[{"conference":{"name":"CAV: Computer Aided Verification","end_date":"1995-07-05","location":"Liege, Belgium","start_date":"1995-07-03"},"scopus_import":"1","quality_controlled":"1","date_published":"1995-01-01T00:00:00Z","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","last_name":"Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A"},{"first_name":"Pei","last_name":"Ho","full_name":"Ho, Pei"}],"date_updated":"2022-06-10T09:48:52Z","doi":"10.1007/3-540-60045-0_53","alternative_title":["LNCS"],"article_processing_charge":"No","intvolume":"       939","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-60045-0_53"}],"publication_status":"published","language":[{"iso":"eng"}],"month":"01","day":"01","oa_version":"None","date_created":"2018-12-11T12:08:55Z","publist_id":"280","title":"Algorithmic analysis of nonlinear hybrid systems","publication":"7th International Conference on Computer Aided Verification","publisher":"Springer","abstract":[{"text":"Hybrid systems model discrete programs that are embedded in continuous environments. Model-checking tools are available for the analysis of linear hybrid systems, whose continuous variables are bounded by piecewise-linear trajectories. Most embedded programs, however, operate in nonlinear environments. We present, analyze, and apply two algorithms for translating nonlinear hybrid systems into linear hybrid systems.\r\nThe clock translation replaces nonlinear variables by clock variables; the rate translation approximates nonlinear variables by piecewise-linear envelopes. Both translations are sound for reachability; that is, if we establish a safety property of the translated linear system, we may conclude that the original nonlinear system satisfies the property. The clock translation is also complete for reachability; that is, the original system and the translated system satisfy the same safety properties. The two translations apply to incomparable classes of nonlinear hybrid systems. From the clock translation we obtain a new decidability result for hybrid systems.\r\nWith the help of Hytech, a symbolic model checker for linear hybrid systems, we automatically verify a nonlinear railroad gate control program using the clock translation, and a nonlinear temperature control program using the rate translation.","lang":"eng"}],"extern":"1","_id":"4450","year":"1995","page":"225 - 238","volume":939,"type":"conference","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ieee":"T. A. Henzinger and P. Ho, “Algorithmic analysis of nonlinear hybrid systems,” in <i>7th International Conference on Computer Aided Verification</i>, Liege, Belgium, 1995, vol. 939, pp. 225–238.","chicago":"Henzinger, Thomas A, and Pei Ho. “Algorithmic Analysis of Nonlinear Hybrid Systems.” In <i>7th International Conference on Computer Aided Verification</i>, 939:225–38. Springer, 1995. <a href=\"https://doi.org/10.1007/3-540-60045-0_53\">https://doi.org/10.1007/3-540-60045-0_53</a>.","apa":"Henzinger, T. A., &#38; Ho, P. (1995). Algorithmic analysis of nonlinear hybrid systems. In <i>7th International Conference on Computer Aided Verification</i> (Vol. 939, pp. 225–238). Liege, Belgium: Springer. <a href=\"https://doi.org/10.1007/3-540-60045-0_53\">https://doi.org/10.1007/3-540-60045-0_53</a>","ama":"Henzinger TA, Ho P. Algorithmic analysis of nonlinear hybrid systems. In: <i>7th International Conference on Computer Aided Verification</i>. Vol 939. Springer; 1995:225-238. doi:<a href=\"https://doi.org/10.1007/3-540-60045-0_53\">10.1007/3-540-60045-0_53</a>","ista":"Henzinger TA, Ho P. 1995. Algorithmic analysis of nonlinear hybrid systems. 7th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 939, 225–238.","short":"T.A. Henzinger, P. Ho, in:, 7th International Conference on Computer Aided Verification, Springer, 1995, pp. 225–238.","mla":"Henzinger, Thomas A., and Pei Ho. “Algorithmic Analysis of Nonlinear Hybrid Systems.” <i>7th International Conference on Computer Aided Verification</i>, vol. 939, Springer, 1995, pp. 225–38, doi:<a href=\"https://doi.org/10.1007/3-540-60045-0_53\">10.1007/3-540-60045-0_53</a>."},"publication_identifier":{"isbn":["9783540494133"]},"status":"public","acknowledgement":"This research was supported in part by the NSF grant CCR-9200794, by the AFOSR contract F49620-93-1-0056, and by the DARPA grant NAG2-892."},{"language":[{"iso":"eng"}],"month":"01","day":"01","publication_status":"published","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-60630-0_3"}],"intvolume":"      1019","quality_controlled":"1","scopus_import":"1","date_updated":"2022-06-10T09:00:05Z","alternative_title":["LNCS"],"doi":"10.1007/3-540-60630-0_3","article_processing_charge":"No","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A"},{"full_name":"Ho, Pei","first_name":"Pei","last_name":"Ho"},{"first_name":"Howard","last_name":"Wong Toi","full_name":"Wong Toi, Howard"}],"date_published":"1995-01-01T00:00:00Z","conference":{"name":"TACAS: Tools and Algorithms for the Construction and Analysis of Systems","end_date":"1995-05-20","location":"Aarhus, Denmark","start_date":"1995-05-19"},"publication_identifier":{"isbn":["9783540606307"]},"citation":{"ieee":"T. A. Henzinger, P. Ho, and H. Wong Toi, “A user guide to HyTech,” in <i>1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems</i>, Aarhus, Denmark, 1995, vol. 1019, pp. 41–71.","chicago":"Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “A User Guide to HyTech.” In <i>1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems</i>, 1019:41–71. Springer, 1995. <a href=\"https://doi.org/10.1007/3-540-60630-0_3\">https://doi.org/10.1007/3-540-60630-0_3</a>.","apa":"Henzinger, T. A., Ho, P., &#38; Wong Toi, H. (1995). A user guide to HyTech. In <i>1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems</i> (Vol. 1019, pp. 41–71). Aarhus, Denmark: Springer. <a href=\"https://doi.org/10.1007/3-540-60630-0_3\">https://doi.org/10.1007/3-540-60630-0_3</a>","ama":"Henzinger TA, Ho P, Wong Toi H. A user guide to HyTech. In: <i>1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems</i>. Vol 1019. Springer; 1995:41-71. doi:<a href=\"https://doi.org/10.1007/3-540-60630-0_3\">10.1007/3-540-60630-0_3</a>","ista":"Henzinger TA, Ho P, Wong Toi H. 1995. A user guide to HyTech. 1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems. TACAS: Tools and Algorithms for the Construction and Analysis of Systems, LNCS, vol. 1019, 41–71.","short":"T.A. Henzinger, P. Ho, H. Wong Toi, in:, 1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems, Springer, 1995, pp. 41–71.","mla":"Henzinger, Thomas A., et al. “A User Guide to HyTech.” <i>1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems</i>, vol. 1019, Springer, 1995, pp. 41–71, doi:<a href=\"https://doi.org/10.1007/3-540-60630-0_3\">10.1007/3-540-60630-0_3</a>."},"status":"public","acknowledgement":"This research was supported in part by the ONR YIP award N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by the NSF grants CCR-9200794 and CCR-9504469, by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.","year":"1995","_id":"4497","type":"conference","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"41 - 71","volume":1019,"extern":"1","abstract":[{"lang":"eng","text":"HyTech is a tool for the automated analysis of embedded systems. This document, designed for the first-time user of HyTech, guides the reader through the underlying system model, and through the input language for describing and analyzing systems. The guide gives several examples of usage, and some hints for gaining maximal computational efficiency from the tool.\r\nThe version of HyTech described in this guide was released in August 1995, and is available through anonymous ftp from ftp.cs.cornell.edu in the directory pub/tah/HyTech, and through the World-Wide Web via HyTech's home page http:/www.cs.cornell.edu/Info/People/tah/hytech.html."}],"publist_id":"230","oa_version":"None","date_created":"2018-12-11T12:09:09Z","publisher":"Springer","title":"A user guide to HyTech","publication":"1st International Workshop on Tools and Algorithms for the Construction and Analysis of Systems"},{"scopus_import":"1","abstract":[{"lang":"eng","text":"We present algorithms for computing similarity relations of labeled graphs. Similarity relations have applications for the refinement and verification of reactive systems. For finite graphs, we present an O(mn) algorithm for computing the similarity relation of a graph with n vertices and m edges (assuming m⩾n). For effectively presented infinite graphs, we present a symbolic similarity-checking procedure that terminates if a finite similarity relation exists. We show that 2D rectangular automata, which model discrete reactive systems with continuous environments, define effectively presented infinite graphs with finite similarity relations. It follows that the refinement problem and the ∀CTL* model-checking problem are decidable for 2D rectangular automata"}],"quality_controlled":"1","extern":"1","author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530","first_name":"Monika H"},{"full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger"},{"full_name":"Kopke, Peter","first_name":"Peter","last_name":"Kopke"}],"date_published":"1995-11-01T00:00:00Z","article_processing_charge":"No","date_updated":"2023-02-09T08:43:48Z","doi":"10.1109/SFCS.1995.492576","date_created":"2018-12-11T12:09:10Z","conference":{"location":"Milwaukee, WI, United States of America","start_date":"1995-10-23","name":"FOCS: Foundations of Computer Science","end_date":"1995-10-25"},"oa_version":"None","publist_id":"231","publication":"Proceedings of IEEE 36th Annual Foundations of Computer Science","title":"Computing simulations on finite and infinite graphs","publisher":"IEEE","citation":{"apa":"Henzinger, M. H., Henzinger, T. A., &#38; Kopke, P. (1995). Computing simulations on finite and infinite graphs. In <i>Proceedings of IEEE 36th Annual Foundations of Computer Science</i> (pp. 453–462). Milwaukee, WI, United States of America: IEEE. <a href=\"https://doi.org/10.1109/SFCS.1995.492576\">https://doi.org/10.1109/SFCS.1995.492576</a>","chicago":"Henzinger, Monika H, Thomas A Henzinger, and Peter Kopke. “Computing Simulations on Finite and Infinite Graphs.” In <i>Proceedings of IEEE 36th Annual Foundations of Computer Science</i>, 453–62. IEEE, 1995. <a href=\"https://doi.org/10.1109/SFCS.1995.492576\">https://doi.org/10.1109/SFCS.1995.492576</a>.","ieee":"M. H. Henzinger, T. A. Henzinger, and P. Kopke, “Computing simulations on finite and infinite graphs,” in <i>Proceedings of IEEE 36th Annual Foundations of Computer Science</i>, Milwaukee, WI, United States of America, 1995, pp. 453–462.","mla":"Henzinger, Monika H., et al. “Computing Simulations on Finite and Infinite Graphs.” <i>Proceedings of IEEE 36th Annual Foundations of Computer Science</i>, IEEE, 1995, pp. 453–62, doi:<a href=\"https://doi.org/10.1109/SFCS.1995.492576\">10.1109/SFCS.1995.492576</a>.","ista":"Henzinger MH, Henzinger TA, Kopke P. 1995. Computing simulations on finite and infinite graphs. Proceedings of IEEE 36th Annual Foundations of Computer Science. FOCS: Foundations of Computer Science, 453–462.","short":"M.H. Henzinger, T.A. Henzinger, P. Kopke, in:, Proceedings of IEEE 36th Annual Foundations of Computer Science, IEEE, 1995, pp. 453–462.","ama":"Henzinger MH, Henzinger TA, Kopke P. Computing simulations on finite and infinite graphs. In: <i>Proceedings of IEEE 36th Annual Foundations of Computer Science</i>. IEEE; 1995:453-462. doi:<a href=\"https://doi.org/10.1109/SFCS.1995.492576\">10.1109/SFCS.1995.492576</a>"},"month":"11","publication_identifier":{"isbn":["0818671831"],"issn":["0272-5428"]},"language":[{"iso":"eng"}],"status":"public","day":"01","_id":"4498","year":"1995","publication_status":"published","page":"453 - 462","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"conference"},{"date_published":"1995-01-01T00:00:00Z","author":[{"last_name":"Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"},{"last_name":"Ho","first_name":"Pei","full_name":"Ho, Pei"},{"full_name":"Wong Toi, Howard","last_name":"Wong Toi","first_name":"Howard"}],"article_processing_charge":"No","date_updated":"2022-06-10T09:33:19Z","doi":"10.1109/REAL.1995.495196 ","abstract":[{"text":"We describe a new implementation of HYTECH, a symbolic model checker for hybrid systems. Given a parametric description of an embedded system as a collection of communicating automata, HYTECH automatically computes the conditions on the parameters under which the system satisfies its safety and timing requirements. While the original HYTECH prototype was based on the symbolic algebra tool Mathematica, the new implementation is written in C++ and builds on geometric algorithms instead of formula manipulation. The new HYTECH offers a cleaner and more expressive input language, greater portability, superior performance (typically two to three orders of magnitude), and new features such as diagnostic error-trace generation. We illustrate the effectiveness of the new implementation by applying HYTECH to the automatic parametric analysis of the generic railroad crossing benchmark problem and to an active structure control algorithm","lang":"eng"}],"scopus_import":"1","extern":"1","quality_controlled":"1","publication":"Proceedings 16th IEEE Real-Time Systems Symposium","title":"HyTech: The next generation","publisher":"IEEE","conference":{"start_date":"1995-12-05","location":"Pisa, Italy","end_date":"1995-12-07","name":"RTSS: Real-Time Systems Symposium"},"date_created":"2018-12-11T12:09:10Z","oa_version":"None","publist_id":"232","status":"public","day":"01","citation":{"ista":"Henzinger TA, Ho P, Wong Toi H. 1995. HyTech: The next generation. Proceedings 16th IEEE Real-Time Systems Symposium. RTSS: Real-Time Systems Symposium, 56–65.","short":"T.A. Henzinger, P. Ho, H. Wong Toi, in:, Proceedings 16th IEEE Real-Time Systems Symposium, IEEE, 1995, pp. 56–65.","mla":"Henzinger, Thomas A., et al. “HyTech: The next Generation.” <i>Proceedings 16th IEEE Real-Time Systems Symposium</i>, IEEE, 1995, pp. 56–65, doi:<a href=\"https://doi.org/10.1109/REAL.1995.495196 \">10.1109/REAL.1995.495196 </a>.","ama":"Henzinger TA, Ho P, Wong Toi H. HyTech: The next generation. In: <i>Proceedings 16th IEEE Real-Time Systems Symposium</i>. IEEE; 1995:56-65. doi:<a href=\"https://doi.org/10.1109/REAL.1995.495196 \">10.1109/REAL.1995.495196 </a>","apa":"Henzinger, T. A., Ho, P., &#38; Wong Toi, H. (1995). HyTech: The next generation. In <i>Proceedings 16th IEEE Real-Time Systems Symposium</i> (pp. 56–65). Pisa, Italy: IEEE. <a href=\"https://doi.org/10.1109/REAL.1995.495196 \">https://doi.org/10.1109/REAL.1995.495196 </a>","chicago":"Henzinger, Thomas A, Pei Ho, and Howard Wong Toi. “HyTech: The next Generation.” In <i>Proceedings 16th IEEE Real-Time Systems Symposium</i>, 56–65. IEEE, 1995. <a href=\"https://doi.org/10.1109/REAL.1995.495196 \">https://doi.org/10.1109/REAL.1995.495196 </a>.","ieee":"T. A. Henzinger, P. Ho, and H. Wong Toi, “HyTech: The next generation,” in <i>Proceedings 16th IEEE Real-Time Systems Symposium</i>, Pisa, Italy, 1995, pp. 56–65."},"month":"01","publication_identifier":{"isbn":["0818673370"]},"language":[{"iso":"eng"}],"page":"56 - 65","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"conference","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/495196"}],"_id":"4499","year":"1995","publication_status":"published"},{"conference":{"location":"Szeged, Hungary","start_date":"1995-07-10","name":"ICALP: Automata, Languages and Programming","end_date":"1995-07-14"},"author":[{"last_name":"Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"},{"first_name":"Peter","last_name":"Kopke","full_name":"Kopke, Peter"},{"full_name":"Wong Toi, Howard","last_name":"Wong Toi","first_name":"Howard"}],"date_published":"1995-01-01T00:00:00Z","article_processing_charge":"No","date_updated":"2022-06-09T14:58:31Z","doi":"10.1007/3-540-60084-1_93","alternative_title":["LNCS"],"quality_controlled":"1","intvolume":"       944","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-60084-1_93"}],"publication_status":"published","day":"01","month":"01","language":[{"iso":"eng"}],"publication":"22nd International Colloquium on Automata, Languages and Programming ","title":"The expressive power of clocks","publisher":"Springer","date_created":"2018-12-11T12:09:10Z","oa_version":"None","publist_id":"229","abstract":[{"text":"We investigate the expressive power of timing restrictions on labeled transition systems. In particular, we show how constraints on clock variables together with a uniform liveness condition—the divergence of time—can express Büchi, Muller, Streett, Rabin, and weak and strong fairness conditions on a given labeled transition system. We then consider the effect, on both timed and time-abstract expressiveness, of varying the following parameters: time domain (discrete or dense), number of clocks, number of states, and size of constants used in timing restrictions.","lang":"eng"}],"extern":"1","volume":944,"page":"417 - 428","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"conference","_id":"4500","year":"1995","status":"public","acknowledgement":"This research was supported in part by the National Science Foundation under grant CCR-9200794, by the United States Air Force Office of Scientific Research under contract F49620-93-1-0056, by the Defense Advanced Research Projects Agency under grant NAG2-892, and by the U.S. Army Research Office through the Mathematical Sciences Institute of Cornell University, Contract Number DAAL03-91-C-0027.\r\nThe full version of this paper is available from the Department of Computer Science, Cornell University, Ithaca, NY 14853, as Technical Report TR95-1496.","citation":{"chicago":"Henzinger, Thomas A, Peter Kopke, and Howard Wong Toi. “The Expressive Power of Clocks.” In <i>22nd International Colloquium on Automata, Languages and Programming </i>, 944:417–28. Springer, 1995. <a href=\"https://doi.org/10.1007/3-540-60084-1_93\">https://doi.org/10.1007/3-540-60084-1_93</a>.","ieee":"T. A. Henzinger, P. Kopke, and H. Wong Toi, “The expressive power of clocks,” in <i>22nd International Colloquium on Automata, Languages and Programming </i>, Szeged, Hungary, 1995, vol. 944, pp. 417–428.","apa":"Henzinger, T. A., Kopke, P., &#38; Wong Toi, H. (1995). The expressive power of clocks. In <i>22nd International Colloquium on Automata, Languages and Programming </i> (Vol. 944, pp. 417–428). Szeged, Hungary: Springer. <a href=\"https://doi.org/10.1007/3-540-60084-1_93\">https://doi.org/10.1007/3-540-60084-1_93</a>","ama":"Henzinger TA, Kopke P, Wong Toi H. The expressive power of clocks. In: <i>22nd International Colloquium on Automata, Languages and Programming </i>. Vol 944. Springer; 1995:417-428. doi:<a href=\"https://doi.org/10.1007/3-540-60084-1_93\">10.1007/3-540-60084-1_93</a>","mla":"Henzinger, Thomas A., et al. “The Expressive Power of Clocks.” <i>22nd International Colloquium on Automata, Languages and Programming </i>, vol. 944, Springer, 1995, pp. 417–28, doi:<a href=\"https://doi.org/10.1007/3-540-60084-1_93\">10.1007/3-540-60084-1_93</a>.","ista":"Henzinger TA, Kopke P, Wong Toi H. 1995. The expressive power of clocks. 22nd International Colloquium on Automata, Languages and Programming . ICALP: Automata, Languages and Programming, LNCS, vol. 944, 417–428.","short":"T.A. Henzinger, P. Kopke, H. Wong Toi, in:, 22nd International Colloquium on Automata, Languages and Programming , Springer, 1995, pp. 417–428."},"publication_identifier":{"isbn":["9783540600848"]}},{"doi":"10.1145/225058.225162","date_updated":"2022-06-09T14:40:29Z","article_processing_charge":"No","date_published":"1995-01-01T00:00:00Z","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A"},{"first_name":"Peter","last_name":"Kopke","full_name":"Kopke, Peter"},{"full_name":"Puri, Anuj","first_name":"Anuj","last_name":"Puri"},{"first_name":"P.","last_name":"Varaiya","full_name":"Varaiya, P."}],"extern":"1","quality_controlled":"1","abstract":[{"text":"Hybrid automata model systems with both digital and analog components, such as embedded control programs. Many verification tasks for such programs can be expressed as reachability problems for hybrid automata. By improving on previous decidability and undecidability results, we identify the precise boundary between decidability and undecidability of the reachability problem for hybrid automata.\r\n\r\nOn the positive side, we give an (optimal) PSPACE reachability algorithm for the case of initialized rectangular automata, where all analog variables follow trajectories within piecewise-linear envelopes and are reinitialized whenever the envelope changes. Our algorithm is based on the construction of a timed automaton that contains all reachability information about a given initialized rectangular automaton. The translation has practical significance for verification, because it guarantees the termination of symbolic procedures for the reachability analysis of initialized rectangular automata. The translation also preserves the omega-languages of initialized rectangular automata with bounded nondeterminism.\r\n\r\nOn the negative side, we show that several slight generalizations of initialized rectangular automata lead to an undecidable reachability problem. In particular, we prove that the reachability problem is undecidable for timed automata augmented with a single stopwatch.","lang":"eng"}],"publisher":"ACM","title":"What's decidable about hybrid automata?","publication":"Proceedings of the 27th annual ACM symposium on Theory of computing","publist_id":"228","oa_version":"Published Version","date_created":"2018-12-11T12:09:11Z","conference":{"name":"STOC: Symposium on the Theory of Computing","end_date":"1995-06-01","location":"Las Vegas, NV, United States of America","start_date":"1995-05-29"},"day":"01","oa":1,"status":"public","acknowledgement":"We thank Howard Wong-Toi for a careful reading.\r\n","language":[{"iso":"eng"}],"publication_identifier":{"isbn":["9780897917186"]},"month":"01","citation":{"ista":"Henzinger TA, Kopke P, Puri A, Varaiya P. 1995. What’s decidable about hybrid automata? Proceedings of the 27th annual ACM symposium on Theory of computing. STOC: Symposium on the Theory of Computing, 373–382.","mla":"Henzinger, Thomas A., et al. “What’s Decidable about Hybrid Automata?” <i>Proceedings of the 27th Annual ACM Symposium on Theory of Computing</i>, ACM, 1995, pp. 373–82, doi:<a href=\"https://doi.org/10.1145/225058.225162\">10.1145/225058.225162</a>.","short":"T.A. Henzinger, P. Kopke, A. Puri, P. Varaiya, in:, Proceedings of the 27th Annual ACM Symposium on Theory of Computing, ACM, 1995, pp. 373–382.","ama":"Henzinger TA, Kopke P, Puri A, Varaiya P. What’s decidable about hybrid automata? In: <i>Proceedings of the 27th Annual ACM Symposium on Theory of Computing</i>. ACM; 1995:373-382. doi:<a href=\"https://doi.org/10.1145/225058.225162\">10.1145/225058.225162</a>","apa":"Henzinger, T. A., Kopke, P., Puri, A., &#38; Varaiya, P. (1995). What’s decidable about hybrid automata? In <i>Proceedings of the 27th annual ACM symposium on Theory of computing</i> (pp. 373–382). Las Vegas, NV, United States of America: ACM. <a href=\"https://doi.org/10.1145/225058.225162\">https://doi.org/10.1145/225058.225162</a>","ieee":"T. A. Henzinger, P. Kopke, A. Puri, and P. Varaiya, “What’s decidable about hybrid automata?,” in <i>Proceedings of the 27th annual ACM symposium on Theory of computing</i>, Las Vegas, NV, United States of America, 1995, pp. 373–382.","chicago":"Henzinger, Thomas A, Peter Kopke, Anuj Puri, and P. Varaiya. “What’s Decidable about Hybrid Automata?” In <i>Proceedings of the 27th Annual ACM Symposium on Theory of Computing</i>, 373–82. ACM, 1995. <a href=\"https://doi.org/10.1145/225058.225162\">https://doi.org/10.1145/225058.225162</a>."},"type":"conference","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"373 - 382","publication_status":"published","year":"1995","main_file_link":[{"open_access":"1","url":"https://dl.acm.org/doi/10.1145/225058.225162"}],"_id":"4502"},{"quality_controlled":"1","article_processing_charge":"No","date_updated":"2022-06-09T14:21:08Z","doi":"10.1007/3-540-60084-1_85","alternative_title":["LNCS"],"date_published":"1995-01-01T00:00:00Z","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A"}],"conference":{"name":"ICALP: Automata, Languages and Programming","end_date":"1995-07-14","location":"Szeged, Hungary","start_date":"1995-07-10"},"month":"01","language":[{"iso":"eng"}],"day":"01","publication_status":"published","intvolume":"       944","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-60084-1_85"}],"extern":"1","abstract":[{"lang":"eng","text":"The analysis, verification, and control of hybrid automata with finite bisimulations can be reduced to finite-state problems. We advocate a time-abstract, phase-based methodology for checking if a given hybrid automaton has a finite bisimulation. First, we factor the automaton into two components, a boolean automaton with a discrete dynamics on the finite state space B m and a euclidean automaton with a continuous dynamics on the infinite state space  n . Second, we investigate the phase portrait of the euclidean component. In this fashion, we obtain new decidability results for hybrid systems as well as new, uniform proofs of known decidability results."}],"publist_id":"212","date_created":"2018-12-11T12:09:16Z","oa_version":"None","publisher":"Springer","publication":"22nd International Colloquium on Automata, Languages and Programming ","title":"Hybrid automata with finite bisimulations","publication_identifier":{"isbn":["9783540600848"]},"citation":{"apa":"Henzinger, T. A. (1995). Hybrid automata with finite bisimulations. In <i>22nd International Colloquium on Automata, Languages and Programming </i> (Vol. 944, pp. 324–335). Szeged, Hungary: Springer. <a href=\"https://doi.org/10.1007/3-540-60084-1_85\">https://doi.org/10.1007/3-540-60084-1_85</a>","chicago":"Henzinger, Thomas A. “Hybrid Automata with Finite Bisimulations.” In <i>22nd International Colloquium on Automata, Languages and Programming </i>, 944:324–35. Springer, 1995. <a href=\"https://doi.org/10.1007/3-540-60084-1_85\">https://doi.org/10.1007/3-540-60084-1_85</a>.","ieee":"T. A. Henzinger, “Hybrid automata with finite bisimulations,” in <i>22nd International Colloquium on Automata, Languages and Programming </i>, Szeged, Hungary, 1995, vol. 944, pp. 324–335.","mla":"Henzinger, Thomas A. “Hybrid Automata with Finite Bisimulations.” <i>22nd International Colloquium on Automata, Languages and Programming </i>, vol. 944, Springer, 1995, pp. 324–35, doi:<a href=\"https://doi.org/10.1007/3-540-60084-1_85\">10.1007/3-540-60084-1_85</a>.","ista":"Henzinger TA. 1995. Hybrid automata with finite bisimulations. 22nd International Colloquium on Automata, Languages and Programming . ICALP: Automata, Languages and Programming, LNCS, vol. 944, 324–335.","short":"T.A. Henzinger, in:, 22nd International Colloquium on Automata, Languages and Programming , Springer, 1995, pp. 324–335.","ama":"Henzinger TA. Hybrid automata with finite bisimulations. In: <i>22nd International Colloquium on Automata, Languages and Programming </i>. Vol 944. Springer; 1995:324-335. doi:<a href=\"https://doi.org/10.1007/3-540-60084-1_85\">10.1007/3-540-60084-1_85</a>"},"acknowledgement":"This research was supported in part by the NSF grant CCR-9200794, by the AFOSR contract F49620-93-1-0056, and by the DARPA grant NAG2-892.\r\n","status":"public","year":"1995","_id":"4518","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"conference","volume":944,"page":"324 - 335"},{"author":[{"last_name":"Kaneko","first_name":"Takeshi","full_name":"Kaneko, Takeshi"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"date_published":"1994-05-01T00:00:00Z","article_processing_charge":"No","date_updated":"2022-06-09T12:22:16Z","doi":"10.1016/0306-4522(94)90215-1","scopus_import":"1","quality_controlled":"1","intvolume":"        60","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0306452294902151?via%3Dihub"}],"publication_status":"published","pmid":1,"day":"01","month":"05","language":[{"iso":"eng"}],"publication":"Neuroscience","title":"Morphological and chemical characteristics of substance P receptor immunoreactive neurons in the rat neocortex","publisher":"Elsevier","date_created":"2018-12-11T11:57:58Z","oa_version":"None","publist_id":"4413","abstract":[{"text":"Substance P receptor-expressing neurons in the rat cerebral neocortex were examined by single- and double-immunolabeling methods with an affinity-purified specific antibody to substance P receptor. Substance P receptor immunoreactivity was observed exclusively in non-pyramidal neurons. About a quarter of these substance P receptor-positive neocortical neurons showed intense immunoreactivity, and the other three quarters displayed weak substance P receptor immunoreactivity. The neurons showing intense substance P receptor immunoreactivity were large multipolar cells with a few long aspiny or sparsely-spiny dendrites, and were scattered throughout the neocortical layers except for layer I, and also in the underlying white matter. The weakly immunoreactive neurons were medium-sized multipolar cells with oval to round somata and aspiny varicose dendrites, and were distributed in all cortical layers with a bias to layers II-III and the superficial part of layer V. The double-immunofluorescence study revealed that almost all substance P receptor-positive neurons were immunoreactive for GABA, but negative for glutaminase. Substance P receptor immunoreactivity in GABAergic neocortical neurons were further examined by the double-immunofluorescence method with antibodies to markers for subgroups of GABAergic neurons. Somatostatin immunoreactivity was found in 89% of neurons with intense substance P receptor immunoreactivity, and in 1.5% of neurons with weak substance P receptor immunoreactivity. Neuropeptide Y immunoreactivity was also observed in 92% of neurons with intense immunoreactivity for substance P receptor, and in 1.6% of neurons with weak immunoreactivity for substance P receptor. In contrast, parvalbumin immunoreactivity was seen in 1.3% of neurons with intense substance P receptor immunoreactivity, and in 59% of weak substance P receptor immunoreactivity. Calbindin D28k immunoreactivity was found in 12 and 19% of neurons, respectively, with weak and intense immunoreactivities for substance P receptor. Virtually no cells showing substance P receptor immunoreactivity displayed immunoreactivity for vasoactive intestinal polypeptide or choline acetyltransferase. These results indicate that the neocortical neurons expressing substance P receptor constitute a subpopulation of GABAergic non-pyramidal cells, and are segregated into neurons with intense immunoreactivity and those with weak immunoreactivity for substance P receptor; the vast majority of neurons with intense substance P receptor immunoreactivity contain somatostatin and neuropeptide Y, and the majority of neurons with weak substance P receptor immunoreactivity have parvalbumin.","lang":"eng"}],"extern":"1","volume":60,"page":"199 - 211","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"2488","year":"1994","acknowledgement":"We are grateful for photographic help of Mr A. Uesugi, and the support of Drs S. Fukuchi, T. Fukuda, R. Hayashi, M. Katsurada, Y. Kitani, K. Kumagai, H. Kuroda, H. Matsubara, H. Matsushima, C. Minakuchi, M. Nishio, G. Niwa, H. Ckla, M. Ohbayashi, S. Ohbayashi, H. Ohtsuka, S. Tamaki, E. Watanabe, K. Yoshino and Y. Yoshino. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas 05248207 and 05267104, and Scientific Research (B) 05454658 and (C) 05680658 from the Ministry of Education, Science and Culture of Japan.","status":"public","issue":"1","article_type":"original","external_id":{"pmid":["8052413"]},"citation":{"mla":"Kaneko, Takeshi, et al. “Morphological and Chemical Characteristics of Substance P Receptor Immunoreactive Neurons in the Rat Neocortex.” <i>Neuroscience</i>, vol. 60, no. 1, Elsevier, 1994, pp. 199–211, doi:<a href=\"https://doi.org/10.1016/0306-4522(94)90215-1\">10.1016/0306-4522(94)90215-1</a>.","short":"T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience 60 (1994) 199–211.","ista":"Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Morphological and chemical characteristics of substance P receptor immunoreactive neurons in the rat neocortex. Neuroscience. 60(1), 199–211.","ama":"Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Morphological and chemical characteristics of substance P receptor immunoreactive neurons in the rat neocortex. <i>Neuroscience</i>. 1994;60(1):199-211. doi:<a href=\"https://doi.org/10.1016/0306-4522(94)90215-1\">10.1016/0306-4522(94)90215-1</a>","apa":"Kaneko, T., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1994). Morphological and chemical characteristics of substance P receptor immunoreactive neurons in the rat neocortex. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/0306-4522(94)90215-1\">https://doi.org/10.1016/0306-4522(94)90215-1</a>","ieee":"T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Morphological and chemical characteristics of substance P receptor immunoreactive neurons in the rat neocortex,” <i>Neuroscience</i>, vol. 60, no. 1. Elsevier, pp. 199–211, 1994.","chicago":"Kaneko, Takeshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Morphological and Chemical Characteristics of Substance P Receptor Immunoreactive Neurons in the Rat Neocortex.” <i>Neuroscience</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0306-4522(94)90215-1\">https://doi.org/10.1016/0306-4522(94)90215-1</a>."},"publication_identifier":{"issn":["0306-4522"]}},{"publication":"Journal of Comparative Neurology","title":"Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats","publisher":"Wiley-Blackwell","date_created":"2018-12-11T11:57:58Z","oa_version":"None","publist_id":"4412","abstract":[{"lang":"eng","text":"Five N-methyl-D-aspartate (NMDA) receptor subunits have been identified thus far: NR1, NR2A, NR2B, NR2C, and NR2D. Here, we have analyzed the expression patterns of mRNAs for the NMDA receptor subunits in the developing and adult rats by in situ hybridization. The developmental changes of the expression patterns were most salient in the cerebellum. In the external granular layer, hybridization signals of mRNAs for NR1, NR2A, NR2B, and NR2C appeared by postnatal day 3, but no NR2D mRNA was expressed at any developmental stage examined. The NR1 mRNA was expressed in all cerebellar neurons at all developmental stages examined. The signals for the NR2A mRNA appeared in Purkinje cells and granule cells during the second postnatal week. The signals for the NR2B mRNA in granule cells were seen transiently during the first 2 weeks after birth. The signals for NR2C mRNA appeared in granule cells and glial cells during the second postnatal week. The signals for NR2D mRNA appeared transiently in Purkinje cells during the first 8 postnatal days; in adult rats, these were seen in stellate and Golgi cells. In the cerebellar nuclei, mRNAs for NR1, NR2A, NR2B, and NR2D were more or less expressed on postnatal day 0, while expression signals for the NR2C mRNA were first detected in postnatal day 14. Thus, the most conspicuous changes of expression patterns were observed in the cerebellar cortex during the first 2 weeks after birth, when development and maturation of the cerebellum proceed most rapidly."}],"extern":"1","volume":347,"page":"150 - 160","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","_id":"2489","year":"1994","acknowledgement":"We are grateful to  Mr.  Akira  Uesugi for photographic help and for the support of Drs. Satoru Fukuchi, Toshio Fukuda, Ritsu Hayashi, Mizuho Katsurada, Yutaka Kitani, Keiko Kumagai,  Toshihiko Kuroda,  Hiroshi  Matsubara, Hiroshi Matsushima, Chisato Minakuchi, Masatoshi Nishio, Gonpei  Niwa Hajime Oda, Masahiko  Ohbayashi, Sei-ichi Ohbayashi, Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watan- abe, Kazuo Yoshino, and Toshiaki Yoshino. This work was supported in part by research grants from the Ministry of Education, Science and Culture of Japan.","status":"public","issue":"1","external_id":{"pmid":["7798379"]},"article_type":"original","citation":{"ama":"Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. <i>Journal of Comparative Neurology</i>. 1994;347(1):150-160. doi:<a href=\"https://doi.org/10.1002/cne.903470112\">10.1002/cne.903470112</a>","ista":"Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N. 1994. Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. Journal of Comparative Neurology. 347(1), 150–160.","short":"C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 347 (1994) 150–160.","mla":"Akazawa, Chihiro, et al. “Differential Expression of Five N-Methyl-D-Aspartate Receptor Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” <i>Journal of Comparative Neurology</i>, vol. 347, no. 1, Wiley-Blackwell, 1994, pp. 150–60, doi:<a href=\"https://doi.org/10.1002/cne.903470112\">10.1002/cne.903470112</a>.","chicago":"Akazawa, Chihiro, Ryuichi Shigemoto, Yasumasa Bessho, Shigetada Nakanishi, and Noboru Mizuno. “Differential Expression of Five N-Methyl-D-Aspartate Receptor Subunit MRNAs in the Cerebellum of Developing and Adult Rats.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1994. <a href=\"https://doi.org/10.1002/cne.903470112\">https://doi.org/10.1002/cne.903470112</a>.","ieee":"C. Akazawa, R. Shigemoto, Y. Bessho, S. Nakanishi, and N. Mizuno, “Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats,” <i>Journal of Comparative Neurology</i>, vol. 347, no. 1. Wiley-Blackwell, pp. 150–160, 1994.","apa":"Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., &#38; Mizuno, N. (1994). Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903470112\">https://doi.org/10.1002/cne.903470112</a>"},"publication_identifier":{"issn":["0021-9967"]},"date_published":"1994-09-01T00:00:00Z","author":[{"last_name":"Akazawa","first_name":"Chihiro","full_name":"Akazawa, Chihiro"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"first_name":"Yasumasa","last_name":"Bessho","full_name":"Bessho, Yasumasa"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"article_processing_charge":"No","date_updated":"2022-06-09T12:11:20Z","doi":"10.1002/cne.903470112","scopus_import":"1","quality_controlled":"1","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903470112"}],"intvolume":"       347","publication_status":"published","pmid":1,"day":"01","month":"09","language":[{"iso":"eng"}]},{"_id":"2490","year":"1994","volume":62,"page":"919 - 928","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","citation":{"ieee":"Y. Sugimoto <i>et al.</i>, “Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system,” <i>Neuroscience</i>, vol. 62, no. 3. Elsevier, pp. 919–928, 1994.","chicago":"Sugimoto, Yukihiko, Ryuichi Shigemoto, Tsunehisa Namba, Manabu Negishi, Noboru Mizuno, Shuh Narumiya, and Atsushi Ichikawa. “Distribution of the Messenger Rna for the Prostaglandin e Receptor Subtype Ep3 in the Mouse Nervous System.” <i>Neuroscience</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0306-4522(94)90483-9\">https://doi.org/10.1016/0306-4522(94)90483-9</a>.","apa":"Sugimoto, Y., Shigemoto, R., Namba, T., Negishi, M., Mizuno, N., Narumiya, S., &#38; Ichikawa, A. (1994). Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system. <i>Neuroscience</i>. Elsevier. <a href=\"https://doi.org/10.1016/0306-4522(94)90483-9\">https://doi.org/10.1016/0306-4522(94)90483-9</a>","ama":"Sugimoto Y, Shigemoto R, Namba T, et al. Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system. <i>Neuroscience</i>. 1994;62(3):919-928. doi:<a href=\"https://doi.org/10.1016/0306-4522(94)90483-9\">10.1016/0306-4522(94)90483-9</a>","ista":"Sugimoto Y, Shigemoto R, Namba T, Negishi M, Mizuno N, Narumiya S, Ichikawa A. 1994. Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system. Neuroscience. 62(3), 919–928.","short":"Y. Sugimoto, R. Shigemoto, T. Namba, M. Negishi, N. Mizuno, S. Narumiya, A. Ichikawa, Neuroscience 62 (1994) 919–928.","mla":"Sugimoto, Yukihiko, et al. “Distribution of the Messenger Rna for the Prostaglandin e Receptor Subtype Ep3 in the Mouse Nervous System.” <i>Neuroscience</i>, vol. 62, no. 3, Elsevier, 1994, pp. 919–28, doi:<a href=\"https://doi.org/10.1016/0306-4522(94)90483-9\">10.1016/0306-4522(94)90483-9</a>."},"publication_identifier":{"issn":["0306-4522"]},"status":"public","acknowledgement":"This work was supported in part by Grants-in-aid for Scientific Research 05404020, 04255103. 05771975, 05671816 and 05454568 from the Ministry of Education, Science and Culture of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation. We are grateful to Mr Akira Uesugi for photographic help. We also thank Drs Chihiro Akazawa, Hitoshi Ohishi and Masabumi Minami for helpful discussions. ","issue":"3","article_type":"original","external_id":{"pmid":["7870313"]},"date_created":"2018-12-11T11:57:58Z","oa_version":"None","publist_id":"4411","publication":"Neuroscience","title":"Distribution of the messenger rna for the prostaglandin e receptor subtype ep3 in the mouse nervous system","publisher":"Elsevier","abstract":[{"text":"Distribution of the messenger RNA for the prostaglandin E receptor subtype EP3 was investigated by in situ hybridization in the nervous system of the mouse. The hybridization signals for EP3 were widely distributed in the brain and sensory ganglia and specifically localized to neurons. In the dorsal root and trigeminal ganglia, about half of the neurons were labeled intensely. In the brain, intensely labeled neurons were found in Ammon's horn, the preoptic nuclei, lateral hypothalamic area, dorsomedial hypothalamic nucleus, lateral mammillary nucleus, entopeduncular nucleus, substantia nigra pars compacta, locus coeruleus and raphe nuclei. Moderately labeled neurons were seen in the mitral cell layer of the main olfactory bulb, layer V of the entorhinal and parasubicular cortices, layers V and VI of the cerebral neocortex, nuclei of the diagonal band, magnocellular preoptic nucleus, globus pallidus and lateral parabrachial nucleus. In the thalamus, moderately labeled neurons were distributed in the anterior, ventromedial, laterodorsal, paraventricular and central medial nuclei. Based on these distributions, we suggest that EP3 not only mediates prostaglandin E2 signals evoked by blood-borne cytokines in the areas poor in the blood-brain barrier, but also responds to those formed intrinsically within the brain to modulate various neuronal activities. Possible EP3 actions are discussed in relation to the reported neuronal activities of prostaglandin E2 in the brain.","lang":"eng"}],"extern":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0306452294904839?via%3Dihub"}],"intvolume":"        62","publication_status":"published","month":"10","language":[{"iso":"eng"}],"pmid":1,"day":"01","quality_controlled":"1","author":[{"full_name":"Sugimoto, Yukihiko","first_name":"Yukihiko","last_name":"Sugimoto"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Namba, Tsunehisa","first_name":"Tsunehisa","last_name":"Namba"},{"full_name":"Negishi, Manabu","first_name":"Manabu","last_name":"Negishi"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"},{"full_name":"Narumiya, Shuh","first_name":"Shuh","last_name":"Narumiya"},{"full_name":"Ichikawa, Atsushi","last_name":"Ichikawa","first_name":"Atsushi"}],"date_published":"1994-10-01T00:00:00Z","article_processing_charge":"No","date_updated":"2022-06-09T11:56:23Z","doi":"10.1016/0306-4522(94)90483-9"},{"page":"71 - 80","volume":71,"type":"book_chapter","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","_id":"2545","year":"1994","status":"public","external_id":{"pmid":["8032174"]},"citation":{"ama":"Nakanishi S, Masu M, Bessho Y, Nakajima Y, Hayashi Y, Shigemoto R. Molecular diversity of glutamate receptors and their physiological functions. In: <i>Experientia Supplementum</i>. Vol 71. Birkhäuser; 1994:71-80. doi:<a href=\"https://doi.org/10.1007/978-3-0348-7330-7_8\">10.1007/978-3-0348-7330-7_8</a>","mla":"Nakanishi, Shigetada, et al. “Molecular Diversity of Glutamate Receptors and Their Physiological Functions.” <i>Experientia Supplementum</i>, vol. 71, Birkhäuser, 1994, pp. 71–80, doi:<a href=\"https://doi.org/10.1007/978-3-0348-7330-7_8\">10.1007/978-3-0348-7330-7_8</a>.","short":"S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi, R. Shigemoto, in:, Experientia Supplementum, Birkhäuser, 1994, pp. 71–80.","ista":"Nakanishi S, Masu M, Bessho Y, Nakajima Y, Hayashi Y, Shigemoto R. 1994.Molecular diversity of glutamate receptors and their physiological functions. In: Experientia Supplementum. vol. 71, 71–80.","chicago":"Nakanishi, Shigetada, Masayuki Masu, Yasumasa Bessho, Yoshiaki Nakajima, Yasunori Hayashi, and Ryuichi Shigemoto. “Molecular Diversity of Glutamate Receptors and Their Physiological Functions.” In <i>Experientia Supplementum</i>, 71:71–80. Birkhäuser, 1994. <a href=\"https://doi.org/10.1007/978-3-0348-7330-7_8\">https://doi.org/10.1007/978-3-0348-7330-7_8</a>.","ieee":"S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi, and R. Shigemoto, “Molecular diversity of glutamate receptors and their physiological functions,” in <i>Experientia Supplementum</i>, vol. 71, Birkhäuser, 1994, pp. 71–80.","apa":"Nakanishi, S., Masu, M., Bessho, Y., Nakajima, Y., Hayashi, Y., &#38; Shigemoto, R. (1994). Molecular diversity of glutamate receptors and their physiological functions. In <i>Experientia Supplementum</i> (Vol. 71, pp. 71–80). Birkhäuser. <a href=\"https://doi.org/10.1007/978-3-0348-7330-7_8\">https://doi.org/10.1007/978-3-0348-7330-7_8</a>"},"publication_identifier":{"isbn":["9783034873321"]},"title":"Molecular diversity of glutamate receptors and their physiological functions","publication":"Experientia Supplementum","publisher":"Birkhäuser","oa_version":"None","date_created":"2018-12-11T11:58:18Z","publist_id":"4352","abstract":[{"text":"Glutamate receptors play an important role in many integrative brain functions and in neuronal development. We report the molecular diversity of NMDA receptors and metabotropic glutamate receptors on the basis of our studies of molecular cloning and characterization of the diverse members of these receptors. The NMDA receptors consist of two distinct types of subunits. NMDAR1 possesses all properties characteristic of the NMDA receptor-channel complex, whereas the four NMDAR2 subunits, termed NMDAR2A-2D, show no channel activity but potentiate the NMDAR1 activity and confer functional variability by different heteromeric formations. The NMDA receptor subunits are considerably divergent from the other ligand-gated ion channels, and the structural architecture of these subunits remains elusive. The mGluRs form a family of at least seven different subtypes termed mGluR1-mGluR7. These receptor subtypes have, seven transmembrane segments and possess a large extracellular domain at their N-terminal regions. The seven mGluR subtypes are classified into three subgroups according to their sequence similarities, signal transduction mechanisms and agonist selectivities: mGluR1/mGluR5, mGluR2/mGluR3 and mGluR4/mGluR6/mGluR7. On the basis of our knowledge of the molecular diversity of the NMDA receptors and mGluRs, we have studied the physiological roles of individual receptor subunits or subtypes. We have shown that K(+)-induced depolarization or NMDA treatment in primary cultures of neonatal cerebellar granule cells induces the functional NMDA receptor and specifically up-regulates NMDAR2A mRNA among the multiple NMDA receptor subunits through the increase in resting intracellular Ca2+ concentrations. Our study demonstrates that the regulation of the specific NMDA receptor subunit mRNA governs the NMDA receptor induction that is thought to play an important role in granule cell survival and death. Analysis of an agonist selectivity and an expression pattern of mGluR6 has indicated that mGluR6 is responsible for synaptic neurotransmission from photoreceptor cells to ON-bipolar cells in the visual system. We have also investigated the function of mGluR2 in granule cells of the accessory olfactory bulb by combining immunoelectron-microscopic analysis with slice-patch recordings on the basis of the identification of a new agonist selective for this receptor subtype. Our results demonstrate that mGluR2 is present at the presynaptic site of granule cells and modulates inhibitory GABA transmission from granule cells to mitral cells. This finding indicates that the mGluR2 activation relieves excited mitral cells from GABA inhibition but maintains the lateral inhibition of unexcited mitral cells, thus resulting in enhancement of the signal-to-noise ratio between the excited mitral cells and their neighboring unexcited mitral cells.","lang":"eng"}],"extern":"1","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/978-3-0348-7330-7_8"}],"intvolume":"        71","publication_status":"published","pmid":1,"day":"01","language":[{"iso":"eng"}],"month":"01","author":[{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"full_name":"Masu, Masayuki","first_name":"Masayuki","last_name":"Masu"},{"full_name":"Bessho, Yasumasa","last_name":"Bessho","first_name":"Yasumasa"},{"full_name":"Nakajima, Yoshiaki","first_name":"Yoshiaki","last_name":"Nakajima"},{"full_name":"Hayashi, Yasunori","first_name":"Yasunori","last_name":"Hayashi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"}],"date_published":"1994-01-01T00:00:00Z","date_updated":"2022-06-09T10:08:24Z","doi":"10.1007/978-3-0348-7330-7_8","article_processing_charge":"No","scopus_import":"1","quality_controlled":"1"},{"conference":{"name":"Unknown (0388-6107)"},"date_created":"2018-12-11T11:58:19Z","publist_id":"4350","title":"Induction mechanism of long term depression in cultured Purkinje neurons","publisher":"Biomedical Research Foundation","abstract":[{"text":"The induction mechanism of cerebellar long term depression (LTD) has been analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we demonstrated that an increase in postsynaptic Ca together with glutamate application is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells. It has also been shown that one subtype of genetically defined metabotropic glutamate receptor, mGluR1, is involved in the LTD induction. We raised antibodies which specifically recognized mGluR1 and inactivated its function. The antibodies suppressed the LTD induction in the cultured Purkinje cells.","lang":"eng"}],"extern":1,"quality_controlled":0,"date_published":"1994-01-01T00:00:00Z","author":[{"last_name":"Hirano","first_name":"Tomoo","full_name":"Hirano, Tomoo"},{"first_name":"Keizo","last_name":"Kasono","full_name":"Kasono, Keizo"},{"full_name":"Ryuichi Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"}],"date_updated":"2021-01-12T06:58:10Z","alternative_title":["Biomedical Research"],"intvolume":"        15","_id":"2548","publication_status":"published","year":"1994","page":"79 - 81","volume":15,"type":"conference","citation":{"ama":"Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research Foundation; 1994:79-81.","ista":"Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical Research, vol. 15, 79–81.","short":"T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research Foundation, 1994, pp. 79–81.","mla":"Hirano, Tomoo, et al. <i>Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons</i>. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994, pp. 79–81.","ieee":"T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism of long term depression in cultured Purkinje neurons,” presented at the Unknown (0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81.","chicago":"Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi. “Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81. Biomedical Research Foundation, 1994.","apa":"Hirano, T., Kasono, K., Shigemoto, R., &#38; Nakanishi, S. (1994). Induction mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81). Presented at the Unknown (0388-6107), Biomedical Research Foundation."},"month":"01","status":"public","day":"01","issue":"SUPPL. 1"},{"year":"1994","_id":"2549","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":347,"page":"249 - 274","publication_identifier":{"issn":["0021-9967"]},"citation":{"ama":"Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. <i>Journal of Comparative Neurology</i>. 1994;347(2):249-274. doi:<a href=\"https://doi.org/10.1002/cne.903470208\">10.1002/cne.903470208</a>","ista":"Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. Journal of Comparative Neurology. 347(2), 249–274.","mla":"Nakaya, Yoshifumi, et al. “Immunohistochemical Localization of Substance P Receptor in the Central Nervous System of the Adult Rat.” <i>Journal of Comparative Neurology</i>, vol. 347, no. 2, Wiley-Blackwell, 1994, pp. 249–74, doi:<a href=\"https://doi.org/10.1002/cne.903470208\">10.1002/cne.903470208</a>.","short":"Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 347 (1994) 249–274.","ieee":"Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat,” <i>Journal of Comparative Neurology</i>, vol. 347, no. 2. Wiley-Blackwell, pp. 249–274, 1994.","chicago":"Nakaya, Yoshifumi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the Central Nervous System of the Adult Rat.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1994. <a href=\"https://doi.org/10.1002/cne.903470208\">https://doi.org/10.1002/cne.903470208</a>.","apa":"Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1994). Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903470208\">https://doi.org/10.1002/cne.903470208</a>"},"issue":"2","external_id":{"pmid":["7814667"]},"article_type":"original","status":"public","acknowledgement":"We are grateful for photographic help of Mr. A. Uesugi and the support of Drs. M. Arakawa, S. Fukuchi, T., Fukuda, R. Hayashi, S. Hayashi, S. Imai, M. Katsurada, Y. Kitani, K. Kumagai, H. Kuroda, T. Kuroda, H. Matsubara, J. Matsuoka, H. Matsushima, M. Nishio, G. Niwa, H. Oda, M. Ohbayashi, S. Ohbayashi, H. Ohtsuka, S. Tamaki,  E. Watanabe, and Y. Yoshino. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas 05248207 and 05267104 and Scientific  Research (B) 05454658 and (C) 05680658 from the Ministry of Education, Science and Culture of Japan. ","publist_id":"4349","date_created":"2018-12-11T11:58:20Z","oa_version":"None","publisher":"Wiley-Blackwell","publication":"Journal of Comparative Neurology","title":"Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat","extern":"1","abstract":[{"lang":"eng","text":"In an attempt to reveal the function sites of substance P (SP) in the central nervous system (CNS), the distribution of SP receptor (SPR) was immunocytochemically investigated in adult rat and compared with that of SP- positive fibers. SPR-like immunoreactivity (LI) was mostly localized to neuronal cell bodies and dendrites. Neurons with intense SPR-LI were distributed densely in the cortical amygdaloid nucleus, hilus of the dentate gyrus, locus ceruleus, rostral half of the ambiguus nucleus, and intermediolateral nucleus of the thoracic cord; moderately in the caudatoputamen, nucleus accumbens, olfactory tubercle, median, pontine, and magnus raphe nuclei, laminae I and III of the caudal subnucleus of the spinal trigeminal nucleus, and lamina I of the spinal cord; and sparsely in the cerebral cortex, basal nucleus of Meynert, claustrum, gigantocellular reticular nucleus, and lobules IX and X of the cerebellar vermis. Neurons with weak to moderate SPR-LI were distributed more widely throughout the CNS. The regional patterns of distribution of SPR-LI were not necessarily the same as those of SP-positive fibers. The entopeduncular nucleus, substantia nigra, and lateral part of the interpeduncular nucleus showed intense SP-LI but displayed almost no SPR-LI. Conversely, the hilus of the dentate gyrus, anterodorsal thalamic nucleus, central nucleus of the inferior colliculus, and dorsal tegmental nucleus showed intense to moderate SPR-LI but contained few axons with SP-LI. These findings confirmed the presence of the 'mismatch' problem between SP and SPR localizations. However, the distribution of SPR- LI was quite consistent with that of the SP-binding activity, which has been studied via autoradiography. This indicates that the sites of SPR-LI revealed in the present study represent most, if not all, sites of SP-binding activity."}],"publication_status":"published","main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/10.1002/cne.903470208"}],"intvolume":"       347","month":"09","language":[{"iso":"eng"}],"day":"08","pmid":1,"quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","date_updated":"2022-06-09T09:25:30Z","doi":"10.1002/cne.903470208","date_published":"1994-09-08T00:00:00Z","author":[{"first_name":"Yoshifumi","last_name":"Nakaya","full_name":"Nakaya, Yoshifumi"},{"last_name":"Kaneko","first_name":"Takeshi","full_name":"Kaneko, Takeshi"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}]},{"citation":{"apa":"Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1994). Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology. <a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">https://doi.org/10.1016/S0021-9258(17)42247-2</a>","ieee":"N. Okamoto <i>et al.</i>, “Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction,” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2. American Society for Biochemistry and Molecular Biology, pp. 1231–1236, 1994.","chicago":"Okamoto, Naoyuki, Seiji Hori, Chihiro Akazawa, Yasunori Hayashi, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.” <i>Journal of Biological Chemistry</i>. American Society for Biochemistry and Molecular Biology, 1994. <a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">https://doi.org/10.1016/S0021-9258(17)42247-2</a>.","short":"N. Okamoto, S. Hori, C. Akazawa, Y. Hayashi, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal of Biological Chemistry 269 (1994) 1231–1236.","ista":"Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S. 1994. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Journal of Biological Chemistry. 269(2), 1231–1236.","mla":"Okamoto, Naoyuki, et al. “Molecular Characterization of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.” <i>Journal of Biological Chemistry</i>, vol. 269, no. 2, American Society for Biochemistry and Molecular Biology, 1994, pp. 1231–36, doi:<a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">10.1016/S0021-9258(17)42247-2</a>.","ama":"Okamoto N, Hori S, Akazawa C, et al. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. <i>Journal of Biological Chemistry</i>. 1994;269(2):1231-1236. doi:<a href=\"https://doi.org/10.1016/S0021-9258(17)42247-2\">10.1016/S0021-9258(17)42247-2</a>"},"issue":"2","external_id":{"pmid":["8288585"]},"oa":1,"acknowledgement":"We are grateful to Akira Uesugi for photographic assistance.","status":"public","year":"1994","_id":"2550","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":269,"page":"1231 - 1236","extern":"1","abstract":[{"lang":"eng","text":"A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic receptor (mGluR) family and by the subsequent screening of a rat forebrain cDNA library. The cloned mGluR7 subtype consists of 915 amino acid residues and exhibits a structural architecture common to the mGluR family with a large extracellular domain preceding the seven putative membrane-spanning domains. mGluR7 shows the highest sequence similarity to mGluR4 and mGluR6 among the members of the mGluR family. Similar to mGluR4 and mGluR6, mGluR7 inhibits forskolin- stimulated cyclic AMP accumulation in response to agonist interaction and potently reacts with L-2-amino-4-phosphonobutyrate and L-serine-O-phosphate in Chinese hamster ovary cells transfected with the cloned cDNA. RNA blot and in situ hybridization analyses of mGluR7 mRNA indicated that it is widely expressed in many neuronal cells of the central nervous system and is thus different from the more limitedly expressed mGluR4 or mGluR6 mRNA. mGluR7 together with mGluR4 thus corresponds to the putative L-2-amino-4- phosphonobutyrate receptor which plays an important role in modulation of glutamate transmission in the central nervous system."}],"publist_id":"4348","date_created":"2018-12-11T11:58:20Z","oa_version":"None","publisher":"American Society for Biochemistry and Molecular Biology","publication":"Journal of Biological Chemistry","title":"Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction","month":"01","language":[{"iso":"eng"}],"day":"14","pmid":1,"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0021925817422472?via%3Dihub"}],"intvolume":"       269","quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","date_updated":"2022-06-08T15:11:44Z","doi":"10.1016/S0021-9258(17)42247-2","date_published":"1994-01-14T00:00:00Z","author":[{"last_name":"Okamoto","first_name":"Naoyuki","full_name":"Okamoto, Naoyuki"},{"full_name":"Hori, Seiji","last_name":"Hori","first_name":"Seiji"},{"full_name":"Akazawa, Chihiro","last_name":"Akazawa","first_name":"Chihiro"},{"full_name":"Hayashi, Yasunori","last_name":"Hayashi","first_name":"Yasunori"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}]},{"abstract":[{"lang":"eng","text":"Expression patterns of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7 mRNAs were quite different from that of mGluR6 mRNA which was expressed at the outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell bodies of the ganglion cells, but not in the inner or outer nuclear layer. The expression of mGluR7 mRNA was observed throughout the entire region of the inner nuclear layer and on the cell bodies of the ganglion cells."}],"extern":"1","date_created":"2018-12-11T11:58:21Z","oa_version":"None","publist_id":"4346","publication":"Neuroscience Letters","title":"Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina","publisher":"Elsevier","citation":{"apa":"Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1994). Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">https://doi.org/10.1016/0304-3940(94)90602-5</a>","chicago":"Akazawa, Chihiro, Hitoshi Ohishi, Yoshiaki Nakajima, Naoyuki Okamoto, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Expression of MRNAs of L-AP4-Sensitive Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” <i>Neuroscience Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">https://doi.org/10.1016/0304-3940(94)90602-5</a>.","ieee":"C. Akazawa <i>et al.</i>, “Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina,” <i>Neuroscience Letters</i>, vol. 171, no. 1–2. Elsevier, pp. 52–54, 1994.","ista":"Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno N. 1994. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171(1–2), 52–54.","short":"C. Akazawa, H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi, N. Mizuno, Neuroscience Letters 171 (1994) 52–54.","mla":"Akazawa, Chihiro, et al. “Expression of MRNAs of L-AP4-Sensitive Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” <i>Neuroscience Letters</i>, vol. 171, no. 1–2, Elsevier, 1994, pp. 52–54, doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">10.1016/0304-3940(94)90602-5</a>.","ama":"Akazawa C, Ohishi H, Nakajima Y, et al. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. <i>Neuroscience Letters</i>. 1994;171(1-2):52-54. doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90602-5\">10.1016/0304-3940(94)90602-5</a>"},"publication_identifier":{"issn":["0304-3940"]},"acknowledgement":"The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from the Ministry of Education, Science and Culture of Japan.","status":"public","issue":"1-2","external_id":{"pmid":["8084499"]},"article_type":"original","_id":"2551","year":"1994","volume":171,"page":"52 - 54","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","scopus_import":"1","quality_controlled":"1","date_published":"1994-04-25T00:00:00Z","author":[{"first_name":"Chihiro","last_name":"Akazawa","full_name":"Akazawa, Chihiro"},{"full_name":"Ohishi, Hitoshi","last_name":"Ohishi","first_name":"Hitoshi"},{"last_name":"Nakajima","first_name":"Yoshiaki","full_name":"Nakajima, Yoshiaki"},{"full_name":"Okamoto, Naoyuki","first_name":"Naoyuki","last_name":"Okamoto"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Nakanishi","first_name":"Shigetada","full_name":"Nakanishi, Shigetada"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"article_processing_charge":"No","doi":"10.1016/0304-3940(94)90602-5","date_updated":"2022-06-08T14:02:11Z","month":"04","language":[{"iso":"eng"}],"pmid":1,"day":"25","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394094906025?via%3Dihub"}],"intvolume":"       171","publication_status":"published"},{"quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","doi":"10.1016/0304-3940(94)90469-3","date_updated":"2022-06-08T14:37:30Z","author":[{"full_name":"Ogawa Meguro, Reiko","last_name":"Ogawa Meguro","first_name":"Reiko"},{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Itoh, Kazuo","first_name":"Kazuo","last_name":"Itoh"},{"full_name":"Konishi, Akira","last_name":"Konishi","first_name":"Akira"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"date_published":"1994-01-31T00:00:00Z","publication_status":"published","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0304394094904693?via%3Dihub"}],"intvolume":"       166","month":"01","language":[{"iso":"eng"}],"day":"31","pmid":1,"publist_id":"4347","date_created":"2018-12-11T11:58:21Z","oa_version":"None","publisher":"Elsevier","publication":"Neuroscience Letters","title":"Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat","extern":"1","abstract":[{"text":"The superficial layers of the superior colliculus (SC) have been known to contain many axons showing substance P-like immunoreactivity (SP-LI). We, therefore, immunohistochemically examined the distribution of SP receptor (SPR) in the superficial layers of the SC in the rat by using a specific antibody against SPR. The majority of SC neurons with SPR-LI were distributed in the zonal and the superficial gray layers, the rest of them were in the optic layer. Electron microscopy revealed that SPR-immunoreaction products in SC neurons were distributed not only in postsynaptic sites, but also in non-synaptic regions of perikaryal and dendritic profiles.","lang":"eng"}],"year":"1994","_id":"2552","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":166,"page":"135 - 138","publication_identifier":{"issn":["0304-3940"]},"citation":{"short":"R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, N. Mizuno, Neuroscience Letters 166 (1994) 135–138.","mla":"Ogawa Meguro, Reiko, et al. “Immunohistochemical Localization of Substance P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>, vol. 166, no. 2, Elsevier, 1994, pp. 135–38, doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">10.1016/0304-3940(94)90469-3</a>.","ista":"Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. 1994. Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. Neuroscience Letters. 166(2), 135–138.","ama":"Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. <i>Neuroscience Letters</i>. 1994;166(2):135-138. doi:<a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">10.1016/0304-3940(94)90469-3</a>","apa":"Ogawa Meguro, R., Shigemoto, R., Itoh, K., Konishi, A., &#38; Mizuno, N. (1994). Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">https://doi.org/10.1016/0304-3940(94)90469-3</a>","ieee":"R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, and N. Mizuno, “Immunohistochemical localization of substance P receptor in the superior colliculus. A light and electron microscope study in the rat,” <i>Neuroscience Letters</i>, vol. 166, no. 2. Elsevier, pp. 135–138, 1994.","chicago":"Ogawa Meguro, Reiko, Ryuichi Shigemoto, Kazuo Itoh, Akira Konishi, and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in the Rat.” <i>Neuroscience Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0304-3940(94)90469-3\">https://doi.org/10.1016/0304-3940(94)90469-3</a>."},"issue":"2","article_type":"original","external_id":{"pmid":["8177489"]},"acknowledgement":"The authors are grateful for photographic help of Mr. Akira Uesugi.","status":"public"},{"_id":"2553","year":"1994","page":"F823 - F828","volume":266,"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ieee":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya, “Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney,” <i>American Journal of Physiology</i>, vol. 266, no. 5. American Physiological Society, pp. F823–F828, 1994.","chicago":"Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi, Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>. American Physiological Society, 1994. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>.","apa":"Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., &#38; Narumiya, S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. American Physiological Society. <a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">https://doi.org/10.1152/ajprenal.1994.266.5.F823</a>","ama":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. <i>American Journal of Physiology</i>. 1994;266(5):F823-F828. doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>","mla":"Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three Subtypes of Prostaglandin E Receptor in Kidney.” <i>American Journal of Physiology</i>, vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:<a href=\"https://doi.org/10.1152/ajprenal.1994.266.5.F823\">10.1152/ajprenal.1994.266.5.F823</a>.","ista":"Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. American Journal of Physiology. 266(5), F823–F828.","short":"Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya, American Journal of Physiology 266 (1994) F823–F828."},"publication_identifier":{"issn":["0363-6127"]},"status":"public","acknowledgement":"We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This work was supported in part by Scientific Research Grants-inAid 05404020, 04255103, 05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.","article_type":"original","external_id":{"pmid":["8203567"]},"issue":"5","oa_version":"None","date_created":"2018-12-11T11:58:21Z","publist_id":"4345","title":"Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney","publication":"American Journal of Physiology","publisher":"American Physiological Society","abstract":[{"lang":"eng","text":"Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1 subtype, which is coupled to Ca2+ mobilization, was specifically localized to the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype, which is linked to stimulation of adenylate cyclase, was localized to the glomeruli. The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase, was located densely in the tubules in the outer medulla and in the distal tubules in the cortex. These results exhibit distinct cellular localization of three subtypes of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions via these subtypes expressed in different segments of the nephron."}],"extern":"1","main_file_link":[{"url":"https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823"}],"intvolume":"       266","publication_status":"published","language":[{"iso":"eng"}],"month":"05","pmid":1,"day":"01","scopus_import":"1","quality_controlled":"1","author":[{"last_name":"Sugimoto","first_name":"Yukihiko","full_name":"Sugimoto, Yukihiko"},{"full_name":"Namba, Tsunehisa","last_name":"Namba","first_name":"Tsunehisa"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"full_name":"Negishi, Manabu","last_name":"Negishi","first_name":"Manabu"},{"last_name":"Ichikawa","first_name":"Atsushi","full_name":"Ichikawa, Atsushi"},{"full_name":"Narumiya, Shuh","first_name":"Shuh","last_name":"Narumiya"}],"date_published":"1994-05-01T00:00:00Z","doi":"10.1152/ajprenal.1994.266.5.F823","date_updated":"2022-06-07T15:03:51Z","article_processing_charge":"No"},{"date_updated":"2022-06-07T14:28:33Z","doi":"10.1016/0092-8674(94)90151-1","article_processing_charge":"No","author":[{"first_name":"Akinori","last_name":"Nomura","full_name":"Nomura, Akinori"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Nakamura, Yasuhisa","last_name":"Nakamura","first_name":"Yasuhisa"},{"full_name":"Okamoto, Naoyuki","last_name":"Okamoto","first_name":"Naoyuki"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"date_published":"1994-05-06T00:00:00Z","quality_controlled":"1","scopus_import":"1","day":"06","pmid":1,"language":[{"iso":"eng"}],"month":"05","publication_status":"published","intvolume":"        77","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0092867494901511?via%3Dihub"}],"extern":"1","abstract":[{"lang":"eng","text":"The retinal bipolar cell receiving glutamate transmission from photoreceptors mediates a key process in segregating visual signals into ON center and OFF center pathways. This transmission involves a G protein- coupled metabotropic glutamate receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic site of the rat rod bipolar cell. This specialization is developmentally regulated: mGluR6 is initially distributed in both the soma and dendrites and is finally concentrated on the postsynaptic site. The mGluR6 localization is reversed when photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is thus presented indicating specialized, developmentally regulated receptor distribution in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar cell synaptic transmission."}],"publisher":"Cell Press","title":"Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells","publication":"Cell","publist_id":"4344","oa_version":"None","date_created":"2018-12-11T11:58:21Z","external_id":{"pmid":["8181056"]},"article_type":"original","issue":"3","status":"public","acknowledgement":"We thank M. Tachibana for technical advice concerning dissociated bipolar cell preparation, Y. Honda for advice \r\nconcerning RCS rat experiments, and A. Uesugi for photographic assistance. This work is partly supported by research grants from the Ministry of Education, Science, and Culture of Japan and from the Ministry of Health and Welfare of\r\nJapan. ","publication_identifier":{"issn":["0092-8674"]},"citation":{"apa":"Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., &#38; Nakanishi, S. (1994). Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">https://doi.org/10.1016/0092-8674(94)90151-1</a>","ieee":"A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi, “Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells,” <i>Cell</i>, vol. 77, no. 3. Cell Press, pp. 361–369, 1994.","chicago":"Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto, Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>. Cell Press, 1994. <a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">https://doi.org/10.1016/0092-8674(94)90151-1</a>.","mla":"Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” <i>Cell</i>, vol. 77, no. 3, Cell Press, 1994, pp. 361–69, doi:<a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">10.1016/0092-8674(94)90151-1</a>.","short":"A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi, Cell 77 (1994) 361–369.","ista":"Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 77(3), 361–369.","ama":"Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. <i>Cell</i>. 1994;77(3):361-369. doi:<a href=\"https://doi.org/10.1016/0092-8674(94)90151-1\">10.1016/0092-8674(94)90151-1</a>"},"type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"361 - 369","volume":77,"year":"1994","_id":"2554"},{"publication_identifier":{"issn":["0896-6273"]},"citation":{"ama":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. <i>Neuron</i>. 1994;12(6):1245-1255. doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">10.1016/0896-6273(94)90441-3</a>","mla":"Shigemoto, Ryuichi, et al. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” <i>Neuron</i>, vol. 12, no. 6, Elsevier, 1994, pp. 1245–55, doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">10.1016/0896-6273(94)90441-3</a>.","ista":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. 1994. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. 12(6), 1245–1255.","short":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, T. Hirano, Neuron 12 (1994) 1245–1255.","chicago":"Shigemoto, Ryuichi, Takaaki Abe, Sakashi Nomura, Shigetada Nakanishi, and Tomoo Hirano. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” <i>Neuron</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">https://doi.org/10.1016/0896-6273(94)90441-3</a>.","ieee":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, and T. Hirano, “Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells,” <i>Neuron</i>, vol. 12, no. 6. Elsevier, pp. 1245–1255, 1994.","apa":"Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S., &#38; Hirano, T. (1994). Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(94)90441-3\">https://doi.org/10.1016/0896-6273(94)90441-3</a>"},"issue":"6","external_id":{"pmid":["7912091 "]},"article_type":"original","status":"public","acknowledgement":"Correspondence should be addressed to R. S. The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from Senri Life Science Foundation, the Brain Science Foundation, the Narishige Foundation, and the Ministry of Education, Science, and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","year":"1994","_id":"2555","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","volume":12,"page":"1245 - 1255","extern":"1","abstract":[{"lang":"eng","text":"Antibodies were raised against two distinct extracellular sequences of the rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins. Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we examined the role of mGluR1 in the induction of long-term depression in cultured Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically applied glutamate was persistently depressed by depolarization of the Purkinje cells in conjunction with the glutamate application. The mGluR1 antibodies completely blocked the depression of glutamate-induced current. The results indicate that activation of mGluR1 is necessary for the induction of cerebellar long-term depression and that these mGluR1 antibodies can be used as selective antagonists."}],"publist_id":"4343","date_created":"2018-12-11T11:58:22Z","oa_version":"None","publisher":"Elsevier","publication":"Neuron","title":"Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells","month":"06","language":[{"iso":"eng"}],"day":"01","pmid":1,"publication_status":"published","intvolume":"        12","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904413?via%3Dihub"}],"quality_controlled":"1","scopus_import":"1","article_processing_charge":"No","date_updated":"2022-06-07T13:39:09Z","doi":"10.1016/0896-6273(94)90441-3","author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi"},{"full_name":"Abe, Takaaki","first_name":"Takaaki","last_name":"Abe"},{"full_name":"Nomura, Sakashi","last_name":"Nomura","first_name":"Sakashi"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"},{"last_name":"Hirano","first_name":"Tomoo","full_name":"Hirano, Tomoo"}],"date_published":"1994-06-01T00:00:00Z"},{"publist_id":"4342","oa_version":"None","date_created":"2018-12-11T11:58:22Z","publisher":"Elsevier","title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex","publication":"Neuron","extern":"1","abstract":[{"text":"The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3 was immunohistochemically examined in the rat cerebellar cortex at both light and electron microscope levels. An antibody was raised against a fusion protein containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. The results suggest that transmitter glutamate may exert control influences upon Golgi cells not only through dendritic mGluR2/3, but also through axonal mGluR2/3.","lang":"eng"}],"year":"1994","_id":"2557","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","page":"55 - 66","volume":13,"publication_identifier":{"issn":["0896-6273"]},"citation":{"ama":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. <i>Neuron</i>. 1994;13(1):55-66. doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">10.1016/0896-6273(94)90459-6</a>","mla":"Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” <i>Neuron</i>, vol. 13, no. 1, Elsevier, 1994, pp. 55–66, doi:<a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">10.1016/0896-6273(94)90459-6</a>.","short":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, N. Mizuno, Neuron 13 (1994) 55–66.","ista":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.","chicago":"Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” <i>Neuron</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">https://doi.org/10.1016/0896-6273(94)90459-6</a>.","ieee":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex,” <i>Neuron</i>, vol. 13, no. 1. Elsevier, pp. 55–66, 1994.","apa":"Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., &#38; Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/0896-6273(94)90459-6\">https://doi.org/10.1016/0896-6273(94)90459-6</a>"},"external_id":{"pmid":["8043281"]},"article_type":"original","issue":"1","status":"public","acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic help. This work has been supported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part\r\nby the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","quality_controlled":"1","scopus_import":"1","doi":"10.1016/0896-6273(94)90459-6","date_updated":"2022-06-07T13:21:58Z","article_processing_charge":"No","author":[{"last_name":"Ohishi","first_name":"Hitoshi","full_name":"Ohishi, Hitoshi"},{"first_name":"Reiko","last_name":"Ogawa Meguro","full_name":"Ogawa Meguro, Reiko"},{"orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"},{"first_name":"Takeshi","last_name":"Kaneko","full_name":"Kaneko, Takeshi"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"date_published":"1994-07-01T00:00:00Z","publication_status":"published","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904596?via%3Dihub"}],"intvolume":"        13","language":[{"iso":"eng"}],"month":"07","day":"01","pmid":1}]