---
_id: '1016'
abstract:
- lang: eng
text: The integrity and dynamic properties of the microtubule cytoskeleton are indispensable
for the development of the mammalian brain. Consequently, mutations in the genes
that encode the structural component (the α/β-tubulin heterodimer) can give rise
to severe, sporadic neurodevelopmental disorders. These are commonly referred
to as the tubulinopathies. Here we report the addition of recessive quadrupedalism,
also known as Uner Tan syndrome (UTS), to the growing list of diseases caused
by tubulin variants. Analysis of a consanguineous UTS family identified a biallelic
TUBB2B mutation, resulting in a p.R390Q amino acid substitution. In addition to
the identifying quadrupedal locomotion, all three patients showed severe cerebellar
hypoplasia. None, however, displayed the basal ganglia malformations typically
associated with TUBB2B mutations. Functional analysis of the R390Q substitution
revealed that it did not affect the ability of β-tubulin to fold or become assembled
into the α/β-heterodimer, nor did it influence the incorporation of mutant-containing
heterodimers into microtubule polymers. The 390Q mutation in S. cerevisiae TUB2
did not affect growth under basal conditions, but did result in increased sensitivity
to microtubule-depolymerizing drugs, indicative of a mild impact of this mutation
on microtubule function. The TUBB2B mutation described here represents an unusual
recessive mode of inheritance for missense-mediated tubulinopathies and reinforces
the sensitivity of the developing cerebellum to microtubule defects.
article_processing_charge: No
author:
- first_name: Martin
full_name: Breuss, Martin
last_name: Breuss
- first_name: Thai
full_name: Nguyen, Thai
last_name: Nguyen
- first_name: Anjana
full_name: Srivatsan, Anjana
last_name: Srivatsan
- first_name: Ines
full_name: Leca, Ines
last_name: Leca
- first_name: Guoling
full_name: Tian, Guoling
last_name: Tian
- first_name: Tanja
full_name: Fritz, Tanja
last_name: Fritz
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Damir
full_name: Musaev, Damir
last_name: Musaev
- first_name: Jennifer
full_name: Mcevoy Venneri, Jennifer
last_name: Mcevoy Venneri
- first_name: James
full_name: Kiely, James
last_name: Kiely
- first_name: Rasim
full_name: Rosti, Rasim
last_name: Rosti
- first_name: Eric
full_name: Scott, Eric
last_name: Scott
- first_name: Uner
full_name: Tan, Uner
last_name: Tan
- first_name: Richard
full_name: Kolodner, Richard
last_name: Kolodner
- first_name: Nicholas
full_name: Cowan, Nicholas
last_name: Cowan
- first_name: David
full_name: Keays, David
last_name: Keays
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
citation:
ama: Breuss M, Nguyen T, Srivatsan A, et al. Uner Tan syndrome caused by a homozygous
TUBB2B mutation affecting microtubule stability. Human Molecular Genetics.
2017;26(2):258-269. doi:10.1093/hmg/ddw383
apa: Breuss, M., Nguyen, T., Srivatsan, A., Leca, I., Tian, G., Fritz, T., … Gleeson,
J. (2017). Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting
microtubule stability. Human Molecular Genetics. Oxford University Press.
https://doi.org/10.1093/hmg/ddw383
chicago: Breuss, Martin, Thai Nguyen, Anjana Srivatsan, Ines Leca, Guoling Tian,
Tanja Fritz, Andi H Hansen, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B
Mutation Affecting Microtubule Stability.” Human Molecular Genetics. Oxford
University Press, 2017. https://doi.org/10.1093/hmg/ddw383.
ieee: M. Breuss et al., “Uner Tan syndrome caused by a homozygous TUBB2B
mutation affecting microtubule stability,” Human Molecular Genetics, vol.
26, no. 2. Oxford University Press, pp. 258–269, 2017.
ista: Breuss M, Nguyen T, Srivatsan A, Leca I, Tian G, Fritz T, Hansen AH, Musaev
D, Mcevoy Venneri J, Kiely J, Rosti R, Scott E, Tan U, Kolodner R, Cowan N, Keays
D, Gleeson J. 2017. Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting
microtubule stability. Human Molecular Genetics. 26(2), 258–269.
mla: Breuss, Martin, et al. “Uner Tan Syndrome Caused by a Homozygous TUBB2B Mutation
Affecting Microtubule Stability.” Human Molecular Genetics, vol. 26, no.
2, Oxford University Press, 2017, pp. 258–69, doi:10.1093/hmg/ddw383.
short: M. Breuss, T. Nguyen, A. Srivatsan, I. Leca, G. Tian, T. Fritz, A.H. Hansen,
D. Musaev, J. Mcevoy Venneri, J. Kiely, R. Rosti, E. Scott, U. Tan, R. Kolodner,
N. Cowan, D. Keays, J. Gleeson, Human Molecular Genetics 26 (2017) 258–269.
date_created: 2018-12-11T11:49:42Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-09-22T09:42:42Z
day: '01'
department:
- _id: SiHi
doi: 10.1093/hmg/ddw383
external_id:
isi:
- '000397066400002'
intvolume: ' 26'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 258 - 269
publication: Human Molecular Genetics
publication_identifier:
issn:
- '09646906'
publication_status: published
publisher: Oxford University Press
publist_id: '6379'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule
stability
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 26
year: '2017'
...
---
_id: '1017'
abstract:
- lang: eng
text: The development of the vertebrate central nervous system is reliant on a complex
cascade of biological processes that include mitotic division, relocation of migrating
neurons, and the extension of dendritic and axonal processes. Each of these cellular
events requires the diverse functional repertoire of the microtubule cytoskeleton
for the generation of forces, assembly of macromolecular complexes and transport
of molecules and organelles. The tubulins are a multi-gene family that encode
for the constituents of microtubules, and have been implicated in a spectrum of
neurological disorders. Evidence is building that different tubulins tune the
functional properties of the microtubule cytoskeleton dependent on the cell type,
developmental profile and subcellular localisation. Here we review of the origins
of the functional specification of the tubulin gene family in the developing brain
at a transcriptional, translational, and post-transcriptional level. We remind
the reader that tubulins are not just loading controls for your average Western
blot.
article_processing_charge: No
author:
- first_name: Martin
full_name: Breuss, Martin
last_name: Breuss
- first_name: Ines
full_name: Leca, Ines
last_name: Leca
- first_name: Thomas
full_name: Gstrein, Thomas
last_name: Gstrein
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: David
full_name: Keays, David
last_name: Keays
citation:
ama: 'Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. Tubulins and brain development:
The origins of functional specification. Molecular and Cellular Neuroscience.
2017;84:58-67. doi:10.1016/j.mcn.2017.03.002'
apa: 'Breuss, M., Leca, I., Gstrein, T., Hansen, A. H., & Keays, D. (2017).
Tubulins and brain development: The origins of functional specification. Molecular
and Cellular Neuroscience. Academic Press. https://doi.org/10.1016/j.mcn.2017.03.002'
chicago: 'Breuss, Martin, Ines Leca, Thomas Gstrein, Andi H Hansen, and David Keays.
“Tubulins and Brain Development: The Origins of Functional Specification.” Molecular
and Cellular Neuroscience. Academic Press, 2017. https://doi.org/10.1016/j.mcn.2017.03.002.'
ieee: 'M. Breuss, I. Leca, T. Gstrein, A. H. Hansen, and D. Keays, “Tubulins and
brain development: The origins of functional specification,” Molecular and
Cellular Neuroscience, vol. 84. Academic Press, pp. 58–67, 2017.'
ista: 'Breuss M, Leca I, Gstrein T, Hansen AH, Keays D. 2017. Tubulins and brain
development: The origins of functional specification. Molecular and Cellular Neuroscience.
84, 58–67.'
mla: 'Breuss, Martin, et al. “Tubulins and Brain Development: The Origins of Functional
Specification.” Molecular and Cellular Neuroscience, vol. 84, Academic
Press, 2017, pp. 58–67, doi:10.1016/j.mcn.2017.03.002.'
short: M. Breuss, I. Leca, T. Gstrein, A.H. Hansen, D. Keays, Molecular and Cellular
Neuroscience 84 (2017) 58–67.
date_created: 2018-12-11T11:49:42Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2023-09-22T09:42:15Z
day: '01'
ddc:
- '571'
department:
- _id: SiHi
doi: 10.1016/j.mcn.2017.03.002
external_id:
isi:
- '000415140700007'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:19Z
date_updated: 2018-12-12T10:09:19Z
file_id: '4742'
file_name: IST-2017-806-v1+2_1-s2.0-S1044743116302500-main_1_.pdf
file_size: 1436377
relation: main_file
file_date_updated: 2018-12-12T10:09:19Z
has_accepted_license: '1'
intvolume: ' 84'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
page: 58 - 67
publication: Molecular and Cellular Neuroscience
publication_identifier:
issn:
- '10447431'
publication_status: published
publisher: Academic Press
publist_id: '6377'
pubrep_id: '806'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Tubulins and brain development: The origins of functional specification'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 84
year: '2017'
...
---
_id: '10175'
abstract:
- lang: eng
text: We study periodic homogenization by Γ-convergence of integral functionals
with integrands W(x,ξ) having no polynomial growth and which are both not necessarily
continuous with respect to the space variable and not necessarily convex with
respect to the matrix variable. This allows to deal with homogenization of composite
hyperelastic materials consisting of two or more periodic components whose the
energy densities tend to infinity as the volume of matter tends to zero, i.e.,
W(x,ξ)=∑j∈J1Vj(x)Hj(ξ) where {Vj}j∈J is a finite family of open disjoint subsets
of RN, with |∂Vj|=0 for all j∈J and ∣∣RN∖⋃j∈JVj|=0, and, for each j∈J, Hj(ξ)→∞
as detξ→0. In fact, our results apply to integrands of type W(x,ξ)=a(x)H(ξ) when
H(ξ)→∞ as detξ→0 and a∈L∞(RN;[0,∞[) is 1-periodic and is either continuous almost
everywhere or not continuous. When a is not continuous, we obtain a density homogenization
formula which is a priori different from the classical one by Braides–Müller.
Although applications to hyperelasticity are limited due to the fact that our
framework is not consistent with the constraint of noninterpenetration of the
matter, our results can be of technical interest to analysis of homogenization
of integral functionals.
article_processing_charge: No
article_type: original
author:
- first_name: Omar
full_name: Anza Hafsa, Omar
last_name: Anza Hafsa
- first_name: Nicolas
full_name: Clozeau, Nicolas
id: fea1b376-906f-11eb-847d-b2c0cf46455b
last_name: Clozeau
- first_name: Jean-Philippe
full_name: Mandallena, Jean-Philippe
last_name: Mandallena
citation:
ama: Anza Hafsa O, Clozeau N, Mandallena J-P. Homogenization of nonconvex unbounded
singular integrals. Annales mathématiques Blaise Pascal. 2017;24(2):135-193.
doi:10.5802/ambp.367
apa: Anza Hafsa, O., Clozeau, N., & Mandallena, J.-P. (2017). Homogenization
of nonconvex unbounded singular integrals. Annales Mathématiques Blaise Pascal.
Université Clermont Auvergne. https://doi.org/10.5802/ambp.367
chicago: Anza Hafsa, Omar, Nicolas Clozeau, and Jean-Philippe Mandallena. “Homogenization
of Nonconvex Unbounded Singular Integrals.” Annales Mathématiques Blaise Pascal.
Université Clermont Auvergne, 2017. https://doi.org/10.5802/ambp.367.
ieee: O. Anza Hafsa, N. Clozeau, and J.-P. Mandallena, “Homogenization of nonconvex
unbounded singular integrals,” Annales mathématiques Blaise Pascal, vol.
24, no. 2. Université Clermont Auvergne, pp. 135–193, 2017.
ista: Anza Hafsa O, Clozeau N, Mandallena J-P. 2017. Homogenization of nonconvex
unbounded singular integrals. Annales mathématiques Blaise Pascal. 24(2), 135–193.
mla: Anza Hafsa, Omar, et al. “Homogenization of Nonconvex Unbounded Singular Integrals.”
Annales Mathématiques Blaise Pascal, vol. 24, no. 2, Université Clermont
Auvergne, 2017, pp. 135–93, doi:10.5802/ambp.367.
short: O. Anza Hafsa, N. Clozeau, J.-P. Mandallena, Annales Mathématiques Blaise
Pascal 24 (2017) 135–193.
date_created: 2021-10-23T10:54:23Z
date_published: 2017-11-20T00:00:00Z
date_updated: 2021-10-28T15:16:25Z
day: '20'
ddc:
- '510'
doi: 10.5802/ambp.367
extern: '1'
file:
- access_level: open_access
checksum: 18f40d13dc5d1e24438260b1875b886f
content_type: application/pdf
creator: cziletti
date_created: 2021-10-28T15:02:56Z
date_updated: 2021-10-28T15:02:56Z
file_id: '10194'
file_name: 2017_AMBP_AnzaHafsa.pdf
file_size: 850726
relation: main_file
success: 1
file_date_updated: 2021-10-28T15:02:56Z
has_accepted_license: '1'
intvolume: ' 24'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/3.0/
month: '11'
oa: 1
oa_version: Published Version
page: 135-193
publication: Annales mathématiques Blaise Pascal
publication_identifier:
eissn:
- 2118-7436
issn:
- 1259-1734
publication_status: published
publisher: Université Clermont Auvergne
quality_controlled: '1'
status: public
title: Homogenization of nonconvex unbounded singular integrals
tmp:
image: /images/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/3.0/legalcode
name: Creative Commons Attribution-NoDerivs 3.0 Unported (CC BY-ND 3.0)
short: CC BY-ND (3.0)
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 24
year: '2017'
...
---
_id: '1018'
abstract:
- lang: eng
text: In plants, the multistep phosphorelay (MSP) pathway mediates a range of regulatory
processes, including those activated by cytokinins. The crosstalk between cytokinin
response and light is known for a long time. However, the molecular mechanism
underlying the interactionbetween light and cytokinin signaling remains elusive.
In the screen for upstream regulators we identified a LONG PALE HYPOCOTYL (LPH)
gene whose activity is indispensable for spatiotemporally correct expression of
CYTOKININ INDEPENDENT-1 (CKI1), encoding the constitutively active sensor histidine
kinase that activates MSP signaling. lph is a new allele of HEME OXYGENASE 1 (HY1)
which encodes the key protein in the biosynthesis of phytochromobilin, a cofactor
of photoconvertiblephytochromes. Our analysis confirmed the light-dependent regulation
oftheCKI1 expression pattern. We show that CKI1 expression is under the control
of phytochrome A (phyA), functioning as a dual (both positive and negative) regulator
of CKI1 expression, presumably via the phyA-regulated transcription factors PHYTOCHROME
INTERACTING FACTOR 3 (PIF3) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Changes in
CKI1 expression observed in lph/hy1-7 and phy mutants correlatewithmisregulation
of MSP signaling, changedcytokinin sensitivity and developmental aberrations,previously
shown to be associated with cytokinin and/or CKI1 action. Besides that, we demonstrate
novel role of phyA-dependent CKI1 expression in the hypocotyl elongation and hook
development during skotomorphogenesis. Based on these results, we propose that
the light-dependent regulation of CKI1 provides a plausible mechanistic link underlying
the well-known interaction between light- and cytokinin-controlled plant development.
article_processing_charge: No
author:
- first_name: Tereza
full_name: Dobisova, Tereza
last_name: Dobisova
- first_name: Vendula
full_name: Hrdinova, Vendula
last_name: Hrdinova
- first_name: Candela
full_name: Cuesta, Candela
id: 33A3C818-F248-11E8-B48F-1D18A9856A87
last_name: Cuesta
orcid: 0000-0003-1923-2410
- first_name: Sarka
full_name: Michlickova, Sarka
last_name: Michlickova
- first_name: Ivana
full_name: Urbankova, Ivana
last_name: Urbankova
- first_name: Romana
full_name: Hejatkova, Romana
last_name: Hejatkova
- first_name: Petra
full_name: Zadnikova, Petra
last_name: Zadnikova
- first_name: Markéta
full_name: Pernisová, Markéta
last_name: Pernisová
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Jan
full_name: Hejátko, Jan
last_name: Hejátko
citation:
ama: Dobisova T, Hrdinova V, Cuesta C, et al. Light regulated expression of sensor
histidine kinase CKI1 controls cytokinin related development. Plant Physiology.
2017;174(1):387-404. doi:10.1104/pp.16.01964
apa: Dobisova, T., Hrdinova, V., Cuesta, C., Michlickova, S., Urbankova, I., Hejatkova,
R., … Hejátko, J. (2017). Light regulated expression of sensor histidine kinase
CKI1 controls cytokinin related development. Plant Physiology. American
Society of Plant Biologists. https://doi.org/10.1104/pp.16.01964
chicago: Dobisova, Tereza, Vendula Hrdinova, Candela Cuesta, Sarka Michlickova,
Ivana Urbankova, Romana Hejatkova, Petra Zadnikova, Markéta Pernisová, Eva Benková,
and Jan Hejátko. “Light Regulated Expression of Sensor Histidine Kinase CKI1 Controls
Cytokinin Related Development.” Plant Physiology. American Society of Plant
Biologists, 2017. https://doi.org/10.1104/pp.16.01964.
ieee: T. Dobisova et al., “Light regulated expression of sensor histidine
kinase CKI1 controls cytokinin related development,” Plant Physiology,
vol. 174, no. 1. American Society of Plant Biologists, pp. 387–404, 2017.
ista: Dobisova T, Hrdinova V, Cuesta C, Michlickova S, Urbankova I, Hejatkova R,
Zadnikova P, Pernisová M, Benková E, Hejátko J. 2017. Light regulated expression
of sensor histidine kinase CKI1 controls cytokinin related development. Plant
Physiology. 174(1), 387–404.
mla: Dobisova, Tereza, et al. “Light Regulated Expression of Sensor Histidine Kinase
CKI1 Controls Cytokinin Related Development.” Plant Physiology, vol. 174,
no. 1, American Society of Plant Biologists, 2017, pp. 387–404, doi:10.1104/pp.16.01964.
short: T. Dobisova, V. Hrdinova, C. Cuesta, S. Michlickova, I. Urbankova, R. Hejatkova,
P. Zadnikova, M. Pernisová, E. Benková, J. Hejátko, Plant Physiology 174 (2017)
387–404.
date_created: 2018-12-11T11:49:43Z
date_published: 2017-05-17T00:00:00Z
date_updated: 2023-09-22T09:41:48Z
day: '17'
department:
- _id: EvBe
doi: 10.1104/pp.16.01964
external_id:
isi:
- '000402057200028'
intvolume: ' 174'
isi: 1
issue: '1'
language:
- iso: eng
month: '05'
oa_version: None
page: 387 - 404
publication: Plant Physiology
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '6375'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Light regulated expression of sensor histidine kinase CKI1 controls cytokinin
related development
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 174
year: '2017'
...
---
_id: '1019'
abstract:
- lang: eng
text: As a consequence of its difference in copy number between males and females,
the X chromosome is subject to unique evolutionary forces and gene regulatory
mechanisms. Previous studies of Drosophila melanogaster have shown that the expression
of X-linked, testis-specific reporter genes is suppressed in the male germline.
However, it is not known whether this phenomenon is restricted to testis-expressed
genes or if it is a more general property of genes with tissue-specific expression,
which are also underrepresented on the X chromosome. To test this, we compared
the expression of three tissue-specific reporter genes (ovary, accessory gland
and Malpighian tubule) inserted at various autosomal and X-chromosomal locations.
In contrast to testis-specific reporter genes, we found no reduction of X-linked
expression in any of the other tissues. In accessory gland and Malpighian tubule,
we detected higher expression of the X-linked reporter genes, which suggests that
they are at least partially dosage compensated. We found no difference in the
tissue-specificity of X-linked and autosomal reporter genes. These findings indicate
that, in general, the X chromosome is not a detrimental environment for tissue-specific
gene expression and that the suppression of X-linked expression is limited to
the male germline.
article_processing_charge: No
author:
- first_name: Eliza
full_name: Argyridou, Eliza
last_name: Argyridou
- first_name: Ann K
full_name: Huylmans, Ann K
id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
last_name: Huylmans
orcid: 0000-0001-8871-4961
- first_name: Annabella
full_name: Königer, Annabella
last_name: Königer
- first_name: John
full_name: Parsch, John
last_name: Parsch
citation:
ama: Argyridou E, Huylmans AK, Königer A, Parsch J. X-linkage is not a general inhibitor
of tissue-specific gene expression in Drosophila melanogaster. Heredity.
2017;119(1):27-34. doi:10.1038/hdy.2017.12
apa: Argyridou, E., Huylmans, A. K., Königer, A., & Parsch, J. (2017). X-linkage
is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.
Heredity. Nature Publishing Group. https://doi.org/10.1038/hdy.2017.12
chicago: Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “X-Linkage
Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.”
Heredity. Nature Publishing Group, 2017. https://doi.org/10.1038/hdy.2017.12.
ieee: E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “X-linkage is not
a general inhibitor of tissue-specific gene expression in Drosophila melanogaster,”
Heredity, vol. 119, no. 1. Nature Publishing Group, pp. 27–34, 2017.
ista: Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. X-linkage is not a general
inhibitor of tissue-specific gene expression in Drosophila melanogaster. Heredity.
119(1), 27–34.
mla: Argyridou, Eliza, et al. “X-Linkage Is Not a General Inhibitor of Tissue-Specific
Gene Expression in Drosophila Melanogaster.” Heredity, vol. 119, no. 1,
Nature Publishing Group, 2017, pp. 27–34, doi:10.1038/hdy.2017.12.
short: E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, Heredity 119 (2017) 27–34.
date_created: 2018-12-11T11:49:43Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2023-09-22T09:41:21Z
day: '01'
department:
- _id: BeVi
doi: 10.1038/hdy.2017.12
external_id:
isi:
- '000405397800004'
intvolume: ' 119'
isi: 1
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 27 - 34
publication: Heredity
publication_identifier:
issn:
- 0018067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '6374'
quality_controlled: '1'
related_material:
record:
- id: '9861'
relation: research_data
status: public
scopus_import: '1'
status: public
title: X-linkage is not a general inhibitor of tissue-specific gene expression in
Drosophila melanogaster
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 119
year: '2017'
...
---
_id: '1020'
abstract:
- lang: eng
text: Cellulose is the most abundant biopolymer on Earth. Cellulose fibers, such
as the one extracted form cotton or woodpulp, have been used by humankind for
hundreds of years to make textiles and paper. Here we show how, by engineering
light-matter interaction, we can optimize light scattering using exclusively cellulose
nanocrystals. The produced material is sustainable, biocompatible, and when compared
to ordinary microfiber-based paper, it shows enhanced scattering strength (×4),
yielding a transport mean free path as low as 3.5 μm in the visible light range.
The experimental results are in a good agreement with the theoretical predictions
obtained with a diffusive model for light propagation.
acknowledgement: This research was funded by the EPSRC (EP/M027961/1), the Leverhulme
Trust (RPG-2014-238), Royal Society (RG140457), the BBSRC David Phillips fellowship
(BB/K014617/1), and the European Research Council (ERC-2014-STG H2020 639088). All
data created during this research are provided in full in the results section and
Supporting Information. They are openly available from figshare and can be accessed
at ref 30.
article_processing_charge: No
author:
- first_name: Soraya
full_name: Caixeiro, Soraya
last_name: Caixeiro
- first_name: Matilda
full_name: Peruzzo, Matilda
id: 3F920B30-F248-11E8-B48F-1D18A9856A87
last_name: Peruzzo
orcid: 0000-0002-3415-4628
- first_name: Olimpia
full_name: Onelli, Olimpia
last_name: Onelli
- first_name: Silvia
full_name: Vignolini, Silvia
last_name: Vignolini
- first_name: Riccardo
full_name: Sapienza, Riccardo
last_name: Sapienza
citation:
ama: Caixeiro S, Peruzzo M, Onelli O, Vignolini S, Sapienza R. Disordered cellulose
based nanostructures for enhanced light scattering. ACS Applied Materials and
Interfaces. 2017;9(9):7885-7890. doi:10.1021/acsami.6b15986
apa: Caixeiro, S., Peruzzo, M., Onelli, O., Vignolini, S., & Sapienza, R. (2017).
Disordered cellulose based nanostructures for enhanced light scattering. ACS
Applied Materials and Interfaces. American Chemical Society. https://doi.org/10.1021/acsami.6b15986
chicago: Caixeiro, Soraya, Matilda Peruzzo, Olimpia Onelli, Silvia Vignolini, and
Riccardo Sapienza. “Disordered Cellulose Based Nanostructures for Enhanced Light
Scattering.” ACS Applied Materials and Interfaces. American Chemical Society,
2017. https://doi.org/10.1021/acsami.6b15986.
ieee: S. Caixeiro, M. Peruzzo, O. Onelli, S. Vignolini, and R. Sapienza, “Disordered
cellulose based nanostructures for enhanced light scattering,” ACS Applied
Materials and Interfaces, vol. 9, no. 9. American Chemical Society, pp. 7885–7890,
2017.
ista: Caixeiro S, Peruzzo M, Onelli O, Vignolini S, Sapienza R. 2017. Disordered
cellulose based nanostructures for enhanced light scattering. ACS Applied Materials
and Interfaces. 9(9), 7885–7890.
mla: Caixeiro, Soraya, et al. “Disordered Cellulose Based Nanostructures for Enhanced
Light Scattering.” ACS Applied Materials and Interfaces, vol. 9, no. 9,
American Chemical Society, 2017, pp. 7885–90, doi:10.1021/acsami.6b15986.
short: S. Caixeiro, M. Peruzzo, O. Onelli, S. Vignolini, R. Sapienza, ACS Applied
Materials and Interfaces 9 (2017) 7885–7890.
date_created: 2018-12-11T11:49:44Z
date_published: 2017-03-08T00:00:00Z
date_updated: 2023-09-22T09:40:14Z
day: '08'
department:
- _id: JoFi
doi: 10.1021/acsami.6b15986
external_id:
isi:
- '000396186000002'
intvolume: ' 9'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1702.01415
month: '03'
oa: 1
oa_version: Submitted Version
page: 7885 - 7890
publication: ACS Applied Materials and Interfaces
publication_identifier:
issn:
- '19448244'
publication_status: published
publisher: American Chemical Society
publist_id: '6372'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Disordered cellulose based nanostructures for enhanced light scattering
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2017'
...
---
_id: '1021'
abstract:
- lang: eng
text: Most flows in nature and engineering are turbulent because of their large
velocities and spatial scales. Laboratory experiments on rotating quasi-Keplerian
flows, for which the angular velocity decreases radially but the angular momentum
increases, are however laminar at Reynolds numbers exceeding one million. This
is in apparent contradiction to direct numerical simulations showing that in these
experiments turbulence transition is triggered by the axial boundaries. We here
show numerically that as the Reynolds number increases, turbulence becomes progressively
confined to the boundary layers and the flow in the bulk fully relaminarizes.
Our findings support that turbulence is unlikely to occur in isothermal constant-density
quasi-Keplerian flows.
article_processing_charge: No
author:
- first_name: Jose M
full_name: Lopez Alonso, Jose M
id: 40770848-F248-11E8-B48F-1D18A9856A87
last_name: Lopez Alonso
orcid: 0000-0002-0384-2022
- first_name: Marc
full_name: Avila, Marc
last_name: Avila
citation:
ama: Lopez Alonso JM, Avila M. Boundary layer turbulence in experiments on quasi
Keplerian flows. Journal of Fluid Mechanics. 2017;817:21-34. doi:10.1017/jfm.2017.109
apa: Lopez Alonso, J. M., & Avila, M. (2017). Boundary layer turbulence in experiments
on quasi Keplerian flows. Journal of Fluid Mechanics. Cambridge University
Press. https://doi.org/10.1017/jfm.2017.109
chicago: Lopez Alonso, Jose M, and Marc Avila. “Boundary Layer Turbulence in Experiments
on Quasi Keplerian Flows.” Journal of Fluid Mechanics. Cambridge University
Press, 2017. https://doi.org/10.1017/jfm.2017.109.
ieee: J. M. Lopez Alonso and M. Avila, “Boundary layer turbulence in experiments
on quasi Keplerian flows,” Journal of Fluid Mechanics, vol. 817. Cambridge
University Press, pp. 21–34, 2017.
ista: Lopez Alonso JM, Avila M. 2017. Boundary layer turbulence in experiments on
quasi Keplerian flows. Journal of Fluid Mechanics. 817, 21–34.
mla: Lopez Alonso, Jose M., and Marc Avila. “Boundary Layer Turbulence in Experiments
on Quasi Keplerian Flows.” Journal of Fluid Mechanics, vol. 817, Cambridge
University Press, 2017, pp. 21–34, doi:10.1017/jfm.2017.109.
short: J.M. Lopez Alonso, M. Avila, Journal of Fluid Mechanics 817 (2017) 21–34.
date_created: 2018-12-11T11:49:44Z
date_published: 2017-04-25T00:00:00Z
date_updated: 2023-09-22T09:39:46Z
day: '25'
department:
- _id: BjHo
doi: 10.1017/jfm.2017.109
external_id:
isi:
- '000398179100006'
intvolume: ' 817'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1608.05527
month: '04'
oa: 1
oa_version: Submitted Version
page: 21 - 34
project:
- _id: 255008E4-B435-11E9-9278-68D0E5697425
grant_number: RGP0065/2012
name: Information processing and computation in fish groups
publication: Journal of Fluid Mechanics
publication_identifier:
issn:
- '00221120'
publication_status: published
publisher: Cambridge University Press
publist_id: '6371'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Boundary layer turbulence in experiments on quasi Keplerian flows
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 817
year: '2017'
...
---
_id: '1022'
abstract:
- lang: eng
text: We introduce a multiscale topological description of the Megaparsec web-like
cosmic matter distribution. Betti numbers and topological persistence offer a
powerful means of describing the rich connectivity structure of the cosmic web
and of its multiscale arrangement of matter and galaxies. Emanating from algebraic
topology and Morse theory, Betti numbers and persistence diagrams represent an
extension and deepening of the cosmologically familiar topological genus measure
and the related geometric Minkowski functionals. In addition to a description
of the mathematical background, this study presents the computational procedure
for computing Betti numbers and persistence diagrams for density field filtrations.
The field may be computed starting from a discrete spatial distribution of galaxies
or simulation particles. The main emphasis of this study concerns an extensive
and systematic exploration of the imprint of different web-like morphologies and
different levels of multiscale clustering in the corresponding computed Betti
numbers and persistence diagrams. To this end, we use Voronoi clustering models
as templates for a rich variety of web-like configurations and the fractal-like
Soneira-Peebles models exemplify a range of multiscale configurations. We have
identified the clear imprint of cluster nodes, filaments, walls, and voids in
persistence diagrams, along with that of the nested hierarchy of structures in
multiscale point distributions. We conclude by outlining the potential of persistent
topology for understanding the connectivity structure of the cosmic web, in large
simulations of cosmic structure formation and in the challenging context of the
observed galaxy distribution in large galaxy surveys.
acknowledgement: Part of this work has been supported by the 7th Framework Programme
for Research of the European Commission, under FETOpen grant number 255827 (CGL
Computational Geometry Learning) and ERC advanced grant, URSAT (Understanding Random
Systems via Algebraic Topology) number 320422.
article_processing_charge: No
author:
- first_name: Pratyush
full_name: Pranav, Pratyush
last_name: Pranav
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Rien
full_name: Van De Weygaert, Rien
last_name: Van De Weygaert
- first_name: Gert
full_name: Vegter, Gert
last_name: Vegter
- first_name: Michael
full_name: Kerber, Michael
last_name: Kerber
- first_name: Bernard
full_name: Jones, Bernard
last_name: Jones
- first_name: Mathijs
full_name: Wintraecken, Mathijs
id: 307CFBC8-F248-11E8-B48F-1D18A9856A87
last_name: Wintraecken
orcid: 0000-0002-7472-2220
citation:
ama: Pranav P, Edelsbrunner H, Van De Weygaert R, et al. The topology of the cosmic
web in terms of persistent Betti numbers. Monthly Notices of the Royal Astronomical
Society. 2017;465(4):4281-4310. doi:10.1093/mnras/stw2862
apa: Pranav, P., Edelsbrunner, H., Van De Weygaert, R., Vegter, G., Kerber, M.,
Jones, B., & Wintraecken, M. (2017). The topology of the cosmic web in terms
of persistent Betti numbers. Monthly Notices of the Royal Astronomical Society.
Oxford University Press. https://doi.org/10.1093/mnras/stw2862
chicago: Pranav, Pratyush, Herbert Edelsbrunner, Rien Van De Weygaert, Gert Vegter,
Michael Kerber, Bernard Jones, and Mathijs Wintraecken. “The Topology of the Cosmic
Web in Terms of Persistent Betti Numbers.” Monthly Notices of the Royal Astronomical
Society. Oxford University Press, 2017. https://doi.org/10.1093/mnras/stw2862.
ieee: P. Pranav et al., “The topology of the cosmic web in terms of persistent
Betti numbers,” Monthly Notices of the Royal Astronomical Society, vol.
465, no. 4. Oxford University Press, pp. 4281–4310, 2017.
ista: Pranav P, Edelsbrunner H, Van De Weygaert R, Vegter G, Kerber M, Jones B,
Wintraecken M. 2017. The topology of the cosmic web in terms of persistent Betti
numbers. Monthly Notices of the Royal Astronomical Society. 465(4), 4281–4310.
mla: Pranav, Pratyush, et al. “The Topology of the Cosmic Web in Terms of Persistent
Betti Numbers.” Monthly Notices of the Royal Astronomical Society, vol.
465, no. 4, Oxford University Press, 2017, pp. 4281–310, doi:10.1093/mnras/stw2862.
short: P. Pranav, H. Edelsbrunner, R. Van De Weygaert, G. Vegter, M. Kerber, B.
Jones, M. Wintraecken, Monthly Notices of the Royal Astronomical Society 465 (2017)
4281–4310.
date_created: 2018-12-11T11:49:44Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-09-22T09:40:55Z
day: '01'
department:
- _id: HeEd
doi: 10.1093/mnras/stw2862
external_id:
isi:
- '000395170200039'
intvolume: ' 465'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1608.04519
month: '01'
oa: 1
oa_version: Submitted Version
page: 4281 - 4310
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
issn:
- '00358711'
publication_status: published
publisher: Oxford University Press
publist_id: '6373'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The topology of the cosmic web in terms of persistent Betti numbers
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 465
year: '2017'
...
---
_id: '1023'
abstract:
- lang: eng
text: We consider products of independent square non-Hermitian random matrices.
More precisely, let X1,…, Xn be independent N × N random matrices with independent
entries (real or complex with independent real and imaginary parts) with zero
mean and variance 1/N. Soshnikov-O’Rourke [19] and Götze-Tikhomirov [15] showed
that the empirical spectral distribution of the product of n random matrices with
iid entries converges to (equation found). We prove that if the entries of the
matrices X1,…, Xn are independent (but not necessarily identically distributed)
and satisfy uniform subexponential decay condition, then in the bulk the convergence
of the ESD of X1,…, Xn to (0.1) holds up to the scale N–1/2+ε.
article_number: '22'
article_processing_charge: No
author:
- first_name: Yuriy
full_name: Nemish, Yuriy
id: 4D902E6A-F248-11E8-B48F-1D18A9856A87
last_name: Nemish
orcid: 0000-0002-7327-856X
citation:
ama: Nemish Y. Local law for the product of independent non-Hermitian random matrices
with independent entries. Electronic Journal of Probability. 2017;22. doi:10.1214/17-EJP38
apa: Nemish, Y. (2017). Local law for the product of independent non-Hermitian random
matrices with independent entries. Electronic Journal of Probability. Institute
of Mathematical Statistics. https://doi.org/10.1214/17-EJP38
chicago: Nemish, Yuriy. “Local Law for the Product of Independent Non-Hermitian
Random Matrices with Independent Entries.” Electronic Journal of Probability.
Institute of Mathematical Statistics, 2017. https://doi.org/10.1214/17-EJP38.
ieee: Y. Nemish, “Local law for the product of independent non-Hermitian random
matrices with independent entries,” Electronic Journal of Probability,
vol. 22. Institute of Mathematical Statistics, 2017.
ista: Nemish Y. 2017. Local law for the product of independent non-Hermitian random
matrices with independent entries. Electronic Journal of Probability. 22, 22.
mla: Nemish, Yuriy. “Local Law for the Product of Independent Non-Hermitian Random
Matrices with Independent Entries.” Electronic Journal of Probability,
vol. 22, 22, Institute of Mathematical Statistics, 2017, doi:10.1214/17-EJP38.
short: Y. Nemish, Electronic Journal of Probability 22 (2017).
date_created: 2018-12-11T11:49:44Z
date_published: 2017-02-06T00:00:00Z
date_updated: 2023-09-22T09:27:51Z
day: '06'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1214/17-EJP38
external_id:
isi:
- '000396611900022'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:29Z
date_updated: 2018-12-12T10:15:29Z
file_id: '5149'
file_name: IST-2017-802-v1+1_euclid.ejp.1487991681.pdf
file_size: 742275
relation: main_file
file_date_updated: 2018-12-12T10:15:29Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
publication: Electronic Journal of Probability
publication_identifier:
issn:
- '10836489'
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '6370'
pubrep_id: '802'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Local law for the product of independent non-Hermitian random matrices with
independent entries
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 22
year: '2017'
...
---
_id: '1024'
abstract:
- lang: eng
text: The history of auxin and cytokinin biology including the initial discoveries
by father–son duo Charles Darwin and Francis Darwin (1880), and Gottlieb Haberlandt
(1919) is a beautiful demonstration of unceasing continuity of research. Novel
findings are integrated into existing hypotheses and models and deepen our understanding
of biological principles. At the same time new questions are triggered and hand
to hand with this new methodologies are developed to address these new challenges.
alternative_title:
- Methods in Molecular Biology
author:
- first_name: Andrej
full_name: Hurny, Andrej
id: 4DC4AF46-F248-11E8-B48F-1D18A9856A87
last_name: Hurny
orcid: 0000-0003-3638-1426
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
citation:
ama: Hurny A, Benková E. Methodological advances in auxin and cytokinin biology.
Auxins and Cytokinins in Plant Biology. 2017;1569:1-29. doi:10.1007/978-1-4939-6831-2_1
apa: Hurny, A., & Benková, E. (2017). Methodological advances in auxin and cytokinin
biology. Auxins and Cytokinins in Plant Biology. Springer. https://doi.org/10.1007/978-1-4939-6831-2_1
chicago: Hurny, Andrej, and Eva Benková. “Methodological Advances in Auxin and Cytokinin
Biology.” Auxins and Cytokinins in Plant Biology. Springer, 2017. https://doi.org/10.1007/978-1-4939-6831-2_1.
ieee: A. Hurny and E. Benková, “Methodological advances in auxin and cytokinin biology,”
Auxins and Cytokinins in Plant Biology, vol. 1569. Springer, pp. 1–29,
2017.
ista: Hurny A, Benková E. 2017. Methodological advances in auxin and cytokinin biology.
Auxins and Cytokinins in Plant Biology. 1569, 1–29.
mla: Hurny, Andrej, and Eva Benková. “Methodological Advances in Auxin and Cytokinin
Biology.” Auxins and Cytokinins in Plant Biology, vol. 1569, Springer,
2017, pp. 1–29, doi:10.1007/978-1-4939-6831-2_1.
short: A. Hurny, E. Benková, Auxins and Cytokinins in Plant Biology 1569 (2017)
1–29.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-03-17T00:00:00Z
date_updated: 2024-03-25T23:30:09Z
day: '17'
ddc:
- '575'
department:
- _id: EvBe
doi: 10.1007/978-1-4939-6831-2_1
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:18Z
date_updated: 2019-10-15T07:47:05Z
file_id: '5068'
file_name: IST-2018-1019-v1+1_Hurny_MethodsMolBiol_2017.pdf
file_size: 840646
relation: main_file
file_date_updated: 2019-10-15T07:47:05Z
has_accepted_license: '1'
intvolume: ' 1569'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1 - 29
project:
- _id: 2542D156-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 1774-B16
name: Hormone cross-talk drives nutrient dependent plant development
publication: Auxins and Cytokinins in Plant Biology
publication_identifier:
issn:
- '10643745'
publication_status: published
publisher: Springer
publist_id: '6369'
pubrep_id: '1019'
quality_controlled: '1'
related_material:
record:
- id: '539'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Methodological advances in auxin and cytokinin biology
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1569
year: '2017'
...
---
_id: '1025'
abstract:
- lang: eng
text: Many organ surfaces are covered by a protective epithelial-cell layer. It
emerges that such layers are maintained by cell stretching that triggers cell
division mediated by the force-sensitive ion-channel protein Piezo1. See Letter
p.118
article_processing_charge: No
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Heisenberg C-PJ. Cell biology: Stretched divisions. Nature. 2017;543(7643):43-44.
doi:10.1038/nature21502'
apa: 'Heisenberg, C.-P. J. (2017). Cell biology: Stretched divisions. Nature.
Nature Publishing Group. https://doi.org/10.1038/nature21502'
chicago: 'Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature.
Nature Publishing Group, 2017. https://doi.org/10.1038/nature21502.'
ieee: 'C.-P. J. Heisenberg, “Cell biology: Stretched divisions,” Nature,
vol. 543, no. 7643. Nature Publishing Group, pp. 43–44, 2017.'
ista: 'Heisenberg C-PJ. 2017. Cell biology: Stretched divisions. Nature. 543(7643),
43–44.'
mla: 'Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature,
vol. 543, no. 7643, Nature Publishing Group, 2017, pp. 43–44, doi:10.1038/nature21502.'
short: C.-P.J. Heisenberg, Nature 543 (2017) 43–44.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-03-02T00:00:00Z
date_updated: 2023-09-22T09:26:59Z
day: '02'
department:
- _id: CaHe
doi: 10.1038/nature21502
external_id:
isi:
- '000395671500025'
intvolume: ' 543'
isi: 1
issue: '7643'
language:
- iso: eng
month: '03'
oa_version: None
page: 43 - 44
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Cell biology: Stretched divisions'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 543
year: '2017'
...
---
_id: '1026'
abstract:
- lang: eng
text: The optogenetic revolution enabled spatially-precise and temporally-precise
control over protein function, signaling pathway activation, and animal behavior
with tremendous success in the dissection of signaling networks and neural circuits.
Very recently, optogenetic methods have been paired with optical reporters in
novel drug screening platforms. In these all-optical platforms, light remotely
activated ion channels and kinases thereby obviating the use of electrophysiology
or reagents. Consequences were remarkable operational simplicity, throughput,
and cost-effectiveness that culminated in the identification of new drug candidates.
These blueprints for all-optical assays also revealed potential pitfalls and inspire
all-optical variants of other screens, such as those that aim at better understanding
dynamic drug action or orphan protein function.
acknowledgement: This work was supported by grants of the European Union Seventh Framework
Programme (CIG-303564), the Human Frontier Science Program (RGY0084_2012), and the
Austrian Science Fund FWF (W1232 MolecularDrugTargets).
article_processing_charge: No
article_type: original
author:
- first_name: Viviana
full_name: Agus, Viviana
last_name: Agus
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: 'Agus V, Janovjak HL. Optogenetic methods in drug screening: Technologies and
applications. Current Opinion in Biotechnology. 2017;48:8-14. doi:10.1016/j.copbio.2017.02.006'
apa: 'Agus, V., & Janovjak, H. L. (2017). Optogenetic methods in drug screening:
Technologies and applications. Current Opinion in Biotechnology. Elsevier.
https://doi.org/10.1016/j.copbio.2017.02.006'
chicago: 'Agus, Viviana, and Harald L Janovjak. “Optogenetic Methods in Drug Screening:
Technologies and Applications.” Current Opinion in Biotechnology. Elsevier,
2017. https://doi.org/10.1016/j.copbio.2017.02.006.'
ieee: 'V. Agus and H. L. Janovjak, “Optogenetic methods in drug screening: Technologies
and applications,” Current Opinion in Biotechnology, vol. 48. Elsevier,
pp. 8–14, 2017.'
ista: 'Agus V, Janovjak HL. 2017. Optogenetic methods in drug screening: Technologies
and applications. Current Opinion in Biotechnology. 48, 8–14.'
mla: 'Agus, Viviana, and Harald L. Janovjak. “Optogenetic Methods in Drug Screening:
Technologies and Applications.” Current Opinion in Biotechnology, vol.
48, Elsevier, 2017, pp. 8–14, doi:10.1016/j.copbio.2017.02.006.'
short: V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-22T09:26:06Z
day: '01'
department:
- _id: HaJa
doi: 10.1016/j.copbio.2017.02.006
ec_funded: 1
external_id:
isi:
- '000418313200003'
intvolume: ' 48'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
page: 8 - 14
project:
- _id: 255BFFFA-B435-11E9-9278-68D0E5697425
grant_number: RGY0084/2012
name: In situ real-time imaging of neurotransmitter signaling using designer optical
sensors (HFSP Young Investigator)
- _id: 25548C20-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303564'
name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 255A6082-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: Current Opinion in Biotechnology
publication_identifier:
issn:
- '09581669'
publication_status: published
publisher: Elsevier
publist_id: '6365'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Optogenetic methods in drug screening: Technologies and applications'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 48
year: '2017'
...
---
_id: '1027'
abstract:
- lang: eng
text: The rising prevalence of antibiotic resistant bacteria is an increasingly
serious public health challenge. To address this problem, recent work ranging
from clinical studies to theoretical modeling has provided valuable insights into
the mechanisms of resistance, its emergence and spread, and ways to counteract
it. A deeper understanding of the underlying dynamics of resistance evolution
will require a combination of experimental and theoretical expertise from different
disciplines and new technology for studying evolution in the laboratory. Here,
we review recent advances in the quantitative understanding of the mechanisms
and evolution of antibiotic resistance. We focus on key theoretical concepts and
new technology that enables well-controlled experiments. We further highlight
key challenges that can be met in the near future to ultimately develop effective
strategies for combating resistance.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Marta
full_name: Lukacisinova, Marta
id: 4342E402-F248-11E8-B48F-1D18A9856A87
last_name: Lukacisinova
orcid: 0000-0002-2519-8004
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Lukacisinova M, Bollenbach MT. Toward a quantitative understanding of antibiotic
resistance evolution. Current Opinion in Biotechnology. 2017;46:90-97.
doi:10.1016/j.copbio.2017.02.013
apa: Lukacisinova, M., & Bollenbach, M. T. (2017). Toward a quantitative understanding
of antibiotic resistance evolution. Current Opinion in Biotechnology. Elsevier.
https://doi.org/10.1016/j.copbio.2017.02.013
chicago: Lukacisinova, Marta, and Mark Tobias Bollenbach. “Toward a Quantitative
Understanding of Antibiotic Resistance Evolution.” Current Opinion in Biotechnology.
Elsevier, 2017. https://doi.org/10.1016/j.copbio.2017.02.013.
ieee: M. Lukacisinova and M. T. Bollenbach, “Toward a quantitative understanding
of antibiotic resistance evolution,” Current Opinion in Biotechnology,
vol. 46. Elsevier, pp. 90–97, 2017.
ista: Lukacisinova M, Bollenbach MT. 2017. Toward a quantitative understanding of
antibiotic resistance evolution. Current Opinion in Biotechnology. 46, 90–97.
mla: Lukacisinova, Marta, and Mark Tobias Bollenbach. “Toward a Quantitative Understanding
of Antibiotic Resistance Evolution.” Current Opinion in Biotechnology,
vol. 46, Elsevier, 2017, pp. 90–97, doi:10.1016/j.copbio.2017.02.013.
short: M. Lukacisinova, M.T. Bollenbach, Current Opinion in Biotechnology 46 (2017)
90–97.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2024-03-25T23:30:15Z
day: '01'
ddc:
- '570'
department:
- _id: ToBo
doi: 10.1016/j.copbio.2017.02.013
ec_funded: 1
external_id:
isi:
- '000408077400015'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2019-01-18T09:57:57Z
date_updated: 2019-01-18T09:57:57Z
file_id: '5846'
file_name: 2017_CurrentOpinion_Lukaciinova.pdf
file_size: 858338
relation: main_file
success: 1
file_date_updated: 2019-01-18T09:57:57Z
has_accepted_license: '1'
intvolume: ' 46'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 90 - 97
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
- _id: 25E83C2C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303507'
name: Optimality principles in responses to antibiotics
- _id: 25EB3A80-B435-11E9-9278-68D0E5697425
grant_number: RGP0042/2013
name: Revealing the fundamental limits of cell growth
publication: Current Opinion in Biotechnology
publication_status: published
publisher: Elsevier
publist_id: '6364'
pubrep_id: '801'
quality_controlled: '1'
related_material:
record:
- id: '6263'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Toward a quantitative understanding of antibiotic resistance evolution
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 46
year: '2017'
...
---
_id: '1028'
abstract:
- lang: eng
text: Optogenetics and photopharmacology provide spatiotemporally precise control
over protein interactions and protein function in cells and animals. Optogenetic
methods that are sensitive to green light and can be used to break protein complexes
are not broadly available but would enable multichromatic experiments with previously
inaccessible biological targets. Herein, we repurposed cobalamin (vitamin B12)
binding domains of bacterial CarH transcription factors for green-light-induced
receptor dissociation. In cultured cells, we observed oligomerization-induced
cell signaling for the fibroblast growth factor receptor 1 fused to cobalamin-binding
domains in the dark that was rapidly eliminated upon illumination. In zebrafish
embryos expressing fusion receptors, green light endowed control over aberrant
fibroblast growth factor signaling during development. Green-light-induced domain
dissociation and light-inactivated receptors will critically expand the optogenetic
toolbox for control of biological processes.
acknowledgement: "This work was supported by a grant from the European Union\U0010FC1Ds
Seventh Framework Programme (CIG-303564). E.R. was supported by the graduate program
MolecularDrugTargets (Austrian Science Fund (FWF), W1232) and a FemTech fellowship
(Austrian Research Promotion Agency, 3580812)"
article_processing_charge: No
author:
- first_name: Stephanie
full_name: Kainrath, Stephanie
id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
last_name: Kainrath
- first_name: Manuela
full_name: Stadler, Manuela
last_name: Stadler
- first_name: Eva
full_name: Gschaider-Reichhart, Eva
id: 3FEE232A-F248-11E8-B48F-1D18A9856A87
last_name: Gschaider-Reichhart
orcid: 0000-0002-7218-7738
- first_name: Martin
full_name: Distel, Martin
last_name: Distel
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Green-light-induced
inactivation of receptor signaling using cobalamin-binding domains. Angewandte
Chemie - International Edition. 2017;56(16):4608-4611. doi:10.1002/anie.201611998
apa: Kainrath, S., Stadler, M., Gschaider-Reichhart, E., Distel, M., & Janovjak,
H. L. (2017). Green-light-induced inactivation of receptor signaling using cobalamin-binding
domains. Angewandte Chemie - International Edition. Wiley-Blackwell. https://doi.org/10.1002/anie.201611998
chicago: Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel,
and Harald L Janovjak. “Green-Light-Induced Inactivation of Receptor Signaling
Using Cobalamin-Binding Domains.” Angewandte Chemie - International Edition.
Wiley-Blackwell, 2017. https://doi.org/10.1002/anie.201611998.
ieee: S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak,
“Green-light-induced inactivation of receptor signaling using cobalamin-binding
domains,” Angewandte Chemie - International Edition, vol. 56, no. 16. Wiley-Blackwell,
pp. 4608–4611, 2017.
ista: Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. 2017.
Green-light-induced inactivation of receptor signaling using cobalamin-binding
domains. Angewandte Chemie - International Edition. 56(16), 4608–4611.
mla: Kainrath, Stephanie, et al. “Green-Light-Induced Inactivation of Receptor Signaling
Using Cobalamin-Binding Domains.” Angewandte Chemie - International Edition,
vol. 56, no. 16, Wiley-Blackwell, 2017, pp. 4608–11, doi:10.1002/anie.201611998.
short: S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak,
Angewandte Chemie - International Edition 56 (2017) 4608–4611.
date_created: 2018-12-11T11:49:46Z
date_published: 2017-03-20T00:00:00Z
date_updated: 2024-03-25T23:30:08Z
day: '20'
ddc:
- '540'
department:
- _id: CaGu
- _id: HaJa
doi: 10.1002/anie.201611998
ec_funded: 1
external_id:
isi:
- '000398154000038'
file:
- access_level: open_access
content_type: application/pdf
creator: dernst
date_created: 2019-01-18T09:39:55Z
date_updated: 2019-01-18T09:39:55Z
file_id: '5845'
file_name: 2017_communications_Kainrath.pdf
file_size: 2614942
relation: main_file
success: 1
file_date_updated: 2019-01-18T09:39:55Z
has_accepted_license: '1'
intvolume: ' 56'
isi: 1
issue: '16'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 4608-4611
project:
- _id: 25548C20-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303564'
name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets [do not use to be deleted]
publication: Angewandte Chemie - International Edition
publication_identifier:
issn:
- '14337851'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6362'
quality_controlled: '1'
related_material:
record:
- id: '418'
relation: dissertation_contains
status: public
- id: '7680'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Green-light-induced inactivation of receptor signaling using cobalamin-binding
domains
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 56
year: '2017'
...
---
_id: '1029'
abstract:
- lang: eng
text: RNA Polymerase II pauses and backtracks during transcription, with many consequences
for gene expression and cellular physiology. Here, we show that the energy required
to melt double-stranded nucleic acids in the transcription bubble predicts pausing
in Saccharomyces cerevisiae far more accurately than nucleosome roadblocks do.
In addition, the same energy difference also determines when the RNA polymerase
backtracks instead of continuing to move forward. This data-driven model corroborates—in
a genome wide and quantitative manner—previous evidence that sequence-dependent
thermodynamic features of nucleic acids influence both transcriptional pausing
and backtracking.
article_number: e0174066
article_processing_charge: Yes
author:
- first_name: Martin
full_name: Lukacisin, Martin
id: 298FFE8C-F248-11E8-B48F-1D18A9856A87
last_name: Lukacisin
orcid: 0000-0001-6549-4177
- first_name: Matthieu
full_name: Landon, Matthieu
last_name: Landon
- first_name: Rishi
full_name: Jajoo, Rishi
last_name: Jajoo
citation:
ama: Lukacisin M, Landon M, Jajoo R. Sequence-specific thermodynamic properties
of nucleic acids influence both transcriptional pausing and backtracking in yeast.
PLoS One. 2017;12(3). doi:10.1371/journal.pone.0174066
apa: Lukacisin, M., Landon, M., & Jajoo, R. (2017). Sequence-specific thermodynamic
properties of nucleic acids influence both transcriptional pausing and backtracking
in yeast. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0174066
chicago: Lukacisin, Martin, Matthieu Landon, and Rishi Jajoo. “Sequence-Specific
Thermodynamic Properties of Nucleic Acids Influence Both Transcriptional Pausing
and Backtracking in Yeast.” PLoS One. Public Library of Science, 2017.
https://doi.org/10.1371/journal.pone.0174066.
ieee: M. Lukacisin, M. Landon, and R. Jajoo, “Sequence-specific thermodynamic properties
of nucleic acids influence both transcriptional pausing and backtracking in yeast,”
PLoS One, vol. 12, no. 3. Public Library of Science, 2017.
ista: Lukacisin M, Landon M, Jajoo R. 2017. Sequence-specific thermodynamic properties
of nucleic acids influence both transcriptional pausing and backtracking in yeast.
PLoS One. 12(3), e0174066.
mla: Lukacisin, Martin, et al. “Sequence-Specific Thermodynamic Properties of Nucleic
Acids Influence Both Transcriptional Pausing and Backtracking in Yeast.” PLoS
One, vol. 12, no. 3, e0174066, Public Library of Science, 2017, doi:10.1371/journal.pone.0174066.
short: M. Lukacisin, M. Landon, R. Jajoo, PLoS One 12 (2017).
date_created: 2018-12-11T11:49:46Z
date_published: 2017-03-16T00:00:00Z
date_updated: 2024-03-25T23:30:03Z
day: '16'
ddc:
- '570'
department:
- _id: ToBo
doi: 10.1371/journal.pone.0174066
external_id:
isi:
- '000396318300121'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:47Z
date_updated: 2018-12-12T10:09:47Z
file_id: '4772'
file_name: IST-2017-800-v1+1_journal.pone.0174066.pdf
file_size: 3429381
relation: main_file
file_date_updated: 2018-12-12T10:09:47Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_identifier:
issn:
- '19326203'
publication_status: published
publisher: Public Library of Science
publist_id: '6361'
pubrep_id: '800'
quality_controlled: '1'
related_material:
record:
- id: '5556'
relation: popular_science
status: public
- id: '6392'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Sequence-specific thermodynamic properties of nucleic acids influence both
transcriptional pausing and backtracking in yeast
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 12
year: '2017'
...
---
_id: '103'
abstract:
- lang: eng
text: We investigate effects of quasiparticle poisoning in a Majorana island with
strong tunnel coupling to normal-metal leads. In addition to the main Coulomb
blockade diamonds, "shadow" diamonds appear, shifted by 1e in gate voltage,
consistent with transport through an excited (poisoned) state of the island. Comparison
to a simple model yields an estimate of parity lifetime for the strongly coupled
island (∼1 μs) and sets a bound for a weakly coupled island (>10 μs). Fluctuations
in the gate-voltage spacing of Coulomb peaks at high field, reflecting Majorana
hybridization, are enhanced by the reduced lever arm at strong coupling. When
converted from gate voltage to energy units, fluctuations are consistent with
previous measurements.
acknowledgement: Research supported by Microsoft, the Danish National Research Foundation,
the Lundbeck Foundation, Carlsberg Foundation, Villum Foundation, and the European
Commission.
article_number: '137701'
arxiv: 1
author:
- first_name: S M
full_name: Albrecht, S M
last_name: Albrecht
- first_name: Esben
full_name: Hansen, Esben
last_name: Hansen
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
- first_name: Ferdinand
full_name: Kuemmeth, Ferdinand
last_name: Kuemmeth
- first_name: Thomas
full_name: Jespersen, Thomas
last_name: Jespersen
- first_name: Jesper
full_name: Nygård, Jesper
last_name: Nygård
- first_name: Peter
full_name: Krogstrup, Peter
last_name: Krogstrup
- first_name: Jeroen
full_name: Danon, Jeroen
last_name: Danon
- first_name: Karsten
full_name: Flensberg, Karsten
last_name: Flensberg
- first_name: Charles
full_name: Marcus, Charles
last_name: Marcus
citation:
ama: Albrecht SM, Hansen E, Higginbotham AP, et al. Transport signatures of quasiparticle
poisoning in a majorana island. APS Physics, Physical Review Letters. 2017;118(13).
doi:10.1103/PhysRevLett.118.137701
apa: Albrecht, S. M., Hansen, E., Higginbotham, A. P., Kuemmeth, F., Jespersen,
T., Nygård, J., … Marcus, C. (2017). Transport signatures of quasiparticle poisoning
in a majorana island. APS Physics, Physical Review Letters. American Physical
Society. https://doi.org/10.1103/PhysRevLett.118.137701
chicago: Albrecht, S M, Esben Hansen, Andrew P Higginbotham, Ferdinand Kuemmeth,
Thomas Jespersen, Jesper Nygård, Peter Krogstrup, Jeroen Danon, Karsten Flensberg,
and Charles Marcus. “Transport Signatures of Quasiparticle Poisoning in a Majorana
Island.” APS Physics, Physical Review Letters. American Physical Society,
2017. https://doi.org/10.1103/PhysRevLett.118.137701.
ieee: S. M. Albrecht et al., “Transport signatures of quasiparticle poisoning
in a majorana island,” APS Physics, Physical Review Letters, vol. 118,
no. 13. American Physical Society, 2017.
ista: Albrecht SM, Hansen E, Higginbotham AP, Kuemmeth F, Jespersen T, Nygård J,
Krogstrup P, Danon J, Flensberg K, Marcus C. 2017. Transport signatures of quasiparticle
poisoning in a majorana island. APS Physics, Physical Review Letters. 118(13),
137701.
mla: Albrecht, S. M., et al. “Transport Signatures of Quasiparticle Poisoning in
a Majorana Island.” APS Physics, Physical Review Letters, vol. 118, no.
13, 137701, American Physical Society, 2017, doi:10.1103/PhysRevLett.118.137701.
short: S.M. Albrecht, E. Hansen, A.P. Higginbotham, F. Kuemmeth, T. Jespersen, J.
Nygård, P. Krogstrup, J. Danon, K. Flensberg, C. Marcus, APS Physics, Physical
Review Letters 118 (2017).
date_created: 2018-12-11T11:44:39Z
date_published: 2017-03-31T00:00:00Z
date_updated: 2021-01-12T06:47:47Z
day: '31'
doi: 10.1103/PhysRevLett.118.137701
extern: '1'
external_id:
arxiv:
- '1612.05748'
intvolume: ' 118'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1612.05748
month: '03'
oa: 1
oa_version: Preprint
publication: APS Physics, Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '7951'
quality_controlled: '1'
status: public
title: Transport signatures of quasiparticle poisoning in a majorana island
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 118
year: '2017'
...
---
_id: '1030'
abstract:
- lang: ger
text: Auf der Suche nach einem Bibliothekssystem entschied sich die Forschungseinrichtung
IST Austria im Jahr 2014 für das Open-Source-Produkt Koha. In einem ersten Schritt
wurden zunächst Grundfunktionen aktiviert um im Anschluss diverse zusätzliche
Tools zum Einsatz zu bringen. Die große Flexibilität des Systems erlaubt maßgeschneiderte
Lösungen für unterschiedlichste Institutionen. Trotz Herausforderungen kann die
Bibliothek auf eine erfolgreiche Implementierung zurückblicken.
- lang: eng
text: "IST Austria was looking for a new library system until 2014 when the research
institute decided\r\nto implement Koha. The library first activated basic functions
of the open-source product and\r\nthen brought additional tools into operation.
The high flexibility of the system allows customized\r\nsolutions for different
institutions. Although the library faced some challenges, it can now look\r\nback
on a successful implementation."
article_processing_charge: No
article_type: original
author:
- first_name: Márton
full_name: Villányi, Márton
id: 3FFCCD3A-F248-11E8-B48F-1D18A9856A87
last_name: Villányi
orcid: 0000-0001-8126-0426
citation:
ama: Villányi M. Ein freies Bibliothekssystem für wissenschaftliche Bibliotheken
– Werkstattbericht der IST Austria Library. Informationspraxis. 2017;3(1).
doi:10.11588/ip.2017.1.35227
apa: Villányi, M. (2017). Ein freies Bibliothekssystem für wissenschaftliche Bibliotheken
– Werkstattbericht der IST Austria Library. Informationspraxis. Verein
Informationspraxis . https://doi.org/10.11588/ip.2017.1.35227
chicago: Villányi, Márton. “Ein Freies Bibliothekssystem Für Wissenschaftliche Bibliotheken
– Werkstattbericht Der IST Austria Library.” Informationspraxis. Verein
Informationspraxis , 2017. https://doi.org/10.11588/ip.2017.1.35227.
ieee: M. Villányi, “Ein freies Bibliothekssystem für wissenschaftliche Bibliotheken
– Werkstattbericht der IST Austria Library,” Informationspraxis, vol. 3,
no. 1. Verein Informationspraxis , 2017.
ista: Villányi M. 2017. Ein freies Bibliothekssystem für wissenschaftliche Bibliotheken
– Werkstattbericht der IST Austria Library. Informationspraxis. 3(1).
mla: Villányi, Márton. “Ein Freies Bibliothekssystem Für Wissenschaftliche Bibliotheken
– Werkstattbericht Der IST Austria Library.” Informationspraxis, vol. 3,
no. 1, Verein Informationspraxis , 2017, doi:10.11588/ip.2017.1.35227.
short: M. Villányi, Informationspraxis 3 (2017).
date_created: 2018-12-11T11:49:46Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-10-18T07:49:29Z
day: '01'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.11588/ip.2017.1.35227
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:20Z
date_updated: 2018-12-12T10:08:20Z
file_id: '4680'
file_name: IST-2017-799-v1+1_35227-112025-1-PB.pdf
file_size: 201163
relation: main_file
file_date_updated: 2018-12-12T10:08:20Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
popular_science: '1'
publication: Informationspraxis
publication_identifier:
issn:
- 2297-3249
publication_status: published
publisher: 'Verein Informationspraxis '
publist_id: '6360'
pubrep_id: '799'
status: public
title: Ein freies Bibliothekssystem für wissenschaftliche Bibliotheken – Werkstattbericht
der IST Austria Library
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2017'
...
---
_id: '10369'
abstract:
- lang: eng
text: Biological membranes have a central role in mediating the organization of
membrane-curving proteins, a dynamic process that has proven to be challenging
to probe experimentally. Using atomic force microscopy, we capture the hierarchically
organized assemblies of Bin/amphiphysin/Rvs (BAR) proteins on supported lipid
membranes. Their structure reveals distinct long linear aggregates of proteins,
regularly spaced by up to 300 nm. Employing accurate free-energy calculations
from large-scale coarse-grained computer simulations, we found that the membrane
mediates the interaction among protein filaments as a combination of short- and
long-ranged interactions. The long-ranged component acts at strikingly long distances,
giving rise to a variety of micron-sized ordered patterns. This mechanism may
contribute to the long-ranged spatiotemporal control of membrane remodeling by
proteins in the cell.
acknowledgement: M.S. and G.A.V. acknowledge their research reported in this publication
as being supported by the National Institute of General Medical Sciences of the
National Institutes of Health under Award Number R01-GM063796. Computational resources
were provided to M.S. and G.A.V. by the National Science Foundation through XSEDE
(Grant TG-MCA94P017, supercomputers Stampede and Gordon), and also by the Blue Waters
computing project at the National Center for Supercomputing Applications (University
of Illinois at Urbana–Champaign, NSF Awards OCI-0725070 and ACI-1238993). A.Š. acknowledges
support from the Human Frontier Science Program and Royal Society. J.M.H. and K.Y.C.L.
acknowledge the support from the National Science Foundation (Grant MCB-1413613)
and the NSF-supported MRSEC program at the University of Chicago (Grant DMR-1420709).
We are grateful to Carsten Mim and Vinzenz Unger of Northwestern University for
generously providing us with the protein. We thank all the members of the Voth group
for fruitful discussions, especially John M. A. Grime.
article_processing_charge: No
article_type: original
author:
- first_name: Mijo
full_name: Simunovic, Mijo
last_name: Simunovic
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: J. Michael
full_name: Henderson, J. Michael
last_name: Henderson
- first_name: Ka Yee C.
full_name: Lee, Ka Yee C.
last_name: Lee
- first_name: Gregory A.
full_name: Voth, Gregory A.
last_name: Voth
citation:
ama: Simunovic M, Šarić A, Henderson JM, Lee KYC, Voth GA. Long-range organization
of membrane-curving proteins. ACS Central Science. 2017;3(12):1246-1253.
doi:10.1021/acscentsci.7b00392
apa: Simunovic, M., Šarić, A., Henderson, J. M., Lee, K. Y. C., & Voth, G. A.
(2017). Long-range organization of membrane-curving proteins. ACS Central Science.
American Chemical Society. https://doi.org/10.1021/acscentsci.7b00392
chicago: Simunovic, Mijo, Anđela Šarić, J. Michael Henderson, Ka Yee C. Lee, and
Gregory A. Voth. “Long-Range Organization of Membrane-Curving Proteins.” ACS
Central Science. American Chemical Society, 2017. https://doi.org/10.1021/acscentsci.7b00392.
ieee: M. Simunovic, A. Šarić, J. M. Henderson, K. Y. C. Lee, and G. A. Voth, “Long-range
organization of membrane-curving proteins,” ACS Central Science, vol. 3,
no. 12. American Chemical Society, pp. 1246–1253, 2017.
ista: Simunovic M, Šarić A, Henderson JM, Lee KYC, Voth GA. 2017. Long-range organization
of membrane-curving proteins. ACS Central Science. 3(12), 1246–1253.
mla: Simunovic, Mijo, et al. “Long-Range Organization of Membrane-Curving Proteins.”
ACS Central Science, vol. 3, no. 12, American Chemical Society, 2017, pp.
1246–53, doi:10.1021/acscentsci.7b00392.
short: M. Simunovic, A. Šarić, J.M. Henderson, K.Y.C. Lee, G.A. Voth, ACS Central
Science 3 (2017) 1246–1253.
date_created: 2021-11-29T08:49:50Z
date_published: 2017-11-21T00:00:00Z
date_updated: 2021-11-29T09:28:06Z
day: '21'
ddc:
- '540'
doi: 10.1021/acscentsci.7b00392
extern: '1'
external_id:
pmid:
- '29296664'
file:
- access_level: open_access
checksum: 1cf3e5e5342f2d728f47560acc3ec560
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-29T09:00:40Z
date_updated: 2021-11-29T09:00:40Z
file_id: '10371'
file_name: 2017_ACSCentSci_Simunovic.pdf
file_size: 2635263
relation: main_file
success: 1
file_date_updated: 2021-11-29T09:00:40Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '12'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubs.acs.org/doi/10.1021/acscentsci.7b00392
month: '11'
oa: 1
oa_version: Published Version
page: 1246-1253
pmid: 1
publication: ACS Central Science
publication_identifier:
eissn:
- 2374-7951
issn:
- 2374-7943
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Long-range organization of membrane-curving proteins
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 3
year: '2017'
...
---
_id: '10370'
abstract:
- lang: eng
text: Eukaryotic cells are densely packed with macromolecular complexes and intertwining
organelles, continually transported and reshaped. Intriguingly, organelles avoid
clashing and entangling with each other in such limited space. Mitochondria form
extensive networks constantly remodeled by fission and fusion. Here, we show that
mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of
mitochondria – via encounter with motile intracellular pathogens, via external
pressure applied by an atomic force microscope, or via cell migration across uneven
microsurfaces – results in the recruitment of the mitochondrial fission machinery,
and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria,
acts as a membrane-bound force sensor to recruit the fission machinery to mechanically
strained sites. Thus, mitochondria adapt to the environment by sensing and responding
to biomechanical cues. Our findings that mechanical triggers can be coupled to
biochemical responses in membrane dynamics may explain how organelles orderly
cohabit in the crowded cytoplasm.
article_number: e30292
article_processing_charge: No
article_type: original
author:
- first_name: Sebastian Carsten Johannes
full_name: Helle, Sebastian Carsten Johannes
last_name: Helle
- first_name: Qian
full_name: Feng, Qian
last_name: Feng
- first_name: Mathias J
full_name: Aebersold, Mathias J
last_name: Aebersold
- first_name: Luca
full_name: Hirt, Luca
last_name: Hirt
- first_name: Raphael R
full_name: Grüter, Raphael R
last_name: Grüter
- first_name: Afshin
full_name: Vahid, Afshin
last_name: Vahid
- first_name: Andrea
full_name: Sirianni, Andrea
last_name: Sirianni
- first_name: Serge
full_name: Mostowy, Serge
last_name: Mostowy
- first_name: Jess G
full_name: Snedeker, Jess G
last_name: Snedeker
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Timon
full_name: Idema, Timon
last_name: Idema
- first_name: Tomaso
full_name: Zambelli, Tomaso
last_name: Zambelli
- first_name: Benoît
full_name: Kornmann, Benoît
last_name: Kornmann
citation:
ama: Helle SCJ, Feng Q, Aebersold MJ, et al. Mechanical force induces mitochondrial
fission. eLife. 2017;6. doi:10.7554/elife.30292
apa: Helle, S. C. J., Feng, Q., Aebersold, M. J., Hirt, L., Grüter, R. R., Vahid,
A., … Kornmann, B. (2017). Mechanical force induces mitochondrial fission. ELife.
eLife Sciences Publications. https://doi.org/10.7554/elife.30292
chicago: Helle, Sebastian Carsten Johannes, Qian Feng, Mathias J Aebersold, Luca
Hirt, Raphael R Grüter, Afshin Vahid, Andrea Sirianni, et al. “Mechanical Force
Induces Mitochondrial Fission.” ELife. eLife Sciences Publications, 2017.
https://doi.org/10.7554/elife.30292.
ieee: S. C. J. Helle et al., “Mechanical force induces mitochondrial fission,”
eLife, vol. 6. eLife Sciences Publications, 2017.
ista: Helle SCJ, Feng Q, Aebersold MJ, Hirt L, Grüter RR, Vahid A, Sirianni A, Mostowy
S, Snedeker JG, Šarić A, Idema T, Zambelli T, Kornmann B. 2017. Mechanical force
induces mitochondrial fission. eLife. 6, e30292.
mla: Helle, Sebastian Carsten Johannes, et al. “Mechanical Force Induces Mitochondrial
Fission.” ELife, vol. 6, e30292, eLife Sciences Publications, 2017, doi:10.7554/elife.30292.
short: S.C.J. Helle, Q. Feng, M.J. Aebersold, L. Hirt, R.R. Grüter, A. Vahid, A.
Sirianni, S. Mostowy, J.G. Snedeker, A. Šarić, T. Idema, T. Zambelli, B. Kornmann,
ELife 6 (2017).
date_created: 2021-11-29T08:51:38Z
date_published: 2017-11-09T00:00:00Z
date_updated: 2021-11-29T09:28:14Z
day: '09'
ddc:
- '572'
doi: 10.7554/elife.30292
extern: '1'
external_id:
pmid:
- '29119945'
file:
- access_level: open_access
checksum: c35f42dcfb007f6d6c761a27e24c26d3
content_type: application/pdf
creator: cchlebak
date_created: 2021-11-29T09:07:41Z
date_updated: 2021-11-29T09:07:41Z
file_id: '10372'
file_name: 2017_eLife_Helle.pdf
file_size: 6120157
relation: main_file
success: 1
file_date_updated: 2021-11-29T09:07:41Z
has_accepted_license: '1'
intvolume: ' 6'
keyword:
- general immunology and microbiology
- general biochemistry
- genetics and molecular biology
- general medicine
- general neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://elifesciences.org/articles/30292
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanical force induces mitochondrial fission
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 6
year: '2017'
...
---
_id: '10373'
abstract:
- lang: eng
text: 'Electric charges are conserved. The same would be expected to hold for magnetic
charges, yet magnetic monopoles have never been observed. It is therefore surprising
that the laws of nonequilibrium thermodynamics, combined with Maxwell’s equations,
suggest that colloidal particles heated or cooled in certain polar or paramagnetic
solvents may behave as if they carry an electric/magnetic charge. Here, we present
numerical simulations that show that the field distribution around a pair of such
heated/cooled colloidal particles agrees quantitatively with the theoretical predictions
for a pair of oppositely charged electric or magnetic monopoles. However, in other
respects, the nonequilibrium colloidal particles do not behave as monopoles: They
cannot be moved by a homogeneous applied field. The numerical evidence for the
monopole-like fields around heated/cooled colloidal particles is crucial because
the experimental and numerical determination of forces between such colloidal
particles would be complicated by the presence of other effects, such as thermophoresis.'
acknowledgement: P.W. acknowledges many invaluable discussions with Martin Neumann,
Chao Zhang, Michiel Sprik, Aleks Reinhardt, Carl Pölking, and Tine Curk. We acknowledge
financial support from the Austrian Academy of Sciences through a doctoral (DOC)
fellowship (to P.W.), the Austrian Science Fund (FWF) within the Spezialforschungsbereich
Vienna Computational Materials Laboratory (Project F41) (C.D.), and the European
Union Early Training Network NANOTRANS (Grant 674979 to D. Frenkel). The results
presented here have been achieved in part using the Vienna Scientific Cluster.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Peter
full_name: Wirnsberger, Peter
last_name: Wirnsberger
- first_name: Domagoj
full_name: Fijan, Domagoj
last_name: Fijan
- first_name: Roger A.
full_name: Lightwood, Roger A.
last_name: Lightwood
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Christoph
full_name: Dellago, Christoph
last_name: Dellago
- first_name: Daan
full_name: Frenkel, Daan
last_name: Frenkel
citation:
ama: Wirnsberger P, Fijan D, Lightwood RA, Šarić A, Dellago C, Frenkel D. Numerical
evidence for thermally induced monopoles. Proceedings of the National Academy
of Sciences. 2017;114(19):4911-4914. doi:10.1073/pnas.1621494114
apa: Wirnsberger, P., Fijan, D., Lightwood, R. A., Šarić, A., Dellago, C., &
Frenkel, D. (2017). Numerical evidence for thermally induced monopoles. Proceedings
of the National Academy of Sciences. National Academy of Sciences. https://doi.org/10.1073/pnas.1621494114
chicago: Wirnsberger, Peter, Domagoj Fijan, Roger A. Lightwood, Anđela Šarić, Christoph
Dellago, and Daan Frenkel. “Numerical Evidence for Thermally Induced Monopoles.”
Proceedings of the National Academy of Sciences. National Academy of Sciences,
2017. https://doi.org/10.1073/pnas.1621494114.
ieee: P. Wirnsberger, D. Fijan, R. A. Lightwood, A. Šarić, C. Dellago, and D. Frenkel,
“Numerical evidence for thermally induced monopoles,” Proceedings of the National
Academy of Sciences, vol. 114, no. 19. National Academy of Sciences, pp. 4911–4914,
2017.
ista: Wirnsberger P, Fijan D, Lightwood RA, Šarić A, Dellago C, Frenkel D. 2017.
Numerical evidence for thermally induced monopoles. Proceedings of the National
Academy of Sciences. 114(19), 4911–4914.
mla: Wirnsberger, Peter, et al. “Numerical Evidence for Thermally Induced Monopoles.”
Proceedings of the National Academy of Sciences, vol. 114, no. 19, National
Academy of Sciences, 2017, pp. 4911–14, doi:10.1073/pnas.1621494114.
short: P. Wirnsberger, D. Fijan, R.A. Lightwood, A. Šarić, C. Dellago, D. Frenkel,
Proceedings of the National Academy of Sciences 114 (2017) 4911–4914.
date_created: 2021-11-29T09:28:24Z
date_published: 2017-04-24T00:00:00Z
date_updated: 2021-11-29T09:59:12Z
day: '24'
doi: 10.1073/pnas.1621494114
extern: '1'
external_id:
arxiv:
- '1610.06840'
pmid:
- '28439003'
intvolume: ' 114'
issue: '19'
keyword:
- multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.pnas.org/content/114/19/4911
month: '04'
oa: 1
oa_version: Published Version
page: 4911-4914
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Numerical evidence for thermally induced monopoles
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 114
year: '2017'
...