---
_id: '6822'
abstract:
- lang: eng
text: "In two-player games on graphs, the players move a token through a graph to
produce an infinite path, which determines the qualitative winner or quantitative
payoff of the game. In bidding games, in each turn, we hold an auction between
the two players to determine which player moves the token. Bidding games have
largely been studied with concrete bidding mechanisms that are variants of a first-price
auction: in each turn both players simultaneously submit bids, the higher\r\nbidder
moves the token, and pays his bid to the lower bidder in Richman bidding, to the
bank in poorman bidding, and in taxman bidding, the bid is split between the other
player and the bank according to a predefined constant factor. Bidding games are
deterministic games. They have an intriguing connection with a fragment of stochastic
games called \r\n randomturn games. We study, for the first time, a combination
of bidding games with probabilistic behavior; namely, we study bidding games that
are played on Markov decision processes, where the players bid for the right to
choose the next action, which determines the probability distribution according
to which the next vertex is chosen. We study parity and meanpayoff bidding games
on MDPs and extend results from the deterministic bidding setting to the probabilistic
one."
alternative_title:
- LNCS
author:
- first_name: Guy
full_name: Avni, Guy
id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
last_name: Avni
orcid: 0000-0001-5588-8287
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Petr
full_name: Novotny, Petr
last_name: Novotny
citation:
ama: 'Avni G, Henzinger TA, Ibsen-Jensen R, Novotny P. Bidding games on Markov decision
processes. In: Proceedings of the 13th International Conference of Reachability
Problems. Vol 11674. Springer; 2019:1-12. doi:10.1007/978-3-030-30806-3_1'
apa: 'Avni, G., Henzinger, T. A., Ibsen-Jensen, R., & Novotny, P. (2019). Bidding
games on Markov decision processes. In Proceedings of the 13th International
Conference of Reachability Problems (Vol. 11674, pp. 1–12). Brussels, Belgium:
Springer. https://doi.org/10.1007/978-3-030-30806-3_1'
chicago: Avni, Guy, Thomas A Henzinger, Rasmus Ibsen-Jensen, and Petr Novotny. “Bidding
Games on Markov Decision Processes.” In Proceedings of the 13th International
Conference of Reachability Problems, 11674:1–12. Springer, 2019. https://doi.org/10.1007/978-3-030-30806-3_1.
ieee: G. Avni, T. A. Henzinger, R. Ibsen-Jensen, and P. Novotny, “Bidding games
on Markov decision processes,” in Proceedings of the 13th International Conference
of Reachability Problems, Brussels, Belgium, 2019, vol. 11674, pp. 1–12.
ista: 'Avni G, Henzinger TA, Ibsen-Jensen R, Novotny P. 2019. Bidding games on Markov
decision processes. Proceedings of the 13th International Conference of Reachability
Problems. RP: Reachability Problems, LNCS, vol. 11674, 1–12.'
mla: Avni, Guy, et al. “Bidding Games on Markov Decision Processes.” Proceedings
of the 13th International Conference of Reachability Problems, vol. 11674,
Springer, 2019, pp. 1–12, doi:10.1007/978-3-030-30806-3_1.
short: G. Avni, T.A. Henzinger, R. Ibsen-Jensen, P. Novotny, in:, Proceedings of
the 13th International Conference of Reachability Problems, Springer, 2019, pp.
1–12.
conference:
end_date: 2019-09-13
location: Brussels, Belgium
name: 'RP: Reachability Problems'
start_date: 2019-09-11
date_created: 2019-08-19T07:58:10Z
date_published: 2019-09-06T00:00:00Z
date_updated: 2021-01-12T08:09:12Z
day: '06'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-030-30806-3_1
file:
- access_level: open_access
checksum: 45ebbc709af2b247d28c7c293c01504b
content_type: application/pdf
creator: gavni
date_created: 2019-08-19T07:56:40Z
date_updated: 2020-07-14T12:47:41Z
file_id: '6823'
file_name: prob.pdf
file_size: 436635
relation: main_file
file_date_updated: 2020-07-14T12:47:41Z
has_accepted_license: '1'
intvolume: ' 11674'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 1-12
project:
- _id: 264B3912-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02369
name: Formal Methods meets Algorithmic Game Theory
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: ' Proceedings of the 13th International Conference of Reachability Problems'
publication_identifier:
isbn:
- 978-303030805-6
issn:
- 0302-9743
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: 1
status: public
title: Bidding games on Markov decision processes
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11674
year: '2019'
...
---
_id: '6824'
abstract:
- lang: eng
text: Platelets are small anucleate cellular fragments that are released by megakaryocytes
and safeguard vascular integrity through a process termed ‘haemostasis’. However,
platelets have important roles beyond haemostasis as they contribute to the initiation
and coordination of intravascular immune responses. They continuously monitor
blood vessel integrity and tightly coordinate vascular trafficking and functions
of multiple cell types. In this way platelets act as ‘patrolling officers of the
vascular highway’ that help to establish effective immune responses to infections
and cancer. Here we discuss the distinct biological features of platelets that
allow them to shape immune responses to pathogens and tumour cells, highlighting
the parallels between these responses.
article_processing_charge: No
article_type: original
author:
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Steffen
full_name: Massberg, Steffen
last_name: Massberg
citation:
ama: 'Gärtner FR, Massberg S. Patrolling the vascular borders: Platelets in immunity
to infection and cancer. Nature Reviews Immunology. 2019;19(12):747–760.
doi:10.1038/s41577-019-0202-z'
apa: 'Gärtner, F. R., & Massberg, S. (2019). Patrolling the vascular borders:
Platelets in immunity to infection and cancer. Nature Reviews Immunology.
Springer Nature. https://doi.org/10.1038/s41577-019-0202-z'
chicago: 'Gärtner, Florian R, and Steffen Massberg. “Patrolling the Vascular Borders:
Platelets in Immunity to Infection and Cancer.” Nature Reviews Immunology.
Springer Nature, 2019. https://doi.org/10.1038/s41577-019-0202-z.'
ieee: 'F. R. Gärtner and S. Massberg, “Patrolling the vascular borders: Platelets
in immunity to infection and cancer,” Nature Reviews Immunology, vol. 19,
no. 12. Springer Nature, pp. 747–760, 2019.'
ista: 'Gärtner FR, Massberg S. 2019. Patrolling the vascular borders: Platelets
in immunity to infection and cancer. Nature Reviews Immunology. 19(12), 747–760.'
mla: 'Gärtner, Florian R., and Steffen Massberg. “Patrolling the Vascular Borders:
Platelets in Immunity to Infection and Cancer.” Nature Reviews Immunology,
vol. 19, no. 12, Springer Nature, 2019, pp. 747–760, doi:10.1038/s41577-019-0202-z.'
short: F.R. Gärtner, S. Massberg, Nature Reviews Immunology 19 (2019) 747–760.
date_created: 2019-08-20T17:24:32Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2023-08-29T07:16:14Z
day: '01'
department:
- _id: MiSi
doi: 10.1038/s41577-019-0202-z
ec_funded: 1
external_id:
isi:
- '000499090600011'
pmid:
- '31409920'
intvolume: ' 19'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa_version: None
page: 747–760
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Nature Reviews Immunology
publication_identifier:
eissn:
- 1474-1741
issn:
- 1474-1733
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Patrolling the vascular borders: Platelets in immunity to infection and cancer'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2019'
...
---
_id: '6825'
abstract:
- lang: eng
text: "The solving of complex tasks requires the functions of more than one brain
area and their interaction. Whilst spatial navigation and memory is dependent
on the hippocampus, flexible behavior relies on the medial prefrontal cortex (mPFC).
To further examine the roles of the hippocampus and mPFC, we recorded their neural
activity during a task that depends on both of these brain regions.\r\nWith tetrodes,
we recorded the extracellular activity of dorsal hippocampal CA1 (HPC) and mPFC
neurons in Long-Evans rats performing a rule-switching task on the plus-maze.
The plus-maze task had a spatial component since it required navigation along
one of the two start arms and at the maze center a choice between one of the two
goal arms. Which goal contained a reward depended on the rule currently in place.
After an uncued rule change the animal had to abandon the old strategy and switch
to the new rule, testing cognitive flexibility. Investigating the coordination
of activity between the HPC and mPFC allows determination during which task stages
their interaction is required. Additionally, comparing neural activity patterns
in these two brain regions allows delineation of the specialized functions of
the HPC and mPFC in this task. We analyzed neural activity in the HPC and mPFC
in terms of oscillatory interactions, rule coding and replay.\r\nWe found that
theta coherence between the HPC and mPFC is increased at the center and goals
of the maze, both when the rule was stable or has changed. Similar results were
found for locking of HPC and mPFC neurons to HPC theta oscillations. However,
no differences in HPC-mPFC theta coordination were observed between the spatially-
and cue-guided rule. Phase locking of HPC and mPFC neurons to HPC gamma oscillations
was not modulated by\r\nmaze position or rule type. We found that the HPC coded
for the two different rules with cofiring relationships between\r\ncell pairs.
However, we could not find conclusive evidence for rule coding in the mPFC. Spatially-selective
firing in the mPFC generalized between the two start and two goal arms. With Bayesian
positional decoding, we found that the mPFC reactivated non-local positions during
awake immobility periods. Replay of these non-local positions could represent
entire behavioral trajectories resembling trajectory replay of the HPC. Furthermore,
mPFC\r\ntrajectory-replay at the goal positively correlated with rule-switching
performance. \r\nFinally, HPC and mPFC trajectory replay occurred independently
of each other. These results show that the mPFC can replay ordered patterns of
activity during awake immobility, possibly underlying its role in flexible behavior. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
citation:
ama: Käfer K. The hippocampus and medial prefrontal cortex during flexible behavior.
2019. doi:10.15479/AT:ISTA:6825
apa: Käfer, K. (2019). The hippocampus and medial prefrontal cortex during flexible
behavior. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:6825
chicago: Käfer, Karola. “The Hippocampus and Medial Prefrontal Cortex during Flexible
Behavior.” Institute of Science and Technology Austria, 2019. https://doi.org/10.15479/AT:ISTA:6825.
ieee: K. Käfer, “The hippocampus and medial prefrontal cortex during flexible behavior,”
Institute of Science and Technology Austria, 2019.
ista: Käfer K. 2019. The hippocampus and medial prefrontal cortex during flexible
behavior. Institute of Science and Technology Austria.
mla: Käfer, Karola. The Hippocampus and Medial Prefrontal Cortex during Flexible
Behavior. Institute of Science and Technology Austria, 2019, doi:10.15479/AT:ISTA:6825.
short: K. Käfer, The Hippocampus and Medial Prefrontal Cortex during Flexible Behavior,
Institute of Science and Technology Austria, 2019.
date_created: 2019-08-21T15:00:57Z
date_published: 2019-08-24T00:00:00Z
date_updated: 2023-09-07T13:01:42Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:6825
file:
- access_level: open_access
checksum: 2664420e332a33338568f4f3bfc59287
content_type: application/pdf
creator: kkaefer
date_created: 2019-09-03T08:07:13Z
date_updated: 2020-09-06T22:30:03Z
embargo: 2020-09-05
file_id: '6846'
file_name: Thesis_Kaefer_PDFA.pdf
file_size: 3205202
relation: main_file
request_a_copy: 0
- access_level: closed
checksum: 9a154eab6f07aa590a3d2651dc0d926a
content_type: application/zip
creator: kkaefer
date_created: 2019-09-03T08:07:17Z
date_updated: 2020-09-15T22:30:05Z
embargo_to: open_access
file_id: '6847'
file_name: Thesis_Kaefer.zip
file_size: 2506835
relation: main_file
file_date_updated: 2020-09-15T22:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '89'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '5949'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: The hippocampus and medial prefrontal cortex during flexible behavior
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6828'
abstract:
- lang: eng
text: In this paper we construct a family of exact functors from the category of
Whittaker modules of the simple complex Lie algebra of type to the category of
finite-dimensional modules of the graded affine Hecke algebra of type . Using
results of Backelin [2] and of Arakawa-Suzuki [1], we prove that these functors
map standard modules to standard modules (or zero) and simple modules to simple
modules (or zero). Moreover, we show that each simple module of the graded affine
Hecke algebra appears as the image of a simple Whittaker module. Since the Whittaker
category contains the BGG category as a full subcategory, our results generalize
results of Arakawa-Suzuki [1], which in turn generalize Schur-Weyl duality between
finite-dimensional representations of and representations of the symmetric group
.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adam
full_name: Brown, Adam
id: 70B7FDF6-608D-11E9-9333-8535E6697425
last_name: Brown
citation:
ama: Brown A. Arakawa-Suzuki functors for Whittaker modules. Journal of Algebra.
2019;538:261-289. doi:10.1016/j.jalgebra.2019.07.027
apa: Brown, A. (2019). Arakawa-Suzuki functors for Whittaker modules. Journal
of Algebra. Elsevier. https://doi.org/10.1016/j.jalgebra.2019.07.027
chicago: Brown, Adam. “Arakawa-Suzuki Functors for Whittaker Modules.” Journal
of Algebra. Elsevier, 2019. https://doi.org/10.1016/j.jalgebra.2019.07.027.
ieee: A. Brown, “Arakawa-Suzuki functors for Whittaker modules,” Journal of Algebra,
vol. 538. Elsevier, pp. 261–289, 2019.
ista: Brown A. 2019. Arakawa-Suzuki functors for Whittaker modules. Journal of Algebra.
538, 261–289.
mla: Brown, Adam. “Arakawa-Suzuki Functors for Whittaker Modules.” Journal of
Algebra, vol. 538, Elsevier, 2019, pp. 261–89, doi:10.1016/j.jalgebra.2019.07.027.
short: A. Brown, Journal of Algebra 538 (2019) 261–289.
date_created: 2019-08-22T07:54:13Z
date_published: 2019-11-15T00:00:00Z
date_updated: 2023-08-29T07:11:47Z
day: '15'
department:
- _id: HeEd
doi: 10.1016/j.jalgebra.2019.07.027
external_id:
arxiv:
- '1805.04676'
isi:
- '000487176300011'
intvolume: ' 538'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1805.04676
month: '11'
oa: 1
oa_version: Preprint
page: 261-289
publication: Journal of Algebra
publication_identifier:
issn:
- 0021-8693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Arakawa-Suzuki functors for Whittaker modules
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 538
year: '2019'
...
---
_id: '6830'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Contreras X, Hippenmeyer S. Memo1 tiles the radial glial cell grid. Neuron.
2019;103(5):750-752. doi:10.1016/j.neuron.2019.08.021
apa: Contreras, X., & Hippenmeyer, S. (2019). Memo1 tiles the radial glial cell
grid. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.08.021
chicago: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial
Cell Grid.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.08.021.
ieee: X. Contreras and S. Hippenmeyer, “Memo1 tiles the radial glial cell grid,”
Neuron, vol. 103, no. 5. Elsevier, pp. 750–752, 2019.
ista: Contreras X, Hippenmeyer S. 2019. Memo1 tiles the radial glial cell grid.
Neuron. 103(5), 750–752.
mla: Contreras, Ximena, and Simon Hippenmeyer. “Memo1 Tiles the Radial Glial Cell
Grid.” Neuron, vol. 103, no. 5, Elsevier, 2019, pp. 750–52, doi:10.1016/j.neuron.2019.08.021.
short: X. Contreras, S. Hippenmeyer, Neuron 103 (2019) 750–752.
date_created: 2019-08-25T22:00:50Z
date_published: 2019-09-04T00:00:00Z
date_updated: 2024-03-25T23:30:23Z
day: '04'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2019.08.021
external_id:
isi:
- '000484400200002'
pmid:
- '31487522'
intvolume: ' 103'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2019.08.021
month: '09'
oa: 1
oa_version: Published Version
page: 750-752
pmid: 1
publication: Neuron
publication_identifier:
eissn:
- '10974199'
issn:
- '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '7902'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Memo1 tiles the radial glial cell grid
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 103
year: '2019'
...
---
_id: '6831'
abstract:
- lang: eng
text: "* Understanding the mechanisms causing phenotypic differences between females
and males has long fascinated evolutionary biologists. An extensive literature
exists on animal sexual dimorphism but less information is known about sex differences
in plants, particularly the extent of geographical variation in sexual dimorphism
and its life‐cycle dynamics.\r\n* Here, we investigated patterns of genetically
based sexual dimorphism in vegetative and reproductive traits of a wind‐pollinated
dioecious plant, Rumex hastatulus, across three life‐cycle stages using open‐pollinated
families from 30 populations spanning the geographic range and chromosomal variation
(XY and XY1Y2) of the species.\r\n* The direction and degree of sexual dimorphism
was highly variable among populations and life‐cycle stages. Sex‐specific differences
in reproductive function explained a significant amount of temporal change in
sexual dimorphism. For several traits, geographical variation in sexual dimorphism
was associated with bioclimatic parameters, likely due to the differential responses
of the sexes to climate. We found no systematic differences in sexual dimorphism
between chromosome races.\r\n* Sex‐specific trait differences in dioecious plants
largely result from a balance between sexual and natural selection on resource
allocation. Our results indicate that abiotic factors associated with geographical
context also play a role in modifying sexual dimorphism during the plant life‐cycle."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: David
full_name: Field, David
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Spencer C.H.
full_name: Barrett, Spencer C.H.
last_name: Barrett
citation:
ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Variation in sexual dimorphism
in a wind-pollinated plant: The influence of geographical context and life-cycle
dynamics. New Phytologist. 2019;224(3):1108-1120. doi:10.1111/nph.16050'
apa: 'Puixeu Sala, G., Pickup, M., Field, D., & Barrett, S. C. H. (2019). Variation
in sexual dimorphism in a wind-pollinated plant: The influence of geographical
context and life-cycle dynamics. New Phytologist. Wiley. https://doi.org/10.1111/nph.16050'
chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
“Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical
Context and Life-Cycle Dynamics.” New Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.16050.'
ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Variation in
sexual dimorphism in a wind-pollinated plant: The influence of geographical context
and life-cycle dynamics,” New Phytologist, vol. 224, no. 3. Wiley, pp.
1108–1120, 2019.'
ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Variation in sexual
dimorphism in a wind-pollinated plant: The influence of geographical context and
life-cycle dynamics. New Phytologist. 224(3), 1108–1120.'
mla: 'Puixeu Sala, Gemma, et al. “Variation in Sexual Dimorphism in a Wind-Pollinated
Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” New
Phytologist, vol. 224, no. 3, Wiley, 2019, pp. 1108–20, doi:10.1111/nph.16050.'
short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, New Phytologist 224
(2019) 1108–1120.
date_created: 2019-08-25T22:00:51Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-29T07:17:07Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: BeVi
doi: 10.1111/nph.16050
ec_funded: 1
external_id:
isi:
- '000481376500001'
file:
- access_level: open_access
checksum: 6370e7567d96b7b562e77d8b89653f80
content_type: application/pdf
creator: apreinsp
date_created: 2019-08-27T12:44:54Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6833'
file_name: 2019_NewPhytologist_Puixeu.pdf
file_size: 2314016
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 224'
isi: 1
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1108-1120
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9803'
relation: research_data
status: public
- id: '14058'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Variation in sexual dimorphism in a wind-pollinated plant: The influence of
geographical context and life-cycle dynamics'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 224
year: '2019'
...
---
_id: '6832'
abstract:
- lang: eng
text: Steady-state turnover is a hallmark of epithelial tissues throughout adult
life. Intestinal epithelial turnover is marked by continuous cell migration, which
is assumed to be driven by mitotic pressure from the crypts. However, the balance
of forces in renewal remains ill-defined. Combining biophysical modeling and quantitative
three-dimensional tissue imaging with genetic and physical manipulations, we revealed
the existence of an actin-related protein 2/3 complex–dependent active migratory
force, which explains quantitatively the profiles of cell speed, density, and
tissue tension along the villi. Cells migrate collectively with minimal rearrangements
while displaying dual—apicobasal and front-back—polarity characterized by actin-rich
basal protrusions oriented in the direction of migration. We propose that active
migration is a critical component of gut epithelial turnover.
article_processing_charge: No
author:
- first_name: Denis
full_name: Krndija, Denis
last_name: Krndija
- first_name: Fatima El
full_name: Marjou, Fatima El
last_name: Marjou
- first_name: Boris
full_name: Guirao, Boris
last_name: Guirao
- first_name: Sophie
full_name: Richon, Sophie
last_name: Richon
- first_name: Olivier
full_name: Leroy, Olivier
last_name: Leroy
- first_name: Yohanns
full_name: Bellaiche, Yohanns
last_name: Bellaiche
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Danijela Matic
full_name: Vignjevic, Danijela Matic
last_name: Vignjevic
citation:
ama: Krndija D, Marjou FE, Guirao B, et al. Active cell migration is critical for
steady-state epithelial turnover in the gut. Science. 2019;365(6454):705-710.
doi:10.1126/science.aau3429
apa: Krndija, D., Marjou, F. E., Guirao, B., Richon, S., Leroy, O., Bellaiche, Y.,
… Vignjevic, D. M. (2019). Active cell migration is critical for steady-state
epithelial turnover in the gut. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.aau3429
chicago: Krndija, Denis, Fatima El Marjou, Boris Guirao, Sophie Richon, Olivier
Leroy, Yohanns Bellaiche, Edouard B Hannezo, and Danijela Matic Vignjevic. “Active
Cell Migration Is Critical for Steady-State Epithelial Turnover in the Gut.” Science.
American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aau3429.
ieee: D. Krndija et al., “Active cell migration is critical for steady-state
epithelial turnover in the gut,” Science, vol. 365, no. 6454. American
Association for the Advancement of Science, pp. 705–710, 2019.
ista: Krndija D, Marjou FE, Guirao B, Richon S, Leroy O, Bellaiche Y, Hannezo EB,
Vignjevic DM. 2019. Active cell migration is critical for steady-state epithelial
turnover in the gut. Science. 365(6454), 705–710.
mla: Krndija, Denis, et al. “Active Cell Migration Is Critical for Steady-State
Epithelial Turnover in the Gut.” Science, vol. 365, no. 6454, American
Association for the Advancement of Science, 2019, pp. 705–10, doi:10.1126/science.aau3429.
short: D. Krndija, F.E. Marjou, B. Guirao, S. Richon, O. Leroy, Y. Bellaiche, E.B.
Hannezo, D.M. Vignjevic, Science 365 (2019) 705–710.
date_created: 2019-08-25T22:00:51Z
date_published: 2019-08-16T00:00:00Z
date_updated: 2023-08-29T07:16:40Z
day: '16'
department:
- _id: EdHa
doi: 10.1126/science.aau3429
external_id:
isi:
- '000481688700050'
pmid:
- '31416964'
intvolume: ' 365'
isi: 1
issue: '6454'
language:
- iso: eng
month: '08'
oa_version: None
page: 705-710
pmid: 1
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Active cell migration is critical for steady-state epithelial turnover in the
gut
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 365
year: '2019'
...
---
_id: '6835'
abstract:
- lang: eng
text: We derive the Hasse principle and weak approximation for fibrations of certain
varieties in the spirit of work by Colliot-Thélène–Sansuc and Harpaz–Skorobogatov–Wittenberg.
Our varieties are defined through polynomials in many variables and part of our
work is devoted to establishing Schinzel's hypothesis for polynomials of this
kind. This last part is achieved by using arguments behind Birch's well-known
result regarding the Hasse principle for complete intersections with the notable
difference that we prove our result in 50% fewer variables than in the classical
Birch setting. We also study the problem of square-free values of an integer polynomial
with 66.6% fewer variables than in the Birch setting.
article_number: '102794'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Kevin N
full_name: Destagnol, Kevin N
id: 44DDECBC-F248-11E8-B48F-1D18A9856A87
last_name: Destagnol
- first_name: Efthymios
full_name: Sofos, Efthymios
last_name: Sofos
citation:
ama: Destagnol KN, Sofos E. Rational points and prime values of polynomials in moderately
many variables. Bulletin des Sciences Mathematiques. 2019;156(11). doi:10.1016/j.bulsci.2019.102794
apa: Destagnol, K. N., & Sofos, E. (2019). Rational points and prime values
of polynomials in moderately many variables. Bulletin Des Sciences Mathematiques.
Elsevier. https://doi.org/10.1016/j.bulsci.2019.102794
chicago: Destagnol, Kevin N, and Efthymios Sofos. “Rational Points and Prime Values
of Polynomials in Moderately Many Variables.” Bulletin Des Sciences Mathematiques.
Elsevier, 2019. https://doi.org/10.1016/j.bulsci.2019.102794.
ieee: K. N. Destagnol and E. Sofos, “Rational points and prime values of polynomials
in moderately many variables,” Bulletin des Sciences Mathematiques, vol.
156, no. 11. Elsevier, 2019.
ista: Destagnol KN, Sofos E. 2019. Rational points and prime values of polynomials
in moderately many variables. Bulletin des Sciences Mathematiques. 156(11), 102794.
mla: Destagnol, Kevin N., and Efthymios Sofos. “Rational Points and Prime Values
of Polynomials in Moderately Many Variables.” Bulletin Des Sciences Mathematiques,
vol. 156, no. 11, 102794, Elsevier, 2019, doi:10.1016/j.bulsci.2019.102794.
short: K.N. Destagnol, E. Sofos, Bulletin Des Sciences Mathematiques 156 (2019).
date_created: 2019-09-01T22:00:55Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-29T07:18:02Z
day: '01'
department:
- _id: TiBr
doi: 10.1016/j.bulsci.2019.102794
external_id:
arxiv:
- '1801.03082'
isi:
- '000496342100002'
intvolume: ' 156'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1801.03082
month: '11'
oa: 1
oa_version: Preprint
publication: Bulletin des Sciences Mathematiques
publication_identifier:
issn:
- 0007-4497
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rational points and prime values of polynomials in moderately many variables
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 156
year: '2019'
...
---
_id: '6836'
abstract:
- lang: eng
text: Direct reciprocity is a powerful mechanism for the evolution of cooperation
on the basis of repeated interactions1,2,3,4. It requires that interacting individuals
are sufficiently equal, such that everyone faces similar consequences when they
cooperate or defect. Yet inequality is ubiquitous among humans5,6 and is generally
considered to undermine cooperation and welfare7,8,9,10. Most previous models
of reciprocity do not include inequality11,12,13,14,15. These models assume that
individuals are the same in all relevant aspects. Here we introduce a general
framework to study direct reciprocity among unequal individuals. Our model allows
for multiple sources of inequality. Subjects can differ in their endowments, their
productivities and in how much they benefit from public goods. We find that extreme
inequality prevents cooperation. But if subjects differ in productivity, some
endowment inequality can be necessary for cooperation to prevail. Our mathematical
predictions are supported by a behavioural experiment in which we vary the endowments
and productivities of the subjects. We observe that overall welfare is maximized
when the two sources of heterogeneity are aligned, such that more productive individuals
receive higher endowments. By contrast, when endowments and productivities are
misaligned, cooperation quickly breaks down. Our findings have implications for
policy-makers concerned with equity, efficiency and the provisioning of public
goods.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Oliver P.
full_name: Hauser, Oliver P.
last_name: Hauser
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Hauser OP, Hilbe C, Chatterjee K, Nowak MA. Social dilemmas among unequals.
Nature. 2019;572(7770):524-527. doi:10.1038/s41586-019-1488-5
apa: Hauser, O. P., Hilbe, C., Chatterjee, K., & Nowak, M. A. (2019). Social
dilemmas among unequals. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1488-5
chicago: Hauser, Oliver P., Christian Hilbe, Krishnendu Chatterjee, and Martin A.
Nowak. “Social Dilemmas among Unequals.” Nature. Springer Nature, 2019.
https://doi.org/10.1038/s41586-019-1488-5.
ieee: O. P. Hauser, C. Hilbe, K. Chatterjee, and M. A. Nowak, “Social dilemmas among
unequals,” Nature, vol. 572, no. 7770. Springer Nature, pp. 524–527, 2019.
ista: Hauser OP, Hilbe C, Chatterjee K, Nowak MA. 2019. Social dilemmas among unequals.
Nature. 572(7770), 524–527.
mla: Hauser, Oliver P., et al. “Social Dilemmas among Unequals.” Nature,
vol. 572, no. 7770, Springer Nature, 2019, pp. 524–27, doi:10.1038/s41586-019-1488-5.
short: O.P. Hauser, C. Hilbe, K. Chatterjee, M.A. Nowak, Nature 572 (2019) 524–527.
date_created: 2019-09-01T22:00:56Z
date_published: 2019-08-22T00:00:00Z
date_updated: 2023-08-29T07:42:54Z
day: '22'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41586-019-1488-5
ec_funded: 1
external_id:
isi:
- '000482219600045'
file:
- access_level: open_access
checksum: a6e0e3168bf62de624e7772cdfaeb26f
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T10:00:32Z
date_updated: 2020-07-14T12:47:42Z
file_id: '7828'
file_name: 2019_Nature_Hauser.pdf
file_size: 18577756
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 572'
isi: 1
issue: '7770'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 524-527
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/too-much-inequality-impedes-support-for-public-goods-according-to-research-published-in-nature/
scopus_import: '1'
status: public
title: Social dilemmas among unequals
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 572
year: '2019'
...
---
_id: '6837'
abstract:
- lang: eng
text: Migrasomes are a recently discovered type of extracellular vesicles that are
characteristically generated along retraction fibers in migrating cells. Two studies
now show how migrasomes are formed and how they function in the physiologically
relevant context of the developing zebrafish embryo.
article_processing_charge: No
author:
- first_name: Ste
full_name: Tavano, Ste
id: 2F162F0C-F248-11E8-B48F-1D18A9856A87
last_name: Tavano
orcid: 0000-0001-9970-7804
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Tavano S, Heisenberg C-PJ. Migrasomes take center stage. Nature Cell Biology.
2019;21(8):918-920. doi:10.1038/s41556-019-0369-3
apa: Tavano, S., & Heisenberg, C.-P. J. (2019). Migrasomes take center stage.
Nature Cell Biology. Springer Nature. https://doi.org/10.1038/s41556-019-0369-3
chicago: Tavano, Ste, and Carl-Philipp J Heisenberg. “Migrasomes Take Center Stage.”
Nature Cell Biology. Springer Nature, 2019. https://doi.org/10.1038/s41556-019-0369-3.
ieee: S. Tavano and C.-P. J. Heisenberg, “Migrasomes take center stage,” Nature
Cell Biology, vol. 21, no. 8. Springer Nature, pp. 918–920, 2019.
ista: Tavano S, Heisenberg C-PJ. 2019. Migrasomes take center stage. Nature Cell
Biology. 21(8), 918–920.
mla: Tavano, Ste, and Carl-Philipp J. Heisenberg. “Migrasomes Take Center Stage.”
Nature Cell Biology, vol. 21, no. 8, Springer Nature, 2019, pp. 918–20,
doi:10.1038/s41556-019-0369-3.
short: S. Tavano, C.-P.J. Heisenberg, Nature Cell Biology 21 (2019) 918–920.
date_created: 2019-09-01T22:00:57Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-08-29T07:42:20Z
day: '01'
department:
- _id: CaHe
doi: 10.1038/s41556-019-0369-3
external_id:
isi:
- '000478029000003'
pmid:
- '31371826'
intvolume: ' 21'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 918-920
pmid: 1
publication: Nature Cell Biology
publication_identifier:
eissn:
- 1476-4679
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Migrasomes take center stage
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 21
year: '2019'
...
---
_id: '6840'
abstract:
- lang: eng
text: "We discuss thermodynamic properties of harmonically trapped\r\nimperfect
quantum gases. The spatial inhomogeneity of these systems imposes\r\na redefinition
of the mean-field interparticle potential energy as compared\r\nto the homogeneous
case. In our approach, it takes the form a\r\n2N2 ωd, where\r\nN is the number
of particles, ω—the harmonic trap frequency, d—system’s\r\ndimensionality, and
a is a parameter characterizing the interparticle interaction.\r\nWe provide arguments
that this model corresponds to the limiting case of\r\na long-ranged interparticle
potential of vanishingly small amplitude. This\r\nconclusion is drawn from a computation
similar to the well-known Kac scaling\r\nprocedure, which is presented here in
a form adapted to the case of an isotropic\r\nharmonic trap. We show that within
the model, the imperfect gas of trapped\r\nrepulsive bosons undergoes the Bose–Einstein
condensation provided d > 1.\r\nThe main result of our analysis is that in d =
1 the gas of attractive imperfect\r\nfermions with a = −aF < 0 is thermodynamically
equivalent to the gas of\r\nrepulsive bosons with a = aB > 0 provided the parameters
aF and aB fulfill\r\nthe relation aB + aF = \x1F. This result supplements similar
recent conclusion\r\nabout thermodynamic equivalence of two-dimensional (2D) uniform
imperfect\r\nrepulsive Bose and attractive Fermi gases."
article_number: '063101'
article_processing_charge: No
arxiv: 1
author:
- first_name: Krzysztof
full_name: Mysliwy, Krzysztof
id: 316457FC-F248-11E8-B48F-1D18A9856A87
last_name: Mysliwy
- first_name: Marek
full_name: Napiórkowski, Marek
last_name: Napiórkowski
citation:
ama: 'Mysliwy K, Napiórkowski M. Thermodynamics of inhomogeneous imperfect quantum
gases in harmonic traps. Journal of Statistical Mechanics: Theory and Experiment.
2019;2019(6). doi:10.1088/1742-5468/ab190d'
apa: 'Mysliwy, K., & Napiórkowski, M. (2019). Thermodynamics of inhomogeneous
imperfect quantum gases in harmonic traps. Journal of Statistical Mechanics:
Theory and Experiment. IOP Publishing. https://doi.org/10.1088/1742-5468/ab190d'
chicago: 'Mysliwy, Krzysztof, and Marek Napiórkowski. “Thermodynamics of Inhomogeneous
Imperfect Quantum Gases in Harmonic Traps.” Journal of Statistical Mechanics:
Theory and Experiment. IOP Publishing, 2019. https://doi.org/10.1088/1742-5468/ab190d.'
ieee: 'K. Mysliwy and M. Napiórkowski, “Thermodynamics of inhomogeneous imperfect
quantum gases in harmonic traps,” Journal of Statistical Mechanics: Theory
and Experiment, vol. 2019, no. 6. IOP Publishing, 2019.'
ista: 'Mysliwy K, Napiórkowski M. 2019. Thermodynamics of inhomogeneous imperfect
quantum gases in harmonic traps. Journal of Statistical Mechanics: Theory and
Experiment. 2019(6), 063101.'
mla: 'Mysliwy, Krzysztof, and Marek Napiórkowski. “Thermodynamics of Inhomogeneous
Imperfect Quantum Gases in Harmonic Traps.” Journal of Statistical Mechanics:
Theory and Experiment, vol. 2019, no. 6, 063101, IOP Publishing, 2019, doi:10.1088/1742-5468/ab190d.'
short: 'K. Mysliwy, M. Napiórkowski, Journal of Statistical Mechanics: Theory and
Experiment 2019 (2019).'
date_created: 2019-09-01T22:00:59Z
date_published: 2019-06-13T00:00:00Z
date_updated: 2023-08-29T07:19:13Z
day: '13'
department:
- _id: RoSe
doi: 10.1088/1742-5468/ab190d
ec_funded: 1
external_id:
arxiv:
- '1810.02209'
isi:
- '000471650100001'
intvolume: ' 2019'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1810.02209
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: 'Journal of Statistical Mechanics: Theory and Experiment'
publication_identifier:
eissn:
- 1742-5468
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamics of inhomogeneous imperfect quantum gases in harmonic traps
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 2019
year: '2019'
...
---
_id: '6843'
abstract:
- lang: eng
text: The aim of this short paper is to offer a complete characterization of all
(not necessarily surjective) isometric embeddings of the Wasserstein space Wp(X),
where S is a countable discrete metric space and 0Journal of Mathematical Analysis and Applications.
2019;480(2). doi:10.1016/j.jmaa.2019.123435
apa: Gehér, G. P., Titkos, T., & Virosztek, D. (2019). On isometric embeddings
of Wasserstein spaces – the discrete case. Journal of Mathematical Analysis
and Applications. Elsevier. https://doi.org/10.1016/j.jmaa.2019.123435
chicago: Gehér, György Pál, Tamás Titkos, and Daniel Virosztek. “On Isometric Embeddings
of Wasserstein Spaces – the Discrete Case.” Journal of Mathematical Analysis
and Applications. Elsevier, 2019. https://doi.org/10.1016/j.jmaa.2019.123435.
ieee: G. P. Gehér, T. Titkos, and D. Virosztek, “On isometric embeddings of Wasserstein
spaces – the discrete case,” Journal of Mathematical Analysis and Applications,
vol. 480, no. 2. Elsevier, 2019.
ista: Gehér GP, Titkos T, Virosztek D. 2019. On isometric embeddings of Wasserstein
spaces – the discrete case. Journal of Mathematical Analysis and Applications.
480(2), 123435.
mla: Gehér, György Pál, et al. “On Isometric Embeddings of Wasserstein Spaces –
the Discrete Case.” Journal of Mathematical Analysis and Applications,
vol. 480, no. 2, 123435, Elsevier, 2019, doi:10.1016/j.jmaa.2019.123435.
short: G.P. Gehér, T. Titkos, D. Virosztek, Journal of Mathematical Analysis and
Applications 480 (2019).
date_created: 2019-09-01T22:01:01Z
date_published: 2019-12-15T00:00:00Z
date_updated: 2023-08-29T07:18:50Z
day: '15'
department:
- _id: LaEr
doi: 10.1016/j.jmaa.2019.123435
ec_funded: 1
external_id:
arxiv:
- '1809.01101'
isi:
- '000486563900031'
intvolume: ' 480'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1809.01101
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Journal of Mathematical Analysis and Applications
publication_identifier:
eissn:
- '10960813'
issn:
- 0022247X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: On isometric embeddings of Wasserstein spaces – the discrete case
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 480
year: '2019'
...
---
_id: '6844'
abstract:
- lang: eng
text: Studying the progression of the proliferative and differentiative patterns
of neural stem cells at the individual cell level is crucial to the understanding
of cortex development and how the disruption of such patterns can lead to malformations
and neurodevelopmental diseases. However, our understanding of the precise lineage
progression programme at single-cell resolution is still incomplete due to the
technical variations in lineage- tracing approaches. One of the key challenges
involves developing a robust theoretical framework in which we can integrate experimental
observations and introduce correction factors to obtain a reliable and representative
description of the temporal modulation of proliferation and differentiation. In
order to obtain more conclusive insights, we carry out virtual clonal analysis
using mathematical modelling and compare our results against experimental data.
Using a dataset obtained with Mosaic Analysis with Double Markers, we illustrate
how the theoretical description can be exploited to interpret and reconcile the
disparity between virtual and experimental results.
article_processing_charge: No
article_type: original
author:
- first_name: Noemi
full_name: Picco, Noemi
last_name: Picco
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Julio
full_name: Rodarte, Julio
id: 3C70A038-F248-11E8-B48F-1D18A9856A87
last_name: Rodarte
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Zoltán
full_name: Molnár, Zoltán
last_name: Molnár
- first_name: Philip K.
full_name: Maini, Philip K.
last_name: Maini
- first_name: Thomas E.
full_name: Woolley, Thomas E.
last_name: Woolley
citation:
ama: Picco N, Hippenmeyer S, Rodarte J, et al. A mathematical insight into cell
labelling experiments for clonal analysis. Journal of Anatomy. 2019;235(3):686-696.
doi:10.1111/joa.13001
apa: Picco, N., Hippenmeyer, S., Rodarte, J., Streicher, C., Molnár, Z., Maini,
P. K., & Woolley, T. E. (2019). A mathematical insight into cell labelling
experiments for clonal analysis. Journal of Anatomy. Wiley. https://doi.org/10.1111/joa.13001
chicago: Picco, Noemi, Simon Hippenmeyer, Julio Rodarte, Carmen Streicher, Zoltán
Molnár, Philip K. Maini, and Thomas E. Woolley. “A Mathematical Insight into Cell
Labelling Experiments for Clonal Analysis.” Journal of Anatomy. Wiley,
2019. https://doi.org/10.1111/joa.13001.
ieee: N. Picco et al., “A mathematical insight into cell labelling experiments
for clonal analysis,” Journal of Anatomy, vol. 235, no. 3. Wiley, pp. 686–696,
2019.
ista: Picco N, Hippenmeyer S, Rodarte J, Streicher C, Molnár Z, Maini PK, Woolley
TE. 2019. A mathematical insight into cell labelling experiments for clonal analysis.
Journal of Anatomy. 235(3), 686–696.
mla: Picco, Noemi, et al. “A Mathematical Insight into Cell Labelling Experiments
for Clonal Analysis.” Journal of Anatomy, vol. 235, no. 3, Wiley, 2019,
pp. 686–96, doi:10.1111/joa.13001.
short: N. Picco, S. Hippenmeyer, J. Rodarte, C. Streicher, Z. Molnár, P.K. Maini,
T.E. Woolley, Journal of Anatomy 235 (2019) 686–696.
date_created: 2019-09-02T11:57:28Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2023-08-29T07:19:39Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1111/joa.13001
ec_funded: 1
external_id:
isi:
- '000482426800017'
file:
- access_level: open_access
checksum: 160f960844b204057f20896e0e1f8ee7
content_type: application/pdf
creator: dernst
date_created: 2019-09-02T12:05:18Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6845'
file_name: 2019_JournalAnatomy_Picco.pdf
file_size: 1192994
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 235'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '09'
oa: 1
oa_version: Published Version
page: 686-696
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Journal of Anatomy
publication_identifier:
eissn:
- 1469-7580
issn:
- 0021-8782
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A mathematical insight into cell labelling experiments for clonal analysis
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 235
year: '2019'
...
---
_id: '6848'
abstract:
- lang: eng
text: Proton-translocating transhydrogenase (also known as nicotinamide nucleotide
transhydrogenase (NNT)) is found in the plasma membranes of bacteria and the inner
mitochondrial membranes of eukaryotes. NNT catalyses the transfer of a hydride
between NADH and NADP+, coupled to the translocation of one proton across the
membrane. Its main physiological function is the generation of NADPH, which is
a substrate in anabolic reactions and a regulator of oxidative status; however,
NNT may also fine-tune the Krebs cycle1,2. NNT deficiency causes familial glucocorticoid
deficiency in humans and metabolic abnormalities in mice, similar to those observed
in type II diabetes3,4. The catalytic mechanism of NNT has been proposed to involve
a rotation of around 180° of the entire NADP(H)-binding domain that alternately
participates in hydride transfer and proton-channel gating. However, owing to
the lack of high-resolution structures of intact NNT, the details of this process
remain unclear5,6. Here we present the cryo-electron microscopy structure of intact
mammalian NNT in different conformational states. We show how the NADP(H)-binding
domain opens the proton channel to the opposite sides of the membrane, and we
provide structures of these two states. We also describe the catalytically important
interfaces and linkers between the membrane and the soluble domains and their
roles in nucleotide exchange. These structures enable us to propose a revised
mechanism for a coupling process in NNT that is consistent with a large body of
previous biochemical work. Our results are relevant to the development of currently
unavailable NNT inhibitors, which may have therapeutic potential in ischaemia
reperfusion injury, metabolic syndrome and some cancers7,8,9.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: " We thank R. Thompson, G. Effantin and V.-V. Hodirnau for their
assistance with collecting NADP+, NADPH and apo datasets, respectively. Data processing
was performed at the IST high-performance computing cluster.\r\nThis project has
received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie Grant Agreement no. 665385."
article_processing_charge: No
article_type: letter_note
author:
- first_name: Domen
full_name: Kampjut, Domen
id: 37233050-F248-11E8-B48F-1D18A9856A87
last_name: Kampjut
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Kampjut D, Sazanov LA. Structure and mechanism of mitochondrial proton-translocating
transhydrogenase. Nature. 2019;573(7773):291–295. doi:10.1038/s41586-019-1519-2
apa: Kampjut, D., & Sazanov, L. A. (2019). Structure and mechanism of mitochondrial
proton-translocating transhydrogenase. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1519-2
chicago: Kampjut, Domen, and Leonid A Sazanov. “Structure and Mechanism of Mitochondrial
Proton-Translocating Transhydrogenase.” Nature. Springer Nature, 2019.
https://doi.org/10.1038/s41586-019-1519-2.
ieee: D. Kampjut and L. A. Sazanov, “Structure and mechanism of mitochondrial proton-translocating
transhydrogenase,” Nature, vol. 573, no. 7773. Springer Nature, pp. 291–295,
2019.
ista: Kampjut D, Sazanov LA. 2019. Structure and mechanism of mitochondrial proton-translocating
transhydrogenase. Nature. 573(7773), 291–295.
mla: Kampjut, Domen, and Leonid A. Sazanov. “Structure and Mechanism of Mitochondrial
Proton-Translocating Transhydrogenase.” Nature, vol. 573, no. 7773, Springer
Nature, 2019, pp. 291–295, doi:10.1038/s41586-019-1519-2.
short: D. Kampjut, L.A. Sazanov, Nature 573 (2019) 291–295.
date_created: 2019-09-04T06:21:41Z
date_published: 2019-09-12T00:00:00Z
date_updated: 2024-03-25T23:30:08Z
day: '12'
ddc:
- '572'
department:
- _id: LeSa
doi: 10.1038/s41586-019-1519-2
ec_funded: 1
external_id:
isi:
- '000485415400061'
pmid:
- '31462775'
file:
- access_level: open_access
checksum: 52728cda5210a3e9b74cc204e8aed3d5
content_type: application/pdf
creator: lsazanov
date_created: 2020-11-26T16:33:44Z
date_updated: 2020-11-26T16:33:44Z
file_id: '8821'
file_name: Manuscript_final_acc_withFigs_SI_opt_red.pdf
file_size: 3066206
relation: main_file
success: 1
file_date_updated: 2020-11-26T16:33:44Z
has_accepted_license: '1'
intvolume: ' 573'
isi: 1
issue: '7773'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 291–295
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/high-end-microscopy-reveals-structure-and-function-of-crucial-metabolic-enzyme/
record:
- id: '8340'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Structure and mechanism of mitochondrial proton-translocating transhydrogenase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 573
year: '2019'
...
---
_id: '6849'
abstract:
- lang: eng
text: 'Brain function is mediated by complex dynamical interactions between excitatory
and inhibitory cell types. The Cholecystokinin-expressing inhibitory cells (CCK-interneurons)
are one of the least studied types, despite being suspected to play important
roles in cognitive processes. We studied the network effects of optogenetic silencing
of CCK-interneurons in the CA1 hippocampal area during exploration and sleep states.
The cell firing pattern in response to light pulses allowed us to classify the
recorded neurons in 5 classes, including disinhibited and non-responsive pyramidal
cell and interneurons, and the inhibited interneurons corresponding to the CCK
group. The light application, which inhibited the activity of CCK interneurons
triggered wider changes in the firing dynamics of cells. We observed rate changes
(i.e. remapping) of pyramidal cells during the exploration session in which the
light was applied relative to the previous control session that was not restricted
neither in time nor space to the light delivery. Also, the disinhibited pyramidal
cells had higher increase in bursting than in single spike firing rate as a result
of CCK silencing. In addition, the firing activity patterns during exploratory
periods were more weakly reactivated in sleep for those periods in which CCK-interneuron
were silenced than in the unaffected periods. Furthermore, light pulses during
sleep disrupted the reactivation of recent waking patterns. Hence, silencing CCK
neurons during exploration suppressed the reactivation of waking firing patterns
in sleep and CCK interneuron activity was also required during sleep for the normal
reactivation of waking patterns. These findings demonstrate the involvement of
CCK cells in reactivation-related memory consolidation. An important part of our
analysis was to test the relationship of the identified CCKinterneurons to brain
oscillations. Our findings showed that these cells exhibited different oscillatory
behaviour during anaesthesia and natural waking and sleep conditions. We showed
that: 1) Contrary to the past studies performed under anaesthesia, the identified
CCKinterneurons fired on the descending portion of the theta phase in waking exploration.
2) CCKinterneuron preferred phases around the trough of gamma oscillations. 3)
Contrary to anaesthesia conditions, the average firing rate of the CCK-interneurons
increased around the peak activity of the sharp-wave ripple (SWR) events in natural
sleep, which is congruent with new reports about their functional connectivity.
We also found that light driven CCK-interneuron silencing altered the dynamics
on the CA1 network oscillatory activity: 1) Pyramidal cells negatively shifted
their preferred theta phases when the light was applied, while interneurons responses
were less consistent. 2) As a population, pyramidal cells negatively shifted their
preferred activity during gamma oscillations, albeit we did not find gamma modulation
differences related to the light application when pyramidal cells were subdivided
into the disinhibited and unaffected groups. 3) During the peak of SWR events,
all but the CCK-interneurons had a reduction in their relative firing rate change
during the light application as compared to the change observed at SWR initiation.
Finally, regarding to the place field activity of the recorded pyramidal neurons,
we showed that the disinhibited pyramidal cells had reduced place field similarity,
coherence and spatial information, but only during the light application. The
mechanisms behind such observed behaviours might involve eCB signalling and plastic
changes in CCK-interneuron synapses. In conclusion, the observed changes related
to the light-mediated silencing of CCKinterneurons have unravelled characteristics
of this interneuron subpopulation that might change the understanding not only
of their particular network interactions, but also of the current theories about
the emergence of certain cognitive processes such as place coding needed for navigation
or hippocampus-dependent memory consolidation. '
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
citation:
ama: Rangel Guerrero DK. The role of CCK-interneurons in regulating hippocampal
network dynamics. 2019. doi:10.15479/AT:ISTA:6849
apa: Rangel Guerrero, D. K. (2019). The role of CCK-interneurons in regulating
hippocampal network dynamics. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:6849
chicago: Rangel Guerrero, Dámaris K. “The Role of CCK-Interneurons in Regulating
Hippocampal Network Dynamics.” Institute of Science and Technology Austria, 2019.
https://doi.org/10.15479/AT:ISTA:6849.
ieee: D. K. Rangel Guerrero, “The role of CCK-interneurons in regulating hippocampal
network dynamics,” Institute of Science and Technology Austria, 2019.
ista: Rangel Guerrero DK. 2019. The role of CCK-interneurons in regulating hippocampal
network dynamics. Institute of Science and Technology Austria.
mla: Rangel Guerrero, Dámaris K. The Role of CCK-Interneurons in Regulating Hippocampal
Network Dynamics. Institute of Science and Technology Austria, 2019, doi:10.15479/AT:ISTA:6849.
short: D.K. Rangel Guerrero, The Role of CCK-Interneurons in Regulating Hippocampal
Network Dynamics, Institute of Science and Technology Austria, 2019.
date_created: 2019-09-06T06:54:16Z
date_published: 2019-09-09T00:00:00Z
date_updated: 2023-09-19T10:01:12Z
day: '09'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:6849
file:
- access_level: closed
checksum: 244dc4f74dbfc94f414156092298831f
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: drangel
date_created: 2019-09-09T13:09:45Z
date_updated: 2021-02-10T23:30:09Z
embargo_to: open_access
file_id: '6865'
file_name: Thesis_Damaris_Rangel_source.docx
file_size: 18253100
relation: source_file
- access_level: open_access
checksum: 59c73be40eeaa1c4db24067270151555
content_type: application/pdf
creator: drangel
date_created: 2019-09-09T13:09:52Z
date_updated: 2020-09-11T22:30:04Z
embargo: 2020-09-10
file_id: '6866'
file_name: Thesis_Damaris_Rangel_pdfa.pdf
file_size: 2160109
relation: main_file
request_a_copy: 0
file_date_updated: 2021-02-10T23:30:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '97'
publication_identifier:
isbn:
- '9783990780039'
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '5914'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: The role of CCK-interneurons in regulating hippocampal network dynamics
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6855'
abstract:
- lang: eng
text: Many traits of interest are highly heritable and genetically complex, meaning
that much of the variation they exhibit arises from differences at numerous loci
in the genome. Complex traits and their evolution have been studied for more than
a century, but only in the last decade have genome-wide association studies (GWASs)
in humans begun to reveal their genetic basis. Here, we bring these threads of
research together to ask how findings from GWASs can further our understanding
of the processes that give rise to heritable variation in complex traits and of
the genetic basis of complex trait evolution in response to changing selection
pressures (i.e., of polygenic adaptation). Conversely, we ask how evolutionary
thinking helps us to interpret findings from GWASs and informs related efforts
of practical importance.
article_processing_charge: No
author:
- first_name: Guy
full_name: Sella, Guy
last_name: Sella
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Sella G, Barton NH. Thinking about the evolution of complex traits in the era
of genome-wide association studies. Annual Review of Genomics and Human Genetics.
2019;20:461-493. doi:10.1146/annurev-genom-083115-022316
apa: Sella, G., & Barton, N. H. (2019). Thinking about the evolution of complex
traits in the era of genome-wide association studies. Annual Review of Genomics
and Human Genetics. Annual Reviews. https://doi.org/10.1146/annurev-genom-083115-022316
chicago: Sella, Guy, and Nicholas H Barton. “Thinking about the Evolution of Complex
Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics
and Human Genetics. Annual Reviews, 2019. https://doi.org/10.1146/annurev-genom-083115-022316.
ieee: G. Sella and N. H. Barton, “Thinking about the evolution of complex traits
in the era of genome-wide association studies,” Annual Review of Genomics and
Human Genetics, vol. 20. Annual Reviews, pp. 461–493, 2019.
ista: Sella G, Barton NH. 2019. Thinking about the evolution of complex traits in
the era of genome-wide association studies. Annual Review of Genomics and Human
Genetics. 20, 461–493.
mla: Sella, Guy, and Nicholas H. Barton. “Thinking about the Evolution of Complex
Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics
and Human Genetics, vol. 20, Annual Reviews, 2019, pp. 461–93, doi:10.1146/annurev-genom-083115-022316.
short: G. Sella, N.H. Barton, Annual Review of Genomics and Human Genetics 20 (2019)
461–493.
date_created: 2019-09-07T14:28:29Z
date_published: 2019-07-05T00:00:00Z
date_updated: 2023-08-29T07:49:38Z
day: '05'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1146/annurev-genom-083115-022316
external_id:
isi:
- '000485148400020'
pmid:
- '31283361'
file:
- access_level: open_access
checksum: 23d3978cf4739a89ce2c3e779f9305ca
content_type: application/pdf
creator: dernst
date_created: 2019-09-09T07:22:12Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6862'
file_name: 2019_AnnualReview_Sella.pdf
file_size: 411491
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 461-493
pmid: 1
publication: Annual Review of Genomics and Human Genetics
publication_identifier:
eissn:
- 1545-293X
issn:
- 1527-8204
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thinking about the evolution of complex traits in the era of genome-wide association
studies
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2019'
...
---
_id: '6856'
abstract:
- lang: eng
text: 'Plant mating systems play a key role in structuring genetic variation both
within and between species. In hybrid zones, the outcomes and dynamics of hybridization
are usually interpreted as the balance between gene flow and selection against
hybrids. Yet, mating systems can introduce selective forces that alter these expectations;
with diverse outcomes for the level and direction of gene flow depending on variation
in outcrossing and whether the mating systems of the species pair are the same
or divergent. We present a survey of hybridization in 133 species pairs from 41
plant families and examine how patterns of hybridization vary with mating system.
We examine if hybrid zone mode, level of gene flow, asymmetries in gene flow and
the frequency of reproductive isolating barriers vary in relation to mating system/s
of the species pair. We combine these results with a simulation model and examples
from the literature to address two general themes: (i) the two‐way interaction
between introgression and the evolution of reproductive systems, and (ii) how
mating system can facilitate or restrict interspecific gene flow. We conclude
that examining mating system with hybridization provides unique opportunities
to understand divergence and the processes underlying reproductive isolation.'
article_processing_charge: No
article_type: original
author:
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Yaniv
full_name: Brandvain, Yaniv
last_name: Brandvain
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Sarah
full_name: Yakimowski, Sarah
last_name: Yakimowski
- first_name: Tanmay
full_name: Dixit, Tanmay
last_name: Dixit
- first_name: Christian
full_name: Lexer, Christian
last_name: Lexer
- first_name: Eva
full_name: Cereghetti, Eva
id: 71AA91B4-05ED-11EA-8BEB-F5833E63BD63
last_name: Cereghetti
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
citation:
ama: 'Pickup M, Barton NH, Brandvain Y, et al. Mating system variation in hybrid
zones: Facilitation, barriers and asymmetries to gene flow. New Phytologist.
2019;224(3):1035-1047. doi:10.1111/nph.16180'
apa: 'Pickup, M., Barton, N. H., Brandvain, Y., Fraisse, C., Yakimowski, S., Dixit,
T., … Field, D. (2019). Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow. New Phytologist. Wiley. https://doi.org/10.1111/nph.16180'
chicago: 'Pickup, Melinda, Nicholas H Barton, Yaniv Brandvain, Christelle Fraisse,
Sarah Yakimowski, Tanmay Dixit, Christian Lexer, Eva Cereghetti, and David Field.
“Mating System Variation in Hybrid Zones: Facilitation, Barriers and Asymmetries
to Gene Flow.” New Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.16180.'
ieee: 'M. Pickup et al., “Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow,” New Phytologist, vol. 224, no.
3. Wiley, pp. 1035–1047, 2019.'
ista: 'Pickup M, Barton NH, Brandvain Y, Fraisse C, Yakimowski S, Dixit T, Lexer
C, Cereghetti E, Field D. 2019. Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow. New Phytologist. 224(3), 1035–1047.'
mla: 'Pickup, Melinda, et al. “Mating System Variation in Hybrid Zones: Facilitation,
Barriers and Asymmetries to Gene Flow.” New Phytologist, vol. 224, no.
3, Wiley, 2019, pp. 1035–47, doi:10.1111/nph.16180.'
short: M. Pickup, N.H. Barton, Y. Brandvain, C. Fraisse, S. Yakimowski, T. Dixit,
C. Lexer, E. Cereghetti, D. Field, New Phytologist 224 (2019) 1035–1047.
date_created: 2019-09-07T14:35:40Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-10-18T08:47:08Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/nph.16180
ec_funded: 1
external_id:
pmid:
- '31505037'
file:
- access_level: open_access
checksum: 21e4c95599bbcaf7c483b89954658672
content_type: application/pdf
creator: dernst
date_created: 2019-11-13T08:15:05Z
date_updated: 2020-07-14T12:47:42Z
file_id: '7011'
file_name: 2019_NewPhytologist_Pickup.pdf
file_size: 1511958
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 224'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1035-1047
pmid: 1
project:
- _id: 25B36484-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '329960'
name: Mating system and the evolutionary dynamics of hybrid zones
- _id: 2662AADE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02463
name: Sex chromosomes and species barriers
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Mating system variation in hybrid zones: Facilitation, barriers and asymmetries
to gene flow'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 224
year: '2019'
...
---
_id: '6857'
abstract:
- lang: eng
text: "Gene Drives are regarded as future tools with a high potential for population
control. Due to their inherent ability to overcome the rules of Mendelian inheritance,
gene drives (GD) may spread genes rapidly through populations of sexually reproducing
organisms. A release of organisms carrying a GD would constitute a paradigm shift
in the handling of genetically modified organisms because gene drive organisms
(GDO) are designed to drive their transgenes into wild populations and thereby
increase the number of GDOs. The rapid development in this field and its focus
on wild populations demand a prospective risk assessment with a focus on exposure
related aspects. Presently, it is unclear how adequate risk management could be
guaranteed to limit the spread of GDs in time and space, in order to avoid potential
adverse effects in socio‐ecological systems.\r\n\r\nThe recent workshop on the
“Evaluation of Spatial and Temporal Control of Gene Drives” hosted by the Institute
of Safety/Security and Risk Sciences (ISR) in Vienna aimed at gaining some insight
into the potential population dynamic behavior of GDs and appropriate measures
of control. Scientists from France, Germany, England, and the USA discussed both
topics in this meeting on April 4–5, 2019. This article summarizes results of
the workshop."
article_number: '1900151'
article_processing_charge: No
article_type: original
author:
- first_name: B
full_name: Giese, B
last_name: Giese
- first_name: J L
full_name: Friess, J L
last_name: Friess
- first_name: 'M F '
full_name: 'Schetelig, M F '
last_name: Schetelig
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Philip
full_name: Messer, Philip
last_name: Messer
- first_name: Florence
full_name: Debarre, Florence
last_name: Debarre
- first_name: H
full_name: Meimberg, H
last_name: Meimberg
- first_name: N
full_name: Windbichler, N
last_name: Windbichler
- first_name: C
full_name: Boete, C
last_name: Boete
citation:
ama: 'Giese B, Friess JL, Schetelig MF, et al. Gene Drives: Dynamics and regulatory
matters – A report from the workshop “Evaluation of spatial and temporal control
of Gene Drives”, 4 – 5 April 2019, Vienna. BioEssays. 2019;41(11). doi:10.1002/bies.201900151'
apa: 'Giese, B., Friess, J. L., Schetelig, M. F., Barton, N. H., Messer, P., Debarre,
F., … Boete, C. (2019). Gene Drives: Dynamics and regulatory matters – A report
from the workshop “Evaluation of spatial and temporal control of Gene Drives”,
4 – 5 April 2019, Vienna. BioEssays. Wiley. https://doi.org/10.1002/bies.201900151'
chicago: 'Giese, B, J L Friess, M F Schetelig, Nicholas H Barton, Philip Messer,
Florence Debarre, H Meimberg, N Windbichler, and C Boete. “Gene Drives: Dynamics
and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and
Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” BioEssays.
Wiley, 2019. https://doi.org/10.1002/bies.201900151.'
ieee: 'B. Giese et al., “Gene Drives: Dynamics and regulatory matters – A
report from the workshop ‘Evaluation of spatial and temporal control of Gene Drives’,
4 – 5 April 2019, Vienna,” BioEssays, vol. 41, no. 11. Wiley, 2019.'
ista: 'Giese B, Friess JL, Schetelig MF, Barton NH, Messer P, Debarre F, Meimberg
H, Windbichler N, Boete C. 2019. Gene Drives: Dynamics and regulatory matters
– A report from the workshop “Evaluation of spatial and temporal control of Gene
Drives”, 4 – 5 April 2019, Vienna. BioEssays. 41(11), 1900151.'
mla: 'Giese, B., et al. “Gene Drives: Dynamics and Regulatory Matters – A Report
from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’,
4 – 5 April 2019, Vienna.” BioEssays, vol. 41, no. 11, 1900151, Wiley,
2019, doi:10.1002/bies.201900151.'
short: B. Giese, J.L. Friess, M.F. Schetelig, N.H. Barton, P. Messer, F. Debarre,
H. Meimberg, N. Windbichler, C. Boete, BioEssays 41 (2019).
date_created: 2019-09-07T14:40:03Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-30T06:56:26Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/bies.201900151
external_id:
isi:
- '000489502000001'
file:
- access_level: open_access
checksum: 8cc7551bff70b2658f8d5630f228ee12
content_type: application/pdf
creator: dernst
date_created: 2019-10-11T06:59:26Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6939'
file_name: 2019_BioEssays_Giese.pdf
file_size: 193248
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 41'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: BioEssays
publication_identifier:
eissn:
- 1521-1878
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Gene Drives: Dynamics and regulatory matters – A report from the workshop
“Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2019'
...
---
_id: '6858'
article_processing_charge: No
article_type: review
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Is speciation driven by cycles of mixing and isolation? National
Science Review. 2019;6(2):291-292. doi:10.1093/nsr/nwy113
apa: Barton, N. H. (2019). Is speciation driven by cycles of mixing and isolation?
National Science Review. Oxford University Press. https://doi.org/10.1093/nsr/nwy113
chicago: Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?”
National Science Review. Oxford University Press, 2019. https://doi.org/10.1093/nsr/nwy113.
ieee: N. H. Barton, “Is speciation driven by cycles of mixing and isolation?,” National
Science Review, vol. 6, no. 2. Oxford University Press, pp. 291–292, 2019.
ista: Barton NH. 2019. Is speciation driven by cycles of mixing and isolation? National
Science Review. 6(2), 291–292.
mla: Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?”
National Science Review, vol. 6, no. 2, Oxford University Press, 2019,
pp. 291–92, doi:10.1093/nsr/nwy113.
short: N.H. Barton, National Science Review 6 (2019) 291–292.
date_created: 2019-09-07T14:43:02Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2023-08-29T07:51:09Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/nsr/nwy113
external_id:
isi:
- '000467957400025'
file:
- access_level: open_access
checksum: 571d60fa21a568607d1fd04e119da88c
content_type: application/pdf
creator: dernst
date_created: 2020-10-02T09:16:44Z
date_updated: 2020-10-02T09:16:44Z
file_id: '8595'
file_name: 2019_NSR_Barton.pdf
file_size: 106463
relation: main_file
success: 1
file_date_updated: 2020-10-02T09:16:44Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '2'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 291-292
publication: National Science Review
publication_identifier:
eissn:
- 2053-714X
issn:
- 2095-5138
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Is speciation driven by cycles of mixing and isolation?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2019'
...
---
_id: '6859'
abstract:
- lang: eng
text: V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found
in archaeaand eubacteria, couple ATP hydrolysis or synthesis to proton translocation
across theplasma membrane using the rotary-catalysis mechanism. They belong to
the V-typeATPase family, which differs from the mitochondrial/chloroplast F-type
ATP synthasesin overall architecture. We solved cryo–electron microscopy structures
of the intactThermus thermophilusV/A-ATPase, reconstituted into lipid nanodiscs,
in three rotationalstates and two substates. These structures indicate substantial
flexibility betweenV1and Voin a working enzyme, which results from mechanical
competition between centralshaft rotation and resistance from the peripheral stalks.
We also describedetails of adenosine diphosphate inhibition release, V1-Votorque
transmission, andproton translocation, which are relevant for the entire V-type
ATPase family.
acknowledged_ssus:
- _id: ScienComp
article_number: eaaw9144
article_processing_charge: No
author:
- first_name: Long
full_name: Zhou, Long
id: 3E751364-F248-11E8-B48F-1D18A9856A87
last_name: Zhou
orcid: 0000-0002-1864-8951
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus
thermophilus V/A-type ATPase. Science. 2019;365(6455). doi:10.1126/science.aaw9144
apa: Zhou, L., & Sazanov, L. A. (2019). Structure and conformational plasticity
of the intact Thermus thermophilus V/A-type ATPase. Science. AAAS. https://doi.org/10.1126/science.aaw9144
chicago: Zhou, Long, and Leonid A Sazanov. “Structure and Conformational Plasticity
of the Intact Thermus Thermophilus V/A-Type ATPase.” Science. AAAS, 2019.
https://doi.org/10.1126/science.aaw9144.
ieee: L. Zhou and L. A. Sazanov, “Structure and conformational plasticity of the
intact Thermus thermophilus V/A-type ATPase,” Science, vol. 365, no. 6455.
AAAS, 2019.
ista: Zhou L, Sazanov LA. 2019. Structure and conformational plasticity of the intact
Thermus thermophilus V/A-type ATPase. Science. 365(6455), eaaw9144.
mla: Zhou, Long, and Leonid A. Sazanov. “Structure and Conformational Plasticity
of the Intact Thermus Thermophilus V/A-Type ATPase.” Science, vol. 365,
no. 6455, eaaw9144, AAAS, 2019, doi:10.1126/science.aaw9144.
short: L. Zhou, L.A. Sazanov, Science 365 (2019).
date_created: 2019-09-07T19:04:45Z
date_published: 2019-08-23T00:00:00Z
date_updated: 2023-08-29T07:52:02Z
day: '23'
department:
- _id: LeSa
doi: 10.1126/science.aaw9144
external_id:
isi:
- '000482464000043'
pmid:
- '31439765'
intvolume: ' 365'
isi: 1
issue: '6455'
language:
- iso: eng
month: '08'
oa_version: None
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- description: News on IST Website
relation: press_release
url: https://ist.ac.at/en/news/structure-of-protein-nano-turbine-revealed/
scopus_import: '1'
status: public
title: Structure and conformational plasticity of the intact Thermus thermophilus
V/A-type ATPase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 365
year: '2019'
...