---
_id: '740'
abstract:
- lang: eng
text: 'Developments in bioengineering and molecular biology have introduced a palette
of genetically encoded probes for identification of specific cell populations
in electron microscopy. These probes can be targeted to distinct cellular compartments,
rendering them electron dense through a subsequent chemical reaction. These electron
densities strongly increase the local contrast in samples prepared for electron
microscopy, allowing three major advances in ultrastructural mapping of circuits:
genetic identification of circuit components, targeted imaging of regions of interest
and automated analysis of the tagged circuits. Together, the gains from these
advances can decrease the time required for the analysis of targeted circuit motifs
by over two orders of magnitude. These genetic encoded tags for electron microscopy
promise to simplify the analysis of circuit motifs and become a central tool for
structure‐function studies of synaptic connections in the brain. We review the
current state‐of‐the‐art with an emphasis on connectomics, the quantitative analysis
of neuronal structures and motifs.'
article_number: e288
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
citation:
ama: Shigemoto R, Jösch MA. The genetic encoded toolbox for electron microscopy
and connectomics. WIREs Developmental Biology. 2017;6(6). doi:10.1002/wdev.288
apa: Shigemoto, R., & Jösch, M. A. (2017). The genetic encoded toolbox for electron
microscopy and connectomics. WIREs Developmental Biology. Wiley-Blackwell.
https://doi.org/10.1002/wdev.288
chicago: Shigemoto, Ryuichi, and Maximilian A Jösch. “The Genetic Encoded Toolbox
for Electron Microscopy and Connectomics.” WIREs Developmental Biology.
Wiley-Blackwell, 2017. https://doi.org/10.1002/wdev.288.
ieee: R. Shigemoto and M. A. Jösch, “The genetic encoded toolbox for electron microscopy
and connectomics,” WIREs Developmental Biology, vol. 6, no. 6. Wiley-Blackwell,
2017.
ista: Shigemoto R, Jösch MA. 2017. The genetic encoded toolbox for electron microscopy
and connectomics. WIREs Developmental Biology. 6(6), e288.
mla: Shigemoto, Ryuichi, and Maximilian A. Jösch. “The Genetic Encoded Toolbox for
Electron Microscopy and Connectomics.” WIREs Developmental Biology, vol.
6, no. 6, e288, Wiley-Blackwell, 2017, doi:10.1002/wdev.288.
short: R. Shigemoto, M.A. Jösch, WIREs Developmental Biology 6 (2017).
date_created: 2018-12-11T11:48:15Z
date_published: 2017-08-11T00:00:00Z
date_updated: 2023-09-27T12:51:41Z
day: '11'
ddc:
- '570'
department:
- _id: RySh
- _id: MaJö
doi: 10.1002/wdev.288
external_id:
isi:
- '000412827400005'
pmid:
- '28800674'
file:
- access_level: open_access
checksum: a9370f27b1591773b7a0de299bc81c8c
content_type: application/pdf
creator: dernst
date_created: 2019-11-19T07:36:18Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7045'
file_name: 2017_WIREs_Shigemoto.pdf
file_size: 1647787
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '6'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: WIREs Developmental Biology
publication_identifier:
issn:
- '17597684'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6927'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The genetic encoded toolbox for electron microscopy and connectomics
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 6
year: '2017'
...
---
_id: '741'
abstract:
- lang: eng
text: We prove that a system of N fermions interacting with an additional particle
via point interactions is stable if the ratio of the mass of the additional particle
to the one of the fermions is larger than some critical m*. The value of m* is
independent of N and turns out to be less than 1. This fact has important implications
for the stability of the unitary Fermi gas. We also characterize the domain of
the Hamiltonian of this model, and establish the validity of the Tan relations
for all wave functions in the domain.
article_processing_charge: No
author:
- first_name: Thomas
full_name: Moser, Thomas
id: 2B5FC9A4-F248-11E8-B48F-1D18A9856A87
last_name: Moser
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Moser T, Seiringer R. Stability of a fermionic N+1 particle system with point
interactions. Communications in Mathematical Physics. 2017;356(1):329-355.
doi:10.1007/s00220-017-2980-0
apa: Moser, T., & Seiringer, R. (2017). Stability of a fermionic N+1 particle
system with point interactions. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s00220-017-2980-0
chicago: Moser, Thomas, and Robert Seiringer. “Stability of a Fermionic N+1 Particle
System with Point Interactions.” Communications in Mathematical Physics.
Springer, 2017. https://doi.org/10.1007/s00220-017-2980-0.
ieee: T. Moser and R. Seiringer, “Stability of a fermionic N+1 particle system with
point interactions,” Communications in Mathematical Physics, vol. 356,
no. 1. Springer, pp. 329–355, 2017.
ista: Moser T, Seiringer R. 2017. Stability of a fermionic N+1 particle system with
point interactions. Communications in Mathematical Physics. 356(1), 329–355.
mla: Moser, Thomas, and Robert Seiringer. “Stability of a Fermionic N+1 Particle
System with Point Interactions.” Communications in Mathematical Physics,
vol. 356, no. 1, Springer, 2017, pp. 329–55, doi:10.1007/s00220-017-2980-0.
short: T. Moser, R. Seiringer, Communications in Mathematical Physics 356 (2017)
329–355.
date_created: 2018-12-11T11:48:15Z
date_published: 2017-11-01T00:00:00Z
date_updated: 2023-09-27T12:34:15Z
day: '01'
ddc:
- '539'
department:
- _id: RoSe
doi: 10.1007/s00220-017-2980-0
ec_funded: 1
external_id:
isi:
- '000409821300010'
file:
- access_level: open_access
checksum: 0fd9435400f91e9b3c5346319a2d24e3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:50Z
date_updated: 2020-07-14T12:47:57Z
file_id: '4841'
file_name: IST-2017-880-v1+1_s00220-017-2980-0.pdf
file_size: 952639
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
intvolume: ' 356'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 329 - 355
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27533_N27
name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- '00103616'
publication_status: published
publisher: Springer
publist_id: '6926'
pubrep_id: '880'
quality_controlled: '1'
related_material:
record:
- id: '52'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Stability of a fermionic N+1 particle system with point interactions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 356
year: '2017'
...
---
_id: '743'
abstract:
- lang: eng
text: "This special issue of the Journal on Formal Methods in System Design is dedicated
to Prof. Helmut Veith, who unexpectedly passed away in March 2016. Helmut Veith
was a brilliant researcher, inspiring collaborator, passionate mentor, generous
friend, and valued member of the formal methods community. Helmut was not only
known for his numerous and influential contributions in the field of automated
verification (most prominently his work on Counterexample-Guided Abstraction Refinement
[1,2]), but also for his untiring and passionate efforts for the logic community:
he co-organized the Vienna Summer of Logic (an event comprising twelve conferences
and numerous workshops which attracted thousands of researchers from all over
the world), he initiated the Vienna Center for Logic and Algorithms (which promotes
international collaboration on logic and algorithms and organizes outreach events
such as the LogicLounge), and he coordinated the Doctoral Program on Logical Methods
in Computer Science at TU Wien (currently educating more than 40 doctoral students)
and a National Research Network on Rigorous Systems Engineering (uniting fifteen
researchers in Austria to address the challenge of building reliable and safe
computer\r\nsystems). With his enthusiasm and commitment, Helmut completely reshaped
the Austrian research landscape in the field of logic and verification in his
few years as a full professor at TU Wien."
article_processing_charge: No
author:
- first_name: Georg
full_name: Gottlob, Georg
last_name: Gottlob
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Georg
full_name: Weißenbacher, Georg
last_name: Weißenbacher
citation:
ama: Gottlob G, Henzinger TA, Weißenbacher G. Preface of the special issue in memoriam
Helmut Veith. Formal Methods in System Design. 2017;51(2):267-269. doi:10.1007/s10703-017-0307-6
apa: Gottlob, G., Henzinger, T. A., & Weißenbacher, G. (2017). Preface of the
special issue in memoriam Helmut Veith. Formal Methods in System Design.
Springer. https://doi.org/10.1007/s10703-017-0307-6
chicago: Gottlob, Georg, Thomas A Henzinger, and Georg Weißenbacher. “Preface of
the Special Issue in Memoriam Helmut Veith.” Formal Methods in System Design.
Springer, 2017. https://doi.org/10.1007/s10703-017-0307-6.
ieee: G. Gottlob, T. A. Henzinger, and G. Weißenbacher, “Preface of the special
issue in memoriam Helmut Veith,” Formal Methods in System Design, vol.
51, no. 2. Springer, pp. 267–269, 2017.
ista: Gottlob G, Henzinger TA, Weißenbacher G. 2017. Preface of the special issue
in memoriam Helmut Veith. Formal Methods in System Design. 51(2), 267–269.
mla: Gottlob, Georg, et al. “Preface of the Special Issue in Memoriam Helmut Veith.”
Formal Methods in System Design, vol. 51, no. 2, Springer, 2017, pp. 267–69,
doi:10.1007/s10703-017-0307-6.
short: G. Gottlob, T.A. Henzinger, G. Weißenbacher, Formal Methods in System Design
51 (2017) 267–269.
date_created: 2018-12-11T11:48:16Z
date_published: 2017-11-14T00:00:00Z
date_updated: 2023-09-27T12:29:29Z
day: '14'
department:
- _id: ToHe
doi: 10.1007/s10703-017-0307-6
external_id:
isi:
- '000415615600001'
intvolume: ' 51'
isi: 1
issue: '2'
language:
- iso: eng
month: '11'
oa_version: None
page: 267 - 269
publication: Formal Methods in System Design
publication_status: published
publisher: Springer
publist_id: '6924'
quality_controlled: '1'
status: public
title: Preface of the special issue in memoriam Helmut Veith
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 51
year: '2017'
...
---
_id: '744'
abstract:
- lang: eng
text: In evolutionary game theory interactions between individuals are often assumed
obligatory. However, in many real-life situations, individuals can decide to opt
out of an interaction depending on the information they have about the opponent.
We consider a simple evolutionary game theoretic model to study such a scenario,
where at each encounter between two individuals the type of the opponent (cooperator/defector)
is known with some probability, and where each individual either accepts or opts
out of the interaction. If the type of the opponent is unknown, a trustful individual
accepts the interaction, whereas a suspicious individual opts out of the interaction.
If either of the two individuals opt out both individuals remain without an interaction.
We show that in the prisoners dilemma optional interactions along with suspicious
behaviour facilitates the emergence of trustful cooperation.
article_processing_charge: No
article_type: original
author:
- first_name: Tadeas
full_name: Priklopil, Tadeas
id: 3C869AA0-F248-11E8-B48F-1D18A9856A87
last_name: Priklopil
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Priklopil T, Chatterjee K, Nowak M. Optional interactions and suspicious behaviour
facilitates trustful cooperation in prisoners dilemma. Journal of Theoretical
Biology. 2017;433:64-72. doi:10.1016/j.jtbi.2017.08.025
apa: Priklopil, T., Chatterjee, K., & Nowak, M. (2017). Optional interactions
and suspicious behaviour facilitates trustful cooperation in prisoners dilemma.
Journal of Theoretical Biology. Elsevier. https://doi.org/10.1016/j.jtbi.2017.08.025
chicago: Priklopil, Tadeas, Krishnendu Chatterjee, and Martin Nowak. “Optional Interactions
and Suspicious Behaviour Facilitates Trustful Cooperation in Prisoners Dilemma.”
Journal of Theoretical Biology. Elsevier, 2017. https://doi.org/10.1016/j.jtbi.2017.08.025.
ieee: T. Priklopil, K. Chatterjee, and M. Nowak, “Optional interactions and suspicious
behaviour facilitates trustful cooperation in prisoners dilemma,” Journal
of Theoretical Biology, vol. 433. Elsevier, pp. 64–72, 2017.
ista: Priklopil T, Chatterjee K, Nowak M. 2017. Optional interactions and suspicious
behaviour facilitates trustful cooperation in prisoners dilemma. Journal of Theoretical
Biology. 433, 64–72.
mla: Priklopil, Tadeas, et al. “Optional Interactions and Suspicious Behaviour Facilitates
Trustful Cooperation in Prisoners Dilemma.” Journal of Theoretical Biology,
vol. 433, Elsevier, 2017, pp. 64–72, doi:10.1016/j.jtbi.2017.08.025.
short: T. Priklopil, K. Chatterjee, M. Nowak, Journal of Theoretical Biology 433
(2017) 64–72.
date_created: 2018-12-11T11:48:16Z
date_published: 2017-11-21T00:00:00Z
date_updated: 2023-09-27T12:29:02Z
day: '21'
ddc:
- '000'
- '570'
department:
- _id: KrCh
doi: 10.1016/j.jtbi.2017.08.025
ec_funded: 1
external_id:
isi:
- '000412039800007'
pmid:
- '28867224'
file:
- access_level: open_access
checksum: 4b43af1615ebf1a861840cb03d8a320c
content_type: application/pdf
creator: dernst
date_created: 2019-11-19T07:57:39Z
date_updated: 2020-07-14T12:47:58Z
file_id: '7047'
file_name: 2017_JournTheoretBio_Priklopil.pdf
file_size: 537323
relation: main_file
file_date_updated: 2020-07-14T12:47:58Z
has_accepted_license: '1'
intvolume: ' 433'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 64 - 72
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: ' Journal of Theoretical Biology'
publication_identifier:
issn:
- '00225193'
publication_status: published
publisher: Elsevier
publist_id: '6923'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optional interactions and suspicious behaviour facilitates trustful cooperation
in prisoners dilemma
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 433
year: '2017'
...
---
_id: '745'
abstract:
- lang: eng
text: 'Fluid flows in nature and applications are frequently subject to periodic
velocity modulations. Surprisingly, even for the generic case of flow through
a straight pipe, there is little consensus regarding the influence of pulsation
on the transition threshold to turbulence: while most studies predict a monotonically
increasing threshold with pulsation frequency (i.e. Womersley number, ), others
observe a decreasing threshold for identical parameters and only observe an increasing
threshold at low . In the present study we apply recent advances in the understanding
of transition in steady shear flows to pulsating pipe flow. For moderate pulsation
amplitudes we find that the first instability encountered is subcritical (i.e.
requiring finite amplitude disturbances) and gives rise to localized patches of
turbulence (''puffs'') analogous to steady pipe flow. By monitoring the impact
of pulsation on the lifetime of turbulence we map the onset of turbulence in parameter
space. Transition in pulsatile flow can be separated into three regimes. At small
Womersley numbers the dynamics is dominated by the decay turbulence suffers during
the slower part of the cycle and hence transition is delayed significantly. As
shown in this regime thresholds closely agree with estimates based on a quasi-steady
flow assumption only taking puff decay rates into account. The transition point
predicted in the zero limit equals to the critical point for steady pipe flow
offset by the oscillation Reynolds number (i.e. the dimensionless oscillation
amplitude). In the high frequency limit on the other hand, puff lifetimes are
identical to those in steady pipe flow and hence the transition threshold appears
to be unaffected by flow pulsation. In the intermediate frequency regime the transition
threshold sharply drops (with increasing ) from the decay dominated (quasi-steady)
threshold to the steady pipe flow level.'
article_processing_charge: No
author:
- first_name: Duo
full_name: Xu, Duo
id: 3454D55E-F248-11E8-B48F-1D18A9856A87
last_name: Xu
- first_name: Sascha
full_name: Warnecke, Sascha
last_name: Warnecke
- first_name: Baofang
full_name: Song, Baofang
last_name: Song
- first_name: Xingyu
full_name: Ma, Xingyu
id: 34BADBA6-F248-11E8-B48F-1D18A9856A87
last_name: Ma
orcid: 0000-0002-0179-9737
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Xu D, Warnecke S, Song B, Ma X, Hof B. Transition to turbulence in pulsating
pipe flow. Journal of Fluid Mechanics. 2017;831:418-432. doi:10.1017/jfm.2017.620
apa: Xu, D., Warnecke, S., Song, B., Ma, X., & Hof, B. (2017). Transition to
turbulence in pulsating pipe flow. Journal of Fluid Mechanics. Cambridge
University Press. https://doi.org/10.1017/jfm.2017.620
chicago: Xu, Duo, Sascha Warnecke, Baofang Song, Xingyu Ma, and Björn Hof. “Transition
to Turbulence in Pulsating Pipe Flow.” Journal of Fluid Mechanics. Cambridge
University Press, 2017. https://doi.org/10.1017/jfm.2017.620.
ieee: D. Xu, S. Warnecke, B. Song, X. Ma, and B. Hof, “Transition to turbulence
in pulsating pipe flow,” Journal of Fluid Mechanics, vol. 831. Cambridge
University Press, pp. 418–432, 2017.
ista: Xu D, Warnecke S, Song B, Ma X, Hof B. 2017. Transition to turbulence in pulsating
pipe flow. Journal of Fluid Mechanics. 831, 418–432.
mla: Xu, Duo, et al. “Transition to Turbulence in Pulsating Pipe Flow.” Journal
of Fluid Mechanics, vol. 831, Cambridge University Press, 2017, pp. 418–32,
doi:10.1017/jfm.2017.620.
short: D. Xu, S. Warnecke, B. Song, X. Ma, B. Hof, Journal of Fluid Mechanics 831
(2017) 418–432.
date_created: 2018-12-11T11:48:17Z
date_published: 2017-11-25T00:00:00Z
date_updated: 2023-09-27T12:28:12Z
day: '25'
department:
- _id: BjHo
doi: 10.1017/jfm.2017.620
ec_funded: 1
external_id:
isi:
- '000412934800005'
intvolume: ' 831'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1709.03738
month: '11'
oa: 1
oa_version: Submitted Version
page: 418 - 432
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
publication: Journal of Fluid Mechanics
publication_identifier:
issn:
- '00221120'
publication_status: published
publisher: Cambridge University Press
publist_id: '6922'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Transition to turbulence in pulsating pipe flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 831
year: '2017'
...
---
_id: '746'
abstract:
- lang: eng
text: Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated
in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at
the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored.
Here, we probed the consequences of mGluR5/Homer scaffold disruption for mGluR5
cell-surface mobility, synaptic N-methyl-D-Aspartate receptor (NMDAR) function,
and behavioral phenotypes in the second-generation Fmr1 knockout (KO) mouse. Using
single-molecule tracking, we found that mGluR5 was significantly more mobile at
synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface
co-clustering of mGluR5 and NMDAR. This correlated with a reduced amplitude of
synaptic NMDAR currents, a lack of their mGluR5-Activated long-Term depression,
and NMDAR/hippocampus dependent cognitive deficits. These synaptic and behavioral
phenomena were reversed by knocking down Homer1a in Fmr1 KO mice. Our study provides
a mechanistic link between changes of mGluR5 dynamics and pathological phenotypes
of FXS, unveiling novel targets for mGluR5-based therapeutics.
article_number: '1103'
article_processing_charge: No
author:
- first_name: Elisabetta
full_name: Aloisi, Elisabetta
last_name: Aloisi
- first_name: Katy
full_name: Le Corf, Katy
last_name: Le Corf
- first_name: Julien
full_name: Dupuis, Julien
last_name: Dupuis
- first_name: Pei
full_name: Zhang, Pei
last_name: Zhang
- first_name: Melanie
full_name: Ginger, Melanie
last_name: Ginger
- first_name: Virginie
full_name: Labrousse, Virginie
last_name: Labrousse
- first_name: Michela
full_name: Spatuzza, Michela
last_name: Spatuzza
- first_name: Matthias
full_name: Georg Haberl, Matthias
last_name: Georg Haberl
- first_name: Lara
full_name: Costa, Lara
last_name: Costa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Anke
full_name: Tappe Theodor, Anke
last_name: Tappe Theodor
- first_name: Fillippo
full_name: Drago, Fillippo
last_name: Drago
- first_name: Pier
full_name: Vincenzo Piazza, Pier
last_name: Vincenzo Piazza
- first_name: Christophe
full_name: Mulle, Christophe
last_name: Mulle
- first_name: Laurent
full_name: Groc, Laurent
last_name: Groc
- first_name: Lucia
full_name: Ciranna, Lucia
last_name: Ciranna
- first_name: Maria
full_name: Catania, Maria
last_name: Catania
- first_name: Andreas
full_name: Frick, Andreas
last_name: Frick
citation:
ama: Aloisi E, Le Corf K, Dupuis J, et al. Altered surface mGluR5 dynamics provoke
synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature
Communications. 2017;8(1). doi:10.1038/s41467-017-01191-2
apa: Aloisi, E., Le Corf, K., Dupuis, J., Zhang, P., Ginger, M., Labrousse, V.,
… Frick, A. (2017). Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction
and cognitive defects in Fmr1 knockout mice. Nature Communications. Nature
Publishing Group. https://doi.org/10.1038/s41467-017-01191-2
chicago: Aloisi, Elisabetta, Katy Le Corf, Julien Dupuis, Pei Zhang, Melanie Ginger,
Virginie Labrousse, Michela Spatuzza, et al. “Altered Surface MGluR5 Dynamics
Provoke Synaptic NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.”
Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/s41467-017-01191-2.
ieee: E. Aloisi et al., “Altered surface mGluR5 dynamics provoke synaptic
NMDAR dysfunction and cognitive defects in Fmr1 knockout mice,” Nature Communications,
vol. 8, no. 1. Nature Publishing Group, 2017.
ista: Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, Spatuzza M,
Georg Haberl M, Costa L, Shigemoto R, Tappe Theodor A, Drago F, Vincenzo Piazza
P, Mulle C, Groc L, Ciranna L, Catania M, Frick A. 2017. Altered surface mGluR5
dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout
mice. Nature Communications. 8(1), 1103.
mla: Aloisi, Elisabetta, et al. “Altered Surface MGluR5 Dynamics Provoke Synaptic
NMDAR Dysfunction and Cognitive Defects in Fmr1 Knockout Mice.” Nature Communications,
vol. 8, no. 1, 1103, Nature Publishing Group, 2017, doi:10.1038/s41467-017-01191-2.
short: E. Aloisi, K. Le Corf, J. Dupuis, P. Zhang, M. Ginger, V. Labrousse, M. Spatuzza,
M. Georg Haberl, L. Costa, R. Shigemoto, A. Tappe Theodor, F. Drago, P. Vincenzo
Piazza, C. Mulle, L. Groc, L. Ciranna, M. Catania, A. Frick, Nature Communications
8 (2017).
date_created: 2018-12-11T11:48:17Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-27T12:27:30Z
day: '01'
ddc:
- '571'
department:
- _id: RySh
doi: 10.1038/s41467-017-01191-2
external_id:
isi:
- '000413571300004'
file:
- access_level: open_access
checksum: 99ceee57549dc0461e3adfc037ec70a9
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:32Z
date_updated: 2020-07-14T12:47:58Z
file_id: '5287'
file_name: IST-2017-915-v1+1_s41467-017-01191-2.pdf
file_size: 1841650
relation: main_file
file_date_updated: 2020-07-14T12:47:58Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6921'
pubrep_id: '915'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive
defects in Fmr1 knockout mice
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '747'
abstract:
- lang: eng
text: Bradykinin (BK), a component of the kallikrein-kininogen-kinin system exerts
multiple effects via B1 and B2 receptor activation. In the cardiovascular system,
bradykinin has cardioprotective and vasodilator properties. We investigated the
effect of BK on cardiac-projecting neurons of nucleus ambiguus, a key site for
the parasympathetic cardiac regulation. BK produced a dose-dependent increase
in cytosolic Ca2+ concentration. Pretreatment with HOE140, a B2 receptor antagonist,
but not with R715, a B1 receptor antagonist, abolished the response to BK. A selective
B2 receptor agonist, but not a B1 receptor agonist, elicited an increase in cytosolic
Ca2+ similarly to BK. Inhibition of N-type voltage-gated Ca2+ channels with ω-conotoxin
GVIA had no effect on the Ca2+ signal produced by BK, while pretreatment with
ω-conotoxin MVIIC, a blocker of P/Q-type of Ca2+ channels, significantly diminished
the effect of BK. Pretreatment with xestospongin C and 2-aminoethoxydiphenyl borate,
antagonists of inositol 1,4,5-trisphosphate receptors, abolished the response
to BK. Inhibition of ryanodine receptors reduced the BK-induced Ca2+ increase,
while disruption of lysosomal Ca2+ stores with bafilomycin A1 did not affect the
response. BK produced a dose-dependent depolarization of nucleus ambiguus neurons,
which was prevented by the B2 receptor antagonist. In vivo studies indicate that
microinjection of BK into nucleus ambiguus elicited bradycardia in conscious rats
via B2 receptors. In summary, in cardiac vagal neurons of nucleus ambiguus, BK
activates B2 receptors promoting Ca2+ influx and Ca2+ release from endoplasmic
reticulum, and membrane depolarization; these effects are translated in vivo by
bradycardia.
article_processing_charge: No
article_type: original
author:
- first_name: Eugen
full_name: Brǎiloiu, Eugen
last_name: Brǎiloiu
- first_name: Matthew
full_name: Mcguire, Matthew
last_name: Mcguire
- first_name: Shadaria
full_name: Shuler, Shadaria
last_name: Shuler
- first_name: Elena
full_name: Deliu, Elena
id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
last_name: Deliu
orcid: 0000-0002-7370-5293
- first_name: Jeffrey
full_name: Barr, Jeffrey
last_name: Barr
- first_name: Mary
full_name: Abood, Mary
last_name: Abood
- first_name: Gabriela
full_name: Brailoiu, Gabriela
last_name: Brailoiu
citation:
ama: Brǎiloiu E, Mcguire M, Shuler S, et al. Modulation of cardiac vagal tone by
bradykinin acting on nucleus ambiguus. Neuroscience. 2017;365:23-32. doi:10.1016/j.neuroscience.2017.09.034
apa: Brǎiloiu, E., Mcguire, M., Shuler, S., Deliu, E., Barr, J., Abood, M., &
Brailoiu, G. (2017). Modulation of cardiac vagal tone by bradykinin acting on
nucleus ambiguus. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2017.09.034
chicago: Brǎiloiu, Eugen, Matthew Mcguire, Shadaria Shuler, Elena Deliu, Jeffrey
Barr, Mary Abood, and Gabriela Brailoiu. “Modulation of Cardiac Vagal Tone by
Bradykinin Acting on Nucleus Ambiguus.” Neuroscience. Elsevier, 2017. https://doi.org/10.1016/j.neuroscience.2017.09.034.
ieee: E. Brǎiloiu et al., “Modulation of cardiac vagal tone by bradykinin
acting on nucleus ambiguus,” Neuroscience, vol. 365. Elsevier, pp. 23–32,
2017.
ista: Brǎiloiu E, Mcguire M, Shuler S, Deliu E, Barr J, Abood M, Brailoiu G. 2017.
Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience.
365, 23–32.
mla: Brǎiloiu, Eugen, et al. “Modulation of Cardiac Vagal Tone by Bradykinin Acting
on Nucleus Ambiguus.” Neuroscience, vol. 365, Elsevier, 2017, pp. 23–32,
doi:10.1016/j.neuroscience.2017.09.034.
short: E. Brǎiloiu, M. Mcguire, S. Shuler, E. Deliu, J. Barr, M. Abood, G. Brailoiu,
Neuroscience 365 (2017) 23–32.
date_created: 2018-12-11T11:48:17Z
date_published: 2017-12-04T00:00:00Z
date_updated: 2023-09-27T12:26:59Z
day: '04'
department:
- _id: GaNo
doi: 10.1016/j.neuroscience.2017.09.034
external_id:
isi:
- '000415966200003'
pmid:
- '28951324'
intvolume: ' 365'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798458
month: '12'
oa: 1
oa_version: Submitted Version
page: 23 - 32
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- '03064522'
publication_status: published
publisher: Elsevier
publist_id: '6911'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 365
year: '2017'
...
---
_id: '748'
abstract:
- lang: eng
text: The essay focuses on individual and collective forms of liminality in John
Marlyn’s Under the Ribs of Death. Set in early twentieth-century Winnipeg, the
1957 immigrant novel explores liminal experiences related to ethnic identity,
male sexuality, social class, urban spaces and turbulent economic times. As the
son of a poor working-class family from Hungary, Sandor Hunyadi makes every effort
to become a true Canadian and a successful businessman, but, no matter how hard
he tries to overcome contemporary ethnic prejudices and economic hardships, his
personal and professional life remains in liminality. In other words, the protagonist
undergoes separation, fails at incorporation, and becomes stuck in transition.
alternative_title:
- Canadiana
author:
- first_name: Bernhard
full_name: Bernhard Wenzl
id: 479E9046-F248-11E8-B48F-1D18A9856A87
last_name: Wenzl
citation:
ama: 'Wenzl B. “...beyond the invisible barrier at Portage and Main”: Liminality
in John Marlyn’s Under the Ribs of Death. In: Brandt S, ed. In-Between - Liminal
Spaces in Canadian Literature and Culture. Peter Lang GmbH; 2017:91-100. doi:10.3726/b11899'
apa: 'Wenzl, B. (2017). “...beyond the invisible barrier at Portage and Main”: Liminality
in John Marlyn’s Under the Ribs of Death. In S. Brandt (Ed.), In-Between -
Liminal Spaces in Canadian Literature and Culture (pp. 91–100). Peter Lang
GmbH. https://doi.org/10.3726/b11899'
chicago: 'Wenzl, Bernhard. “‘...Beyond the Invisible Barrier at Portage and Main’:
Liminality in John Marlyn’s Under the Ribs of Death.” In In-Between - Liminal
Spaces in Canadian Literature and Culture, edited by Stefan Brandt, 91–100.
Peter Lang GmbH, 2017. https://doi.org/10.3726/b11899.'
ieee: 'B. Wenzl, “‘...beyond the invisible barrier at Portage and Main’: Liminality
in John Marlyn’s Under the Ribs of Death,” in In-Between - Liminal Spaces in
Canadian Literature and Culture, S. Brandt, Ed. Peter Lang GmbH, 2017, pp.
91–100.'
ista: 'Wenzl B. 2017.‘...beyond the invisible barrier at Portage and Main’: Liminality
in John Marlyn’s Under the Ribs of Death. In: In-Between - Liminal Spaces in Canadian
Literature and Culture. Canadiana, , 91–100.'
mla: 'Wenzl, Bernhard. “‘...Beyond the Invisible Barrier at Portage and Main’: Liminality
in John Marlyn’s Under the Ribs of Death.” In-Between - Liminal Spaces in Canadian
Literature and Culture, edited by Stefan Brandt, Peter Lang GmbH, 2017, pp.
91–100, doi:10.3726/b11899.'
short: B. Wenzl, in:, S. Brandt (Ed.), In-Between - Liminal Spaces in Canadian Literature
and Culture, Peter Lang GmbH, 2017, pp. 91–100.
date_created: 2018-12-11T11:48:18Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2021-01-12T08:13:49Z
day: '01'
doi: 10.3726/b11899
editor:
- first_name: Stefan
full_name: Brandt, Stefan L.
last_name: Brandt
extern: 1
month: '12'
page: 91 - 100
publication: In-Between - Liminal Spaces in Canadian Literature and Culture
publication_status: published
publisher: Peter Lang GmbH
publist_id: '6909'
quality_controlled: 0
status: public
title: '''...beyond the invisible barrier at Portage and Main'': Liminality in John
Marlyn''s Under the Ribs of Death'
type: book_chapter
year: '2017'
...
---
_id: '749'
abstract:
- lang: eng
text: 'Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous
transmitter release and facilitation at synapses. However, Syt7 is strongly expressed
in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output
synapses of these neurons produce only minimal asynchronous release and show depression
rather than facilitation. To resolve this apparent contradiction, we examined
the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic
basket cell (BC)-Purkinje cell (PC) synapse in cerebellum. Our results indicate
that at the BC-PC synapse, Syt7 contributes to asynchronous release, pool replenishment,
and facilitation. In combination, these three effects ensure efficient transmitter
release during high-frequency activity and guarantee frequency independence of
inhibition. Our results identify a distinct function of Syt7: ensuring the efficiency
of high-frequency inhibitory synaptic transmission'
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Chong
full_name: Chen, Chong
id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Rachel
full_name: Satterfield, Rachel
last_name: Satterfield
- first_name: Samuel
full_name: Young, Samuel
last_name: Young
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Chen C, Satterfield R, Young S, Jonas PM. Triple function of Synaptotagmin
7 ensures efficiency of high-frequency transmission at central GABAergic synapses.
Cell Reports. 2017;21(8):2082-2089. doi:10.1016/j.celrep.2017.10.122
apa: Chen, C., Satterfield, R., Young, S., & Jonas, P. M. (2017). Triple function
of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central
GABAergic synapses. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2017.10.122
chicago: Chen, Chong, Rachel Satterfield, Samuel Young, and Peter M Jonas. “Triple
Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission
at Central GABAergic Synapses.” Cell Reports. Cell Press, 2017. https://doi.org/10.1016/j.celrep.2017.10.122.
ieee: C. Chen, R. Satterfield, S. Young, and P. M. Jonas, “Triple function of Synaptotagmin
7 ensures efficiency of high-frequency transmission at central GABAergic synapses,”
Cell Reports, vol. 21, no. 8. Cell Press, pp. 2082–2089, 2017.
ista: Chen C, Satterfield R, Young S, Jonas PM. 2017. Triple function of Synaptotagmin
7 ensures efficiency of high-frequency transmission at central GABAergic synapses.
Cell Reports. 21(8), 2082–2089.
mla: Chen, Chong, et al. “Triple Function of Synaptotagmin 7 Ensures Efficiency
of High-Frequency Transmission at Central GABAergic Synapses.” Cell Reports,
vol. 21, no. 8, Cell Press, 2017, pp. 2082–89, doi:10.1016/j.celrep.2017.10.122.
short: C. Chen, R. Satterfield, S. Young, P.M. Jonas, Cell Reports 21 (2017) 2082–2089.
date_created: 2018-12-11T11:48:18Z
date_published: 2017-11-21T00:00:00Z
date_updated: 2023-09-27T12:26:04Z
day: '21'
ddc:
- '570'
- '571'
department:
- _id: PeJo
doi: 10.1016/j.celrep.2017.10.122
ec_funded: 1
external_id:
isi:
- '000416216700007'
file:
- access_level: open_access
checksum: a6afa3764909bf6edafa07982d8e1cee
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:14Z
date_updated: 2020-07-14T12:47:59Z
file_id: '4737'
file_name: IST-2017-874-v1+1_PIIS2211124717316029.pdf
file_size: 2759195
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
issue: '8'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 2082 - 2089
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P24909-B24
name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
publication: Cell Reports
publication_identifier:
issn:
- '22111247'
publication_status: published
publisher: Cell Press
publist_id: '6907'
pubrep_id: '874'
quality_controlled: '1'
related_material:
record:
- id: '324'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission
at central GABAergic synapses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 21
year: '2017'
...
---
_id: '750'
abstract:
- lang: eng
text: Modern communication technologies allow first responders to contact thousands
of potential volunteers simultaneously for support during a crisis or disaster
event. However, such volunteer efforts must be well coordinated and monitored,
in order to offer an effective relief to the professionals. In this paper we extend
earlier work on optimally assigning volunteers to selected landmark locations.
In particular, we emphasize the aspect that obtaining good assignments requires
not only advanced computational tools, but also a realistic measure of distance
between volunteers and landmarks. Specifically, we propose the use of the Open
Street Map (OSM) driving distance instead of he previously used flight distance.
We find the OSM driving distance to be better aligned with the interests of volunteers
and first responders. Furthermore, we show that relying on the flying distance
leads to a substantial underestimation of the number of required volunteers, causing
negative side effects in case of an actual crisis situation.
author:
- first_name: Jasmin
full_name: Pielorz, Jasmin
id: 49BC895A-F248-11E8-B48F-1D18A9856A87
last_name: Pielorz
- first_name: Matthias
full_name: Prandtstetter, Matthias
last_name: Prandtstetter
- first_name: Markus
full_name: Straub, Markus
last_name: Straub
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Pielorz J, Prandtstetter M, Straub M, Lampert C. Optimal geospatial volunteer
allocation needs realistic distances. In: 2017 IEEE International Conference
on Big Data. IEEE; 2017:3760-3763. doi:10.1109/BigData.2017.8258375'
apa: 'Pielorz, J., Prandtstetter, M., Straub, M., & Lampert, C. (2017). Optimal
geospatial volunteer allocation needs realistic distances. In 2017 IEEE International
Conference on Big Data (pp. 3760–3763). Boston, MA, United States: IEEE. https://doi.org/10.1109/BigData.2017.8258375'
chicago: Pielorz, Jasmin, Matthias Prandtstetter, Markus Straub, and Christoph Lampert.
“Optimal Geospatial Volunteer Allocation Needs Realistic Distances.” In 2017
IEEE International Conference on Big Data, 3760–63. IEEE, 2017. https://doi.org/10.1109/BigData.2017.8258375.
ieee: J. Pielorz, M. Prandtstetter, M. Straub, and C. Lampert, “Optimal geospatial
volunteer allocation needs realistic distances,” in 2017 IEEE International
Conference on Big Data, Boston, MA, United States, 2017, pp. 3760–3763.
ista: Pielorz J, Prandtstetter M, Straub M, Lampert C. 2017. Optimal geospatial
volunteer allocation needs realistic distances. 2017 IEEE International Conference
on Big Data. Big Data, 3760–3763.
mla: Pielorz, Jasmin, et al. “Optimal Geospatial Volunteer Allocation Needs Realistic
Distances.” 2017 IEEE International Conference on Big Data, IEEE, 2017,
pp. 3760–63, doi:10.1109/BigData.2017.8258375.
short: J. Pielorz, M. Prandtstetter, M. Straub, C. Lampert, in:, 2017 IEEE International
Conference on Big Data, IEEE, 2017, pp. 3760–3763.
conference:
end_date: 2017-12-14
location: Boston, MA, United States
name: Big Data
start_date: 2017-12-11
date_created: 2018-12-11T11:48:18Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2021-01-12T08:13:55Z
day: '01'
department:
- _id: ChLa
doi: 10.1109/BigData.2017.8258375
language:
- iso: eng
month: '12'
oa_version: None
page: 3760 - 3763
publication: 2017 IEEE International Conference on Big Data
publication_identifier:
isbn:
- 978-153862714-3
publication_status: published
publisher: IEEE
publist_id: '6906'
quality_controlled: '1'
scopus_import: 1
status: public
title: Optimal geospatial volunteer allocation needs realistic distances
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '751'
abstract:
- lang: eng
text: The basement membrane (BM) is a thin layer of extracellular matrix (ECM) beneath
nearly all epithelial cell types that is critical for cellular and tissue function.
It is composed of numerous components conserved among all bilaterians [1]; however,
it is unknown how all of these components are generated and subsequently constructed
to form a fully mature BM in the living animal. Although BM formation is thought
to simply involve a process of self-assembly [2], this concept suffers from a
number of logistical issues when considering its construction in vivo. First,
incorporation of BM components appears to be hierarchical [3-5], yet it is unclear
whether their production during embryogenesis must also be regulated in a temporal
fashion. Second, many BM proteins are produced not only by the cells residing
on the BM but also by surrounding cell types [6-9], and it is unclear how large,
possibly insoluble protein complexes [10] are delivered into the matrix. Here
we exploit our ability to live image and genetically dissect de novo BM formation
during Drosophila development. This reveals that there is a temporal hierarchy
of BM protein production that is essential for proper component incorporation.
Furthermore, we show that BM components require secretion by migrating macrophages
(hemocytes) during their developmental dispersal, which is critical for embryogenesis.
Indeed, hemocyte migration is essential to deliver a subset of ECM components
evenly throughout the embryo. This reveals that de novo BM construction requires
a combination of both production and distribution logistics allowing for the timely
delivery of core components.
article_processing_charge: No
author:
- first_name: Yutaka
full_name: Matsubayashi, Yutaka
last_name: Matsubayashi
- first_name: Adam
full_name: Louani, Adam
last_name: Louani
- first_name: Anca
full_name: Dragu, Anca
last_name: Dragu
- first_name: Besaiz
full_name: Sanchez Sanchez, Besaiz
last_name: Sanchez Sanchez
- first_name: Eduardo
full_name: Serna Morales, Eduardo
last_name: Serna Morales
- first_name: Lawrence
full_name: Yolland, Lawrence
last_name: Yolland
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Gema
full_name: Vizcay, Gema
last_name: Vizcay
- first_name: Roland
full_name: Fleck, Roland
last_name: Fleck
- first_name: John
full_name: Heddleston, John
last_name: Heddleston
- first_name: Teng
full_name: Chew, Teng
last_name: Chew
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Brian
full_name: Stramer, Brian
last_name: Stramer
citation:
ama: Matsubayashi Y, Louani A, Dragu A, et al. A moving source of matrix components
is essential for De Novo basement membrane formation. Current Biology.
2017;27(22):3526-3534e.4. doi:10.1016/j.cub.2017.10.001
apa: Matsubayashi, Y., Louani, A., Dragu, A., Sanchez Sanchez, B., Serna Morales,
E., Yolland, L., … Stramer, B. (2017). A moving source of matrix components is
essential for De Novo basement membrane formation. Current Biology. Cell
Press. https://doi.org/10.1016/j.cub.2017.10.001
chicago: Matsubayashi, Yutaka, Adam Louani, Anca Dragu, Besaiz Sanchez Sanchez,
Eduardo Serna Morales, Lawrence Yolland, Attila György, et al. “A Moving Source
of Matrix Components Is Essential for De Novo Basement Membrane Formation.” Current
Biology. Cell Press, 2017. https://doi.org/10.1016/j.cub.2017.10.001.
ieee: Y. Matsubayashi et al., “A moving source of matrix components is essential
for De Novo basement membrane formation,” Current Biology, vol. 27, no.
22. Cell Press, p. 3526–3534e.4, 2017.
ista: Matsubayashi Y, Louani A, Dragu A, Sanchez Sanchez B, Serna Morales E, Yolland
L, György A, Vizcay G, Fleck R, Heddleston J, Chew T, Siekhaus DE, Stramer B.
2017. A moving source of matrix components is essential for De Novo basement membrane
formation. Current Biology. 27(22), 3526–3534e.4.
mla: Matsubayashi, Yutaka, et al. “A Moving Source of Matrix Components Is Essential
for De Novo Basement Membrane Formation.” Current Biology, vol. 27, no.
22, Cell Press, 2017, p. 3526–3534e.4, doi:10.1016/j.cub.2017.10.001.
short: Y. Matsubayashi, A. Louani, A. Dragu, B. Sanchez Sanchez, E. Serna Morales,
L. Yolland, A. György, G. Vizcay, R. Fleck, J. Heddleston, T. Chew, D.E. Siekhaus,
B. Stramer, Current Biology 27 (2017) 3526–3534e.4.
date_created: 2018-12-11T11:48:18Z
date_published: 2017-11-09T00:00:00Z
date_updated: 2023-09-27T12:25:31Z
day: '09'
ddc:
- '570'
- '576'
department:
- _id: DaSi
doi: 10.1016/j.cub.2017.10.001
external_id:
isi:
- '000415815800031'
file:
- access_level: open_access
checksum: 264cf6c6c3551486ba5ea786850e000a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:09:45Z
date_updated: 2020-07-14T12:47:59Z
file_id: '4770'
file_name: IST-2017-875-v1+1_1-s2.0-S0960982217312691-main.pdf
file_size: 4770657
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 27'
isi: 1
issue: '22'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 3526 - 3534e.4
publication: Current Biology
publication_identifier:
issn:
- '09609822'
publication_status: published
publisher: Cell Press
publist_id: '6905'
pubrep_id: '875'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A moving source of matrix components is essential for De Novo basement membrane
formation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 27
year: '2017'
...
---
_id: '7725'
abstract:
- lang: eng
text: Phenotypic plasticity is the ability of an individual genotype to alter aspects
of its phenotype depending on the current environment. It is central to the persistence,
resistance and resilience of populations facing variation in physical or biological
factors. Genetic variation in plasticity is pervasive, which suggests its local
adaptation is plausible. Existing studies on the adaptation of plasticity typically
focus on single traits and a few populations, while theory about interactions
among genes (for example, pleiotropy) suggests that a multi-trait, landscape scale
(for example, multiple populations) perspective is required. We present data from
a landscape scale, replicated, multi-trait experiment using a classic predator–prey
system centred on the water flea Daphnia pulex. We find predator regime-driven
differences in genetic variation of multivariate plasticity. These differences
are associated with strong divergent selection linked to a predation regime. Our
findings are evidence for local adaptation of plasticity, suggesting that responses
of populations to environmental variation depend on the conditions in which they
evolved in the past.
article_processing_charge: No
article_type: original
author:
- first_name: Julia
full_name: Reger, Julia
last_name: Reger
- first_name: Martin I.
full_name: Lind, Martin I.
last_name: Lind
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Andrew P.
full_name: Beckerman, Andrew P.
last_name: Beckerman
citation:
ama: Reger J, Lind MI, Robinson MR, Beckerman AP. Predation drives local adaptation
of phenotypic plasticity. Nature Ecology & Evolution. 2017;2:100-107.
doi:10.1038/s41559-017-0373-6
apa: Reger, J., Lind, M. I., Robinson, M. R., & Beckerman, A. P. (2017). Predation
drives local adaptation of phenotypic plasticity. Nature Ecology & Evolution.
Springer Nature. https://doi.org/10.1038/s41559-017-0373-6
chicago: Reger, Julia, Martin I. Lind, Matthew Richard Robinson, and Andrew P. Beckerman.
“Predation Drives Local Adaptation of Phenotypic Plasticity.” Nature Ecology
& Evolution. Springer Nature, 2017. https://doi.org/10.1038/s41559-017-0373-6.
ieee: J. Reger, M. I. Lind, M. R. Robinson, and A. P. Beckerman, “Predation drives
local adaptation of phenotypic plasticity,” Nature Ecology & Evolution,
vol. 2. Springer Nature, pp. 100–107, 2017.
ista: Reger J, Lind MI, Robinson MR, Beckerman AP. 2017. Predation drives local
adaptation of phenotypic plasticity. Nature Ecology & Evolution. 2, 100–107.
mla: Reger, Julia, et al. “Predation Drives Local Adaptation of Phenotypic Plasticity.”
Nature Ecology & Evolution, vol. 2, Springer Nature, 2017, pp. 100–07,
doi:10.1038/s41559-017-0373-6.
short: J. Reger, M.I. Lind, M.R. Robinson, A.P. Beckerman, Nature Ecology &
Evolution 2 (2017) 100–107.
date_created: 2020-04-30T10:46:02Z
date_published: 2017-11-27T00:00:00Z
date_updated: 2021-01-12T08:15:07Z
day: '27'
doi: 10.1038/s41559-017-0373-6
extern: '1'
intvolume: ' 2'
language:
- iso: eng
month: '11'
oa_version: None
page: 100-107
publication: Nature Ecology & Evolution
publication_identifier:
issn:
- 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Predation drives local adaptation of phenotypic plasticity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2017'
...
---
_id: '7727'
abstract:
- lang: eng
text: Genes of the major histocompatibility complex (MHC) have been shown to influence
social signalling and mate preferences in many species, including humans. First
observations suggest that MHC signalling may also affect female fertility. To
test this hypothesis, we exposed 191 female horses (Equus caballus) to either
an MHC-similar or an MHC-dissimilar stimulus male around the time of ovulation
and conception. A within-subject experimental design controlled for non-MHC-linked
male characteristics, and instrumental insemination with semen of other males
(n = 106) controlled for potential confounding effects of semen or embryo characteristics.
We found that females were more likely to become pregnant if exposed to an MHC-dissimilar
than to an MHC-similar male, while overall genetic distance to the stimulus males
(based on microsatellite markers on 20 chromosomes) had no effect. Our results
demonstrate that early pregnancy failures can be due to maternal life-history
decisions (cryptic female choice) influenced by MHC-linked social signalling.
article_number: '20171824'
article_processing_charge: No
article_type: original
author:
- first_name: D.
full_name: Burger, D.
last_name: Burger
- first_name: S.
full_name: Thomas, S.
last_name: Thomas
- first_name: H.
full_name: Aepli, H.
last_name: Aepli
- first_name: M.
full_name: Dreyer, M.
last_name: Dreyer
- first_name: G.
full_name: Fabre, G.
last_name: Fabre
- first_name: E.
full_name: Marti, E.
last_name: Marti
- first_name: H.
full_name: Sieme, H.
last_name: Sieme
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: C.
full_name: Wedekind, C.
last_name: Wedekind
citation:
ama: 'Burger D, Thomas S, Aepli H, et al. Major histocompatibility complex-linked
social signalling affects female fertility. Proceedings of the Royal Society
B: Biological Sciences. 2017;284(1868). doi:10.1098/rspb.2017.1824'
apa: 'Burger, D., Thomas, S., Aepli, H., Dreyer, M., Fabre, G., Marti, E., … Wedekind,
C. (2017). Major histocompatibility complex-linked social signalling affects female
fertility. Proceedings of the Royal Society B: Biological Sciences. The
Royal Society. https://doi.org/10.1098/rspb.2017.1824'
chicago: 'Burger, D., S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme,
Matthew Richard Robinson, and C. Wedekind. “Major Histocompatibility Complex-Linked
Social Signalling Affects Female Fertility.” Proceedings of the Royal Society
B: Biological Sciences. The Royal Society, 2017. https://doi.org/10.1098/rspb.2017.1824.'
ieee: 'D. Burger et al., “Major histocompatibility complex-linked social
signalling affects female fertility,” Proceedings of the Royal Society B: Biological
Sciences, vol. 284, no. 1868. The Royal Society, 2017.'
ista: 'Burger D, Thomas S, Aepli H, Dreyer M, Fabre G, Marti E, Sieme H, Robinson
MR, Wedekind C. 2017. Major histocompatibility complex-linked social signalling
affects female fertility. Proceedings of the Royal Society B: Biological Sciences.
284(1868), 20171824.'
mla: 'Burger, D., et al. “Major Histocompatibility Complex-Linked Social Signalling
Affects Female Fertility.” Proceedings of the Royal Society B: Biological Sciences,
vol. 284, no. 1868, 20171824, The Royal Society, 2017, doi:10.1098/rspb.2017.1824.'
short: 'D. Burger, S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme,
M.R. Robinson, C. Wedekind, Proceedings of the Royal Society B: Biological Sciences
284 (2017).'
date_created: 2020-04-30T10:46:43Z
date_published: 2017-12-06T00:00:00Z
date_updated: 2021-01-12T08:15:08Z
day: '06'
doi: 10.1098/rspb.2017.1824
extern: '1'
external_id:
pmid:
- '29212724'
intvolume: ' 284'
issue: '1868'
language:
- iso: eng
month: '12'
oa_version: None
pmid: 1
publication: 'Proceedings of the Royal Society B: Biological Sciences'
publication_identifier:
issn:
- 0962-8452
- 1471-2954
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
status: public
title: Major histocompatibility complex-linked social signalling affects female fertility
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 284
year: '2017'
...
---
_id: '7728'
abstract:
- lang: eng
text: 'Meta-analyses of genome-wide association studies, which dominate genetic
discovery, are based on data from diverse historical time periods and populations.
Genetic scores derived from genome-wide association studies explain only a fraction
of the heritability estimates obtained from whole-genome studies on single populations,
known as the ‘hidden heritability’ puzzle. Using seven sampling populations (n = 35,062),
we test whether hidden heritability is attributed to heterogeneity across sampling
populations and time, showing that estimates are substantially smaller across
populations compared with within populations. We show that the hidden heritability
varies substantially: from zero for height to 20% for body mass index, 37% for
education, 40% for age at first birth and up to 75% for number of children. Simulations
demonstrate that our results are more likely to reflect heterogeneity in phenotypic
measurement or gene–environment interactions than genetic heterogeneity. These
findings have substantial implications for genetic discovery, suggesting that
large homogenous datasets are required for behavioural phenotypes and that gene–environment
interaction may be a central challenge for genetic discovery.'
article_processing_charge: No
article_type: original
author:
- first_name: Felix C.
full_name: Tropf, Felix C.
last_name: Tropf
- first_name: S. Hong
full_name: Lee, S. Hong
last_name: Lee
- first_name: Renske M.
full_name: Verweij, Renske M.
last_name: Verweij
- first_name: Gert
full_name: Stulp, Gert
last_name: Stulp
- first_name: Peter J.
full_name: van der Most, Peter J.
last_name: van der Most
- first_name: Ronald
full_name: de Vlaming, Ronald
last_name: de Vlaming
- first_name: Andrew
full_name: Bakshi, Andrew
last_name: Bakshi
- first_name: Daniel A.
full_name: Briley, Daniel A.
last_name: Briley
- first_name: Charles
full_name: Rahal, Charles
last_name: Rahal
- first_name: Robert
full_name: Hellpap, Robert
last_name: Hellpap
- first_name: Anastasia N.
full_name: Iliadou, Anastasia N.
last_name: Iliadou
- first_name: Tõnu
full_name: Esko, Tõnu
last_name: Esko
- first_name: Andres
full_name: Metspalu, Andres
last_name: Metspalu
- first_name: Sarah E.
full_name: Medland, Sarah E.
last_name: Medland
- first_name: Nicholas G.
full_name: Martin, Nicholas G.
last_name: Martin
- first_name: Nicola
full_name: Barban, Nicola
last_name: Barban
- first_name: Harold
full_name: Snieder, Harold
last_name: Snieder
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Melinda C.
full_name: Mills, Melinda C.
last_name: Mills
citation:
ama: Tropf FC, Lee SH, Verweij RM, et al. Hidden heritability due to heterogeneity
across seven populations. Nature Human Behaviour. 2017;1(10):757-765. doi:10.1038/s41562-017-0195-1
apa: Tropf, F. C., Lee, S. H., Verweij, R. M., Stulp, G., van der Most, P. J., de
Vlaming, R., … Mills, M. C. (2017). Hidden heritability due to heterogeneity across
seven populations. Nature Human Behaviour. Springer Nature. https://doi.org/10.1038/s41562-017-0195-1
chicago: Tropf, Felix C., S. Hong Lee, Renske M. Verweij, Gert Stulp, Peter J. van
der Most, Ronald de Vlaming, Andrew Bakshi, et al. “Hidden Heritability Due to
Heterogeneity across Seven Populations.” Nature Human Behaviour. Springer
Nature, 2017. https://doi.org/10.1038/s41562-017-0195-1.
ieee: F. C. Tropf et al., “Hidden heritability due to heterogeneity across
seven populations,” Nature Human Behaviour, vol. 1, no. 10. Springer Nature,
pp. 757–765, 2017.
ista: Tropf FC, Lee SH, Verweij RM, Stulp G, van der Most PJ, de Vlaming R, Bakshi
A, Briley DA, Rahal C, Hellpap R, Iliadou AN, Esko T, Metspalu A, Medland SE,
Martin NG, Barban N, Snieder H, Robinson MR, Mills MC. 2017. Hidden heritability
due to heterogeneity across seven populations. Nature Human Behaviour. 1(10),
757–765.
mla: Tropf, Felix C., et al. “Hidden Heritability Due to Heterogeneity across Seven
Populations.” Nature Human Behaviour, vol. 1, no. 10, Springer Nature,
2017, pp. 757–65, doi:10.1038/s41562-017-0195-1.
short: F.C. Tropf, S.H. Lee, R.M. Verweij, G. Stulp, P.J. van der Most, R. de Vlaming,
A. Bakshi, D.A. Briley, C. Rahal, R. Hellpap, A.N. Iliadou, T. Esko, A. Metspalu,
S.E. Medland, N.G. Martin, N. Barban, H. Snieder, M.R. Robinson, M.C. Mills, Nature
Human Behaviour 1 (2017) 757–765.
date_created: 2020-04-30T10:47:02Z
date_published: 2017-09-11T00:00:00Z
date_updated: 2021-01-12T08:15:08Z
day: '11'
doi: 10.1038/s41562-017-0195-1
extern: '1'
intvolume: ' 1'
issue: '10'
language:
- iso: eng
month: '09'
oa_version: None
page: 757-765
publication: Nature Human Behaviour
publication_identifier:
issn:
- 2397-3374
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Hidden heritability due to heterogeneity across seven populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2017'
...
---
_id: '7729'
abstract:
- lang: eng
text: Quantifying the effects of inbreeding is critical to characterizing the genetic
architecture of complex traits. This study highlights through theory and simulations
the strengths and shortcomings of three SNP-based inbreeding measures commonly
used to estimate inbreeding depression (ID). We demonstrate that heterogeneity
in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates,
and we develop an approach to correct this bias using LD and minor allele frequency
stratified inference (LDMS). We quantified ID in 25 traits measured in ∼140,000
participants of the UK Biobank, using LDMS, and confirmed previously published
ID for 4 traits. We find unique evidence of ID for handgrip strength, waist/hip
ratio, and visual and auditory acuity (ID between −2.3 and −5.2 phenotypic SDs
for complete inbreeding; P<0.001). Our results illustrate that a careful choice
of the measure of inbreeding combined with LDMS stratification improves both detection
and quantification of ID using SNP data.
article_processing_charge: No
article_type: original
author:
- first_name: Loic
full_name: Yengo, Loic
last_name: Yengo
- first_name: Zhihong
full_name: Zhu, Zhihong
last_name: Zhu
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
- first_name: Bruce S.
full_name: Weir, Bruce S.
last_name: Weir
- first_name: Jian
full_name: Yang, Jian
last_name: Yang
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Peter M.
full_name: Visscher, Peter M.
last_name: Visscher
citation:
ama: Yengo L, Zhu Z, Wray NR, et al. Detection and quantification of inbreeding
depression for complex traits from SNP data. Proceedings of the National Academy
of Sciences. 2017;114(32):8602-8607. doi:10.1073/pnas.1621096114
apa: Yengo, L., Zhu, Z., Wray, N. R., Weir, B. S., Yang, J., Robinson, M. R., &
Visscher, P. M. (2017). Detection and quantification of inbreeding depression
for complex traits from SNP data. Proceedings of the National Academy of Sciences.
Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1621096114
chicago: Yengo, Loic, Zhihong Zhu, Naomi R. Wray, Bruce S. Weir, Jian Yang, Matthew
Richard Robinson, and Peter M. Visscher. “Detection and Quantification of Inbreeding
Depression for Complex Traits from SNP Data.” Proceedings of the National Academy
of Sciences. Proceedings of the National Academy of Sciences, 2017. https://doi.org/10.1073/pnas.1621096114.
ieee: L. Yengo et al., “Detection and quantification of inbreeding depression
for complex traits from SNP data,” Proceedings of the National Academy of Sciences,
vol. 114, no. 32. Proceedings of the National Academy of Sciences, pp. 8602–8607,
2017.
ista: Yengo L, Zhu Z, Wray NR, Weir BS, Yang J, Robinson MR, Visscher PM. 2017.
Detection and quantification of inbreeding depression for complex traits from
SNP data. Proceedings of the National Academy of Sciences. 114(32), 8602–8607.
mla: Yengo, Loic, et al. “Detection and Quantification of Inbreeding Depression
for Complex Traits from SNP Data.” Proceedings of the National Academy of Sciences,
vol. 114, no. 32, Proceedings of the National Academy of Sciences, 2017, pp. 8602–07,
doi:10.1073/pnas.1621096114.
short: L. Yengo, Z. Zhu, N.R. Wray, B.S. Weir, J. Yang, M.R. Robinson, P.M. Visscher,
Proceedings of the National Academy of Sciences 114 (2017) 8602–8607.
date_created: 2020-04-30T10:47:19Z
date_published: 2017-08-08T00:00:00Z
date_updated: 2021-01-12T08:15:09Z
day: '08'
doi: 10.1073/pnas.1621096114
extern: '1'
intvolume: ' 114'
issue: '32'
language:
- iso: eng
month: '08'
oa_version: None
page: 8602-8607
publication: Proceedings of the National Academy of Sciences
publication_identifier:
issn:
- 0027-8424
- 1091-6490
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
related_material:
link:
- relation: other
url: https://doi.org/10.1073/pnas.1718598115
status: public
title: Detection and quantification of inbreeding depression for complex traits from
SNP data
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '7731'
abstract:
- lang: eng
text: 'Genetic association studies in admixed populations are underrepresented in
the genomics literature, with a key concern for researchers being the adequate
control of spurious associations due to population structure. Linear mixed models
(LMMs) are well suited for genome-wide association studies (GWAS) because they
account for both population stratification and cryptic relatedness and achieve
increased statistical power by jointly modeling all genotyped markers. Additionally,
Bayesian LMMs allow for more flexible assumptions about the underlying distribution
of genetic effects, and can concurrently estimate the proportion of phenotypic
variance explained by genetic markers. Using three recently published Bayesian
LMMs, Bayes R, BSLMM, and BOLT-LMM, we investigate an existing data set on eye
(n = 625) and skin (n = 684) color from Cape Verde, an island nation off West
Africa that is home to individuals with a broad range of phenotypic values for
eye and skin color due to the mix of West African and European ancestry. We use
simulations to demonstrate the utility of Bayesian LMMs for mapping loci and studying
the genetic architecture of quantitative traits in admixed populations. The Bayesian
LMMs provide evidence for two new pigmentation loci: one for eye color (AHRR)
and one for skin color (DDB1).'
article_processing_charge: No
article_type: original
author:
- first_name: Luke R.
full_name: Lloyd-Jones, Luke R.
last_name: Lloyd-Jones
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Gerhard
full_name: Moser, Gerhard
last_name: Moser
- first_name: Jian
full_name: Zeng, Jian
last_name: Zeng
- first_name: Sandra
full_name: Beleza, Sandra
last_name: Beleza
- first_name: Gregory S.
full_name: Barsh, Gregory S.
last_name: Barsh
- first_name: Hua
full_name: Tang, Hua
last_name: Tang
- first_name: Peter M.
full_name: Visscher, Peter M.
last_name: Visscher
citation:
ama: Lloyd-Jones LR, Robinson MR, Moser G, et al. Inference on the genetic basis
of eye and skin color in an admixed population via Bayesian linear mixed models.
Genetics. 2017;206(2):1113-1126. doi:10.1534/genetics.116.193383
apa: Lloyd-Jones, L. R., Robinson, M. R., Moser, G., Zeng, J., Beleza, S., Barsh,
G. S., … Visscher, P. M. (2017). Inference on the genetic basis of eye and skin
color in an admixed population via Bayesian linear mixed models. Genetics.
Genetics Society of America. https://doi.org/10.1534/genetics.116.193383
chicago: Lloyd-Jones, Luke R., Matthew Richard Robinson, Gerhard Moser, Jian Zeng,
Sandra Beleza, Gregory S. Barsh, Hua Tang, and Peter M. Visscher. “Inference on
the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian
Linear Mixed Models.” Genetics. Genetics Society of America, 2017. https://doi.org/10.1534/genetics.116.193383.
ieee: L. R. Lloyd-Jones et al., “Inference on the genetic basis of eye and
skin color in an admixed population via Bayesian linear mixed models,” Genetics,
vol. 206, no. 2. Genetics Society of America, pp. 1113–1126, 2017.
ista: Lloyd-Jones LR, Robinson MR, Moser G, Zeng J, Beleza S, Barsh GS, Tang H,
Visscher PM. 2017. Inference on the genetic basis of eye and skin color in an
admixed population via Bayesian linear mixed models. Genetics. 206(2), 1113–1126.
mla: Lloyd-Jones, Luke R., et al. “Inference on the Genetic Basis of Eye and Skin
Color in an Admixed Population via Bayesian Linear Mixed Models.” Genetics,
vol. 206, no. 2, Genetics Society of America, 2017, pp. 1113–26, doi:10.1534/genetics.116.193383.
short: L.R. Lloyd-Jones, M.R. Robinson, G. Moser, J. Zeng, S. Beleza, G.S. Barsh,
H. Tang, P.M. Visscher, Genetics 206 (2017) 1113–1126.
date_created: 2020-04-30T10:47:50Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:15:10Z
day: '01'
doi: 10.1534/genetics.116.193383
extern: '1'
intvolume: ' 206'
issue: '2'
language:
- iso: eng
month: '06'
oa_version: None
page: 1113-1126
publication: Genetics
publication_identifier:
issn:
- 0016-6731
- 1943-2631
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: Inference on the genetic basis of eye and skin color in an admixed population
via Bayesian linear mixed models
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 206
year: '2017'
...
---
_id: '7733'
abstract:
- lang: eng
text: "Sections\r\nPDFPDF\r\nTools\r\nShare\r\nAbstract\r\nBackground: Gene discovery
has provided remarkable biological insights into amyotrophic lateral sclerosis
(ALS). One challenge for clinical application of genetic testing is critical evaluation
of the significance of reported variants.\r\nMethods: We use whole exome sequencing
(WES) to develop a clinically relevant approach to identify a subset of ALS patients
harboring likely pathogenic mutations. In parallel, we assess if DNA methylation
can be used to screen for pathogenicity of novel variants since a methylation
signature has been shown to associate with the pathogenic C9orf72 expansion, but
has not been explored for other ALS mutations. Australian patients identified
with ALS‐relevant variants were cross‐checked with population databases and case
reports to critically assess whether they were “likely causal,” “uncertain significance,”
or “unlikely causal.”\r\nResults: Published ALS variants were identified in >10%
of patients; however, in only 3% of patients (4/120) could these be confidently
considered pathogenic (in SOD1 and TARDBP). We found no evidence for a differential
DNA methylation signature in these mutation carriers.\r\nConclusions: The use
of WES in a typical ALS clinic demonstrates a critical approach to variant assessment
with the capability to combine cohorts to enhance the largely unknown genetic
basis of ALS."
article_processing_charge: No
article_type: original
author:
- first_name: Fleur C.
full_name: Garton, Fleur C.
last_name: Garton
- first_name: Beben
full_name: Benyamin, Beben
last_name: Benyamin
- first_name: Qiongyi
full_name: Zhao, Qiongyi
last_name: Zhao
- first_name: Zhijun
full_name: Liu, Zhijun
last_name: Liu
- first_name: Jacob
full_name: Gratten, Jacob
last_name: Gratten
- first_name: Anjali K.
full_name: Henders, Anjali K.
last_name: Henders
- first_name: Zong-Hong
full_name: Zhang, Zong-Hong
last_name: Zhang
- first_name: Janette
full_name: Edson, Janette
last_name: Edson
- first_name: Sarah
full_name: Furlong, Sarah
last_name: Furlong
- first_name: Sarah
full_name: Morgan, Sarah
last_name: Morgan
- first_name: Susan
full_name: Heggie, Susan
last_name: Heggie
- first_name: Kathryn
full_name: Thorpe, Kathryn
last_name: Thorpe
- first_name: Casey
full_name: Pfluger, Casey
last_name: Pfluger
- first_name: Karen A.
full_name: Mather, Karen A.
last_name: Mather
- first_name: Perminder S.
full_name: Sachdev, Perminder S.
last_name: Sachdev
- first_name: Allan F.
full_name: McRae, Allan F.
last_name: McRae
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Sonia
full_name: Shah, Sonia
last_name: Shah
- first_name: Peter M.
full_name: Visscher, Peter M.
last_name: Visscher
- first_name: Marie
full_name: Mangelsdorf, Marie
last_name: Mangelsdorf
- first_name: Robert D.
full_name: Henderson, Robert D.
last_name: Henderson
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
- first_name: Pamela A.
full_name: McCombe, Pamela A.
last_name: McCombe
citation:
ama: Garton FC, Benyamin B, Zhao Q, et al. Whole exome sequencing and DNA methylation
analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics
& Genomic Medicine. 2017;5(4):418-428. doi:10.1002/mgg3.302
apa: Garton, F. C., Benyamin, B., Zhao, Q., Liu, Z., Gratten, J., Henders, A. K.,
… McCombe, P. A. (2017). Whole exome sequencing and DNA methylation analysis in
a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics & Genomic
Medicine. Wiley. https://doi.org/10.1002/mgg3.302
chicago: Garton, Fleur C., Beben Benyamin, Qiongyi Zhao, Zhijun Liu, Jacob Gratten,
Anjali K. Henders, Zong-Hong Zhang, et al. “Whole Exome Sequencing and DNA Methylation
Analysis in a Clinical Amyotrophic Lateral Sclerosis Cohort.” Molecular Genetics
& Genomic Medicine. Wiley, 2017. https://doi.org/10.1002/mgg3.302.
ieee: F. C. Garton et al., “Whole exome sequencing and DNA methylation analysis
in a clinical amyotrophic lateral sclerosis cohort,” Molecular Genetics &
Genomic Medicine, vol. 5, no. 4. Wiley, pp. 418–428, 2017.
ista: Garton FC, Benyamin B, Zhao Q, Liu Z, Gratten J, Henders AK, Zhang Z-H, Edson
J, Furlong S, Morgan S, Heggie S, Thorpe K, Pfluger C, Mather KA, Sachdev PS,
McRae AF, Robinson MR, Shah S, Visscher PM, Mangelsdorf M, Henderson RD, Wray
NR, McCombe PA. 2017. Whole exome sequencing and DNA methylation analysis in a
clinical amyotrophic lateral sclerosis cohort. Molecular Genetics & Genomic
Medicine. 5(4), 418–428.
mla: Garton, Fleur C., et al. “Whole Exome Sequencing and DNA Methylation Analysis
in a Clinical Amyotrophic Lateral Sclerosis Cohort.” Molecular Genetics &
Genomic Medicine, vol. 5, no. 4, Wiley, 2017, pp. 418–28, doi:10.1002/mgg3.302.
short: F.C. Garton, B. Benyamin, Q. Zhao, Z. Liu, J. Gratten, A.K. Henders, Z.-H.
Zhang, J. Edson, S. Furlong, S. Morgan, S. Heggie, K. Thorpe, C. Pfluger, K.A.
Mather, P.S. Sachdev, A.F. McRae, M.R. Robinson, S. Shah, P.M. Visscher, M. Mangelsdorf,
R.D. Henderson, N.R. Wray, P.A. McCombe, Molecular Genetics & Genomic Medicine
5 (2017) 418–428.
date_created: 2020-04-30T10:48:25Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2021-01-12T08:15:10Z
day: '01'
doi: 10.1002/mgg3.302
extern: '1'
intvolume: ' 5'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/mgg3.302
month: '07'
oa: 1
oa_version: Published Version
page: 418-428
publication: Molecular Genetics & Genomic Medicine
publication_identifier:
issn:
- 2324-9269
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic
lateral sclerosis cohort
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2017'
...
---
_id: '7755'
abstract:
- lang: eng
text: We give a bird's-eye view of the plastic deformation of crystals aimed at
the statistical physics community, as well as a broad introduction to the statistical
theories of forced rigid systems aimed at the plasticity community. Memory effects
in magnets, spin glasses, charge density waves, and dilute colloidal suspensions
are discussed in relation to the onset of plastic yielding in crystals. Dislocation
avalanches and complex dislocation tangles are discussed via a brief introduction
to the renormalization group and scaling. Analogies to emergent scale invariance
in fracture, jamming, coarsening, and a variety of depinning transitions are explored.
Dislocation dynamics in crystals challenge nonequilibrium statistical physics.
Statistical physics provides both cautionary tales of subtle memory effects in
nonequilibrium systems and systematic tools designed to address complex scale-invariant
behavior on multiple length scales and timescales.
article_processing_charge: No
article_type: original
author:
- first_name: James P.
full_name: Sethna, James P.
last_name: Sethna
- first_name: Matthew K.
full_name: Bierbaum, Matthew K.
last_name: Bierbaum
- first_name: Karin A.
full_name: Dahmen, Karin A.
last_name: Dahmen
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Julia R.
full_name: Greer, Julia R.
last_name: Greer
- first_name: Lorien X.
full_name: Hayden, Lorien X.
last_name: Hayden
- first_name: Jaron P.
full_name: Kent-Dobias, Jaron P.
last_name: Kent-Dobias
- first_name: Edward D.
full_name: Lee, Edward D.
last_name: Lee
- first_name: Danilo B.
full_name: Liarte, Danilo B.
last_name: Liarte
- first_name: Xiaoyue
full_name: Ni, Xiaoyue
last_name: Ni
- first_name: Katherine N.
full_name: Quinn, Katherine N.
last_name: Quinn
- first_name: Archishman
full_name: Raju, Archishman
last_name: Raju
- first_name: D. Zeb
full_name: Rocklin, D. Zeb
last_name: Rocklin
- first_name: Ashivni
full_name: Shekhawat, Ashivni
last_name: Shekhawat
- first_name: Stefano
full_name: Zapperi, Stefano
last_name: Zapperi
citation:
ama: 'Sethna JP, Bierbaum MK, Dahmen KA, et al. Deformation of crystals: Connections
with statistical physics. Annual Review of Materials Research. 2017;47:217-246.
doi:10.1146/annurev-matsci-070115-032036'
apa: 'Sethna, J. P., Bierbaum, M. K., Dahmen, K. A., Goodrich, C. P., Greer, J.
R., Hayden, L. X., … Zapperi, S. (2017). Deformation of crystals: Connections
with statistical physics. Annual Review of Materials Research. Annual Reviews.
https://doi.org/10.1146/annurev-matsci-070115-032036'
chicago: 'Sethna, James P., Matthew K. Bierbaum, Karin A. Dahmen, Carl Peter Goodrich,
Julia R. Greer, Lorien X. Hayden, Jaron P. Kent-Dobias, et al. “Deformation of
Crystals: Connections with Statistical Physics.” Annual Review of Materials
Research. Annual Reviews, 2017. https://doi.org/10.1146/annurev-matsci-070115-032036.'
ieee: 'J. P. Sethna et al., “Deformation of crystals: Connections with statistical
physics,” Annual Review of Materials Research, vol. 47. Annual Reviews,
pp. 217–246, 2017.'
ista: 'Sethna JP, Bierbaum MK, Dahmen KA, Goodrich CP, Greer JR, Hayden LX, Kent-Dobias
JP, Lee ED, Liarte DB, Ni X, Quinn KN, Raju A, Rocklin DZ, Shekhawat A, Zapperi
S. 2017. Deformation of crystals: Connections with statistical physics. Annual
Review of Materials Research. 47, 217–246.'
mla: 'Sethna, James P., et al. “Deformation of Crystals: Connections with Statistical
Physics.” Annual Review of Materials Research, vol. 47, Annual Reviews,
2017, pp. 217–46, doi:10.1146/annurev-matsci-070115-032036.'
short: J.P. Sethna, M.K. Bierbaum, K.A. Dahmen, C.P. Goodrich, J.R. Greer, L.X.
Hayden, J.P. Kent-Dobias, E.D. Lee, D.B. Liarte, X. Ni, K.N. Quinn, A. Raju, D.Z.
Rocklin, A. Shekhawat, S. Zapperi, Annual Review of Materials Research 47 (2017)
217–246.
date_created: 2020-04-30T11:38:24Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2021-01-12T08:15:18Z
day: '01'
doi: 10.1146/annurev-matsci-070115-032036
extern: '1'
intvolume: ' 47'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1146/annurev-matsci-070115-032036
month: '07'
oa: 1
oa_version: Published Version
page: 217-246
publication: Annual Review of Materials Research
publication_identifier:
issn:
- 1531-7331
- 1545-4118
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
status: public
title: 'Deformation of crystals: Connections with statistical physics'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 47
year: '2017'
...
---
_id: '7756'
abstract:
- lang: eng
text: We study the shear jamming of athermal frictionless soft spheres, and find
that in the thermodynamic limit, a shear-jammed state exists with different elastic
properties from the isotropically-jammed state. For example, shear-jammed states
can have a non-zero residual shear stress in the thermodynamic limit that arises
from long-range stress-stress correlations. As a result, the ratio of the shear
and bulk moduli, which in isotropically-jammed systems vanishes as the jamming
transition is approached from above, instead approaches a constant. Despite these
striking differences, we argue that in a deeper sense, the shear jamming and isotropic
jamming transitions actually have the same symmetry, and that the differences
can be fully understood by rotating the six-dimensional basis of the elastic modulus
tensor.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Baity-Jesi, Marco
last_name: Baity-Jesi
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Andrea J.
full_name: Liu, Andrea J.
last_name: Liu
- first_name: Sidney R.
full_name: Nagel, Sidney R.
last_name: Nagel
- first_name: James P.
full_name: Sethna, James P.
last_name: Sethna
citation:
ama: Baity-Jesi M, Goodrich CP, Liu AJ, Nagel SR, Sethna JP. Emergent SO(3) symmetry
of the frictionless shear jamming transition. Journal of Statistical Physics.
2017;167(3-4):735-748. doi:10.1007/s10955-016-1703-9
apa: Baity-Jesi, M., Goodrich, C. P., Liu, A. J., Nagel, S. R., & Sethna, J.
P. (2017). Emergent SO(3) symmetry of the frictionless shear jamming transition.
Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-016-1703-9
chicago: Baity-Jesi, Marco, Carl Peter Goodrich, Andrea J. Liu, Sidney R. Nagel,
and James P. Sethna. “Emergent SO(3) Symmetry of the Frictionless Shear Jamming
Transition.” Journal of Statistical Physics. Springer Nature, 2017. https://doi.org/10.1007/s10955-016-1703-9.
ieee: M. Baity-Jesi, C. P. Goodrich, A. J. Liu, S. R. Nagel, and J. P. Sethna, “Emergent
SO(3) symmetry of the frictionless shear jamming transition,” Journal of Statistical
Physics, vol. 167, no. 3–4. Springer Nature, pp. 735–748, 2017.
ista: Baity-Jesi M, Goodrich CP, Liu AJ, Nagel SR, Sethna JP. 2017. Emergent SO(3)
symmetry of the frictionless shear jamming transition. Journal of Statistical
Physics. 167(3–4), 735–748.
mla: Baity-Jesi, Marco, et al. “Emergent SO(3) Symmetry of the Frictionless Shear
Jamming Transition.” Journal of Statistical Physics, vol. 167, no. 3–4,
Springer Nature, 2017, pp. 735–48, doi:10.1007/s10955-016-1703-9.
short: M. Baity-Jesi, C.P. Goodrich, A.J. Liu, S.R. Nagel, J.P. Sethna, Journal
of Statistical Physics 167 (2017) 735–748.
date_created: 2020-04-30T11:38:38Z
date_published: 2017-01-03T00:00:00Z
date_updated: 2021-01-12T08:15:19Z
day: '03'
doi: 10.1007/s10955-016-1703-9
extern: '1'
intvolume: ' 167'
issue: 3-4
language:
- iso: eng
month: '01'
oa_version: None
page: 735-748
publication: Journal of Statistical Physics
publication_identifier:
issn:
- 0022-4715
- 1572-9613
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Emergent SO(3) symmetry of the frictionless shear jamming transition
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 167
year: '2017'
...
---
_id: '7757'
abstract:
- lang: eng
text: Recent advances in designing metamaterials have demonstrated that global mechanical
properties of disordered spring networks can be tuned by selectively modifying
only a small subset of bonds. Here, using a computationally efficient approach,
we extend this idea to tune more general properties of networks. With nearly complete
success, we are able to produce a strain between any two target nodes in a network
in response to an applied source strain on any other pair of nodes by removing
only ∼1% of the bonds. We are also able to control multiple pairs of target nodes,
each with a different individual response, from a single source, and to tune multiple
independent source/target responses simultaneously into a network. We have fabricated
physical networks in macroscopic 2D and 3D systems that exhibit these responses.
This work is inspired by the long-range coupled conformational changes that constitute
allosteric function in proteins. The fact that allostery is a common means for
regulation in biological molecules suggests that it is a relatively easy property
to develop through evolution. In analogy, our results show that long-range coupled
mechanical responses are similarly easy to achieve in disordered networks.
article_processing_charge: No
article_type: original
author:
- first_name: Jason W.
full_name: Rocks, Jason W.
last_name: Rocks
- first_name: Nidhi
full_name: Pashine, Nidhi
last_name: Pashine
- first_name: Irmgard
full_name: Bischofberger, Irmgard
last_name: Bischofberger
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
- first_name: Andrea J.
full_name: Liu, Andrea J.
last_name: Liu
- first_name: Sidney R.
full_name: Nagel, Sidney R.
last_name: Nagel
citation:
ama: Rocks JW, Pashine N, Bischofberger I, Goodrich CP, Liu AJ, Nagel SR. Designing
allostery-inspired response in mechanical networks. Proceedings of the National
Academy of Sciences. 2017;114(10):2520-2525. doi:10.1073/pnas.1612139114
apa: Rocks, J. W., Pashine, N., Bischofberger, I., Goodrich, C. P., Liu, A. J.,
& Nagel, S. R. (2017). Designing allostery-inspired response in mechanical
networks. Proceedings of the National Academy of Sciences. Proceedings
of the National Academy of Sciences. https://doi.org/10.1073/pnas.1612139114
chicago: Rocks, Jason W., Nidhi Pashine, Irmgard Bischofberger, Carl Peter Goodrich,
Andrea J. Liu, and Sidney R. Nagel. “Designing Allostery-Inspired Response in
Mechanical Networks.” Proceedings of the National Academy of Sciences.
Proceedings of the National Academy of Sciences, 2017. https://doi.org/10.1073/pnas.1612139114.
ieee: J. W. Rocks, N. Pashine, I. Bischofberger, C. P. Goodrich, A. J. Liu, and
S. R. Nagel, “Designing allostery-inspired response in mechanical networks,” Proceedings
of the National Academy of Sciences, vol. 114, no. 10. Proceedings of the
National Academy of Sciences, pp. 2520–2525, 2017.
ista: Rocks JW, Pashine N, Bischofberger I, Goodrich CP, Liu AJ, Nagel SR. 2017.
Designing allostery-inspired response in mechanical networks. Proceedings of the
National Academy of Sciences. 114(10), 2520–2525.
mla: Rocks, Jason W., et al. “Designing Allostery-Inspired Response in Mechanical
Networks.” Proceedings of the National Academy of Sciences, vol. 114, no.
10, Proceedings of the National Academy of Sciences, 2017, pp. 2520–25, doi:10.1073/pnas.1612139114.
short: J.W. Rocks, N. Pashine, I. Bischofberger, C.P. Goodrich, A.J. Liu, S.R. Nagel,
Proceedings of the National Academy of Sciences 114 (2017) 2520–2525.
date_created: 2020-04-30T11:38:53Z
date_published: 2017-03-07T00:00:00Z
date_updated: 2021-01-12T08:15:19Z
day: '07'
doi: 10.1073/pnas.1612139114
extern: '1'
intvolume: ' 114'
issue: '10'
language:
- iso: eng
month: '03'
oa_version: None
page: 2520-2525
publication: Proceedings of the National Academy of Sciences
publication_identifier:
issn:
- 0027-8424
- 1091-6490
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
status: public
title: Designing allostery-inspired response in mechanical networks
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...