---
_id: '6867'
abstract:
- lang: eng
  text: A novel magnetic scratch method achieves repeatability, reproducibility and
    geometric control greater than pipette scratch assays and closely approximating
    the precision of cell exclusion assays while inducing the cell injury inherently
    necessary for wound healing assays. The magnetic scratch is affordable, easily
    implemented and standardisable and thus may contribute toward better comparability
    of data generated in different studies and laboratories.
article_number: '12625'
article_processing_charge: No
author:
- first_name: M.
  full_name: Fenu, M.
  last_name: Fenu
- first_name: T.
  full_name: Bettermann, T.
  last_name: Bettermann
- first_name: C.
  full_name: Vogl, C.
  last_name: Vogl
- first_name: Nasser
  full_name: Darwish-Miranda, Nasser
  id: 39CD9926-F248-11E8-B48F-1D18A9856A87
  last_name: Darwish-Miranda
  orcid: 0000-0002-8821-8236
- first_name: J.
  full_name: Schramel, J.
  last_name: Schramel
- first_name: F.
  full_name: Jenner, F.
  last_name: Jenner
- first_name: I.
  full_name: Ribitsch, I.
  last_name: Ribitsch
citation:
  ama: Fenu M, Bettermann T, Vogl C, et al. A novel magnet-based scratch method for
    standardisation of wound-healing assays. <i>Scientific Reports</i>. 2019;9(1).
    doi:<a href="https://doi.org/10.1038/s41598-019-48930-7">10.1038/s41598-019-48930-7</a>
  apa: Fenu, M., Bettermann, T., Vogl, C., Darwish-Miranda, N., Schramel, J., Jenner,
    F., &#38; Ribitsch, I. (2019). A novel magnet-based scratch method for standardisation
    of wound-healing assays. <i>Scientific Reports</i>. Springer Nature. <a href="https://doi.org/10.1038/s41598-019-48930-7">https://doi.org/10.1038/s41598-019-48930-7</a>
  chicago: Fenu, M., T. Bettermann, C. Vogl, Nasser Darwish-Miranda, J. Schramel,
    F. Jenner, and I. Ribitsch. “A Novel Magnet-Based Scratch Method for Standardisation
    of Wound-Healing Assays.” <i>Scientific Reports</i>. Springer Nature, 2019. <a
    href="https://doi.org/10.1038/s41598-019-48930-7">https://doi.org/10.1038/s41598-019-48930-7</a>.
  ieee: M. Fenu <i>et al.</i>, “A novel magnet-based scratch method for standardisation
    of wound-healing assays,” <i>Scientific Reports</i>, vol. 9, no. 1. Springer Nature,
    2019.
  ista: Fenu M, Bettermann T, Vogl C, Darwish-Miranda N, Schramel J, Jenner F, Ribitsch
    I. 2019. A novel magnet-based scratch method for standardisation of wound-healing
    assays. Scientific Reports. 9(1), 12625.
  mla: Fenu, M., et al. “A Novel Magnet-Based Scratch Method for Standardisation of
    Wound-Healing Assays.” <i>Scientific Reports</i>, vol. 9, no. 1, 12625, Springer
    Nature, 2019, doi:<a href="https://doi.org/10.1038/s41598-019-48930-7">10.1038/s41598-019-48930-7</a>.
  short: M. Fenu, T. Bettermann, C. Vogl, N. Darwish-Miranda, J. Schramel, F. Jenner,
    I. Ribitsch, Scientific Reports 9 (2019).
date_created: 2019-09-15T22:00:42Z
date_published: 2019-09-02T00:00:00Z
date_updated: 2023-08-29T07:55:15Z
day: '02'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1038/s41598-019-48930-7
external_id:
  isi:
  - '000483697800007'
  pmid:
  - '31477739'
file:
- access_level: open_access
  checksum: 9cfd986d4108e288cc72276ef047ab0c
  content_type: application/pdf
  creator: dernst
  date_created: 2019-09-16T12:42:40Z
  date_updated: 2020-07-14T12:47:42Z
  file_id: '6879'
  file_name: 2019_ScientificReports_Fenu.pdf
  file_size: 3523795
  relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
  eissn:
  - '20452322'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A novel magnet-based scratch method for standardisation of wound-healing assays
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2019'
...
---
_id: '6868'
abstract:
- lang: eng
  text: "Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels control
    electrical rhythmicity and excitability in the heart and brain, but the function
    of HCN channels at the subcellular level in axons remains poorly understood. Here,
    we show that the action potential conduction velocity in both myelinated and unmyelinated
    central axons can be bidirectionally modulated by a HCN channel blocker, cyclic
    adenosine monophosphate (cAMP), and neuromodulators. Recordings from mouse cerebellar
    mossy fiber boutons show that HCN channels ensure reliable high-frequency firing
    and are strongly modulated by cAMP (EC50 40 mM; estimated endogenous cAMP concentration
    13 mM). In addition, immunogold-electron microscopy revealed HCN2 as the dominating
    subunit in cerebellar mossy fibers. Computational modeling indicated that HCN2
    channels control conduction velocity primarily by altering the resting membrane
    potential\r\nand are associated with significant metabolic costs. These results
    suggest that the cAMP-HCN pathway provides neuromodulators with an opportunity
    to finely tune energy consumption and temporal delays across axons in the brain."
article_number: e42766
article_processing_charge: No
article_type: original
author:
- first_name: Niklas
  full_name: Byczkowicz, Niklas
  last_name: Byczkowicz
- first_name: Abdelmoneim
  full_name: Eshra, Abdelmoneim
  last_name: Eshra
- first_name: Jacqueline-Claire
  full_name: Montanaro-Punzengruber, Jacqueline-Claire
  id: 3786AB44-F248-11E8-B48F-1D18A9856A87
  last_name: Montanaro-Punzengruber
- first_name: Andrea
  full_name: Trevisiol, Andrea
  last_name: Trevisiol
- first_name: Johannes
  full_name: Hirrlinger, Johannes
  last_name: Hirrlinger
- first_name: Maarten Hp
  full_name: Kole, Maarten Hp
  last_name: Kole
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Stefan
  full_name: Hallermann, Stefan
  last_name: Hallermann
citation:
  ama: Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, et al. HCN channel-mediated
    neuromodulation can control action potential velocity and fidelity in central
    axons. <i>eLife</i>. 2019;8. doi:<a href="https://doi.org/10.7554/eLife.42766">10.7554/eLife.42766</a>
  apa: Byczkowicz, N., Eshra, A., Montanaro-Punzengruber, J.-C., Trevisiol, A., Hirrlinger,
    J., Kole, M. H., … Hallermann, S. (2019). HCN channel-mediated neuromodulation
    can control action potential velocity and fidelity in central axons. <i>ELife</i>.
    eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.42766">https://doi.org/10.7554/eLife.42766</a>
  chicago: Byczkowicz, Niklas, Abdelmoneim Eshra, Jacqueline-Claire Montanaro-Punzengruber,
    Andrea Trevisiol, Johannes Hirrlinger, Maarten Hp Kole, Ryuichi Shigemoto, and
    Stefan Hallermann. “HCN Channel-Mediated Neuromodulation Can Control Action Potential
    Velocity and Fidelity in Central Axons.” <i>ELife</i>. eLife Sciences Publications,
    2019. <a href="https://doi.org/10.7554/eLife.42766">https://doi.org/10.7554/eLife.42766</a>.
  ieee: N. Byczkowicz <i>et al.</i>, “HCN channel-mediated neuromodulation can control
    action potential velocity and fidelity in central axons,” <i>eLife</i>, vol. 8.
    eLife Sciences Publications, 2019.
  ista: Byczkowicz N, Eshra A, Montanaro-Punzengruber J-C, Trevisiol A, Hirrlinger
    J, Kole MH, Shigemoto R, Hallermann S. 2019. HCN channel-mediated neuromodulation
    can control action potential velocity and fidelity in central axons. eLife. 8,
    e42766.
  mla: Byczkowicz, Niklas, et al. “HCN Channel-Mediated Neuromodulation Can Control
    Action Potential Velocity and Fidelity in Central Axons.” <i>ELife</i>, vol. 8,
    e42766, eLife Sciences Publications, 2019, doi:<a href="https://doi.org/10.7554/eLife.42766">10.7554/eLife.42766</a>.
  short: N. Byczkowicz, A. Eshra, J.-C. Montanaro-Punzengruber, A. Trevisiol, J. Hirrlinger,
    M.H. Kole, R. Shigemoto, S. Hallermann, ELife 8 (2019).
date_created: 2019-09-15T22:00:43Z
date_published: 2019-09-09T00:00:00Z
date_updated: 2023-08-30T06:17:06Z
day: '09'
ddc:
- '570'
department:
- _id: RySh
doi: 10.7554/eLife.42766
external_id:
  isi:
  - '000485663900001'
file:
- access_level: open_access
  checksum: c350b7861ef0fb537cae8a3232aec016
  content_type: application/pdf
  creator: dernst
  date_created: 2019-09-16T13:14:33Z
  date_updated: 2020-07-14T12:47:42Z
  file_id: '6880'
  file_name: 2019_eLife_Byczkowicz.pdf
  file_size: 4008137
  relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
  eissn:
  - 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: HCN channel-mediated neuromodulation can control action potential velocity
  and fidelity in central axons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2019'
...
---
_id: '6877'
article_processing_charge: No
article_type: original
author:
- first_name: Aglaja
  full_name: Kopf, Aglaja
  id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
  last_name: Kopf
  orcid: 0000-0002-2187-6656
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Kopf A, Sixt MK. The neural crest pitches in to remove apoptotic debris. <i>Cell</i>.
    2019;179(1):51-53. doi:<a href="https://doi.org/10.1016/j.cell.2019.08.047">10.1016/j.cell.2019.08.047</a>
  apa: Kopf, A., &#38; Sixt, M. K. (2019). The neural crest pitches in to remove apoptotic
    debris. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2019.08.047">https://doi.org/10.1016/j.cell.2019.08.047</a>
  chicago: Kopf, Aglaja, and Michael K Sixt. “The Neural Crest Pitches in to Remove
    Apoptotic Debris.” <i>Cell</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.cell.2019.08.047">https://doi.org/10.1016/j.cell.2019.08.047</a>.
  ieee: A. Kopf and M. K. Sixt, “The neural crest pitches in to remove apoptotic debris,”
    <i>Cell</i>, vol. 179, no. 1. Elsevier, pp. 51–53, 2019.
  ista: Kopf A, Sixt MK. 2019. The neural crest pitches in to remove apoptotic debris.
    Cell. 179(1), 51–53.
  mla: Kopf, Aglaja, and Michael K. Sixt. “The Neural Crest Pitches in to Remove Apoptotic
    Debris.” <i>Cell</i>, vol. 179, no. 1, Elsevier, 2019, pp. 51–53, doi:<a href="https://doi.org/10.1016/j.cell.2019.08.047">10.1016/j.cell.2019.08.047</a>.
  short: A. Kopf, M.K. Sixt, Cell 179 (2019) 51–53.
date_created: 2019-09-15T22:00:46Z
date_published: 2019-09-19T00:00:00Z
date_updated: 2024-03-25T23:30:22Z
day: '19'
department:
- _id: MiSi
doi: 10.1016/j.cell.2019.08.047
external_id:
  isi:
  - '000486618500011'
  pmid:
  - '31539498'
intvolume: '       179'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa_version: None
page: 51-53
pmid: 1
publication: Cell
publication_identifier:
  eissn:
  - 1097-4172
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '6891'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: The neural crest pitches in to remove apoptotic debris
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 179
year: '2019'
...
---
_id: '6884'
abstract:
- lang: eng
  text: 'In two-player games on graphs, the players move a token through a graph to
    produce a finite or infinite path, which determines the qualitative winner or
    quantitative payoff of the game. We study bidding games in which the players bid
    for the right to move the token. Several bidding rules were studied previously.
    In Richman bidding, in each round, the players simultaneously submit bids, and
    the higher bidder moves the token and pays the other player. Poorman bidding is
    similar except that the winner of the bidding pays the "bank" rather than the
    other player. Taxman bidding spans the spectrum between Richman and poorman bidding.
    They are parameterized by a constant tau in [0,1]: portion tau of the winning
    bid is paid to the other player, and portion 1-tau to the bank. While finite-duration
    (reachability) taxman games have been studied before, we present, for the first
    time, results on infinite-duration taxman games. It was previously shown that
    both Richman and poorman infinite-duration games with qualitative objectives reduce
    to reachability games, and we show a similar result here. Our most interesting
    results concern quantitative taxman games, namely mean-payoff games, where poorman
    and Richman bidding differ significantly. A central quantity in these games is
    the ratio between the two players'' initial budgets. While in poorman mean-payoff
    games, the optimal payoff of a player depends on the initial ratio, in Richman
    bidding, the payoff depends only on the structure of the game. In both games the
    optimal payoffs can be found using (different) probabilistic connections with
    random-turn games in which in each turn, instead of bidding, a coin is tossed
    to determine which player moves. While the value with Richman bidding equals the
    value of a random-turn game with an un-biased coin, with poorman bidding, the
    bias in the coin is the initial ratio of the budgets. We give a complete classification
    of mean-payoff taxman games that is based on a probabilistic connection: the value
    of a taxman bidding game with parameter tau and initial ratio r, equals the value
    of a random-turn game that uses a coin with bias F(tau, r) = (r+tau * (1-r))/(1+tau).
    Thus, we show that Richman bidding is the exception; namely, for every tau <1,
    the value of the game depends on the initial ratio. Our proof technique simplifies
    and unifies the previous proof techniques for both Richman and poorman bidding. '
alternative_title:
- LIPIcs
article_number: '11'
arxiv: 1
author:
- first_name: Guy
  full_name: Avni, Guy
  id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
  last_name: Avni
  orcid: 0000-0001-5588-8287
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
citation:
  ama: 'Avni G, Henzinger TA, Zikelic D. Bidding mechanisms in graph games. In: Vol
    138. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2019. doi:<a href="https://doi.org/10.4230/LIPICS.MFCS.2019.11">10.4230/LIPICS.MFCS.2019.11</a>'
  apa: 'Avni, G., Henzinger, T. A., &#38; Zikelic, D. (2019). Bidding mechanisms in
    graph games (Vol. 138). Presented at the MFCS: nternational Symposium on Mathematical
    Foundations of Computer Science, Aachen, Germany: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPICS.MFCS.2019.11">https://doi.org/10.4230/LIPICS.MFCS.2019.11</a>'
  chicago: Avni, Guy, Thomas A Henzinger, and Dorde Zikelic. “Bidding Mechanisms in
    Graph Games,” Vol. 138. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019.
    <a href="https://doi.org/10.4230/LIPICS.MFCS.2019.11">https://doi.org/10.4230/LIPICS.MFCS.2019.11</a>.
  ieee: 'G. Avni, T. A. Henzinger, and D. Zikelic, “Bidding mechanisms in graph games,”
    presented at the MFCS: nternational Symposium on Mathematical Foundations of Computer
    Science, Aachen, Germany, 2019, vol. 138.'
  ista: 'Avni G, Henzinger TA, Zikelic D. 2019. Bidding mechanisms in graph games.
    MFCS: nternational Symposium on Mathematical Foundations of Computer Science,
    LIPIcs, vol. 138, 11.'
  mla: Avni, Guy, et al. <i>Bidding Mechanisms in Graph Games</i>. Vol. 138, 11, Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2019, doi:<a href="https://doi.org/10.4230/LIPICS.MFCS.2019.11">10.4230/LIPICS.MFCS.2019.11</a>.
  short: G. Avni, T.A. Henzinger, D. Zikelic, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2019.
conference:
  end_date: 2019-08-30
  location: Aachen, Germany
  name: 'MFCS: nternational Symposium on Mathematical Foundations of Computer Science'
  start_date: 2019-08-26
date_created: 2019-09-18T08:04:26Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-08-07T14:08:34Z
day: '01'
ddc:
- '004'
department:
- _id: ToHe
- _id: KrCh
doi: 10.4230/LIPICS.MFCS.2019.11
ec_funded: 1
external_id:
  arxiv:
  - '1905.03835'
file:
- access_level: open_access
  checksum: 6346e116a4f4ed1414174d96d2c4fbd7
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-09-27T11:45:15Z
  date_updated: 2020-07-14T12:47:42Z
  file_id: '6913'
  file_name: 2019_LIPIcs_Avni.pdf
  file_size: 554457
  relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: '       138'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 264B3912-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02369
  name: Formal Methods meets Algorithmic Game Theory
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11402-N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
  record:
  - id: '9239'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Bidding mechanisms in graph games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 138
year: '2019'
...
---
_id: '6885'
abstract:
- lang: eng
  text: 'A vector addition system with states (VASS) consists of a finite set of states
    and counters. A configuration is a state and a value for each counter; a transition
    changes the state and each counter is incremented, decremented, or left unchanged.
    While qualitative properties such as state and configuration reachability have
    been studied for VASS, we consider the long-run average cost of infinite computations
    of VASS. The cost of a configuration is for each state, a linear combination of
    the counter values. In the special case of uniform cost functions, the linear
    combination is the same for all states. The (regular) long-run emptiness problem
    is, given a VASS, a cost function, and a threshold value, if there is a (lasso-shaped)
    computation such that the long-run average value of the cost function does not
    exceed the threshold. For uniform cost functions, we show that the regular long-run
    emptiness problem is (a) decidable in polynomial time for integer-valued VASS,
    and (b) decidable but nonelementarily hard for natural-valued VASS (i.e., nonnegative
    counters). For general cost functions, we show that the problem is (c) NP-complete
    for integer-valued VASS, and (d) undecidable for natural-valued VASS. Our most
    interesting result is for (c) integer-valued VASS with general cost functions,
    where we establish a connection between the regular long-run emptiness problem
    and quadratic Diophantine inequalities. The general (nonregular) long-run emptiness
    problem is equally hard as the regular problem in all cases except (c), where
    it remains open. '
alternative_title:
- LIPIcs
article_number: '27'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Jan
  full_name: Otop, Jan
  last_name: Otop
citation:
  ama: 'Chatterjee K, Henzinger TA, Otop J. Long-run average behavior of vector addition
    systems with states. In: Vol 140. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2019. doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.27">10.4230/LIPICS.CONCUR.2019.27</a>'
  apa: 'Chatterjee, K., Henzinger, T. A., &#38; Otop, J. (2019). Long-run average
    behavior of vector addition systems with states (Vol. 140). Presented at the CONCUR:
    International Conference on Concurrency Theory, Amsterdam, Netherlands: Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.27">https://doi.org/10.4230/LIPICS.CONCUR.2019.27</a>'
  chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Jan Otop. “Long-Run Average
    Behavior of Vector Addition Systems with States,” Vol. 140. Schloss Dagstuhl -
    Leibniz-Zentrum für Informatik, 2019. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.27">https://doi.org/10.4230/LIPICS.CONCUR.2019.27</a>.
  ieee: 'K. Chatterjee, T. A. Henzinger, and J. Otop, “Long-run average behavior of
    vector addition systems with states,” presented at the CONCUR: International Conference
    on Concurrency Theory, Amsterdam, Netherlands, 2019, vol. 140.'
  ista: 'Chatterjee K, Henzinger TA, Otop J. 2019. Long-run average behavior of vector
    addition systems with states. CONCUR: International Conference on Concurrency
    Theory, LIPIcs, vol. 140, 27.'
  mla: Chatterjee, Krishnendu, et al. <i>Long-Run Average Behavior of Vector Addition
    Systems with States</i>. Vol. 140, 27, Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik, 2019, doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.27">10.4230/LIPICS.CONCUR.2019.27</a>.
  short: K. Chatterjee, T.A. Henzinger, J. Otop, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2019.
conference:
  end_date: 2019-08-30
  location: Amsterdam, Netherlands
  name: 'CONCUR: International Conference on Concurrency Theory'
  start_date: 2019-08-27
date_created: 2019-09-18T08:06:14Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:09:27Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
- _id: KrCh
doi: 10.4230/LIPICS.CONCUR.2019.27
file:
- access_level: open_access
  checksum: 4985e26e1572d1575d64d38acabd71d6
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-09-27T12:09:35Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6914'
  file_name: 2019_LIPIcs_Chatterjee.pdf
  file_size: 538120
  relation: main_file
file_date_updated: 2020-07-14T12:47:43Z
has_accepted_license: '1'
intvolume: '       140'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11402-N23
  name: Rigorous Systems Engineering
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: 1
status: public
title: Long-run average behavior of vector addition systems with states
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 140
year: '2019'
...
---
_id: '6886'
abstract:
- lang: eng
  text: 'In two-player games on graphs, the players move a token through a graph to
    produce an infinite path, which determines the winner of the game. Such games
    are central in formal methods since they model the interaction between a non-terminating
    system and its environment. In bidding games the players bid for the right to
    move the token: in each round, the players simultaneously submit bids, and the
    higher bidder moves the token and pays the other player. Bidding games are known
    to have a clean and elegant mathematical structure that relies on the ability
    of the players to submit arbitrarily small bids. Many applications, however, require
    a fixed granularity for the bids, which can represent, for example, the monetary
    value expressed in cents. We study, for the first time, the combination of discrete-bidding
    and infinite-duration games. Our most important result proves that these games
    form a large determined subclass of concurrent games, where determinacy is the
    strong property that there always exists exactly one player who can guarantee
    winning the game. In particular, we show that, in contrast to non-discrete bidding
    games, the mechanism with which tied bids are resolved plays an important role
    in discrete-bidding games. We study several natural tie-breaking mechanisms and
    show that, while some do not admit determinacy, most natural mechanisms imply
    determinacy for every pair of initial budgets. '
alternative_title:
- LIPIcs
article_number: '20'
article_processing_charge: No
arxiv: 1
author:
- first_name: Milad
  full_name: Aghajohari, Milad
  last_name: Aghajohari
- first_name: Guy
  full_name: Avni, Guy
  id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
  last_name: Avni
  orcid: 0000-0001-5588-8287
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Aghajohari M, Avni G, Henzinger TA. Determinacy in discrete-bidding infinite-duration
    games. In: Vol 140. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2019. doi:<a
    href="https://doi.org/10.4230/LIPICS.CONCUR.2019.20">10.4230/LIPICS.CONCUR.2019.20</a>'
  apa: 'Aghajohari, M., Avni, G., &#38; Henzinger, T. A. (2019). Determinacy in discrete-bidding
    infinite-duration games (Vol. 140). Presented at the CONCUR: International Conference
    on Concurrency Theory, Amsterdam, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.20">https://doi.org/10.4230/LIPICS.CONCUR.2019.20</a>'
  chicago: Aghajohari, Milad, Guy Avni, and Thomas A Henzinger. “Determinacy in Discrete-Bidding
    Infinite-Duration Games,” Vol. 140. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2019. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.20">https://doi.org/10.4230/LIPICS.CONCUR.2019.20</a>.
  ieee: 'M. Aghajohari, G. Avni, and T. A. Henzinger, “Determinacy in discrete-bidding
    infinite-duration games,” presented at the CONCUR: International Conference on
    Concurrency Theory, Amsterdam, Netherlands, 2019, vol. 140.'
  ista: 'Aghajohari M, Avni G, Henzinger TA. 2019. Determinacy in discrete-bidding
    infinite-duration games. CONCUR: International Conference on Concurrency Theory,
    LIPIcs, vol. 140, 20.'
  mla: Aghajohari, Milad, et al. <i>Determinacy in Discrete-Bidding Infinite-Duration
    Games</i>. Vol. 140, 20, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019,
    doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.20">10.4230/LIPICS.CONCUR.2019.20</a>.
  short: M. Aghajohari, G. Avni, T.A. Henzinger, in:, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2019.
conference:
  end_date: 2019-08-30
  location: Amsterdam, Netherlands
  name: 'CONCUR: International Conference on Concurrency Theory'
  start_date: 2019-08-27
date_created: 2019-09-18T08:06:58Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2022-01-26T08:27:10Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.4230/LIPICS.CONCUR.2019.20
external_id:
  arxiv:
  - '1905.03588'
file:
- access_level: open_access
  checksum: 4df6d3575c506edb17215adada03cc8e
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-09-27T12:21:38Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6915'
  file_name: 2019_LIPIcs_Aghajohari.pdf
  file_size: 741425
  relation: main_file
file_date_updated: 2020-07-14T12:47:43Z
has_accepted_license: '1'
intvolume: '       140'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/3.0/
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11402-N23
  name: Rigorous Systems Engineering
- _id: 264B3912-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02369
  name: Formal Methods meets Algorithmic Game Theory
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Determinacy in discrete-bidding infinite-duration games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/3.0/legalcode
  name: Creative Commons Attribution 3.0 Unported (CC BY 3.0)
  short: CC BY (3.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 140
year: '2019'
...
---
_id: '6887'
abstract:
- lang: eng
  text: 'The fundamental model-checking problem, given as input a model and a specification,
    asks for the algorithmic verification of whether the model satisfies the specification.
    Two classical models for reactive systems are graphs and Markov decision processes
    (MDPs). A basic specification formalism in the verification of reactive systems
    is the strong fairness (aka Streett) objective, where given different types of
    requests and corresponding grants, the requirement is that for each type, if the
    request event happens infinitely often, then the corresponding grant event must
    also happen infinitely often. All omega-regular objectives can be expressed as
    Streett objectives and hence they are canonical in verification. Consider graphs/MDPs
    with n vertices, m edges, and a Streett objectives with k pairs, and let b denote
    the size of the description of the Streett objective for the sets of requests
    and grants. The current best-known algorithm for the problem requires time O(min(n^2,
    m sqrt{m log n}) + b log n). In this work we present randomized near-linear time
    algorithms, with expected running time O~(m + b), where the O~ notation hides
    poly-log factors. Our randomized algorithms are near-linear in the size of the
    input, and hence optimal up to poly-log factors. '
alternative_title:
- LIPIcs
article_number: '7'
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Wolfgang
  full_name: Dvorák, Wolfgang
  last_name: Dvorák
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Alexander
  full_name: Svozil, Alexander
  last_name: Svozil
citation:
  ama: 'Chatterjee K, Dvorák W, Henzinger MH, Svozil A. Near-linear time algorithms
    for Streett objectives in graphs and MDPs. In: <i>Leibniz International Proceedings
    in Informatics</i>. Vol 140. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2019. doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.7">10.4230/LIPICS.CONCUR.2019.7</a>'
  apa: 'Chatterjee, K., Dvorák, W., Henzinger, M. H., &#38; Svozil, A. (2019). Near-linear
    time algorithms for Streett objectives in graphs and MDPs. In <i>Leibniz International
    Proceedings in Informatics</i> (Vol. 140). Amsterdam, Netherlands: Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.7">https://doi.org/10.4230/LIPICS.CONCUR.2019.7</a>'
  chicago: Chatterjee, Krishnendu, Wolfgang Dvorák, Monika H Henzinger, and Alexander
    Svozil. “Near-Linear Time Algorithms for Streett Objectives in Graphs and MDPs.”
    In <i>Leibniz International Proceedings in Informatics</i>, Vol. 140. Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2019. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.7">https://doi.org/10.4230/LIPICS.CONCUR.2019.7</a>.
  ieee: K. Chatterjee, W. Dvorák, M. H. Henzinger, and A. Svozil, “Near-linear time
    algorithms for Streett objectives in graphs and MDPs,” in <i>Leibniz International
    Proceedings in Informatics</i>, Amsterdam, Netherlands, 2019, vol. 140.
  ista: 'Chatterjee K, Dvorák W, Henzinger MH, Svozil A. 2019. Near-linear time algorithms
    for Streett objectives in graphs and MDPs. Leibniz International Proceedings in
    Informatics. CONCUR: International Conference on Concurrency Theory, LIPIcs, vol.
    140, 7.'
  mla: Chatterjee, Krishnendu, et al. “Near-Linear Time Algorithms for Streett Objectives
    in Graphs and MDPs.” <i>Leibniz International Proceedings in Informatics</i>,
    vol. 140, 7, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019, doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.7">10.4230/LIPICS.CONCUR.2019.7</a>.
  short: K. Chatterjee, W. Dvorák, M.H. Henzinger, A. Svozil, in:, Leibniz International
    Proceedings in Informatics, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2019.
conference:
  end_date: 2019-08-30
  location: Amsterdam, Netherlands
  name: 'CONCUR: International Conference on Concurrency Theory'
  start_date: 2019-08-27
date_created: 2019-09-18T08:07:58Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2022-08-12T10:54:34Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPICS.CONCUR.2019.7
ec_funded: 1
file:
- access_level: open_access
  checksum: e1f0e4061212454574f34a1368d018ec
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T08:20:30Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6922'
  file_name: 2019_LIPIcs_Chatterjee.pdf
  file_size: 730112
  relation: main_file
file_date_updated: 2020-07-14T12:47:43Z
has_accepted_license: '1'
intvolume: '       140'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
publication: Leibniz International Proceedings in Informatics
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Near-linear time algorithms for Streett objectives in graphs and MDPs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
volume: 140
year: '2019'
...
---
_id: '6888'
abstract:
- lang: eng
  text: In this paper, we design novel liquid time-constant recurrent neural networks
    for robotic control, inspired by the brain of the nematode, C. elegans. In the
    worm's nervous system, neurons communicate through nonlinear time-varying synaptic
    links established amongst them by their particular wiring structure. This property
    enables neurons to express liquid time-constants dynamics and therefore allows
    the network to originate complex behaviors with a small number of neurons. We
    identify neuron-pair communication motifs as design operators and use them to
    configure compact neuronal network structures to govern sequential robotic tasks.
    The networks are systematically designed to map the environmental observations
    to motor actions, by their hierarchical topology from sensory neurons, through
    recurrently-wired interneurons, to motor neurons. The networks are then parametrized
    in a supervised-learning scheme by a search-based algorithm. We demonstrate that
    obtained networks realize interpretable dynamics. We evaluate their performance
    in controlling mobile and arm robots, and compare their attributes to other artificial
    neural network-based control agents. Finally, we experimentally show their superior
    resilience to environmental noise, compared to the existing machine learning-based
    methods.
alternative_title:
- ICRA
article_number: '8793840'
article_processing_charge: No
author:
- first_name: Mathias
  full_name: Lechner, Mathias
  id: 3DC22916-F248-11E8-B48F-1D18A9856A87
  last_name: Lechner
- first_name: Ramin
  full_name: Hasani, Ramin
  last_name: Hasani
- first_name: Manuel
  full_name: Zimmer, Manuel
  last_name: Zimmer
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Radu
  full_name: Grosu, Radu
  last_name: Grosu
citation:
  ama: 'Lechner M, Hasani R, Zimmer M, Henzinger TA, Grosu R. Designing worm-inspired
    neural networks for interpretable robotic control. In: <i>Proceedings - IEEE International
    Conference on Robotics and Automation</i>. Vol 2019-May. IEEE; 2019. doi:<a href="https://doi.org/10.1109/icra.2019.8793840">10.1109/icra.2019.8793840</a>'
  apa: 'Lechner, M., Hasani, R., Zimmer, M., Henzinger, T. A., &#38; Grosu, R. (2019).
    Designing worm-inspired neural networks for interpretable robotic control. In
    <i>Proceedings - IEEE International Conference on Robotics and Automation</i>
    (Vol. 2019–May). Montreal, QC, Canada: IEEE. <a href="https://doi.org/10.1109/icra.2019.8793840">https://doi.org/10.1109/icra.2019.8793840</a>'
  chicago: Lechner, Mathias, Ramin Hasani, Manuel Zimmer, Thomas A Henzinger, and
    Radu Grosu. “Designing Worm-Inspired Neural Networks for Interpretable Robotic
    Control.” In <i>Proceedings - IEEE International Conference on Robotics and Automation</i>,
    Vol. 2019–May. IEEE, 2019. <a href="https://doi.org/10.1109/icra.2019.8793840">https://doi.org/10.1109/icra.2019.8793840</a>.
  ieee: M. Lechner, R. Hasani, M. Zimmer, T. A. Henzinger, and R. Grosu, “Designing
    worm-inspired neural networks for interpretable robotic control,” in <i>Proceedings
    - IEEE International Conference on Robotics and Automation</i>, Montreal, QC,
    Canada, 2019, vol. 2019–May.
  ista: 'Lechner M, Hasani R, Zimmer M, Henzinger TA, Grosu R. 2019. Designing worm-inspired
    neural networks for interpretable robotic control. Proceedings - IEEE International
    Conference on Robotics and Automation. ICRA: International Conference on Robotics
    and Automation, ICRA, vol. 2019–May, 8793840.'
  mla: Lechner, Mathias, et al. “Designing Worm-Inspired Neural Networks for Interpretable
    Robotic Control.” <i>Proceedings - IEEE International Conference on Robotics and
    Automation</i>, vol. 2019–May, 8793840, IEEE, 2019, doi:<a href="https://doi.org/10.1109/icra.2019.8793840">10.1109/icra.2019.8793840</a>.
  short: M. Lechner, R. Hasani, M. Zimmer, T.A. Henzinger, R. Grosu, in:, Proceedings
    - IEEE International Conference on Robotics and Automation, IEEE, 2019.
conference:
  end_date: 2019-05-24
  location: Montreal, QC, Canada
  name: 'ICRA: International Conference on Robotics and Automation'
  start_date: 2019-05-20
date_created: 2019-09-18T08:09:51Z
date_published: 2019-05-01T00:00:00Z
date_updated: 2021-01-12T08:09:28Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1109/icra.2019.8793840
file:
- access_level: open_access
  checksum: f5545a6b60c3ffd01feb3613f81d03b6
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-08T17:30:38Z
  date_updated: 2020-10-08T17:30:38Z
  file_id: '8636'
  file_name: 2019_ICRA_Lechner.pdf
  file_size: 3265107
  relation: main_file
  success: 1
file_date_updated: 2020-10-08T17:30:38Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
publication: Proceedings - IEEE International Conference on Robotics and Automation
publication_identifier:
  isbn:
  - '9781538660270'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Designing worm-inspired neural networks for interpretable robotic control
type: conference
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 2019-May
year: '2019'
...
---
_id: '6889'
abstract:
- lang: eng
  text: 'We study Markov decision processes and turn-based stochastic games with parity
    conditions. There are three qualitative winning criteria, namely, sure winning,
    which requires all paths to satisfy the condition, almost-sure winning, which
    requires the condition to be satisfied with probability 1, and limit-sure winning,
    which requires the condition to be satisfied with probability arbitrarily close
    to 1. We study the combination of two of these criteria for parity conditions,
    e.g., there are two parity conditions one of which must be won surely, and the
    other almost-surely. The problem has been studied recently by Berthon et al. for
    MDPs with combination of sure and almost-sure winning, under infinite-memory strategies,
    and the problem has been established to be in NP cap co-NP. Even in MDPs there
    is a difference between finite-memory and infinite-memory strategies. Our main
    results for combination of sure and almost-sure winning are as follows: (a) we
    show that for MDPs with finite-memory strategies the problem is in NP cap co-NP;
    (b) we show that for turn-based stochastic games the problem is co-NP-complete,
    both for finite-memory and infinite-memory strategies; and (c) we present algorithmic
    results for the finite-memory case, both for MDPs and turn-based stochastic games,
    by reduction to non-stochastic parity games. In addition we show that all the
    above complexity results also carry over to combination of sure and limit-sure
    winning, and results for all other combinations can be derived from existing results
    in the literature. Thus we present a complete picture for the study of combinations
    of two qualitative winning criteria for parity conditions in MDPs and turn-based
    stochastic games. '
alternative_title:
- LIPIcs
article_number: '6'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Nir
  full_name: Piterman, Nir
  last_name: Piterman
citation:
  ama: 'Chatterjee K, Piterman N. Combinations of Qualitative Winning for Stochastic
    Parity Games. In: Vol 140. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2019. doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.6">10.4230/LIPICS.CONCUR.2019.6</a>'
  apa: 'Chatterjee, K., &#38; Piterman, N. (2019). Combinations of Qualitative Winning
    for Stochastic Parity Games (Vol. 140). Presented at the CONCUR: International
    Conference on Concurrency Theory, Amsterdam, Netherlands: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.6">https://doi.org/10.4230/LIPICS.CONCUR.2019.6</a>'
  chicago: Chatterjee, Krishnendu, and Nir Piterman. “Combinations of Qualitative
    Winning for Stochastic Parity Games,” Vol. 140. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2019. <a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.6">https://doi.org/10.4230/LIPICS.CONCUR.2019.6</a>.
  ieee: 'K. Chatterjee and N. Piterman, “Combinations of Qualitative Winning for Stochastic
    Parity Games,” presented at the CONCUR: International Conference on Concurrency
    Theory, Amsterdam, Netherlands, 2019, vol. 140.'
  ista: 'Chatterjee K, Piterman N. 2019. Combinations of Qualitative Winning for Stochastic
    Parity Games. CONCUR: International Conference on Concurrency Theory, LIPIcs,
    vol. 140, 6.'
  mla: Chatterjee, Krishnendu, and Nir Piterman. <i>Combinations of Qualitative Winning
    for Stochastic Parity Games</i>. Vol. 140, 6, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2019, doi:<a href="https://doi.org/10.4230/LIPICS.CONCUR.2019.6">10.4230/LIPICS.CONCUR.2019.6</a>.
  short: K. Chatterjee, N. Piterman, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2019.
conference:
  end_date: 2019-08-30
  location: Amsterdam, Netherlands
  name: 'CONCUR: International Conference on Concurrency Theory'
  start_date: 2019-08-27
date_created: 2019-09-18T08:11:43Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:09:28Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPICS.CONCUR.2019.6
file:
- access_level: open_access
  checksum: 7b2ecfd4d9d02360308c0ca986fc10a7
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T08:49:45Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6923'
  file_name: 2019_LIPIcs_Chatterjee.pdf
  file_size: 509163
  relation: main_file
file_date_updated: 2020-07-14T12:47:43Z
has_accepted_license: '1'
intvolume: '       140'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: 1
status: public
title: Combinations of Qualitative Winning for Stochastic Parity Games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 140
year: '2019'
...
---
_id: '6890'
abstract:
- lang: eng
  text: Describing the protein interactions that form pleomorphic and asymmetric viruses
    represents a considerable challenge to most structural biology techniques, including
    X-ray crystallography and single particle cryo-electron microscopy. Obtaining
    a detailed understanding of these interactions is nevertheless important, considering
    the number of relevant human pathogens that do not follow strict icosahedral or
    helical symmetry. Cryo-electron tomography and subtomogram averaging methods provide
    structural insights into complex biological environments and are well suited to
    go beyond structures of perfectly symmetric viruses. This chapter discusses recent
    developments showing that cryo-ET and subtomogram averaging can provide high-resolution
    insights into hitherto unknown structural features of pleomorphic and asymmetric
    virus particles. It also describes how these methods have significantly added
    to our understanding of retrovirus capsid assemblies in immature and mature viruses.
    Additional examples of irregular viruses and their associated proteins, whose
    structures have been studied via cryo-ET and subtomogram averaging, further support
    the versatility of these methods.
article_processing_charge: No
author:
- first_name: Martin
  full_name: Obr, Martin
  id: 4741CA5A-F248-11E8-B48F-1D18A9856A87
  last_name: Obr
  orcid: 0000-0003-1756-6564
- first_name: Florian KM
  full_name: Schur, Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
citation:
  ama: 'Obr M, Schur FK. Structural analysis of pleomorphic and asymmetric viruses
    using cryo-electron tomography and subtomogram averaging. In: Rey FA, ed. <i>Complementary
    Strategies to Study Virus Structure and Function</i>. Vol 105. Advances in Virus
    Research. Elsevier; 2019:117-159. doi:<a href="https://doi.org/10.1016/bs.aivir.2019.07.008">10.1016/bs.aivir.2019.07.008</a>'
  apa: Obr, M., &#38; Schur, F. K. (2019). Structural analysis of pleomorphic and
    asymmetric viruses using cryo-electron tomography and subtomogram averaging. In
    F. A. Rey (Ed.), <i>Complementary Strategies to Study Virus Structure and Function</i>
    (Vol. 105, pp. 117–159). Elsevier. <a href="https://doi.org/10.1016/bs.aivir.2019.07.008">https://doi.org/10.1016/bs.aivir.2019.07.008</a>
  chicago: Obr, Martin, and Florian KM Schur. “Structural Analysis of Pleomorphic
    and Asymmetric Viruses Using Cryo-Electron Tomography and Subtomogram Averaging.”
    In <i>Complementary Strategies to Study Virus Structure and Function</i>, edited
    by Félix A. Rey, 105:117–59. Advances in Virus Research. Elsevier, 2019. <a href="https://doi.org/10.1016/bs.aivir.2019.07.008">https://doi.org/10.1016/bs.aivir.2019.07.008</a>.
  ieee: M. Obr and F. K. Schur, “Structural analysis of pleomorphic and asymmetric
    viruses using cryo-electron tomography and subtomogram averaging,” in <i>Complementary
    Strategies to Study Virus Structure and Function</i>, vol. 105, F. A. Rey, Ed.
    Elsevier, 2019, pp. 117–159.
  ista: 'Obr M, Schur FK. 2019.Structural analysis of pleomorphic and asymmetric viruses
    using cryo-electron tomography and subtomogram averaging. In: Complementary Strategies
    to Study Virus Structure and Function. vol. 105, 117–159.'
  mla: Obr, Martin, and Florian KM Schur. “Structural Analysis of Pleomorphic and
    Asymmetric Viruses Using Cryo-Electron Tomography and Subtomogram Averaging.”
    <i>Complementary Strategies to Study Virus Structure and Function</i>, edited
    by Félix A. Rey, vol. 105, Elsevier, 2019, pp. 117–59, doi:<a href="https://doi.org/10.1016/bs.aivir.2019.07.008">10.1016/bs.aivir.2019.07.008</a>.
  short: M. Obr, F.K. Schur, in:, F.A. Rey (Ed.), Complementary Strategies to Study
    Virus Structure and Function, Elsevier, 2019, pp. 117–159.
date_created: 2019-09-18T08:15:37Z
date_published: 2019-08-27T00:00:00Z
date_updated: 2023-08-30T06:56:00Z
day: '27'
department:
- _id: FlSc
doi: 10.1016/bs.aivir.2019.07.008
editor:
- first_name: Félix A.
  full_name: Rey, Félix A.
  last_name: Rey
external_id:
  isi:
  - '000501594500006'
  pmid:
  - '    31522703'
intvolume: '       105'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 117-159
pmid: 1
publication: Complementary Strategies to Study Virus Structure and Function
publication_identifier:
  isbn:
  - '9780128184561'
  issn:
  - 0065-3527
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
series_title: Advances in Virus Research
status: public
title: Structural analysis of pleomorphic and asymmetric viruses using cryo-electron
  tomography and subtomogram averaging
type: book_chapter
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2019'
...
---
_id: '6891'
abstract:
- lang: eng
  text: "While cells of mesenchymal or epithelial origin perform their effector functions
    in a purely anchorage dependent manner, cells derived from the hematopoietic lineage
    are not committed to operate only within a specific niche. Instead, these cells
    are able to function autonomously of the molecular composition in a broad range
    of tissue compartments. By this means, cells of the hematopoietic lineage retain
    the capacity to disseminate into connective tissue and recirculate between organs,
    building the foundation for essential processes such as tissue regeneration or
    immune surveillance. \r\nCells of the immune system, specifically leukocytes,
    are extraordinarily good at performing this task. These cells are able to flexibly
    shift their mode of migration between an adhesion-mediated and an adhesion-independent
    manner, instantaneously accommodating for any changes in molecular composition
    of the external scaffold. The key component driving directed leukocyte migration
    is the chemokine receptor 7, which guides the cell along gradients of chemokine
    ligand. Therefore, the physical destination of migrating leukocytes is purely
    deterministic, i.e. given by global directional cues such as chemokine gradients.
    \r\nNevertheless, these cells typically reside in three-dimensional scaffolds
    of inhomogeneous complexity, raising the question whether cells are able to locally
    discriminate between multiple optional migration routes. Current literature provides
    evidence that leukocytes, specifically dendritic cells, do indeed probe their
    surrounding by virtue of multiple explorative protrusions. However, it remains
    enigmatic how these cells decide which one is the more favorable route to follow
    and what are the key players involved in performing this task. Due to the heterogeneous
    environment of most tissues, and the vast adaptability of migrating leukocytes,
    at this time it is not clear to what extent leukocytes are able to optimize their
    migratory strategy by adapting their level of adhesiveness. And, given the fact
    that leukocyte migration is characterized by branched cell shapes in combination
    with high migration velocities, it is reasonable to assume that these cells require
    fine tuned shape maintenance mechanisms that tightly coordinate protrusion and
    adhesion dynamics in a spatiotemporal manner. \r\nTherefore, this study aimed
    to elucidate how rapidly migrating leukocytes opt for an ideal migratory path
    while maintaining a continuous cell shape and balancing adhesive forces to efficiently
    navigate through complex microenvironments. \r\nThe results of this study unraveled
    a role for the microtubule cytoskeleton in promoting the decision making process
    during path finding and for the first time point towards a microtubule-mediated
    function in cell shape maintenance of highly ramified cells such as dendritic
    cells. Furthermore, we found that migrating low-adhesive leukocytes are able to
    instantaneously adapt to increased tensile load by engaging adhesion receptors.
    This response was only occurring tangential to the substrate while adhesive properties
    in the vertical direction were not increased. As leukocytes are primed for rapid
    migration velocities, these results demonstrate that leukocyte integrins are able
    to confer a high level of traction forces parallel to the cell membrane along
    the direction of migration without wasting energy in gluing the cell to the substrate.
    \r\nThus, the data in the here presented thesis provide new insights into the
    pivotal role of cytoskeletal dynamics and the mechanisms of force transduction
    during leukocyte migration. \r\nThereby the here presented results help to further
    define fundamental principles underlying leukocyte migration and open up potential
    therapeutic avenues of clinical relevance.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Aglaja
  full_name: Kopf, Aglaja
  id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
  last_name: Kopf
  orcid: 0000-0002-2187-6656
citation:
  ama: Kopf A. The implication of cytoskeletal dynamics on leukocyte migration. 2019.
    doi:<a href="https://doi.org/10.15479/AT:ISTA:6891">10.15479/AT:ISTA:6891</a>
  apa: Kopf, A. (2019). <i>The implication of cytoskeletal dynamics on leukocyte migration</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:6891">https://doi.org/10.15479/AT:ISTA:6891</a>
  chicago: Kopf, Aglaja. “The Implication of Cytoskeletal Dynamics on Leukocyte Migration.”
    Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:6891">https://doi.org/10.15479/AT:ISTA:6891</a>.
  ieee: A. Kopf, “The implication of cytoskeletal dynamics on leukocyte migration,”
    Institute of Science and Technology Austria, 2019.
  ista: Kopf A. 2019. The implication of cytoskeletal dynamics on leukocyte migration.
    Institute of Science and Technology Austria.
  mla: Kopf, Aglaja. <i>The Implication of Cytoskeletal Dynamics on Leukocyte Migration</i>.
    Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6891">10.15479/AT:ISTA:6891</a>.
  short: A. Kopf, The Implication of Cytoskeletal Dynamics on Leukocyte Migration,
    Institute of Science and Technology Austria, 2019.
date_created: 2019-09-19T08:19:44Z
date_published: 2019-07-24T00:00:00Z
date_updated: 2023-10-18T08:49:17Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: MiSi
doi: 10.15479/AT:ISTA:6891
file:
- access_level: closed
  checksum: 00d100d6468e31e583051e0a006b640c
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: akopf
  date_created: 2019-10-15T05:28:42Z
  date_updated: 2020-10-17T22:30:03Z
  embargo_to: open_access
  file_id: '6950'
  file_name: Kopf_PhD_Thesis.docx
  file_size: 74735267
  relation: source_file
- access_level: open_access
  checksum: 5d1baa899993ae6ca81aebebe1797000
  content_type: application/pdf
  creator: akopf
  date_created: 2019-10-15T05:28:47Z
  date_updated: 2020-10-17T22:30:03Z
  embargo: 2020-10-16
  file_id: '6951'
  file_name: Kopf_PhD_Thesis1.pdf
  file_size: 52787224
  relation: main_file
file_date_updated: 2020-10-17T22:30:03Z
has_accepted_license: '1'
keyword:
- cell biology
- immunology
- leukocyte
- migration
- microfluidics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '171'
project:
- _id: 265E2996-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W01250-B20
  name: Nano-Analytics of Cellular Systems
publication_identifier:
  eissn:
  - 2663-337X
  isbn:
  - 978-3-99078-002-2
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  link:
  - relation: press_release
    url: https://ist.ac.at/en/news/feeling-like-a-cell/
  record:
  - id: '6328'
    relation: part_of_dissertation
    status: public
  - id: '15'
    relation: part_of_dissertation
    status: public
  - id: '6877'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
title: The implication of cytoskeletal dynamics on leukocyte migration
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6894'
abstract:
- lang: eng
  text: "Hybrid automata combine finite automata and dynamical systems, and model
    the interaction of digital with physical systems. Formal analysis that can guarantee
    the safety of all behaviors or rigorously witness failures, while unsolvable in
    general, has been tackled algorithmically using, e.g., abstraction, bounded model-checking,
    assisted theorem proving.\r\nNevertheless, very few methods have addressed the
    time-unbounded reachability analysis of hybrid automata and, for current sound
    and automatic tools, scalability remains critical. We develop methods for the
    polyhedral abstraction of hybrid automata, which construct coarse overapproximations
    and tightens them incrementally, in a CEGAR fashion. We use template polyhedra,
    i.e., polyhedra whose facets are normal to a given set of directions.\r\nWhile,
    previously, directions were given by the user, we introduce (1) the first method\r\nfor
    computing template directions from spurious counterexamples, so as to generalize
    and\r\neliminate them. The method applies naturally to convex hybrid automata,
    i.e., hybrid\r\nautomata with (possibly non-linear) convex constraints on derivatives
    only, while for linear\r\nODE requires further abstraction. Specifically, we introduce
    (2) the conic abstractions,\r\nwhich, partitioning the state space into appropriate
    (possibly non-uniform) cones, divide\r\ncurvy trajectories into relatively straight
    sections, suitable for polyhedral abstractions.\r\nFinally, we introduce (3) space-time
    interpolation, which, combining interval arithmetic\r\nand template refinement,
    computes appropriate (possibly non-uniform) time partitioning\r\nand template
    directions along spurious trajectories, so as to eliminate them.\r\nWe obtain
    sound and automatic methods for the reachability analysis over dense\r\nand unbounded
    time of convex hybrid automata and hybrid automata with linear ODE.\r\nWe build
    prototype tools and compare—favorably—our methods against the respective\r\nstate-of-the-art
    tools, on several benchmarks."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mirco
  full_name: Giacobbe, Mirco
  id: 3444EA5E-F248-11E8-B48F-1D18A9856A87
  last_name: Giacobbe
  orcid: 0000-0001-8180-0904
citation:
  ama: Giacobbe M. Automatic time-unbounded reachability analysis of hybrid systems.
    2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6894">10.15479/AT:ISTA:6894</a>
  apa: Giacobbe, M. (2019). <i>Automatic time-unbounded reachability analysis of hybrid
    systems</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:6894">https://doi.org/10.15479/AT:ISTA:6894</a>
  chicago: Giacobbe, Mirco. “Automatic Time-Unbounded Reachability Analysis of Hybrid
    Systems.” Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:6894">https://doi.org/10.15479/AT:ISTA:6894</a>.
  ieee: M. Giacobbe, “Automatic time-unbounded reachability analysis of hybrid systems,”
    Institute of Science and Technology Austria, 2019.
  ista: Giacobbe M. 2019. Automatic time-unbounded reachability analysis of hybrid
    systems. Institute of Science and Technology Austria.
  mla: Giacobbe, Mirco. <i>Automatic Time-Unbounded Reachability Analysis of Hybrid
    Systems</i>. Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6894">10.15479/AT:ISTA:6894</a>.
  short: M. Giacobbe, Automatic Time-Unbounded Reachability Analysis of Hybrid Systems,
    Institute of Science and Technology Austria, 2019.
date_created: 2019-09-22T14:08:44Z
date_published: 2019-09-30T00:00:00Z
date_updated: 2023-09-19T09:30:43Z
day: '30'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: ToHe
doi: 10.15479/AT:ISTA:6894
file:
- access_level: open_access
  checksum: 773beaf4a85dc2acc2c12b578fbe1965
  content_type: application/pdf
  creator: mgiacobbe
  date_created: 2019-09-27T14:15:05Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6916'
  file_name: giacobbe_thesis.pdf
  file_size: 4100685
  relation: main_file
- access_level: closed
  checksum: 97f1c3da71feefd27e6e625d32b4c75b
  content_type: application/gzip
  creator: mgiacobbe
  date_created: 2019-09-27T14:22:04Z
  date_updated: 2020-07-14T12:47:43Z
  file_id: '6917'
  file_name: giacobbe_thesis_src.tar.gz
  file_size: 7959732
  relation: source_file
file_date_updated: 2020-07-14T12:47:43Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '132'
publication_identifier:
  eissn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '631'
    relation: part_of_dissertation
    status: public
  - id: '647'
    relation: part_of_dissertation
    status: public
  - id: '140'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
title: Automatic time-unbounded reachability analysis of hybrid systems
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6896'
abstract:
- lang: eng
  text: "Until recently, a great amount of brain studies have been conducted in human
    post mortem tissues, cell lines and model organisms. These researches provided
    useful insights regarding cell-cell interactions occurring in the brain. However,
    such approaches suffer from technical limitations and inaccurate modeling of the
    tissue 3D cytoarchitecture. Importantly, they might lack a human genetic background
    essential for disease modeling. With the development of protocols to generate
    human cerebral organoids, we are now closer to reproducing the early stages of
    human brain development in vitro. As a result, more relevant cell-cell interaction
    studies can be conducted.\r\n\r\nIn this review, we discuss the advantages of
    3D cultures over 2D in modulating brain cell-cell interactions during physiological
    and pathological development, as well as the progress made in developing organoids
    in which neurons, macroglia, microglia and vascularization are present. Finally,
    we debate the limitations of those models and possible future directions."
article_number: '146458'
article_processing_charge: No
article_type: original
author:
- first_name: Bárbara
  full_name: Oliveira, Bárbara
  id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87
  last_name: Oliveira
- first_name: Aysan Çerağ
  full_name: Yahya, Aysan Çerağ
  id: 365A65F8-F248-11E8-B48F-1D18A9856A87
  last_name: Yahya
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Oliveira B, Yahya AÇ, Novarino G. Modeling cell-cell interactions in the brain
    using cerebral organoids. <i>Brain Research</i>. 2019;1724. doi:<a href="https://doi.org/10.1016/j.brainres.2019.146458">10.1016/j.brainres.2019.146458</a>
  apa: Oliveira, B., Yahya, A. Ç., &#38; Novarino, G. (2019). Modeling cell-cell interactions
    in the brain using cerebral organoids. <i>Brain Research</i>. Elsevier. <a href="https://doi.org/10.1016/j.brainres.2019.146458">https://doi.org/10.1016/j.brainres.2019.146458</a>
  chicago: Oliveira, Bárbara, Aysan Çerağ Yahya, and Gaia Novarino. “Modeling Cell-Cell
    Interactions in the Brain Using Cerebral Organoids.” <i>Brain Research</i>. Elsevier,
    2019. <a href="https://doi.org/10.1016/j.brainres.2019.146458">https://doi.org/10.1016/j.brainres.2019.146458</a>.
  ieee: B. Oliveira, A. Ç. Yahya, and G. Novarino, “Modeling cell-cell interactions
    in the brain using cerebral organoids,” <i>Brain Research</i>, vol. 1724. Elsevier,
    2019.
  ista: Oliveira B, Yahya AÇ, Novarino G. 2019. Modeling cell-cell interactions in
    the brain using cerebral organoids. Brain Research. 1724, 146458.
  mla: Oliveira, Bárbara, et al. “Modeling Cell-Cell Interactions in the Brain Using
    Cerebral Organoids.” <i>Brain Research</i>, vol. 1724, 146458, Elsevier, 2019,
    doi:<a href="https://doi.org/10.1016/j.brainres.2019.146458">10.1016/j.brainres.2019.146458</a>.
  short: B. Oliveira, A.Ç. Yahya, G. Novarino, Brain Research 1724 (2019).
date_created: 2019-09-22T22:00:35Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2023-08-30T06:19:49Z
day: '01'
department:
- _id: GaNo
doi: 10.1016/j.brainres.2019.146458
external_id:
  isi:
  - '000491646600033'
  pmid:
  - '31521639'
intvolume: '      1724'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
pmid: 1
publication: Brain Research
publication_identifier:
  eissn:
  - '18726240'
  issn:
  - '00068993'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling cell-cell interactions in the brain using cerebral organoids
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 1724
year: '2019'
...
---
_id: '6897'
abstract:
- lang: eng
  text: The apical hook is a transiently formed structure that plays a protective
    role when the germinating seedling penetrates through the soil towards the surface.
    Crucial for proper bending is the local auxin maxima, which defines the concave
    (inner) side of the hook curvature. As no sign of asymmetric auxin distribution
    has been reported in embryonic hypocotyls prior to hook formation, the question
    of how auxin asymmetry is established in the early phases of seedling germination
    remains largely unanswered. Here, we analyzed the auxin distribution and expression
    of PIN auxin efflux carriers from early phases of germination, and show that bending
    of the root in response to gravity is the crucial initial cue that governs the
    hypocotyl bending required for apical hook formation. Importantly, polar auxin
    transport machinery is established gradually after germination starts as a result
    of tight root-hypocotyl interaction and a proper balance between abscisic acid
    and gibberellins.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We thank Jiri Friml and Phillip Brewer for inspiring discussion
  and for help in preparing the manuscript. This research was supported by the Scientific
  Service Units (SSU) of IST-Austria through resources provided by the Bioimaging
  Facility\r\n(BIF), the Life Science Facility (LSF).\r\nThis work was supported by
  grants from the European Research Council (Starting Independent Research Grant ERC-2007-Stg-
  207362-HCPO to E.B.). J.P. and M.S. received funds from European Regional Development
  Fund-Project ‘Centre for Experimental Plant Biology’ (No. CZ.02.1.01/0.0/0.0/16_019/0000738)."
article_number: dev175919
article_processing_charge: No
article_type: original
author:
- first_name: Qiang
  full_name: Zhu, Qiang
  id: 40A4B9E6-F248-11E8-B48F-1D18A9856A87
  last_name: Zhu
- first_name: Marçal
  full_name: Gallemi, Marçal
  id: 460C6802-F248-11E8-B48F-1D18A9856A87
  last_name: Gallemi
  orcid: 0000-0003-4675-6893
- first_name: Jiří
  full_name: Pospíšil, Jiří
  last_name: Pospíšil
- first_name: Petra
  full_name: Žádníková, Petra
  last_name: Žádníková
- first_name: Miroslav
  full_name: Strnad, Miroslav
  last_name: Strnad
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. Root gravity
    response module guides differential growth determining both root bending and apical
    hook formation in Arabidopsis. <i>Development</i>. 2019;146(17). doi:<a href="https://doi.org/10.1242/dev.175919">10.1242/dev.175919</a>
  apa: Zhu, Q., Gallemi, M., Pospíšil, J., Žádníková, P., Strnad, M., &#38; Benková,
    E. (2019). Root gravity response module guides differential growth determining
    both root bending and apical hook formation in Arabidopsis. <i>Development</i>.
    The Company of Biologists. <a href="https://doi.org/10.1242/dev.175919">https://doi.org/10.1242/dev.175919</a>
  chicago: Zhu, Qiang, Marçal Gallemi, Jiří Pospíšil, Petra Žádníková, Miroslav Strnad,
    and Eva Benková. “Root Gravity Response Module Guides Differential Growth Determining
    Both Root Bending and Apical Hook Formation in Arabidopsis.” <i>Development</i>.
    The Company of Biologists, 2019. <a href="https://doi.org/10.1242/dev.175919">https://doi.org/10.1242/dev.175919</a>.
  ieee: Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, and E. Benková,
    “Root gravity response module guides differential growth determining both root
    bending and apical hook formation in Arabidopsis,” <i>Development</i>, vol. 146,
    no. 17. The Company of Biologists, 2019.
  ista: Zhu Q, Gallemi M, Pospíšil J, Žádníková P, Strnad M, Benková E. 2019. Root
    gravity response module guides differential growth determining both root bending
    and apical hook formation in Arabidopsis. Development. 146(17), dev175919.
  mla: Zhu, Qiang, et al. “Root Gravity Response Module Guides Differential Growth
    Determining Both Root Bending and Apical Hook Formation in Arabidopsis.” <i>Development</i>,
    vol. 146, no. 17, dev175919, The Company of Biologists, 2019, doi:<a href="https://doi.org/10.1242/dev.175919">10.1242/dev.175919</a>.
  short: Q. Zhu, M. Gallemi, J. Pospíšil, P. Žádníková, M. Strnad, E. Benková, Development
    146 (2019).
date_created: 2019-09-22T22:00:36Z
date_published: 2019-09-12T00:00:00Z
date_updated: 2025-05-07T11:10:55Z
day: '12'
department:
- _id: EvBe
doi: 10.1242/dev.175919
ec_funded: 1
external_id:
  isi:
  - '000486297400011'
  pmid:
  - '31391194'
intvolume: '       146'
isi: 1
issue: '17'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1242/dev.175919
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '207362'
  name: Hormonal cross-talk in plant organogenesis
publication: Development
publication_identifier:
  eissn:
  - '14779129'
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Root gravity response module guides differential growth determining both root
  bending and apical hook formation in Arabidopsis
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 146
year: '2019'
...
---
_id: '6898'
abstract:
- lang: eng
  text: "Background\r\n\r\nChlamydia are ancient intracellular pathogens with reduced,
    though strikingly conserved genome. Despite their parasitic lifestyle and isolated
    intracellular environment, these bacteria managed to avoid accumulation of deleterious
    mutations leading to subsequent genome degradation characteristic for many parasitic
    bacteria.\r\nResults\r\n\r\nWe report pan-genomic analysis of sixteen species
    from genus Chlamydia including identification and functional annotation of orthologous
    genes, and characterization of gene gains, losses, and rearrangements. We demonstrate
    the overall genome stability of these bacteria as indicated by a large fraction
    of common genes with conserved genomic locations. On the other hand, extreme evolvability
    is confined to several paralogous gene families such as polymorphic membrane proteins
    and phospholipase D, and likely is caused by the pressure from the host immune
    system.\r\nConclusions\r\n\r\nThis combination of a large, conserved core genome
    and a small, evolvable periphery likely reflect the balance between the selective
    pressure towards genome reduction and the need to adapt to escape from the host
    immunity."
article_number: '710'
article_processing_charge: No
author:
- first_name: Olga M.
  full_name: Sigalova, Olga M.
  last_name: Sigalova
- first_name: Andrei V.
  full_name: Chaplin, Andrei V.
  last_name: Chaplin
- first_name: Olga
  full_name: Bochkareva, Olga
  id: C4558D3C-6102-11E9-A62E-F418E6697425
  last_name: Bochkareva
  orcid: 0000-0003-1006-6639
- first_name: Pavel V.
  full_name: Shelyakin, Pavel V.
  last_name: Shelyakin
- first_name: Vsevolod A.
  full_name: Filaretov, Vsevolod A.
  last_name: Filaretov
- first_name: Evgeny E.
  full_name: Akkuratov, Evgeny E.
  last_name: Akkuratov
- first_name: Valentina
  full_name: Burskaia, Valentina
  last_name: Burskaia
- first_name: Mikhail S.
  full_name: Gelfand, Mikhail S.
  last_name: Gelfand
citation:
  ama: Sigalova OM, Chaplin AV, Bochkareva O, et al. Chlamydia pan-genomic analysis
    reveals balance between host adaptation and selective pressure to genome reduction.
    <i>BMC Genomics</i>. 2019;20(1). doi:<a href="https://doi.org/10.1186/s12864-019-6059-5">10.1186/s12864-019-6059-5</a>
  apa: Sigalova, O. M., Chaplin, A. V., Bochkareva, O., Shelyakin, P. V., Filaretov,
    V. A., Akkuratov, E. E., … Gelfand, M. S. (2019). Chlamydia pan-genomic analysis
    reveals balance between host adaptation and selective pressure to genome reduction.
    <i>BMC Genomics</i>. BioMed Central. <a href="https://doi.org/10.1186/s12864-019-6059-5">https://doi.org/10.1186/s12864-019-6059-5</a>
  chicago: Sigalova, Olga M., Andrei V. Chaplin, Olga Bochkareva, Pavel V. Shelyakin,
    Vsevolod A. Filaretov, Evgeny E. Akkuratov, Valentina Burskaia, and Mikhail S.
    Gelfand. “Chlamydia Pan-Genomic Analysis Reveals Balance between Host Adaptation
    and Selective Pressure to Genome Reduction.” <i>BMC Genomics</i>. BioMed Central,
    2019. <a href="https://doi.org/10.1186/s12864-019-6059-5">https://doi.org/10.1186/s12864-019-6059-5</a>.
  ieee: O. M. Sigalova <i>et al.</i>, “Chlamydia pan-genomic analysis reveals balance
    between host adaptation and selective pressure to genome reduction,” <i>BMC Genomics</i>,
    vol. 20, no. 1. BioMed Central, 2019.
  ista: Sigalova OM, Chaplin AV, Bochkareva O, Shelyakin PV, Filaretov VA, Akkuratov
    EE, Burskaia V, Gelfand MS. 2019. Chlamydia pan-genomic analysis reveals balance
    between host adaptation and selective pressure to genome reduction. BMC Genomics.
    20(1), 710.
  mla: Sigalova, Olga M., et al. “Chlamydia Pan-Genomic Analysis Reveals Balance between
    Host Adaptation and Selective Pressure to Genome Reduction.” <i>BMC Genomics</i>,
    vol. 20, no. 1, 710, BioMed Central, 2019, doi:<a href="https://doi.org/10.1186/s12864-019-6059-5">10.1186/s12864-019-6059-5</a>.
  short: O.M. Sigalova, A.V. Chaplin, O. Bochkareva, P.V. Shelyakin, V.A. Filaretov,
    E.E. Akkuratov, V. Burskaia, M.S. Gelfand, BMC Genomics 20 (2019).
date_created: 2019-09-22T22:00:36Z
date_published: 2019-09-12T00:00:00Z
date_updated: 2023-08-30T06:20:22Z
day: '12'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1186/s12864-019-6059-5
external_id:
  isi:
  - '000485256100001'
file:
- access_level: open_access
  checksum: b798773c5823012d31c812c9f7975da2
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T10:33:17Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6924'
  file_name: 2019_BioMed_Sigalova.pdf
  file_size: 4157175
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '        20'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: BMC Genomics
publication_identifier:
  eissn:
  - '14712164'
publication_status: published
publisher: BioMed Central
quality_controlled: '1'
related_material:
  record:
  - id: '9731'
    relation: research_data
    status: public
  - id: '9783'
    relation: research_data
    status: public
  - id: '9890'
    relation: research_data
    status: public
  - id: '9892'
    relation: research_data
    status: public
  - id: '9893'
    relation: research_data
    status: public
  - id: '9894'
    relation: research_data
    status: public
  - id: '9895'
    relation: research_data
    status: public
  - id: '9896'
    relation: research_data
    status: public
  - id: '9897'
    relation: research_data
    status: public
  - id: '9898'
    relation: research_data
    status: public
  - id: '9899'
    relation: research_data
    status: public
  - id: '9900'
    relation: research_data
    status: public
  - id: '9901'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Chlamydia pan-genomic analysis reveals balance between host adaptation and
  selective pressure to genome reduction
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2019'
...
---
_id: '6899'
abstract:
- lang: eng
  text: Intra-organ communication guides morphogenetic processes that are essential
    for an organ to carry out complex physiological functions. In the heart, the growth
    of the myocardium is tightly coupled to that of the endocardium, a specialized
    endothelial tissue that lines its interior. Several molecular pathways have been
    implicated in the communication between these tissues including secreted factors,
    components of the extracellular matrix, or proteins involved in cell-cell communication.
    Yet, it is unknown how the growth of the endocardium is coordinated with that
    of the myocardium. Here, we show that an increased expansion of the myocardial
    atrial chamber volume generates higher junctional forces within endocardial cells.
    This leads to biomechanical signaling involving VE-cadherin, triggering nuclear
    localization of the Hippo pathway transcriptional regulator Yap1 and endocardial
    proliferation. Our work suggests that the growth of the endocardium results from
    myocardial chamber volume expansion and ends when the tension on the tissue is
    relaxed.
article_processing_charge: No
author:
- first_name: Dorothee
  full_name: Bornhorst, Dorothee
  last_name: Bornhorst
- first_name: Peng
  full_name: Xia, Peng
  id: 4AB6C7D0-F248-11E8-B48F-1D18A9856A87
  last_name: Xia
  orcid: 0000-0002-5419-7756
- first_name: Hiroyuki
  full_name: Nakajima, Hiroyuki
  last_name: Nakajima
- first_name: Chaitanya
  full_name: Dingare, Chaitanya
  last_name: Dingare
- first_name: Wiebke
  full_name: Herzog, Wiebke
  last_name: Herzog
- first_name: Virginie
  full_name: Lecaudey, Virginie
  last_name: Lecaudey
- first_name: Naoki
  full_name: Mochizuki, Naoki
  last_name: Mochizuki
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Deborah
  full_name: Yelon, Deborah
  last_name: Yelon
- first_name: Salim
  full_name: Abdelilah-Seyfried, Salim
  last_name: Abdelilah-Seyfried
citation:
  ama: Bornhorst D, Xia P, Nakajima H, et al. Biomechanical signaling within the developing
    zebrafish heart attunes endocardial growth to myocardial chamber dimensions. <i>Nature
    communications</i>. 2019;10(1):4113. doi:<a href="https://doi.org/10.1038/s41467-019-12068-x">10.1038/s41467-019-12068-x</a>
  apa: Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V.,
    … Abdelilah-Seyfried, S. (2019). Biomechanical signaling within the developing
    zebrafish heart attunes endocardial growth to myocardial chamber dimensions. <i>Nature
    Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-019-12068-x">https://doi.org/10.1038/s41467-019-12068-x</a>
  chicago: Bornhorst, Dorothee, Peng Xia, Hiroyuki Nakajima, Chaitanya Dingare, Wiebke
    Herzog, Virginie Lecaudey, Naoki Mochizuki, Carl-Philipp J Heisenberg, Deborah
    Yelon, and Salim Abdelilah-Seyfried. “Biomechanical Signaling within the Developing
    Zebrafish Heart Attunes Endocardial Growth to Myocardial Chamber Dimensions.”
    <i>Nature Communications</i>. Nature Publishing Group, 2019. <a href="https://doi.org/10.1038/s41467-019-12068-x">https://doi.org/10.1038/s41467-019-12068-x</a>.
  ieee: D. Bornhorst <i>et al.</i>, “Biomechanical signaling within the developing
    zebrafish heart attunes endocardial growth to myocardial chamber dimensions,”
    <i>Nature communications</i>, vol. 10, no. 1. Nature Publishing Group, p. 4113,
    2019.
  ista: Bornhorst D, Xia P, Nakajima H, Dingare C, Herzog W, Lecaudey V, Mochizuki
    N, Heisenberg C-PJ, Yelon D, Abdelilah-Seyfried S. 2019. Biomechanical signaling
    within the developing zebrafish heart attunes endocardial growth to myocardial
    chamber dimensions. Nature communications. 10(1), 4113.
  mla: Bornhorst, Dorothee, et al. “Biomechanical Signaling within the Developing
    Zebrafish Heart Attunes Endocardial Growth to Myocardial Chamber Dimensions.”
    <i>Nature Communications</i>, vol. 10, no. 1, Nature Publishing Group, 2019, p.
    4113, doi:<a href="https://doi.org/10.1038/s41467-019-12068-x">10.1038/s41467-019-12068-x</a>.
  short: D. Bornhorst, P. Xia, H. Nakajima, C. Dingare, W. Herzog, V. Lecaudey, N.
    Mochizuki, C.-P.J. Heisenberg, D. Yelon, S. Abdelilah-Seyfried, Nature Communications
    10 (2019) 4113.
date_created: 2019-09-22T22:00:37Z
date_published: 2019-09-11T00:00:00Z
date_updated: 2023-08-30T06:21:23Z
day: '11'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1038/s41467-019-12068-x
external_id:
  isi:
  - '000485216800009'
  pmid:
  - '31511517'
file:
- access_level: open_access
  checksum: 62c2512712e16d27c1797d318d14ba9f
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T11:18:50Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6926'
  file_name: 2019_Nature_Bornhorst.pdf
  file_size: 3905793
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '4113'
pmid: 1
publication: Nature communications
publication_identifier:
  eissn:
  - '20411723'
publication_status: published
publisher: Nature Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Biomechanical signaling within the developing zebrafish heart attunes endocardial
  growth to myocardial chamber dimensions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2019'
...
---
_id: '6900'
abstract:
- lang: eng
  text: Across diverse biological systems—ranging from neural networks to intracellular
    signaling and genetic regulatory networks—the information about changes in the
    environment is frequently encoded in the full temporal dynamics of the network
    nodes. A pressing data-analysis challenge has thus been to efficiently estimate
    the amount of information that these dynamics convey from experimental data. Here
    we develop and evaluate decoding-based estimation methods to lower bound the mutual
    information about a finite set of inputs, encoded in single-cell high-dimensional
    time series data. For biological reaction networks governed by the chemical Master
    equation, we derive model-based information approximations and analytical upper
    bounds, against which we benchmark our proposed model-free decoding estimators.
    In contrast to the frequently-used k-nearest-neighbor estimator, decoding-based
    estimators robustly extract a large fraction of the available information from
    high-dimensional trajectories with a realistic number of data samples. We apply
    these estimators to previously published data on Erk and Ca2+ signaling in mammalian
    cells and to yeast stress-response, and find that substantial amount of information
    about environmental state can be encoded by non-trivial response statistics even
    in stationary signals. We argue that these single-cell, decoding-based information
    estimates, rather than the commonly-used tests for significant differences between
    selected population response statistics, provide a proper and unbiased measure
    for the performance of biological signaling networks.
article_processing_charge: No
author:
- first_name: Sarah A
  full_name: Cepeda Humerez, Sarah A
  id: 3DEE19A4-F248-11E8-B48F-1D18A9856A87
  last_name: Cepeda Humerez
- first_name: Jakob
  full_name: Ruess, Jakob
  last_name: Ruess
  orcid: 0000-0003-1615-3282
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: Cepeda Humerez SA, Ruess J, Tkačik G. Estimating information in time-varying
    signals. <i>PLoS computational biology</i>. 2019;15(9):e1007290. doi:<a href="https://doi.org/10.1371/journal.pcbi.1007290">10.1371/journal.pcbi.1007290</a>
  apa: Cepeda Humerez, S. A., Ruess, J., &#38; Tkačik, G. (2019). Estimating information
    in time-varying signals. <i>PLoS Computational Biology</i>. Public Library of
    Science. <a href="https://doi.org/10.1371/journal.pcbi.1007290">https://doi.org/10.1371/journal.pcbi.1007290</a>
  chicago: Cepeda Humerez, Sarah A, Jakob Ruess, and Gašper Tkačik. “Estimating Information
    in Time-Varying Signals.” <i>PLoS Computational Biology</i>. Public Library of
    Science, 2019. <a href="https://doi.org/10.1371/journal.pcbi.1007290">https://doi.org/10.1371/journal.pcbi.1007290</a>.
  ieee: S. A. Cepeda Humerez, J. Ruess, and G. Tkačik, “Estimating information in
    time-varying signals,” <i>PLoS computational biology</i>, vol. 15, no. 9. Public
    Library of Science, p. e1007290, 2019.
  ista: Cepeda Humerez SA, Ruess J, Tkačik G. 2019. Estimating information in time-varying
    signals. PLoS computational biology. 15(9), e1007290.
  mla: Cepeda Humerez, Sarah A., et al. “Estimating Information in Time-Varying Signals.”
    <i>PLoS Computational Biology</i>, vol. 15, no. 9, Public Library of Science,
    2019, p. e1007290, doi:<a href="https://doi.org/10.1371/journal.pcbi.1007290">10.1371/journal.pcbi.1007290</a>.
  short: S.A. Cepeda Humerez, J. Ruess, G. Tkačik, PLoS Computational Biology 15 (2019)
    e1007290.
date_created: 2019-09-22T22:00:37Z
date_published: 2019-09-03T00:00:00Z
date_updated: 2023-09-07T12:55:21Z
day: '03'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1007290
external_id:
  isi:
  - '000489741800021'
  pmid:
  - '31479447'
file:
- access_level: open_access
  checksum: 81bdce1361c9aa8395d6fa635fb6ab47
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-01T10:53:45Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6925'
  file_name: 2019_PLoS_Cepeda-Humerez.pdf
  file_size: 3081855
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: e1007290
pmid: 1
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28844-B27
  name: Biophysics of information processing in gene regulation
publication: PLoS computational biology
publication_identifier:
  eissn:
  - '15537358'
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
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  - id: '6473'
    relation: part_of_dissertation
    status: public
scopus_import: '1'
status: public
title: Estimating information in time-varying signals
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 15
year: '2019'
...
---
_id: '6919'
article_number: eaaw6490
article_processing_charge: No
author:
- first_name: Chao
  full_name: Qi, Chao
  last_name: Qi
- first_name: Giulio Di
  full_name: Minin, Giulio Di
  last_name: Minin
- first_name: Irene
  full_name: Vercellino, Irene
  id: 3ED6AF16-F248-11E8-B48F-1D18A9856A87
  last_name: Vercellino
  orcid: 0000-0001-5618-3449
- first_name: Anton
  full_name: Wutz, Anton
  last_name: Wutz
- first_name: Volodymyr M.
  full_name: Korkhov, Volodymyr M.
  last_name: Korkhov
citation:
  ama: Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. Structural basis of sterol
    recognition by human hedgehog receptor PTCH1. <i>Science Advances</i>. 2019;5(9).
    doi:<a href="https://doi.org/10.1126/sciadv.aaw6490">10.1126/sciadv.aaw6490</a>
  apa: Qi, C., Minin, G. D., Vercellino, I., Wutz, A., &#38; Korkhov, V. M. (2019).
    Structural basis of sterol recognition by human hedgehog receptor PTCH1. <i>Science
    Advances</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/sciadv.aaw6490">https://doi.org/10.1126/sciadv.aaw6490</a>
  chicago: Qi, Chao, Giulio Di Minin, Irene Vercellino, Anton Wutz, and Volodymyr
    M. Korkhov. “Structural Basis of Sterol Recognition by Human Hedgehog Receptor
    PTCH1.” <i>Science Advances</i>. American Association for the Advancement of Science,
    2019. <a href="https://doi.org/10.1126/sciadv.aaw6490">https://doi.org/10.1126/sciadv.aaw6490</a>.
  ieee: C. Qi, G. D. Minin, I. Vercellino, A. Wutz, and V. M. Korkhov, “Structural
    basis of sterol recognition by human hedgehog receptor PTCH1,” <i>Science Advances</i>,
    vol. 5, no. 9. American Association for the Advancement of Science, 2019.
  ista: Qi C, Minin GD, Vercellino I, Wutz A, Korkhov VM. 2019. Structural basis of
    sterol recognition by human hedgehog receptor PTCH1. Science Advances. 5(9), eaaw6490.
  mla: Qi, Chao, et al. “Structural Basis of Sterol Recognition by Human Hedgehog
    Receptor PTCH1.” <i>Science Advances</i>, vol. 5, no. 9, eaaw6490, American Association
    for the Advancement of Science, 2019, doi:<a href="https://doi.org/10.1126/sciadv.aaw6490">10.1126/sciadv.aaw6490</a>.
  short: C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances
    5 (2019).
date_created: 2019-09-29T22:00:45Z
date_published: 2019-09-18T00:00:00Z
date_updated: 2023-08-30T06:55:31Z
day: '18'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1126/sciadv.aaw6490
external_id:
  isi:
  - '000491128800062'
file:
- access_level: open_access
  checksum: b2256c9117655bc15f621ba0babf219f
  content_type: application/pdf
  creator: kschuh
  date_created: 2019-10-02T11:13:54Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6928'
  file_name: 2019_AAAS_Qi.pdf
  file_size: 1236101
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '9'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '09'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
  eissn:
  - '23752548'
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structural basis of sterol recognition by human hedgehog receptor PTCH1
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2019'
...
---
_id: '6920'
article_processing_charge: No
article_type: original
author:
- first_name: Christina
  full_name: Artner, Christina
  id: 45DF286A-F248-11E8-B48F-1D18A9856A87
  last_name: Artner
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Artner C, Benková E. Ethylene and cytokinin - partners in root growth regulation.
    <i>Molecular Plant</i>. 2019;12(10):1312-1314. doi:<a href="https://doi.org/10.1016/j.molp.2019.09.003">10.1016/j.molp.2019.09.003</a>
  apa: Artner, C., &#38; Benková, E. (2019). Ethylene and cytokinin - partners in
    root growth regulation. <i>Molecular Plant</i>. Cell Press. <a href="https://doi.org/10.1016/j.molp.2019.09.003">https://doi.org/10.1016/j.molp.2019.09.003</a>
  chicago: Artner, Christina, and Eva Benková. “Ethylene and Cytokinin - Partners
    in Root Growth Regulation.” <i>Molecular Plant</i>. Cell Press, 2019. <a href="https://doi.org/10.1016/j.molp.2019.09.003">https://doi.org/10.1016/j.molp.2019.09.003</a>.
  ieee: C. Artner and E. Benková, “Ethylene and cytokinin - partners in root growth
    regulation,” <i>Molecular Plant</i>, vol. 12, no. 10. Cell Press, pp. 1312–1314,
    2019.
  ista: Artner C, Benková E. 2019. Ethylene and cytokinin - partners in root growth
    regulation. Molecular Plant. 12(10), 1312–1314.
  mla: Artner, Christina, and Eva Benková. “Ethylene and Cytokinin - Partners in Root
    Growth Regulation.” <i>Molecular Plant</i>, vol. 12, no. 10, Cell Press, 2019,
    pp. 1312–14, doi:<a href="https://doi.org/10.1016/j.molp.2019.09.003">10.1016/j.molp.2019.09.003</a>.
  short: C. Artner, E. Benková, Molecular Plant 12 (2019) 1312–1314.
date_created: 2019-09-30T10:00:40Z
date_published: 2019-10-07T00:00:00Z
date_updated: 2023-08-30T06:55:02Z
day: '07'
department:
- _id: EvBe
doi: 10.1016/j.molp.2019.09.003
external_id:
  isi:
  - '000489132500002'
  pmid:
  - '31541740'
intvolume: '        12'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 1312-1314
pmid: 1
project:
- _id: 2685A872-B435-11E9-9278-68D0E5697425
  name: Hormonal regulation of plant adaptive responses to environmental signals
publication: Molecular Plant
publication_identifier:
  issn:
  - 1674-2052
  - 1752-9867
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ethylene and cytokinin - partners in root growth regulation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2019'
...
---
_id: '6931'
abstract:
- lang: eng
  text: "Consider a distributed system with n processors out of which f can be Byzantine
    faulty. In the\r\napproximate agreement task, each processor i receives an input
    value xi and has to decide on an\r\noutput value yi such that\r\n1. the output
    values are in the convex hull of the non-faulty processors’ input values,\r\n2.
    the output values are within distance d of each other.\r\n\r\n\r\nClassically,
    the values are assumed to be from an m-dimensional Euclidean space, where m ≥
    1.\r\nIn this work, we study the task in a discrete setting, where input values
    with some structure\r\nexpressible as a graph. Namely, the input values are vertices
    of a finite graph G and the goal is to\r\noutput vertices that are within distance
    d of each other in G, but still remain in the graph-induced\r\nconvex hull of
    the input values. For d = 0, the task reduces to consensus and cannot be solved
    with\r\na deterministic algorithm in an asynchronous system even with a single
    crash fault. For any d ≥ 1,\r\nwe show that the task is solvable in asynchronous
    systems when G is chordal and n > (ω + 1)f,\r\nwhere ω is the clique number of
    G. In addition, we give the first Byzantine-tolerant algorithm for a\r\nvariant
    of lattice agreement. For synchronous systems, we show tight resilience bounds
    for the exact\r\nvariants of these and related tasks over a large class of combinatorial
    structures."
alternative_title:
- LIPIcs
article_processing_charge: No
arxiv: 1
author:
- first_name: Thomas
  full_name: Nowak, Thomas
  last_name: Nowak
- first_name: Joel
  full_name: Rybicki, Joel
  id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
  last_name: Rybicki
  orcid: 0000-0002-6432-6646
citation:
  ama: 'Nowak T, Rybicki J. Byzantine approximate agreement on graphs. In: <i>33rd
    International Symposium on Distributed Computing</i>. Vol 146. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik; 2019:29:1--29:17. doi:<a href="https://doi.org/10.4230/LIPICS.DISC.2019.29">10.4230/LIPICS.DISC.2019.29</a>'
  apa: 'Nowak, T., &#38; Rybicki, J. (2019). Byzantine approximate agreement on graphs.
    In <i>33rd International Symposium on Distributed Computing</i> (Vol. 146, p.
    29:1--29:17). Budapest, Hungary: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
    <a href="https://doi.org/10.4230/LIPICS.DISC.2019.29">https://doi.org/10.4230/LIPICS.DISC.2019.29</a>'
  chicago: Nowak, Thomas, and Joel Rybicki. “Byzantine Approximate Agreement on Graphs.”
    In <i>33rd International Symposium on Distributed Computing</i>, 146:29:1--29:17.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019. <a href="https://doi.org/10.4230/LIPICS.DISC.2019.29">https://doi.org/10.4230/LIPICS.DISC.2019.29</a>.
  ieee: T. Nowak and J. Rybicki, “Byzantine approximate agreement on graphs,” in <i>33rd
    International Symposium on Distributed Computing</i>, Budapest, Hungary, 2019,
    vol. 146, p. 29:1--29:17.
  ista: 'Nowak T, Rybicki J. 2019. Byzantine approximate agreement on graphs. 33rd
    International Symposium on Distributed Computing. DISC: International Symposium
    on Distributed Computing, LIPIcs, vol. 146, 29:1--29:17.'
  mla: Nowak, Thomas, and Joel Rybicki. “Byzantine Approximate Agreement on Graphs.”
    <i>33rd International Symposium on Distributed Computing</i>, vol. 146, Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2019, p. 29:1--29:17, doi:<a href="https://doi.org/10.4230/LIPICS.DISC.2019.29">10.4230/LIPICS.DISC.2019.29</a>.
  short: T. Nowak, J. Rybicki, in:, 33rd International Symposium on Distributed Computing,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019, p. 29:1--29:17.
conference:
  end_date: 2019-10-18
  location: Budapest, Hungary
  name: 'DISC: International Symposium on Distributed Computing'
  start_date: 2019-10-14
date_created: 2019-10-08T12:41:38Z
date_published: 2019-01-01T00:00:00Z
date_updated: 2021-01-12T08:09:38Z
ddc:
- '004'
department:
- _id: DaAl
doi: 10.4230/LIPICS.DISC.2019.29
ec_funded: 1
external_id:
  arxiv:
  - '1908.02743'
file:
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  checksum: 2d2202f90c6ac991e50876451627c4b5
  content_type: application/pdf
  creator: jrybicki
  date_created: 2019-10-08T12:47:19Z
  date_updated: 2020-07-14T12:47:44Z
  file_id: '6934'
  file_name: LIPIcs-DISC-2019-29.pdf
  file_size: 639378
  relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: '       146'
keyword:
- consensus
- approximate agreement
- Byzantine faults
- chordal graphs
- lattice agreement
language:
- iso: eng
oa: 1
oa_version: Published Version
page: 29:1--29:17
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: 33rd International Symposium on Distributed Computing
publication_identifier:
  eisbn:
  - 978-3-95977-126-9
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: 1
status: public
title: Byzantine approximate agreement on graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 146
year: '2019'
...
