[{"publisher":"Biomedical Research Foundation","date_updated":"2021-01-12T06:58:10Z","publist_id":"4350","publication_status":"published","month":"01","date_published":"1994-01-01T00:00:00Z","abstract":[{"text":"The induction mechanism of cerebellar long term depression (LTD) has been analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we demonstrated that an increase in postsynaptic Ca together with glutamate application is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells. It has also been shown that one subtype of genetically defined metabotropic glutamate receptor, mGluR1, is involved in the LTD induction. We raised antibodies which specifically recognized mGluR1 and inactivated its function. The antibodies suppressed the LTD induction in the cultured Purkinje cells.","lang":"eng"}],"page":"79 - 81","alternative_title":["Biomedical Research"],"intvolume":"        15","status":"public","volume":15,"title":"Induction mechanism of long term depression in cultured Purkinje neurons","day":"01","year":"1994","conference":{"name":"Unknown (0388-6107)"},"author":[{"first_name":"Tomoo","last_name":"Hirano","full_name":"Hirano, Tomoo"},{"last_name":"Kasono","first_name":"Keizo","full_name":"Kasono, Keizo"},{"orcid":"0000-0001-8761-9444","full_name":"Ryuichi Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"}],"issue":"SUPPL. 1","_id":"2548","type":"conference","extern":1,"citation":{"ama":"Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research Foundation; 1994:79-81.","apa":"Hirano, T., Kasono, K., Shigemoto, R., &#38; Nakanishi, S. (1994). Induction mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81). Presented at the Unknown (0388-6107), Biomedical Research Foundation.","short":"T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research Foundation, 1994, pp. 79–81.","chicago":"Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi. “Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81. Biomedical Research Foundation, 1994.","ista":"Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical Research, vol. 15, 79–81.","ieee":"T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism of long term depression in cultured Purkinje neurons,” presented at the Unknown (0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81.","mla":"Hirano, Tomoo, et al. <i>Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons</i>. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994, pp. 79–81."},"date_created":"2018-12-11T11:58:19Z","quality_controlled":0},{"status":"public","title":"Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat","volume":347,"day":"08","author":[{"full_name":"Nakaya, Yoshifumi","last_name":"Nakaya","first_name":"Yoshifumi"},{"full_name":"Kaneko, Takeshi","first_name":"Takeshi","last_name":"Kaneko"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"type":"journal_article","_id":"2549","issue":"2","article_processing_charge":"No","publication":"Journal of Comparative Neurology","date_created":"2018-12-11T11:58:20Z","oa_version":"None","publisher":"Wiley-Blackwell","publist_id":"4349","date_updated":"2022-06-09T09:25:30Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","month":"09","date_published":"1994-09-08T00:00:00Z","article_type":"original","scopus_import":"1","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903470208"}],"pmid":1,"intvolume":"       347","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9967"]},"year":"1994","acknowledgement":"We are grateful for photographic help of Mr. A. Uesugi and the support of Drs. M. Arakawa, S. Fukuchi, T., Fukuda, R. Hayashi, S. Hayashi, S. Imai, M. Katsurada, Y. Kitani, K. Kumagai, H. Kuroda, T. Kuroda, H. Matsubara, J. Matsuoka, H. Matsushima, M. Nishio, G. Niwa, H. Oda, M. Ohbayashi, S. Ohbayashi, H. Ohtsuka, S. Tamaki,  E. Watanabe, and Y. Yoshino. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas 05248207 and 05267104 and Scientific  Research (B) 05454658 and (C) 05680658 from the Ministry of Education, Science and Culture of Japan. ","extern":"1","citation":{"ieee":"Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat,” <i>Journal of Comparative Neurology</i>, vol. 347, no. 2. Wiley-Blackwell, pp. 249–274, 1994.","ista":"Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. Journal of Comparative Neurology. 347(2), 249–274.","mla":"Nakaya, Yoshifumi, et al. “Immunohistochemical Localization of Substance P Receptor in the Central Nervous System of the Adult Rat.” <i>Journal of Comparative Neurology</i>, vol. 347, no. 2, Wiley-Blackwell, 1994, pp. 249–74, doi:<a href=\"https://doi.org/10.1002/cne.903470208\">10.1002/cne.903470208</a>.","apa":"Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1994). Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903470208\">https://doi.org/10.1002/cne.903470208</a>","short":"Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 347 (1994) 249–274.","chicago":"Nakaya, Yoshifumi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the Central Nervous System of the Adult Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1994. <a href=\"https://doi.org/10.1002/cne.903470208\">https://doi.org/10.1002/cne.903470208</a>.","ama":"Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. <i>Journal of Comparative Neurology</i>. 1994;347(2):249-274. doi:<a href=\"https://doi.org/10.1002/cne.903470208\">10.1002/cne.903470208</a>"},"doi":"10.1002/cne.903470208","quality_controlled":"1","abstract":[{"lang":"eng","text":"In an attempt to reveal the function sites of substance P (SP) in the central nervous system (CNS), the distribution of SP receptor (SPR) was immunocytochemically investigated in adult rat and compared with that of SP- positive fibers. SPR-like immunoreactivity (LI) was mostly localized to neuronal cell bodies and dendrites. Neurons with intense SPR-LI were distributed densely in the cortical amygdaloid nucleus, hilus of the dentate gyrus, locus ceruleus, rostral half of the ambiguus nucleus, and intermediolateral nucleus of the thoracic cord; moderately in the caudatoputamen, nucleus accumbens, olfactory tubercle, median, pontine, and magnus raphe nuclei, laminae I and III of the caudal subnucleus of the spinal trigeminal nucleus, and lamina I of the spinal cord; and sparsely in the cerebral cortex, basal nucleus of Meynert, claustrum, gigantocellular reticular nucleus, and lobules IX and X of the cerebellar vermis. Neurons with weak to moderate SPR-LI were distributed more widely throughout the CNS. The regional patterns of distribution of SPR-LI were not necessarily the same as those of SP-positive fibers. The entopeduncular nucleus, substantia nigra, and lateral part of the interpeduncular nucleus showed intense SP-LI but displayed almost no SPR-LI. Conversely, the hilus of the dentate gyrus, anterodorsal thalamic nucleus, central nucleus of the inferior colliculus, and dorsal tegmental nucleus showed intense to moderate SPR-LI but contained few axons with SP-LI. These findings confirmed the presence of the 'mismatch' problem between SP and SPR localizations. However, the distribution of SPR- LI was quite consistent with that of the SP-binding activity, which has been studied via autoradiography. This indicates that the sites of SPR-LI revealed in the present study represent most, if not all, sites of SP-binding activity."}],"external_id":{"pmid":["7814667"]},"page":"249 - 274"},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"American Society for Biochemistry and Molecular Biology","publist_id":"4348","date_updated":"2022-06-08T15:11:44Z","month":"01","date_published":"1994-01-14T00:00:00Z","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925817422472?via%3Dihub","open_access":"1"}],"volume":269,"title":"Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction","status":"public","day":"14","author":[{"first_name":"Naoyuki","last_name":"Okamoto","full_name":"Okamoto, Naoyuki"},{"last_name":"Hori","first_name":"Seiji","full_name":"Hori, Seiji"},{"full_name":"Akazawa, Chihiro","last_name":"Akazawa","first_name":"Chihiro"},{"first_name":"Yasunori","last_name":"Hayashi","full_name":"Hayashi, Yasunori"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"date_created":"2018-12-11T11:58:20Z","oa_version":"None","_id":"2550","issue":"2","type":"journal_article","article_processing_charge":"No","publication":"Journal of Biological Chemistry","oa":1,"abstract":[{"lang":"eng","text":"A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic receptor (mGluR) family and by the subsequent screening of a rat forebrain cDNA library. The cloned mGluR7 subtype consists of 915 amino acid residues and exhibits a structural architecture common to the mGluR family with a large extracellular domain preceding the seven putative membrane-spanning domains. mGluR7 shows the highest sequence similarity to mGluR4 and mGluR6 among the members of the mGluR family. Similar to mGluR4 and mGluR6, mGluR7 inhibits forskolin- stimulated cyclic AMP accumulation in response to agonist interaction and potently reacts with L-2-amino-4-phosphonobutyrate and L-serine-O-phosphate in Chinese hamster ovary cells transfected with the cloned cDNA. RNA blot and in situ hybridization analyses of mGluR7 mRNA indicated that it is widely expressed in many neuronal cells of the central nervous system and is thus different from the more limitedly expressed mGluR4 or mGluR6 mRNA. mGluR7 together with mGluR4 thus corresponds to the putative L-2-amino-4- phosphonobutyrate receptor which plays an important role in modulation of glutamate transmission in the central nervous system."}],"page":"1231 - 1236","external_id":{"pmid":["8288585"]},"pmid":1,"intvolume":"       269","year":"1994","language":[{"iso":"eng"}],"acknowledgement":"We are grateful to Akira Uesugi for photographic assistance.","doi":"10.1016/S0021-9258(17)42247-2","citation":{"ista":"Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S. 1994. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Journal of Biological Chemistry. 269(2), 1231–1236.","ieee":"N. Okamoto <i>et al.</i>, “Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction,” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2. American Society for Biochemistry and Molecular Biology, pp. 1231–1236, 1994.","mla":"Okamoto, Naoyuki, et al. “Molecular Characterization of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2, American Society for Biochemistry and Molecular Biology, 1994, pp. 1231–36, doi:<a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">10.1016/S0021-9258(17)42247-2</a>.","apa":"Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1994). Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">https://doi.org/10.1016/S0021-9258(17)42247-2</a>","short":"N. Okamoto, S. Hori, C. Akazawa, Y. Hayashi, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 269 (1994) 1231–1236.","chicago":"Okamoto, Naoyuki, Seiji Hori, Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1994. <a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">https://doi.org/10.1016/S0021-9258(17)42247-2</a>.","ama":"Okamoto N, Hori S, Akazawa C, et al. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. <i>Journal of Biological Chemistry</i>. 1994;269(2):1231-1236. doi:<a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">10.1016/S0021-9258(17)42247-2</a>"},"quality_controlled":"1","extern":"1"},{"quality_controlled":"1","doi":"10.1016/0304-3940(94)90602-5","citation":{"apa":"Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1994). Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">https://doi.org/10.1016/0304-3940(94)90602-5</a>","short":"C. Akazawa, H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience Letters 171 (1994) 52–54.","chicago":"Akazawa, Chihiro, Hitoshi Ohishi, Yoshiaki Nakajima, Naoyuki Okamoto, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Expression of MRNAs of L-AP4-Sensitive Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” <i>Neuroscience Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">https://doi.org/10.1016/0304-3940(94)90602-5</a>.","ieee":"C. Akazawa <i>et al.</i>, “Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina,” <i>Neuroscience Letters</i>, vol. 171, no. 1–2. Elsevier, pp. 52–54, 1994.","ista":"Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno N. 1994. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171(1–2), 52–54.","mla":"Akazawa, Chihiro, et al. “Expression of MRNAs of L-AP4-Sensitive Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” <i>Neuroscience Letters</i>, vol. 171, no. 1–2, Elsevier, 1994, pp. 52–54, doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">10.1016/0304-3940(94)90602-5</a>.","ama":"Akazawa C, Ohishi H, Nakajima Y, et al. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. <i>Neuroscience Letters</i>. 1994;171(1-2):52-54. doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">10.1016/0304-3940(94)90602-5</a>"},"extern":"1","acknowledgement":"The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from the Ministry of Education, Science and Culture of Japan.","year":"1994","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0304-3940"]},"intvolume":"       171","pmid":1,"page":"52 - 54","external_id":{"pmid":["8084499"]},"abstract":[{"text":"Expression patterns of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7 mRNAs were quite different from that of mGluR6 mRNA which was expressed at the outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell bodies of the ganglion cells, but not in the inner or outer nuclear layer. The expression of mGluR7 mRNA was observed throughout the entire region of the inner nuclear layer and on the cell bodies of the ganglion cells.","lang":"eng"}],"date_created":"2018-12-11T11:58:21Z","oa_version":"None","publication":"Neuroscience Letters","article_processing_charge":"No","_id":"2551","issue":"1-2","type":"journal_article","author":[{"full_name":"Akazawa, Chihiro","first_name":"Chihiro","last_name":"Akazawa"},{"first_name":"Hitoshi","last_name":"Ohishi","full_name":"Ohishi, Hitoshi"},{"last_name":"Nakajima","first_name":"Yoshiaki","full_name":"Nakajima, Yoshiaki"},{"last_name":"Okamoto","first_name":"Naoyuki","full_name":"Okamoto, Naoyuki"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"day":"25","volume":171,"title":"Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina","status":"public","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394094906025?via%3Dihub"}],"scopus_import":"1","article_type":"original","date_published":"1994-04-25T00:00:00Z","month":"04","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-08T14:02:11Z","publist_id":"4346","publisher":"Elsevier"},{"acknowledgement":"The authors are grateful for photographic help of Mr. Akira Uesugi.","extern":"1","quality_controlled":"1","citation":{"ama":"Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. <i>Neuroscience Letters</i>. 1994;166(2):135-138. doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">10.1016/0304-3940(94)90469-3</a>","mla":"Ogawa Meguro, Reiko, et al. “Immunohistochemical Localization of Substance P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>, vol. 166, no. 2, Elsevier, 1994, pp. 135–38, doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">10.1016/0304-3940(94)90469-3</a>.","ista":"Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. 1994. Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. Neuroscience Letters. 166(2), 135–138.","ieee":"R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, and N. Mizuno, “Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat,” <i>Neuroscience Letters</i>, vol. 166, no. 2. Elsevier, pp. 135–138, 1994.","chicago":"Ogawa Meguro, Reiko, Ryuichi Shigemoto, Kazuo Itoh, Akira Konishi, and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">https://doi.org/10.1016/0304-3940(94)90469-3</a>.","short":"R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, N. Mizuno, Neuroscience Letters 166 (1994) 135–138.","apa":"Ogawa Meguro, R., Shigemoto, R., Itoh, K., Konishi, A., &#38; Mizuno, N. (1994). Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">https://doi.org/10.1016/0304-3940(94)90469-3</a>"},"doi":"10.1016/0304-3940(94)90469-3","intvolume":"       166","pmid":1,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0304-3940"]},"year":"1994","external_id":{"pmid":["8177489"]},"page":"135 - 138","abstract":[{"lang":"eng","text":"The superficial layers of the superior colliculus (SC) have been known to contain many axons showing substance P-like immunoreactivity (SP-LI). We, therefore, immunohistochemically examined the distribution of SP receptor (SPR) in the superficial layers of the SC in the rat by using a specific antibody against SPR. The majority of SC neurons with SPR-LI were distributed in the zonal and the superficial gray layers, the rest of them were in the optic layer. Electron microscopy revealed that SPR-immunoreaction products in SC neurons were distributed not only in postsynaptic sites, but also in non-synaptic regions of perikaryal and dendritic profiles."}],"author":[{"full_name":"Ogawa Meguro, Reiko","last_name":"Ogawa Meguro","first_name":"Reiko"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"},{"full_name":"Itoh, Kazuo","last_name":"Itoh","first_name":"Kazuo"},{"last_name":"Konishi","first_name":"Akira","full_name":"Konishi, Akira"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"publication":"Neuroscience Letters","type":"journal_article","_id":"2552","issue":"2","article_processing_charge":"No","date_created":"2018-12-11T11:58:21Z","oa_version":"None","status":"public","title":"Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat","volume":166,"day":"31","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394094904693?via%3Dihub"}],"date_updated":"2022-06-08T14:37:30Z","publist_id":"4347","publisher":"Elsevier","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_type":"original","date_published":"1994-01-31T00:00:00Z","month":"01"},{"oa_version":"None","date_created":"2018-12-11T11:58:21Z","publication":"American Journal of Physiology","_id":"2553","type":"journal_article","issue":"5","article_processing_charge":"No","author":[{"last_name":"Sugimoto","first_name":"Yukihiko","full_name":"Sugimoto, Yukihiko"},{"last_name":"Namba","first_name":"Tsunehisa","full_name":"Namba, Tsunehisa"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Negishi, Manabu","last_name":"Negishi","first_name":"Manabu"},{"last_name":"Ichikawa","first_name":"Atsushi","full_name":"Ichikawa, Atsushi"},{"full_name":"Narumiya, Shuh","first_name":"Shuh","last_name":"Narumiya"}],"day":"01","title":"Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney","volume":266,"status":"public","main_file_link":[{"url":"https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823"}],"scopus_import":"1","article_type":"original","month":"05","date_published":"1994-05-01T00:00:00Z","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4345","date_updated":"2022-06-07T15:03:51Z","publisher":"American Physiological Society","quality_controlled":"1","citation":{"ama":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. 1994;266(5):F823-F828. doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>","mla":"Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>, vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>.","ista":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. American Journal of Physiology. 266(5), F823–F828.","ieee":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya, “Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney,” <i>American Journal of Physiology</i>, vol. 266, no. 5. American Physiological Society, pp. F823–F828, 1994.","short":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya, American Journal of Physiology 266 (1994) F823–F828.","chicago":"Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi, Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>. American Physiological Society, 1994. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>.","apa":"Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., &#38; Narumiya, S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. American Physiological Society. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>"},"doi":"10.1152/ajprenal.1994.266.5.F823","extern":"1","acknowledgement":"We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This work was supported in part by Scientific Research Grants-inAid 05404020, 04255103, 05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.","year":"1994","publication_identifier":{"issn":["0363-6127"]},"language":[{"iso":"eng"}],"intvolume":"       266","pmid":1,"page":"F823 - F828","external_id":{"pmid":["8203567"]},"abstract":[{"text":"Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1 subtype, which is coupled to Ca2+ mobilization, was specifically localized to the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype, which is linked to stimulation of adenylate cyclase, was localized to the glomeruli. The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase, was located densely in the tubules in the outer medulla and in the distal tubules in the cortex. These results exhibit distinct cellular localization of three subtypes of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions via these subtypes expressed in different segments of the nephron.","lang":"eng"}]},{"article_type":"original","date_published":"1994-05-06T00:00:00Z","month":"05","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-07T14:28:33Z","publist_id":"4344","publisher":"Cell Press","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0092867494901511?via%3Dihub"}],"scopus_import":"1","day":"06","title":"Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells","volume":77,"status":"public","oa_version":"None","date_created":"2018-12-11T11:58:21Z","publication":"Cell","_id":"2554","article_processing_charge":"No","type":"journal_article","issue":"3","author":[{"full_name":"Nomura, Akinori","first_name":"Akinori","last_name":"Nomura"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"first_name":"Yasuhisa","last_name":"Nakamura","full_name":"Nakamura, Yasuhisa"},{"full_name":"Okamoto, Naoyuki","last_name":"Okamoto","first_name":"Naoyuki"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"}],"abstract":[{"lang":"eng","text":"The retinal bipolar cell receiving glutamate transmission from photoreceptors mediates a key process in segregating visual signals into ON center and OFF center pathways. This transmission involves a G protein- coupled metabotropic glutamate receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic site of the rat rod bipolar cell. This specialization is developmentally regulated: mGluR6 is initially distributed in both the soma and dendrites and is finally concentrated on the postsynaptic site. The mGluR6 localization is reversed when photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is thus presented indicating specialized, developmentally regulated receptor distribution in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar cell synaptic transmission."}],"page":"361 - 369","external_id":{"pmid":["8181056"]},"year":"1994","publication_identifier":{"issn":["0092-8674"]},"language":[{"iso":"eng"}],"intvolume":"        77","pmid":1,"quality_controlled":"1","citation":{"mla":"Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>, vol. 77, no. 3, Cell Press, 1994, pp. 361–69, doi:<a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">10.1016/0092-8674(94)90151-1</a>.","ista":"Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 77(3), 361–369.","ieee":"A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi, “Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells,” <i>Cell</i>, vol. 77, no. 3. Cell Press, pp. 361–369, 1994.","chicago":"Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto, Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>. Cell Press, 1994. <a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">https://doi.org/10.1016/0092-8674(94)90151-1</a>.","short":"A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi, Cell 77 (1994) 361–369.","apa":"Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., &#38; Nakanishi, S. (1994). Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">https://doi.org/10.1016/0092-8674(94)90151-1</a>","ama":"Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. 1994;77(3):361-369. doi:<a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">10.1016/0092-8674(94)90151-1</a>"},"doi":"10.1016/0092-8674(94)90151-1","extern":"1","acknowledgement":"We thank M. Tachibana for technical advice concerning dissociated bipolar cell preparation, Y. Honda for advice \r\nconcerning RCS rat experiments, and A. Uesugi for photographic assistance. This work is partly supported by research grants from the Ministry of Education, Science, and Culture of Japan and from the Ministry of Health and Welfare of\r\nJapan. "},{"page":"1245 - 1255","external_id":{"pmid":["7912091 "]},"abstract":[{"lang":"eng","text":"Antibodies were raised against two distinct extracellular sequences of the rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins. Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we examined the role of mGluR1 in the induction of long-term depression in cultured Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically applied glutamate was persistently depressed by depolarization of the Purkinje cells in conjunction with the glutamate application. The mGluR1 antibodies completely blocked the depression of glutamate-induced current. The results indicate that activation of mGluR1 is necessary for the induction of cerebellar long-term depression and that these mGluR1 antibodies can be used as selective antagonists."}],"acknowledgement":"Correspondence should be addressed to R. S. The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from Senri Life Science Foundation, the Brain Science Foundation, the Narishige Foundation, and the Ministry of Education, Science, and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","doi":"10.1016/0896-6273(94)90441-3","citation":{"apa":"Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S., &#38; Hirano, T. (1994). Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">https://doi.org/10.1016/0896-6273(94)90441-3</a>","short":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, T. Hirano, Neuron 12 (1994) 1245–1255.","chicago":"Shigemoto, Ryuichi, Takaaki Abe, Sakashi Nomura, Shigetada Nakanishi, and Tomoo Hirano. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” <i>Neuron</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">https://doi.org/10.1016/0896-6273(94)90441-3</a>.","ista":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. 1994. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. 12(6), 1245–1255.","ieee":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, and T. Hirano, “Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells,” <i>Neuron</i>, vol. 12, no. 6. Elsevier, pp. 1245–1255, 1994.","mla":"Shigemoto, Ryuichi, et al. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” <i>Neuron</i>, vol. 12, no. 6, Elsevier, 1994, pp. 1245–55, doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">10.1016/0896-6273(94)90441-3</a>.","ama":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. <i>Neuron</i>. 1994;12(6):1245-1255. doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">10.1016/0896-6273(94)90441-3</a>"},"quality_controlled":"1","extern":"1","pmid":1,"intvolume":"        12","year":"1994","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904413?via%3Dihub"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Elsevier","date_updated":"2022-06-07T13:39:09Z","publist_id":"4343","date_published":"1994-06-01T00:00:00Z","month":"06","article_type":"original","author":[{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Abe","first_name":"Takaaki","full_name":"Abe, Takaaki"},{"full_name":"Nomura, Sakashi","last_name":"Nomura","first_name":"Sakashi"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"full_name":"Hirano, Tomoo","first_name":"Tomoo","last_name":"Hirano"}],"date_created":"2018-12-11T11:58:22Z","oa_version":"None","issue":"6","_id":"2555","type":"journal_article","article_processing_charge":"No","publication":"Neuron","volume":12,"title":"Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells","status":"public","day":"01"},{"title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex","volume":13,"status":"public","day":"01","author":[{"full_name":"Ohishi, Hitoshi","last_name":"Ohishi","first_name":"Hitoshi"},{"full_name":"Ogawa Meguro, Reiko","last_name":"Ogawa Meguro","first_name":"Reiko"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Takeshi","last_name":"Kaneko","full_name":"Kaneko, Takeshi"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"date_created":"2018-12-11T11:58:22Z","oa_version":"None","article_processing_charge":"No","_id":"2557","type":"journal_article","issue":"1","publication":"Neuron","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Elsevier","publist_id":"4342","date_updated":"2022-06-07T13:21:58Z","month":"07","date_published":"1994-07-01T00:00:00Z","article_type":"original","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904596?via%3Dihub"}],"pmid":1,"intvolume":"        13","year":"1994","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic help. This work has been supported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part\r\nby the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","doi":"10.1016/0896-6273(94)90459-6","citation":{"chicago":"Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” <i>Neuron</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">https://doi.org/10.1016/0896-6273(94)90459-6</a>.","short":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, N. Mizuno, Neuron 13 (1994) 55–66.","apa":"Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., &#38; Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">https://doi.org/10.1016/0896-6273(94)90459-6</a>","mla":"Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” <i>Neuron</i>, vol. 13, no. 1, Elsevier, 1994, pp. 55–66, doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">10.1016/0896-6273(94)90459-6</a>.","ieee":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex,” <i>Neuron</i>, vol. 13, no. 1. Elsevier, pp. 55–66, 1994.","ista":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.","ama":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. <i>Neuron</i>. 1994;13(1):55-66. doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">10.1016/0896-6273(94)90459-6</a>"},"quality_controlled":"1","extern":"1","abstract":[{"text":"The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3 was immunohistochemically examined in the rat cerebellar cortex at both light and electron microscope levels. An antibody was raised against a fusion protein containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. The results suggest that transmitter glutamate may exert control influences upon Golgi cells not only through dendritic mGluR2/3, but also through axonal mGluR2/3.","lang":"eng"}],"page":"55 - 66","external_id":{"pmid":["8043281"]}},{"page":"541 - 566","extern":"1","citation":{"ista":"Erdös L. 1994. Estimates on stochastic oscillatory integrals and on the heat kernel of the magnetic Schrödinger operator. Duke Mathematical Journal. 76(2), 541–566.","ieee":"L. Erdös, “Estimates on stochastic oscillatory integrals and on the heat kernel of the magnetic Schrödinger operator,” <i>Duke Mathematical Journal</i>, vol. 76, no. 2. Duke University Press, pp. 541–566, 1994.","mla":"Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the Heat Kernel of the Magnetic Schrödinger Operator.” <i>Duke Mathematical Journal</i>, vol. 76, no. 2, Duke University Press, 1994, pp. 541–66, doi:<a href=\"https://doi.org/10.1215/S0012-7094-94-07619-9\">10.1215/S0012-7094-94-07619-9</a>.","apa":"Erdös, L. (1994). Estimates on stochastic oscillatory integrals and on the heat kernel of the magnetic Schrödinger operator. <i>Duke Mathematical Journal</i>. Duke University Press. <a href=\"https://doi.org/10.1215/S0012-7094-94-07619-9\">https://doi.org/10.1215/S0012-7094-94-07619-9</a>","short":"L. Erdös, Duke Mathematical Journal 76 (1994) 541–566.","chicago":"Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the Heat Kernel of the Magnetic Schrödinger Operator.” <i>Duke Mathematical Journal</i>. Duke University Press, 1994. <a href=\"https://doi.org/10.1215/S0012-7094-94-07619-9\">https://doi.org/10.1215/S0012-7094-94-07619-9</a>.","ama":"Erdös L. Estimates on stochastic oscillatory integrals and on the heat kernel of the magnetic Schrödinger operator. <i>Duke Mathematical Journal</i>. 1994;76(2):541-566. doi:<a href=\"https://doi.org/10.1215/S0012-7094-94-07619-9\">10.1215/S0012-7094-94-07619-9</a>"},"doi":"10.1215/S0012-7094-94-07619-9","quality_controlled":"1","acknowledgement":"Work supported by the NSF grant PHY90-19433 A02 and by the Alfred Sloan Foundation dissertation fellowship.","publication_identifier":{"issn":["0012-7094"]},"language":[{"iso":"eng"}],"year":"1994","intvolume":"        76","main_file_link":[{"url":"https://projecteuclid.org/journals/duke-mathematical-journal/volume-76/issue-2/Estimates-on-stochastic-oscillatory-integrals-and-on-the-heat-kernel/10.1215/S0012-7094-94-07619-9.short"}],"scopus_import":"1","date_published":"1994-11-01T00:00:00Z","month":"11","article_type":"original","publisher":"Duke University Press","publist_id":"4183","date_updated":"2022-06-03T11:59:06Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","type":"journal_article","_id":"2713","issue":"2","article_processing_charge":"No","publication":"Duke Mathematical Journal","date_created":"2018-12-11T11:59:13Z","oa_version":"None","author":[{"full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös"}],"day":"01","status":"public","title":"Estimates on stochastic oscillatory integrals and on the heat kernel of the magnetic Schrödinger operator","volume":76},{"abstract":[{"lang":"eng","text":"Two edges e/sub 1/ and e/sub 2/ of an undirected graph are cycle-equivalent iff all cycles that contain e/sub 1/ also contain e/sub 2/, i.e., iff e/sub 1/ and e/sub 2/ are a cut-edge pair. The cycle-equivalence classes of the control-flow graph are used in optimizing compilers to speed up existing control-flow and data-flow algorithms. While the cycle-equivalence classes can be computed in linear time, we present the first fully dynamic algorithm for maintaining the cycle-equivalence relation. In an n-node graph our data structure executes an edge insertion or deletion in O(/spl radic/n log n) time and answers the query whether two given edges are cycle-equivalent in O(log/sup 2/ n) time. We also present an algorithm for plane graphs with O(log n) update and query time and for planar graphs with O(log n) insertion time and O(log/sup 2/ n) query and deletion time. Additionally, we show a lower bound of /spl Omega/(log n/log log n) for the amortized time per operation for the dynamic cycle-equivalence problem in the cell probe model.< >"}],"date_published":"1994-11-01T00:00:00Z","month":"11","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","publisher":"Institute of Electrical and Electronics Engineers","date_updated":"2023-02-17T09:58:04Z","page":"744 - 755","scopus_import":"1","day":"01","year":"1994","publication_identifier":{"isbn":["0-8186-6580-7"]},"language":[{"iso":"eng"}],"title":"Fully dynamic cycle-equivalence in graphs","status":"public","doi":"10.1109/sfcs.1994.365718","citation":{"apa":"Henzinger, M. H. (1994). Fully dynamic cycle-equivalence in graphs. In <i>35th Annual Symposium on Foundations of Computer Science</i> (pp. 744–755). Santa Fe, NM, United States: Institute of Electrical and Electronics Engineers. <a href=\"https://doi.org/10.1109/sfcs.1994.365718\">https://doi.org/10.1109/sfcs.1994.365718</a>","short":"M.H. Henzinger, in:, 35th Annual Symposium on Foundations of Computer Science, Institute of Electrical and Electronics Engineers, 1994, pp. 744–755.","chicago":"Henzinger, Monika H. “Fully Dynamic Cycle-Equivalence in Graphs.” In <i>35th Annual Symposium on Foundations of Computer Science</i>, 744–55. Institute of Electrical and Electronics Engineers, 1994. <a href=\"https://doi.org/10.1109/sfcs.1994.365718\">https://doi.org/10.1109/sfcs.1994.365718</a>.","ista":"Henzinger MH. 1994. Fully dynamic cycle-equivalence in graphs. 35th Annual Symposium on Foundations of Computer Science. FOCS: Symposium on Foundations of Computer Science, 744–755.","ieee":"M. H. Henzinger, “Fully dynamic cycle-equivalence in graphs,” in <i>35th Annual Symposium on Foundations of Computer Science</i>, Santa Fe, NM, United States, 1994, pp. 744–755.","mla":"Henzinger, Monika H. “Fully Dynamic Cycle-Equivalence in Graphs.” <i>35th Annual Symposium on Foundations of Computer Science</i>, Institute of Electrical and Electronics Engineers, 1994, pp. 744–55, doi:<a href=\"https://doi.org/10.1109/sfcs.1994.365718\">10.1109/sfcs.1994.365718</a>.","ama":"Henzinger MH. Fully dynamic cycle-equivalence in graphs. In: <i>35th Annual Symposium on Foundations of Computer Science</i>. Institute of Electrical and Electronics Engineers; 1994:744-755. doi:<a href=\"https://doi.org/10.1109/sfcs.1994.365718\">10.1109/sfcs.1994.365718</a>"},"oa_version":"None","date_created":"2022-08-16T08:29:08Z","quality_controlled":"1","_id":"11857","type":"conference","article_processing_charge":"No","extern":"1","publication":"35th Annual Symposium on Foundations of Computer Science","author":[{"last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530"}],"conference":{"location":"Santa Fe, NM, United States","end_date":"1994-11-22","start_date":"1994-11-20","name":"FOCS: Symposium on Foundations of Computer Science"}},{"oa_version":"None","date_created":"2018-12-11T11:54:52Z","_id":"1947","issue":"2","article_processing_charge":"No","type":"journal_article","publication":"Biochimica et Biophysica Acta - Bioenergetics","author":[{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","last_name":"Sazanov","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Julie","last_name":"Jackson","full_name":"Jackson, Julie"}],"day":"13","volume":1144,"title":"Activation and inhibition of mitochondrial transhydrogenase by metal ions","status":"public","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/000527289390177H?via%3Dihub"}],"scopus_import":"1","date_published":"1993-09-13T00:00:00Z","month":"09","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Elsevier","date_updated":"2022-06-01T12:51:32Z","publist_id":"5136","citation":{"ista":"Sazanov LA, Jackson J. 1993. Activation and inhibition of mitochondrial transhydrogenase by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1144(2), 225–228.","ieee":"L. A. Sazanov and J. Jackson, “Activation and inhibition of mitochondrial transhydrogenase by metal ions,” <i>Biochimica et Biophysica Acta - Bioenergetics</i>, vol. 1144, no. 2. Elsevier, pp. 225–228, 1993.","mla":"Sazanov, Leonid A., and Julie Jackson. “Activation and Inhibition of Mitochondrial Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>, vol. 1144, no. 2, Elsevier, 1993, pp. 225–28, doi:<a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">10.1016/0005-2728(93)90177-H</a>.","apa":"Sazanov, L. A., &#38; Jackson, J. (1993). Activation and inhibition of mitochondrial transhydrogenase by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">https://doi.org/10.1016/0005-2728(93)90177-H</a>","short":"L.A. Sazanov, J. Jackson, Biochimica et Biophysica Acta - Bioenergetics 1144 (1993) 225–228.","chicago":"Sazanov, Leonid A, and Julie Jackson. “Activation and Inhibition of Mitochondrial Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>. Elsevier, 1993. <a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">https://doi.org/10.1016/0005-2728(93)90177-H</a>.","ama":"Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>. 1993;1144(2):225-228. doi:<a href=\"https://doi.org/10.1016/0005-2728(93)90177-H\">10.1016/0005-2728(93)90177-H</a>"},"doi":"10.1016/0005-2728(93)90177-H","quality_controlled":"1","extern":"1","acknowledgement":"This work was supported by a Wellcome Trust fellowship to L.A.S. ","year":"1993","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0005-2728"]},"pmid":1,"intvolume":"      1144","page":"225 - 228","external_id":{"pmid":["8369341 "]},"abstract":[{"lang":"eng","text":"Mitochondrial transhydrogenase has been reported previously to be inhibited by high, rather non-physiological concentrations (in the range of 2-20 mM) of divalent cations. We show that the enzyme could be activated by low (from about 1 μM to 1 mM) concentrations of Ca2+ and Mg2+, which are within physiological range. These results bring in line the effects observed with mitochondrial enzyme to the findings with bacterial transhydrogenases. The activation of transhydrogenase by divalent cations is interpreted as an increase in affinity of the NADP(H)-binding site of the enzyme-NAD(H) complex. Reported effects of the metal ions could be important for the enzyme function in vivo."}]},{"page":"260","external_id":{"pmid":["8224412 "]},"pmid":1,"intvolume":"        21","year":"1993","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0300-5127"]},"acknowledgement":"We acknowledge financial support from the Wellcome Trust (fellowship to L.A.S) ","citation":{"ama":"Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . <i>Biochemical Society Transactions</i>. 1993;21(3):260. doi:<a href=\"https://doi.org/10.1042/bst021260s\">10.1042/bst021260s</a>","apa":"Sazanov, L. A., &#38; Jackson, J. (1993). Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst021260s\">https://doi.org/10.1042/bst021260s</a>","short":"L.A. Sazanov, J. Jackson, Biochemical Society Transactions 21 (1993) 260.","chicago":"Sazanov, Leonid A, and Julie Jackson. “Possible Functions of the NADP-Linked Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical Society Transactions</i>. Portland Press, 1993. <a href=\"https://doi.org/10.1042/bst021260s\">https://doi.org/10.1042/bst021260s</a>.","ieee":"L. A. Sazanov and J. Jackson, “Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria ,” <i>Biochemical Society Transactions</i>, vol. 21, no. 3. Portland Press, p. 260, 1993.","ista":"Sazanov LA, Jackson J. 1993. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society Transactions. 21(3), 260.","mla":"Sazanov, Leonid A., and Julie Jackson. “Possible Functions of the NADP-Linked Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical Society Transactions</i>, vol. 21, no. 3, Portland Press, 1993, p. 260, doi:<a href=\"https://doi.org/10.1042/bst021260s\">10.1042/bst021260s</a>."},"doi":"10.1042/bst021260s","quality_controlled":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Portland Press","publist_id":"5137","date_updated":"2022-06-01T13:17:02Z","date_published":"1993-01-01T00:00:00Z","month":"01","article_type":"original","scopus_import":"1","main_file_link":[{"url":"https://portlandpress.com/biochemsoctrans/article-abstract/21/3/260S/83260/Possible-functions-of-the-NADP-linked-isocitrate?redirectedFrom=fulltext"}],"title":"Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria ","volume":21,"status":"public","day":"01","author":[{"orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov"},{"full_name":"Jackson, Julie","last_name":"Jackson","first_name":"Julie"}],"oa_version":"None","date_created":"2018-12-11T11:54:52Z","_id":"1948","type":"journal_article","article_processing_charge":"No","issue":"3","publication":"Biochemical Society Transactions"},{"intvolume":"        21","pmid":1,"year":"1993","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0300-5127"]},"quality_controlled":"1","doi":"10.1042/bst0211010","citation":{"ama":"Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase in bacteria. <i>Biochemical Society Transactions</i>. 1993;21(4):1010-1013. doi:<a href=\"https://doi.org/10.1042/bst0211010\">10.1042/bst0211010</a>","ieee":"J. Jackson <i>et al.</i>, “Proton-translocating transhydrogenase in bacteria,” <i>Biochemical Society Transactions</i>, vol. 21, no. 4. Portland Press, pp. 1010–1013, 1993.","ista":"Jackson J, Cotton NPJ, Williams R, Bizouarn T, Hutton M, Sazanov LA, Thomas C. 1993. Proton-translocating transhydrogenase in bacteria. Biochemical Society Transactions. 21(4), 1010–1013.","mla":"Jackson, Julie, et al. “Proton-Translocating Transhydrogenase in Bacteria.” <i>Biochemical Society Transactions</i>, vol. 21, no. 4, Portland Press, 1993, pp. 1010–13, doi:<a href=\"https://doi.org/10.1042/bst0211010\">10.1042/bst0211010</a>.","apa":"Jackson, J., Cotton, N. P. J., Williams, R., Bizouarn, T., Hutton, M., Sazanov, L. A., &#38; Thomas, C. (1993). Proton-translocating transhydrogenase in bacteria. <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst0211010\">https://doi.org/10.1042/bst0211010</a>","short":"J. Jackson, N.P.J. Cotton, R. Williams, T. Bizouarn, M. Hutton, L.A. Sazanov, C. Thomas, Biochemical Society Transactions 21 (1993) 1010–1013.","chicago":"Jackson, Julie, N P J Cotton, Ross Williams, Tania Bizouarn, Mike Hutton, Leonid A Sazanov, and Christopher Thomas. “Proton-Translocating Transhydrogenase in Bacteria.” <i>Biochemical Society Transactions</i>. Portland Press, 1993. <a href=\"https://doi.org/10.1042/bst0211010\">https://doi.org/10.1042/bst0211010</a>."},"extern":"1","page":"1010 - 1013","external_id":{"pmid":["8131888"]},"volume":21,"title":"Proton-translocating transhydrogenase in bacteria","status":"public","day":"01","author":[{"full_name":"Jackson, Julie","last_name":"Jackson","first_name":"Julie"},{"full_name":"Cotton, N P J","first_name":"N P J","last_name":"Cotton"},{"last_name":"Williams","first_name":"Ross","full_name":"Williams, Ross"},{"full_name":"Bizouarn, Tania","last_name":"Bizouarn","first_name":"Tania"},{"full_name":"Hutton, Mike","last_name":"Hutton","first_name":"Mike"},{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A"},{"full_name":"Thomas, Christopher","first_name":"Christopher","last_name":"Thomas"}],"date_created":"2018-12-11T11:54:52Z","oa_version":"None","publication":"Biochemical Society Transactions","_id":"1950","article_processing_charge":"No","type":"journal_article","issue":"4","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"5135","date_updated":"2022-06-01T12:16:19Z","publisher":"Portland Press","article_type":"original","date_published":"1993-11-01T00:00:00Z","month":"11","scopus_import":"1","main_file_link":[{"url":"https://portlandpress.com/biochemsoctrans/article-abstract/21/4/1010/86733/Proton-translocating-transhydrogenase-in-bacteria?redirectedFrom=fulltext"}]},{"publication_identifier":{"issn":["1057-7130"]},"language":[{"iso":"eng"}],"year":"1993","intvolume":"        40","extern":"1","quality_controlled":"1","doi":"10.1109/82.222823","citation":{"short":"T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing 40 (1993) 223–231.","chicago":"Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE, 1993. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>.","apa":"Sziranyi, T., &#38; Csicsvari, J. L. (1993). High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE. <a href=\"https://doi.org/10.1109/82.222823\">https://doi.org/10.1109/82.222823</a>","mla":"Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3, IEEE, 1993, pp. 223–31, doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>.","ieee":"T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using a dual cellular neural network architecture (CNND),” <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3. IEEE, pp. 223–231, 1993.","ista":"Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a dual cellular neural network architecture (CNND). IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.","ama":"Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing</i>. 1993;40(3):223-231. doi:<a href=\"https://doi.org/10.1109/82.222823\">10.1109/82.222823</a>"},"abstract":[{"lang":"eng","text":"An effective character recognition procedure implemented on a new type of hardware system and using a new architecture called CNND is proposed. This CNND contains one or more analog cellular neural networks (CNNs) and some digital logic, combining the advantages of the fast analog CNN signal processing and the fast and easy decision capability of digital logic. It is shown that the CNND system can be used for recognition of multifont printed or handwritten characters and could recognize 100,000 char/s with a recognition rate of more than 95%. The more advantage of the system over competing types is that there is not an extra feature extraction procedure implemented in slow hardware"}],"page":"223 - 231","day":"01","status":"public","volume":40,"title":"High-speed character recognition using a dual cellular neural network architecture (CNND)","publication":"IEEE Transactions on Circuits and Systems II: Analog and Digital Signal Processing","_id":"3446","type":"journal_article","article_processing_charge":"No","issue":"3","oa_version":"None","date_created":"2018-12-11T12:03:22Z","author":[{"full_name":"Sziranyi, Tamas","first_name":"Tamas","last_name":"Sziranyi"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"article_type":"original","date_published":"1993-03-01T00:00:00Z","month":"03","date_updated":"2022-03-30T14:44:44Z","publist_id":"2941","publisher":"IEEE","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/222823"}],"scopus_import":"1"},{"quality_controlled":"1","doi":"10.1111/j.1749-6632.1993.tb38048.x","citation":{"ama":"Jonas PM. Glutamate receptors in the central nervous system. In: <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>. Vol 707. Annals of the New York Academy of Sciences. New York Academy of Sciences; 1993:126-135. doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>","ista":"Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707, 126–135.","ieee":"P. M. Jonas, “Glutamate receptors in the central nervous system,” in <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–135.","mla":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp. 126–35, doi:<a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">10.1111/j.1749-6632.1993.tb38048.x</a>.","apa":"Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i> (Vol. 707, pp. 126–135). New York Academy of Sciences. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>","chicago":"Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction</i>, 707:126–35. Annals of the New York Academy of Sciences. New York Academy of Sciences, 1993. <a href=\"https://doi.org/10.1111/j.1749-6632.1993.tb38048.x\">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>.","short":"P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy of Sciences, 1993, pp. 126–135."},"extern":"1","acknowledgement":"I thank Prof. B. Sakmann for generous support and Drs. M. Häusser and A. Villarroel for critically reading the manuscript.","year":"1993","language":[{"iso":"eng"}],"intvolume":"       707","pmid":1,"alternative_title":["Annals of the New York Academy of Sciences "],"page":"126 - 135","external_id":{"pmid":["9729204"]},"date_created":"2018-12-11T12:03:24Z","oa_version":"None","publication":"Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission, and Muscle Contraction","type":"book_chapter","_id":"3451","article_processing_charge":"No","author":[{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"day":"20","volume":707,"title":"Glutamate receptors in the central nervous system","status":"public","main_file_link":[{"url":"https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x"}],"scopus_import":"1","series_title":"Annals of the New York Academy of Sciences","date_published":"1993-12-20T00:00:00Z","month":"12","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-03-30T12:35:23Z","publist_id":"2936","publisher":"New York Academy of Sciences"},{"status":"public","title":"AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS","volume":66,"day":"01","author":[{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"type":"book_chapter","_id":"3452","article_processing_charge":"No","publication":"Nonselective cation channels: Pharmacology, Physiology and Biophysics.","oa_version":"None","date_created":"2018-12-11T12:03:24Z","publisher":"Birkhäuser","date_updated":"2022-03-30T11:46:44Z","publist_id":"2935","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","date_published":"1993-01-01T00:00:00Z","month":"01","scopus_import":"1","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4"}],"pmid":1,"intvolume":"        66","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["978-3-0348-7327-7"]},"year":"1993","extern":"1","citation":{"ista":"Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Nonselective cation channels: Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.","ieee":"P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS,” in <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i>, vol. 66, D. Siemen, Ed. Birkhäuser, 1993, pp. 61–76.","mla":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, vol. 66, Birkhäuser, 1993, pp. 61–76, doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>.","apa":"Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), <i>Nonselective cation channels: Pharmacology, Physiology and Biophysics.</i> (Vol. 66, pp. 61–76). Birkhäuser. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>","chicago":"Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels Mediating Fast Excitatory Transmission in the CNS.” In <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, 66:61–76. Birkhäuser, 1993. <a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">https://doi.org/10.1007/978-3-0348-7327-7_4</a>.","short":"P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology, Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.","ama":"Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating fast excitatory transmission in the CNS. In: Siemen D, ed. <i>Nonselective Cation Channels: Pharmacology, Physiology and Biophysics.</i> Vol 66. Birkhäuser; 1993:61-76. doi:<a href=\"https://doi.org/10.1007/978-3-0348-7327-7_4\">10.1007/978-3-0348-7327-7_4</a>"},"doi":"10.1007/978-3-0348-7327-7_4","quality_controlled":"1","abstract":[{"lang":"eng","text":"In recent years, considerable progress in our understanding of the molecular events underlying excitatory synaptic transmission has been made. This progress was mainly achieved by technical advances, among them the patch-clamp technique in brain slices (Edwards et al., 1989), fast application of agonists (Franke et al., 1987), and cloning and functional expression of GluR channels of the nonNMDA type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse is located close to the cell soma and should provide almost ideal space-clamp conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application of glutamate on membrane patches isolated from CA3 cell somata suggests that the concentration of glutamate in the synaptic cleft during excitatory synaptic transmission is high (about 1 mM) and that the transmitter remains in the synaptic cleft only briefly (about 1 ms). It seems likely that desensitization influences the peak amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization, from which the glutamate receptor channels recover only slowly, and micromolar ambient glutamate concentrations produce desensitization at equilibrium. From the functional properties of recombinant GluR channels, in situ hybridization data, and patch-clamp experiments on different neuronal and nonneuronal cell types, a picture of the molecular identity of native channels emerges. In neurons of the hippocampus the pharmacological features of these channels were similar to recombinant channels assembled from subunits of the AMPA/kainate subtype which are strongly expressed in these cells. The native channels are characterized by outward rectification of the steady-state I-V and low Ca permeability, similar to recombinant channels containing the GluR-B subunit. This is consistent with the ubiquitous expression of this subunit in hippocampal neurones. In contrast, GluR channels from cerebellar glial cells, which uniquely in the central nervous system lack the expression of GluR-B subunits, show double rectification and high Ca permeability. The results suggest that the native functional nonNMDA glutamate receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype in a cell-specific way, with the functional properties of GluR channels in neurones being dominated by the GluR-B subunit."}],"external_id":{"pmid":["7505664"]},"page":"61 - 76","alternative_title":["EXS"],"editor":[{"first_name":"Detlef","last_name":"Siemen","full_name":"Siemen, Detlef"}]},{"date_created":"2018-12-11T12:03:31Z","oa_version":"None","_id":"3473","type":"journal_article","article_processing_charge":"No","publication":"Cellular Physiology and Biochemistry","author":[{"full_name":"Ruppersberg, Peter","first_name":"Peter","last_name":"Ruppersberg"},{"last_name":"Ermler","first_name":"Mamfred","full_name":"Ermler, Mamfred"},{"first_name":"Martin","last_name":"Knopf","full_name":"Knopf, Martin"},{"full_name":"Kues, Wilfried","first_name":"Wilfried","last_name":"Kues"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"},{"last_name":"Koenen","first_name":"Michael","full_name":"Koenen, Michael"}],"day":"01","volume":3,"title":"Properties of Shaker-homologous potassium channels expressed in the mammalian brain.","status":"public","main_file_link":[{"url":"https://www.karger.com/Article/Abstract/154691"}],"scopus_import":"1","date_published":"1993-01-01T00:00:00Z","month":"01","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"S. Karger AG","publist_id":"2914","date_updated":"2022-03-30T10:21:04Z","doi":"10.1159/000154691","citation":{"mla":"Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>, vol. 3, S. Karger AG, 1993, pp. 250–69, doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>.","ieee":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen, “Properties of Shaker-homologous potassium channels expressed in the mammalian brain.,” <i>Cellular Physiology and Biochemistry</i>, vol. 3. S. Karger AG, pp. 250–269, 1993.","ista":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular Physiology and Biochemistry. 3, 250–269.","chicago":"Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>. S. Karger AG, 1993. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>.","short":"P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular Physiology and Biochemistry 3 (1993) 250–269.","apa":"Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., &#38; Koenen, M. (1993). Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. S. Karger AG. <a href=\"https://doi.org/10.1159/000154691\">https://doi.org/10.1159/000154691</a>","ama":"Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular Physiology and Biochemistry</i>. 1993;3:250-269. doi:<a href=\"https://doi.org/10.1159/000154691\">10.1159/000154691</a>"},"quality_controlled":"1","extern":"1","year":"1993","language":[{"iso":"eng"}],"publication_identifier":{"issn":["1015-8987"]},"intvolume":"         3","page":"250 - 269","abstract":[{"text":"Sixteen different K+ channel subtypes have been cloned from mammalian tissue. Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal channels, they were classified into four corresponding classes Kv1-4. All K+ channels belonging to these classes consist of four subunits with each six hydrophobic segments (S1-S6) and a characteristic structure-function relationship of certain domains in their amino acid sequence. These domains are, the inactivation gate in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic segment (S4), and the pore-region in the H5 segment between S5 and S6. In some functional properties K+ channels cloned from the mammalian brain, however, differ from Drosophila K+ channels. These are pharmacological differences, differences in the threshold of activation and in regulation of inactivation. Part of these differences are important to understand their physiological role in the brain. Based on their functional characteristics the expression pattern of cloned K+ channels in the rat brain can be correlated with the properties of K+ currents measured in central neurones.","lang":"eng"}]},{"extern":"1","quality_controlled":"1","doi":"10.1113/jphysiol.1993.sp019965","citation":{"short":"P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.","chicago":"Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>. Wiley-Blackwell, 1993. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>.","apa":"Jonas, P. M., Major, G., &#38; Sakmann, B. (1993). Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">https://doi.org/10.1113/jphysiol.1993.sp019965</a>","mla":"Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>, vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>.","ieee":"P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” <i>Journal of Physiology</i>, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.","ista":"Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology. 472, 615–663.","ama":"Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>. 1993;472:615-663. doi:<a href=\"https://doi.org/10.1113/jphysiol.1993.sp019965\">10.1113/jphysiol.1993.sp019965</a>"},"acknowledgement":"We are indebted to Professor B. Katz for critically reading the manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun for several discussions, for generously providing the source codes of programs for maximum-likelihood fit with sums of Gaussian functions, a routine for calculating the error function and for critically reading the manuscript. We also thank Drs A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser for excellent technical assistance. Part of the project was supported by the Deutsche Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust.","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0022-3751"]},"year":"1993","intvolume":"       472","pmid":1,"external_id":{"pmid":["7908327"]},"page":"615 - 663","abstract":[{"lang":"eng","text":"1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were evoked by extracellular stimulation of the mossy fibre tract. Using the selective blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor-mediated component and a minor NMDA receptor-mediated component with slower time course were distinguished. For the AMPA/kainate receptor-mediated component, the peak current-voltage (I-V) relation was linear, with a reversal potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353 nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude as a function of stimulus intensity showed all-or-none behaviour. The region of low threshold was restricted to a few micrometres. This suggests that extracellular stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0 ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest rise (rise time 0.5 ms or less) could be described by a single exponential function; the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells). 5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation fluctuated between trials. The apparent EPSC peak conductance in normal extracellular solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+ concentration and increasing the Mg2+ concentration reduced the mean peak amplitude in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and the presence of peaks and dips in the autocorrelation function, five of nine EPSC peak amplitude distributions were judged to be quantal."}],"oa":1,"publication":"Journal of Physiology","_id":"3474","type":"journal_article","article_processing_charge":"No","oa_version":"Published Version","date_created":"2018-12-11T12:03:31Z","author":[{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"},{"first_name":"Guy","last_name":"Major","full_name":"Major, Guy"},{"full_name":"Sakmann, Bert","first_name":"Bert","last_name":"Sakmann"}],"day":"01","status":"public","volume":472,"title":"Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505","open_access":"1"}],"scopus_import":"1","article_type":"original","date_published":"1993-12-01T00:00:00Z","month":"12","publist_id":"2913","date_updated":"2022-03-30T09:33:19Z","publisher":"Wiley-Blackwell","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"main_file_link":[{"url":"https://www.sciencedirect.com/book/9780444895967/handbook-of-convex-geometry"}],"page":"699 - 735","month":"08","date_published":"1993-08-24T00:00:00Z","date_updated":"2022-03-30T09:30:11Z","publist_id":"2817","publisher":"North Holland","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Handbook of Convex Geometry","extern":"1","article_processing_charge":"No","_id":"3568","type":"book_chapter","date_created":"2018-12-11T12:04:00Z","oa_version":"None","doi":"10.1016/C2009-0-15705-7","citation":{"ama":"Edelsbrunner H. Geometric algorithms. In: <i>Handbook of Convex Geometry</i>. North Holland; 1993:699-735. doi:<a href=\"https://doi.org/10.1016/C2009-0-15705-7\">10.1016/C2009-0-15705-7</a>","chicago":"Edelsbrunner, Herbert. “Geometric Algorithms.” In <i>Handbook of Convex Geometry</i>, 699–735. North Holland, 1993. <a href=\"https://doi.org/10.1016/C2009-0-15705-7\">https://doi.org/10.1016/C2009-0-15705-7</a>.","short":"H. Edelsbrunner, in:, Handbook of Convex Geometry, North Holland, 1993, pp. 699–735.","apa":"Edelsbrunner, H. (1993). Geometric algorithms. In <i>Handbook of Convex Geometry</i> (pp. 699–735). North Holland. <a href=\"https://doi.org/10.1016/C2009-0-15705-7\">https://doi.org/10.1016/C2009-0-15705-7</a>","mla":"Edelsbrunner, Herbert. “Geometric Algorithms.” <i>Handbook of Convex Geometry</i>, North Holland, 1993, pp. 699–735, doi:<a href=\"https://doi.org/10.1016/C2009-0-15705-7\">10.1016/C2009-0-15705-7</a>.","ieee":"H. Edelsbrunner, “Geometric algorithms,” in <i>Handbook of Convex Geometry</i>, North Holland, 1993, pp. 699–735.","ista":"Edelsbrunner H. 1993.Geometric algorithms. In: Handbook of Convex Geometry. , 699–735."},"author":[{"orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"}],"publication_identifier":{"isbn":["978-0-444-89596-7"]},"language":[{"iso":"eng"}],"year":"1993","day":"24","status":"public","title":"Geometric algorithms"}]