[{"publication_status":"published","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/222823"}],"volume":40,"article_processing_charge":"No","issue":"3","_id":"3446","abstract":[{"lang":"eng","text":"An effective character recognition procedure implemented on a new type of hardware system and using a new architecture called CNND is proposed. This CNND contains one or more analog cellular neural networks (CNNs) and some digital logic, combining the advantages of the fast analog CNN signal processing and the fast and easy decision capability of digital logic. It is shown that the CNND system can be used for recognition of multifont printed or handwritten characters and could recognize 100,000 char/s with a recognition rate of more than 95%. The more advantage of the system over competing types is that there is not an extra feature extraction procedure implemented in slow hardware"}],"date_published":"1993-03-01T00:00:00Z","scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T14:44:44Z","publication_identifier":{"issn":["1057-7130"]},"article_type":"original","publist_id":"2941","oa_version":"None","year":"1993","publisher":"IEEE","publication":"IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing","quality_controlled":"1","intvolume":"        40","status":"public","page":"223 - 231","month":"03","extern":"1","date_created":"2018-12-11T12:03:22Z","language":[{"iso":"eng"}],"doi":"10.1109/82.222823","citation":{"mla":"Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3, IEEE, 1993, pp. 223–31, doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>.","chicago":"Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE, 1993. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>.","ista":"Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.","ieee":"T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using a dual cellular neural network architecture (CNND),” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3. IEEE, pp. 223–231, 1993.","ama":"Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. 1993;40(3):223-231. doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>","apa":"Sziranyi, T., &#38; Csicsvari, J. L. (1993). High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>","short":"T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing 40 (1993) 223–231."},"title":"High-speed character recognition using a dual cellular neural network architecture (CNND)","day":"01","type":"journal_article","author":[{"full_name":"Sziranyi, Tamas","first_name":"Tamas","last_name":"Sziranyi"},{"last_name":"Csicsvari","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}]},{"publisher":"New York Academy of Sciences","intvolume":"       707","status":"public","quality_controlled":"1","publication":"Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction","page":"126 - 135","series_title":"Annals of the New York Academy of Sciences","date_created":"2018-12-11T12:03:24Z","extern":"1","month":"12","acknowledgement":"I thank Prof. B. Sakmann for generous support and Drs. M. Häusser and A. Villarroel for critically reading the manuscript.","pmid":1,"doi":"10.1111/j.1749-6632.1993.tb38048.x","language":[{"iso":"eng"}],"title":"Glutamate receptors in the central nervous system","citation":{"ieee":"P. M. Jonas, “Glutamate receptors in the central nervous system,” in <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–135.","ista":"Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707, 126–135.","chicago":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, 707:126–35. Annals of the New York Academy of Sciences. New York Academy of Sciences, 1993. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>.","mla":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–35, doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>.","short":"P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy of Sciences, 1993, pp. 126–135.","apa":"Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i> (Vol. 707, pp. 126–135). New York Academy of Sciences. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>","ama":"Jonas PM. Glutamate receptors in the central nervous system. In: <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>. Vol 707. Annals of the New York Academy of Sciences. New York Academy of Sciences; 1993:126-135. doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>"},"alternative_title":["Annals of the New York Academy of Sciences "],"author":[{"first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"}],"type":"book_chapter","day":"20","main_file_link":[{"url":"https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x"}],"publication_status":"published","volume":707,"article_processing_charge":"No","_id":"3451","date_published":"1993-12-20T00:00:00Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T12:35:23Z","external_id":{"pmid":["9729204"]},"scopus_import":"1","oa_version":"None","year":"1993","publist_id":"2936"},{"volume":66,"main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4"}],"publication_status":"published","date_published":"1993-01-01T00:00:00Z","_id":"3452","abstract":[{"lang":"eng","text":"In recent years, considerable progress in our understanding of the molecular events underlying excitatory synaptic transmission has been made. This progress was mainly achieved by technical advances, among them the patch-clamp technique in brain slices (Edwards et al., 1989), fast application of agonists (Franke et al., 1987), and cloning and functional expression of GluR channels of the nonNMDA type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse is located close to the cell soma and should provide almost ideal space-clamp conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application of glutamate on membrane patches isolated from CA3 cell somata suggests that the concentration of glutamate in the synaptic cleft during excitatory synaptic transmission is high (about 1 mM) and that the transmitter remains in the synaptic cleft only briefly (about 1 ms). It seems likely that desensitization influences the peak amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization, from which the glutamate receptor channels recover only slowly, and micromolar ambient glutamate concentrations produce desensitization at equilibrium. From the functional properties of recombinant GluR channels, in situ hybridization data, and patch-clamp experiments on different neuronal and nonneuronal cell types, a picture of the molecular identity of native channels emerges. In neurons of the hippocampus the pharmacological features of these channels were similar to recombinant channels assembled from subunits of the AMPA/kainate subtype which are strongly expressed in these cells. The native channels are characterized by outward rectification of the steady-state I-V and low Ca permeability, similar to recombinant channels containing the GluR-B subunit. This is consistent with the ubiquitous expression of this subunit in hippocampal neurones. In contrast, GluR channels from cerebellar glial cells, which uniquely in the central nervous system lack the expression of GluR-B subunits, show double rectification and high Ca permeability. The results suggest that the native functional nonNMDA glutamate receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype in a cell-specific way, with the functional properties of GluR channels in neurones being dominated by the GluR-B subunit."}],"article_processing_charge":"No","publication_identifier":{"isbn":["978-3-0348-7327-7"]},"scopus_import":"1","external_id":{"pmid":["7505664"]},"date_updated":"2022-03-30T11:46:44Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"1993","oa_version":"None","publist_id":"2935","editor":[{"last_name":"Siemen","first_name":"Detlef","full_name":"Siemen, Detlef"}],"intvolume":"        66","status":"public","publication":"Nonselective cation channels: Pharmacology, Physiology and Biophysics.","quality_controlled":"1","publisher":"Birkhäuser","date_created":"2018-12-11T12:03:24Z","month":"01","extern":"1","page":"61 - 76","doi":"10.1007/978-3-0348-7327-7_4","language":[{"iso":"eng"}],"pmid":1,"author":[{"orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"type":"book_chapter","alternative_title":["EXS"],"day":"01","title":"AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS","citation":{"ieee":"P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS,” in <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i>, vol. 66, D. Siemen, Ed. Birkhäuser, 1993, pp. 61–76.","ista":"Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Nonselective cation channels: Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.","chicago":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” In <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, 66:61–76. Birkhäuser, 1993. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>.","mla":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, vol. 66, Birkhäuser, 1993, pp. 61–76, doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>.","short":"P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology, Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.","apa":"Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i> (Vol. 66, pp. 61–76). Birkhäuser. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>","ama":"Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Siemen D, ed. <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i> Vol 66. Birkhäuser; 1993:61-76. doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>"}},{"intvolume":"         3","status":"public","publication":"Cellular Physiology and Biochemistry","quality_controlled":"1","publisher":"S. Karger AG","date_created":"2018-12-11T12:03:31Z","month":"01","extern":"1","page":"250 - 269","doi":"10.1159/000154691","language":[{"iso":"eng"}],"author":[{"full_name":"Ruppersberg, Peter","first_name":"Peter","last_name":"Ruppersberg"},{"last_name":"Ermler","full_name":"Ermler, Mamfred","first_name":"Mamfred"},{"last_name":"Knopf","first_name":"Martin","full_name":"Knopf, Martin"},{"last_name":"Kues","full_name":"Kues, Wilfried","first_name":"Wilfried"},{"last_name":"Jonas","full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Koenen, Michael","first_name":"Michael","last_name":"Koenen"}],"type":"journal_article","day":"01","title":"Properties of Shaker-homologous potassium channels expressed in the mammalian brain.","citation":{"ieee":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen, “Properties of Shaker-homologous potassium channels expressed in the mammalian brain.,” <i>Cellular Physiology and Biochemistry</i>, vol. 3. S. Karger AG, pp. 250–269, 1993.","ista":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular Physiology and Biochemistry. 3, 250–269.","chicago":"Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>. S. Karger AG, 1993. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>.","mla":"Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>, vol. 3, S. Karger AG, 1993, pp. 250–69, doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>.","short":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular Physiology and Biochemistry 3 (1993) 250–269.","apa":"Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., &#38; Koenen, M. (1993). Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. S. Karger AG. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>","ama":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. 1993;3:250-269. doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>"},"volume":3,"main_file_link":[{"url":"https://www.karger.com/Article/Abstract/154691"}],"publication_status":"published","_id":"3473","date_published":"1993-01-01T00:00:00Z","abstract":[{"lang":"eng","text":"Sixteen different K+ channel subtypes have been cloned from mammalian tissue. Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal channels, they were classified into four corresponding classes Kv1-4. All K+ channels belonging to these classes consist of four subunits with each six hydrophobic segments (S1-S6) and a characteristic structure-function relationship of certain domains in their amino acid sequence. These domains are, the inactivation gate in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic segment (S4), and the pore-region in the H5 segment between S5 and S6. In some functional properties K+ channels cloned from the mammalian brain, however, differ from Drosophila K+ channels. These are pharmacological differences, differences in the threshold of activation and in regulation of inactivation. Part of these differences are important to understand their physiological role in the brain. Based on their functional characteristics the expression pattern of cloned K+ channels in the rat brain can be correlated with the properties of K+ currents measured in central neurones."}],"article_processing_charge":"No","publication_identifier":{"issn":["1015-8987"]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T10:21:04Z","oa_version":"None","year":"1993","article_type":"original","publist_id":"2914"},{"publist_id":"2913","article_type":"original","year":"1993","oa_version":"Published Version","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T09:33:19Z","scopus_import":"1","external_id":{"pmid":["7908327"]},"publication_identifier":{"issn":["0022-3751"]},"_id":"3474","abstract":[{"text":"1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were evoked by extracellular stimulation of the mossy fibre tract. Using the selective blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor-mediated component and a minor NMDA receptor-mediated component with slower time course were distinguished. For the AMPA/kainate receptor-mediated component, the peak current-voltage (I-V) relation was linear, with a reversal potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353 nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude as a function of stimulus intensity showed all-or-none behaviour. The region of low threshold was restricted to a few micrometres. This suggests that extracellular stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0 ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest rise (rise time 0.5 ms or less) could be described by a single exponential function; the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells). 5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation fluctuated between trials. The apparent EPSC peak conductance in normal extracellular solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+ concentration and increasing the Mg2+ concentration reduced the mean peak amplitude in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and the presence of peaks and dips in the autocorrelation function, five of nine EPSC peak amplitude distributions were judged to be quantal.","lang":"eng"}],"date_published":"1993-12-01T00:00:00Z","article_processing_charge":"No","volume":472,"publication_status":"published","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505"}],"oa":1,"day":"01","author":[{"full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804"},{"last_name":"Major","full_name":"Major, Guy","first_name":"Guy"},{"last_name":"Sakmann","first_name":"Bert","full_name":"Sakmann, Bert"}],"type":"journal_article","citation":{"ieee":"P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” <i>Journal of Physiology</i>, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.","ista":"Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology. 472, 615–663.","chicago":"Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>.","mla":"Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>.","short":"P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.","apa":"Jonas, P. M., Major, G., &#38; Sakmann, B. (1993). Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>","ama":"Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. 1993;472:615-663. doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>"},"title":"Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus","language":[{"iso":"eng"}],"doi":"10.1113/jphysiol.1993.sp019965","acknowledgement":"We are indebted to Professor B. Katz for critically reading the manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun for several discussions, for generously providing the source codes of programs for maximum-likelihood fit with sums of Gaussian functions, a routine for calculating the error function and for critically reading the manuscript. We also thank Drs A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser for excellent technical assistance. Part of the project was supported by the Deutsche Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust.","pmid":1,"extern":"1","month":"12","date_created":"2018-12-11T12:03:31Z","page":"615 - 663","quality_controlled":"1","publication":"Journal of Physiology","intvolume":"       472","status":"public","publisher":"Wiley-Blackwell"},{"citation":{"short":"H. Edelsbrunner, in:, Handbook of Convex Geometry, North Holland, 1993, pp. 699–735.","apa":"Edelsbrunner, H. (1993). Geometric algorithms. In <i>Handbook of Convex Geometry</i> (pp. 699–735). North Holland. <a href=\"https://doi.org/10.1016/C2009-0-15705-7\">https://doi.org/10.1016/C2009-0-15705-7</a>","ama":"Edelsbrunner H. Geometric algorithms. In: <i>Handbook of Convex Geometry</i>. North Holland; 1993:699-735. doi:<a href=\"https://doi.org/10.1016/C2009-0-15705-7\">10.1016/C2009-0-15705-7</a>","ista":"Edelsbrunner H. 1993.Geometric algorithms. In: Handbook of Convex Geometry. , 699–735.","ieee":"H. Edelsbrunner, “Geometric algorithms,” in <i>Handbook of Convex Geometry</i>, North Holland, 1993, pp. 699–735.","chicago":"Edelsbrunner, Herbert. “Geometric Algorithms.” In <i>Handbook of Convex Geometry</i>, 699–735. North Holland, 1993. <a href=\"https://doi.org/10.1016/C2009-0-15705-7\">https://doi.org/10.1016/C2009-0-15705-7</a>.","mla":"Edelsbrunner, Herbert. “Geometric Algorithms.” <i>Handbook of Convex Geometry</i>, North Holland, 1993, pp. 699–735, doi:<a href=\"https://doi.org/10.1016/C2009-0-15705-7\">10.1016/C2009-0-15705-7</a>."},"title":"Geometric algorithms","day":"24","publist_id":"2817","type":"book_chapter","author":[{"last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833"}],"year":"1993","oa_version":"None","date_updated":"2022-03-30T09:30:11Z","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"isbn":["978-0-444-89596-7"]},"doi":"10.1016/C2009-0-15705-7","page":"699 - 735","article_processing_charge":"No","month":"08","extern":"1","_id":"3568","date_created":"2018-12-11T12:04:00Z","date_published":"1993-08-24T00:00:00Z","publisher":"North Holland","publication_status":"published","main_file_link":[{"url":"https://www.sciencedirect.com/book/9780444895967/handbook-of-convex-geometry"}],"publication":"Handbook of Convex Geometry","status":"public"},{"date_updated":"2022-03-30T08:46:20Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["978-9810214623"]},"citation":{"short":"H. Edelsbrunner, in:, Current Trends in Theoretical Computer Science, Essays and Tutorials, World Scientific Publishing, 1993, pp. 1–48.","apa":"Edelsbrunner, H. (1993). Computational geometry. In <i>Current Trends in Theoretical Computer Science, Essays and Tutorials</i> (pp. 1–48). World Scientific Publishing.","ama":"Edelsbrunner H. Computational geometry. In: <i>Current Trends in Theoretical Computer Science, Essays and Tutorials</i>. World Scientific Publishing; 1993:1-48.","ista":"Edelsbrunner H. 1993.Computational geometry. In: Current Trends in Theoretical Computer Science, Essays and Tutorials. , 1–48.","ieee":"H. Edelsbrunner, “Computational geometry,” in <i>Current Trends in Theoretical Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993, pp. 1–48.","chicago":"Edelsbrunner, Herbert. “Computational Geometry.” In <i>Current Trends in Theoretical Computer Science, Essays and Tutorials</i>, 1–48. World Scientific Publishing, 1993.","mla":"Edelsbrunner, Herbert. “Computational Geometry.” <i>Current Trends in Theoretical Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993, pp. 1–48."},"title":"Computational geometry","publist_id":"2816","day":"01","oa_version":"None","year":"1993","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner"}],"type":"book_chapter","publisher":"World Scientific Publishing","publication_status":"published","main_file_link":[{"url":"https://books.google.at/books?hl=en&lr=&id=fr_sCgAAQBAJ&oi=fnd&pg=PR5&ots=XAust-LAGl&sig=FQTlA5rrM25y5EZ8ZmrorT7SaMo&redir_esc=y#v=onepage&q&f=false"}],"publication":"Current Trends in Theoretical Computer Science, Essays and Tutorials","status":"public","page":"1 - 48","article_processing_charge":"No","extern":"1","month":"08","date_published":"1993-08-01T00:00:00Z","_id":"3569","date_created":"2018-12-11T12:04:01Z"},{"article_type":"original","publist_id":"2740","year":"1993","oa_version":"None","scopus_import":"1","date_updated":"2022-03-30T08:28:54Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0016-6723"]},"article_processing_charge":"No","issue":"2","date_published":"1993-04-01T00:00:00Z","_id":"3643","abstract":[{"lang":"eng","text":"We investigate the establishment and spread of new adaptive peaks within Wright's ‘shifting balance’. The third phase of the ‘shifting balance’ involves a kind of group selection, since demes in which a superior peak has been established contain more individuals, and so send out more migrants. We assume that population size, N, increases with mean fitness, , according to the exponential relation, . Here, k is a measure of the weakness of density-dependent regulation, and equals the inverse of the regression of log (fitness) on log(N). In the island model, we find that just as with soft selection (k = 0), two distinct types of behaviour exist: group selection makes no qualitative difference. With low numbers of migrants, demes fluctuate almost independently, and only one equilibrium exists. With large numbers of migrants, all the demes evolve towards the same adaptive peak, and so the whole population can move towards one or other of the peaks. Group selection can be understood in terms of an effective mean fitness function. Its main consequence is to increase the effect of selection relative to drift (Ns), and so increase the bias towards the fitter peak. However, this increased bias depends on the ratio between k and the deme size (k/N), and so is very small when density-dependence is reasonably strong."}],"publication_status":"published","main_file_link":[{"url":"https://www.cambridge.org/core/journals/genetics-research/article/group-selection-and-the-shifting-balance/CFDE26EA7125957545F9A0AA37755BC4"}],"volume":61,"citation":{"mla":"Rouhani, Shahin, and Nicholas H. Barton. “Group Selection and the ‘Shifting Balance.’” <i>Genetical Research</i>, vol. 61, no. 2, Cambridge University Press, 1993, pp. 127–36, doi:<a href=\"https://doi.org/10.1017/S0016672300031232\">10.1017/S0016672300031232</a>.","chicago":"Rouhani, Shahin, and Nicholas H Barton. “Group Selection and the ‘Shifting Balance.’” <i>Genetical Research</i>. Cambridge University Press, 1993. <a href=\"https://doi.org/10.1017/S0016672300031232\">https://doi.org/10.1017/S0016672300031232</a>.","ista":"Rouhani S, Barton NH. 1993. Group selection and the ‘shifting balance’. Genetical Research. 61(2), 127–136.","ieee":"S. Rouhani and N. H. Barton, “Group selection and the ‘shifting balance,’” <i>Genetical Research</i>, vol. 61, no. 2. Cambridge University Press, pp. 127–136, 1993.","ama":"Rouhani S, Barton NH. Group selection and the “shifting balance.” <i>Genetical Research</i>. 1993;61(2):127-136. doi:<a href=\"https://doi.org/10.1017/S0016672300031232\">10.1017/S0016672300031232</a>","apa":"Rouhani, S., &#38; Barton, N. H. (1993). Group selection and the “shifting balance.” <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672300031232\">https://doi.org/10.1017/S0016672300031232</a>","short":"S. Rouhani, N.H. Barton, Genetical Research 61 (1993) 127–136."},"title":"Group selection and the 'shifting balance'","day":"01","type":"journal_article","author":[{"first_name":"Shahin","full_name":"Rouhani, Shahin","last_name":"Rouhani"},{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"}],"acknowledgement":"This work was supported by the Darwin Trust, by a Science and Engineering Research Council grant (GR/E/08507), and by an SERC Visiting Fellowship to S.Rouhani. ","language":[{"iso":"eng"}],"doi":"10.1017/S0016672300031232","page":"127 - 136","month":"04","extern":"1","date_created":"2018-12-11T12:04:24Z","publisher":"Cambridge University Press","publication":"Genetical Research","quality_controlled":"1","status":"public","intvolume":"        61"},{"issue":"1","article_processing_charge":"No","date_published":"1993-02-01T00:00:00Z","_id":"3644","abstract":[{"lang":"eng","text":"Wright proposed that there is a ' shifting balance' between selection within demes, random drift, and selection between demes at different 'adaptive peaks'. We investigate the establishment and spread of new adaptive peaks, considering a chromosome rearrangement, and a polygenic character under disruptive selection. When the number of migrants (Nm) is small, demes fluctuate independently, with a bias towards the fitter peak. When Nm is large, the whole population can\r\nmove to one of two stable equilibria, and so can be trapped near the lower peak. These two regimes are separated by a sharp transition at a critical Nm of order 1. Just below this critical point, adaptation is most efficient, since the shifting balance greatly increases the proportion of demes that reach the global optimum. This is so even if one peak is only slightly fitter than the other (AWx \\/N), and for both strong and weak selection (Ns <§ 1 or Ns > 1). Provided that Nm\r\nvaries sufficiently gradually from place to place, the fitter peak can be established in regions where Nm « 1, and can then spread through the rest of the range. Our analysis confirms Wright's argument that if selection, migration and drift are of the same order, the ' shifting balance' leads to efficient evolution towards the global optimum."}],"main_file_link":[{"url":"https://www.cambridge.org/core/journals/genetics-research/article/adaptation-and-the-shifting-balance/2E15452B3AFCA97E77743E0C7E108064"}],"publication_status":"published","volume":61,"year":"1993","oa_version":"None","publist_id":"2739","article_type":"original","publication_identifier":{"issn":["0016-6723"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T08:18:58Z","scopus_import":"1","page":"57 - 74","date_created":"2018-12-11T12:04:24Z","extern":"1","month":"02","publisher":"Cambridge University Press","status":"public","intvolume":"        61","quality_controlled":"1","publication":"Genetical Research","title":"Adaptation and the 'shifting balance'","citation":{"ama":"Barton NH, Rouhani S. Adaptation and the “shifting balance.” <i>Genetical Research</i>. 1993;61(1):57-74. doi:<a href=\"https://doi.org/10.1017/S0016672300031098 \">10.1017/S0016672300031098 </a>","apa":"Barton, N. H., &#38; Rouhani, S. (1993). Adaptation and the “shifting balance.” <i>Genetical Research</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0016672300031098 \">https://doi.org/10.1017/S0016672300031098 </a>","short":"N.H. Barton, S. Rouhani, Genetical Research 61 (1993) 57–74.","mla":"Barton, Nicholas H., and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’” <i>Genetical Research</i>, vol. 61, no. 1, Cambridge University Press, 1993, pp. 57–74, doi:<a href=\"https://doi.org/10.1017/S0016672300031098 \">10.1017/S0016672300031098 </a>.","chicago":"Barton, Nicholas H, and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’” <i>Genetical Research</i>. Cambridge University Press, 1993. <a href=\"https://doi.org/10.1017/S0016672300031098 \">https://doi.org/10.1017/S0016672300031098 </a>.","ieee":"N. H. Barton and S. Rouhani, “Adaptation and the ‘shifting balance,’” <i>Genetical Research</i>, vol. 61, no. 1. Cambridge University Press, pp. 57–74, 1993.","ista":"Barton NH, Rouhani S. 1993. Adaptation and the ‘shifting balance’. Genetical Research. 61(1), 57–74."},"author":[{"last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Rouhani","first_name":"Shahin","full_name":"Rouhani, Shahin"}],"type":"journal_article","day":"01","doi":"10.1017/S0016672300031098 ","language":[{"iso":"eng"}]},{"date_created":"2018-12-11T12:06:34Z","extern":"1","month":"12","page":"1286 - 1302","status":"public","intvolume":"        22","quality_controlled":"1","publication":"SIAM Journal on Computing","publisher":"SIAM","author":[{"first_name":"Bernard","full_name":"Chazelle, Bernard","last_name":"Chazelle"},{"orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner"},{"first_name":"Leonidas","full_name":"Guibas, Leonidas","last_name":"Guibas"},{"last_name":"Sharir","full_name":"Sharir, Micha","first_name":"Micha"},{"full_name":"Snoeyink, Jack","first_name":"Jack","last_name":"Snoeyink"}],"type":"journal_article","day":"01","title":"Computing a face in an arrangement of line segments and related problems","citation":{"mla":"Chazelle, Bernard, et al. “Computing a Face in an Arrangement of Line Segments and Related Problems.” <i>SIAM Journal on Computing</i>, vol. 22, no. 6, SIAM, 1993, pp. 1286–302, doi:<a href=\"https://doi.org/10.1137/0222077 \">10.1137/0222077 </a>.","ieee":"B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Snoeyink, “Computing a face in an arrangement of line segments and related problems,” <i>SIAM Journal on Computing</i>, vol. 22, no. 6. SIAM, pp. 1286–1302, 1993.","ista":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. 1993. Computing a face in an arrangement of line segments and related problems. SIAM Journal on Computing. 22(6), 1286–1302.","chicago":"Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir, and Jack Snoeyink. “Computing a Face in an Arrangement of Line Segments and Related Problems.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href=\"https://doi.org/10.1137/0222077 \">https://doi.org/10.1137/0222077 </a>.","apa":"Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., &#38; Snoeyink, J. (1993). Computing a face in an arrangement of line segments and related problems. <i>SIAM Journal on Computing</i>. SIAM. <a href=\"https://doi.org/10.1137/0222077 \">https://doi.org/10.1137/0222077 </a>","ama":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. Computing a face in an arrangement of line segments and related problems. <i>SIAM Journal on Computing</i>. 1993;22(6):1286-1302. doi:<a href=\"https://doi.org/10.1137/0222077 \">10.1137/0222077 </a>","short":"B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Snoeyink, SIAM Journal on Computing 22 (1993) 1286–1302."},"doi":"10.1137/0222077 ","language":[{"iso":"eng"}],"acknowledgement":"The authors wish to express their gratitude for the generous support and hospitality of the DEC Palo Alto Systems Research Center.","abstract":[{"text":"This paper presents a randomized incremental algorithm for computing a single face in an arrangement of n line segments in the plane that is fairly simple to implement. The expected running time of the algorithm is O(nα(n)log n). The analysis of the algorithm uses a novel approach that generalizes and extends the Clarkson-Shor analysis technique [in Discrete Comput. Geom., 4(1989), pp. 387-421]. A few extensions of the technique, obtaining efficient randomized incremental algorithms for constructing the entire arrangement of a collection of line segments and for computing a single face in an arrangement of Jordan arcs are also presented.","lang":"eng"}],"_id":"4036","date_published":"1993-12-01T00:00:00Z","issue":"6","article_processing_charge":"No","volume":22,"main_file_link":[{"url":"https://epubs.siam.org/doi/10.1137/0222077"}],"publication_status":"published","oa_version":"None","year":"1993","publist_id":"2087","article_type":"original","publication_identifier":{"issn":["0097-5397"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T08:07:21Z","scopus_import":"1"},{"_id":"4040","date_published":"1993-12-01T00:00:00Z","abstract":[{"text":"A plane geometric graph C in ℝ2 conforms to another such graph G if each edge of G is the union of some edges of C. It is proved that, for every G with n vertices and m edges, there is a completion of a Delaunay triangulation of O(m2 n) points that conforms to G. The algorithm that constructs the points is also described.","lang":"eng"}],"article_processing_charge":"No","issue":"1","volume":10,"main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573974"}],"publication_status":"published","oa_version":"None","year":"1993","article_type":"original","publist_id":"2084","publication_identifier":{"issn":["0179-5376"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-28T14:58:16Z","date_created":"2018-12-11T12:06:35Z","month":"12","extern":"1","page":"197 - 213","intvolume":"        10","status":"public","publication":"Discrete & Computational Geometry","quality_controlled":"1","publisher":"Springer","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert"},{"full_name":"Tan, Tiow","first_name":"Tiow","last_name":"Tan"}],"type":"journal_article","day":"01","title":"An upper bound for conforming Delaunay triangulations","citation":{"ama":"Edelsbrunner H, Tan T. An upper bound for conforming Delaunay triangulations. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):197-213. doi:<a href=\"https://doi.org/10.1007/BF02573974\">10.1007/BF02573974</a>","apa":"Edelsbrunner, H., &#38; Tan, T. (1993). An upper bound for conforming Delaunay triangulations. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573974\">https://doi.org/10.1007/BF02573974</a>","short":"H. Edelsbrunner, T. Tan, Discrete &#38; Computational Geometry 10 (1993) 197–213.","mla":"Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay Triangulations.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 197–213, doi:<a href=\"https://doi.org/10.1007/BF02573974\">10.1007/BF02573974</a>.","chicago":"Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay Triangulations.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573974\">https://doi.org/10.1007/BF02573974</a>.","ieee":"H. Edelsbrunner and T. Tan, “An upper bound for conforming Delaunay triangulations,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 197–213, 1993.","ista":"Edelsbrunner H, Tan T. 1993. An upper bound for conforming Delaunay triangulations. Discrete &#38; Computational Geometry. 10(1), 197–213."},"doi":"10.1007/BF02573974","language":[{"iso":"eng"}],"acknowledgement":"Research of the first author is supported by the National Science Foundation under Grant CCR-8921421 and under the Alan T. Waterman award, Grant CCR-9118874. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. Work of the second author was conducted while he was on study leave at the University of Illinois. "},{"title":"On the zone theorem for hyperplane arrangements","citation":{"short":"H. Edelsbrunner, R. Seidel, M. Sharir, SIAM Journal on Computing 22 (1993) 418–429.","ama":"Edelsbrunner H, Seidel R, Sharir M. On the zone theorem for hyperplane arrangements. <i>SIAM Journal on Computing</i>. 1993;22(2):418-429. doi:<a href=\"https://doi.org/10.1137/0222031\">10.1137/0222031</a>","apa":"Edelsbrunner, H., Seidel, R., &#38; Sharir, M. (1993). On the zone theorem for hyperplane arrangements. <i>SIAM Journal on Computing</i>. SIAM. <a href=\"https://doi.org/10.1137/0222031\">https://doi.org/10.1137/0222031</a>","chicago":"Edelsbrunner, Herbert, Raimund Seidel, and Micha Sharir. “On the Zone Theorem for Hyperplane Arrangements.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href=\"https://doi.org/10.1137/0222031\">https://doi.org/10.1137/0222031</a>.","ieee":"H. Edelsbrunner, R. Seidel, and M. Sharir, “On the zone theorem for hyperplane arrangements,” <i>SIAM Journal on Computing</i>, vol. 22, no. 2. SIAM, pp. 418–429, 1993.","ista":"Edelsbrunner H, Seidel R, Sharir M. 1993. On the zone theorem for hyperplane arrangements. SIAM Journal on Computing. 22(2), 418–429.","mla":"Edelsbrunner, Herbert, et al. “On the Zone Theorem for Hyperplane Arrangements.” <i>SIAM Journal on Computing</i>, vol. 22, no. 2, SIAM, 1993, pp. 418–29, doi:<a href=\"https://doi.org/10.1137/0222031\">10.1137/0222031</a>."},"author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert"},{"full_name":"Seidel, Raimund","first_name":"Raimund","last_name":"Seidel"},{"last_name":"Sharir","first_name":"Micha","full_name":"Sharir, Micha"}],"type":"journal_article","day":"01","acknowledgement":"National Science Foundation under grant CCR-89- 21421.","doi":"10.1137/0222031","language":[{"iso":"eng"}],"page":"418 - 429","date_created":"2018-12-11T12:06:35Z","month":"04","extern":"1","publisher":"SIAM","intvolume":"        22","status":"public","publication":"SIAM Journal on Computing","quality_controlled":"1","oa_version":"None","year":"1993","article_type":"original","publist_id":"2085","publication_identifier":{"issn":["0097-5397"]},"scopus_import":"1","date_updated":"2022-03-29T13:25:02Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","issue":"2","_id":"4041","abstract":[{"lang":"eng","text":"The zone theorem for an arrangement of n hyperplanes in d-dimensional real space says that the total number of faces bounding the cells intersected by another hyperplane is O(n(d-1)). This result is the basis of a time-optimal incremental algorithm that constructs a hyperplane arrangement and has a host of other algorithmic and combinatorial applications. Unfortunately, the original proof of the zone theorem, for d greater-than-or-equal-to 3, turned out to contain a serious and irreparable error. This paper presents a new proof of the theorem. The proof is based on an inductive argument, which also applies in the case of pseudohyperplane arrangements. The fallacies of the old proof along with some ways of partially saving that approach are briefly discussed."}],"date_published":"1993-04-01T00:00:00Z","main_file_link":[{"url":"https://epubs.siam.org/doi/10.1137/0222031"}],"publication_status":"published","volume":22},{"oa_version":"None","year":"1993","publist_id":"2086","article_type":"original","publication_identifier":{"issn":["0097-5397"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T07:43:13Z","scopus_import":"1","issue":"3","article_processing_charge":"No","_id":"4042","date_published":"1993-06-01T00:00:00Z","abstract":[{"lang":"eng","text":"It is shown that a triangulation of a set of n points in the plane that minimizes the maximum edge length can be computed in time 0(n2). The algorithm is reasonably easy to implement and is based on the theorem that there is a triangulation with minmax edge length that contains the relative neighborhood graph of the points as a subgraph. With minor modifications the algorithm works for arbitrary normed metrics."}],"main_file_link":[{"url":"https://epubs.siam.org/doi/10.1137/0222036"}],"publication_status":"published","volume":22,"title":"A quadratic time algorithm for the minmax length triangulation","citation":{"mla":"Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the Minmax Length Triangulation.” <i>SIAM Journal on Computing</i>, vol. 22, no. 3, SIAM, 1993, pp. 527–51, doi:<a href=\"https://doi.org/10.1137/0222036 \">10.1137/0222036 </a>.","chicago":"Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the Minmax Length Triangulation.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href=\"https://doi.org/10.1137/0222036 \">https://doi.org/10.1137/0222036 </a>.","ista":"Edelsbrunner H, Tan T. 1993. A quadratic time algorithm for the minmax length triangulation. SIAM Journal on Computing. 22(3), 527–551.","ieee":"H. Edelsbrunner and T. Tan, “A quadratic time algorithm for the minmax length triangulation,” <i>SIAM Journal on Computing</i>, vol. 22, no. 3. SIAM, pp. 527–551, 1993.","ama":"Edelsbrunner H, Tan T. A quadratic time algorithm for the minmax length triangulation. <i>SIAM Journal on Computing</i>. 1993;22(3):527-551. doi:<a href=\"https://doi.org/10.1137/0222036 \">10.1137/0222036 </a>","apa":"Edelsbrunner, H., &#38; Tan, T. (1993). A quadratic time algorithm for the minmax length triangulation. <i>SIAM Journal on Computing</i>. SIAM. <a href=\"https://doi.org/10.1137/0222036 \">https://doi.org/10.1137/0222036 </a>","short":"H. Edelsbrunner, T. Tan, SIAM Journal on Computing 22 (1993) 527–551."},"author":[{"full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833"},{"first_name":"Tiow","full_name":"Tan, Tiow","last_name":"Tan"}],"type":"journal_article","day":"01","acknowledgement":"The authors thank an anonymous referee for suggestions on the organization of this paper.","doi":"10.1137/0222036 ","language":[{"iso":"eng"}],"page":"527 - 551","date_created":"2018-12-11T12:06:36Z","extern":"1","month":"06","publisher":"SIAM","status":"public","intvolume":"        22","quality_controlled":"1","publication":"SIAM Journal on Computing"},{"volume":10,"main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573962"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Edge insertion iteratively improves a triangulation of a finite point set in ℜ2 by adding a new edge, deleting old edges crossing the new edge, and retriangulating the polygonal regions on either side of the new edge. This paper presents an abstract view of the edge insertion paradigm, and then shows that it gives polynomial-time algorithms for several types of optimal triangulations, including minimizing the maximum slope of a piecewise-linear interpolating surface."}],"_id":"4044","date_published":"1993-12-01T00:00:00Z","article_processing_charge":"No","issue":"1","publication_identifier":{"issn":["0179-5376"]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-28T14:10:59Z","oa_version":"None","year":"1993","article_type":"original","publist_id":"2082","intvolume":"        10","status":"public","publication":"Discrete & Computational Geometry","quality_controlled":"1","publisher":"Springer","date_created":"2018-12-11T12:06:36Z","month":"12","extern":"1","page":"47 - 65","doi":"10.1007/BF02573962","language":[{"iso":"eng"}],"acknowledgement":"The authors thank two anonymous referees for suggestions on improving the style of this paper. The research of the second' author was supported by the National Science Foundation under Grant No. CCR-8921421 and under the Alan T. Waterman award, Grant No. CCR-9118874. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the view of the National Science Foundation. Part of the work was done while the second, third, and fourth authors visited the Xerox Palo Alto Research Center,\r\nand while the fifth author was on study leave at the University of Illinois. ","author":[{"last_name":"Bern","full_name":"Bern, Marshall","first_name":"Marshall"},{"full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Eppstein","first_name":"David","full_name":"Eppstein, David"},{"first_name":"Stephen","full_name":"Mitchell, Stephen","last_name":"Mitchell"},{"full_name":"Tan, Tiow","first_name":"Tiow","last_name":"Tan"}],"type":"journal_article","day":"01","title":"Edge insertion for optimal triangulations","citation":{"short":"M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, T. Tan, Discrete &#38; Computational Geometry 10 (1993) 47–65.","ama":"Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. Edge insertion for optimal triangulations. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):47-65. doi:<a href=\"https://doi.org/10.1007/BF02573962\">10.1007/BF02573962</a>","apa":"Bern, M., Edelsbrunner, H., Eppstein, D., Mitchell, S., &#38; Tan, T. (1993). Edge insertion for optimal triangulations. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573962\">https://doi.org/10.1007/BF02573962</a>","chicago":"Bern, Marshall, Herbert Edelsbrunner, David Eppstein, Stephen Mitchell, and Tiow Tan. “Edge Insertion for Optimal Triangulations.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573962\">https://doi.org/10.1007/BF02573962</a>.","ieee":"M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, and T. Tan, “Edge insertion for optimal triangulations,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 47–65, 1993.","ista":"Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. 1993. Edge insertion for optimal triangulations. Discrete &#38; Computational Geometry. 10(1), 47–65.","mla":"Bern, Marshall, et al. “Edge Insertion for Optimal Triangulations.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 47–65, doi:<a href=\"https://doi.org/10.1007/BF02573962\">10.1007/BF02573962</a>."}},{"publication_identifier":{"issn":["0179-5376"]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-28T14:50:42Z","oa_version":"None","year":"1993","article_type":"original","publist_id":"2083","volume":10,"main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF02573973"}],"publication_status":"published","_id":"4045","abstract":[{"text":"We apply Megiddo's parametric searching technique to several geometric optimization problems and derive significantly improved solutions for them. We obtain, for any fixed ε&gt;0, an O(n1+ε) algorithm for computing the diameter of a point set in 3-space, an O(8/5+ε) algorithm for computing the width of such a set, and on O(n8/5+ε) algorithm for computing the closest pair in a set of n lines in space. All these algorithms are deterministic.","lang":"eng"}],"date_published":"1993-12-01T00:00:00Z","article_processing_charge":"No","issue":"1","doi":"10.1007/BF02573973","language":[{"iso":"eng"}],"acknowledgement":"*Work by Bernard Chazelle was supported by NSF Grant CCR-90-02352. Work by Herbert Edelsbrunner was supported by NSF Grant CCR-89-21421. Work by Leonidas Guibas and Micha Sharir was supported by a grant from the U.S.-Israeli Binational Science Foundation. Work by Micha Sharir was also supported by ONR Grant N00014-90-J-1284, by NSF Grant CCR-89-01484, and by grants from the Fund for Basic Research administered by the Israeli Academy of Sciences, and the G.I.F., the German-Israeli Foundation for Scientific Research and Development.","author":[{"last_name":"Chazelle","first_name":"Bernard","full_name":"Chazelle, Bernard"},{"last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Leonidas","full_name":"Guibas, Leonidas","last_name":"Guibas"},{"first_name":"Micha","full_name":"Sharir, Micha","last_name":"Sharir"}],"type":"journal_article","day":"01","title":"Diameter, width, closest line pair, and parametric searching","citation":{"short":"B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Discrete &#38; Computational Geometry 10 (1993) 183–196.","ama":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M. Diameter, width, closest line pair, and parametric searching. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):183-196. doi:<a href=\"https://doi.org/10.1007/BF02573973\">10.1007/BF02573973</a>","apa":"Chazelle, B., Edelsbrunner, H., Guibas, L., &#38; Sharir, M. (1993). Diameter, width, closest line pair, and parametric searching. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/BF02573973\">https://doi.org/10.1007/BF02573973</a>","chicago":"Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir. “Diameter, Width, Closest Line Pair, and Parametric Searching.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF02573973\">https://doi.org/10.1007/BF02573973</a>.","ista":"Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1993. Diameter, width, closest line pair, and parametric searching. Discrete &#38; Computational Geometry. 10(1), 183–196.","ieee":"B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “Diameter, width, closest line pair, and parametric searching,” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 183–196, 1993.","mla":"Chazelle, Bernard, et al. “Diameter, Width, Closest Line Pair, and Parametric Searching.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 183–96, doi:<a href=\"https://doi.org/10.1007/BF02573973\">10.1007/BF02573973</a>."},"status":"public","intvolume":"        10","publication":"Discrete & Computational Geometry","quality_controlled":"1","publisher":"Springer","date_created":"2018-12-11T12:06:37Z","month":"12","extern":"1","page":"183 - 196"},{"page":"1455 - 1464","date_created":"2018-12-11T12:07:24Z","extern":"1","month":"11","publisher":"Wiley-Blackwell","status":"public","intvolume":"         5","quality_controlled":"1","publication":"European Journal of Neuroscience","title":"Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity","citation":{"short":"D. Lindholm, G. Dechant, C.-P.J. Heisenberg, H. Thoenen, European Journal of Neuroscience 5 (1993) 1455–1464.","ama":"Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. <i>European Journal of Neuroscience</i>. 1993;5(11):1455-1464. doi:<a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">10.1111/j.1460-9568.1993.tb00213.x</a>","apa":"Lindholm, D., Dechant, G., Heisenberg, C.-P. J., &#38; Thoenen, H. (1993). Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. <i>European Journal of Neuroscience</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>","chicago":"Lindholm, Dan, Georg Dechant, Carl-Philipp J Heisenberg, and Hans Thoenen. “Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” <i>European Journal of Neuroscience</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>.","ista":"Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. 1993. Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity. European Journal of Neuroscience. 5(11), 1455–1464.","ieee":"D. Lindholm, G. Dechant, C.-P. J. Heisenberg, and H. Thoenen, “Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate-induced neurotoxicity,” <i>European Journal of Neuroscience</i>, vol. 5, no. 11. Wiley-Blackwell, pp. 1455–1464, 1993.","mla":"Lindholm, Dan, et al. “Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” <i>European Journal of Neuroscience</i>, vol. 5, no. 11, Wiley-Blackwell, 1993, pp. 1455–64, doi:<a href=\"https://doi.org/10.1111/j.1460-9568.1993.tb00213.x\">10.1111/j.1460-9568.1993.tb00213.x</a>."},"type":"journal_article","author":[{"last_name":"Lindholm","full_name":"Lindholm, Dan","first_name":"Dan"},{"full_name":"Dechant, Georg","first_name":"Georg","last_name":"Dechant"},{"orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J"},{"first_name":"Hans","full_name":"Thoenen, Hans","last_name":"Thoenen"}],"day":"01","pmid":1,"doi":"10.1111/j.1460-9568.1993.tb00213.x","language":[{"iso":"eng"}],"issue":"11","article_processing_charge":"No","_id":"4175","date_published":"1993-11-01T00:00:00Z","abstract":[{"text":"We have studied the effects of different neurotrophins on the survival and proliferation of rat cerebellar granule cells in culture. These neurons express trkB and trkC, the putative neuronal receptors for brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) respectively. Binding studies using iodinated BDNF and NT-3 demonstrated that both BDNF and NT-3 bind to the cerebellar granule neurons with a similar affinity of approximately 2 x 10(-9) M. The number of receptors per granule cell was surprisingly high, approximately 30 x 10(-4) and 2 x 10(5) for BDNF and NT-3, respectively. Both NT-3 and BDNF elevated c-fos mRNA in the granule neurons, but only BDNF up-regulated the mRNA encoding the low-affinity neurotrophin receptor (p75). In contrast to NT-3, BDNF acted as a survival factor for the granule neurons. BDNF also induced sprouting of the granule neurons and significantly protected them against neurotoxicity induced by high (1 mM) glutamate concentrations. Cultured granule neurons also expressed low levels of BDNF mRNA which were increased by kainic acid, a glutamate receptor agonist. Thus, BDNF, but not NT-3, is a survival factor for cultured cerebellar granule neurons and activation of glutamate receptor(s) up-regulates BDNF expression in these cells.","lang":"eng"}],"main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.1993.tb00213.x"}],"publication_status":"published","volume":5,"oa_version":"None","year":"1993","publist_id":"1943","article_type":"original","publication_identifier":{"issn":["0953-816X"]},"date_updated":"2022-03-28T13:33:18Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","scopus_import":"1","external_id":{"pmid":["7904521 "]}},{"article_type":"original","publist_id":"1942","year":"1993","oa_version":"None","scopus_import":"1","external_id":{"pmid":["8320266"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-24T12:59:20Z","publication_identifier":{"issn":["0021-9525"]},"article_processing_charge":"No","issue":"2","date_published":"1993-07-15T00:00:00Z","_id":"4177","abstract":[{"text":"Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation.","lang":"eng"}],"publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119654/"}],"volume":122,"citation":{"short":"D. Lindholm, E. Castrén, P. Tsoulfas, R. Kolbeck, M. Berzaghi, A. Leingärtner, C.-P.J. Heisenberg, L. Tesarollo, L. Parada, H. Thoenen, Journal of Cell Biology 122 (1993) 443–450.","apa":"Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M., Leingärtner, A., … Thoenen, H. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.122.2.443\">https://doi.org/10.1083/jcb.122.2.443</a>","ama":"Lindholm D, Castrén E, Tsoulfas P, et al. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. <i>Journal of Cell Biology</i>. 1993;122(2):443-450. doi:<a href=\"https://doi.org/10.1083/jcb.122.2.443\">10.1083/jcb.122.2.443</a>","ieee":"D. Lindholm <i>et al.</i>, “Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation,” <i>Journal of Cell Biology</i>, vol. 122, no. 2. Rockefeller University Press, pp. 443–450, 1993.","ista":"Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi M, Leingärtner A, Heisenberg C-PJ, Tesarollo L, Parada L, Thoenen H. 1993. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. Journal of Cell Biology. 122(2), 443–450.","chicago":"Lindholm, Dan, Eero Castrén, Pantelis Tsoulfas, Roland Kolbeck, Maria Berzaghi, Axel Leingärtner, Carl-Philipp J Heisenberg, Lino Tesarollo, Luis Parada, and Hans Thoenen. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 1993. <a href=\"https://doi.org/10.1083/jcb.122.2.443\">https://doi.org/10.1083/jcb.122.2.443</a>.","mla":"Lindholm, Dan, et al. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>, vol. 122, no. 2, Rockefeller University Press, 1993, pp. 443–50, doi:<a href=\"https://doi.org/10.1083/jcb.122.2.443\">10.1083/jcb.122.2.443</a>."},"title":"Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation","day":"15","author":[{"last_name":"Lindholm","first_name":"Dan","full_name":"Lindholm, Dan"},{"last_name":"Castrén","full_name":"Castrén, Eero","first_name":"Eero"},{"full_name":"Tsoulfas, Pantelis","first_name":"Pantelis","last_name":"Tsoulfas"},{"last_name":"Kolbeck","first_name":"Roland","full_name":"Kolbeck, Roland"},{"full_name":"Berzaghi, Maria","first_name":"Maria","last_name":"Berzaghi"},{"last_name":"Leingärtner","first_name":"Axel","full_name":"Leingärtner, Axel"},{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"last_name":"Tesarollo","first_name":"Lino","full_name":"Tesarollo, Lino"},{"first_name":"Luis","full_name":"Parada, Luis","last_name":"Parada"},{"first_name":"Hans","full_name":"Thoenen, Hans","last_name":"Thoenen"}],"type":"journal_article","pmid":1,"acknowledgement":"E. Castrtn is an Alexander von Humboldt fellow. M. Berzaghi is supported by a scholarship from CNPQ, Brasil. L. F. Parada, P. Tsoulfas, and L. Tesarollo were supported by a National Institutes of Health grant. We thank D. Stratmann and K. Angermeyer for skillful technical assistance; I. Hajjar for secretarial work and Dr. R. G~rtner for help with\r\ninducing hypothyroidism; Dr. W. Hunzieker for the calbindin-28 kD eDNA; Dr. M. Fishman for the GAP-43 eDNA; and Dr. Y.-A. Barde for critical comments.","language":[{"iso":"eng"}],"doi":"10.1083/jcb.122.2.443","page":"443 - 450","month":"07","extern":"1","date_created":"2018-12-11T12:07:25Z","publisher":"Rockefeller University Press","publication":"Journal of Cell Biology","quality_controlled":"1","intvolume":"       122","status":"public"},{"publication_identifier":{"issn":["0016-6707"]},"external_id":{"pmid":["8125281 "]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-02T10:00:56Z","oa_version":"None","year":"1993","article_type":"original","publist_id":"1769","main_file_link":[{"url":"https://link.springer.com/article/10.1007/BF01435990"}],"publication_status":"published","volume":91,"article_processing_charge":"No","issue":"1-3","abstract":[{"lang":"eng","text":"Evolutionary explanations of aging (or senescence) fall into two classes. First, organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction or high pre-adult survival. Second, the life history might be depressed below this optimal compromise by the influx of deleterious mutations; since selection against late-acting mutations is weaker, deleterious mutations will impose a greater load on late life. We discuss ways in which these theories might be investigated and distinguished, with reference to experimental work withDrosophila. While genetic correlations between life history traits determine the immediate response to selection, they are hard to measure, and may not reflect the fundamental constraints on life history. Long term selection experiments are more likely to be informative. The third approach of using experimental manipulations suffers from some of the same problems as measures of genetic correlations; however, these two approaches may be fruitful when used together. The experimental results so far suggest that aging inDrosophila has evolved in part as a consequence of selection for an optimal life history, and in part as a result of accumulation of predominantly late-acting deleterious mutations. Quantification of these effects presents a major challenge for the future."}],"_id":"4299","date_published":"1993-01-01T00:00:00Z","pmid":1,"doi":"10.1007/BF01435990","language":[{"iso":"eng"}],"title":"Evolution of aging: Testing the theory using Drosophila","citation":{"short":"L. Partridge, N.H. Barton, Genetica 91 (1993) 89–98.","ama":"Partridge L, Barton NH. Evolution of aging: Testing the theory using Drosophila. <i>Genetica</i>. 1993;91(1-3):89-98. doi:<a href=\"https://doi.org/10.1007/BF01435990\">10.1007/BF01435990</a>","apa":"Partridge, L., &#38; Barton, N. H. (1993). Evolution of aging: Testing the theory using Drosophila. <i>Genetica</i>. Springer. <a href=\"https://doi.org/10.1007/BF01435990\">https://doi.org/10.1007/BF01435990</a>","chicago":"Partridge, Linda, and Nicholas H Barton. “Evolution of Aging: Testing the Theory Using Drosophila.” <i>Genetica</i>. Springer, 1993. <a href=\"https://doi.org/10.1007/BF01435990\">https://doi.org/10.1007/BF01435990</a>.","ieee":"L. Partridge and N. H. Barton, “Evolution of aging: Testing the theory using Drosophila,” <i>Genetica</i>, vol. 91, no. 1–3. Springer, pp. 89–98, 1993.","ista":"Partridge L, Barton NH. 1993. Evolution of aging: Testing the theory using Drosophila. Genetica. 91(1–3), 89–98.","mla":"Partridge, Linda, and Nicholas H. Barton. “Evolution of Aging: Testing the Theory Using Drosophila.” <i>Genetica</i>, vol. 91, no. 1–3, Springer, 1993, pp. 89–98, doi:<a href=\"https://doi.org/10.1007/BF01435990\">10.1007/BF01435990</a>."},"author":[{"last_name":"Partridge","full_name":"Partridge, Linda","first_name":"Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H"}],"type":"journal_article","day":"01","publisher":"Springer","status":"public","intvolume":"        91","publication":"Genetica","quality_controlled":"1","page":"89 - 98","date_created":"2018-12-11T12:08:07Z","month":"01","extern":"1"},{"publication_status":"published","main_file_link":[{"url":"https://www.nature.com/articles/362305a0"}],"volume":362,"article_processing_charge":"No","_id":"4300","date_published":"1993-03-25T00:00:00Z","abstract":[{"lang":"eng","text":"Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge."}],"date_updated":"2022-03-24T12:22:38Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["8455716"]},"publication_identifier":{"issn":["0028-0836"]},"publist_id":"1766","article_type":"original","year":"1993","oa_version":"None","publisher":"Nature Publishing Group","quality_controlled":"1","publication":"Nature","status":"public","intvolume":"       362","page":"305 - 311","extern":"1","month":"03","date_created":"2018-12-11T12:08:07Z","acknowledgement":"We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey. A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful comments and C. Roper for providing the data for Fig. 1. Our work was supported by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.","pmid":1,"language":[{"iso":"eng"}],"doi":"10.1038/362305a0","citation":{"mla":"Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>.","chicago":"Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>.","ista":"Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.","ieee":"L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” <i>Nature</i>, vol. 362. Nature Publishing Group, pp. 305–311, 1993.","ama":"Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. <i>Nature</i>. 1993;362:305-311. doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>","apa":"Partridge, L., &#38; Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>","short":"L. Partridge, N.H. Barton, Nature 362 (1993) 305–311."},"title":"Optimality, mutation and the evolution of ageing","day":"25","type":"journal_article","author":[{"last_name":"Partridge","first_name":"Linda","full_name":"Partridge, Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton"}]},{"title":"Genetic analysis of hybrid zones","editor":[{"full_name":"Harrison, Richard","first_name":"Richard","last_name":"Harrison"}],"citation":{"mla":"Barton, Nicholas H., and Katherine Gale. “Genetic Analysis of Hybrid Zones.” <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison, Oxford University Press, 1993, pp. 13–45, doi:<a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">10.1046/j.1420-9101.1994.7050631.x</a>.","ista":"Barton NH, Gale K. 1993.Genetic analysis of hybrid zones. In: Hybrid zones and the evolutionary process. , 13–45.","ieee":"N. H. Barton and K. Gale, “Genetic analysis of hybrid zones,” in <i>Hybrid zones and the evolutionary process</i>, R. Harrison, Ed. Oxford University Press, 1993, pp. 13–45.","chicago":"Barton, Nicholas H, and Katherine Gale. “Genetic Analysis of Hybrid Zones.” In <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison, 13–45. Oxford University Press, 1993. <a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>.","apa":"Barton, N. H., &#38; Gale, K. (1993). Genetic analysis of hybrid zones. In R. Harrison (Ed.), <i>Hybrid zones and the evolutionary process</i> (pp. 13–45). Oxford University Press. <a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>","ama":"Barton NH, Gale K. Genetic analysis of hybrid zones. In: Harrison R, ed. <i>Hybrid Zones and the Evolutionary Process</i>. Oxford University Press; 1993:13-45. doi:<a href=\"https://doi.org/10.1046/j.1420-9101.1994.7050631.x\">10.1046/j.1420-9101.1994.7050631.x</a>","short":"N.H. Barton, K. Gale, in:, R. Harrison (Ed.), Hybrid Zones and the Evolutionary Process, Oxford University Press, 1993, pp. 13–45."},"author":[{"first_name":"Nicholas H","full_name":"Barton, Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"},{"last_name":"Gale","first_name":"Katherine","full_name":"Gale, Katherine"}],"type":"book_chapter","year":"1993","oa_version":"None","day":"01","publist_id":"1764","publication_identifier":{"isbn":[" 0-19-506917-X"]},"doi":"10.1046/j.1420-9101.1994.7050631.x","language":[{"iso":"eng"}],"date_updated":"2022-03-24T10:36:10Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","page":"13 - 45","date_created":"2018-12-11T12:08:08Z","_id":"4301","date_published":"1993-01-01T00:00:00Z","month":"01","extern":"1","main_file_link":[{"url":"https://books.google.at/books?hl=en&lr=&id=aFJFkVKskYIC&oi=fnd&pg=PA13&ots=MFf0ehNeKK&sig=Yp6VrwzCJRB-v-iOhI7WZw-xf8w&redir_esc=y#v=onepage&q&f=false"}],"publisher":"Oxford University Press","publication_status":"published","status":"public","publication":"Hybrid zones and the evolutionary process","quality_controlled":"1"}]