---
_id: '7665'
abstract:
- lang: eng
text: Acute brain slice preparation is a powerful experimental model for investigating
the characteristics of synaptic function in the brain. Although brain tissue is
usually cut at ice-cold temperature (CT) to facilitate slicing and avoid neuronal
damage, exposure to CT causes molecular and architectural changes of synapses.
To address these issues, we investigated ultrastructural and electrophysiological
features of synapses in mouse acute cerebellar slices prepared at ice-cold and
physiological temperature (PT). In the slices prepared at CT, we found significant
spine loss and reconstruction, synaptic vesicle rearrangement and decrease in
synaptic proteins, all of which were not detected in slices prepared at PT. Consistent
with these structural findings, slices prepared at PT showed higher release probability.
Furthermore, preparation at PT allows electrophysiological recording immediately
after slicing resulting in higher detectability of long-term depression (LTD)
after motor learning compared with that at CT. These results indicate substantial
advantages of the slice preparation at PT for investigating synaptic functions
in different physiological conditions.
article_number: '63'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Kohgaku
full_name: Eguchi, Kohgaku
id: 2B7846DC-F248-11E8-B48F-1D18A9856A87
last_name: Eguchi
orcid: 0000-0002-6170-2546
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Elena
full_name: Hollergschwandtner, Elena
id: 3C054040-F248-11E8-B48F-1D18A9856A87
last_name: Hollergschwandtner
- first_name: Makoto
full_name: Itakura, Makoto
last_name: Itakura
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Eguchi K, Velicky P, Saeckl E, et al. Advantages of acute brain slices prepared
at physiological temperature in the characterization of synaptic functions. Frontiers
in Cellular Neuroscience. 2020;14. doi:10.3389/fncel.2020.00063
apa: Eguchi, K., Velicky, P., Saeckl, E., Itakura, M., Fukazawa, Y., Danzl, J. G.,
& Shigemoto, R. (2020). Advantages of acute brain slices prepared at physiological
temperature in the characterization of synaptic functions. Frontiers in Cellular
Neuroscience. Frontiers Media. https://doi.org/10.3389/fncel.2020.00063
chicago: Eguchi, Kohgaku, Philipp Velicky, Elena Saeckl, Makoto Itakura, Yugo Fukazawa,
Johann G Danzl, and Ryuichi Shigemoto. “Advantages of Acute Brain Slices Prepared
at Physiological Temperature in the Characterization of Synaptic Functions.” Frontiers
in Cellular Neuroscience. Frontiers Media, 2020. https://doi.org/10.3389/fncel.2020.00063.
ieee: K. Eguchi et al., “Advantages of acute brain slices prepared at physiological
temperature in the characterization of synaptic functions,” Frontiers in Cellular
Neuroscience, vol. 14. Frontiers Media, 2020.
ista: Eguchi K, Velicky P, Saeckl E, Itakura M, Fukazawa Y, Danzl JG, Shigemoto
R. 2020. Advantages of acute brain slices prepared at physiological temperature
in the characterization of synaptic functions. Frontiers in Cellular Neuroscience.
14, 63.
mla: Eguchi, Kohgaku, et al. “Advantages of Acute Brain Slices Prepared at Physiological
Temperature in the Characterization of Synaptic Functions.” Frontiers in Cellular
Neuroscience, vol. 14, 63, Frontiers Media, 2020, doi:10.3389/fncel.2020.00063.
short: K. Eguchi, P. Velicky, E. Saeckl, M. Itakura, Y. Fukazawa, J.G. Danzl, R.
Shigemoto, Frontiers in Cellular Neuroscience 14 (2020).
date_created: 2020-04-19T22:00:55Z
date_published: 2020-03-19T00:00:00Z
date_updated: 2023-08-21T06:12:48Z
day: '19'
ddc:
- '570'
department:
- _id: JoDa
- _id: RySh
doi: 10.3389/fncel.2020.00063
ec_funded: 1
external_id:
isi:
- '000525582200001'
file:
- access_level: open_access
checksum: 1c145123c6f8dc3e2e4bd5a66a1ad60e
content_type: application/pdf
creator: dernst
date_created: 2020-04-20T10:59:49Z
date_updated: 2020-07-14T12:48:01Z
file_id: '7668'
file_name: 2020_FrontiersCellularNeurosc_Eguchi.pdf
file_size: 9227283
relation: main_file
file_date_updated: 2020-07-14T12:48:01Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 2659CC84-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '793482'
name: 'Ultrastructural analysis of phosphoinositides in nerve terminals: distribution,
dynamics and physiological roles in synaptic transmission'
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03600
name: Optical control of synaptic function via adhesion molecules
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Frontiers in Cellular Neuroscience
publication_identifier:
issn:
- '16625102'
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Advantages of acute brain slices prepared at physiological temperature in the
characterization of synaptic functions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2020'
...
---
_id: '7666'
abstract:
- lang: eng
text: Generalizing the decomposition of a connected planar graph into a tree and
a dual tree, we prove a combinatorial analog of the classic Helmholtz–Hodge decomposition
of a smooth vector field. Specifically, we show that for every polyhedral complex,
K, and every dimension, p, there is a partition of the set of p-cells into a maximal
p-tree, a maximal p-cotree, and a collection of p-cells whose cardinality is the
p-th reduced Betti number of K. Given an ordering of the p-cells, this tri-partition
is unique, and it can be computed by a matrix reduction algorithm that also constructs
canonical bases of cycle and boundary groups.
acknowledgement: This project has received funding from the European Research Council
under the European Union’s Horizon 2020 research and innovation programme (Grant
Agreement No. 78818 Alpha). It is also partially supported by the DFG Collaborative
Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through Grant
No. I02979-N35 of the Austrian Science Fund (FWF).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Katharina
full_name: Ölsböck, Katharina
id: 4D4AA390-F248-11E8-B48F-1D18A9856A87
last_name: Ölsböck
orcid: 0000-0002-4672-8297
citation:
ama: Edelsbrunner H, Ölsböck K. Tri-partitions and bases of an ordered complex.
Discrete and Computational Geometry. 2020;64:759-775. doi:10.1007/s00454-020-00188-x
apa: Edelsbrunner, H., & Ölsböck, K. (2020). Tri-partitions and bases of an
ordered complex. Discrete and Computational Geometry. Springer Nature.
https://doi.org/10.1007/s00454-020-00188-x
chicago: Edelsbrunner, Herbert, and Katharina Ölsböck. “Tri-Partitions and Bases
of an Ordered Complex.” Discrete and Computational Geometry. Springer Nature,
2020. https://doi.org/10.1007/s00454-020-00188-x.
ieee: H. Edelsbrunner and K. Ölsböck, “Tri-partitions and bases of an ordered complex,”
Discrete and Computational Geometry, vol. 64. Springer Nature, pp. 759–775,
2020.
ista: Edelsbrunner H, Ölsböck K. 2020. Tri-partitions and bases of an ordered complex.
Discrete and Computational Geometry. 64, 759–775.
mla: Edelsbrunner, Herbert, and Katharina Ölsböck. “Tri-Partitions and Bases of
an Ordered Complex.” Discrete and Computational Geometry, vol. 64, Springer
Nature, 2020, pp. 759–75, doi:10.1007/s00454-020-00188-x.
short: H. Edelsbrunner, K. Ölsböck, Discrete and Computational Geometry 64 (2020)
759–775.
date_created: 2020-04-19T22:00:56Z
date_published: 2020-03-20T00:00:00Z
date_updated: 2023-08-21T06:13:48Z
day: '20'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s00454-020-00188-x
ec_funded: 1
external_id:
isi:
- '000520918800001'
file:
- access_level: open_access
checksum: f8cc96e497f00c38340b5dafe0cb91d7
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T13:22:21Z
date_updated: 2020-11-20T13:22:21Z
file_id: '8786'
file_name: 2020_DiscreteCompGeo_Edelsbrunner.pdf
file_size: 701673
relation: main_file
success: 1
file_date_updated: 2020-11-20T13:22:21Z
has_accepted_license: '1'
intvolume: ' 64'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 759-775
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- '14320444'
issn:
- '01795376'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tri-partitions and bases of an ordered complex
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 64
year: '2020'
...
---
_id: '7672'
abstract:
- lang: eng
text: Large overpotentials upon discharge and charge of Li-O2 cells have motivated
extensive research into heterogeneous solid electrocatalysts or non-carbon electrodes
with the aim to improve rate capability, round-trip efficiency and cycle life.
These features are equally governed by parasitic reactions, which are now recognized
to be caused by the highly reactive singlet oxygen (1O2). However, the link between
the presence of electrocatalysts and 1O2 formation in metal-O2 cells is unknown.
Here, we show that, compared to pristine carbon black electrodes, a representative
selection of electrocatalysts or non-carbon electrodes (noble metal, transition
metal compounds) may both slightly reduce or severely increase the 1O2 formation.
The individual reaction steps, where the surfaces impact the 1O2 yield are deciphered,
showing that 1O2 yield from superoxide disproportionation as well as the decomposition
of trace H2O2 are sensitive to catalysts. Transition metal compounds in general
are prone to increase 1O2.
acknowledgement: S.A.F. thanks the International Society of Electrochemistry for awarding
the Tajima Prize 2019 “in recognition of outstanding re- searches on Li-Air batteries
by the use of a range of in-situ elec- trochemical methods to achieve comprehensive
understanding of the reactions taking place at the oxygen electrode”. This article
is dedicated to the special issue of Electrochmica Acta associated with the awarding
conference. S.A.F. is indebted to and the Austrian Federal Ministry of Science,
Research and Economy and the Austrian Research Promotion Agency (grant No. 845364
) and the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation programme (grant agreement No 636069). The authors thank
J. Schlegl for manufacturing instrumentation, M. Winkler of Acib GmbH and G. Strohmeier
for help with HPLC measurements, S. Eder for cyclic voltammetry measurements, and
C. Slugovc for discussions and continuous support. We thank S. Borisov for access
and advice with fluorescence measurements. We thank EL-Cell GmbH, Hamburg, Germany
for providing the PAT-Cell-Press electrochemical cell.
article_number: '137175'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Aleksej
full_name: Samojlov, Aleksej
last_name: Samojlov
- first_name: David
full_name: Schuster, David
last_name: Schuster
- first_name: Jürgen
full_name: Kahr, Jürgen
last_name: Kahr
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Samojlov A, Schuster D, Kahr J, Freunberger SA. Surface and catalyst driven
singlet oxygen formation in Li-O2 cells. Electrochimica Acta. 2020;362(12).
doi:10.1016/j.electacta.2020.137175
apa: Samojlov, A., Schuster, D., Kahr, J., & Freunberger, S. A. (2020). Surface
and catalyst driven singlet oxygen formation in Li-O2 cells. Electrochimica
Acta. Elsevier. https://doi.org/10.1016/j.electacta.2020.137175
chicago: Samojlov, Aleksej, David Schuster, Jürgen Kahr, and Stefan Alexander Freunberger.
“Surface and Catalyst Driven Singlet Oxygen Formation in Li-O2 Cells.” Electrochimica
Acta. Elsevier, 2020. https://doi.org/10.1016/j.electacta.2020.137175.
ieee: A. Samojlov, D. Schuster, J. Kahr, and S. A. Freunberger, “Surface and catalyst
driven singlet oxygen formation in Li-O2 cells,” Electrochimica Acta, vol.
362, no. 12. Elsevier, 2020.
ista: Samojlov A, Schuster D, Kahr J, Freunberger SA. 2020. Surface and catalyst
driven singlet oxygen formation in Li-O2 cells. Electrochimica Acta. 362(12),
137175.
mla: Samojlov, Aleksej, et al. “Surface and Catalyst Driven Singlet Oxygen Formation
in Li-O2 Cells.” Electrochimica Acta, vol. 362, no. 12, 137175, Elsevier,
2020, doi:10.1016/j.electacta.2020.137175.
short: A. Samojlov, D. Schuster, J. Kahr, S.A. Freunberger, Electrochimica Acta
362 (2020).
date_created: 2020-04-20T19:29:31Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2023-08-21T06:14:21Z
day: '01'
ddc:
- '540'
department:
- _id: StFr
doi: 10.1016/j.electacta.2020.137175
external_id:
isi:
- '000582869700060'
file:
- access_level: open_access
checksum: 1ab1aa2024d431e2a089ea336bc08298
content_type: application/pdf
creator: dernst
date_created: 2020-10-01T13:20:45Z
date_updated: 2020-10-01T13:20:45Z
file_id: '8593'
file_name: 2020_ElectrochimicaActa_Samojlov.pdf
file_size: 1404030
relation: main_file
success: 1
file_date_updated: 2020-10-01T13:20:45Z
has_accepted_license: '1'
intvolume: ' 362'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
publication: Electrochimica Acta
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Surface and catalyst driven singlet oxygen formation in Li-O2 cells
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 362
year: '2020'
...
---
_id: '7673'
abstract:
- lang: eng
text: Combining drugs can improve the efficacy of treatments. However, predicting
the effect of drug combinations is still challenging. The combined potency of
drugs determines the drug interaction, which is classified as synergistic, additive,
antagonistic, or suppressive. While probabilistic, non-mechanistic models exist,
there is currently no biophysical model that can predict antibiotic interactions.
Here, we present a physiologically relevant model of the combined action of antibiotics
that inhibit protein synthesis by targeting the ribosome. This model captures
the kinetics of antibiotic binding and transport, and uses bacterial growth laws
to predict growth in the presence of antibiotic combinations. We find that this
biophysical model can produce all drug interaction types except suppression. We
show analytically that antibiotics which cannot bind to the ribosome simultaneously
generally act as substitutes for one another, leading to additive drug interactions.
Previously proposed null expectations for higher-order drug interactions follow
as a limiting case of our model. We further extend the model to include the effects
of direct physical or allosteric interactions between individual drugs on the
ribosome. Notably, such direct interactions profoundly change the combined drug
effect, depending on the kinetic parameters of the drugs used. The model makes
additional predictions for the effects of resistance genes on drug interactions
and for interactions between ribosome-targeting antibiotics and antibiotics with
other targets. These findings enhance our understanding of the interplay between
drug action and cell physiology and are a key step toward a general framework
for predicting drug interactions.
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
citation:
ama: Kavcic B, Tkačik G, Bollenbach MT. A minimal biophysical model of combined
antibiotic action. bioRxiv. 2020. doi:10.1101/2020.04.18.047886
apa: Kavcic, B., Tkačik, G., & Bollenbach, M. T. (2020). A minimal biophysical
model of combined antibiotic action. bioRxiv. Cold Spring Harbor Laboratory.
https://doi.org/10.1101/2020.04.18.047886
chicago: Kavcic, Bor, Gašper Tkačik, and Mark Tobias Bollenbach. “A Minimal Biophysical
Model of Combined Antibiotic Action.” BioRxiv. Cold Spring Harbor Laboratory,
2020. https://doi.org/10.1101/2020.04.18.047886.
ieee: B. Kavcic, G. Tkačik, and M. T. Bollenbach, “A minimal biophysical model of
combined antibiotic action,” bioRxiv. Cold Spring Harbor Laboratory, 2020.
ista: Kavcic B, Tkačik G, Bollenbach MT. 2020. A minimal biophysical model of combined
antibiotic action. bioRxiv, 10.1101/2020.04.18.047886.
mla: Kavcic, Bor, et al. “A Minimal Biophysical Model of Combined Antibiotic Action.”
BioRxiv, Cold Spring Harbor Laboratory, 2020, doi:10.1101/2020.04.18.047886.
short: B. Kavcic, G. Tkačik, M.T. Bollenbach, BioRxiv (2020).
date_created: 2020-04-22T08:27:56Z
date_published: 2020-04-18T00:00:00Z
date_updated: 2024-03-25T23:30:05Z
day: '18'
department:
- _id: GaTk
doi: 10.1101/2020.04.18.047886
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://doi.org/10.1101/2020.04.18.047886 '
month: '04'
oa: 1
oa_version: Preprint
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication: bioRxiv
publication_status: published
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '8997'
relation: later_version
status: public
- id: '8657'
relation: dissertation_contains
status: public
status: public
title: A minimal biophysical model of combined antibiotic action
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7675'
abstract:
- lang: eng
text: 'In prokaryotes, thermodynamic models of gene regulation provide a highly
quantitative mapping from promoter sequences to gene expression levels that is
compatible with in vivo and in vitro bio-physical measurements. Such concordance
has not been achieved for models of enhancer function in eukaryotes. In equilibrium
models, it is difficult to reconcile the reported short transcription factor (TF)
residence times on the DNA with the high specificity of regulation. In non-equilibrium
models, progress is difficult due to an explosion in the number of parameters.
Here, we navigate this complexity by looking for minimal non-equilibrium enhancer
models that yield desired regulatory phenotypes: low TF residence time, high specificity
and tunable cooperativity. We find that a single extra parameter, interpretable
as the “linking rate” by which bound TFs interact with Mediator components, enables
our models to escape equilibrium bounds and access optimal regulatory phenotypes,
while remaining consistent with the reported phenomenology and simple enough to
be inferred from upcoming experiments. We further find that high specificity in
non-equilibrium models is in a tradeoff with gene expression noise, predicting
bursty dynamics — an experimentally-observed hallmark of eukaryotic transcription.
By drastically reducing the vast parameter space to a much smaller subspace that
optimally realizes biological function prior to inference from data, our normative
approach holds promise for mathematical models in systems biology.'
article_processing_charge: No
author:
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
- first_name: Benjamin
full_name: Zoller, Benjamin
last_name: Zoller
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
citation:
ama: Grah R, Zoller B, Tkačik G. Normative models of enhancer function. bioRxiv.
2020. doi:10.1101/2020.04.08.029405
apa: Grah, R., Zoller, B., & Tkačik, G. (2020). Normative models of enhancer
function. bioRxiv. Cold Spring Harbor Laboratory. https://doi.org/10.1101/2020.04.08.029405
chicago: Grah, Rok, Benjamin Zoller, and Gašper Tkačik. “Normative Models of Enhancer
Function.” BioRxiv. Cold Spring Harbor Laboratory, 2020. https://doi.org/10.1101/2020.04.08.029405.
ieee: R. Grah, B. Zoller, and G. Tkačik, “Normative models of enhancer function,”
bioRxiv. Cold Spring Harbor Laboratory, 2020.
ista: Grah R, Zoller B, Tkačik G. 2020. Normative models of enhancer function. bioRxiv,
10.1101/2020.04.08.029405.
mla: Grah, Rok, et al. “Normative Models of Enhancer Function.” BioRxiv,
Cold Spring Harbor Laboratory, 2020, doi:10.1101/2020.04.08.029405.
short: R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
date_created: 2020-04-23T10:12:51Z
date_published: 2020-04-09T00:00:00Z
date_updated: 2023-09-07T13:13:26Z
day: '09'
department:
- _id: CaGu
- _id: GaTk
doi: 10.1101/2020.04.08.029405
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'https://doi.org/10.1101/2020.04.08.029405 '
month: '04'
oa: 1
oa_version: Preprint
project:
- _id: 2665AAFE-B435-11E9-9278-68D0E5697425
grant_number: RGP0034/2018
name: Can evolution minimize spurious signaling crosstalk to reach optimal performance?
- _id: 267C84F4-B435-11E9-9278-68D0E5697425
name: Biophysically realistic genotype-phenotype maps for regulatory networks
publication: bioRxiv
publication_status: published
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '8155'
relation: dissertation_contains
status: public
status: public
title: Normative models of enhancer function
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7680'
abstract:
- lang: eng
text: "Proteins and their complex dynamic interactions regulate cellular mechanisms
from sensing and transducing extracellular signals, to mediating genetic responses,
and sustaining or changing cell morphology. To manipulate these protein-protein
interactions (PPIs) that govern the behavior and fate of cells, synthetically
constructed, genetically encoded tools provide the means to precisely target proteins
of interest (POIs), and control their subcellular localization and activity in
vitro and in vivo. Ideal synthetic tools react to an orthogonal cue, i.e. a trigger
that does not activate any other endogenous process, thereby allowing manipulation
of the POI alone.\r\nIn optogenetics, naturally occurring photosensory domain
from plants, algae and bacteria are re-purposed and genetically fused to POIs.
Illumination with light of a specific wavelength triggers a conformational change
that can mediate PPIs, such as dimerization or oligomerization. By using light
as a trigger, these tools can be activated with high spatial and temporal precision,
on subcellular and millisecond scales. Chemogenetic tools consist of protein domains
that recognize and bind small molecules. By genetic fusion to POIs, these domains
can mediate PPIs upon addition of their specific ligands, which are often synthetically
designed to provide highly specific interactions and exhibit good bioavailability.\r\nMost
optogenetic tools to mediate PPIs are based on well-studied photoreceptors responding
to red, blue or near-UV light, leaving a striking gap in the green band of the
visible light spectrum. Among both optogenetic and chemogenetic tools, there is
an abundance of methods to induce PPIs, but tools to disrupt them require UV illumination,
rely on covalent linkage and subsequent enzymatic cleavage or initially result
in protein clustering of unknown stoichiometry.\r\nThis work describes how the
recently structurally and photochemically characterized green-light responsive
cobalamin-binding domains (CBDs) from bacterial transcription factors were re-purposed
to function as a green-light responsive optogenetic tool. In contrast to previously
engineered optogenetic tools, CBDs do not induce PPI, but rather confer a PPI
already upon expression, which can be rapidly disrupted by illumination. This
was employed to mimic inhibition of constitutive activity of a growth factor receptor,
and successfully implement for cell signalling in mammalian cells and in vivo
to rescue development in zebrafish. This work further describes the development
and application of a chemically induced de-dimerizer (CDD) based on a recently
identified and structurally described bacterial oxyreductase. CDD forms a dimer
upon expression in absence of its cofactor, the flavin derivative F420. Safety
and of domain expression and ligand exposure are demonstrated in vitro and in
vivo in zebrafish. The system is further applied to inhibit cell signalling output
from a chimeric receptor upon F420 treatment.\r\nCBDs and CDD expand the repertoire
of synthetic tools by providing novel mechanisms of mediating PPIs, and by recognizing
previously not utilized cues. In the future, they can readily be combined with
existing synthetic tools to functionally manipulate PPIs in vitro and in vivo."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stephanie
full_name: Kainrath, Stephanie
id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
last_name: Kainrath
citation:
ama: Kainrath S. Synthetic tools for optogenetic and chemogenetic inhibition of
cellular signals. 2020. doi:10.15479/AT:ISTA:7680
apa: Kainrath, S. (2020). Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7680
chicago: Kainrath, Stephanie. “Synthetic Tools for Optogenetic and Chemogenetic
Inhibition of Cellular Signals.” Institute of Science and Technology Austria,
2020. https://doi.org/10.15479/AT:ISTA:7680.
ieee: S. Kainrath, “Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals,” Institute of Science and Technology Austria, 2020.
ista: Kainrath S. 2020. Synthetic tools for optogenetic and chemogenetic inhibition
of cellular signals. Institute of Science and Technology Austria.
mla: Kainrath, Stephanie. Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7680.
short: S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition
of Cellular Signals, Institute of Science and Technology Austria, 2020.
date_created: 2020-04-24T16:00:51Z
date_published: 2020-04-24T00:00:00Z
date_updated: 2023-09-22T09:20:10Z
day: '24'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:7680
file:
- access_level: open_access
checksum: fb9a4468eb27be92690728e35c823796
content_type: application/pdf
creator: stgingl
date_created: 2020-04-28T11:19:21Z
date_updated: 2021-10-31T23:30:05Z
embargo: 2021-10-30
file_id: '7692'
file_name: Thesis_without-signatures_PDFA.pdf
file_size: 3268017
relation: main_file
- access_level: closed
checksum: f6c80ca97104a631a328cb79a2c53493
content_type: application/octet-stream
creator: stgingl
date_created: 2020-04-28T11:19:24Z
date_updated: 2021-10-31T23:30:05Z
embargo_to: open_access
file_id: '7693'
file_name: Thesis_without signatures.docx
file_size: 5167703
relation: source_file
file_date_updated: 2021-10-31T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: None
page: '98'
publication_identifier:
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1028'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
title: Synthetic tools for optogenetic and chemogenetic inhibition of cellular signals
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7683'
abstract:
- lang: eng
text: For any free oriented Borel–Moore homology theory A, we construct an associative
product on the A-theory of the stack of Higgs torsion sheaves over a projective
curve C. We show that the resulting algebra AHa0C admits a natural shuffle presentation,
and prove it is faithful when A is replaced with usual Borel–Moore homology groups.
We also introduce moduli spaces of stable triples, heavily inspired by Nakajima
quiver varieties, whose A-theory admits an AHa0C-action. These triples can be
interpreted as certain sheaves on PC(ωC⊕OC). In particular, we obtain an action
of AHa0C on the cohomology of Hilbert schemes of points on T∗C.
article_number: '30'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Sasha
full_name: Minets, Sasha
id: 3E7C5304-F248-11E8-B48F-1D18A9856A87
last_name: Minets
orcid: 0000-0003-3883-1806
citation:
ama: Minets S. Cohomological Hall algebras for Higgs torsion sheaves, moduli of
triples and sheaves on surfaces. Selecta Mathematica, New Series. 2020;26(2).
doi:10.1007/s00029-020-00553-x
apa: Minets, S. (2020). Cohomological Hall algebras for Higgs torsion sheaves, moduli
of triples and sheaves on surfaces. Selecta Mathematica, New Series. Springer
Nature. https://doi.org/10.1007/s00029-020-00553-x
chicago: Minets, Sasha. “Cohomological Hall Algebras for Higgs Torsion Sheaves,
Moduli of Triples and Sheaves on Surfaces.” Selecta Mathematica, New Series.
Springer Nature, 2020. https://doi.org/10.1007/s00029-020-00553-x.
ieee: S. Minets, “Cohomological Hall algebras for Higgs torsion sheaves, moduli
of triples and sheaves on surfaces,” Selecta Mathematica, New Series, vol.
26, no. 2. Springer Nature, 2020.
ista: Minets S. 2020. Cohomological Hall algebras for Higgs torsion sheaves, moduli
of triples and sheaves on surfaces. Selecta Mathematica, New Series. 26(2), 30.
mla: Minets, Sasha. “Cohomological Hall Algebras for Higgs Torsion Sheaves, Moduli
of Triples and Sheaves on Surfaces.” Selecta Mathematica, New Series, vol.
26, no. 2, 30, Springer Nature, 2020, doi:10.1007/s00029-020-00553-x.
short: S. Minets, Selecta Mathematica, New Series 26 (2020).
date_created: 2020-04-26T22:00:44Z
date_published: 2020-04-15T00:00:00Z
date_updated: 2023-08-21T06:14:58Z
day: '15'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1007/s00029-020-00553-x
external_id:
arxiv:
- '1801.01429'
isi:
- '000526036400001'
file:
- access_level: open_access
checksum: 2368c4662629b4759295eb365323b2ad
content_type: application/pdf
creator: dernst
date_created: 2020-04-28T10:57:58Z
date_updated: 2020-07-14T12:48:02Z
file_id: '7690'
file_name: 2020_SelectaMathematica_Minets.pdf
file_size: 792469
relation: main_file
file_date_updated: 2020-07-14T12:48:02Z
has_accepted_license: '1'
intvolume: ' 26'
isi: 1
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Selecta Mathematica, New Series
publication_identifier:
eissn:
- '14209020'
issn:
- '10221824'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cohomological Hall algebras for Higgs torsion sheaves, moduli of triples and
sheaves on surfaces
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 26
year: '2020'
...
---
_id: '7684'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption
of hippocampal replay leads to selective memory deficit. Neuron. 2020;106(2):291-300.e6.
doi:10.1016/j.neuron.2020.01.021
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Assembly-specific disruption of hippocampal replay leads to selective memory deficit.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.021
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory
Deficit.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.021.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific
disruption of hippocampal replay leads to selective memory deficit,” Neuron,
vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific
disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2),
291–300.e6.
mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay
Leads to Selective Memory Deficit.” Neuron, vol. 106, no. 2, Elsevier,
2020, p. 291–300.e6, doi:10.1016/j.neuron.2020.01.021.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020)
291–300.e6.
date_created: 2020-04-26T22:00:45Z
date_published: 2020-04-22T00:00:00Z
date_updated: 2023-08-21T06:15:31Z
day: '22'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.021
ec_funded: 1
external_id:
isi:
- '000528268200013'
pmid:
- '32070475'
intvolume: ' 106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.021
month: '04'
oa: 1
oa_version: Published Version
page: 291-300.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
eissn:
- '10974199'
issn:
- '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/librarian-of-memory/
scopus_import: '1'
status: public
title: Assembly-specific disruption of hippocampal replay leads to selective memory
deficit
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '7686'
abstract:
- lang: eng
text: 'The agricultural green revolution spectacularly enhanced crop yield and lodging
resistance with modified DELLA-mediated gibberellin signaling. However, this was
achieved at the expense of reduced nitrogen-use efficiency (NUE). Recently, Wu
et al. revealed novel gibberellin signaling that provides a blueprint for improving
tillering and NUE in Green Revolution varieties (GRVs). '
article_processing_charge: No
article_type: original
author:
- first_name: Huidan
full_name: Xue, Huidan
last_name: Xue
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Guanghui
full_name: Xiao, Guanghui
last_name: Xiao
citation:
ama: 'Xue H, Zhang Y, Xiao G. Neo-gibberellin signaling: Guiding the next generation
of the green revolution. Trends in Plant Science. 2020;25(6):520-522. doi:10.1016/j.tplants.2020.04.001'
apa: 'Xue, H., Zhang, Y., & Xiao, G. (2020). Neo-gibberellin signaling: Guiding
the next generation of the green revolution. Trends in Plant Science. Elsevier.
https://doi.org/10.1016/j.tplants.2020.04.001'
chicago: 'Xue, Huidan, Yuzhou Zhang, and Guanghui Xiao. “Neo-Gibberellin Signaling:
Guiding the next Generation of the Green Revolution.” Trends in Plant Science.
Elsevier, 2020. https://doi.org/10.1016/j.tplants.2020.04.001.'
ieee: 'H. Xue, Y. Zhang, and G. Xiao, “Neo-gibberellin signaling: Guiding the next
generation of the green revolution,” Trends in Plant Science, vol. 25,
no. 6. Elsevier, pp. 520–522, 2020.'
ista: 'Xue H, Zhang Y, Xiao G. 2020. Neo-gibberellin signaling: Guiding the next
generation of the green revolution. Trends in Plant Science. 25(6), 520–522.'
mla: 'Xue, Huidan, et al. “Neo-Gibberellin Signaling: Guiding the next Generation
of the Green Revolution.” Trends in Plant Science, vol. 25, no. 6, Elsevier,
2020, pp. 520–22, doi:10.1016/j.tplants.2020.04.001.'
short: H. Xue, Y. Zhang, G. Xiao, Trends in Plant Science 25 (2020) 520–522.
date_created: 2020-04-26T22:00:46Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2023-08-21T06:16:01Z
day: '01'
department:
- _id: JiFr
doi: 10.1016/j.tplants.2020.04.001
external_id:
isi:
- '000533518400003'
pmid:
- '32407691'
intvolume: ' 25'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 520-522
pmid: 1
publication: Trends in Plant Science
publication_identifier:
issn:
- 1360-1385
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Neo-gibberellin signaling: Guiding the next generation of the green revolution'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 25
year: '2020'
...
---
_id: '7687'
abstract:
- lang: eng
text: A working group, which was established within the Network of Repository Managers (RepManNet), has dealt with common certifications for repositories. In
addition, current requirements of the research funding agencies FWF and EU were
also taken into account. The Core Trust Seal was examined in more detail. For
this purpose, a questionnaire was sent to those organizations that are already certified
with CTS in Austria. The answers were summarized and evaluated anonymously. It
is recommended to go for a repository certification. Moreover, the development
of a DINI certificate in Austria is strongly suggested.
- lang: ger
text: ' Eine Arbeitsgruppe, die im Rahmen des Netzwerks für RepositorienmanagerInnen
(RepManNet) entstanden ist, hat sich mit gängigen Zertifizierungen für Repositorien
beschäftigt. Weiters wurden aktuelle Vorgaben der Forschungsförderer FWF und EU
herangezogen. Das Core Trust Seal wurde genauer betrachtet. Hierfür wurden jenen Organisationen, die in Österreich bereits mit CTS zertifiziert
sind, ein Fragebogen übermittelt. Die Antworten wurden anonymisiert zusammengefasst
und ausgewertet. Plädiert wird für eine Zertifizierung von Repositorien und die
Entwicklung einer DINI-Zertifizierung in Österreich.'
article_processing_charge: No
article_type: original
author:
- first_name: Doris
full_name: Ernst, Doris
id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
last_name: Ernst
orcid: 0000-0002-2354-0195
- first_name: Gertraud
full_name: Novotny, Gertraud
last_name: Novotny
- first_name: Eva Maria
full_name: Schönher, Eva Maria
last_name: Schönher
citation:
ama: Ernst D, Novotny G, Schönher EM. (Core Trust) Seal your repository! Mitteilungen
der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. 2020;73(1):46-59.
doi:10.31263/voebm.v73i1.3491
apa: Ernst, D., Novotny, G., & Schönher, E. M. (2020). (Core Trust) Seal your
repository! Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen
und Bibliothekare. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare.
https://doi.org/10.31263/voebm.v73i1.3491
chicago: Ernst, Doris, Gertraud Novotny, and Eva Maria Schönher. “(Core Trust) Seal
your repository!” Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen
und Bibliothekare. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare,
2020. https://doi.org/10.31263/voebm.v73i1.3491.
ieee: D. Ernst, G. Novotny, and E. M. Schönher, “(Core Trust) Seal your repository!,”
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare,
vol. 73, no. 1. Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare,
pp. 46–59, 2020.
ista: Ernst D, Novotny G, Schönher EM. 2020. (Core Trust) Seal your repository!
Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare.
73(1), 46–59.
mla: Ernst, Doris, et al. “(Core Trust) Seal your repository!” Mitteilungen der
Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, vol. 73,
no. 1, Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare, 2020,
pp. 46–59, doi:10.31263/voebm.v73i1.3491.
short: D. Ernst, G. Novotny, E.M. Schönher, Mitteilungen der Vereinigung Österreichischer
Bibliothekarinnen und Bibliothekare 73 (2020) 46–59.
date_created: 2020-04-28T08:37:38Z
date_published: 2020-04-28T00:00:00Z
date_updated: 2024-02-27T13:41:03Z
day: '28'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.31263/voebm.v73i1.3491
file:
- access_level: open_access
checksum: fee784f15a489deb7def6ccf8c5bf8c3
content_type: application/pdf
creator: dernst
date_created: 2020-06-17T10:50:13Z
date_updated: 2023-04-03T09:17:25Z
file_id: '7970'
file_name: 2020_VOEB_Ernst.pdf
file_size: 579291
relation: main_file
file_date_updated: 2023-04-03T09:17:25Z
has_accepted_license: '1'
intvolume: ' 73'
issue: '1'
language:
- iso: ger
month: '04'
oa: 1
oa_version: Published Version
page: 46-59
popular_science: '1'
publication: Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare
publication_identifier:
issn:
- 1022-2588
publication_status: published
publisher: Vereinigung Osterreichischer Bibliothekarinnen und Bibliothekare
scopus_import: '1'
status: public
title: (Core Trust) Seal your repository!
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 73
year: '2020'
...
---
_id: '7689'
abstract:
- lang: eng
text: "These are the supplementary research data to the publication \"Zero field
splitting of heavy-hole states in quantum dots\". All matrix files have the same
format. Within each column the bias voltage is changed. Each column corresponds
to either a different gate voltage or magnetic field. The voltage values are given
in mV, the current values in pA. Find a specific description in the included Readme
file.\r\n"
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Katsaros G. Supplementary data for “Zero field splitting of heavy-hole states
in quantum dots.” 2020. doi:10.15479/AT:ISTA:7689
apa: Katsaros, G. (2020). Supplementary data for “Zero field splitting of heavy-hole
states in quantum dots.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7689
chicago: Katsaros, Georgios. “Supplementary Data for ‘Zero Field Splitting of Heavy-Hole
States in Quantum Dots.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7689.
ieee: G. Katsaros, “Supplementary data for ‘Zero field splitting of heavy-hole states
in quantum dots.’” Institute of Science and Technology Austria, 2020.
ista: Katsaros G. 2020. Supplementary data for ‘Zero field splitting of heavy-hole
states in quantum dots’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:7689.
mla: Katsaros, Georgios. Supplementary Data for “Zero Field Splitting of Heavy-Hole
States in Quantum Dots.” Institute of Science and Technology Austria, 2020,
doi:10.15479/AT:ISTA:7689.
short: G. Katsaros, (2020).
contributor:
- contributor_type: contact_person
first_name: Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
date_created: 2020-05-01T15:14:46Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2024-02-21T12:44:02Z
day: '01'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:7689
ec_funded: 1
file:
- access_level: open_access
checksum: d23c0cb9e2d19e14e2f902b88b97c05d
content_type: application/x-zip-compressed
creator: gkatsaro
date_created: 2020-05-01T15:13:28Z
date_updated: 2020-07-14T12:48:02Z
file_id: '7786'
file_name: DOI_ZeroFieldSplitting.zip
file_size: 5514403
relation: main_file
file_date_updated: 2020-07-14T12:48:02Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
- _id: 237B3DA4-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: P32235
name: Towards scalable hut wire quantum devices
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8203'
relation: used_in_publication
status: public
status: public
title: Supplementary data for "Zero field splitting of heavy-hole states in quantum
dots"
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7695'
abstract:
- lang: eng
text: The TPLATE complex (TPC) is a key endocytic adaptor protein complex in plants.
TPC in Arabidopsis (Arabidopsis thaliana) contains six evolutionarily conserved
subunits and two plant-specific subunits, AtEH1/Pan1 and AtEH2/Pan1, although
cytoplasmic proteins are not associated with the hexameric subcomplex in the cytoplasm.
To investigate the dynamic assembly of the octameric TPC at the plasma membrane
(PM), we performed state-of-the-art dual-color live cell imaging at physiological
and lowered temperatures. Lowering the temperature slowed down endocytosis, thereby
enhancing the temporal resolution of the differential recruitment of endocytic
components. Under both normal and lowered temperature conditions, the core TPC
subunit TPLATE and the AtEH/Pan1 proteins exhibited simultaneous recruitment at
the PM. These results, together with co-localization analysis of different TPC
subunits, allow us to conclude that TPC in plant cells is not recruited to the
PM sequentially but as an octameric complex.
article_processing_charge: No
article_type: original
author:
- first_name: J
full_name: Wang, J
last_name: Wang
- first_name: E
full_name: Mylle, E
last_name: Mylle
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: N
full_name: Besbrugge, N
last_name: Besbrugge
- first_name: G
full_name: De Jaeger, G
last_name: De Jaeger
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: R
full_name: Pleskot, R
last_name: Pleskot
- first_name: D
full_name: van Damme, D
last_name: van Damme
citation:
ama: Wang J, Mylle E, Johnson AJ, et al. High temporal resolution reveals simultaneous
plasma membrane recruitment of TPLATE complex subunits. Plant Physiology.
2020;183(3):986-997. doi:10.1104/pp.20.00178
apa: Wang, J., Mylle, E., Johnson, A. J., Besbrugge, N., De Jaeger, G., Friml, J.,
… van Damme, D. (2020). High temporal resolution reveals simultaneous plasma membrane
recruitment of TPLATE complex subunits. Plant Physiology. American Society
of Plant Biologists. https://doi.org/10.1104/pp.20.00178
chicago: Wang, J, E Mylle, Alexander J Johnson, N Besbrugge, G De Jaeger, Jiří Friml,
R Pleskot, and D van Damme. “High Temporal Resolution Reveals Simultaneous Plasma
Membrane Recruitment of TPLATE Complex Subunits.” Plant Physiology. American
Society of Plant Biologists, 2020. https://doi.org/10.1104/pp.20.00178.
ieee: J. Wang et al., “High temporal resolution reveals simultaneous plasma
membrane recruitment of TPLATE complex subunits,” Plant Physiology, vol.
183, no. 3. American Society of Plant Biologists, pp. 986–997, 2020.
ista: Wang J, Mylle E, Johnson AJ, Besbrugge N, De Jaeger G, Friml J, Pleskot R,
van Damme D. 2020. High temporal resolution reveals simultaneous plasma membrane
recruitment of TPLATE complex subunits. Plant Physiology. 183(3), 986–997.
mla: Wang, J., et al. “High Temporal Resolution Reveals Simultaneous Plasma Membrane
Recruitment of TPLATE Complex Subunits.” Plant Physiology, vol. 183, no.
3, American Society of Plant Biologists, 2020, pp. 986–97, doi:10.1104/pp.20.00178.
short: J. Wang, E. Mylle, A.J. Johnson, N. Besbrugge, G. De Jaeger, J. Friml, R.
Pleskot, D. van Damme, Plant Physiology 183 (2020) 986–997.
date_created: 2020-04-29T15:23:00Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-09-05T12:20:02Z
day: '01'
department:
- _id: JiFr
doi: 10.1104/pp.20.00178
external_id:
isi:
- '000550682000018'
pmid:
- '32321842'
intvolume: ' 183'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.02.13.948109
month: '07'
oa: 1
oa_version: Preprint
page: 986-997
pmid: 1
project:
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: Plant Physiology
publication_identifier:
eissn:
- 1532-2548
issn:
- 0032-0889
publication_status: published
publisher: American Society of Plant Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: High temporal resolution reveals simultaneous plasma membrane recruitment of
TPLATE complex subunits
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 183
year: '2020'
...
---
_id: '7697'
abstract:
- lang: eng
text: "* Morphogenesis and adaptive tropic growth in plants depend on gradients
of the phytohormone auxin, mediated by the membrane‐based PIN‐FORMED (PIN) auxin
transporters. PINs localize to a particular side of the plasma membrane (PM) or
to the endoplasmic reticulum (ER) to directionally transport auxin and maintain
intercellular and intracellular auxin homeostasis, respectively. However, the
molecular cues that confer their diverse cellular localizations remain largely
unknown.\r\n* In this study, we systematically swapped the domains between ER‐
and PM‐localized PIN proteins, as well as between apical and basal PM‐localized
PINs from Arabidopsis thaliana , to shed light on why PIN family members with
similar topological structures reside at different membrane compartments within
cells.\r\n* Our results show that not only do the N‐ and C‐terminal transmembrane
domains (TMDs) and central hydrophilic loop contribute to their differential subcellular
localizations and cellular polarity, but that the pairwise‐matched N‐ and C‐terminal
TMDs resulting from intramolecular domain–domain coevolution are also crucial
for their divergent patterns of localization.\r\n* These findings illustrate the
complexity of the evolutionary path of PIN proteins in acquiring their plethora
of developmental functions and adaptive growth in plants."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: Corinna
full_name: Hartinger, Corinna
id: AEFB2266-8ABF-11EA-AA39-812C3623CBE4
last_name: Hartinger
orcid: 0000-0003-1618-2737
- first_name: Xiaojuan
full_name: Wang, Xiaojuan
last_name: Wang
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Zhang Y, Hartinger C, Wang X, Friml J. Directional auxin fluxes in plants by
intramolecular domain‐domain co‐evolution of PIN auxin transporters. New Phytologist.
2020;227(5):1406-1416. doi:10.1111/nph.16629
apa: Zhang, Y., Hartinger, C., Wang, X., & Friml, J. (2020). Directional auxin
fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters.
New Phytologist. Wiley. https://doi.org/10.1111/nph.16629
chicago: Zhang, Yuzhou, Corinna Hartinger, Xiaojuan Wang, and Jiří Friml. “Directional
Auxin Fluxes in Plants by Intramolecular Domain‐domain Co‐evolution of PIN Auxin
Transporters.” New Phytologist. Wiley, 2020. https://doi.org/10.1111/nph.16629.
ieee: Y. Zhang, C. Hartinger, X. Wang, and J. Friml, “Directional auxin fluxes in
plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters,”
New Phytologist, vol. 227, no. 5. Wiley, pp. 1406–1416, 2020.
ista: Zhang Y, Hartinger C, Wang X, Friml J. 2020. Directional auxin fluxes in plants
by intramolecular domain‐domain co‐evolution of PIN auxin transporters. New Phytologist.
227(5), 1406–1416.
mla: Zhang, Yuzhou, et al. “Directional Auxin Fluxes in Plants by Intramolecular
Domain‐domain Co‐evolution of PIN Auxin Transporters.” New Phytologist,
vol. 227, no. 5, Wiley, 2020, pp. 1406–16, doi:10.1111/nph.16629.
short: Y. Zhang, C. Hartinger, X. Wang, J. Friml, New Phytologist 227 (2020) 1406–1416.
date_created: 2020-04-30T08:43:29Z
date_published: 2020-09-01T00:00:00Z
date_updated: 2023-09-05T15:46:04Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.16629
ec_funded: 1
external_id:
isi:
- '000534092400001'
pmid:
- '32350870'
file:
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checksum: 8e8150dbbba8cb65b72f81d1f0864b8b
content_type: application/pdf
creator: dernst
date_created: 2020-11-24T12:19:38Z
date_updated: 2020-11-24T12:19:38Z
file_id: '8799'
file_name: 2020_09_NewPhytologist_Zhang.pdf
file_size: 3643395
relation: main_file
success: 1
file_date_updated: 2020-11-24T12:19:38Z
has_accepted_license: '1'
intvolume: ' 227'
isi: 1
issue: '5'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 1406-1416
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution
of PIN auxin transporters
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 227
year: '2020'
...
---
_id: '7707'
abstract:
- lang: eng
text: The growing sample size of genome-wide association studies has facilitated
the discovery of gene-environment interactions (GxE). Here we propose a maximum
likelihood method to estimate the contribution of GxE to continuous traits taking
into account all interacting environmental variables, without the need to measure
any. Extensive simulations demonstrate that our method provides unbiased interaction
estimates and excellent coverage. We also offer strategies to distinguish specific
GxE from general scale effects. Applying our method to 32 traits in the UK Biobank
reveals that while the genetic risk score (GRS) of 376 variants explains 5.2%
of body mass index (BMI) variance, GRSxE explains an additional 1.9%. Nevertheless,
this interaction holds for any variable with identical correlation to BMI as the
GRS, hence may not be GRS-specific. Still, we observe that the global contribution
of specific GRSxE to complex traits is substantial for nine obesity-related measures
(including leg impedance and trunk fat-free mass).
article_number: '1385'
article_processing_charge: No
article_type: original
author:
- first_name: Jonathan
full_name: Sulc, Jonathan
last_name: Sulc
- first_name: Ninon
full_name: Mounier, Ninon
last_name: Mounier
- first_name: Felix
full_name: Günther, Felix
last_name: Günther
- first_name: Thomas
full_name: Winkler, Thomas
last_name: Winkler
- first_name: Andrew R.
full_name: Wood, Andrew R.
last_name: Wood
- first_name: Timothy M.
full_name: Frayling, Timothy M.
last_name: Frayling
- first_name: Iris M.
full_name: Heid, Iris M.
last_name: Heid
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Zoltán
full_name: Kutalik, Zoltán
last_name: Kutalik
citation:
ama: Sulc J, Mounier N, Günther F, et al. Quantification of the overall contribution
of gene-environment interaction for obesity-related traits. Nature Communications.
2020;11. doi:10.1038/s41467-020-15107-0
apa: Sulc, J., Mounier, N., Günther, F., Winkler, T., Wood, A. R., Frayling, T.
M., … Kutalik, Z. (2020). Quantification of the overall contribution of gene-environment
interaction for obesity-related traits. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-020-15107-0
chicago: Sulc, Jonathan, Ninon Mounier, Felix Günther, Thomas Winkler, Andrew R.
Wood, Timothy M. Frayling, Iris M. Heid, Matthew Richard Robinson, and Zoltán
Kutalik. “Quantification of the Overall Contribution of Gene-Environment Interaction
for Obesity-Related Traits.” Nature Communications. Springer Nature, 2020.
https://doi.org/10.1038/s41467-020-15107-0.
ieee: J. Sulc et al., “Quantification of the overall contribution of gene-environment
interaction for obesity-related traits,” Nature Communications, vol. 11.
Springer Nature, 2020.
ista: Sulc J, Mounier N, Günther F, Winkler T, Wood AR, Frayling TM, Heid IM, Robinson
MR, Kutalik Z. 2020. Quantification of the overall contribution of gene-environment
interaction for obesity-related traits. Nature Communications. 11, 1385.
mla: Sulc, Jonathan, et al. “Quantification of the Overall Contribution of Gene-Environment
Interaction for Obesity-Related Traits.” Nature Communications, vol. 11,
1385, Springer Nature, 2020, doi:10.1038/s41467-020-15107-0.
short: J. Sulc, N. Mounier, F. Günther, T. Winkler, A.R. Wood, T.M. Frayling, I.M.
Heid, M.R. Robinson, Z. Kutalik, Nature Communications 11 (2020).
date_created: 2020-04-30T10:39:33Z
date_published: 2020-03-20T00:00:00Z
date_updated: 2021-01-12T08:14:59Z
day: '20'
doi: 10.1038/s41467-020-15107-0
extern: '1'
intvolume: ' 11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-020-15107-0
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Quantification of the overall contribution of gene-environment interaction
for obesity-related traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2020'
...
---
_id: '7708'
abstract:
- lang: eng
text: We conducted DNA methylation association analyses using Illumina 450K data
from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control
cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented
in the OSCA software. We found a significantly higher proportion of neutrophils
in cases compared to controls which replicated in an independent cohort from the
Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model
has been shown in simulations to best account for confounders. When combined in
a methylation profile score, the 25 most-associated probes identified by MOMENT
significantly classified case–control status in the Netherlands sample (area under
the curve, AUC = 0.65, CI95% = [0.62–0.68], p = 8.3 × 10−22). The maximum AUC
achieved was 0.69 (CI95% = [0.66–0.71], p = 4.3 × 10−34) when cell-type proportion
was included in the predictor.
article_number: '10'
article_processing_charge: No
article_type: original
author:
- first_name: Marta F.
full_name: Nabais, Marta F.
last_name: Nabais
- first_name: Tian
full_name: Lin, Tian
last_name: Lin
- first_name: Beben
full_name: Benyamin, Beben
last_name: Benyamin
- first_name: Kelly L.
full_name: Williams, Kelly L.
last_name: Williams
- first_name: Fleur C.
full_name: Garton, Fleur C.
last_name: Garton
- first_name: Anna A. E.
full_name: Vinkhuyzen, Anna A. E.
last_name: Vinkhuyzen
- first_name: Futao
full_name: Zhang, Futao
last_name: Zhang
- first_name: Costanza L.
full_name: Vallerga, Costanza L.
last_name: Vallerga
- first_name: Restuadi
full_name: Restuadi, Restuadi
last_name: Restuadi
- first_name: Anna
full_name: Freydenzon, Anna
last_name: Freydenzon
- first_name: Ramona A. J.
full_name: Zwamborn, Ramona A. J.
last_name: Zwamborn
- first_name: Paul J.
full_name: Hop, Paul J.
last_name: Hop
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Jacob
full_name: Gratten, Jacob
last_name: Gratten
- first_name: Peter M.
full_name: Visscher, Peter M.
last_name: Visscher
- first_name: Eilis
full_name: Hannon, Eilis
last_name: Hannon
- first_name: Jonathan
full_name: Mill, Jonathan
last_name: Mill
- first_name: Matthew A.
full_name: Brown, Matthew A.
last_name: Brown
- first_name: Nigel G.
full_name: Laing, Nigel G.
last_name: Laing
- first_name: Karen A.
full_name: Mather, Karen A.
last_name: Mather
- first_name: Perminder S.
full_name: Sachdev, Perminder S.
last_name: Sachdev
- first_name: Shyuan T.
full_name: Ngo, Shyuan T.
last_name: Ngo
- first_name: Frederik J.
full_name: Steyn, Frederik J.
last_name: Steyn
- first_name: Leanne
full_name: Wallace, Leanne
last_name: Wallace
- first_name: Anjali K.
full_name: Henders, Anjali K.
last_name: Henders
- first_name: Merrilee
full_name: Needham, Merrilee
last_name: Needham
- first_name: Jan H.
full_name: Veldink, Jan H.
last_name: Veldink
- first_name: Susan
full_name: Mathers, Susan
last_name: Mathers
- first_name: Garth
full_name: Nicholson, Garth
last_name: Nicholson
- first_name: Dominic B.
full_name: Rowe, Dominic B.
last_name: Rowe
- first_name: Robert D.
full_name: Henderson, Robert D.
last_name: Henderson
- first_name: Pamela A.
full_name: McCombe, Pamela A.
last_name: McCombe
- first_name: Roger
full_name: Pamphlett, Roger
last_name: Pamphlett
- first_name: Jian
full_name: Yang, Jian
last_name: Yang
- first_name: Ian P.
full_name: Blair, Ian P.
last_name: Blair
- first_name: Allan F.
full_name: McRae, Allan F.
last_name: McRae
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
citation:
ama: Nabais MF, Lin T, Benyamin B, et al. Significant out-of-sample classification
from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic
Medicine. 2020;5. doi:10.1038/s41525-020-0118-3
apa: Nabais, M. F., Lin, T., Benyamin, B., Williams, K. L., Garton, F. C., Vinkhuyzen,
A. A. E., … Wray, N. R. (2020). Significant out-of-sample classification from
methylation profile scoring for amyotrophic lateral sclerosis. Npj Genomic
Medicine. Springer Nature. https://doi.org/10.1038/s41525-020-0118-3
chicago: Nabais, Marta F., Tian Lin, Beben Benyamin, Kelly L. Williams, Fleur C.
Garton, Anna A. E. Vinkhuyzen, Futao Zhang, et al. “Significant Out-of-Sample
Classification from Methylation Profile Scoring for Amyotrophic Lateral Sclerosis.”
Npj Genomic Medicine. Springer Nature, 2020. https://doi.org/10.1038/s41525-020-0118-3.
ieee: M. F. Nabais et al., “Significant out-of-sample classification from
methylation profile scoring for amyotrophic lateral sclerosis,” npj Genomic
Medicine, vol. 5. Springer Nature, 2020.
ista: Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang
F, Vallerga CL, Restuadi R, Freydenzon A, Zwamborn RAJ, Hop PJ, Robinson MR, Gratten
J, Visscher PM, Hannon E, Mill J, Brown MA, Laing NG, Mather KA, Sachdev PS, Ngo
ST, Steyn FJ, Wallace L, Henders AK, Needham M, Veldink JH, Mathers S, Nicholson
G, Rowe DB, Henderson RD, McCombe PA, Pamphlett R, Yang J, Blair IP, McRae AF,
Wray NR. 2020. Significant out-of-sample classification from methylation profile
scoring for amyotrophic lateral sclerosis. npj Genomic Medicine. 5, 10.
mla: Nabais, Marta F., et al. “Significant Out-of-Sample Classification from Methylation
Profile Scoring for Amyotrophic Lateral Sclerosis.” Npj Genomic Medicine,
vol. 5, 10, Springer Nature, 2020, doi:10.1038/s41525-020-0118-3.
short: M.F. Nabais, T. Lin, B. Benyamin, K.L. Williams, F.C. Garton, A.A.E. Vinkhuyzen,
F. Zhang, C.L. Vallerga, R. Restuadi, A. Freydenzon, R.A.J. Zwamborn, P.J. Hop,
M.R. Robinson, J. Gratten, P.M. Visscher, E. Hannon, J. Mill, M.A. Brown, N.G.
Laing, K.A. Mather, P.S. Sachdev, S.T. Ngo, F.J. Steyn, L. Wallace, A.K. Henders,
M. Needham, J.H. Veldink, S. Mathers, G. Nicholson, D.B. Rowe, R.D. Henderson,
P.A. McCombe, R. Pamphlett, J. Yang, I.P. Blair, A.F. McRae, N.R. Wray, Npj Genomic
Medicine 5 (2020).
date_created: 2020-04-30T10:39:54Z
date_published: 2020-02-27T00:00:00Z
date_updated: 2021-01-12T08:14:59Z
day: '27'
doi: 10.1038/s41525-020-0118-3
extern: '1'
intvolume: ' 5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41525-020-0118-3
month: '02'
oa: 1
oa_version: Published Version
publication: npj Genomic Medicine
publication_identifier:
issn:
- 2056-7944
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Significant out-of-sample classification from methylation profile scoring for
amyotrophic lateral sclerosis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2020'
...
---
_id: '5681'
abstract:
- lang: eng
text: 'We introduce dynamically warping grids for adaptive liquid simulation. Our
primary contributions are a strategy for dynamically deforming regular grids over
the course of a simulation and a method for efficiently utilizing these deforming
grids for liquid simulation. Prior work has shown that unstructured grids are
very effective for adaptive fluid simulations. However, unstructured grids often
lead to complicated implementations and a poor cache hit rate due to inconsistent
memory access. Regular grids, on the other hand, provide a fast, fixed memory
access pattern and straightforward implementation. Our method combines the advantages
of both: we leverage the simplicity of regular grids while still achieving practical
and controllable spatial adaptivity. We demonstrate that our method enables adaptive
simulations that are fast, flexible, and robust to null-space issues. At the same
time, our method is simple to implement and takes advantage of existing highly-tuned
algorithms.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: This work was partially supported by JSPS Grant-in-Aid forYoung Scientists
(Start-up) 16H07410, the ERC StartingGrantsrealFlow(StG-2015-637014) andBigSplash(StG-2014-638176).
This research was supported by the Scientific Ser-vice Units (SSU) of IST Austria
through resources providedby Scientific Computing. We would like to express my grati-tude
to Nobuyuki Umetani and Tomas Skrivan for insight-ful discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Ibayashi
full_name: Hikaru, Ibayashi
last_name: Hikaru
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
- first_name: Nils
full_name: Thuerey, Nils
last_name: Thuerey
- first_name: Takeo
full_name: Igarashi, Takeo
last_name: Igarashi
- first_name: Ryoichi
full_name: Ando, Ryoichi
last_name: Ando
citation:
ama: Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. Simulating liquids on dynamically
warping grids. IEEE Transactions on Visualization and Computer Graphics.
2020;26(6):2288-2302. doi:10.1109/TVCG.2018.2883628
apa: Hikaru, I., Wojtan, C., Thuerey, N., Igarashi, T., & Ando, R. (2020). Simulating
liquids on dynamically warping grids. IEEE Transactions on Visualization and
Computer Graphics. IEEE. https://doi.org/10.1109/TVCG.2018.2883628
chicago: Hikaru, Ibayashi, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi
Ando. “Simulating Liquids on Dynamically Warping Grids.” IEEE Transactions
on Visualization and Computer Graphics. IEEE, 2020. https://doi.org/10.1109/TVCG.2018.2883628.
ieee: I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Simulating liquids
on dynamically warping grids,” IEEE Transactions on Visualization and Computer
Graphics, vol. 26, no. 6. IEEE, pp. 2288–2302, 2020.
ista: Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. 2020. Simulating liquids
on dynamically warping grids. IEEE Transactions on Visualization and Computer
Graphics. 26(6), 2288–2302.
mla: Hikaru, Ibayashi, et al. “Simulating Liquids on Dynamically Warping Grids.”
IEEE Transactions on Visualization and Computer Graphics, vol. 26, no.
6, IEEE, 2020, pp. 2288–302, doi:10.1109/TVCG.2018.2883628.
short: I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, IEEE Transactions
on Visualization and Computer Graphics 26 (2020) 2288–2302.
date_created: 2018-12-16T22:59:21Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2023-09-18T09:30:01Z
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ddc:
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department:
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doi: 10.1109/TVCG.2018.2883628
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creator: wojtan
date_created: 2020-10-08T08:34:53Z
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file_id: '8626'
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month: '06'
oa: 1
oa_version: Submitted Version
page: 2288-2302
pmid: 1
publication: IEEE Transactions on Visualization and Computer Graphics
publication_identifier:
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publication_status: published
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quality_controlled: '1'
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title: Simulating liquids on dynamically warping grids
type: journal_article
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year: '2020'
...
---
_id: '6184'
abstract:
- lang: eng
text: We prove edge universality for a general class of correlated real symmetric
or complex Hermitian Wigner matrices with arbitrary expectation. Our theorem also
applies to internal edges of the self-consistent density of states. In particular,
we establish a strong form of band rigidity which excludes mismatches between
location and label of eigenvalues close to internal edges in these general models.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Johannes
full_name: Alt, Johannes
id: 36D3D8B6-F248-11E8-B48F-1D18A9856A87
last_name: Alt
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Torben H
full_name: Krüger, Torben H
id: 3020C786-F248-11E8-B48F-1D18A9856A87
last_name: Krüger
orcid: 0000-0002-4821-3297
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: 'Alt J, Erdös L, Krüger TH, Schröder DJ. Correlated random matrices: Band rigidity
and edge universality. Annals of Probability. 2020;48(2):963-1001. doi:10.1214/19-AOP1379'
apa: 'Alt, J., Erdös, L., Krüger, T. H., & Schröder, D. J. (2020). Correlated
random matrices: Band rigidity and edge universality. Annals of Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/19-AOP1379'
chicago: 'Alt, Johannes, László Erdös, Torben H Krüger, and Dominik J Schröder.
“Correlated Random Matrices: Band Rigidity and Edge Universality.” Annals of
Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/19-AOP1379.'
ieee: 'J. Alt, L. Erdös, T. H. Krüger, and D. J. Schröder, “Correlated random matrices:
Band rigidity and edge universality,” Annals of Probability, vol. 48, no.
2. Institute of Mathematical Statistics, pp. 963–1001, 2020.'
ista: 'Alt J, Erdös L, Krüger TH, Schröder DJ. 2020. Correlated random matrices:
Band rigidity and edge universality. Annals of Probability. 48(2), 963–1001.'
mla: 'Alt, Johannes, et al. “Correlated Random Matrices: Band Rigidity and Edge
Universality.” Annals of Probability, vol. 48, no. 2, Institute of Mathematical
Statistics, 2020, pp. 963–1001, doi:10.1214/19-AOP1379.'
short: J. Alt, L. Erdös, T.H. Krüger, D.J. Schröder, Annals of Probability 48 (2020)
963–1001.
date_created: 2019-03-28T09:20:08Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2024-02-22T14:34:33Z
day: '01'
department:
- _id: LaEr
doi: 10.1214/19-AOP1379
ec_funded: 1
external_id:
arxiv:
- '1804.07744'
isi:
- '000528269100013'
intvolume: ' 48'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
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url: https://arxiv.org/abs/1804.07744
month: '03'
oa: 1
oa_version: Preprint
page: 963-1001
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
publication: Annals of Probability
publication_identifier:
issn:
- 0091-1798
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
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title: 'Correlated random matrices: Band rigidity and edge universality'
type: journal_article
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...
---
_id: '6185'
abstract:
- lang: eng
text: For complex Wigner-type matrices, i.e. Hermitian random matrices with independent,
not necessarily identically distributed entries above the diagonal, we show that
at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue
statistics are universal and form a Pearcey process. Since the density of states
typically exhibits only square root or cubic root cusp singularities, our work
complements previous results on the bulk and edge universality and it thus completes
the resolution of the Wigner–Dyson–Mehta universality conjecture for the last
remaining universality type in the complex Hermitian class. Our analysis holds
not only for exact cusps, but approximate cusps as well, where an extended Pearcey
process emerges. As a main technical ingredient we prove an optimal local law
at the cusp for both symmetry classes. This result is also the key input in the
companion paper (Cipolloni et al. in Pure Appl Anal, 2018. arXiv:1811.04055) where
the cusp universality for real symmetric Wigner-type matrices is proven. The novel
cusp fluctuation mechanism is also essential for the recent results on the spectral
radius of non-Hermitian random matrices (Alt et al. in Spectral radius of random
matrices with independent entries, 2019. arXiv:1907.13631), and the non-Hermitian
edge universality (Cipolloni et al. in Edge universality for non-Hermitian random
matrices, 2019. arXiv:1908.00969).
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). The authors are very grateful to Johannes Alt for numerous discussions
on the Dyson equation and for his invaluable help in adjusting [10] to the needs
of the present work.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Torben H
full_name: Krüger, Torben H
id: 3020C786-F248-11E8-B48F-1D18A9856A87
last_name: Krüger
orcid: 0000-0002-4821-3297
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: 'Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices I:
Local law and the complex Hermitian case. Communications in Mathematical Physics.
2020;378:1203-1278. doi:10.1007/s00220-019-03657-4'
apa: 'Erdös, L., Krüger, T. H., & Schröder, D. J. (2020). Cusp universality
for random matrices I: Local law and the complex Hermitian case. Communications
in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s00220-019-03657-4'
chicago: 'Erdös, László, Torben H Krüger, and Dominik J Schröder. “Cusp Universality
for Random Matrices I: Local Law and the Complex Hermitian Case.” Communications
in Mathematical Physics. Springer Nature, 2020. https://doi.org/10.1007/s00220-019-03657-4.'
ieee: 'L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random
matrices I: Local law and the complex Hermitian case,” Communications in Mathematical
Physics, vol. 378. Springer Nature, pp. 1203–1278, 2020.'
ista: 'Erdös L, Krüger TH, Schröder DJ. 2020. Cusp universality for random matrices
I: Local law and the complex Hermitian case. Communications in Mathematical Physics.
378, 1203–1278.'
mla: 'Erdös, László, et al. “Cusp Universality for Random Matrices I: Local Law
and the Complex Hermitian Case.” Communications in Mathematical Physics,
vol. 378, Springer Nature, 2020, pp. 1203–78, doi:10.1007/s00220-019-03657-4.'
short: L. Erdös, T.H. Krüger, D.J. Schröder, Communications in Mathematical Physics
378 (2020) 1203–1278.
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date_published: 2020-09-01T00:00:00Z
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doi: 10.1007/s00220-019-03657-4
ec_funded: 1
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isi:
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month: '09'
oa: 1
oa_version: Published Version
page: 1203-1278
project:
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call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Communications in Mathematical Physics
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eissn:
- 1432-0916
issn:
- 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Cusp universality for random matrices I: Local law and the complex Hermitian
case'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
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...
---
_id: '6358'
abstract:
- lang: eng
text: We study dynamical optimal transport metrics between density matricesassociated
to symmetric Dirichlet forms on finite-dimensional C∗-algebras. Our settingcovers arbitrary skew-derivations and it provides a unified framework that simultaneously generalizes recently constructed transport metrics for Markov chains, Lindblad equations, and the Fermi Ornstein–Uhlenbeck semigroup. We develop a non-nommutative
differential calculus that allows us to obtain non-commutative Ricci curvature bounds, logarithmic Sobolev inequalities, transport-entropy inequalities, andspectral
gap estimates.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Eric A.
full_name: Carlen, Eric A.
last_name: Carlen
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
citation:
ama: Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional
inequalities in dissipative quantum systems. Journal of Statistical Physics.
2020;178(2):319-378. doi:10.1007/s10955-019-02434-w
apa: Carlen, E. A., & Maas, J. (2020). Non-commutative calculus, optimal transport
and functional inequalities in dissipative quantum systems. Journal of Statistical
Physics. Springer Nature. https://doi.org/10.1007/s10955-019-02434-w
chicago: Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport
and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical
Physics. Springer Nature, 2020. https://doi.org/10.1007/s10955-019-02434-w.
ieee: E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and
functional inequalities in dissipative quantum systems,” Journal of Statistical
Physics, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.
ista: Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional
inequalities in dissipative quantum systems. Journal of Statistical Physics.
178(2), 319–378.
mla: Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport
and Functional Inequalities in Dissipative Quantum Systems.” Journal of Statistical
Physics, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:10.1007/s10955-019-02434-w.
short: E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378.
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oa_version: Published Version
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name: IST Austria Open Access Fund
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call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 260482E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: ' F06504'
name: Taming Complexity in Partial Di erential Systems
publication: Journal of Statistical Physics
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- '15729613'
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publisher: Springer Nature
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related_material:
link:
- relation: erratum
url: https://doi.org/10.1007/s10955-020-02671-4
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title: Non-commutative calculus, optimal transport and functional inequalities in
dissipative quantum systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
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...
---
_id: '6359'
abstract:
- lang: eng
text: The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate
SDEs with irregular drift coefficients is considered. In the case of α-Hölder
drift in the recent literature the rate α/2 was proved in many related situations.
By exploiting the regularising effect of the noise more efficiently, we show that
the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to
Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients.
article_number: '82'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Konstantinos
full_name: Dareiotis, Konstantinos
last_name: Dareiotis
- first_name: Mate
full_name: Gerencser, Mate
id: 44ECEDF2-F248-11E8-B48F-1D18A9856A87
last_name: Gerencser
citation:
ama: Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama
scheme with irregular drift. Electronic Journal of Probability. 2020;25.
doi:10.1214/20-EJP479
apa: Dareiotis, K., & Gerencser, M. (2020). On the regularisation of the noise
for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability.
Institute of Mathematical Statistics. https://doi.org/10.1214/20-EJP479
chicago: Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of
the Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal
of Probability. Institute of Mathematical Statistics, 2020. https://doi.org/10.1214/20-EJP479.
ieee: K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the
Euler-Maruyama scheme with irregular drift,” Electronic Journal of Probability,
vol. 25. Institute of Mathematical Statistics, 2020.
ista: Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the
Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability.
25, 82.
mla: Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the
Noise for the Euler-Maruyama Scheme with Irregular Drift.” Electronic Journal
of Probability, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:10.1214/20-EJP479.
short: K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020).
date_created: 2019-04-30T07:40:17Z
date_published: 2020-07-16T00:00:00Z
date_updated: 2023-10-16T09:22:50Z
day: '16'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1214/20-EJP479
external_id:
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- '1812.04583'
isi:
- '000550150700001'
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has_accepted_license: '1'
intvolume: ' 25'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Electronic Journal of Probability
publication_identifier:
eissn:
- 1083-6489
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the regularisation of the noise for the Euler-Maruyama scheme with irregular
drift
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...