scientific Reports. 6, 35955.
mla: Balla, Jozef, et al. “Auxin Flow Mediated Competition between Axillary Buds
to Restore Apical Dominance.” Scientific Reports, vol. 6, 35955, Nature
Publishing Group, 2016, doi:10.1038/srep35955.
short: J. Balla, Z. Medved’Ová, P. Kalousek, N. Matiješčuková, J. Friml, V. Reinöhl,
S. Procházka, Scientific Reports 6 (2016).
date_created: 2018-12-11T11:50:24Z
date_published: 2016-11-08T00:00:00Z
date_updated: 2021-01-12T06:48:38Z
day: '08'
ddc:
- '581'
department:
- _id: JiFr
doi: 10.1038/srep35955
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:28Z
date_updated: 2018-12-12T10:09:28Z
file_id: '4752'
file_name: IST-2017-745-v1+1_srep35955.pdf
file_size: 1587544
relation: main_file
file_date_updated: 2018-12-12T10:09:28Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6211'
pubrep_id: '745'
quality_controlled: '1'
scopus_import: 1
status: public
title: Auxin flow mediated competition between axillary buds to restore apical dominance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2016'
...
---
_id: '1148'
abstract:
- lang: eng
text: Continuous-time Markov chain (CTMC) models have become a central tool for
understanding the dynamics of complex reaction networks and the importance of
stochasticity in the underlying biochemical processes. When such models are employed
to answer questions in applications, in order to ensure that the model provides
a sufficiently accurate representation of the real system, it is of vital importance
that the model parameters are inferred from real measured data. This, however,
is often a formidable task and all of the existing methods fail in one case or
the other, usually because the underlying CTMC model is high-dimensional and computationally
difficult to analyze. The parameter inference methods that tend to scale best
in the dimension of the CTMC are based on so-called moment closure approximations.
However, there exists a large number of different moment closure approximations
and it is typically hard to say a priori which of the approximations is the most
suitable for the inference procedure. Here, we propose a moment-based parameter
inference method that automatically chooses the most appropriate moment closure
method. Accordingly, contrary to existing methods, the user is not required to
be experienced in moment closure techniques. In addition to that, our method adaptively
changes the approximation during the parameter inference to ensure that always
the best approximation is used, even in cases where different approximations are
best in different regions of the parameter space. © 2016 Elsevier Ireland Ltd
acknowledgement: This work is based on the CMSB 2015 paper “Adaptive moment closure
for parameter inference of biochemical reaction networks” (Bogomolov et al., 2015).
The work was partly supported by the German Research Foundation (DFG) as part of
the Transregional Collaborative Research Center “Automatic Verification and Analysis
of Complex Systems” (SFB/TR 14 AVACS1), by the European Research Council (ERC) under
grant 267989 (QUAREM) and by the Austrian Science Fund (FWF) under grants S11402-N23
(RiSE) and Z211-N23 (Wittgenstein Award). J.R. acknowledges support from the People
Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme
(FP7/2007-2013) under REA grant agreement no. 291734.
author:
- first_name: Christian
full_name: Schilling, Christian
last_name: Schilling
- first_name: Sergiy
full_name: Bogomolov, Sergiy
id: 369D9A44-F248-11E8-B48F-1D18A9856A87
last_name: Bogomolov
orcid: 0000-0002-0686-0365
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Andreas
full_name: Podelski, Andreas
last_name: Podelski
- first_name: Jakob
full_name: Ruess, Jakob
id: 4A245D00-F248-11E8-B48F-1D18A9856A87
last_name: Ruess
orcid: 0000-0003-1615-3282
citation:
ama: Schilling C, Bogomolov S, Henzinger TA, Podelski A, Ruess J. Adaptive moment
closure for parameter inference of biochemical reaction networks. Biosystems.
2016;149:15-25. doi:10.1016/j.biosystems.2016.07.005
apa: Schilling, C., Bogomolov, S., Henzinger, T. A., Podelski, A., & Ruess,
J. (2016). Adaptive moment closure for parameter inference of biochemical reaction
networks. Biosystems. Elsevier. https://doi.org/10.1016/j.biosystems.2016.07.005
chicago: Schilling, Christian, Sergiy Bogomolov, Thomas A Henzinger, Andreas Podelski,
and Jakob Ruess. “Adaptive Moment Closure for Parameter Inference of Biochemical
Reaction Networks.” Biosystems. Elsevier, 2016. https://doi.org/10.1016/j.biosystems.2016.07.005.
ieee: C. Schilling, S. Bogomolov, T. A. Henzinger, A. Podelski, and J. Ruess, “Adaptive
moment closure for parameter inference of biochemical reaction networks,” Biosystems,
vol. 149. Elsevier, pp. 15–25, 2016.
ista: Schilling C, Bogomolov S, Henzinger TA, Podelski A, Ruess J. 2016. Adaptive
moment closure for parameter inference of biochemical reaction networks. Biosystems.
149, 15–25.
mla: Schilling, Christian, et al. “Adaptive Moment Closure for Parameter Inference
of Biochemical Reaction Networks.” Biosystems, vol. 149, Elsevier, 2016,
pp. 15–25, doi:10.1016/j.biosystems.2016.07.005.
short: C. Schilling, S. Bogomolov, T.A. Henzinger, A. Podelski, J. Ruess, Biosystems
149 (2016) 15–25.
date_created: 2018-12-11T11:50:24Z
date_published: 2016-11-01T00:00:00Z
date_updated: 2023-02-23T10:08:46Z
day: '01'
department:
- _id: ToHe
- _id: GaTk
doi: 10.1016/j.biosystems.2016.07.005
ec_funded: 1
intvolume: ' 149'
language:
- iso: eng
month: '11'
oa_version: None
page: 15 - 25
project:
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Biosystems
publication_status: published
publisher: Elsevier
publist_id: '6210'
quality_controlled: '1'
related_material:
record:
- id: '1658'
relation: earlier_version
status: public
scopus_import: 1
status: public
title: Adaptive moment closure for parameter inference of biochemical reaction networks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 149
year: '2016'
...
---
_id: '1149'
abstract:
- lang: eng
text: 'We study the usefulness of two most prominent publicly available rigorous
ODE integrators: one provided by the CAPD group (capd.ii.uj.edu.pl), the other
based on the COSY Infinity project (cosyinfinity.org). Both integrators are capable
of handling entire sets of initial conditions and provide tight rigorous outer
enclosures of the images under a time-T map. We conduct extensive benchmark computations
using the well-known Lorenz system, and compare the computation time against the
final accuracy achieved. We also discuss the effect of a few technical parameters,
such as the order of the numerical integration method, the value of T, and the
phase space resolution. We conclude that COSY may provide more precise results
due to its ability of avoiding the variable dependency problem. However, the overall
cost of computations conducted using CAPD is typically lower, especially when
intervals of parameters are involved. Moreover, access to COSY is limited (registration
required) and the rigorous ODE integrators are not publicly available, while CAPD
is an open source free software project. Therefore, we recommend the latter integrator
for this kind of computations. Nevertheless, proper choice of the various integration
parameters turns out to be of even greater importance than the choice of the integrator
itself. © 2016 IMACS. Published by Elsevier B.V. All rights reserved.'
acknowledgement: "MG was partially supported by FAPESP grants 2013/07460-7 and 2010/00875-9,
and by CNPq grants 305860/2013-5 and 306453/2009-6, Brazil. The work of HK was partially
supported by Grant-in-Aid for Scientific Research (Nos.24654022, 25287029), Ministry
of Education, Science, Technology, Culture and Sports, Japan. KM was supported by
NSF grants NSF-DMS-0835621, 0915019, 1125174, 1248071, and contracts from AFOSR
and DARPA. TM was supported by Grant-in-Aid for JSPS Fellows No. 245312. A part
of the research of TM and HK was also supported by JST, CREST.\r\n\r\nResearch conducted
by PP has received funding from Fundo Europeu de Desenvolvimento Regional (FEDER)
through COMPETE – Programa Operacional Factores de Competitividade (POFC) and from
the Portuguese national funds through Fundação para a Ciência e a Tecnologia (FCT)
in the framework of the research project FCOMP-01-0124-FEDER-010645 (Ref. FCT PTDC/MAT/098871/2008);
from the People Programme (Marie Curie Actions) of the European Union's Seventh
Framework Programme (FP7/2007-2013) under REA grant agreement No. 622033; and from
the same sources as HK.\r\n\r\nThe authors express their gratitude to the Department
of Mathematics of Kyoto University for making their server available for conducting
the computations described in the paper, and to the reviewers for helpful comments
that contributed towards increasing the quality of the paper."
author:
- first_name: Tomoyuki
full_name: Miyaji, Tomoyuki
last_name: Miyaji
- first_name: Pawel
full_name: Pilarczyk, Pawel
id: 3768D56A-F248-11E8-B48F-1D18A9856A87
last_name: Pilarczyk
- first_name: Marcio
full_name: Gameiro, Marcio
last_name: Gameiro
- first_name: Hiroshi
full_name: Kokubu, Hiroshi
last_name: Kokubu
- first_name: Konstantin
full_name: Mischaikow, Konstantin
last_name: Mischaikow
citation:
ama: Miyaji T, Pilarczyk P, Gameiro M, Kokubu H, Mischaikow K. A study of rigorous
ODE integrators for multi scale set oriented computations. Applied Numerical
Mathematics. 2016;107:34-47. doi:10.1016/j.apnum.2016.04.005
apa: Miyaji, T., Pilarczyk, P., Gameiro, M., Kokubu, H., & Mischaikow, K. (2016).
A study of rigorous ODE integrators for multi scale set oriented computations.
Applied Numerical Mathematics. Elsevier. https://doi.org/10.1016/j.apnum.2016.04.005
chicago: Miyaji, Tomoyuki, Pawel Pilarczyk, Marcio Gameiro, Hiroshi Kokubu, and
Konstantin Mischaikow. “A Study of Rigorous ODE Integrators for Multi Scale Set
Oriented Computations.” Applied Numerical Mathematics. Elsevier, 2016.
https://doi.org/10.1016/j.apnum.2016.04.005.
ieee: T. Miyaji, P. Pilarczyk, M. Gameiro, H. Kokubu, and K. Mischaikow, “A study
of rigorous ODE integrators for multi scale set oriented computations,” Applied
Numerical Mathematics, vol. 107. Elsevier, pp. 34–47, 2016.
ista: Miyaji T, Pilarczyk P, Gameiro M, Kokubu H, Mischaikow K. 2016. A study of
rigorous ODE integrators for multi scale set oriented computations. Applied Numerical
Mathematics. 107, 34–47.
mla: Miyaji, Tomoyuki, et al. “A Study of Rigorous ODE Integrators for Multi Scale
Set Oriented Computations.” Applied Numerical Mathematics, vol. 107, Elsevier,
2016, pp. 34–47, doi:10.1016/j.apnum.2016.04.005.
short: T. Miyaji, P. Pilarczyk, M. Gameiro, H. Kokubu, K. Mischaikow, Applied Numerical
Mathematics 107 (2016) 34–47.
date_created: 2018-12-11T11:50:25Z
date_published: 2016-09-01T00:00:00Z
date_updated: 2021-01-12T06:48:38Z
day: '01'
department:
- _id: HeEd
doi: 10.1016/j.apnum.2016.04.005
ec_funded: 1
intvolume: ' 107'
language:
- iso: eng
month: '09'
oa_version: None
page: 34 - 47
project:
- _id: 255F06BE-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '622033'
name: Persistent Homology - Images, Data and Maps
publication: Applied Numerical Mathematics
publication_status: published
publisher: Elsevier
publist_id: '6209'
quality_controlled: '1'
scopus_import: 1
status: public
title: A study of rigorous ODE integrators for multi scale set oriented computations
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 107
year: '2016'
...
---
_id: '1150'
abstract:
- lang: eng
text: When neutrophils infiltrate a site of inflammation, they have to stop at the
right place to exert their effector function. In this issue of Developmental Cell,
Wang et al. (2016) show that neutrophils sense reactive oxygen species via the
TRPM2 channel to arrest migration at their target site. © 2016 Elsevier Inc.
author:
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Renkawitz J, Sixt MK. A Radical Break Restraining Neutrophil Migration. Developmental
Cell. 2016;38(5):448-450. doi:10.1016/j.devcel.2016.08.017
apa: Renkawitz, J., & Sixt, M. K. (2016). A Radical Break Restraining Neutrophil
Migration. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2016.08.017
chicago: Renkawitz, Jörg, and Michael K Sixt. “A Radical Break Restraining Neutrophil
Migration.” Developmental Cell. Cell Press, 2016. https://doi.org/10.1016/j.devcel.2016.08.017.
ieee: J. Renkawitz and M. K. Sixt, “A Radical Break Restraining Neutrophil Migration,”
Developmental Cell, vol. 38, no. 5. Cell Press, pp. 448–450, 2016.
ista: Renkawitz J, Sixt MK. 2016. A Radical Break Restraining Neutrophil Migration.
Developmental Cell. 38(5), 448–450.
mla: Renkawitz, Jörg, and Michael K. Sixt. “A Radical Break Restraining Neutrophil
Migration.” Developmental Cell, vol. 38, no. 5, Cell Press, 2016, pp. 448–50,
doi:10.1016/j.devcel.2016.08.017.
short: J. Renkawitz, M.K. Sixt, Developmental Cell 38 (2016) 448–450.
date_created: 2018-12-11T11:50:25Z
date_published: 2016-09-12T00:00:00Z
date_updated: 2021-01-12T06:48:39Z
day: '12'
department:
- _id: MiSi
doi: 10.1016/j.devcel.2016.08.017
intvolume: ' 38'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 448 - 450
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '6208'
quality_controlled: '1'
scopus_import: 1
status: public
title: A Radical Break Restraining Neutrophil Migration
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2016'
...
---
_id: '1151'
abstract:
- lang: eng
text: Tissue patterning in multicellular organisms is the output of precise spatio–temporal
regulation of gene expression coupled with changes in hormone dynamics. In plants,
the hormone auxin regulates growth and development at every stage of a plant’s
life cycle. Auxin signaling occurs through binding of the auxin molecule to a
TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional
repressor proteins. These are subsequently ubiquitinated and degraded via the
26S proteasome, leading to derepression of auxin response factors (ARFs). How
auxin is able to elicit such a diverse range of developmental responses through
a single signaling module has not yet been resolved. Here we present an alternative
auxin-sensing mechanism in which the ARF ARF3/ETTIN controls gene expression through
interactions with process-specific transcription factors. This noncanonical hormonesensing
mechanism exhibits strong preference for the naturally occurring auxin indole
3-acetic acid (IAA) and is important for coordinating growth and patterning in
diverse developmental contexts such as gynoecium morphogenesis, lateral root emergence,
ovule development, and primary branch formation. Disrupting this IAA-sensing ability
induces morphological aberrations with consequences for plant fitness. Therefore,
our findings introduce a novel transcription factor-based mechanism of hormone
perception in plants. © 2016 Simonini et al.
acknowledgement: "We thank Norwich Research Park Bioimaging, Grant Calder, Roy\r\nDunford,
Caroline Smith, Paul Thomas, and Mark Youles for\r\ntechnical support; Charlie Scutt,
Alejandro Ferrando, and George\r\nLomonossoff for plasmids; Toshiro Ito for seeds;
Brendan Davies\r\nand Barry Causier for the REGIA library; and Mark Buttner,\r\nSimona
Masiero, Fabio Rossi, Doris Wagner, and Jun Xiao for\r\nhelp and material. We are
also grateful to Stefano Bencivenga,\r\nMarie Brüser, Friederike Jantzen, Lukasz
Langowski, Xinran Li,\r\nand Nicola Stacey for discussions and helpful comments
on the\r\nmanuscript. This work was supported by grants BB/M004112/1\r\nand BB/I017232/1
(Crop Improvement Research Club) to L.Ø.\r\nfrom the Biotechnological and Biological
Sciences Research\r\nCouncil, and Institute Strategic Programme grant (BB/J004553/\r\n1)
to the John Innes Centre. S.S., J.D., and L.Ø conceived the ex-\r\nperiments. "
author:
- first_name: Sara
full_name: Simonini, Sara
last_name: Simonini
- first_name: Joyita
full_name: Deb, Joyita
last_name: Deb
- first_name: Laila
full_name: Moubayidin, Laila
last_name: Moubayidin
- first_name: Pauline
full_name: Stephenson, Pauline
last_name: Stephenson
- first_name: Manoj
full_name: Valluru, Manoj
last_name: Valluru
- first_name: Alejandra
full_name: Freire Rios, Alejandra
last_name: Freire Rios
- first_name: Karim
full_name: Sorefan, Karim
last_name: Sorefan
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Lars
full_name: Östergaard, Lars
last_name: Östergaard
citation:
ama: Simonini S, Deb J, Moubayidin L, et al. A noncanonical auxin sensing mechanism
is required for organ morphogenesis in arabidopsis. Genes and Development.
2016;30(20):2286-2296. doi:10.1101/gad.285361.116
apa: Simonini, S., Deb, J., Moubayidin, L., Stephenson, P., Valluru, M., Freire
Rios, A., … Östergaard, L. (2016). A noncanonical auxin sensing mechanism is required
for organ morphogenesis in arabidopsis. Genes and Development. Cold Spring
Harbor Laboratory Press. https://doi.org/10.1101/gad.285361.116
chicago: Simonini, Sara, Joyita Deb, Laila Moubayidin, Pauline Stephenson, Manoj
Valluru, Alejandra Freire Rios, Karim Sorefan, Dolf Weijers, Jiří Friml, and Lars
Östergaard. “A Noncanonical Auxin Sensing Mechanism Is Required for Organ Morphogenesis
in Arabidopsis.” Genes and Development. Cold Spring Harbor Laboratory Press,
2016. https://doi.org/10.1101/gad.285361.116.
ieee: S. Simonini et al., “A noncanonical auxin sensing mechanism is required
for organ morphogenesis in arabidopsis,” Genes and Development, vol. 30,
no. 20. Cold Spring Harbor Laboratory Press, pp. 2286–2296, 2016.
ista: Simonini S, Deb J, Moubayidin L, Stephenson P, Valluru M, Freire Rios A, Sorefan
K, Weijers D, Friml J, Östergaard L. 2016. A noncanonical auxin sensing mechanism
is required for organ morphogenesis in arabidopsis. Genes and Development. 30(20),
2286–2296.
mla: Simonini, Sara, et al. “A Noncanonical Auxin Sensing Mechanism Is Required
for Organ Morphogenesis in Arabidopsis.” Genes and Development, vol. 30,
no. 20, Cold Spring Harbor Laboratory Press, 2016, pp. 2286–96, doi:10.1101/gad.285361.116.
short: S. Simonini, J. Deb, L. Moubayidin, P. Stephenson, M. Valluru, A. Freire
Rios, K. Sorefan, D. Weijers, J. Friml, L. Östergaard, Genes and Development 30
(2016) 2286–2296.
date_created: 2018-12-11T11:50:25Z
date_published: 2016-10-15T00:00:00Z
date_updated: 2021-01-12T06:48:39Z
day: '15'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.1101/gad.285361.116
external_id:
pmid:
- '27898393'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2019-01-25T09:32:55Z
date_updated: 2019-01-25T09:32:55Z
file_id: '5882'
file_name: 2016_GeneDev_Simonini.pdf
file_size: 1419263
relation: main_file
success: 1
file_date_updated: 2019-01-25T09:32:55Z
has_accepted_license: '1'
intvolume: ' 30'
issue: '20'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 2286 - 2296
pmid: 1
publication: Genes and Development
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '6207'
quality_controlled: '1'
scopus_import: 1
status: public
title: A noncanonical auxin sensing mechanism is required for organ morphogenesis
in arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2016'
...
---
_id: '1153'
abstract:
- lang: eng
text: Differential cell growth enables flexible organ bending in the presence of
environmental signals such as light or gravity. A prominent example of the developmental
processes based on differential cell growth is the formation of the apical hook
that protects the fragile shoot apical meristem when it breaks through the soil
during germination. Here, we combined in silico and in vivo approaches to identify
a minimal mechanism producing auxin gradient-guided differential growth during
the establishment of the apical hook in the model plant Arabidopsis thaliana.
Computer simulation models based on experimental data demonstrate that asymmetric
expression of the PIN-FORMED auxin efflux carrier at the concave (inner) versus
convex (outer) side of the hook suffices to establish an auxin maximum in the
epidermis at the concave side of the apical hook. Furthermore, we propose a mechanism
that translates this maximum into differential growth, and thus curvature, of
the apical hook. Through a combination of experimental and in silico computational
approaches, we have identified the individual contributions of differential cell
elongation and proliferation to defining the apical hook and reveal the role of
auxin-ethylene crosstalk in balancing these two processes. © 2016 American Society
of Plant Biologists. All rights reserved.
acknowledgement: "We thank Martine De Cock and Annick Bleys for help in preparing
the manuscript, Daniel Van Damme for sharing material and stimulating discussion,
and Rudiger Simon for support during revision of the manuscript.\r\nThis work was
supported by grants from the European Research Council (StartingIndependentResearchGrantERC-2007-Stg-207362-HCPO)and
the Czech Science Foundation (GACR CZ.1.07/2.3.00/20.0043) to E.B.\r\nand Natural
Sciences and Engineering Research Council of Canada Discovery Grant 2014-05325 to
P.P. K.W. acknowledges funding from a Human Frontier Science Program Long-Term Fellowship
(LT-000209-2014)."
author:
- first_name: Petra
full_name: Žádníková, Petra
last_name: Žádníková
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Anas
full_name: Abuzeineh, Anas
last_name: Abuzeineh
- first_name: Marçal
full_name: Gallemí, Marçal
last_name: Gallemí
- first_name: Dominique
full_name: Van Der Straeten, Dominique
last_name: Van Der Straeten
- first_name: Richard
full_name: Smith, Richard
last_name: Smith
- first_name: Dirk
full_name: Inze, Dirk
last_name: Inze
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Przemysław
full_name: Prusinkiewicz, Przemysław
last_name: Prusinkiewicz
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Žádníková P, Wabnik KT, Abuzeineh A, et al. A model of differential growth
guided apical hook formation in plants. Plant Cell. 2016;28(10):2464-2477.
doi:10.1105/tpc.15.00569
apa: Žádníková, P., Wabnik, K. T., Abuzeineh, A., Gallemí, M., Van Der Straeten,
D., Smith, R., … Benková, E. (2016). A model of differential growth guided apical
hook formation in plants. Plant Cell. American Society of Plant Biologists.
https://doi.org/10.1105/tpc.15.00569
chicago: Žádníková, Petra, Krzysztof T Wabnik, Anas Abuzeineh, Marçal Gallemí, Dominique
Van Der Straeten, Richard Smith, Dirk Inze, Jiří Friml, Przemysław Prusinkiewicz,
and Eva Benková. “A Model of Differential Growth Guided Apical Hook Formation
in Plants.” Plant Cell. American Society of Plant Biologists, 2016. https://doi.org/10.1105/tpc.15.00569.
ieee: P. Žádníková et al., “A model of differential growth guided apical
hook formation in plants,” Plant Cell, vol. 28, no. 10. American Society
of Plant Biologists, pp. 2464–2477, 2016.
ista: Žádníková P, Wabnik KT, Abuzeineh A, Gallemí M, Van Der Straeten D, Smith
R, Inze D, Friml J, Prusinkiewicz P, Benková E. 2016. A model of differential
growth guided apical hook formation in plants. Plant Cell. 28(10), 2464–2477.
mla: Žádníková, Petra, et al. “A Model of Differential Growth Guided Apical Hook
Formation in Plants.” Plant Cell, vol. 28, no. 10, American Society of
Plant Biologists, 2016, pp. 2464–77, doi:10.1105/tpc.15.00569.
short: P. Žádníková, K.T. Wabnik, A. Abuzeineh, M. Gallemí, D. Van Der Straeten,
R. Smith, D. Inze, J. Friml, P. Prusinkiewicz, E. Benková, Plant Cell 28 (2016)
2464–2477.
date_created: 2018-12-11T11:50:26Z
date_published: 2016-10-01T00:00:00Z
date_updated: 2021-01-12T06:48:40Z
day: '01'
department:
- _id: EvBe
- _id: JiFr
doi: 10.1105/tpc.15.00569
ec_funded: 1
intvolume: ' 28'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134968/
month: '10'
oa: 1
oa_version: Submitted Version
page: 2464 - 2477
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '207362'
name: Hormonal cross-talk in plant organogenesis
publication: Plant Cell
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '6205'
quality_controlled: '1'
scopus_import: 1
status: public
title: A model of differential growth guided apical hook formation in plants
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2016'
...
---
_id: '1154'
abstract:
- lang: eng
text: "Cellular locomotion is a central hallmark of eukaryotic life. It is governed
by cell-extrinsic molecular factors, which can either emerge in the soluble phase
or as immobilized, often adhesive ligands. To encode for direction, every cue
must be present as a spatial or temporal gradient. Here, we developed a microfluidic
chamber that allows measurement of cell migration in combined response to surface
immobilized and soluble molecular gradients. As a proof of principle we study
the response of dendritic cells to their major guidance cues, chemokines. The
majority of data on chemokine gradient sensing is based on in vitro studies employing
soluble gradients. Despite evidence suggesting that in vivo chemokines are often
immobilized to sugar residues, limited information is available how cells respond
to immobilized chemokines. We tracked migration of dendritic cells towards immobilized
gradients of the chemokine CCL21 and varying superimposed soluble gradients of
CCL19. Differential migratory patterns illustrate the potential of our setup to
quantitatively study the competitive response to both types of gradients. Beyond
chemokines our approach is broadly applicable to alternative systems of chemo-
and haptotaxis such as cells migrating along gradients of adhesion receptor ligands
vs. any soluble cue. \r\n"
acknowledgement: 'This work was supported by the Swiss National Science Foundation
(Ambizione fellowship; PZ00P3-154733 to M.M.), the Swiss Multiple Sclerosis Society
(research support to M.M.), a fellowship from the Boehringer Ingelheim Fonds (BIF)
to J.S., the European Research Council (grant ERC GA 281556) and a START award from
the Austrian Science Foundation (FWF) to M.S. #BioimagingFacility'
article_number: '36440'
author:
- first_name: Jan
full_name: Schwarz, Jan
id: 346C1EC6-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Veronika
full_name: Bierbaum, Veronika
id: 3FD04378-F248-11E8-B48F-1D18A9856A87
last_name: Bierbaum
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Tino
full_name: Frank, Tino
last_name: Frank
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Savaş
full_name: Tay, Savaş
last_name: Tay
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Matthias
full_name: Mehling, Matthias
id: 3C23B994-F248-11E8-B48F-1D18A9856A87
last_name: Mehling
orcid: 0000-0001-8599-1226
citation:
ama: Schwarz J, Bierbaum V, Merrin J, et al. A microfluidic device for measuring
cell migration towards substrate bound and soluble chemokine gradients. Scientific
Reports. 2016;6. doi:10.1038/srep36440
apa: Schwarz, J., Bierbaum, V., Merrin, J., Frank, T., Hauschild, R., Bollenbach,
M. T., … Mehling, M. (2016). A microfluidic device for measuring cell migration
towards substrate bound and soluble chemokine gradients. Scientific Reports.
Nature Publishing Group. https://doi.org/10.1038/srep36440
chicago: Schwarz, Jan, Veronika Bierbaum, Jack Merrin, Tino Frank, Robert Hauschild,
Mark Tobias Bollenbach, Savaş Tay, Michael K Sixt, and Matthias Mehling. “A Microfluidic
Device for Measuring Cell Migration towards Substrate Bound and Soluble Chemokine
Gradients.” Scientific Reports. Nature Publishing Group, 2016. https://doi.org/10.1038/srep36440.
ieee: J. Schwarz et al., “A microfluidic device for measuring cell migration
towards substrate bound and soluble chemokine gradients,” Scientific Reports,
vol. 6. Nature Publishing Group, 2016.
ista: Schwarz J, Bierbaum V, Merrin J, Frank T, Hauschild R, Bollenbach MT, Tay
S, Sixt MK, Mehling M. 2016. A microfluidic device for measuring cell migration
towards substrate bound and soluble chemokine gradients. Scientific Reports. 6,
36440.
mla: Schwarz, Jan, et al. “A Microfluidic Device for Measuring Cell Migration towards
Substrate Bound and Soluble Chemokine Gradients.” Scientific Reports, vol.
6, 36440, Nature Publishing Group, 2016, doi:10.1038/srep36440.
short: J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach,
S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).
date_created: 2018-12-11T11:50:27Z
date_published: 2016-11-07T00:00:00Z
date_updated: 2021-01-12T06:48:41Z
day: '07'
ddc:
- '579'
department:
- _id: MiSi
- _id: NanoFab
- _id: Bio
- _id: ToBo
doi: 10.1038/srep36440
ec_funded: 1
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:32Z
date_updated: 2018-12-12T10:09:32Z
file_id: '4756'
file_name: IST-2017-744-v1+1_srep36440.pdf
file_size: 2353456
relation: main_file
file_date_updated: 2018-12-12T10:09:32Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and transduction of leukocytes (FWF)
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6204'
pubrep_id: '744'
quality_controlled: '1'
scopus_import: 1
status: public
title: A microfluidic device for measuring cell migration towards substrate bound
and soluble chemokine gradients
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2016'
...
---
_id: '1156'
abstract:
- lang: eng
text: Let k, n, and r be positive integers with k < n and r≤⌊nk⌋. We determine
the facets of the r-stable n, k-hypersimplex. As a result, it turns out that the
r-stable n, k-hypersimplex has exactly 2n facets for every r<⌊nk⌋. We then
utilize the equations of the facets to study when the r-stable hypersimplex is
Gorenstein. For every k > 0 we identify an infinite collection of Gorenstein
r-stable hypersimplices, consequently expanding the collection of r-stable hypersimplices
known to have unimodal Ehrhart δ-vectors.
acknowledgement: "Liam Solus was supported by a 2014 National Science Foundation/Japan
Society for the Promotion of Science East Asia and Pacific Summer Institute Fellowship.
\nOpen access funding provided by IST Austria."
author:
- first_name: Takayugi
full_name: Hibi, Takayugi
last_name: Hibi
- first_name: Liam T
full_name: Liam Solus
id: 2AADA620-F248-11E8-B48F-1D18A9856A87
last_name: Solus
citation:
ama: Hibi T, Solus LT. Facets of the r-stable (n, k)-hypersimplex. Annals of
Combinatorics. 2016;20(4):815-829. doi:10.1007/s00026-016-0325-x
apa: Hibi, T., & Solus, L. T. (2016). Facets of the r-stable (n, k)-hypersimplex.
Annals of Combinatorics. Springer. https://doi.org/10.1007/s00026-016-0325-x
chicago: Hibi, Takayugi, and Liam T Solus. “Facets of the R-Stable (n, k)-Hypersimplex.”
Annals of Combinatorics. Springer, 2016. https://doi.org/10.1007/s00026-016-0325-x.
ieee: T. Hibi and L. T. Solus, “Facets of the r-stable (n, k)-hypersimplex,” Annals
of Combinatorics, vol. 20, no. 4. Springer, pp. 815–829, 2016.
ista: Hibi T, Solus LT. 2016. Facets of the r-stable (n, k)-hypersimplex. Annals
of Combinatorics. 20(4), 815–829.
mla: Hibi, Takayugi, and Liam T. Solus. “Facets of the R-Stable (n, k)-Hypersimplex.”
Annals of Combinatorics, vol. 20, no. 4, Springer, 2016, pp. 815–29, doi:10.1007/s00026-016-0325-x.
short: T. Hibi, L.T. Solus, Annals of Combinatorics 20 (2016) 815–829.
date_created: 2018-12-11T11:50:27Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2021-01-12T06:48:43Z
day: '01'
doi: 10.1007/s00026-016-0325-x
extern: 1
intvolume: ' 20'
issue: '4'
month: '12'
page: 815 - 829
publication: Annals of Combinatorics
publication_status: published
publisher: Springer
publist_id: '6202'
quality_controlled: 0
status: public
title: Facets of the r-stable (n, k)-hypersimplex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 20
year: '2016'
...
---
_id: '1157'
abstract:
- lang: eng
text: We consider sample covariance matrices of the form Q = ( σ1/2X)(σ1/2X)∗, where
the sample X is an M ×N random matrix whose entries are real independent random
variables with variance 1/N and whereσ is an M × M positive-definite deterministic
matrix. We analyze the asymptotic fluctuations of the largest rescaled eigenvalue
of Q when both M and N tend to infinity with N/M →d ϵ (0,∞). For a large class
of populations σ in the sub-critical regime, we show that the distribution of
the largest rescaled eigenvalue of Q is given by the type-1 Tracy-Widom distribution
under the additional assumptions that (1) either the entries of X are i.i.d. Gaussians
or (2) that σ is diagonal and that the entries of X have a sub-exponential decay.
acknowledgement: "We thank Horng-Tzer Yau for numerous discussions and remarks. We
are grateful to Ben Adlam, Jinho Baik, Zhigang Bao, Paul Bourgade, László Erd ̋os,
Iain Johnstone and Antti Knowles for comments. We are also grate-\r\nful to the
anonymous referee for carefully reading our manuscript and suggesting several improvements."
author:
- first_name: Ji
full_name: Lee, Ji
last_name: Lee
- first_name: Kevin
full_name: Schnelli, Kevin
id: 434AD0AE-F248-11E8-B48F-1D18A9856A87
last_name: Schnelli
orcid: 0000-0003-0954-3231
citation:
ama: Lee J, Schnelli K. Tracy-widom distribution for the largest eigenvalue of real
sample covariance matrices with general population. Annals of Applied Probability.
2016;26(6):3786-3839. doi:10.1214/16-AAP1193
apa: Lee, J., & Schnelli, K. (2016). Tracy-widom distribution for the largest
eigenvalue of real sample covariance matrices with general population. Annals
of Applied Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/16-AAP1193
chicago: Lee, Ji, and Kevin Schnelli. “Tracy-Widom Distribution for the Largest
Eigenvalue of Real Sample Covariance Matrices with General Population.” Annals
of Applied Probability. Institute of Mathematical Statistics, 2016. https://doi.org/10.1214/16-AAP1193.
ieee: J. Lee and K. Schnelli, “Tracy-widom distribution for the largest eigenvalue
of real sample covariance matrices with general population,” Annals of Applied
Probability, vol. 26, no. 6. Institute of Mathematical Statistics, pp. 3786–3839,
2016.
ista: Lee J, Schnelli K. 2016. Tracy-widom distribution for the largest eigenvalue
of real sample covariance matrices with general population. Annals of Applied
Probability. 26(6), 3786–3839.
mla: Lee, Ji, and Kevin Schnelli. “Tracy-Widom Distribution for the Largest Eigenvalue
of Real Sample Covariance Matrices with General Population.” Annals of Applied
Probability, vol. 26, no. 6, Institute of Mathematical Statistics, 2016, pp.
3786–839, doi:10.1214/16-AAP1193.
short: J. Lee, K. Schnelli, Annals of Applied Probability 26 (2016) 3786–3839.
date_created: 2018-12-11T11:50:27Z
date_published: 2016-12-15T00:00:00Z
date_updated: 2021-01-12T06:48:43Z
day: '15'
department:
- _id: LaEr
doi: 10.1214/16-AAP1193
ec_funded: 1
intvolume: ' 26'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1409.4979
month: '12'
oa: 1
oa_version: Preprint
page: 3786 - 3839
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
publication: Annals of Applied Probability
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '6201'
quality_controlled: '1'
scopus_import: 1
status: public
title: Tracy-widom distribution for the largest eigenvalue of real sample covariance
matrices with general population
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2016'
...
---
_id: '11574'
abstract:
- lang: eng
text: We present new results from the widest narrow-band survey search for Lyα emitters
at z = 5.7, just after reionization. We survey a total of 7 deg2 spread over the
COSMOS, UDS and SA22 fields. We find over 11 000 line emitters, out of which 514
are robust Lyα candidates at z = 5.7 within a volume of 6.3 × 106 Mpc3. Our Lyα
emitters span a wide range in Lyα luminosities, from faint to bright (LLyα ∼ 1042.5–44
erg s−1) and rest-frame equivalent widths (EW0 ∼ 25–1000 Å) in a single, homogeneous
data set. By combining all our fields, we find that the faint end slope of the
z = 5.7 Lyα luminosity function is very steep, with α=−2.3+0.4−0.3. We also present
an updated z = 6.6 Lyα luminosity function, based on comparable volumes and obtained
with the same methods, which we directly compare with that at z = 5.7. We find
a significant decline of the number density of faint Lyα emitters from z = 5.7
to 6.6 (by 0.5 ± 0.1 dex), but no evolution at the bright end/no evolution in
L*. Faint Lyα emitters at z = 6.6 show much more extended haloes than those at
z = 5.7, suggesting that neutral Hydrogen plays an important role, increasing
the scattering and leading to observations missing faint Lyα emission within the
epoch of reionization. Altogether, our results suggest that we are observing patchy
reionization which happens first around the brightest Lyα emitters, allowing the
number densities of those sources to remain unaffected by the increase of neutral
Hydrogen fraction from z ∼ 5 to 7.
acknowledgement: 'We thank the anonymous referee for useful and constructive comments
and suggestions which greatly improved the quality and clarity of our work. The
authors acknowledge financial support from the Netherlands Organisation for Scientific
research (NWO) through a Veni fellowship. SS and DS acknowledge funding from FCT
through an FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010).
SS also acknowledges support from FCT through the research grants UID/FIS/04434/2013
and PTDC/FIS-AST/2194/2012. JM acknowledges a Huygens PhD fellowship from Leiden
University. Based on observations with the Subaru Telescope (Program IDs: S05B-027,
S06A-025, S06B-010, S07A-013, S07B-008, S08B-008, S09A-017, S14A-086). Based on
observations made with ESO Telescopes at the La Silla Paranal Observatory under
programme ID 294.A-5018. Based on observations obtained with MegaPrime/Megacam,
a joint project of CFHT and CEA/IRFU, at the Canada–France–Hawaii Telescope (CFHT)
which is operated by the National Research Council (NRC) of Canada, the Institut
National des Science de l’Univers of the Centre National de la Recherche Scientifique
(CNRS) of France, and the University of Hawaii. This work is based in part on data
products produced at TERAPIX available at the Canadian Astronomy Data Centre as
part of the Canada–France–Hawaii Telescope Legacy Survey, a collaborative project
of NRC and CNRS. Based on data products from observations made with ESO Telescopes
at the La Silla Paranal Observatory under ESO programme ID 179.A-2005 and on data
products produced by TERAPIX and the Cambridge Astronomy Survey Unit on behalf of
the UltraVISTA consortium. We are grateful to the CFHTLS, COSMOS-UltraVISTA, UKIDSS,
SXDF and COSMOS survey teams. Without these legacy surveys, this research would
have been impossible. The authors wish to recognize and acknowledge the very significant
cultural role and reverence that the summit of Mauna Kea has always had within the
indigenous Hawaiian community. We are most fortunate to have the opportunity to
conduct and explore observations from this mountain. Finally, the authors acknowledge
the unique value of the publicly available programming language PYTHON, including
the NUMPY, PYFITS, MATPLOTLIB, SCIPY and ASTROPY (Astropy Collaboration et al.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sérgio
full_name: Santos, Sérgio
last_name: Santos
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: 'Santos S, Sobral D, Matthee JJ. The Lyα luminosity function at z= 5.7–6.6
and the steep drop of the faint end: Implications for reionization. Monthly
Notices of the Royal Astronomical Society. 2016;463(2):1678-1691. doi:10.1093/mnras/stw2076'
apa: 'Santos, S., Sobral, D., & Matthee, J. J. (2016). The Lyα luminosity function
at z= 5.7–6.6 and the steep drop of the faint end: Implications for reionization.
Monthly Notices of the Royal Astronomical Society. Oxford University Press.
https://doi.org/10.1093/mnras/stw2076'
chicago: 'Santos, Sérgio, David Sobral, and Jorryt J Matthee. “The Lyα Luminosity
Function at Z= 5.7–6.6 and the Steep Drop of the Faint End: Implications for Reionization.”
Monthly Notices of the Royal Astronomical Society. Oxford University Press,
2016. https://doi.org/10.1093/mnras/stw2076.'
ieee: 'S. Santos, D. Sobral, and J. J. Matthee, “The Lyα luminosity function at
z= 5.7–6.6 and the steep drop of the faint end: Implications for reionization,”
Monthly Notices of the Royal Astronomical Society, vol. 463, no. 2. Oxford
University Press, pp. 1678–1691, 2016.'
ista: 'Santos S, Sobral D, Matthee JJ. 2016. The Lyα luminosity function at z= 5.7–6.6
and the steep drop of the faint end: Implications for reionization. Monthly Notices
of the Royal Astronomical Society. 463(2), 1678–1691.'
mla: 'Santos, Sérgio, et al. “The Lyα Luminosity Function at Z= 5.7–6.6 and the
Steep Drop of the Faint End: Implications for Reionization.” Monthly Notices
of the Royal Astronomical Society, vol. 463, no. 2, Oxford University Press,
2016, pp. 1678–91, doi:10.1093/mnras/stw2076.'
short: S. Santos, D. Sobral, J.J. Matthee, Monthly Notices of the Royal Astronomical
Society 463 (2016) 1678–1691.
date_created: 2022-07-13T10:08:20Z
date_published: 2016-12-01T00:00:00Z
date_updated: 2022-08-19T08:09:54Z
day: '01'
doi: 10.1093/mnras/stw2076
extern: '1'
external_id:
arxiv:
- '1606.07435'
intvolume: ' 463'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: high-redshift'
- 'galaxies: luminosity function'
- mass function
- 'cosmology: observations'
- dark ages
- reionization
- first stars
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1606.07435
month: '12'
oa: 1
oa_version: Preprint
page: 1678-1691
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The Lyα luminosity function at z= 5.7–6.6 and the steep drop of the faint
end: Implications for reionization'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 463
year: '2016'
...
---
_id: '11575'
abstract:
- lang: eng
text: We investigate correlations between different physical properties of star-forming
galaxies in the ‘Evolution and Assembly of GaLaxies and their Environments’ (EAGLE)
cosmological hydrodynamical simulation suite over the redshift range 0 ≤ z ≤ 4.5.
A principal component analysis reveals that neutral gas fraction (fgas,neutral),
stellar mass (Mstellar) and star formation rate (SFR) account for most of the
variance seen in the population, with galaxies tracing a two-dimensional, nearly
flat, surface in the three-dimensional space of fgas, neutral–Mstellar–SFR with
little scatter. The location of this plane varies little with redshift, whereas
galaxies themselves move along the plane as their fgas, neutral and SFR drop with
redshift. The positions of galaxies along the plane are highly correlated with
gas metallicity. The metallicity can therefore be robustly predicted from fgas,
neutral, or from the Mstellar and SFR. We argue that the appearance of this ‘Fundamental
Plane of star formation’ is a consequence of self-regulation, with the plane's
curvature set by the dependence of the SFR on gas density and metallicity. We
analyse a large compilation of observations spanning the redshift range 0 ≲ z
≲ 3, and find that such a plane is also present in the data. The properties of
the observed Fundamental Plane of star formation are in good agreement with EAGLE's
predictions.
acknowledgement: We thank Luca Cortese, Matt Bothwell, Paola Santini and Tim Davis
for providing observational data sets, and Aaron Robotham, Luca Cortese and Barbara
Catinella for useful discussions. CdPL is funded by a Discovery Early Career Researcher
Award (DE150100618). CdPL also thanks the MERAC Foundation for a Postdoctoral Research
Award. This work used the DiRAC Data Centric system at Durham University, operated
by the Institute for Computational Cosmology on behalf of the STFC DiRAC HPC Facility
(www.dirac.ac.uk). This equipment was funded by BIS National E-infrastructure capital
grant ST/K00042X/1, STFC capital grant ST/H008519/1, and STFC DiRAC Operations grant
ST/K003267/1 and Durham University. DiRAC is part of the National E-Infrastructure.
Support was also received via the Interuniversity Attraction Poles Programme initiated
by the Belgian Science Policy Office ([AP P7/08 CHARM]), the National Science Foundation
under grant no. NSF PHY11-25915, and the UK Science and Technology Facilities Council
(grant numbers ST/F001166/1 and ST/I000976/1) via rolling and consolidating grants
awarded to the ICC. The research was supported in part by the European Research
Council under the European Union‘s Seventh Framework Programme (FP7/2007-2013)/ERC
grant agreement 278594-GasAroundGalaxies.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Claudia del P.
full_name: Lagos, Claudia del P.
last_name: Lagos
- first_name: Tom
full_name: Theuns, Tom
last_name: Theuns
- first_name: Joop
full_name: Schaye, Joop
last_name: Schaye
- first_name: Michelle
full_name: Furlong, Michelle
last_name: Furlong
- first_name: Richard G.
full_name: Bower, Richard G.
last_name: Bower
- first_name: Matthieu
full_name: Schaller, Matthieu
last_name: Schaller
- first_name: Robert A.
full_name: Crain, Robert A.
last_name: Crain
- first_name: James W.
full_name: Trayford, James W.
last_name: Trayford
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: Lagos C del P, Theuns T, Schaye J, et al. The Fundamental Plane of star formation
in galaxies revealed by the EAGLE hydrodynamical simulations. Monthly Notices
of the Royal Astronomical Society. 2016;459(3):2632-2650. doi:10.1093/mnras/stw717
apa: Lagos, C. del P., Theuns, T., Schaye, J., Furlong, M., Bower, R. G., Schaller,
M., … Matthee, J. J. (2016). The Fundamental Plane of star formation in galaxies
revealed by the EAGLE hydrodynamical simulations. Monthly Notices of the Royal
Astronomical Society. Oxford University Press. https://doi.org/10.1093/mnras/stw717
chicago: Lagos, Claudia del P., Tom Theuns, Joop Schaye, Michelle Furlong, Richard
G. Bower, Matthieu Schaller, Robert A. Crain, James W. Trayford, and Jorryt J
Matthee. “The Fundamental Plane of Star Formation in Galaxies Revealed by the
EAGLE Hydrodynamical Simulations.” Monthly Notices of the Royal Astronomical
Society. Oxford University Press, 2016. https://doi.org/10.1093/mnras/stw717.
ieee: C. del P. Lagos et al., “The Fundamental Plane of star formation in
galaxies revealed by the EAGLE hydrodynamical simulations,” Monthly Notices
of the Royal Astronomical Society, vol. 459, no. 3. Oxford University Press,
pp. 2632–2650, 2016.
ista: Lagos C del P, Theuns T, Schaye J, Furlong M, Bower RG, Schaller M, Crain
RA, Trayford JW, Matthee JJ. 2016. The Fundamental Plane of star formation in
galaxies revealed by the EAGLE hydrodynamical simulations. Monthly Notices of
the Royal Astronomical Society. 459(3), 2632–2650.
mla: Lagos, Claudia del P., et al. “The Fundamental Plane of Star Formation in Galaxies
Revealed by the EAGLE Hydrodynamical Simulations.” Monthly Notices of the Royal
Astronomical Society, vol. 459, no. 3, Oxford University Press, 2016, pp.
2632–50, doi:10.1093/mnras/stw717.
short: C. del P. Lagos, T. Theuns, J. Schaye, M. Furlong, R.G. Bower, M. Schaller,
R.A. Crain, J.W. Trayford, J.J. Matthee, Monthly Notices of the Royal Astronomical
Society 459 (2016) 2632–2650.
date_created: 2022-07-13T10:21:24Z
date_published: 2016-07-01T00:00:00Z
date_updated: 2022-08-19T08:12:07Z
day: '01'
doi: 10.1093/mnras/stw717
extern: '1'
external_id:
arxiv:
- '1510.08067'
intvolume: ' 459'
issue: '3'
keyword:
- Space and Planetary Science
- 'Astronomy and Astrophysics stars: formation'
- 'ISM: evolution'
- 'galaxies: evolution'
- 'galaxies: formation'
- 'galaxies: ISM'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1510.08067
month: '07'
oa: 1
oa_version: Preprint
page: 2632-2650
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Fundamental Plane of star formation in galaxies revealed by the EAGLE hydrodynamical
simulations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 459
year: '2016'
...
---
_id: '11576'
abstract:
- lang: eng
text: We use new near-infrared spectroscopic observations to investigate the nature
and evolution of the most luminous Hα emitters at z ∼ 0.8–2.23, which evolve strongly
in number density over this period, and compare them to more typical Hα emitters.
We study 59 luminous Hα emitters with LHα > L∗Hα, roughly equally split per redshift
slice at z ∼ 0.8, 1.47 and 2.23 from the HiZELS and CF-HiZELS surveys. We find
that, overall, 30 ± 8 per cent are active galactic nuclei [AGNs; 80 ± 30 per cent
of these AGNs are broad-line AGNs, BL-AGNs], and we find little to no evolution
in the AGN fraction with redshift, within the errors. However, the AGN fraction
increases strongly with Hα luminosity and correlates best with LHα/L∗Hα(z). While
LHα ≤ L∗Hα(z) Hα emitters are largely dominated by star-forming galaxies (>80
per cent), the most luminous Hα emitters (LHα>10L∗Hα(z)) at any cosmic time
are essentially all BL-AGN. Using our AGN-decontaminated sample of luminous star-forming
galaxies, and integrating down to a fixed Hα luminosity, we find a factor of ∼1300
evolution in the star formation rate density from z = 0 to 2.23. This is much
stronger than the evolution from typical Hα star-forming galaxies and in line
with the evolution seen for constant luminosity cuts used to select ‘ultraluminous’
infrared galaxies and/or sub-millimetre galaxies. By taking into account the evolution
in the typical Hα luminosity, we show that the most strongly star-forming Hα-selected
galaxies at any epoch (LHα>L∗Hα(z)) contribute the same fractional amount of
≈15 per cent to the total star formation rate density, at least up to z = 2.23.
acknowledgement: "The authors would like to thank the anonymous reviewer for the many
helpful comments and suggestions which greatly improved the clarity and quality
of this work. DS and SAK acknowledge financial support from the Netherlands Organisation
for Scientific research (NWO) through a Veni fellowship. DS also acknowledges funding
from FCT through an FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010)
and from FCT grant PEst-OE/FIS/UI2751/2014. Part of this project was undertaken
during the inaugural Leiden/ESA Astrophysics Program for Summer Students (LEAPS).
IRS acknowledges support from STFC (ST/L00075X/1), the ERC Advanced Investigator
programme DUSTYGAL 321334 and a Royal Society/Wolfson merit award. CH acknowledges
support from STFC. Based on observations made with ESO Telescopes at the La Silla
Paranal Observatory under programme ID 087.A-0337 and ID 089.A-0965. Also based
on data from the Telescopio Nazionale Galileo, with time awarded through OPTICON
programmes 2011A/026 and 2012A020 and the William Herschel Telescope under programme
W12BN007. The William Herschel Telescope is operated on the island of La Palma by
the Isaac Newton Group in the Spanish\r\nObservatorio del Roque de los Muchachos
of the Instituto de Astrofisica de Canarias. The authors wish to thank all the help
given by the telescope staff from all the observatories used in this study: ESO
staff in La Silla, and the TNG and WHT staff in La Palma. This publication makes
use of data products from the Two Micron All-Sky Survey, which is a joint project
of the University of Massachusetts and the Infrared Processing and Analysis Center/California
Institute of Technology, funded by the National Aeronautics and Space Administration
and the National Science Foundation."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Saul A.
full_name: Kohn, Saul A.
last_name: Kohn
- first_name: Philip N.
full_name: Best, Philip N.
last_name: Best
- first_name: Ian
full_name: Smail, Ian
last_name: Smail
- first_name: Chris M.
full_name: Harrison, Chris M.
last_name: Harrison
- first_name: John
full_name: Stott, John
last_name: Stott
- first_name: João
full_name: Calhau, João
last_name: Calhau
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
citation:
ama: 'Sobral D, Kohn SA, Best PN, et al. The most luminous H α emitters at z ∼ 0.8–2.23
from HiZELS: Evolution of AGN and star-forming galaxies. Monthly Notices of
the Royal Astronomical Society. 2016;457(2):1739-1752. doi:10.1093/mnras/stw022'
apa: 'Sobral, D., Kohn, S. A., Best, P. N., Smail, I., Harrison, C. M., Stott, J.,
… Matthee, J. J. (2016). The most luminous H α emitters at z ∼ 0.8–2.23 from HiZELS:
Evolution of AGN and star-forming galaxies. Monthly Notices of the Royal Astronomical
Society. Oxford University Press. https://doi.org/10.1093/mnras/stw022'
chicago: 'Sobral, David, Saul A. Kohn, Philip N. Best, Ian Smail, Chris M. Harrison,
John Stott, João Calhau, and Jorryt J Matthee. “The Most Luminous H α Emitters
at z ∼ 0.8–2.23 from HiZELS: Evolution of AGN and Star-Forming Galaxies.” Monthly
Notices of the Royal Astronomical Society. Oxford University Press, 2016.
https://doi.org/10.1093/mnras/stw022.'
ieee: 'D. Sobral et al., “The most luminous H α emitters at z ∼ 0.8–2.23
from HiZELS: Evolution of AGN and star-forming galaxies,” Monthly Notices of
the Royal Astronomical Society, vol. 457, no. 2. Oxford University Press,
pp. 1739–1752, 2016.'
ista: 'Sobral D, Kohn SA, Best PN, Smail I, Harrison CM, Stott J, Calhau J, Matthee
JJ. 2016. The most luminous H α emitters at z ∼ 0.8–2.23 from HiZELS: Evolution
of AGN and star-forming galaxies. Monthly Notices of the Royal Astronomical Society.
457(2), 1739–1752.'
mla: 'Sobral, David, et al. “The Most Luminous H α Emitters at z ∼ 0.8–2.23 from
HiZELS: Evolution of AGN and Star-Forming Galaxies.” Monthly Notices of the
Royal Astronomical Society, vol. 457, no. 2, Oxford University Press, 2016,
pp. 1739–52, doi:10.1093/mnras/stw022.'
short: D. Sobral, S.A. Kohn, P.N. Best, I. Smail, C.M. Harrison, J. Stott, J. Calhau,
J.J. Matthee, Monthly Notices of the Royal Astronomical Society 457 (2016) 1739–1752.
date_created: 2022-07-13T12:50:36Z
date_published: 2016-04-01T00:00:00Z
date_updated: 2022-08-19T08:15:21Z
day: '01'
doi: 10.1093/mnras/stw022
extern: '1'
external_id:
arxiv:
- '1601.02266'
intvolume: ' 457'
issue: '2'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'cosmology: observations'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1601.02266
month: '04'
oa: 1
oa_version: Preprint
page: 1739-1752
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The most luminous H α emitters at z ∼ 0.8–2.23 from HiZELS: Evolution of AGN
and star-forming galaxies'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 457
year: '2016'
...
---
_id: '11578'
abstract:
- lang: eng
text: We present the first results from our CAlibrating LYMan α with Hα (CALYMHA)
pilot survey at the Isaac Newton Telescope. We measure Lyα emission for 488 Hα
selected galaxies at z = 2.23 from High-z Emission Line Survey in the COSMOS and
UDS fields with a specially designed narrow-band filter (λc = 3918 Å, Δλ = 52
Å). We find 17 dual Hα-Lyα emitters [fLyα > 5 × 10−17 erg s−1 cm−2, of which five
are X-ray active galactic nuclei (AGN)]. For star-forming galaxies, we find a
range of Lyα escape fractions (fesc, measured with 3 arcsec apertures) from 2
to 30 per cent. These galaxies have masses from 3 × 108 M⊙ to 1011 M⊙ and dust
attenuations E(B − V) = 0–0.5. Using stacking, we measure a median escape fraction
of 1.6 ± 0.5 per cent (4.0 ± 1.0 per cent without correcting Hα for dust), but
show that this depends on galaxy properties. The stacked fesc tends to decrease
with increasing star formation rate and dust attenuation. However, at the highest
masses and dust attenuations, we detect individual galaxies with fesc much higher
than the typical values from stacking, indicating significant scatter in the values
of fesc. Relations between fesc and UV slope are bimodal, with high fesc for either
the bluest or reddest galaxies. We speculate that this bimodality and large scatter
in the values of fesc is due to additional physical mechanisms such as outflows
facilitating fesc for dusty/massive systems. Lyα is significantly more extended
than Hα and the UV. fesc continues to increase up to at least 20 kpc (3σ, 40 kpc
[2σ]) for typical star-forming galaxies and thus the aperture is the most important
predictor of fesc.
acknowledgement: "We thank the anonymous referee for constructive comments and suggestions
which have improved the quality of this work. JM acknowledges the support of a Huygens
PhD fellowship from Leiden University. DS and JM acknowledge financial support from
the Netherlands Organization for Scientific research (NWO) through a Veni fellowship,
and DS from FCT through a FCT Investigator Starting Grant and Start-up Grant (IF/01154/2012/CP0189/CT0010)
and from FCT grant PEst-OE/FIS/UI2751/2014. IO acknowledges support from the European
Research Council (ERC) in the form of Advanced Investigator Programme, COSMICISM,
321302. HR acknowledges support from the ERC Advanced Investigator programme NewClusters
321271. IRS acknowledges support from STFC (ST/L00075X/1), the ERC Advanced Investigator
programme DUSTYGAL 321334 and a Royal Society/Wolfson Merit Award. APA acknowledges
support from the Fundac¸ao para a Ciencia e para a Tecnologia (FCT) through the
Fellowship SFRH/BD/52706/2014.\r\nBased on observations made with the Isaac Newton
Telescope (proposals 2013AN002, 2013BN008, 2014AC88, 2014AN002, 2014BN006, 2014BC118)
operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio
del Roque de los Muchachos of the Instituto de Astrof´ısica de Canarias. We acknowledge
the tremendous work that has been done by both COSMOS and UKIDSS UDS/SXDF teams
in assembling such large, state-ofthe-art multi-wavelength data sets over such wide
areas, as those have been crucial for the results presented in this paper. The sample
of HAEs is publicly available from Sobral et al. (2013).\r\nWe have benefited greatly
from the publically available programming language PYTHON, including the NUMPY,
MATPLOTLIB, PYFITS, SCIPY (Jones et al. 2001; Hunter 2007; Van Der Walt, Colbert
& Varoquaux 2011) and ASTROPY (Astropy Collaboration et al. 2013) packages, the
imaging tools SEXTRACTOR, SWARP and SCAMP (Bertin & Arnouts 1996; Bertin 2006, 2010)
and the TOPCAT analysis program (Taylor 2005)."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: David
full_name: Sobral, David
last_name: Sobral
- first_name: Iván
full_name: Oteo, Iván
last_name: Oteo
- first_name: Philip
full_name: Best, Philip
last_name: Best
- first_name: Ian
full_name: Smail, Ian
last_name: Smail
- first_name: Huub
full_name: Röttgering, Huub
last_name: Röttgering
- first_name: Ana
full_name: Paulino-Afonso, Ana
last_name: Paulino-Afonso
citation:
ama: 'Matthee JJ, Sobral D, Oteo I, et al. The CALYMHA survey: Lyα escape fraction
and its dependence on galaxy properties at z = 2.23. Monthly Notices of the
Royal Astronomical Society. 2016;458(1):449-467. doi:10.1093/mnras/stw322'
apa: 'Matthee, J. J., Sobral, D., Oteo, I., Best, P., Smail, I., Röttgering, H.,
& Paulino-Afonso, A. (2016). The CALYMHA survey: Lyα escape fraction and its
dependence on galaxy properties at z = 2.23. Monthly Notices of the Royal Astronomical
Society. Oxford University Press. https://doi.org/10.1093/mnras/stw322'
chicago: 'Matthee, Jorryt J, David Sobral, Iván Oteo, Philip Best, Ian Smail, Huub
Röttgering, and Ana Paulino-Afonso. “The CALYMHA Survey: Lyα Escape Fraction and
Its Dependence on Galaxy Properties at z = 2.23.” Monthly Notices of the Royal
Astronomical Society. Oxford University Press, 2016. https://doi.org/10.1093/mnras/stw322.'
ieee: 'J. J. Matthee et al., “The CALYMHA survey: Lyα escape fraction and
its dependence on galaxy properties at z = 2.23,” Monthly Notices of the Royal
Astronomical Society, vol. 458, no. 1. Oxford University Press, pp. 449–467,
2016.'
ista: 'Matthee JJ, Sobral D, Oteo I, Best P, Smail I, Röttgering H, Paulino-Afonso
A. 2016. The CALYMHA survey: Lyα escape fraction and its dependence on galaxy
properties at z = 2.23. Monthly Notices of the Royal Astronomical Society. 458(1),
449–467.'
mla: 'Matthee, Jorryt J., et al. “The CALYMHA Survey: Lyα Escape Fraction and Its
Dependence on Galaxy Properties at z = 2.23.” Monthly Notices of the Royal
Astronomical Society, vol. 458, no. 1, Oxford University Press, 2016, pp.
449–67, doi:10.1093/mnras/stw322.'
short: J.J. Matthee, D. Sobral, I. Oteo, P. Best, I. Smail, H. Röttgering, A. Paulino-Afonso,
Monthly Notices of the Royal Astronomical Society 458 (2016) 449–467.
date_created: 2022-07-14T08:51:37Z
date_published: 2016-05-01T00:00:00Z
date_updated: 2022-08-19T08:17:19Z
day: '01'
doi: 10.1093/mnras/stw322
extern: '1'
external_id:
arxiv:
- '1602.02756'
intvolume: ' 458'
issue: '1'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
- 'galaxies: evolution'
- 'galaxies: high-redshift'
- 'galaxies: ISM'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1602.02756
month: '05'
oa: 1
oa_version: Preprint
page: 449-467
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The CALYMHA survey: Lyα escape fraction and its dependence on galaxy properties
at z = 2.23'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 458
year: '2016'
...
---
_id: '1158'
abstract:
- lang: eng
text: Speciation results from the progressive accumulation of mutations that decrease
the probability of mating between parental populations or reduce the fitness of
hybrids—the so-called species barriers. The speciation genomic literature, however,
is mainly a collection of case studies, each with its own approach and specificities,
such that a global view of the gradual process of evolution from one to two species
is currently lacking. Of primary importance is the prevalence of gene flow between
diverging entities, which is central in most species concepts and has been widely
discussed in recent years. Here, we explore the continuum of speciation thanks
to a comparative analysis of genomic data from 61 pairs of populations/species
of animals with variable levels of divergence. Gene flow between diverging gene
pools is assessed under an approximate Bayesian computation (ABC) framework. We
show that the intermediate "grey zone" of speciation, in which taxonomy
is often controversial, spans from 0.5% to 2% of net synonymous divergence, irrespective
of species life history traits or ecology. Thanks to appropriate modeling of among-locus
variation in genetic drift and introgression rate, we clarify the status of the
majority of ambiguous cases and uncover a number of cryptic species. Our analysis
also reveals the high incidence in animals of semi-isolated species (when some
but not all loci are affected by barriers to gene flow) and highlights the intrinsic
difficulty, both statistical and conceptual, of delineating species in the grey
zone of speciation.
acknowledgement: "European Research Council (ERC) https://erc.europa.eu/ (grant number
ERC grant 232971). PopPhyl project. The funder had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
French National Research Agency (ANR) http://www.agence-nationale-recherche.fr/en/project-based-funding-to-advance-french-research/
(grant number ANR-12-BSV7- 0011). HYSEA project.\r\nWe thank Aude Darracq, Vincent
Castric, Pierre-Alexandre Gagnaire, Xavier Vekemans, and John Welch for insightful
discussions. The computations were performed at the Vital-IT (http://www.vital-it.ch)
Center for high-performance computing of the SIB Swiss Institute of Bioinformatics
and the ISEM computing cluster at the platform Montpellier Bioinformatique et Biodiversité."
article_number: e2000234
author:
- first_name: Camille
full_name: Roux, Camille
last_name: Roux
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Jonathan
full_name: Romiguier, Jonathan
last_name: Romiguier
- first_name: Youann
full_name: Anciaux, Youann
last_name: Anciaux
- first_name: Nicolas
full_name: Galtier, Nicolas
last_name: Galtier
- first_name: Nicolas
full_name: Bierne, Nicolas
last_name: Bierne
citation:
ama: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. Shedding light
on the grey zone of speciation along a continuum of genomic divergence. PLoS
Biology. 2016;14(12). doi:10.1371/journal.pbio.2000234
apa: Roux, C., Fraisse, C., Romiguier, J., Anciaux, Y., Galtier, N., & Bierne,
N. (2016). Shedding light on the grey zone of speciation along a continuum of
genomic divergence. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.2000234
chicago: Roux, Camille, Christelle Fraisse, Jonathan Romiguier, Youann Anciaux,
Nicolas Galtier, and Nicolas Bierne. “Shedding Light on the Grey Zone of Speciation
along a Continuum of Genomic Divergence.” PLoS Biology. Public Library
of Science, 2016. https://doi.org/10.1371/journal.pbio.2000234.
ieee: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, and N. Bierne,
“Shedding light on the grey zone of speciation along a continuum of genomic divergence,”
PLoS Biology, vol. 14, no. 12. Public Library of Science, 2016.
ista: Roux C, Fraisse C, Romiguier J, Anciaux Y, Galtier N, Bierne N. 2016. Shedding
light on the grey zone of speciation along a continuum of genomic divergence.
PLoS Biology. 14(12), e2000234.
mla: Roux, Camille, et al. “Shedding Light on the Grey Zone of Speciation along
a Continuum of Genomic Divergence.” PLoS Biology, vol. 14, no. 12, e2000234,
Public Library of Science, 2016, doi:10.1371/journal.pbio.2000234.
short: C. Roux, C. Fraisse, J. Romiguier, Y. Anciaux, N. Galtier, N. Bierne, PLoS
Biology 14 (2016).
date_created: 2018-12-11T11:50:28Z
date_published: 2016-12-27T00:00:00Z
date_updated: 2023-02-23T14:11:16Z
day: '27'
ddc:
- '576'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1371/journal.pbio.2000234
file:
- access_level: open_access
checksum: 2bab63b068a9840efd532b9ae583f9bb
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:42Z
date_updated: 2020-07-14T12:44:36Z
file_id: '5164'
file_name: IST-2017-742-v1+1_journal.pbio.2000234.pdf
file_size: 2494348
relation: main_file
file_date_updated: 2020-07-14T12:44:36Z
has_accepted_license: '1'
intvolume: ' 14'
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
publist_id: '6200'
pubrep_id: '742'
quality_controlled: '1'
related_material:
record:
- id: '9862'
relation: research_data
status: public
- id: '9863'
relation: research_data
status: public
scopus_import: 1
status: public
title: Shedding light on the grey zone of speciation along a continuum of genomic
divergence
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2016'
...
---
_id: '1164'
abstract:
- lang: eng
text: 'A drawing of a graph G is radial if the vertices of G are placed on concentric
circles C1, … , Ck with common center c, and edges are drawn radially: every edge
intersects every circle centered at c at most once. G is radial planar if it has
a radial embedding, that is, a crossing-free radial drawing. If the vertices of
G are ordered or partitioned into ordered levels (as they are for leveled graphs),
we require that the assignment of vertices to circles corresponds to the given
ordering or leveling. A pair of edges e and f in a graph is independent if e and
f do not share a vertex. We show that a graph G is radial planar if G has a radial
drawing in which every two independent edges cross an even number of times; the
radial embedding has the same leveling as the radial drawing. In other words,
we establish the strong Hanani-Tutte theorem for radial planarity. This characterization
yields a very simple algorithm for radial planarity testing.'
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
full_name: Fulek, Radoslav
id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
last_name: Fulek
orcid: 0000-0001-8485-1774
- first_name: Michael
full_name: Pelsmajer, Michael
last_name: Pelsmajer
- first_name: Marcus
full_name: Schaefer, Marcus
last_name: Schaefer
citation:
ama: 'Fulek R, Pelsmajer M, Schaefer M. Hanani-Tutte for radial planarity II. In:
Vol 9801. Springer; 2016:468-481. doi:10.1007/978-3-319-50106-2_36'
apa: 'Fulek, R., Pelsmajer, M., & Schaefer, M. (2016). Hanani-Tutte for radial
planarity II (Vol. 9801, pp. 468–481). Presented at the GD: Graph Drawing and
Network Visualization, Athens, Greece: Springer. https://doi.org/10.1007/978-3-319-50106-2_36'
chicago: Fulek, Radoslav, Michael Pelsmajer, and Marcus Schaefer. “Hanani-Tutte
for Radial Planarity II,” 9801:468–81. Springer, 2016. https://doi.org/10.1007/978-3-319-50106-2_36.
ieee: 'R. Fulek, M. Pelsmajer, and M. Schaefer, “Hanani-Tutte for radial planarity
II,” presented at the GD: Graph Drawing and Network Visualization, Athens, Greece,
2016, vol. 9801, pp. 468–481.'
ista: 'Fulek R, Pelsmajer M, Schaefer M. 2016. Hanani-Tutte for radial planarity
II. GD: Graph Drawing and Network Visualization, LNCS, vol. 9801, 468–481.'
mla: Fulek, Radoslav, et al. Hanani-Tutte for Radial Planarity II. Vol. 9801,
Springer, 2016, pp. 468–81, doi:10.1007/978-3-319-50106-2_36.
short: R. Fulek, M. Pelsmajer, M. Schaefer, in:, Springer, 2016, pp. 468–481.
conference:
end_date: 2016-09-21
location: Athens, Greece
name: 'GD: Graph Drawing and Network Visualization'
start_date: 2016-09-19
date_created: 2018-12-11T11:50:29Z
date_published: 2016-12-08T00:00:00Z
date_updated: 2023-02-23T10:05:57Z
day: '08'
department:
- _id: UlWa
doi: 10.1007/978-3-319-50106-2_36
ec_funded: 1
external_id:
arxiv:
- '1608.08662'
intvolume: ' 9801'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1608.08662
month: '12'
oa: 1
oa_version: Preprint
page: 468 - 481
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Springer
publist_id: '6193'
quality_controlled: '1'
related_material:
record:
- id: '1113'
relation: later_version
status: public
- id: '1595'
relation: earlier_version
status: public
scopus_import: 1
status: public
title: Hanani-Tutte for radial planarity II
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9801
year: '2016'
...
---
_id: '1165'
abstract:
- lang: eng
text: We show that c-planarity is solvable in quadratic time for flat clustered
graphs with three clusters if the combinatorial embedding of the underlying graph
is fixed. In simpler graph-theoretical terms our result can be viewed as follows.
Given a graph G with the vertex set partitioned into three parts embedded on a
2-sphere, our algorithm decides if we can augment G by adding edges without creating
an edge-crossing so that in the resulting spherical graph the vertices of each
part induce a connected sub-graph. We proceed by a reduction to the problem of
testing the existence of a perfect matching in planar bipartite graphs. We formulate
our result in a slightly more general setting of cyclic clustered graphs, i.e.,
the simple graph obtained by contracting each cluster, where we disregard loops
and multi-edges, is a cycle.
acknowledgement: "R. Fulek—The research leading to these results has received funding
from the People Programme (Marie Curie Actions) of the European Union’s Seventh
Framework Programme (FP7/2007-2013) under REA grant agreement no [291734].\r\nI
would like to thank Jan Kynčl and Dömötör Pálvölgyi for many comments and suggestions
that helped to improve the presentation of the result."
alternative_title:
- LNCS
author:
- first_name: Radoslav
full_name: Fulek, Radoslav
id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
last_name: Fulek
orcid: 0000-0001-8485-1774
citation:
ama: 'Fulek R. C-planarity of embedded cyclic c-graphs. In: Vol 9801. Springer;
2016:94-106. doi:10.1007/978-3-319-50106-2_8'
apa: 'Fulek, R. (2016). C-planarity of embedded cyclic c-graphs (Vol. 9801, pp.
94–106). Presented at the GD: Graph Drawing and Network Visualization, Athens,
Greece: Springer. https://doi.org/10.1007/978-3-319-50106-2_8'
chicago: Fulek, Radoslav. “C-Planarity of Embedded Cyclic c-Graphs,” 9801:94–106.
Springer, 2016. https://doi.org/10.1007/978-3-319-50106-2_8.
ieee: 'R. Fulek, “C-planarity of embedded cyclic c-graphs,” presented at the GD:
Graph Drawing and Network Visualization, Athens, Greece, 2016, vol. 9801, pp.
94–106.'
ista: 'Fulek R. 2016. C-planarity of embedded cyclic c-graphs. GD: Graph Drawing
and Network Visualization, LNCS, vol. 9801, 94–106.'
mla: Fulek, Radoslav. C-Planarity of Embedded Cyclic c-Graphs. Vol. 9801,
Springer, 2016, pp. 94–106, doi:10.1007/978-3-319-50106-2_8.
short: R. Fulek, in:, Springer, 2016, pp. 94–106.
conference:
end_date: 2016-09-21
location: Athens, Greece
name: 'GD: Graph Drawing and Network Visualization'
start_date: 2016-09-19
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-08T00:00:00Z
date_updated: 2023-09-27T12:14:48Z
day: '08'
department:
- _id: UlWa
doi: 10.1007/978-3-319-50106-2_8
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1602.01346
month: '12'
oa: 1
oa_version: Preprint
page: 94 - 106
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication_status: published
publisher: Springer
publist_id: '6192'
quality_controlled: '1'
related_material:
record:
- id: '794'
relation: later_version
status: public
scopus_import: 1
status: public
title: C-planarity of embedded cyclic c-graphs
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: '9801 '
year: '2016'
...
---
_id: '1166'
abstract:
- lang: eng
text: POMDPs are standard models for probabilistic planning problems, where an agent
interacts with an uncertain environment. We study the problem of almost-sure reachability,
where given a set of target states, the question is to decide whether there is
a policy to ensure that the target set is reached with probability 1 (almost-surely).
While in general the problem is EXPTIMEcomplete, in many practical cases policies
with a small amount of memory suffice. Moreover, the existing solution to the
problem is explicit, which first requires to construct explicitly an exponential
reduction to a belief-support MDP. In this work, we first study the existence
of observation-stationary strategies, which is NP-complete, and then small-memory
strategies. We present a symbolic algorithm by an efficient encoding to SAT and
using a SAT solver for the problem. We report experimental results demonstrating
the scalability of our symbolic (SAT-based) approach. © 2016, Association for
the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Chmelik, Martin
id: 3624234E-F248-11E8-B48F-1D18A9856A87
last_name: Chmelik
- first_name: Jessica
full_name: Davies, Jessica
id: 378E0060-F248-11E8-B48F-1D18A9856A87
last_name: Davies
citation:
ama: 'Chatterjee K, Chmelik M, Davies J. A symbolic SAT based algorithm for almost
sure reachability with small strategies in pomdps. In: Proceedings of the Thirtieth
AAAI Conference on Artificial Intelligence. Vol 2016. AAAI Press; 2016:3225-3232.'
apa: 'Chatterjee, K., Chmelik, M., & Davies, J. (2016). A symbolic SAT based
algorithm for almost sure reachability with small strategies in pomdps. In Proceedings
of the Thirtieth AAAI Conference on Artificial Intelligence (Vol. 2016, pp.
3225–3232). Phoenix, AZ, USA: AAAI Press.'
chicago: Chatterjee, Krishnendu, Martin Chmelik, and Jessica Davies. “A Symbolic
SAT Based Algorithm for Almost Sure Reachability with Small Strategies in Pomdps.”
In Proceedings of the Thirtieth AAAI Conference on Artificial Intelligence,
2016:3225–32. AAAI Press, 2016.
ieee: K. Chatterjee, M. Chmelik, and J. Davies, “A symbolic SAT based algorithm
for almost sure reachability with small strategies in pomdps,” in Proceedings
of the Thirtieth AAAI Conference on Artificial Intelligence, Phoenix, AZ,
USA, 2016, vol. 2016, pp. 3225–3232.
ista: 'Chatterjee K, Chmelik M, Davies J. 2016. A symbolic SAT based algorithm for
almost sure reachability with small strategies in pomdps. Proceedings of the Thirtieth
AAAI Conference on Artificial Intelligence. AAAI: Conference on Artificial Intelligence
vol. 2016, 3225–3232.'
mla: Chatterjee, Krishnendu, et al. “A Symbolic SAT Based Algorithm for Almost Sure
Reachability with Small Strategies in Pomdps.” Proceedings of the Thirtieth
AAAI Conference on Artificial Intelligence, vol. 2016, AAAI Press, 2016, pp.
3225–32.
short: K. Chatterjee, M. Chmelik, J. Davies, in:, Proceedings of the Thirtieth AAAI
Conference on Artificial Intelligence, AAAI Press, 2016, pp. 3225–3232.
conference:
end_date: 2016-02-17
location: Phoenix, AZ, USA
name: 'AAAI: Conference on Artificial Intelligence'
start_date: 2016-02-12
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-02T00:00:00Z
date_updated: 2023-02-23T12:26:41Z
day: '02'
department:
- _id: KrCh
- _id: ToHe
ec_funded: 1
intvolume: ' 2016'
language:
- iso: eng
month: '12'
oa_version: None
page: 3225 - 3232
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Proceedings of the Thirtieth AAAI Conference on Artificial Intelligence
publication_status: published
publisher: AAAI Press
publist_id: '6191'
quality_controlled: '1'
related_material:
link:
- relation: table_of_contents
url: https://dl.acm.org/citation.cfm?id=3016355
record:
- id: '5443'
relation: earlier_version
status: public
status: public
title: A symbolic SAT based algorithm for almost sure reachability with small strategies
in pomdps
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 2016
year: '2016'
...
---
_id: '1167'
abstract:
- lang: eng
text: Evolutionary pathways describe trajectories of biological evolution in the
space of different variants of organisms (genotypes). The probability of existence
and the number of evolutionary pathways that lead from a given genotype to a better-adapted
genotype are important measures of accessibility of local fitness optima and the
reproducibility of evolution. Both quantities have been studied in simple mathematical
models where genotypes are represented as binary sequences of two types of basic
units, and the network of permitted mutations between the genotypes is a hypercube
graph. However, it is unclear how these results translate to the biologically
relevant case in which genotypes are represented by sequences of more than two
units, for example four nucleotides (DNA) or 20 amino acids (proteins), and the
mutational graph is not the hypercube. Here we investigate accessibility of the
best-adapted genotype in the general case of K > 2 units. Using computer generated
and experimental fitness landscapes we show that accessibility of the global fitness
maximum increases with K and can be much higher than for binary sequences. The
increase in accessibility comes from the increase in the number of indirect trajectories
exploited by evolution for higher K. As one of the consequences, the fraction
of genotypes that are accessible increases by three orders of magnitude when the
number of units K increases from 2 to 16 for landscapes of size N ∼ 106genotypes.
This suggests that evolution can follow many different trajectories on such landscapes
and the reconstruction of evolutionary pathways from experimental data might be
an extremely difficult task.
acknowledgement: MZ acknowledges the Polish National Science Centre grant no. DEC-2012/07/N/NZ2/00107.
BW was supported by the Scottish Government/Royal Society of Edinburgh Personal
Research Fellowship. We thank Marjon de Vos and Oliver Martin for critically reading
the manuscript.
article_number: e1005218
article_processing_charge: No
author:
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
- first_name: Zdzisław
full_name: Burda, Zdzisław
last_name: Burda
- first_name: Bartłomiej
full_name: Wacław, Bartłomiej
last_name: Wacław
citation:
ama: Zagórski MP, Burda Z, Wacław B. Beyond the hypercube evolutionary accessibility
of fitness landscapes with realistic mutational networks. PLoS Computational
Biology. 2016;12(12). doi:10.1371/journal.pcbi.1005218
apa: Zagórski, M. P., Burda, Z., & Wacław, B. (2016). Beyond the hypercube evolutionary
accessibility of fitness landscapes with realistic mutational networks. PLoS
Computational Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1005218
chicago: Zagórski, Marcin P, Zdzisław Burda, and Bartłomiej Wacław. “Beyond the
Hypercube Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational
Networks.” PLoS Computational Biology. Public Library of Science, 2016.
https://doi.org/10.1371/journal.pcbi.1005218.
ieee: M. P. Zagórski, Z. Burda, and B. Wacław, “Beyond the hypercube evolutionary
accessibility of fitness landscapes with realistic mutational networks,” PLoS
Computational Biology, vol. 12, no. 12. Public Library of Science, 2016.
ista: Zagórski MP, Burda Z, Wacław B. 2016. Beyond the hypercube evolutionary accessibility
of fitness landscapes with realistic mutational networks. PLoS Computational Biology.
12(12), e1005218.
mla: Zagórski, Marcin P., et al. “Beyond the Hypercube Evolutionary Accessibility
of Fitness Landscapes with Realistic Mutational Networks.” PLoS Computational
Biology, vol. 12, no. 12, e1005218, Public Library of Science, 2016, doi:10.1371/journal.pcbi.1005218.
short: M.P. Zagórski, Z. Burda, B. Wacław, PLoS Computational Biology 12 (2016).
date_created: 2018-12-11T11:50:30Z
date_published: 2016-12-09T00:00:00Z
date_updated: 2023-02-23T14:11:22Z
day: '09'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1371/journal.pcbi.1005218
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title: Beyond the hypercube evolutionary accessibility of fitness landscapes with
realistic mutational networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
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...
---
_id: '1170'
abstract:
- lang: eng
text: The increasing complexity of dynamic models in systems and synthetic biology
poses computational challenges especially for the identification of model parameters.
While modularization of the corresponding optimization problems could help reduce
the “curse of dimensionality,” abundant feedback and crosstalk mechanisms prohibit
a simple decomposition of most biomolecular networks into subnetworks, or modules.
Drawing on ideas from network modularization and multiple-shooting optimization,
we present here a modular parameter identification approach that explicitly allows
for such interdependencies. Interfaces between our modules are given by the experimentally
measured molecular species. This definition allows deriving good (initial) estimates
for the inter-module communication directly from the experimental data. Given
these estimates, the states and parameter sensitivities of different modules can
be integrated independently. To achieve consistency between modules, we iteratively
adjust the estimates for inter-module communication while optimizing the parameters.
After convergence to an optimal parameter set---but not during earlier iterations---the
intermodule communication as well as the individual modules\' state dynamics agree
with the dynamics of the nonmodularized network. Our modular parameter identification
approach allows for easy parallelization; it can reduce the computational complexity
for larger networks and decrease the probability to converge to suboptimal local
minima. We demonstrate the algorithm\'s performance in parameter estimation for
two biomolecular networks, a synthetic genetic oscillator and a mammalian signaling
pathway.
author:
- first_name: Moritz
full_name: Lang, Moritz
id: 29E0800A-F248-11E8-B48F-1D18A9856A87
last_name: Lang
- first_name: Jörg
full_name: Stelling, Jörg
last_name: Stelling
citation:
ama: Lang M, Stelling J. Modular parameter identification of biomolecular networks.
SIAM Journal on Scientific Computing. 2016;38(6):B988-B1008. doi:10.1137/15M103306X
apa: Lang, M., & Stelling, J. (2016). Modular parameter identification of biomolecular
networks. SIAM Journal on Scientific Computing. Society for Industrial
and Applied Mathematics . https://doi.org/10.1137/15M103306X
chicago: Lang, Moritz, and Jörg Stelling. “Modular Parameter Identification of Biomolecular
Networks.” SIAM Journal on Scientific Computing. Society for Industrial
and Applied Mathematics , 2016. https://doi.org/10.1137/15M103306X.
ieee: M. Lang and J. Stelling, “Modular parameter identification of biomolecular
networks,” SIAM Journal on Scientific Computing, vol. 38, no. 6. Society
for Industrial and Applied Mathematics , pp. B988–B1008, 2016.
ista: Lang M, Stelling J. 2016. Modular parameter identification of biomolecular
networks. SIAM Journal on Scientific Computing. 38(6), B988–B1008.
mla: Lang, Moritz, and Jörg Stelling. “Modular Parameter Identification of Biomolecular
Networks.” SIAM Journal on Scientific Computing, vol. 38, no. 6, Society
for Industrial and Applied Mathematics , 2016, pp. B988–1008, doi:10.1137/15M103306X.
short: M. Lang, J. Stelling, SIAM Journal on Scientific Computing 38 (2016) B988–B1008.
date_created: 2018-12-11T11:50:31Z
date_published: 2016-11-15T00:00:00Z
date_updated: 2021-01-12T06:48:49Z
day: '15'
ddc:
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- _id: GaTk
doi: 10.1137/15M103306X
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oa_version: Submitted Version
page: B988 - B1008
publication: SIAM Journal on Scientific Computing
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pubrep_id: '811'
quality_controlled: '1'
scopus_import: 1
status: public
title: Modular parameter identification of biomolecular networks
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 38
year: '2016'
...