---
_id: '11954'
abstract:
- lang: eng
text: The combination of nickel and photocatalysis has unlocked a variety of cross-couplings.
These protocols rely on a few photocatalysts that can only convert a small portion
of visible light (<500 nm) into chemical energy. The high-energy photons that
excite the photocatalyst can result in unwanted side reactions. Dyes that absorb
a much broader spectrum of light are not applicable because of their short-lived
singlet excited states. Here, we describe a self-assembling catalyst system that
overcomes this limitation. Immobilization of a nickel catalyst on dye-sensitized
titanium dioxide results in a material that catalyzes carbon–heteroatom and carbon–carbon
bond formations. The modular approach of dye-sensitized metallaphotocatalysts
accesses the entire visible light spectrum and allows tackling selectivity issues
resulting from low wavelengths strategically. The concept overcomes current limitations
of metallaphotocatalysis by unlocking the potential of dyes that were previously
unsuitable.
article_processing_charge: No
article_type: original
author:
- first_name: Susanne
full_name: Reischauer, Susanne
last_name: Reischauer
- first_name: Volker
full_name: Strauss, Volker
last_name: Strauss
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Reischauer S, Strauss V, Pieber B. Modular, self-assembling metallaphotocatalyst
for cross-couplings using the full visible-light spectrum. ACS Catalysis.
2020;10(22):13269–13274. doi:10.1021/acscatal.0c03950
apa: Reischauer, S., Strauss, V., & Pieber, B. (2020). Modular, self-assembling
metallaphotocatalyst for cross-couplings using the full visible-light spectrum.
ACS Catalysis. American Chemical Society. https://doi.org/10.1021/acscatal.0c03950
chicago: Reischauer, Susanne, Volker Strauss, and Bartholomäus Pieber. “Modular,
Self-Assembling Metallaphotocatalyst for Cross-Couplings Using the Full Visible-Light
Spectrum.” ACS Catalysis. American Chemical Society, 2020. https://doi.org/10.1021/acscatal.0c03950.
ieee: S. Reischauer, V. Strauss, and B. Pieber, “Modular, self-assembling metallaphotocatalyst
for cross-couplings using the full visible-light spectrum,” ACS Catalysis,
vol. 10, no. 22. American Chemical Society, pp. 13269–13274, 2020.
ista: Reischauer S, Strauss V, Pieber B. 2020. Modular, self-assembling metallaphotocatalyst
for cross-couplings using the full visible-light spectrum. ACS Catalysis. 10(22),
13269–13274.
mla: Reischauer, Susanne, et al. “Modular, Self-Assembling Metallaphotocatalyst
for Cross-Couplings Using the Full Visible-Light Spectrum.” ACS Catalysis,
vol. 10, no. 22, American Chemical Society, 2020, pp. 13269–13274, doi:10.1021/acscatal.0c03950.
short: S. Reischauer, V. Strauss, B. Pieber, ACS Catalysis 10 (2020) 13269–13274.
date_created: 2022-08-24T10:40:46Z
date_published: 2020-11-02T00:00:00Z
date_updated: 2023-02-21T10:09:09Z
day: '02'
doi: 10.1021/acscatal.0c03950
extern: '1'
intvolume: ' 10'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.26434/chemrxiv.12444908
month: '11'
oa: 1
oa_version: Preprint
page: 13269–13274
publication: ACS Catalysis
publication_identifier:
eissn:
- 2155-5435
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modular, self-assembling metallaphotocatalyst for cross-couplings using the
full visible-light spectrum
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2020'
...
---
_id: '11966'
abstract:
- lang: eng
text: The front cover artwork is provided by the group of Dr. Bartholomäus Pieber
at the Max Planck Institute of Colloids and Interfaces (Germany). The image symbolizes
the activation of a heterogeneous photocatalyst by visible light and its application
for organic synthesis. Read the full text of the Review at 10.1002/cptc.202000014.
article_processing_charge: No
article_type: original
author:
- first_name: Sebastian
full_name: Gisbertz, Sebastian
last_name: Gisbertz
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Gisbertz S, Pieber B. Heterogeneous photocatalysis in organic synthesis. ChemPhotoChem.
2020;4(7):454-454. doi:10.1002/cptc.202000137
apa: Gisbertz, S., & Pieber, B. (2020). Heterogeneous photocatalysis in organic
synthesis. ChemPhotoChem. Wiley. https://doi.org/10.1002/cptc.202000137
chicago: Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis
in Organic Synthesis.” ChemPhotoChem. Wiley, 2020. https://doi.org/10.1002/cptc.202000137.
ieee: S. Gisbertz and B. Pieber, “Heterogeneous photocatalysis in organic synthesis,”
ChemPhotoChem, vol. 4, no. 7. Wiley, pp. 454–454, 2020.
ista: Gisbertz S, Pieber B. 2020. Heterogeneous photocatalysis in organic synthesis.
ChemPhotoChem. 4(7), 454–454.
mla: Gisbertz, Sebastian, and Bartholomäus Pieber. “Heterogeneous Photocatalysis
in Organic Synthesis.” ChemPhotoChem, vol. 4, no. 7, Wiley, 2020, pp. 454–454,
doi:10.1002/cptc.202000137.
short: S. Gisbertz, B. Pieber, ChemPhotoChem 4 (2020) 454–454.
date_created: 2022-08-25T08:33:38Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-02-21T10:09:40Z
day: '01'
doi: 10.1002/cptc.202000137
extern: '1'
intvolume: ' 4'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 454-454
publication: ChemPhotoChem
publication_identifier:
eissn:
- 2367-0932
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Heterogeneous photocatalysis in organic synthesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2020'
...
---
_id: '11969'
abstract:
- lang: eng
text: Photochemistry enables new synthetic means to form carbon–heteroatom bonds.
Photocatalysts can catalyze carbon–heteroatom cross-couplings by electron or energy
transfer either alone or in combination with a second catalyst. Photocatalyst-free
methods are possible using photolabile substrates or by generating photoactive
electron donor-acceptor complexes. This review summarizes and discusses the strategies
used in light-mediated carbon–heteroatom bond formations based on the proposed
mechanisms.
article_processing_charge: No
article_type: review
author:
- first_name: Cristian
full_name: Cavedon, Cristian
last_name: Cavedon
- first_name: Peter H.
full_name: Seeberger, Peter H.
last_name: Seeberger
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Cavedon C, Seeberger PH, Pieber B. Photochemical strategies for carbon–heteroatom
bond formation. European Journal of Organic Chemistry. 2020;2020(10):1379-1392.
doi:10.1002/ejoc.201901173
apa: Cavedon, C., Seeberger, P. H., & Pieber, B. (2020). Photochemical strategies
for carbon–heteroatom bond formation. European Journal of Organic Chemistry.
Wiley. https://doi.org/10.1002/ejoc.201901173
chicago: Cavedon, Cristian, Peter H. Seeberger, and Bartholomäus Pieber. “Photochemical
Strategies for Carbon–Heteroatom Bond Formation.” European Journal of Organic
Chemistry. Wiley, 2020. https://doi.org/10.1002/ejoc.201901173.
ieee: C. Cavedon, P. H. Seeberger, and B. Pieber, “Photochemical strategies for
carbon–heteroatom bond formation,” European Journal of Organic Chemistry,
vol. 2020, no. 10. Wiley, pp. 1379–1392, 2020.
ista: Cavedon C, Seeberger PH, Pieber B. 2020. Photochemical strategies for carbon–heteroatom
bond formation. European Journal of Organic Chemistry. 2020(10), 1379–1392.
mla: Cavedon, Cristian, et al. “Photochemical Strategies for Carbon–Heteroatom Bond
Formation.” European Journal of Organic Chemistry, vol. 2020, no. 10, Wiley,
2020, pp. 1379–92, doi:10.1002/ejoc.201901173.
short: C. Cavedon, P.H. Seeberger, B. Pieber, European Journal of Organic Chemistry
2020 (2020) 1379–1392.
date_created: 2022-08-25T08:49:25Z
date_published: 2020-03-15T00:00:00Z
date_updated: 2023-02-21T10:09:47Z
day: '15'
doi: 10.1002/ejoc.201901173
extern: '1'
intvolume: ' 2020'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/ejoc.201901173
month: '03'
oa: 1
oa_version: Published Version
page: 1379-1392
publication: European Journal of Organic Chemistry
publication_identifier:
eissn:
- 1099-0690
issn:
- 1434-193X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Photochemical strategies for carbon–heteroatom bond formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2020
year: '2020'
...
---
_id: '11978'
abstract:
- lang: eng
text: Dual photocatalysis and nickel catalysis can effect cross-coupling under mild
conditions, but little is known about the in situ kinetics of this class of reactions.
We report a comprehensive kinetic examination of a model carboxylate O-arylation,
comparing a state-of-the-art homogeneous photocatalyst (Ir(ppy)3) with a competitive
heterogeneous photocatalyst (graphitic carbon nitride). Experimental conditions
were adjusted such that the nickel catalytic cycle is saturated with excited photocatalyst.
This approach was designed to remove the role of the photocatalyst, by which only
the intrinsic behaviors of the nickel catalytic cycles are observed. The two reactions
did not display identical kinetics. Ir(ppy)3 deactivates the nickel catalytic
cycle and creates more dehalogenated side product. Kinetic data for the reaction
using Ir(ppy)3 supports a turnover-limiting reductive elimination. Graphitic carbon
nitride gave higher selectivity, even at high photocatalyst-to-nickel ratios.
The heterogeneous reaction also showed a rate dependence on aryl halide, indicating
that oxidative addition plays a role in rate determination. The results argue
against the current mechanistic hypothesis, which states that the photocatalyst
is only involved to trigger reductive elimination.
article_processing_charge: No
article_type: original
author:
- first_name: Jamal A.
full_name: Malik, Jamal A.
last_name: Malik
- first_name: Amiera
full_name: Madani, Amiera
last_name: Madani
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Peter H.
full_name: Seeberger, Peter H.
last_name: Seeberger
citation:
ama: Malik JA, Madani A, Pieber B, Seeberger PH. Evidence for photocatalyst involvement
in oxidative additions of nickel-catalyzed carboxylate O-arylations. Journal
of the American Chemical Society. 2020;142(25):11042-11049. doi:10.1021/jacs.0c02848
apa: Malik, J. A., Madani, A., Pieber, B., & Seeberger, P. H. (2020). Evidence
for photocatalyst involvement in oxidative additions of nickel-catalyzed carboxylate
O-arylations. Journal of the American Chemical Society. American Chemical
Society. https://doi.org/10.1021/jacs.0c02848
chicago: Malik, Jamal A., Amiera Madani, Bartholomäus Pieber, and Peter H. Seeberger.
“Evidence for Photocatalyst Involvement in Oxidative Additions of Nickel-Catalyzed
Carboxylate O-Arylations.” Journal of the American Chemical Society. American
Chemical Society, 2020. https://doi.org/10.1021/jacs.0c02848.
ieee: J. A. Malik, A. Madani, B. Pieber, and P. H. Seeberger, “Evidence for photocatalyst
involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations,”
Journal of the American Chemical Society, vol. 142, no. 25. American Chemical
Society, pp. 11042–11049, 2020.
ista: Malik JA, Madani A, Pieber B, Seeberger PH. 2020. Evidence for photocatalyst
involvement in oxidative additions of nickel-catalyzed carboxylate O-arylations.
Journal of the American Chemical Society. 142(25), 11042–11049.
mla: Malik, Jamal A., et al. “Evidence for Photocatalyst Involvement in Oxidative
Additions of Nickel-Catalyzed Carboxylate O-Arylations.” Journal of the American
Chemical Society, vol. 142, no. 25, American Chemical Society, 2020, pp. 11042–49,
doi:10.1021/jacs.0c02848.
short: J.A. Malik, A. Madani, B. Pieber, P.H. Seeberger, Journal of the American
Chemical Society 142 (2020) 11042–11049.
date_created: 2022-08-25T10:57:38Z
date_published: 2020-06-24T00:00:00Z
date_updated: 2023-02-21T10:10:06Z
day: '24'
doi: 10.1021/jacs.0c02848
extern: '1'
external_id:
pmid:
- '32469219'
intvolume: ' 142'
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1021/jacs.0c02848
month: '06'
oa: 1
oa_version: Published Version
page: 11042-11049
pmid: 1
publication: Journal of the American Chemical Society
publication_identifier:
eissn:
- 1520-5126
issn:
- 0002-7863
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evidence for photocatalyst involvement in oxidative additions of nickel-catalyzed
carboxylate O-arylations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 142
year: '2020'
...
---
_id: '11979'
abstract:
- lang: eng
text: Dual photoredox/nickel-catalysed C–N cross-couplings suffer from low yields
for electron-rich aryl halides. The formation of catalytically inactive nickel-black
is responsible for this limitation and causes severe reproducibility issues. Here,
we demonstrate that catalyst deactivation can be avoided by using a carbon nitride
photocatalyst. The broad absorption of the heterogeneous photocatalyst enables
wavelength-dependent control of the rate of reductive elimination to prevent nickel-black
formation during the coupling of cyclic, secondary amines and aryl halides. A
second approach, which is applicable to a broader set of electron-rich aryl halides,
is to run the reactions at high concentrations to increase the rate of oxidative
addition. Less nucleophilic, primary amines can be coupled with electron-rich
aryl halides by stabilizing low-valent nickel intermediates with a suitable additive.
The developed protocols enable reproducible, selective C–N cross-couplings of
electron-rich aryl bromides and can also be applied for electron-poor aryl chlorides.
article_processing_charge: No
article_type: original
author:
- first_name: Sebastian
full_name: Gisbertz, Sebastian
last_name: Gisbertz
- first_name: Susanne
full_name: Reischauer, Susanne
last_name: Reischauer
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
citation:
ama: Gisbertz S, Reischauer S, Pieber B. Overcoming limitations in dual photoredox/nickel-catalysed
C–N cross-couplings due to catalyst deactivation. Nature Catalysis. 2020;3(8):611-620.
doi:10.1038/s41929-020-0473-6
apa: Gisbertz, S., Reischauer, S., & Pieber, B. (2020). Overcoming limitations
in dual photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation.
Nature Catalysis. Springer Nature. https://doi.org/10.1038/s41929-020-0473-6
chicago: Gisbertz, Sebastian, Susanne Reischauer, and Bartholomäus Pieber. “Overcoming
Limitations in Dual Photoredox/Nickel-Catalysed C–N Cross-Couplings Due to Catalyst
Deactivation.” Nature Catalysis. Springer Nature, 2020. https://doi.org/10.1038/s41929-020-0473-6.
ieee: S. Gisbertz, S. Reischauer, and B. Pieber, “Overcoming limitations in dual
photoredox/nickel-catalysed C–N cross-couplings due to catalyst deactivation,”
Nature Catalysis, vol. 3, no. 8. Springer Nature, pp. 611–620, 2020.
ista: Gisbertz S, Reischauer S, Pieber B. 2020. Overcoming limitations in dual photoredox/nickel-catalysed
C–N cross-couplings due to catalyst deactivation. Nature Catalysis. 3(8), 611–620.
mla: Gisbertz, Sebastian, et al. “Overcoming Limitations in Dual Photoredox/Nickel-Catalysed
C–N Cross-Couplings Due to Catalyst Deactivation.” Nature Catalysis, vol.
3, no. 8, Springer Nature, 2020, pp. 611–20, doi:10.1038/s41929-020-0473-6.
short: S. Gisbertz, S. Reischauer, B. Pieber, Nature Catalysis 3 (2020) 611–620.
date_created: 2022-08-25T11:06:16Z
date_published: 2020-08-01T00:00:00Z
date_updated: 2023-02-21T10:10:09Z
day: '01'
doi: 10.1038/s41929-020-0473-6
extern: '1'
intvolume: ' 3'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.26434/chemrxiv.10298735
month: '08'
oa: 1
oa_version: Preprint
page: 611-620
publication: Nature Catalysis
publication_identifier:
eissn:
- 2520-1158
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Overcoming limitations in dual photoredox/nickel-catalysed C–N cross-couplings
due to catalyst deactivation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2020'
...
---
_id: '11980'
abstract:
- lang: eng
text: Small organic radicals are ubiquitous intermediates in photocatalysis and
are used in organic synthesis to install functional groups and to tune electronic
properties and pharmacokinetic parameters of the final molecule. Development of
new methods to generate small organic radicals with added functionality can further
extend the utility of photocatalysis for synthetic needs. Herein, we present a
method to generate dichloromethyl radicals from chloroform using a heterogeneous
potassium poly(heptazine imide) (K-PHI) photocatalyst under visible light irradiation
for C1-extension of the enone backbone. The method is applied on 15 enones, with
γ,γ-dichloroketones yields of 18–89%. Due to negative zeta-potential (−40 mV)
and small particle size (100 nm) K-PHI suspension is used in quasi-homogeneous
flow-photoreactor increasing the productivity by 19 times compared to the batch
approach. The resulting γ,γ-dichloroketones, are used as bifunctional building
blocks to access value-added organic compounds such as substituted furans and
pyrroles.
article_number: '1387'
article_processing_charge: No
article_type: original
author:
- first_name: Stefano
full_name: Mazzanti, Stefano
last_name: Mazzanti
- first_name: Bogdan
full_name: Kurpil, Bogdan
last_name: Kurpil
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: Markus
full_name: Antonietti, Markus
last_name: Antonietti
- first_name: Aleksandr
full_name: Savateev, Aleksandr
last_name: Savateev
citation:
ama: Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. Dichloromethylation
of enones by carbon nitride photocatalysis. Nature Communications. 2020;11.
doi:10.1038/s41467-020-15131-0
apa: Mazzanti, S., Kurpil, B., Pieber, B., Antonietti, M., & Savateev, A. (2020).
Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-020-15131-0
chicago: Mazzanti, Stefano, Bogdan Kurpil, Bartholomäus Pieber, Markus Antonietti,
and Aleksandr Savateev. “Dichloromethylation of Enones by Carbon Nitride Photocatalysis.”
Nature Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-15131-0.
ieee: S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, and A. Savateev, “Dichloromethylation
of enones by carbon nitride photocatalysis,” Nature Communications, vol.
11. Springer Nature, 2020.
ista: Mazzanti S, Kurpil B, Pieber B, Antonietti M, Savateev A. 2020. Dichloromethylation
of enones by carbon nitride photocatalysis. Nature Communications. 11, 1387.
mla: Mazzanti, Stefano, et al. “Dichloromethylation of Enones by Carbon Nitride
Photocatalysis.” Nature Communications, vol. 11, 1387, Springer Nature,
2020, doi:10.1038/s41467-020-15131-0.
short: S. Mazzanti, B. Kurpil, B. Pieber, M. Antonietti, A. Savateev, Nature Communications
11 (2020).
date_created: 2022-08-25T11:10:15Z
date_published: 2020-03-13T00:00:00Z
date_updated: 2023-02-21T10:10:14Z
day: '13'
doi: 10.1038/s41467-020-15131-0
extern: '1'
intvolume: ' 11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-020-15131-0
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dichloromethylation of enones by carbon nitride photocatalysis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '11986'
abstract:
- lang: eng
text: Carbon nitride materials have emerged as an efficient and sustainable class
of heterogeneous photocatalysts, particularly when paired with nickel in dual
catalytic cross-coupling reactions. Performing these transformations on larger
scales using a continuous process is difficult due to the problems associated
with handling solids in flow. By combining an oscillatory pump with a microstructured
plug flow photoreactor, a stable suspension of the photocatalyst can be maintained,
circumventing clogging of the reactor channels. Through careful tuning of the
oscillator properties, the residence time distribution (RTD) was optimized, whilst
maintaining a stable catalyst suspension. Short residence times (20 min) were
achieved using optimized conditions and the recyclability of the photocatalyst
was demonstrated over 10 cycles with no loss of activity. During a stable 4.5
hour scale-out demonstration, the model substrate could be isolated on 12 g scale
(90% yield, 2.67 g h−1). Moreover, the method was applied for the gram scale synthesis
of an intermediate of the active pharmaceutical ingredient tetracaine.
article_processing_charge: No
article_type: original
author:
- first_name: Cristian
full_name: Rosso, Cristian
last_name: Rosso
- first_name: Sebastian
full_name: Gisbertz, Sebastian
last_name: Gisbertz
- first_name: Jason D.
full_name: Williams, Jason D.
last_name: Williams
- first_name: Hannes P. L.
full_name: Gemoets, Hannes P. L.
last_name: Gemoets
- first_name: Wouter
full_name: Debrouwer, Wouter
last_name: Debrouwer
- first_name: Bartholomäus
full_name: Pieber, Bartholomäus
id: 93e5e5b2-0da6-11ed-8a41-af589a024726
last_name: Pieber
orcid: 0000-0001-8689-388X
- first_name: C. Oliver
full_name: Kappe, C. Oliver
last_name: Kappe
citation:
ama: Rosso C, Gisbertz S, Williams JD, et al. An oscillatory plug flow photoreactor
facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings.
Reaction Chemistry and Engineering. 2020;5(3):597-604. doi:10.1039/d0re00036a
apa: Rosso, C., Gisbertz, S., Williams, J. D., Gemoets, H. P. L., Debrouwer, W.,
Pieber, B., & Kappe, C. O. (2020). An oscillatory plug flow photoreactor facilitates
semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction
Chemistry and Engineering. Royal Society of Chemistry. https://doi.org/10.1039/d0re00036a
chicago: Rosso, Cristian, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets,
Wouter Debrouwer, Bartholomäus Pieber, and C. Oliver Kappe. “An Oscillatory Plug
Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic
C–N Couplings.” Reaction Chemistry and Engineering. Royal Society of Chemistry,
2020. https://doi.org/10.1039/d0re00036a.
ieee: C. Rosso et al., “An oscillatory plug flow photoreactor facilitates
semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings,” Reaction
Chemistry and Engineering, vol. 5, no. 3. Royal Society of Chemistry, pp.
597–604, 2020.
ista: Rosso C, Gisbertz S, Williams JD, Gemoets HPL, Debrouwer W, Pieber B, Kappe
CO. 2020. An oscillatory plug flow photoreactor facilitates semi-heterogeneous
dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and
Engineering. 5(3), 597–604.
mla: Rosso, Cristian, et al. “An Oscillatory Plug Flow Photoreactor Facilitates
Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” Reaction
Chemistry and Engineering, vol. 5, no. 3, Royal Society of Chemistry, 2020,
pp. 597–604, doi:10.1039/d0re00036a.
short: C. Rosso, S. Gisbertz, J.D. Williams, H.P.L. Gemoets, W. Debrouwer, B. Pieber,
C.O. Kappe, Reaction Chemistry and Engineering 5 (2020) 597–604.
date_created: 2022-08-25T11:45:02Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-02-21T10:10:28Z
day: '01'
doi: 10.1039/d0re00036a
extern: '1'
intvolume: ' 5'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1039/D0RE00036A
month: '03'
oa: 1
oa_version: Published Version
page: 597-604
publication: Reaction Chemistry and Engineering
publication_identifier:
eissn:
- 2058-9883
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon
nitride photocatalytic C–N couplings
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2020'
...
---
_id: '12190'
abstract:
- lang: eng
text: Meiotic crossover frequency varies within genomes, which influences genetic
diversity and adaptation. In turn, genetic variation within populations can act
to modify crossover frequency in cis and trans. To identify genetic variation
that controls meiotic crossover frequency, we screened Arabidopsis accessions
using fluorescent recombination reporters. We mapped a genetic modifier of crossover
frequency in Col × Bur populations of Arabidopsis to a premature stop codon within
TBP-ASSOCIATED FACTOR 4b (TAF4b), which encodes a subunit of the RNA polymerase
II general transcription factor TFIID. The Arabidopsis taf4b mutation is a rare
variant found in the British Isles, originating in South-West Ireland. Using genetics,
genomics, and immunocytology, we demonstrate a genome-wide decrease in taf4b crossovers,
with strongest reduction in the sub-telomeric regions. Using RNA sequencing (RNA-seq)
from purified meiocytes, we show that TAF4b expression is meiocyte enriched, whereas
its paralog TAF4 is broadly expressed. Consistent with the role of TFIID in promoting
gene expression, RNA-seq of wild-type and taf4b meiocytes identified widespread
transcriptional changes, including in genes that regulate the meiotic cell cycle
and recombination. Therefore, TAF4b duplication is associated with acquisition
of meiocyte-specific expression and promotion of germline transcription, which
act directly or indirectly to elevate crossovers. This identifies a novel mode
of meiotic recombination control via a general transcription factor.
acknowledgement: "We thank Gregory Copenhaver (University of North Carolina), Avraham
Levy (The Weizmann Institute), and Scott Poethig (University of Pennsylvania) for
FTLs; Piotr Ziolkowski for Col-420/Bur seed; Sureshkumar Balasubramanian\r\n(Monash
University) for providing British and Irish Arabidopsis accessions; Mathilde Grelon
(INRA, Versailles) for providing the MLH1 antibody; and the Gurdon Institute for
access to microscopes. This work was supported by a BBSRC DTP studentship (E.J.L.),
European Research Area Network for Coordinating Action in Plant Sciences/BBSRC ‘‘DeCOP’’
(BB/M004937/1; C.L.), a BBSRC David Phillips Fellowship (BB/L025043/1; H.G. and
X.F.), the European Research Council (CoG ‘‘SynthHotspot,’’ A.J.T., C.L., and I.R.H.;
StG ‘‘SexMeth,’’ X.F.), and a Sainsbury Charitable Foundation Studentship (A.R.B.)."
article_processing_charge: No
article_type: original
author:
- first_name: Emma J.
full_name: Lawrence, Emma J.
last_name: Lawrence
- first_name: Hongbo
full_name: Gao, Hongbo
last_name: Gao
- first_name: Andrew J.
full_name: Tock, Andrew J.
last_name: Tock
- first_name: Christophe
full_name: Lambing, Christophe
last_name: Lambing
- first_name: Alexander R.
full_name: Blackwell, Alexander R.
last_name: Blackwell
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Ian R.
full_name: Henderson, Ian R.
last_name: Henderson
citation:
ama: Lawrence EJ, Gao H, Tock AJ, et al. Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis. Current
Biology. 2019;29(16):2676-2686.e3. doi:10.1016/j.cub.2019.06.084
apa: Lawrence, E. J., Gao, H., Tock, A. J., Lambing, C., Blackwell, A. R., Feng,
X., & Henderson, I. R. (2019). Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis. Current
Biology. Elsevier BV. https://doi.org/10.1016/j.cub.2019.06.084
chicago: Lawrence, Emma J., Hongbo Gao, Andrew J. Tock, Christophe Lambing, Alexander
R. Blackwell, Xiaoqi Feng, and Ian R. Henderson. “Natural Variation in TBP-ASSOCIATED
FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.”
Current Biology. Elsevier BV, 2019. https://doi.org/10.1016/j.cub.2019.06.084.
ieee: E. J. Lawrence et al., “Natural variation in TBP-ASSOCIATED FACTOR
4b controls meiotic crossover and germline transcription in Arabidopsis,” Current
Biology, vol. 29, no. 16. Elsevier BV, p. 2676–2686.e3, 2019.
ista: Lawrence EJ, Gao H, Tock AJ, Lambing C, Blackwell AR, Feng X, Henderson IR.
2019. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover
and germline transcription in Arabidopsis. Current Biology. 29(16), 2676–2686.e3.
mla: Lawrence, Emma J., et al. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls
Meiotic Crossover and Germline Transcription in Arabidopsis.” Current Biology,
vol. 29, no. 16, Elsevier BV, 2019, p. 2676–2686.e3, doi:10.1016/j.cub.2019.06.084.
short: E.J. Lawrence, H. Gao, A.J. Tock, C. Lambing, A.R. Blackwell, X. Feng, I.R.
Henderson, Current Biology 29 (2019) 2676–2686.e3.
date_created: 2023-01-16T09:16:33Z
date_published: 2019-08-19T00:00:00Z
date_updated: 2023-05-08T10:54:54Z
day: '19'
department:
- _id: XiFe
doi: 10.1016/j.cub.2019.06.084
extern: '1'
external_id:
pmid:
- '31378616'
intvolume: ' 29'
issue: '16'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '08'
oa_version: None
page: 2676-2686.e3
pmid: 1
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and
germline transcription in Arabidopsis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2019'
...
---
_id: '12192'
abstract:
- lang: eng
text: Transposable elements (TEs), the movement of which can damage the genome,
are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in
the sperm companion cell – vegetative cell (VC) – of the flowering plant Arabidopsis
thaliana. However, the extent and mechanism of this activation are unknown. Here
we show that about 100 heterochromatic TEs are activated in VCs, mostly by DEMETER-catalyzed
DNA demethylation. We further demonstrate that DEMETER access to some of these
TEs is permitted by the natural depletion of linker histone H1 in VCs. Ectopically
expressed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent
mechanism. We demonstrate that H1 is required for heterochromatin condensation
in plant cells and show that H1 overexpression creates heterochromatic foci in
the VC progenitor cell. Taken together, our results demonstrate that the natural
depletion of H1 during male gametogenesis facilitates DEMETER-directed DNA demethylation,
heterochromatin relaxation, and TE activation.
acknowledgement: We thank David Twell for the pDONR-P4-P1R-pLAT52 and pDONR-P2R-P3-mRFP
vectors, the John Innes Centre Bioimaging Facility (Elaine Barclay and Grant Calder)
for their assistance with microscopy, and the Norwich BioScience Institute Partnership
Computing infrastructure for Science Group for High Performance Computing resources.
This work was funded by a Biotechnology and Biological Sciences Research Council
(BBSRC) David Phillips Fellowship (BB/L025043/1; SH, JZ and XF), a European Research
Council Starting Grant ('SexMeth' 804981; XF) and a Grant to Exceptional Researchers
by the Gatsby Charitable Foundation (SH and XF).
article_number: '42530'
article_processing_charge: No
article_type: original
author:
- first_name: Shengbo
full_name: He, Shengbo
last_name: He
- first_name: Martin
full_name: Vickers, Martin
last_name: Vickers
- first_name: Jingyi
full_name: Zhang, Jingyi
last_name: Zhang
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
citation:
ama: He S, Vickers M, Zhang J, Feng X. Natural depletion of histone H1 in sex cells
causes DNA demethylation, heterochromatin decondensation and transposon activation.
eLife. 2019;8. doi:10.7554/elife.42530
apa: He, S., Vickers, M., Zhang, J., & Feng, X. (2019). Natural depletion of
histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation
and transposon activation. ELife. eLife Sciences Publications, Ltd. https://doi.org/10.7554/elife.42530
chicago: He, Shengbo, Martin Vickers, Jingyi Zhang, and Xiaoqi Feng. “Natural Depletion
of Histone H1 in Sex Cells Causes DNA Demethylation, Heterochromatin Decondensation
and Transposon Activation.” ELife. eLife Sciences Publications, Ltd, 2019.
https://doi.org/10.7554/elife.42530.
ieee: S. He, M. Vickers, J. Zhang, and X. Feng, “Natural depletion of histone H1
in sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation,” eLife, vol. 8. eLife Sciences Publications, Ltd, 2019.
ista: He S, Vickers M, Zhang J, Feng X. 2019. Natural depletion of histone H1 in
sex cells causes DNA demethylation, heterochromatin decondensation and transposon
activation. eLife. 8, 42530.
mla: He, Shengbo, et al. “Natural Depletion of Histone H1 in Sex Cells Causes DNA
Demethylation, Heterochromatin Decondensation and Transposon Activation.” ELife,
vol. 8, 42530, eLife Sciences Publications, Ltd, 2019, doi:10.7554/elife.42530.
short: S. He, M. Vickers, J. Zhang, X. Feng, ELife 8 (2019).
date_created: 2023-01-16T09:17:21Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2023-05-08T10:54:12Z
day: '28'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.7554/elife.42530
extern: '1'
external_id:
unknown:
- '31135340'
file:
- access_level: open_access
checksum: ea6b89c20d59e5eb3646916fe5d568ad
content_type: application/pdf
creator: alisjak
date_created: 2023-02-07T09:42:46Z
date_updated: 2023-02-07T09:42:46Z
file_id: '12525'
file_name: 2019_elife_He.pdf
file_size: 2493837
relation: main_file
success: 1
file_date_updated: 2023-02-07T09:42:46Z
has_accepted_license: '1'
intvolume: ' 8'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594752/
month: '05'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications, Ltd
quality_controlled: '1'
scopus_import: '1'
status: public
title: Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin
decondensation and transposon activation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2019'
...
---
_id: '12600'
abstract:
- lang: eng
text: The snow cover dynamics of High Mountain Asia are usually assessed at spatial
resolutions of 250 m or greater, but this scale is too coarse to clearly represent
the rugged topography common to the region. Higher-resolution measurement of snow-covered
area often results in biased sampling due to cloud cover and deep shadows. We
therefore develop a Normalized Difference Snow Index-based workflow to delineate
snow lines from Landsat Thematic Mapper/Enhanced Thematic Mapper+ imagery and
apply it to the upper Langtang Valley in Nepal, processing 194 scenes spanning
1999 to 2013. For each scene, we determine the spatial distribution of snow line
altitudes (SLAs) with respect to aspect and across six subcatchments. Our results
show that the mean SLA exhibits distinct seasonal behavior based on aspect and
subcatchment position. We find that SLA dynamics respond to spatial and seasonal
trade-offs in precipitation, temperature, and solar radiation, which act as primary
controls. We identify two SLA spatial gradients, which we attribute to the effect
of spatially variable precipitation. Our results also reveal that aspect-related
SLA differences vary seasonally and are influenced by solar radiation. In terms
of seasonal dominant controls, we demonstrate that the snow line is controlled
by snow precipitation in winter, melt in premonsoon, a combination of both in
postmonsoon, and temperature in monsoon, explaining to a large extent the spatial
and seasonal variability of the SLA in the upper Langtang Valley. We conclude
that while SLA and snow-covered area are complementary metrics, the SLA has a
strong potential for understanding local-scale snow cover dynamics and their controlling
mechanisms.
article_processing_charge: No
article_type: original
author:
- first_name: Marc
full_name: Girona‐Mata, Marc
last_name: Girona‐Mata
- first_name: Evan S.
full_name: Miles, Evan S.
last_name: Miles
- first_name: Silvan
full_name: Ragettli, Silvan
last_name: Ragettli
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: Girona‐Mata M, Miles ES, Ragettli S, Pellicciotti F. High‐resolution snowline
delineation from Landsat imagery to infer snow cover controls in a Himalayan catchment.
Water Resources Research. 2019;55(8):6754-6772. doi:10.1029/2019wr024935
apa: Girona‐Mata, M., Miles, E. S., Ragettli, S., & Pellicciotti, F. (2019).
High‐resolution snowline delineation from Landsat imagery to infer snow cover
controls in a Himalayan catchment. Water Resources Research. American Geophysical
Union. https://doi.org/10.1029/2019wr024935
chicago: Girona‐Mata, Marc, Evan S. Miles, Silvan Ragettli, and Francesca Pellicciotti.
“High‐resolution Snowline Delineation from Landsat Imagery to Infer Snow Cover
Controls in a Himalayan Catchment.” Water Resources Research. American
Geophysical Union, 2019. https://doi.org/10.1029/2019wr024935.
ieee: M. Girona‐Mata, E. S. Miles, S. Ragettli, and F. Pellicciotti, “High‐resolution
snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan
catchment,” Water Resources Research, vol. 55, no. 8. American Geophysical
Union, pp. 6754–6772, 2019.
ista: Girona‐Mata M, Miles ES, Ragettli S, Pellicciotti F. 2019. High‐resolution
snowline delineation from Landsat imagery to infer snow cover controls in a Himalayan
catchment. Water Resources Research. 55(8), 6754–6772.
mla: Girona‐Mata, Marc, et al. “High‐resolution Snowline Delineation from Landsat
Imagery to Infer Snow Cover Controls in a Himalayan Catchment.” Water Resources
Research, vol. 55, no. 8, American Geophysical Union, 2019, pp. 6754–72, doi:10.1029/2019wr024935.
short: M. Girona‐Mata, E.S. Miles, S. Ragettli, F. Pellicciotti, Water Resources
Research 55 (2019) 6754–6772.
date_created: 2023-02-20T08:12:59Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-02-28T12:14:18Z
day: '01'
doi: 10.1029/2019wr024935
extern: '1'
intvolume: ' 55'
issue: '8'
keyword:
- Water Science and Technology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1029/2019WR024935
month: '08'
oa: 1
oa_version: Published Version
page: 6754-6772
publication: Water Resources Research
publication_identifier:
eissn:
- 1944-7973
issn:
- 0043-1397
publication_status: published
publisher: American Geophysical Union
quality_controlled: '1'
scopus_import: '1'
status: public
title: High‐resolution snowline delineation from Landsat imagery to infer snow cover
controls in a Himalayan catchment
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2019'
...
---
_id: '12601'
abstract:
- lang: eng
text: Ice cliffs and ponds on debris-covered glaciers have received increased attention
due to their role in amplifying local melt. However, very few studies have looked
at these features on the catchment scale to determine their patterns and changes
in space and time. We have compiled a detailed inventory of cliffs and ponds in
the Langtang catchment, central Himalaya, from six high-resolution satellite orthoimages
and DEMs between 2006 and 2015, and a historic orthophoto from 1974. Cliffs cover
between 1.4% (± 0.4%) in the dry and 3.4% (± 0.9%) in the wet seasons and ponds
between 0.6% (± 0.1%) and 1.6% (± 0.3%) of the total debris-covered tongues. We
find large variations between seasons, as cliffs and ponds tend to grow in the
wetter monsoon period, but there is no obvious trend in total area over the study
period. The inventory further shows that cliffs are predominately north-facing
irrespective of the glacier flow direction. Both cliffs and ponds appear in higher
densities several hundred metres from the terminus in areas where tributaries
reach the main glacier tongue. On the largest glacier in the catchment ~10% of
all cliffs and ponds persisted over nearly a decade.
article_processing_charge: No
article_type: original
author:
- first_name: JAKOB F.
full_name: STEINER, JAKOB F.
last_name: STEINER
- first_name: PASCAL
full_name: BURI, PASCAL
last_name: BURI
- first_name: EVAN S.
full_name: MILES, EVAN S.
last_name: MILES
- first_name: SILVAN
full_name: RAGETTLI, SILVAN
last_name: RAGETTLI
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
citation:
ama: 'STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. Supraglacial ice
cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution and
characteristics. Journal of Glaciology. 2019;65(252):617-632. doi:10.1017/jog.2019.40'
apa: 'STEINER, J. F., BURI, P., MILES, E. S., RAGETTLI, S., & Pellicciotti,
F. (2019). Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal
distribution and characteristics. Journal of Glaciology. Cambridge University
Press. https://doi.org/10.1017/jog.2019.40'
chicago: 'STEINER, JAKOB F., PASCAL BURI, EVAN S. MILES, SILVAN RAGETTLI, and Francesca
Pellicciotti. “Supraglacial Ice Cliffs and Ponds on Debris-Covered Glaciers: Spatio-Temporal
Distribution and Characteristics.” Journal of Glaciology. Cambridge University
Press, 2019. https://doi.org/10.1017/jog.2019.40.'
ieee: 'J. F. STEINER, P. BURI, E. S. MILES, S. RAGETTLI, and F. Pellicciotti, “Supraglacial
ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution
and characteristics,” Journal of Glaciology, vol. 65, no. 252. Cambridge
University Press, pp. 617–632, 2019.'
ista: 'STEINER JF, BURI P, MILES ES, RAGETTLI S, Pellicciotti F. 2019. Supraglacial
ice cliffs and ponds on debris-covered glaciers: Spatio-temporal distribution
and characteristics. Journal of Glaciology. 65(252), 617–632.'
mla: 'STEINER, JAKOB F., et al. “Supraglacial Ice Cliffs and Ponds on Debris-Covered
Glaciers: Spatio-Temporal Distribution and Characteristics.” Journal of Glaciology,
vol. 65, no. 252, Cambridge University Press, 2019, pp. 617–32, doi:10.1017/jog.2019.40.'
short: J.F. STEINER, P. BURI, E.S. MILES, S. RAGETTLI, F. Pellicciotti, Journal
of Glaciology 65 (2019) 617–632.
date_created: 2023-02-20T08:13:03Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2023-02-28T12:11:07Z
day: '01'
doi: 10.1017/jog.2019.40
extern: '1'
intvolume: ' 65'
issue: '252'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1017/jog.2019.40
month: '08'
oa: 1
oa_version: Published Version
page: 617-632
publication: Journal of Glaciology
publication_identifier:
eissn:
- 1727-5652
issn:
- 0022-1430
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Supraglacial ice cliffs and ponds on debris-covered glaciers: Spatio-temporal
distribution and characteristics'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 65
year: '2019'
...
---
_id: '12602'
abstract:
- lang: eng
text: 'This study aims at developing and applying a spatially-distributed coupled
glacier mass balance and ice-flow model to attribute the response of glaciers
to natural and anthropogenic climate change. We focus on two glaciers with contrasting
surface characteristics: a debris-covered glacier (Langtang Glacier in Nepal)
and a clean-ice glacier (Hintereisferner in Austria). The model is applied from
the end of the Little Ice Age (1850) to the present-day (2016) and is forced with
four bias-corrected General Circulation Models (GCMs) from the historical experiment
of the CMIP5 archive. The selected GCMs represent region-specific warm-dry, warm-wet,
cold-dry, and cold-wet climate conditions. To isolate the effects of anthropogenic
climate change on glacier mass balance and flow runs from these GCMs with and
without further anthropogenic forcing after 1970 until 2016 are selected. The
outcomes indicate that both glaciers experience the largest reduction in area
and volume under warm climate conditions, whereas area and volume reductions are
smaller under cold climate conditions. Simultaneously with changes in glacier
area and volume, surface velocities generally decrease over time. Without further
anthropogenic forcing the results reveal a 3% (9%) smaller decline in glacier
area (volume) for the debris-covered glacier and a 18% (39%) smaller decline in
glacier area (volume) for the clean-ice glacier. The difference in the magnitude
between the two glaciers can mainly be attributed to differences in the response
time of the glaciers, where the clean-ice glacier shows a much faster response
to climate change. We conclude that the response of the two glaciers can mainly
be attributed to anthropogenic climate change and that the impact is larger on
the clean-ice glacier. The outcomes show that the model performs well under different
climate conditions and that the developed approach can be used for regional-scale
glacio-hydrological modeling.'
article_number: '143'
article_processing_charge: No
article_type: original
author:
- first_name: René R.
full_name: Wijngaard, René R.
last_name: Wijngaard
- first_name: Jakob F.
full_name: Steiner, Jakob F.
last_name: Steiner
- first_name: Philip D. A.
full_name: Kraaijenbrink, Philip D. A.
last_name: Kraaijenbrink
- first_name: Christoph
full_name: Klug, Christoph
last_name: Klug
- first_name: Surendra
full_name: Adhikari, Surendra
last_name: Adhikari
- first_name: Argha
full_name: Banerjee, Argha
last_name: Banerjee
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Ludovicus P. H.
full_name: van Beek, Ludovicus P. H.
last_name: van Beek
- first_name: Marc F. P.
full_name: Bierkens, Marc F. P.
last_name: Bierkens
- first_name: Arthur F.
full_name: Lutz, Arthur F.
last_name: Lutz
- first_name: Walter W.
full_name: Immerzeel, Walter W.
last_name: Immerzeel
citation:
ama: Wijngaard RR, Steiner JF, Kraaijenbrink PDA, et al. Modeling the response of
the Langtang Glacier and the Hintereisferner to a changing climate since the Little
Ice Age. Frontiers in Earth Science. 2019;7. doi:10.3389/feart.2019.00143
apa: Wijngaard, R. R., Steiner, J. F., Kraaijenbrink, P. D. A., Klug, C., Adhikari,
S., Banerjee, A., … Immerzeel, W. W. (2019). Modeling the response of the Langtang
Glacier and the Hintereisferner to a changing climate since the Little Ice Age.
Frontiers in Earth Science. Frontiers Media. https://doi.org/10.3389/feart.2019.00143
chicago: Wijngaard, René R., Jakob F. Steiner, Philip D. A. Kraaijenbrink, Christoph
Klug, Surendra Adhikari, Argha Banerjee, Francesca Pellicciotti, et al. “Modeling
the Response of the Langtang Glacier and the Hintereisferner to a Changing Climate
since the Little Ice Age.” Frontiers in Earth Science. Frontiers Media,
2019. https://doi.org/10.3389/feart.2019.00143.
ieee: R. R. Wijngaard et al., “Modeling the response of the Langtang Glacier
and the Hintereisferner to a changing climate since the Little Ice Age,” Frontiers
in Earth Science, vol. 7. Frontiers Media, 2019.
ista: Wijngaard RR, Steiner JF, Kraaijenbrink PDA, Klug C, Adhikari S, Banerjee
A, Pellicciotti F, van Beek LPH, Bierkens MFP, Lutz AF, Immerzeel WW. 2019. Modeling
the response of the Langtang Glacier and the Hintereisferner to a changing climate
since the Little Ice Age. Frontiers in Earth Science. 7, 143.
mla: Wijngaard, René R., et al. “Modeling the Response of the Langtang Glacier and
the Hintereisferner to a Changing Climate since the Little Ice Age.” Frontiers
in Earth Science, vol. 7, 143, Frontiers Media, 2019, doi:10.3389/feart.2019.00143.
short: R.R. Wijngaard, J.F. Steiner, P.D.A. Kraaijenbrink, C. Klug, S. Adhikari,
A. Banerjee, F. Pellicciotti, L.P.H. van Beek, M.F.P. Bierkens, A.F. Lutz, W.W.
Immerzeel, Frontiers in Earth Science 7 (2019).
date_created: 2023-02-20T08:13:08Z
date_published: 2019-06-04T00:00:00Z
date_updated: 2023-02-28T12:04:48Z
day: '04'
doi: 10.3389/feart.2019.00143
extern: '1'
intvolume: ' 7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3389/feart.2019.00143
month: '06'
oa: 1
oa_version: Published Version
publication: Frontiers in Earth Science
publication_identifier:
issn:
- 2296-6463
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling the response of the Langtang Glacier and the Hintereisferner to a
changing climate since the Little Ice Age
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2019'
...
---
_id: '12901'
article_processing_charge: No
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Janos
full_name: Kiss, Janos
id: 3D3A06F8-F248-11E8-B48F-1D18A9856A87
last_name: Kiss
- first_name: Stefano
full_name: Elefante, Stefano
id: 490F40CE-F248-11E8-B48F-1D18A9856A87
last_name: Elefante
citation:
ama: 'Schlögl A, Kiss J, Elefante S. Is Debian suitable for running an HPC Cluster?
In: AHPC19 - Austrian HPC Meeting 2019 . Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz; 2019:25.'
apa: 'Schlögl, A., Kiss, J., & Elefante, S. (2019). Is Debian suitable for running
an HPC Cluster? In AHPC19 - Austrian HPC Meeting 2019 (p. 25). Grundlsee,
Austria: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz.'
chicago: Schlögl, Alois, Janos Kiss, and Stefano Elefante. “Is Debian Suitable for
Running an HPC Cluster?” In AHPC19 - Austrian HPC Meeting 2019 , 25. Institut
für Mathematik und wissenschaftliches Rechnen der Universität Graz, 2019.
ieee: A. Schlögl, J. Kiss, and S. Elefante, “Is Debian suitable for running an HPC
Cluster?,” in AHPC19 - Austrian HPC Meeting 2019 , Grundlsee, Austria,
2019, p. 25.
ista: 'Schlögl A, Kiss J, Elefante S. 2019. Is Debian suitable for running an HPC
Cluster? AHPC19 - Austrian HPC Meeting 2019 . AHPC: Austrian HPC Meeting, 25.'
mla: Schlögl, Alois, et al. “Is Debian Suitable for Running an HPC Cluster?” AHPC19
- Austrian HPC Meeting 2019 , Institut für Mathematik und wissenschaftliches
Rechnen der Universität Graz, 2019, p. 25.
short: A. Schlögl, J. Kiss, S. Elefante, in:, AHPC19 - Austrian HPC Meeting 2019
, Institut für Mathematik und wissenschaftliches Rechnen der Universität Graz,
2019, p. 25.
conference:
end_date: 2019-02-27
location: Grundlsee, Austria
name: 'AHPC: Austrian HPC Meeting'
start_date: 2019-02-25
date_created: 2023-05-05T12:48:48Z
date_published: 2019-02-27T00:00:00Z
date_updated: 2023-05-16T07:29:32Z
day: '27'
ddc:
- '000'
department:
- _id: ScienComp
file:
- access_level: open_access
checksum: acc8272027faaf30709c51ac5c58ffa4
content_type: application/pdf
creator: dernst
date_created: 2023-05-16T07:27:09Z
date_updated: 2023-05-16T07:27:09Z
file_id: '12970'
file_name: 2019_AHPC_Schloegl.pdf
file_size: 1097603
relation: main_file
success: 1
file_date_updated: 2023-05-16T07:27:09Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ahpc19/BOOKLET_AHPC19.pdf
month: '02'
oa: 1
oa_version: Published Version
page: '25'
publication: 'AHPC19 - Austrian HPC Meeting 2019 '
publication_status: published
publisher: Institut für Mathematik und wissenschaftliches Rechnen der Universität
Graz
status: public
title: Is Debian suitable for running an HPC Cluster?
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '13067'
abstract:
- lang: eng
text: Genetic incompatibilities contribute to reproductive isolation between many
diverging populations, but it is still unclear to what extent they play a role
if divergence happens with gene flow. In contact zones between the "Crab" and
"Wave" ecotypes of the snail Littorina saxatilis divergent selection forms strong
barriers to gene flow, while the role of postzygotic barriers due to selection
against hybrids remains unclear. High embryo abortion rates in this species could
indicate the presence of such barriers. Postzygotic barriers might include genetic
incompatibilities (e.g. Dobzhansky-Muller incompatibilities) but also maladaptation,
both expected to be most pronounced in contact zones. In addition, embryo abortion
might reflect physiological stress on females and embryos independent of any genetic
stress. We examined all embryos of >500 females sampled outside and inside
contact zones of three populations in Sweden. Females' clutch size ranged from
0 to 1011 embryos (mean 130±123) and abortion rates varied between 0 and100% (mean
12%). We described female genotypes by using a hybrid index based on hundreds
of SNPs differentiated between ecotypes with which we characterised female genotypes.
We also calculated female SNP heterozygosity and inversion karyotype. Clutch size
did not vary with female hybrid index and abortion rates were only weakly related
to hybrid index in two sites but not at all in a third site. No additional variation
in abortion rate was explained by female SNP heterozygosity, but increased female
inversion heterozygosity added slightly to increased abortion. Our results show
only weak and probably biologically insignificant postzygotic barriers contributing
to ecotype divergence and the high and variable abortion rates were marginally,
if at all, explained by hybrid index of females.
article_processing_charge: No
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Zuzanna
full_name: Zagrodzka, Zuzanna
last_name: Zagrodzka
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. Data from: Is embryo
abortion a postzygotic barrier to gene flow between Littorina ecotypes? 2019.
doi:10.5061/DRYAD.TB2RBNZWK'
apa: 'Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., & Butlin, R.
(2019). Data from: Is embryo abortion a postzygotic barrier to gene flow between
Littorina ecotypes? Dryad. https://doi.org/10.5061/DRYAD.TB2RBNZWK'
chicago: 'Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and
Roger Butlin. “Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow
between Littorina Ecotypes?” Dryad, 2019. https://doi.org/10.5061/DRYAD.TB2RBNZWK.'
ieee: 'K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. Butlin, “Data
from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?” Dryad, 2019.'
ista: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. 2019. Data from:
Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?,
Dryad, 10.5061/DRYAD.TB2RBNZWK.'
mla: 'Johannesson, Kerstin, et al. Data from: Is Embryo Abortion a Postzygotic
Barrier to Gene Flow between Littorina Ecotypes? Dryad, 2019, doi:10.5061/DRYAD.TB2RBNZWK.'
short: K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R. Butlin, (2019).
date_created: 2023-05-23T16:36:27Z
date_published: 2019-12-02T00:00:00Z
date_updated: 2023-09-06T14:48:57Z
day: '02'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.TB2RBNZWK
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.tb2rbnzwk
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '7205'
relation: used_in_publication
status: public
status: public
title: 'Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '13079'
abstract:
- lang: eng
text: The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum
(ER) that is gated by the nuclear pore complex. It is unknown whether proteins
of the INM and ER are degraded through shared or distinct pathways in mammalian
cells. We applied dynamic proteomics to profile protein half-lives and report
that INM and ER residents turn over at similar rates, indicating that the INM’s
unique topology is not a barrier to turnover. Using a microscopy approach, we
observed that the proteasome can degrade INM proteins in situ. However, we also
uncovered evidence for selective, vesicular transport-mediated turnover of a single
INM protein, emerin, that is potentiated by ER stress. Emerin is rapidly cleared
from the INM by a mechanism that requires emerin’s LEM domain to mediate vesicular
trafficking to lysosomes. This work demonstrates that the INM can be dynamically
remodeled in response to environmental inputs.
article_processing_charge: No
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Roberta
full_name: Schulte, Roberta
last_name: Schulte
- first_name: Hsiao
full_name: Tsai, Hsiao
last_name: Tsai
- first_name: Juliana
full_name: Capitanio, Juliana
last_name: Capitanio
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Data from: Selective
clearance of the inner nuclear membrane protein emerin by vesicular transport
during ER stress. 2019. doi:10.5061/DRYAD.N0R525H'
apa: 'Buchwalter, A., Schulte, R., Tsai, H., Capitanio, J., & Hetzer, M. (2019).
Data from: Selective clearance of the inner nuclear membrane protein emerin by
vesicular transport during ER stress. Dryad. https://doi.org/10.5061/DRYAD.N0R525H'
chicago: 'Buchwalter, Abigail, Roberta Schulte, Hsiao Tsai, Juliana Capitanio, and
Martin Hetzer. “Data from: Selective Clearance of the Inner Nuclear Membrane Protein
Emerin by Vesicular Transport during ER Stress.” Dryad, 2019. https://doi.org/10.5061/DRYAD.N0R525H.'
ieee: 'A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, and M. Hetzer, “Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress.” Dryad, 2019.'
ista: 'Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. 2019. Data from:
Selective clearance of the inner nuclear membrane protein emerin by vesicular
transport during ER stress, Dryad, 10.5061/DRYAD.N0R525H.'
mla: 'Buchwalter, Abigail, et al. Data from: Selective Clearance of the Inner
Nuclear Membrane Protein Emerin by Vesicular Transport during ER Stress. Dryad,
2019, doi:10.5061/DRYAD.N0R525H.'
short: A. Buchwalter, R. Schulte, H. Tsai, J. Capitanio, M. Hetzer, (2019).
date_created: 2023-05-23T17:09:30Z
date_published: 2019-10-28T00:00:00Z
date_updated: 2023-05-31T06:36:23Z
day: '28'
ddc:
- '570'
doi: 10.5061/DRYAD.N0R525H
extern: '1'
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.n0r525h
month: '10'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '11060'
relation: used_in_publication
status: public
status: public
title: 'Data from: Selective clearance of the inner nuclear membrane protein emerin
by vesicular transport during ER stress'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '8227'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Kristina M.
full_name: Ilieva, Kristina M.
last_name: Ilieva
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Heather J.
full_name: Bax, Heather J.
last_name: Bax
- first_name: Silvia
full_name: Crescioli, Silvia
last_name: Crescioli
- first_name: Laura
full_name: Montero‐Morales, Laura
last_name: Montero‐Morales
- first_name: Silvia
full_name: Mele, Silvia
last_name: Mele
- first_name: Heng Sheng
full_name: Sow, Heng Sheng
last_name: Sow
- first_name: Chara
full_name: Stavraka, Chara
last_name: Stavraka
- first_name: Debra H.
full_name: Josephs, Debra H.
last_name: Josephs
- first_name: James F.
full_name: Spicer, James F.
last_name: Spicer
- first_name: Herta
full_name: Steinkellner, Herta
last_name: Steinkellner
orcid: 0000-0003-4823-1505
- first_name: Erika
full_name: Jensen‐Jarolim, Erika
last_name: Jensen‐Jarolim
orcid: 0000-0003-4019-5765
- first_name: Andrew N. J.
full_name: Tutt, Andrew N. J.
last_name: Tutt
orcid: 0000-0001-8715-2901
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
orcid: 0000-0002-4100-7810
citation:
ama: 'Ilieva KM, Singer J, Bax HJ, et al. AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody. Allergy. 2019;74(10):1985-1989.
doi:10.1111/all.13818'
apa: 'Ilieva, K. M., Singer, J., Bax, H. J., Crescioli, S., Montero‐Morales, L.,
Mele, S., … Karagiannis, S. N. (2019). AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody. Allergy. Wiley.
https://doi.org/10.1111/all.13818'
chicago: 'Ilieva, Kristina M., Judit Singer, Heather J. Bax, Silvia Crescioli, Laura
Montero‐Morales, Silvia Mele, Heng Sheng Sow, et al. “AllergoOncology: Expression
Platform Development and Functional Profiling of an Anti‐HER2 IgE Antibody.” Allergy.
Wiley, 2019. https://doi.org/10.1111/all.13818.'
ieee: 'K. M. Ilieva et al., “AllergoOncology: Expression platform development
and functional profiling of an anti‐HER2 IgE antibody,” Allergy, vol. 74,
no. 10. Wiley, pp. 1985–1989, 2019.'
ista: 'Ilieva KM, Singer J, Bax HJ, Crescioli S, Montero‐Morales L, Mele S, Sow
HS, Stavraka C, Josephs DH, Spicer JF, Steinkellner H, Jensen‐Jarolim E, Tutt
ANJ, Karagiannis SN. 2019. AllergoOncology: Expression platform development and
functional profiling of an anti‐HER2 IgE antibody. Allergy. 74(10), 1985–1989.'
mla: 'Ilieva, Kristina M., et al. “AllergoOncology: Expression Platform Development
and Functional Profiling of an Anti‐HER2 IgE Antibody.” Allergy, vol. 74,
no. 10, Wiley, 2019, pp. 1985–89, doi:10.1111/all.13818.'
short: K.M. Ilieva, J. Singer, H.J. Bax, S. Crescioli, L. Montero‐Morales, S. Mele,
H.S. Sow, C. Stavraka, D.H. Josephs, J.F. Spicer, H. Steinkellner, E. Jensen‐Jarolim,
A.N.J. Tutt, S.N. Karagiannis, Allergy 74 (2019) 1985–1989.
date_created: 2020-08-10T11:50:42Z
date_published: 2019-10-01T00:00:00Z
date_updated: 2021-01-12T08:17:35Z
day: '01'
doi: 10.1111/all.13818
extern: '1'
intvolume: ' 74'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/all.13818
month: '10'
oa: 1
oa_version: Published Version
page: 1985-1989
publication: Allergy
publication_identifier:
issn:
- 0105-4538
- 1398-9995
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: 'AllergoOncology: Expression platform development and functional profiling
of an anti‐HER2 IgE antibody'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 74
year: '2019'
...
---
_id: '8228'
abstract:
- lang: eng
text: "Background: Atopics have a lower risk for malignancies, and IgE targeted
to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or
adaptive immune surveillance can confer protection against tumors remains unclear.\r\nObjective:
We aimed to investigate the effects of active and passive immunotherapy to the
tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor
expression affecting the levels of expressed IgE.\r\nMethods: We compared the
levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b,
IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic
domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1
mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated
serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2
mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle
control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated
with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy).\r\nResults:
Overall, among the three strains of mice, HER-2 vaccination induced significantly
higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while low-IgE ΔM1M2
mice had higher IgG2a levels. HER-2 vaccination and passive immunotherapy prolonged
the survival in tumor-grafted WT and low-IgE ΔM1M2 strains compared with treatment
controls; active vaccination provided the highest benefit. Notably, untreated
high-IgE KN1 mice displayed the longest survival of all strains, which could not
be further extended by active or passive immunotherapy.\r\nConclusion: Active
and passive immunotherapies prolong survival in wild type and low-IgE ΔM1M2 mice
engrafted with mammary tumors. High-IgE KN1 mice have an innate survival benefit
following tumor challenge."
article_number: '100044'
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Singer, Josef
last_name: Singer
orcid: 0000-0002-8701-2412
- first_name: Gertrude
full_name: Achatz-Straussberger, Gertrude
last_name: Achatz-Straussberger
- first_name: Anna
full_name: Bentley-Lukschal, Anna
last_name: Bentley-Lukschal
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Gernot
full_name: Achatz, Gernot
last_name: Achatz
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
citation:
ama: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, et al. AllergoOncology:
High innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. 2019;12(7). doi:10.1016/j.waojou.2019.100044'
apa: 'Singer, J., Achatz-Straussberger, G., Bentley-Lukschal, A., Singer, J., Achatz,
G., Karagiannis, S. N., & Jensen-Jarolim, E. (2019). AllergoOncology: High
innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. Elsevier. https://doi.org/10.1016/j.waojou.2019.100044'
chicago: 'Singer, Josef, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit
Singer, Gernot Achatz, Sophia N. Karagiannis, and Erika Jensen-Jarolim. “AllergoOncology:
High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.”
World Allergy Organization Journal. Elsevier, 2019. https://doi.org/10.1016/j.waojou.2019.100044.'
ieee: 'J. Singer et al., “AllergoOncology: High innate IgE levels are decisive
for the survival of cancer-bearing mice,” World Allergy Organization Journal,
vol. 12, no. 7. Elsevier, 2019.'
ista: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, Singer J, Achatz G,
Karagiannis SN, Jensen-Jarolim E. 2019. AllergoOncology: High innate IgE levels
are decisive for the survival of cancer-bearing mice. World Allergy Organization
Journal. 12(7), 100044.'
mla: 'Singer, Josef, et al. “AllergoOncology: High Innate IgE Levels Are Decisive
for the Survival of Cancer-Bearing Mice.” World Allergy Organization Journal,
vol. 12, no. 7, 100044, Elsevier, 2019, doi:10.1016/j.waojou.2019.100044.'
short: J. Singer, G. Achatz-Straussberger, A. Bentley-Lukschal, J. Singer, G. Achatz,
S.N. Karagiannis, E. Jensen-Jarolim, World Allergy Organization Journal 12 (2019).
date_created: 2020-08-10T11:50:54Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '29'
doi: 10.1016/j.waojou.2019.100044
extern: '1'
intvolume: ' 12'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.waojou.2019.100044
month: '07'
oa: 1
oa_version: Published Version
publication: World Allergy Organization Journal
publication_identifier:
issn:
- 1939-4551
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing
mice'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...
---
_id: '8229'
abstract:
- lang: eng
text: Food proteins may get nitrated by various exogenous or endogenous mechanisms.
As individuals might get recurrently exposed to nitrated proteins via daily diet,
we aimed to investigate the effect of repeatedly ingested nitrated food proteins
on the subsequent immune response in non-allergic and allergic mice using the
milk allergen beta-lactoglobulin (BLG) as model food protein in a mouse model.
Evaluating the presence of nitrated proteins in food, we could detect 3-nitrotyrosine
(3-NT) in extracts of different foods and in stomach content extracts of non-allergic
mice under physiological conditions. Chemically nitrated BLG (BLGn) exhibited
enhanced susceptibility to degradation in simulated gastric fluid experiments
compared to untreated BLG (BLGu). Gavage of BLGn to non-allergic animals increased
interferon-γ and interleukin-10 release of stimulated spleen cells and led to
the formation of BLG-specific serum IgA. Allergic mice receiving three oral gavages
of BLGn had higher levels of mouse mast cell protease-1 (mMCP-1) compared to allergic
mice receiving BLGu. Regardless of the preceding immune status, non-allergic or
allergic, repeatedly ingested nitrated food proteins seem to considerably influence
the subsequent immune response.
article_number: '2463'
article_processing_charge: No
article_type: original
author:
- first_name: Anna S.
full_name: Ondracek, Anna S.
last_name: Ondracek
orcid: 0000-0001-7625-3651
- first_name: Denise
full_name: Heiden, Denise
last_name: Heiden
- first_name: Gertie J.
full_name: Oostingh, Gertie J.
last_name: Oostingh
- first_name: Elisabeth
full_name: Fuerst, Elisabeth
last_name: Fuerst
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Cornelia
full_name: Bergmayr, Cornelia
last_name: Bergmayr
- first_name: Johanna
full_name: Rohrhofer, Johanna
last_name: Rohrhofer
orcid: 0000-0002-2783-2099
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
orcid: 0000-0003-4019-5765
- first_name: Albert
full_name: Duschl, Albert
last_name: Duschl
orcid: 0000-0002-7034-9860
- first_name: Eva
full_name: Untersmayr, Eva
last_name: Untersmayr
orcid: 0000-0002-1963-499X
citation:
ama: Ondracek AS, Heiden D, Oostingh GJ, et al. Immune effects of the nitrated food
allergen beta-lactoglobulin in an experimental food allergy model. Nutrients.
2019;11(10). doi:10.3390/nu11102463
apa: Ondracek, A. S., Heiden, D., Oostingh, G. J., Fuerst, E., Singer, J., Bergmayr,
C., … Untersmayr, E. (2019). Immune effects of the nitrated food allergen beta-lactoglobulin
in an experimental food allergy model. Nutrients. MDPI. https://doi.org/10.3390/nu11102463
chicago: Ondracek, Anna S., Denise Heiden, Gertie J. Oostingh, Elisabeth Fuerst,
Judit Singer, Cornelia Bergmayr, Johanna Rohrhofer, Erika Jensen-Jarolim, Albert
Duschl, and Eva Untersmayr. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
in an Experimental Food Allergy Model.” Nutrients. MDPI, 2019. https://doi.org/10.3390/nu11102463.
ieee: A. S. Ondracek et al., “Immune effects of the nitrated food allergen
beta-lactoglobulin in an experimental food allergy model,” Nutrients, vol.
11, no. 10. MDPI, 2019.
ista: Ondracek AS, Heiden D, Oostingh GJ, Fuerst E, Singer J, Bergmayr C, Rohrhofer
J, Jensen-Jarolim E, Duschl A, Untersmayr E. 2019. Immune effects of the nitrated
food allergen beta-lactoglobulin in an experimental food allergy model. Nutrients.
11(10), 2463.
mla: Ondracek, Anna S., et al. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
in an Experimental Food Allergy Model.” Nutrients, vol. 11, no. 10, 2463,
MDPI, 2019, doi:10.3390/nu11102463.
short: A.S. Ondracek, D. Heiden, G.J. Oostingh, E. Fuerst, J. Singer, C. Bergmayr,
J. Rohrhofer, E. Jensen-Jarolim, A. Duschl, E. Untersmayr, Nutrients 11 (2019).
date_created: 2020-08-10T11:51:04Z
date_published: 2019-10-15T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '15'
doi: 10.3390/nu11102463
extern: '1'
intvolume: ' 11'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.3390/nu11102463
month: '10'
oa: 1
oa_version: Published Version
publication: Nutrients
publication_identifier:
issn:
- 2072-6643
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental
food allergy model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...
---
_id: '8263'
abstract:
- lang: eng
text: "Background: The genus Streptococcus comprises pathogens that strongly influence
the health of humans and animals. Genome sequencing of multiple Streptococcus
strains demonstrated high variability in gene content and order even in closely
related strains of the same species and created a newly emerged object for genomic
analysis, the pan-genome. Here we analysed the genome evolution of 25 strains
of Streptococcus suis, 50 strains of Streptococcus pyogenes and 28 strains of
Streptococcus pneumoniae.\r\n\r\nResults: Fractions of the pan-genome, unique,
periphery, and universal genes differ in size, functional composition, the level
of nucleotide substitutions, and predisposition to horizontal gene transfer and
genomic rearrangements. The density of substitutions in intergenic regions appears
to be correlated with selection acting on adjacent genes, implying that more conserved
genes tend to have more conserved regulatory regions.\r\nThe total pan-genome
of the genus is open, but only due to strain-specific genes, whereas other pan-genome
fractions reach saturation. We have identified the set of genes with phylogenies
inconsistent with species and non-conserved location in the chromosome; these
genes are rare in at least one species and have likely experienced recent horizontal
transfer between species. The strain-specific fraction is enriched with mobile
elements and hypothetical proteins, but also contains a number of candidate virulence-related
genes, so it may have a strong impact on adaptability and pathogenicity.\r\nMapping
the rearrangements to the phylogenetic tree revealed large parallel inversions
in all species. A parallel inversion of length 15 kB with breakpoints formed by
genes encoding surface antigen proteins PhtD and PhtB in S. pneumoniae leads to
replacement of gene fragments that likely indicates the action of an antigen variation
mechanism.\r\n\r\nConclusions: Members of genus Streptococcus have a highly dynamic,
open pan-genome, that potentially confers them with the ability to adapt to changing
environmental conditions, i.e. antibiotic resistance or transmission between different
hosts. Hence, integrated analysis of all aspects of genome evolution is important
for the identification of potential pathogens and design of drugs and vaccines."
article_number: '83'
article_processing_charge: No
article_type: original
author:
- first_name: Pavel V.
full_name: Shelyakin, Pavel V.
last_name: Shelyakin
orcid: 0000-0003-0120-9319
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Anna A.
full_name: Karan, Anna A.
last_name: Karan
- first_name: Mikhail S.
full_name: Gelfand, Mikhail S.
last_name: Gelfand
citation:
ama: 'Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. Micro-evolution of three
Streptococcus species: Selection, antigenic variation, and horizontal gene inflow.
BMC Evolutionary Biology. 2019;19. doi:10.1186/s12862-019-1403-6'
apa: 'Shelyakin, P. V., Bochkareva, O., Karan, A. A., & Gelfand, M. S. (2019).
Micro-evolution of three Streptococcus species: Selection, antigenic variation,
and horizontal gene inflow. BMC Evolutionary Biology. Springer Nature.
https://doi.org/10.1186/s12862-019-1403-6'
chicago: 'Shelyakin, Pavel V., Olga Bochkareva, Anna A. Karan, and Mikhail S. Gelfand.
“Micro-Evolution of Three Streptococcus Species: Selection, Antigenic Variation,
and Horizontal Gene Inflow.” BMC Evolutionary Biology. Springer Nature,
2019. https://doi.org/10.1186/s12862-019-1403-6.'
ieee: 'P. V. Shelyakin, O. Bochkareva, A. A. Karan, and M. S. Gelfand, “Micro-evolution
of three Streptococcus species: Selection, antigenic variation, and horizontal
gene inflow,” BMC Evolutionary Biology, vol. 19. Springer Nature, 2019.'
ista: 'Shelyakin PV, Bochkareva O, Karan AA, Gelfand MS. 2019. Micro-evolution of
three Streptococcus species: Selection, antigenic variation, and horizontal gene
inflow. BMC Evolutionary Biology. 19, 83.'
mla: 'Shelyakin, Pavel V., et al. “Micro-Evolution of Three Streptococcus Species:
Selection, Antigenic Variation, and Horizontal Gene Inflow.” BMC Evolutionary
Biology, vol. 19, 83, Springer Nature, 2019, doi:10.1186/s12862-019-1403-6.'
short: P.V. Shelyakin, O. Bochkareva, A.A. Karan, M.S. Gelfand, BMC Evolutionary
Biology 19 (2019).
date_created: 2020-08-15T11:04:07Z
date_published: 2019-03-27T00:00:00Z
date_updated: 2023-02-23T13:28:54Z
day: '27'
doi: 10.1186/s12862-019-1403-6
extern: '1'
intvolume: ' 19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1186/s12862-019-1403-6
month: '03'
oa: 1
oa_version: Published Version
publication: BMC Evolutionary Biology
publication_identifier:
issn:
- 1471-2148
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'Micro-evolution of three Streptococcus species: Selection, antigenic variation,
and horizontal gene inflow'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2019'
...
---
_id: '8281'
abstract:
- lang: eng
text: We review the history of population genetics, starting with its origins a
century ago from the synthesis between Mendel and Darwin's ideas, through to the
recent development of sophisticated schemes of inference from sequence data, based
on the coalescent. We explain the close relation between the coalescent and a
diffusion process, which we illustrate by their application to understand spatial
structure. We summarise the powerful methods available for analysis of multiple
loci, when linkage equilibrium can be assumed, and then discuss approaches to
the more challenging case, where associations between alleles require that we
follow genotype, rather than allele, frequencies. Though we can hardly cover the
whole of population genetics, we give an overview of the current state of the
subject, and future challenges to it.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison
last_name: Etheridge
citation:
ama: 'Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding
D, Moltke I, Marioni J, eds. Handbook of Statistical Genomics. 4th ed.
Wiley; 2019:115-144. doi:10.1002/9781119487845.ch4'
apa: Barton, N. H., & Etheridge, A. (2019). Mathematical models in population
genetics. In D. Balding, I. Moltke, & J. Marioni (Eds.), Handbook of statistical
genomics (4th ed., pp. 115–144). Wiley. https://doi.org/10.1002/9781119487845.ch4
chicago: Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population
Genetics.” In Handbook of Statistical Genomics, edited by David Balding,
Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. https://doi.org/10.1002/9781119487845.ch4.
ieee: N. H. Barton and A. Etheridge, “Mathematical models in population genetics,”
in Handbook of statistical genomics, 4th ed., D. Balding, I. Moltke, and
J. Marioni, Eds. Wiley, 2019, pp. 115–144.
ista: 'Barton NH, Etheridge A. 2019.Mathematical models in population genetics.
In: Handbook of statistical genomics. , 115–144.'
mla: Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population
Genetics.” Handbook of Statistical Genomics, edited by David Balding et
al., 4th ed., Wiley, 2019, pp. 115–44, doi:10.1002/9781119487845.ch4.
short: N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.),
Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144.
date_created: 2020-08-21T04:25:39Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2023-09-08T11:24:15Z
day: '29'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1002/9781119487845.ch4
edition: '4'
editor:
- first_name: David
full_name: Balding, David
last_name: Balding
- first_name: Ida
full_name: Moltke, Ida
last_name: Moltke
- first_name: John
full_name: Marioni, John
last_name: Marioni
external_id:
isi:
- '000261343000003'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 115-144
publication: Handbook of statistical genomics
publication_identifier:
isbn:
- '9781119429142'
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Mathematical models in population genetics
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...