[{"intvolume":"        10","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573974"}],"publication_status":"published","language":[{"iso":"eng"}],"month":"12","day":"01","quality_controlled":"1","date_published":"1993-12-01T00:00:00Z","author":[{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner"},{"first_name":"Tiow","last_name":"Tan","full_name":"Tan, Tiow"}],"doi":"10.1007/BF02573974","date_updated":"2022-03-28T14:58:16Z","article_processing_charge":"No","_id":"4040","year":"1993","page":"197 - 213","volume":10,"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"apa":"Edelsbrunner, H., &#38; Tan, T. (1993). An upper bound for conforming Delaunay triangulations. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573974\">https://doi.org/10.1007/BF02573974</a>","ieee":"H. Edelsbrunner and T. Tan, “An upper bound for conforming Delaunay triangulations,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 197–213, 1993.","chicago":"Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay Triangulations.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573974\">https://doi.org/10.1007/BF02573974</a>.","short":"H. Edelsbrunner, T. Tan, Discrete &#38; Computational Geometry 10 (1993) 197–213.","ista":"Edelsbrunner H, Tan T. 1993. An upper bound for conforming Delaunay triangulations. Discrete &#38; Computational Geometry. 10(1), 197–213.","mla":"Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay Triangulations.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 197–213, doi:<a href=\"https://doi.org/10.1007/BF02573974\">10.1007/BF02573974</a>.","ama":"Edelsbrunner H, Tan T. An upper bound for conforming Delaunay triangulations. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):197-213. doi:<a href=\"https://doi.org/10.1007/BF02573974\">10.1007/BF02573974</a>"},"publication_identifier":{"issn":["0179-5376"]},"acknowledgement":"Research of the first author is supported by the National Science Foundation under Grant CCR-8921421 and under the Alan T. Waterman award, Grant CCR-9118874. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. Work of the second author was conducted while he was on study leave at the University of Illinois. ","status":"public","article_type":"original","issue":"1","oa_version":"None","date_created":"2018-12-11T12:06:35Z","publist_id":"2084","title":"An upper bound for conforming Delaunay triangulations","publication":"Discrete & Computational Geometry","publisher":"Springer","abstract":[{"text":"A plane geometric graph C in ℝ2 conforms to another such graph G if each edge of G is the union of some edges of C. It is proved that, for every G with n vertices and m edges, there is a completion of a Delaunay triangulation of O(m2 n) points that conforms to G. The algorithm that constructs the points is also described.","lang":"eng"}],"extern":"1"},{"status":"public","acknowledgement":"National Science Foundation under grant CCR-89- 21421.","issue":"2","article_type":"original","citation":{"short":"H. Edelsbrunner, R. Seidel, M. Sharir, SIAM Journal on Computing 22 (1993) 418–429.","ista":"Edelsbrunner H, Seidel R, Sharir M. 1993. On the zone theorem for hyperplane arrangements. SIAM Journal on Computing. 22(2), 418–429.","mla":"Edelsbrunner, Herbert, et al. “On the Zone Theorem for Hyperplane Arrangements.” <i>SIAM Journal on Computing</i>, vol. 22, no. 2, SIAM, 1993, pp. 418–29, doi:<a href=\"https://doi.org/10.1137/0222031\">10.1137/0222031</a>.","ama":"Edelsbrunner H, Seidel R, Sharir M. On the zone theorem for hyperplane arrangements. <i>SIAM Journal on Computing</i>. 1993;22(2):418-429. doi:<a href=\"https://doi.org/10.1137/0222031\">10.1137/0222031</a>","apa":"Edelsbrunner, H., Seidel, R., &#38; Sharir, M. (1993). On the zone theorem for hyperplane arrangements. <i>SIAM Journal on Computing</i>. SIAM. <a href=\"https://doi.org/10.1137/0222031\">https://doi.org/10.1137/0222031</a>","ieee":"H. Edelsbrunner, R. Seidel, and M. Sharir, “On the zone theorem for hyperplane arrangements,” <i>SIAM Journal on Computing</i>, vol. 22, no. 2. SIAM, pp. 418–429, 1993.","chicago":"Edelsbrunner, Herbert, Raimund Seidel, and Micha Sharir. “On the Zone Theorem for Hyperplane Arrangements.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href=\"https://doi.org/10.1137/0222031\">https://doi.org/10.1137/0222031</a>."},"publication_identifier":{"issn":["0097-5397"]},"volume":22,"page":"418 - 429","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"4041","year":"1993","abstract":[{"lang":"eng","text":"The zone theorem for an arrangement of n hyperplanes in d-dimensional real space says that the total number of faces bounding the cells intersected by another hyperplane is O(n(d-1)). This result is the basis of a time-optimal incremental algorithm that constructs a hyperplane arrangement and has a host of other algorithmic and combinatorial applications. Unfortunately, the original proof of the zone theorem, for d greater-than-or-equal-to 3, turned out to contain a serious and irreparable error. This paper presents a new proof of the theorem. The proof is based on an inductive argument, which also applies in the case of pseudohyperplane arrangements. The fallacies of the old proof along with some ways of partially saving that approach are briefly discussed."}],"extern":"1","publication":"SIAM Journal on Computing","title":"On the zone theorem for hyperplane arrangements","publisher":"SIAM","date_created":"2018-12-11T12:06:35Z","oa_version":"None","publist_id":"2085","day":"01","month":"04","language":[{"iso":"eng"}],"intvolume":"        22","main_file_link":[{"url":"https://epubs.siam.org/doi/10.1137/0222031"}],"publication_status":"published","date_published":"1993-04-01T00:00:00Z","author":[{"first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Raimund","last_name":"Seidel","full_name":"Seidel, Raimund"},{"last_name":"Sharir","first_name":"Micha","full_name":"Sharir, Micha"}],"article_processing_charge":"No","date_updated":"2022-03-29T13:25:02Z","doi":"10.1137/0222031","scopus_import":"1","quality_controlled":"1"},{"extern":"1","abstract":[{"lang":"eng","text":"It is shown that a triangulation of a set of n points in the plane that minimizes the maximum edge length can be computed in time 0(n2). The algorithm is reasonably easy to implement and is based on the theorem that there is a triangulation with minmax edge length that contains the relative neighborhood graph of the points as a subgraph. With minor modifications the algorithm works for arbitrary normed metrics."}],"publisher":"SIAM","title":"A quadratic time algorithm for the minmax length triangulation","publication":"SIAM Journal on Computing","publist_id":"2086","oa_version":"None","date_created":"2018-12-11T12:06:36Z","article_type":"original","issue":"3","acknowledgement":"The authors thank an anonymous referee for suggestions on the organization of this paper.","status":"public","publication_identifier":{"issn":["0097-5397"]},"citation":{"apa":"Edelsbrunner, H., &#38; Tan, T. (1993). A quadratic time algorithm for the minmax length triangulation. <i>SIAM Journal on Computing</i>. SIAM. <a href=\"https://doi.org/10.1137/0222036 \">https://doi.org/10.1137/0222036 </a>","ieee":"H. Edelsbrunner and T. Tan, “A quadratic time algorithm for the minmax length triangulation,” <i>SIAM Journal on Computing</i>, vol. 22, no. 3. SIAM, pp. 527–551, 1993.","chicago":"Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the Minmax Length Triangulation.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href=\"https://doi.org/10.1137/0222036 \">https://doi.org/10.1137/0222036 </a>.","short":"H. Edelsbrunner, T. Tan, SIAM Journal on Computing 22 (1993) 527–551.","mla":"Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the Minmax Length Triangulation.” <i>SIAM Journal on Computing</i>, vol. 22, no. 3, SIAM, 1993, pp. 527–51, doi:<a href=\"https://doi.org/10.1137/0222036 \">10.1137/0222036 </a>.","ista":"Edelsbrunner H, Tan T. 1993. A quadratic time algorithm for the minmax length triangulation. SIAM Journal on Computing. 22(3), 527–551.","ama":"Edelsbrunner H, Tan T. A quadratic time algorithm for the minmax length triangulation. <i>SIAM Journal on Computing</i>. 1993;22(3):527-551. doi:<a href=\"https://doi.org/10.1137/0222036 \">10.1137/0222036 </a>"},"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"527 - 551","volume":22,"year":"1993","_id":"4042","date_updated":"2022-03-30T07:43:13Z","doi":"10.1137/0222036 ","article_processing_charge":"No","date_published":"1993-06-01T00:00:00Z","author":[{"last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"full_name":"Tan, Tiow","first_name":"Tiow","last_name":"Tan"}],"quality_controlled":"1","scopus_import":"1","day":"01","language":[{"iso":"eng"}],"month":"06","publication_status":"published","intvolume":"        22","main_file_link":[{"url":"https://epubs.siam.org/doi/10.1137/0222036"}]},{"publication_status":"published","intvolume":"        10","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573962"}],"language":[{"iso":"eng"}],"month":"12","day":"01","quality_controlled":"1","scopus_import":"1","date_updated":"2022-03-28T14:10:59Z","doi":"10.1007/BF02573962","article_processing_charge":"No","author":[{"full_name":"Bern, Marshall","last_name":"Bern","first_name":"Marshall"},{"full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833"},{"first_name":"David","last_name":"Eppstein","full_name":"Eppstein, David"},{"first_name":"Stephen","last_name":"Mitchell","full_name":"Mitchell, Stephen"},{"last_name":"Tan","first_name":"Tiow","full_name":"Tan, Tiow"}],"date_published":"1993-12-01T00:00:00Z","year":"1993","_id":"4044","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"47 - 65","volume":10,"publication_identifier":{"issn":["0179-5376"]},"citation":{"ama":"Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. Edge insertion for optimal triangulations. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):47-65. doi:<a href=\"https://doi.org/10.1007/BF02573962\">10.1007/BF02573962</a>","ista":"Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. 1993. Edge insertion for optimal triangulations. Discrete &#38; Computational Geometry. 10(1), 47–65.","short":"M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, T. Tan, Discrete &#38; Computational Geometry 10 (1993) 47–65.","mla":"Bern, Marshall, et al. “Edge Insertion for Optimal Triangulations.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 47–65, doi:<a href=\"https://doi.org/10.1007/BF02573962\">10.1007/BF02573962</a>.","ieee":"M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, and T. Tan, “Edge insertion for optimal triangulations,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 47–65, 1993.","chicago":"Bern, Marshall, Herbert Edelsbrunner, David Eppstein, Stephen Mitchell, and Tiow Tan. “Edge Insertion for Optimal Triangulations.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573962\">https://doi.org/10.1007/BF02573962</a>.","apa":"Bern, M., Edelsbrunner, H., Eppstein, D., Mitchell, S., &#38; Tan, T. (1993). Edge insertion for optimal triangulations. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573962\">https://doi.org/10.1007/BF02573962</a>"},"article_type":"original","issue":"1","acknowledgement":"The authors thank two anonymous referees for suggestions on improving the style of this paper. The research of the second' author was supported by the National Science Foundation under Grant No. CCR-8921421 and under the Alan T. Waterman award, Grant No. CCR-9118874. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. Part of the work was done while the second, third, and fourth authors visited the Xerox Palo Alto Research Center,\r\nand while the fifth author was on study leave at the University of Illinois. ","status":"public","publist_id":"2082","oa_version":"None","date_created":"2018-12-11T12:06:36Z","publisher":"Springer","title":"Edge insertion for optimal triangulations","publication":"Discrete & Computational Geometry","extern":"1","abstract":[{"text":"Edge insertion iteratively improves a triangulation of a finite point set in ℜ2 by adding a new edge, deleting old edges crossing the new edge, and retriangulating the polygonal regions on either side of the new edge. This paper presents an abstract view of the edge insertion paradigm, and then shows that it gives polynomial-time algorithms for several types of optimal triangulations, including minimizing the maximum slope of a piecewise-linear interpolating surface.","lang":"eng"}]},{"_id":"4045","year":"1993","page":"183 - 196","volume":10,"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ama":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M. Diameter, width, closest line pair, and parametric searching. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):183-196. doi:<a href=\"https://doi.org/10.1007/BF02573973\">10.1007/BF02573973</a>","mla":"Chazelle, Bernard, et al. “Diameter, Width, Closest Line Pair, and Parametric Searching.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 183–96, doi:<a href=\"https://doi.org/10.1007/BF02573973\">10.1007/BF02573973</a>.","ista":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1993. Diameter, width, closest line pair, and parametric searching. Discrete &#38; Computational Geometry. 10(1), 183–196.","short":"B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Discrete &#38; Computational Geometry 10 (1993) 183–196.","ieee":"B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “Diameter, width, closest line pair, and parametric searching,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 183–196, 1993.","chicago":"Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir. “Diameter, Width, Closest Line Pair, and Parametric Searching.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573973\">https://doi.org/10.1007/BF02573973</a>.","apa":"Chazelle, B., Edelsbrunner, H., Guibas, L., &#38; Sharir, M. (1993). Diameter, width, closest line pair, and parametric searching. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573973\">https://doi.org/10.1007/BF02573973</a>"},"publication_identifier":{"issn":["0179-5376"]},"status":"public","acknowledgement":"*Work by Bernard Chazelle was supported by NSF Grant CCR-90-02352. Work by Herbert Edelsbrunner was supported by NSF Grant CCR-89-21421. Work by Leonidas Guibas and Micha Sharir was supported by a grant from the U.S.-Israeli Binational Science Foundation. Work by Micha Sharir was also supported by ONR Grant N00014-90-J-1284, by NSF Grant CCR-89-01484, and by grants from the Fund for Basic Research administered by the Israeli Academy of Sciences, and the G.I.F., the German-Israeli Foundation for Scientific Research and Development.","article_type":"original","issue":"1","oa_version":"None","date_created":"2018-12-11T12:06:37Z","publist_id":"2083","title":"Diameter, width, closest line pair, and parametric searching","publication":"Discrete & Computational Geometry","publisher":"Springer","abstract":[{"text":"We apply Megiddo's parametric searching technique to several geometric optimization problems and derive significantly improved solutions for them. We obtain, for any fixed ε&gt;0, an O(n1+ε) algorithm for computing the diameter of a point set in 3-space, an O(8/5+ε) algorithm for computing the width of such a set, and on O(n8/5+ε) algorithm for computing the closest pair in a set of n lines in space. All these algorithms are deterministic.","lang":"eng"}],"extern":"1","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573973"}],"intvolume":"        10","publication_status":"published","language":[{"iso":"eng"}],"month":"12","day":"01","scopus_import":"1","quality_controlled":"1","date_published":"1993-12-01T00:00:00Z","author":[{"full_name":"Chazelle, Bernard","last_name":"Chazelle","first_name":"Bernard"},{"orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"full_name":"Guibas, Leonidas","last_name":"Guibas","first_name":"Leonidas"},{"full_name":"Sharir, Micha","last_name":"Sharir","first_name":"Micha"}],"date_updated":"2022-03-28T14:50:42Z","doi":"10.1007/BF02573973","article_processing_charge":"No"},{"day":"01","pmid":1,"language":[{"iso":"eng"}],"month":"11","publication_status":"published","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.1993.tb00213.x"}],"intvolume":"         5","doi":"10.1111/j.1460-9568.1993.tb00213.x","date_updated":"2022-03-28T13:33:18Z","article_processing_charge":"No","date_published":"1993-11-01T00:00:00Z","author":[{"full_name":"Lindholm, Dan","first_name":"Dan","last_name":"Lindholm"},{"last_name":"Dechant","first_name":"Georg","full_name":"Dechant, Georg"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J"},{"full_name":"Thoenen, Hans","last_name":"Thoenen","first_name":"Hans"}],"quality_controlled":"1","scopus_import":"1","article_type":"original","external_id":{"pmid":["7904521 "]},"issue":"11","status":"public","publication_identifier":{"issn":["0953-816X"]},"citation":{"mla":"Lindholm, Dan, et al. “Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” <i>European Journal of Neuroscience</i>, vol. 5, no. 11, Wiley-Blackwell, 1993, pp. 1455–64, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">10.1111/j.1460-9568.1993.tb00213.x</a>.","short":"D. Lindholm, G. Dechant, C.-P.J. Heisenberg, H. Thoenen, European Journal of Neuroscience 5 (1993) 1455–1464.","ista":"Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. 1993. Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. European Journal of Neuroscience. 5(11), 1455–1464.","ama":"Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. <i>European Journal of Neuroscience</i>. 1993;5(11):1455-1464. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">10.1111/j.1460-9568.1993.tb00213.x</a>","apa":"Lindholm, D., Dechant, G., Heisenberg, C.-P. J., &#38; Thoenen, H. (1993). Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>","ieee":"D. Lindholm, G. Dechant, C.-P. J. Heisenberg, and H. Thoenen, “Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity,” <i>European Journal of Neuroscience</i>, vol. 5, no. 11. Wiley-Blackwell, pp. 1455–1464, 1993.","chicago":"Lindholm, Dan, Georg Dechant, Carl-Philipp J Heisenberg, and Hans Thoenen. “Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>."},"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"1455 - 1464","volume":5,"year":"1993","_id":"4175","extern":"1","abstract":[{"lang":"eng","text":"We have studied the effects of different neurotrophins on the survival and proliferation of rat cerebellar granule cells in culture. These neurons express trkB and trkC, the putative neuronal receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) respectively. Binding studies using iodinated BDNF and NT-3 demonstrated that both BDNF and NT-3 bind to the cerebellar granule neurons with a similar affinity of approximately 2 x 10(-9) M. The number of receptors per granule cell was surprisingly high, approximately 30 x 10(-4) and 2 x 10(5) for BDNF and NT-3, respectively. Both NT-3 and BDNF elevated c-fos mRNA in the granule neurons, but only BDNF up-regulated the mRNA encoding the low-affinity neurotrophin receptor (p75). In contrast to NT-3, BDNF acted as a survival factor for the granule neurons. BDNF also induced sprouting of the granule neurons and significantly protected them against neurotoxicity induced by high (1 mM) glutamate concentrations. Cultured granule neurons also expressed low levels of BDNF mRNA which were increased by kainic acid, a glutamate receptor agonist. Thus, BDNF, but not NT-3, is a survival factor for cultured cerebellar granule neurons and activation of glutamate receptor(s) up-regulates BDNF expression in these cells."}],"publisher":"Wiley-Blackwell","title":"Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity","publication":"European Journal of Neuroscience","publist_id":"1943","oa_version":"None","date_created":"2018-12-11T12:07:24Z"},{"year":"1993","_id":"4177","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":122,"page":"443 - 450","publication_identifier":{"issn":["0021-9525"]},"citation":{"ista":"Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi M, Leingärtner A, Heisenberg C-PJ, Tesarollo L, Parada L, Thoenen H. 1993. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. Journal of Cell Biology. 122(2), 443–450.","short":"D. Lindholm, E. Castrén, P. Tsoulfas, R. Kolbeck, M. Berzaghi, A. Leingärtner, C.-P.J. Heisenberg, L. Tesarollo, L. Parada, H. Thoenen, Journal of Cell Biology 122 (1993) 443–450.","mla":"Lindholm, Dan, et al. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>, vol. 122, no. 2, Rockefeller University Press, 1993, pp. 443–50, doi:<a href=\"https://doi.org/10.1083/jcb.122.2.443\">10.1083/jcb.122.2.443</a>.","ama":"Lindholm D, Castrén E, Tsoulfas P, et al. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. <i>Journal of Cell Biology</i>. 1993;122(2):443-450. doi:<a href=\"https://doi.org/10.1083/jcb.122.2.443\">10.1083/jcb.122.2.443</a>","apa":"Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M., Leingärtner, A., … Thoenen, H. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.122.2.443\">https://doi.org/10.1083/jcb.122.2.443</a>","chicago":"Lindholm, Dan, Eero Castrén, Pantelis Tsoulfas, Roland Kolbeck, Maria Berzaghi, Axel Leingärtner, Carl-Philipp J Heisenberg, Lino Tesarollo, Luis Parada, and Hans Thoenen. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 1993. <a href=\"https://doi.org/10.1083/jcb.122.2.443\">https://doi.org/10.1083/jcb.122.2.443</a>.","ieee":"D. Lindholm <i>et al.</i>, “Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation,” <i>Journal of Cell Biology</i>, vol. 122, no. 2. Rockefeller University Press, pp. 443–450, 1993."},"issue":"2","article_type":"original","external_id":{"pmid":["8320266"]},"acknowledgement":"E. Castrtn is an Alexander von Humboldt fellow. M. Berzaghi is supported by a scholarship from CNPQ, Brasil. L. F. Parada, P. Tsoulfas, and L. Tesarollo were supported by a National Institutes of Health grant. We thank D. Stratmann and K. Angermeyer for skillful technical assistance; I. Hajjar for secretarial work and Dr. R. G~rtner for help with\r\ninducing hypothyroidism; Dr. W. Hunzieker for the calbindin-28 kD eDNA; Dr. M. Fishman for the GAP-43 eDNA; and Dr. Y.-A. Barde for critical comments.","status":"public","oa":1,"publist_id":"1942","date_created":"2018-12-11T12:07:25Z","oa_version":"None","publisher":"Rockefeller University Press","publication":"Journal of Cell Biology","title":"Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation","extern":"1","abstract":[{"lang":"eng","text":"Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation."}],"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119654/"}],"intvolume":"       122","month":"07","language":[{"iso":"eng"}],"day":"15","pmid":1,"quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","doi":"10.1083/jcb.122.2.443","date_updated":"2022-03-24T12:59:20Z","author":[{"full_name":"Lindholm, Dan","first_name":"Dan","last_name":"Lindholm"},{"full_name":"Castrén, Eero","first_name":"Eero","last_name":"Castrén"},{"last_name":"Tsoulfas","first_name":"Pantelis","full_name":"Tsoulfas, Pantelis"},{"first_name":"Roland","last_name":"Kolbeck","full_name":"Kolbeck, Roland"},{"first_name":"Maria","last_name":"Berzaghi","full_name":"Berzaghi, Maria"},{"first_name":"Axel","last_name":"Leingärtner","full_name":"Leingärtner, Axel"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"},{"full_name":"Tesarollo, Lino","last_name":"Tesarollo","first_name":"Lino"},{"full_name":"Parada, Luis","last_name":"Parada","first_name":"Luis"},{"first_name":"Hans","last_name":"Thoenen","full_name":"Thoenen, Hans"}],"date_published":"1993-07-15T00:00:00Z"},{"language":[{"iso":"eng"}],"month":"01","day":"01","pmid":1,"publication_status":"published","intvolume":"        91","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF01435990"}],"quality_controlled":"1","scopus_import":"1","doi":"10.1007/BF01435990","date_updated":"2022-06-02T10:00:56Z","article_processing_charge":"No","date_published":"1993-01-01T00:00:00Z","author":[{"first_name":"Linda","last_name":"Partridge","full_name":"Partridge, Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"publication_identifier":{"issn":["0016-6707"]},"citation":{"mla":"Partridge, Linda, and Nicholas H. Barton. “Evolution of Aging: Testing the Theory Using Drosophila.” <i>Genetica</i>, vol. 91, no. 1–3, Springer, 1993, pp. 89–98, doi:<a href=\"https://doi.org/10.1007/BF01435990\">10.1007/BF01435990</a>.","ista":"Partridge L, Barton NH. 1993. Evolution of aging: Testing the theory using Drosophila. Genetica. 91(1–3), 89–98.","short":"L. Partridge, N.H. Barton, Genetica 91 (1993) 89–98.","ama":"Partridge L, Barton NH. Evolution of aging: Testing the theory using Drosophila. <i>Genetica</i>. 1993;91(1-3):89-98. doi:<a href=\"https://doi.org/10.1007/BF01435990\">10.1007/BF01435990</a>","apa":"Partridge, L., &#38; Barton, N. H. (1993). Evolution of aging: Testing the theory using Drosophila. <i>Genetica</i>. Springer. <a href=\"https://doi.org/10.1007/BF01435990\">https://doi.org/10.1007/BF01435990</a>","ieee":"L. Partridge and N. H. Barton, “Evolution of aging: Testing the theory using Drosophila,” <i>Genetica</i>, vol. 91, no. 1–3. Springer, pp. 89–98, 1993.","chicago":"Partridge, Linda, and Nicholas H Barton. “Evolution of Aging: Testing the Theory Using Drosophila.” <i>Genetica</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF01435990\">https://doi.org/10.1007/BF01435990</a>."},"external_id":{"pmid":["8125281 "]},"article_type":"original","issue":"1-3","status":"public","year":"1993","_id":"4299","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"89 - 98","volume":91,"extern":"1","abstract":[{"lang":"eng","text":"Evolutionary explanations of aging (or senescence) fall into two classes. First, organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction or high pre-adult survival. Second, the life history might be depressed below this optimal compromise by the influx of deleterious mutations; since selection against late-acting mutations is weaker, deleterious mutations will impose a greater load on late life. We discuss ways in which these theories might be investigated and distinguished, with reference to experimental work withDrosophila. While genetic correlations between life history traits determine the immediate response to selection, they are hard to measure, and may not reflect the fundamental constraints on life history. Long term selection experiments are more likely to be informative. The third approach of using experimental manipulations suffers from some of the same problems as measures of genetic correlations; however, these two approaches may be fruitful when used together. The experimental results so far suggest that aging inDrosophila has evolved in part as a consequence of selection for an optimal life history, and in part as a result of accumulation of predominantly late-acting deleterious mutations. Quantification of these effects presents a major challenge for the future."}],"publist_id":"1769","oa_version":"None","date_created":"2018-12-11T12:08:07Z","publisher":"Springer","title":"Evolution of aging: Testing the theory using Drosophila","publication":"Genetica"},{"extern":"1","abstract":[{"lang":"eng","text":"Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge."}],"publist_id":"1766","oa_version":"None","date_created":"2018-12-11T12:08:07Z","publisher":"Nature Publishing Group","title":"Optimality, mutation and the evolution of ageing","publication":"Nature","publication_identifier":{"issn":["0028-0836"]},"citation":{"ieee":"L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” <i>Nature</i>, vol. 362. Nature Publishing Group, pp. 305–311, 1993.","chicago":"Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>.","apa":"Partridge, L., &#38; Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>","ama":"Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. <i>Nature</i>. 1993;362:305-311. doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>","ista":"Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.","mla":"Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>.","short":"L. Partridge, N.H. Barton, Nature 362 (1993) 305–311."},"external_id":{"pmid":["8455716"]},"article_type":"original","acknowledgement":"We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey. A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful comments and C. Roper for providing the data for Fig. 1. Our work was supported by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.","status":"public","year":"1993","_id":"4300","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"305 - 311","volume":362,"quality_controlled":"1","date_updated":"2022-03-24T12:22:38Z","doi":"10.1038/362305a0","article_processing_charge":"No","date_published":"1993-03-25T00:00:00Z","author":[{"last_name":"Partridge","first_name":"Linda","full_name":"Partridge, Linda"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"}],"language":[{"iso":"eng"}],"month":"03","day":"25","pmid":1,"publication_status":"published","intvolume":"       362","main_file_link":[{"url":"https://www.nature.com/articles/362305a0"}]},{"publisher":"Oxford University Press","publication":"Hybrid zones and the evolutionary process","title":"Genetic analysis of hybrid zones","publist_id":"1764","date_created":"2018-12-11T12:08:08Z","oa_version":"None","article_processing_charge":"No","doi":"10.1046/j.1420-9101.1994.7050631.x","date_updated":"2022-03-24T10:36:10Z","author":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Gale","first_name":"Katherine","full_name":"Gale, Katherine"}],"date_published":"1993-01-01T00:00:00Z","editor":[{"full_name":"Harrison, Richard","last_name":"Harrison","first_name":"Richard"}],"extern":"1","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"book_chapter","page":"13 - 45","year":"1993","publication_status":"published","_id":"4301","main_file_link":[{"url":"https://books.google.at/books?hl=en&lr=&id=aFJFkVKskYIC&oi=fnd&pg=PA13&ots=MFf0ehNeKK&sig=Yp6VrwzCJRB-v-iOhI7WZw-xf8w&redir_esc=y#v=onepage&q&f=false"}],"day":"01","status":"public","month":"01","publication_identifier":{"isbn":[" 0-19-506917-X"]},"language":[{"iso":"eng"}],"citation":{"apa":"Barton, N. H., &#38; Gale, K. (1993). Genetic analysis of hybrid zones. In R. Harrison (Ed.), <i>Hybrid zones and the evolutionary process</i> (pp. 13–45). Oxford University Press. <a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>","chicago":"Barton, Nicholas H, and Katherine Gale. “Genetic Analysis of Hybrid Zones.” In <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison, 13–45. Oxford University Press, 1993. <a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>.","ieee":"N. H. Barton and K. Gale, “Genetic analysis of hybrid zones,” in <i>Hybrid zones and the evolutionary process</i>, R. Harrison, Ed. Oxford University Press, 1993, pp. 13–45.","mla":"Barton, Nicholas H., and Katherine Gale. “Genetic Analysis of Hybrid Zones.” <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison, Oxford University Press, 1993, pp. 13–45, doi:<a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">10.1046/j.1420-9101.1994.7050631.x</a>.","short":"N.H. Barton, K. Gale, in:, R. Harrison (Ed.), Hybrid Zones and the Evolutionary Process, Oxford University Press, 1993, pp. 13–45.","ista":"Barton NH, Gale K. 1993.Genetic analysis of hybrid zones. In: Hybrid zones and the evolutionary process. , 13–45.","ama":"Barton NH, Gale K. Genetic analysis of hybrid zones. In: Harrison R, ed. <i>Hybrid Zones and the Evolutionary Process</i>. Oxford University Press; 1993:13-45. doi:<a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">10.1046/j.1420-9101.1994.7050631.x</a>"}},{"_id":"4302","intvolume":"        62","main_file_link":[{"url":"https://www.cambridge.org/core/journals/genetics-research/article/causes-of-molecular-evolution-by-john-h-gillespie-oxford-university-press-1992-336-pages-price-2500-isbn-0-19-506883-1/FF2B56D0B883F340BEC4E3C068F89F6C"}],"year":"1993","publication_status":"published","volume":62,"page":"77 - 85","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"review","citation":{"ista":"Barton NH. 1993. Review of &#38;quot;The causes of molecular evolution&#38;quot; by J.H. Gillespie. Genetical Research. 62(1), 77–85.","mla":"Barton, Nicholas H. “Review of &#38;quot;The Causes of Molecular Evolution&#38;quot; by J.H. Gillespie.” <i>Genetical Research</i>, vol. 62, no. 1, Cambridge University Press, 1993, pp. 77–85, doi:<a href=\"https://doi.org/10.1017/S001667230003158X \">10.1017/S001667230003158X </a>.","short":"N.H. Barton, Genetical Research 62 (1993) 77–85.","ama":"Barton NH. Review of &#38;quot;The causes of molecular evolution&#38;quot; by J.H. Gillespie. <i>Genetical Research</i>. 1993;62(1):77-85. doi:<a href=\"https://doi.org/10.1017/S001667230003158X \">10.1017/S001667230003158X </a>","apa":"Barton, N. H. (1993). Review of &#38;quot;The causes of molecular evolution&#38;quot; by J.H. Gillespie. <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S001667230003158X \">https://doi.org/10.1017/S001667230003158X </a>","ieee":"N. H. Barton, “Review of &#38;quot;The causes of molecular evolution&#38;quot; by J.H. Gillespie,” <i>Genetical Research</i>, vol. 62, no. 1. Cambridge University Press, pp. 77–85, 1993.","chicago":"Barton, Nicholas H. “Review of &#38;quot;The Causes of Molecular Evolution&#38;quot; by J.H. Gillespie.” <i>Genetical Research</i>. Cambridge University Press, 1993. <a href=\"https://doi.org/10.1017/S001667230003158X \">https://doi.org/10.1017/S001667230003158X </a>."},"month":"01","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0016-6723"]},"status":"public","issue":"1","day":"01","date_created":"2018-12-11T12:08:08Z","oa_version":"None","publist_id":"1763","publication":"Genetical Research","title":"Review of &quot;The causes of molecular evolution&quot; by J.H. Gillespie","publisher":"Cambridge University Press","extern":"1","quality_controlled":"1","date_published":"1993-01-01T00:00:00Z","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H"}],"article_processing_charge":"No","doi":"10.1017/S001667230003158X ","date_updated":"2022-03-23T16:05:31Z"},{"intvolume":"        62","main_file_link":[{"url":"https://www.cambridge.org/core/journals/genetics-research/article/probability-of-fixation-of-a-favoured-allele-in-a-subdivided-population/3257B4AEC7044AFE40436C2DC15FBC4C#article","open_access":"1"}],"publication_status":"published","day":"01","month":"10","language":[{"iso":"eng"}],"date_published":"1993-10-01T00:00:00Z","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"article_processing_charge":"No","date_updated":"2022-03-23T15:41:32Z","doi":"10.1017/S0016672300031748","scopus_import":"1","quality_controlled":"1","volume":62,"page":"149 - 158","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"4303","year":"1993","acknowledgement":"This work was supported by grants from the SERC (GR/H/09928) and NERC (GR/3/8002), and by the Darwin Trust of Edinburgh. Thanks are due to B. Nürnberger for convincing me that population structure does reduce fixation probability, to M. Whitlock for discussions on calculations of effective population size, and to W. G. Hill, P. Keightley and the anonymous referees for their comments.","status":"public","oa":1,"issue":"2","article_type":"original","citation":{"apa":"Barton, N. H. (1993). The probability of fixation of a favoured allele in a subdivided population. <i>Genetics Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672300031748\">https://doi.org/10.1017/S0016672300031748</a>","chicago":"Barton, Nicholas H. “The Probability of Fixation of a Favoured Allele in a Subdivided Population.” <i>Genetics Research</i>. Cambridge University Press, 1993. <a href=\"https://doi.org/10.1017/S0016672300031748\">https://doi.org/10.1017/S0016672300031748</a>.","ieee":"N. H. Barton, “The probability of fixation of a favoured allele in a subdivided population,” <i>Genetics Research</i>, vol. 62, no. 2. Cambridge University Press, pp. 149–158, 1993.","mla":"Barton, Nicholas H. “The Probability of Fixation of a Favoured Allele in a Subdivided Population.” <i>Genetics Research</i>, vol. 62, no. 2, Cambridge University Press, 1993, pp. 149–58, doi:<a href=\"https://doi.org/10.1017/S0016672300031748\">10.1017/S0016672300031748</a>.","ista":"Barton NH. 1993. The probability of fixation of a favoured allele in a subdivided population. Genetics Research. 62(2), 149–158.","short":"N.H. Barton, Genetics Research 62 (1993) 149–158.","ama":"Barton NH. The probability of fixation of a favoured allele in a subdivided population. <i>Genetics Research</i>. 1993;62(2):149-158. doi:<a href=\"https://doi.org/10.1017/S0016672300031748\">10.1017/S0016672300031748</a>"},"publication_identifier":{"issn":["0016-6723"]},"publication":"Genetics Research","title":"The probability of fixation of a favoured allele in a subdivided population","publisher":"Cambridge University Press","date_created":"2018-12-11T12:08:09Z","oa_version":"None","publist_id":"1762","abstract":[{"text":"In a stably subdivided population with symmetric migration, the chance that a favoured allele will be fixed is independent of population structure. However, random extinction introduces an extra component of sampling drift, and reduces the probability of fixation. In this paper, the fixation probability is calculated using the diffusion approximation; comparison with exact solution of the discrete model shows this to be accurate. The key parameters are the rates of selection, migration and extinction, scaled relative to population size (S = 4Ns, M = 4Nm, Λ = 4Nλ); results apply to a haploid model, or to diploids with additive selection. If new colonies derive from many demes, the fixation probability cannot be reduced by more than half. However, if colonies are initially homogeneous, fixation probability can be much reduced. In the limit of low migration and extinction rates (M, Λ 1), it is 2s/{1 + (Λ/MS)(1 −exp(−S))}, whilst in the opposite limit (S  1), it is 4sM/{Λ(Λ + M)}. In the limit of weak selection (M, Λ  1), it is 4sM/{Λ(Λ + M)}. These factors are not the same as the reduction in effective population size (Ne/N), showing that the effects of population structure on selected alleles cannot be understood from the behaviour of neutral markers.","lang":"eng"}],"extern":"1"},{"publication_status":"published","year":"1993","_id":"4304","intvolume":"         3","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/096098229390036N?via%3Dihub"}],"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"797 - 799","volume":3,"publication_identifier":{"issn":["0960-9822"]},"language":[{"iso":"eng"}],"month":"11","citation":{"ista":"Barton NH. 1993. Why species and subspecies? Current Biology. 3(11), 797–799.","mla":"Barton, Nicholas H. “Why Species and Subspecies?” <i>Current Biology</i>, vol. 3, no. 11, Cell Press, 1993, pp. 797–99, doi:<a href=\"https://doi.org/10.1016/0960-9822(93)90036-N\">10.1016/0960-9822(93)90036-N</a>.","short":"N.H. Barton, Current Biology 3 (1993) 797–799.","ama":"Barton NH. Why species and subspecies? <i>Current Biology</i>. 1993;3(11):797-799. doi:<a href=\"https://doi.org/10.1016/0960-9822(93)90036-N\">10.1016/0960-9822(93)90036-N</a>","apa":"Barton, N. H. (1993). Why species and subspecies? <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/0960-9822(93)90036-N\">https://doi.org/10.1016/0960-9822(93)90036-N</a>","ieee":"N. H. Barton, “Why species and subspecies?,” <i>Current Biology</i>, vol. 3, no. 11. Cell Press, pp. 797–799, 1993.","chicago":"Barton, Nicholas H. “Why Species and Subspecies?” <i>Current Biology</i>. Cell Press, 1993. <a href=\"https://doi.org/10.1016/0960-9822(93)90036-N\">https://doi.org/10.1016/0960-9822(93)90036-N</a>."},"article_type":"letter_note","day":"01","issue":"11","status":"public","publist_id":"1761","oa_version":"None","date_created":"2018-12-11T12:08:09Z","publisher":"Cell Press","title":"Why species and subspecies?","publication":"Current Biology","extern":"1","quality_controlled":"1","doi":"10.1016/0960-9822(93)90036-N","date_updated":"2022-03-23T13:19:21Z","article_processing_charge":"No","author":[{"first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"date_published":"1993-11-01T00:00:00Z"},{"month":"01","language":[{"iso":"eng"}],"day":"01","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-57318-6_24"}],"intvolume":"       736","publication_status":"published","quality_controlled":"1","author":[{"last_name":"Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"},{"full_name":"Manna, Zohar","last_name":"Manna","first_name":"Zohar"},{"last_name":"Pnueli","first_name":"Amir","full_name":"Pnueli, Amir"}],"date_published":"1993-01-01T00:00:00Z","editor":[{"last_name":"Grossman","first_name":"Robert","full_name":"Grossman, Robert"},{"first_name":"Anil","last_name":"Nerode","full_name":"Nerode, Anil"},{"last_name":"Ravn","first_name":"Anders","full_name":"Ravn, Anders"},{"last_name":"Rischel","first_name":"Hans","full_name":"Rischel, Hans"}],"article_processing_charge":"No","doi":"10.1007/3-540-57318-6_24","alternative_title":["LNCS"],"date_updated":"2022-03-23T13:13:46Z","conference":{"name":"International Hybrid Systems Workshop"},"citation":{"chicago":"Henzinger, Thomas A, Zohar Manna, and Amir Pnueli. “Towards Refining Temporal Specifications into Hybrid Systems.” In <i>International Hybrid Systems Workshop</i>, edited by Robert Grossman, Anil Nerode, Anders Ravn, and Hans Rischel, 736:60–76. Springer, 1993. <a href=\"https://doi.org/10.1007/3-540-57318-6_24\">https://doi.org/10.1007/3-540-57318-6_24</a>.","ieee":"T. A. Henzinger, Z. Manna, and A. Pnueli, “Towards refining temporal specifications into hybrid systems,” in <i>International Hybrid Systems Workshop</i>, 1993, vol. 736, pp. 60–76.","apa":"Henzinger, T. A., Manna, Z., &#38; Pnueli, A. (1993). Towards refining temporal specifications into hybrid systems. In R. Grossman, A. Nerode, A. Ravn, &#38; H. Rischel (Eds.), <i>International Hybrid Systems Workshop</i> (Vol. 736, pp. 60–76). Springer. <a href=\"https://doi.org/10.1007/3-540-57318-6_24\">https://doi.org/10.1007/3-540-57318-6_24</a>","ama":"Henzinger TA, Manna Z, Pnueli A. Towards refining temporal specifications into hybrid systems. In: Grossman R, Nerode A, Ravn A, Rischel H, eds. <i>International Hybrid Systems Workshop</i>. Vol 736. Springer; 1993:60-76. doi:<a href=\"https://doi.org/10.1007/3-540-57318-6_24\">10.1007/3-540-57318-6_24</a>","mla":"Henzinger, Thomas A., et al. “Towards Refining Temporal Specifications into Hybrid Systems.” <i>International Hybrid Systems Workshop</i>, edited by Robert Grossman et al., vol. 736, Springer, 1993, pp. 60–76, doi:<a href=\"https://doi.org/10.1007/3-540-57318-6_24\">10.1007/3-540-57318-6_24</a>.","short":"T.A. Henzinger, Z. Manna, A. Pnueli, in:, R. Grossman, A. Nerode, A. Ravn, H. Rischel (Eds.), International Hybrid Systems Workshop, Springer, 1993, pp. 60–76.","ista":"Henzinger TA, Manna Z, Pnueli A. 1993. Towards refining temporal specifications into hybrid systems. International Hybrid Systems Workshop. International Hybrid Systems Workshop, LNCS, vol. 736, 60–76."},"publication_identifier":{"isbn":["978-3-540-57318-0"]},"status":"public","acknowledgement":"This research was supported in part by the National Science Foundation under grants CCR-92-00794 and CCR-92-23226, by the Defense Advanced Research Projects Agency under contract NAG2-703, by the United States Air Force Office of Scientific Research under contracts F49620-93-1-0056 and F49620-93-1-0139, and by the European Community ESPRIT Basic Research Action Project 6021 (REACT).","_id":"4506","year":"1993","volume":736,"page":"60 - 76","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"conference","abstract":[{"text":"We propose a formal framework for designing hybrid systems by stepwise refinement. Starting with a specification in hybrid temporal logic, we make successively more transitions explicit until we obtain an executable system.","lang":"eng"}],"extern":"1","date_created":"2018-12-11T12:09:12Z","oa_version":"None","publist_id":"225","publication":"International Hybrid Systems Workshop","title":"Towards refining temporal specifications into hybrid systems","publisher":"Springer"},{"month":"01","language":[{"iso":"eng"}],"day":"01","pmid":1,"publication_status":"published","intvolume":"         8","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739290118W?via%3Dihub"}],"quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","date_updated":"2022-03-21T10:17:07Z","doi":"10.1016/0896-6273(92)90118-W","author":[{"full_name":"Tanabe, Yasuto","first_name":"Yasuto","last_name":"Tanabe"},{"full_name":"Masu, Masayuki","last_name":"Masu","first_name":"Masayuki"},{"first_name":"Takahiro","last_name":"Ishii","full_name":"Ishii, Takahiro"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"date_published":"1992-01-01T00:00:00Z","publication_identifier":{"issn":["0896-6273"]},"citation":{"chicago":"Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” <i>Neuron</i>. Elsevier, 1992. <a href=\"https://doi.org/10.1016/0896-6273(92)90118-W\">https://doi.org/10.1016/0896-6273(92)90118-W</a>.","ieee":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” <i>Neuron</i>, vol. 8, no. 1. Elsevier, pp. 169–179, 1992.","apa":"Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., &#38; Nakanishi, S. (1992). A family of metabotropic glutamate receptors. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(92)90118-W\">https://doi.org/10.1016/0896-6273(92)90118-W</a>","ama":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. <i>Neuron</i>. 1992;8(1):169-179. doi:<a href=\"https://doi.org/10.1016/0896-6273(92)90118-W\">10.1016/0896-6273(92)90118-W</a>","ista":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179.","mla":"Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” <i>Neuron</i>, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:<a href=\"https://doi.org/10.1016/0896-6273(92)90118-W\">10.1016/0896-6273(92)90118-W</a>.","short":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992) 169–179."},"issue":"1","external_id":{"pmid":["1309649 "]},"article_type":"original","acknowledgement":"We are grateful to Noboru Mizuno for helpful discussion and Akira Uesugi for photographic assistance. This work was sup. ported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement\" in accordance with 18 USC Sec-tion 1734 solely to indicate this fact. ","status":"public","year":"1992","_id":"2484","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":8,"page":"169 - 179","extern":"1","abstract":[{"lang":"eng","text":"Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns."}],"publist_id":"4417","date_created":"2018-12-11T11:57:56Z","oa_version":"None","publisher":"Elsevier","publication":"Neuron","title":"A family of metabotropic glutamate receptors"},{"main_file_link":[{"url":"https://academic.oup.com/endo/article-abstract/130/4/1885/2535978"}],"intvolume":"       130","publication_status":"published","month":"04","language":[{"iso":"eng"}],"pmid":1,"day":"01","scopus_import":"1","quality_controlled":"1","author":[{"full_name":"Hori, Seiji","last_name":"Hori","first_name":"Seiji"},{"last_name":"Komatsu","first_name":"Yasato","full_name":"Komatsu, Yasato"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"}],"date_published":"1992-04-01T00:00:00Z","article_processing_charge":"No","doi":"10.1210/endo.130.4.1312429","date_updated":"2022-03-21T09:54:59Z","_id":"2485","year":"1992","volume":130,"page":"1885 - 1895","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","citation":{"apa":"Hori, S., Komatsu, Y., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1992). Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. <i>Endocrinology</i>. The Endocrine Society. <a href=\"https://doi.org/10.1210/endo.130.4.1312429\">https://doi.org/10.1210/endo.130.4.1312429</a>","chicago":"Hori, Seiji, Yasato Komatsu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” <i>Endocrinology</i>. The Endocrine Society, 1992. <a href=\"https://doi.org/10.1210/endo.130.4.1312429\">https://doi.org/10.1210/endo.130.4.1312429</a>.","ieee":"S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors,” <i>Endocrinology</i>, vol. 130, no. 4. The Endocrine Society, pp. 1885–1895, 1992.","short":"S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, S. Nakanishi, Endocrinology 130 (1992) 1885–1895.","mla":"Hori, Seiji, et al. “Distinct Tissue Distribution and Cellular Localization of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” <i>Endocrinology</i>, vol. 130, no. 4, The Endocrine Society, 1992, pp. 1885–95, doi:<a href=\"https://doi.org/10.1210/endo.130.4.1312429\">10.1210/endo.130.4.1312429</a>.","ista":"Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 1992. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 130(4), 1885–1895.","ama":"Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. <i>Endocrinology</i>. 1992;130(4):1885-1895. doi:<a href=\"https://doi.org/10.1210/endo.130.4.1312429\">10.1210/endo.130.4.1312429</a>"},"publication_identifier":{"issn":["0013-7227"]},"status":"public","issue":"4","external_id":{"pmid":["1312429"]},"article_type":"original","date_created":"2018-12-11T11:57:56Z","oa_version":"None","publist_id":"4416","publication":"Endocrinology","title":"Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors","publisher":"The Endocrine Society","abstract":[{"text":"Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse functions in both vascular and nonvascular tissues. This investigation concerns the tissue distribution and cellular localization of rat mRNAs encoding two different subtypes of ET receptors (ET(A) and ET(B)). We isolated 46 cDNA clones from a rat lung cDNA library by hybridization with the bovine ET(A) cDNA. The characterization of these cDNA clones indicated that they represent either the ET(A) or ET(B) cDNA. In situ and blot hybridization analyses revealed that the rat ET(A) mRNA is predominantly expressed in vascular smooth muscle cells of a variety of tissues, bronchial smooth muscle cells, myocardium, and the pituitary gland. There is no significant expression of ET(B) mRNA in vascular smooth muscle cells, and ET(A), thus, plays a primary role in ET-induced vascular contraction. ET(B) mRNA is more widely distributed in various cell types of many tissues. Its prominent expression is seen in glial cells throughout the brain regions, epithelial cells of the choroid plexus, ependymal cells lining the ventricle, myocardium, endothelial cells of glomeruli, and epithelial cells of the thin segments of Henle's loops. Our investigation demonstrates that the mRNAs for the two subtypes of rat ET receptors show specialized expression patterns of cell types in both brain and peripheral tissues.","lang":"eng"}],"extern":"1"},{"publist_id":"4415","oa_version":"Published Version","date_created":"2018-12-11T11:57:57Z","publisher":"Wiley-Blackwell","title":"Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat","publication":"Journal of Comparative Neurology","extern":"1","abstract":[{"lang":"eng","text":"Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1), which is linked to phosphoinositide (PI) hydrolysis, was investigated in adult and developing rat central nervous system (CNS) by in situ hybridization. Transcripts of mGluR1 were specifically localized to neurons and widely distributed throughout the adult rat brain. Most intensely labeled neurons were Purkinje cells of the cerebellum, mitral and tufted cells of the olfactory bulb, and neurons in the hippocampus, lateral septum, thalamus, globus pallidus, entopeduncular nucleus, ventral pallidum, magnocellular preoptic nucleus, substantia nigra, and dorsal cochlear nucleus. Moderately labeled neurons were seen in high density in the dentate gyrus, striatum, islands of Calleja, superficial layers of the retrosplenial, cingulate and entorhinal cortices, mammillary nuclei, red nucleus, and superior colliculus. In the developing rat brain, the level of mGluR1 expression gradually increased during early postnatal days in accordance with the maturation of neuronal elements. These results show prominent expression of mGluR1 in the major targets of putative glutamatergic pathways and unique distribution pattern of mGluR1 distinct from those reported for ionotropic subtypes of glutamate receptors, suggesting specific roles of mGluR1 in the glutamatergic system."}],"year":"1992","_id":"2486","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"121 - 135","volume":322,"publication_identifier":{"issn":["0021-9967"]},"citation":{"apa":"Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1992). Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903220110\">https://doi.org/10.1002/cne.903220110</a>","chicago":"Shigemoto, Ryuichi, Shigetada Nakanishi, and Noboru Mizuno. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1992. <a href=\"https://doi.org/10.1002/cne.903220110\">https://doi.org/10.1002/cne.903220110</a>.","ieee":"R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat,” <i>Journal of Comparative Neurology</i>, vol. 322, no. 1. Wiley-Blackwell, pp. 121–135, 1992.","mla":"Shigemoto, Ryuichi, et al. “Distribution of the MRNA for a Metabotropic Glutamate Receptor (MGluR1) in the Central Nervous System: An in Situ Hybridization Study in Adult and Developing Rat.” <i>Journal of Comparative Neurology</i>, vol. 322, no. 1, Wiley-Blackwell, 1992, pp. 121–35, doi:<a href=\"https://doi.org/10.1002/cne.903220110\">10.1002/cne.903220110</a>.","ista":"Shigemoto R, Nakanishi S, Mizuno N. 1992. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. Journal of Comparative Neurology. 322(1), 121–135.","short":"R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 322 (1992) 121–135.","ama":"Shigemoto R, Nakanishi S, Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat. <i>Journal of Comparative Neurology</i>. 1992;322(1):121-135. doi:<a href=\"https://doi.org/10.1002/cne.903220110\">10.1002/cne.903220110</a>"},"article_type":"original","external_id":{"pmid":["1430307"]},"issue":"1","acknowledgement":"We are grateful to Mr.  Akira Uesugi for photographic help. This work was supported in part by research grants from Senri Life Science Foundation and the Ministry of Education, Science and Culture of Japan.","status":"public","quality_controlled":"1","scopus_import":"1","date_updated":"2022-03-21T09:41:37Z","doi":"10.1002/cne.903220110","article_processing_charge":"No","date_published":"1992-08-01T00:00:00Z","author":[{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"publication_status":"published","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903220110"}],"intvolume":"       322","language":[{"iso":"eng"}],"month":"08","day":"01","pmid":1},{"date_published":"1992-09-14T00:00:00Z","author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Ohishi, Hitoshi","first_name":"Hitoshi","last_name":"Ohishi"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"article_processing_charge":"No","doi":"10.1016/0304-3940(92)90756-W","date_updated":"2022-03-18T13:15:02Z","scopus_import":"1","quality_controlled":"1","pmid":1,"day":"14","month":"09","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/030439409290756W"}],"intvolume":"       144","publication_status":"published","abstract":[{"lang":"eng","text":"The distribution of NMDA receptor (NMDAR1) on neurons in the peripheral ganglia was examined in the adult rat by in situ hybridization. NMDAR1 mRNA was expressed in all neurons in the sensory and autonomic ganglia examined; in the dorsal root, trigeminal, nodose, superior cervical, and sphenopalatine ganglia. Possible roles of the NMDA receptor on the sensory and autonomic ganglion neurons are discussed."}],"extern":"1","publication":"Neuroscience Letters","title":"Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons","publisher":"Elsevier","date_created":"2018-12-11T11:58:13Z","oa_version":"None","publist_id":"4368","acknowledgement":"The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from the Ministry of Education, Science and Culture of Japan.","status":"public","issue":"1-2","external_id":{"pmid":["1436707"]},"article_type":"original","citation":{"ama":"Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. <i>Neuroscience Letters</i>. 1992;144(1-2):229-232. doi:<a href=\"https://doi.org/10.1016/0304-3940(92)90756-W\">10.1016/0304-3940(92)90756-W</a>","ista":"Shigemoto R, Ohishi H, Nakanishi S, Mizuno N. 1992. Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. Neuroscience Letters. 144(1–2), 229–232.","mla":"Shigemoto, Ryuichi, et al. “Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” <i>Neuroscience Letters</i>, vol. 144, no. 1–2, Elsevier, 1992, pp. 229–32, doi:<a href=\"https://doi.org/10.1016/0304-3940(92)90756-W\">10.1016/0304-3940(92)90756-W</a>.","short":"R. Shigemoto, H. Ohishi, S. Nakanishi, N. Mizuno, Neuroscience Letters 144 (1992) 229–232.","chicago":"Shigemoto, Ryuichi, Hitoshi Ohishi, Shigetada Nakanishi, and Noboru Mizuno. “Expression of the MRNA for the Rat NMDA Receptor (NMDAR1) in the Sensory and Autonomic Ganglion Neurons.” <i>Neuroscience Letters</i>. Elsevier, 1992. <a href=\"https://doi.org/10.1016/0304-3940(92)90756-W\">https://doi.org/10.1016/0304-3940(92)90756-W</a>.","ieee":"R. Shigemoto, H. Ohishi, S. Nakanishi, and N. Mizuno, “Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons,” <i>Neuroscience Letters</i>, vol. 144, no. 1–2. Elsevier, pp. 229–232, 1992.","apa":"Shigemoto, R., Ohishi, H., Nakanishi, S., &#38; Mizuno, N. (1992). Expression of the mRNA for the rat NMDA receptor (NMDAR1) in the sensory and autonomic ganglion neurons. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(92)90756-W\">https://doi.org/10.1016/0304-3940(92)90756-W</a>"},"publication_identifier":{"issn":["0304-3940"]},"volume":144,"page":"229 - 232","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"2531","year":"1992"},{"volume":52,"page":"3972 - 3979","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"2532","year":"1992","acknowledgement":"We wish to acknowledge generous donations of human samples by the following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto, Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato for their expert technical assistance. Supported in part by Grants in Aids for Basic Research on Radiation Therapy (03151034) and Special Project Research on Cancer Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda Medical Foundation, and by Monbusho International Scientific Research: Joint Research.","status":"public","issue":"14","external_id":{"pmid":["1617673"]},"article_type":"original","citation":{"apa":"Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi, H. (1992). Distribution of the glucose transporters in human brain tumors. <i>Cancer Research</i>. American Association for Cancer Research.","chicago":"Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution of the Glucose Transporters in Human Brain Tumors.” <i>Cancer Research</i>. American Association for Cancer Research, 1992.","ieee":"T. Nishioka <i>et al.</i>, “Distribution of the glucose transporters in human brain tumors,” <i>Cancer Research</i>, vol. 52, no. 14. American Association for Cancer Research, pp. 3972–3979, 1992.","mla":"Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human Brain Tumors.” <i>Cancer Research</i>, vol. 52, no. 14, American Association for Cancer Research, 1992, pp. 3972–79.","short":"T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura, R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979.","ista":"Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors. Cancer Research. 52(14), 3972–3979.","ama":"Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters in human brain tumors. <i>Cancer Research</i>. 1992;52(14):3972-3979."},"publication_identifier":{"issn":["0008-5472"]},"publication":"Cancer Research","title":"Distribution of the glucose transporters in human brain tumors","publisher":"American Association for Cancer Research","date_created":"2018-12-11T11:58:13Z","oa_version":"None","publist_id":"4367","abstract":[{"lang":"eng","text":"In the present study, we have investigated the expression of both the erythrocyte-type (GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human brain tumors. In situ hybridization made it possible to localize and semiquantify both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells, while the reverse was the case in all 6 meningiomas. In astrocytomas, for both mRNAs, the density of silver grains over tumor cells was well correlated with the malignancy of the cells. This correlation was, as was also confirmed by Northern blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs was in good accordance with that of both proteins. Our results suggest that the expression of both glucose transporter isoforms may contribute to the maintenance of human brain tumors and that the expression of the GLUT3 isoform may be closely related to the malignant change of astrocytomas and particularly related to the aberrant neovascularization which accompanies glioblastomas."}],"extern":"1","main_file_link":[{"url":"https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human"}],"intvolume":"        52","publication_status":"published","pmid":1,"day":"01","month":"01","language":[{"iso":"eng"}],"author":[{"last_name":"Nishioka","first_name":"Tatsuya","full_name":"Nishioka, Tatsuya"},{"last_name":"Oda","first_name":"Yoshifumi","full_name":"Oda, Yoshifumi"},{"full_name":"Seino, Yutaka","last_name":"Seino","first_name":"Yutaka"},{"full_name":"Yamamoto, Taizo","last_name":"Yamamoto","first_name":"Taizo"},{"last_name":"Inagaki","first_name":"Nobuya","full_name":"Inagaki, Nobuya"},{"full_name":"Yano, Hideki","first_name":"Hideki","last_name":"Yano"},{"first_name":"Hiroo","last_name":"Imura","full_name":"Imura, Hiroo"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"first_name":"Haruhiko","last_name":"Kikuchi","full_name":"Kikuchi, Haruhiko"}],"date_published":"1992-01-01T00:00:00Z","article_processing_charge":"No","date_updated":"2022-03-17T15:38:42Z","scopus_import":"1","quality_controlled":"1"},{"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925818422193","open_access":"1"}],"intvolume":"       267","publication_status":"published","month":"07","language":[{"iso":"eng"}],"pmid":1,"day":"05","scopus_import":"1","quality_controlled":"1","date_published":"1992-07-05T00:00:00Z","author":[{"full_name":"Abe, Takaaki","last_name":"Abe","first_name":"Takaaki"},{"full_name":"Sugihara, Hidemitsu","last_name":"Sugihara","first_name":"Hidemitsu"},{"last_name":"Nawa","first_name":"Hiroyuki","full_name":"Nawa, Hiroyuki"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"}],"article_processing_charge":"No","date_updated":"2022-03-17T15:08:29Z","doi":"10.1016/S0021-9258(18)42219-3","_id":"2533","year":"1992","volume":267,"page":"13361 - 13368","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","citation":{"chicago":"Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1992. <a href=\"https://doi.org/10.1016/S0021-9258(18)42219-3\">https://doi.org/10.1016/S0021-9258(18)42219-3</a>.","ieee":"T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction,” <i>Journal of Biological Chemistry</i>, vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp. 13361–13368, 1992.","apa":"Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1992). Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/S0021-9258(18)42219-3\">https://doi.org/10.1016/S0021-9258(18)42219-3</a>","ama":"Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. <i>Journal of Biological Chemistry</i>. 1992;267(19):13361-13368. doi:<a href=\"https://doi.org/10.1016/S0021-9258(18)42219-3\">10.1016/S0021-9258(18)42219-3</a>","ista":"Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry. 267(19), 13361–13368.","mla":"Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” <i>Journal of Biological Chemistry</i>, vol. 267, no. 19, American Society for Biochemistry and Molecular Biology, 1992, pp. 13361–68, doi:<a href=\"https://doi.org/10.1016/S0021-9258(18)42219-3\">10.1016/S0021-9258(18)42219-3</a>.","short":"T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 267 (1992) 13361–13368."},"publication_identifier":{"issn":["0021-9258"]},"acknowledgement":"We are grateful to Seiji Ito for help of Ca2+ measurements and Akira Uesugi for photographic assistance.","status":"public","oa":1,"issue":"19","article_type":"original","external_id":{"pmid":["1320017"]},"date_created":"2018-12-11T11:58:14Z","oa_version":"Published Version","publist_id":"4366","publication":"Journal of Biological Chemistry","title":"Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction","publisher":"American Society for Biochemistry and Molecular Biology","abstract":[{"text":"A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by the subsequent screening of a rat brain cDNA library. The cloned receptor consists of 1171 amino acid residues and exhibits a structural architecture common to the mGluR family, possessing a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1 among the mGluR members and is coupled to the stimulation of phosphatidylinositol hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity and antagonist responses; the potency rank order of agonists for mGluR5 was determined to be quisqualate &gt; L-glutamate ≥ ibotenate &gt; trans-1-aminocyclopentane-1,3-dicarboxylate. Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed in neuronal cells of the central nervous system and is expressed differently from mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction and pharmacological properties and is expressed in specialized neuronal cells in the central nervous system.","lang":"eng"}],"extern":"1"}]