[{"article_type":"original","publist_id":"1904","year":"1996","oa_version":"None","external_id":{"pmid":["9007258"]},"scopus_import":"1","date_updated":"2022-08-04T14:20:50Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0950-1991"]},"date_published":"1996-12-01T00:00:00Z","_id":"4214","abstract":[{"text":"Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion, Two embryonic structures accomplish this behavior: the central nervous system (CNS) and skeletal muscles. To identify genes that are functionally involved in mediating and controlling different patterns of embryonic and larval motility, we included a simple touch response test in our zebrafish large-scale genetic screen, In total we identified 166 mutants with specific defects in embryonic motility. These mutants fall into 14 phenotypically distinct groups comprising at least 48 genes, Here we describe the various phenotypic groups including mutants with no or reduced motility, mechanosensory defective mutants, 'spastic' mutants, circling mutants and motor circuit defective mutants, In 63 mutants, defining 18 genes, striation of semitic muscles is reduced, Phenotypic analysis provides evidence that these 18 genes have distinct and consecutive functions during semitic muscle development. The genes sloth (slo) and frozen (fro) already act during myoblast differentiation, while 13 genes appear to function later, in the formation of myofibers and the organization of sarcomeres, Mutations in four other genes result in muscle-specific degeneration, 103 mutations, defining at least 30 genes, cause no obvious defects in muscle formation and may instead affect neuronal development. Analysis of the behavioral defects suggests that these genes participate in the diverse locomotion patterns observed, such as touch response, rhythmic tail movements, equilibrium control, or that they simply confer general motility to the animal, In some of these mutants specific defects in the developing nervous system are detected, Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes.","lang":"eng"}],"article_processing_charge":"No","volume":123,"publication_status":"published","day":"01","author":[{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"first_name":"Fredericus","full_name":"Van Eeden, Fredericus","last_name":"Van Eeden"},{"first_name":"Ursula","full_name":"Schach, Ursula","last_name":"Schach"},{"first_name":"Torsten","full_name":"Trowe, Torsten","last_name":"Trowe"},{"last_name":"Brand","full_name":"Brand, Michael","first_name":"Michael"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"last_name":"Haffter","full_name":"Haffter, Pascal","first_name":"Pascal"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"last_name":"Kelsh","full_name":"Kelsh, Robert","first_name":"Robert"},{"last_name":"Mullins","full_name":"Mullins, Mary","first_name":"Mary"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"type":"journal_article","citation":{"mla":"Granato, Michael, et al. “Genes Controlling and Mediating Locomotion Behavior of the Zebrafish Embryo and Larva.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 399–413, doi:<a href=\"https://doi.org/10.1242/dev.123.1.399\">10.1242/dev.123.1.399</a>.","ieee":"M. Granato <i>et al.</i>, “Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva,” <i>Development</i>, vol. 123. Company of Biologists, pp. 399–413, 1996.","ista":"Granato M, Van Eeden F, Schach U, Trowe T, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development. 123, 399–413.","chicago":"Granato, Michael, Fredericus Van Eeden, Ursula Schach, Torsten Trowe, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Genes Controlling and Mediating Locomotion Behavior of the Zebrafish Embryo and Larva.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.399\">https://doi.org/10.1242/dev.123.1.399</a>.","apa":"Granato, M., Van Eeden, F., Schach, U., Trowe, T., Brand, M., Furutani Seiki, M., … Nüsslein Volhard, C. (1996). Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.399\">https://doi.org/10.1242/dev.123.1.399</a>","ama":"Granato M, Van Eeden F, Schach U, et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. <i>Development</i>. 1996;123:399-413. doi:<a href=\"https://doi.org/10.1242/dev.123.1.399\">10.1242/dev.123.1.399</a>","short":"M. Granato, F. Van Eeden, U. Schach, T. Trowe, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 399–413."},"title":"Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva","language":[{"iso":"eng"}],"doi":"10.1242/dev.123.1.399","pmid":1,"acknowledgement":"We would like to thank C. Kimmel, J. Eisen and M. Westerfield for providing the nic and fub mutant strains used for complementation and for the znp1 antibody. In addition we thank Tanja Whitfield and Suresh Jesuthesan for critical reading of the manuscript. This work was supported by a DFG postdoctoral fellowship Gr 1370/1-1 to M.G.","month":"12","extern":"1","date_created":"2018-12-11T12:07:38Z","page":"399 - 413","publication":"Development","quality_controlled":"1","status":"public","intvolume":"       123","publisher":"Company of Biologists"},{"quality_controlled":"1","publication":"Development","status":"public","intvolume":"       123","publisher":"Company of Biologists","extern":"1","month":"12","date_created":"2018-12-11T12:07:38Z","page":"293 - 302","language":[{"iso":"eng"}],"doi":"10.1242/dev.123.1.293","acknowledgement":"We thank Chris Simpson and Colleen Boggs for excellent technical help. We thank Mark C. Fishman for the advice and providing fish for complementation; Bernadette Fouquet, Kerri S. Warren and Brant M. Weinstein for critically reading the manuscript. JNC is supported in part by NIH grant RO1-HL49579 to Mark C. Fishman.","pmid":1,"day":"01","type":"journal_article","author":[{"full_name":"Chen, Jaunian","first_name":"Jaunian","last_name":"Chen"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"first_name":"Elisabeth","full_name":"Vogelsang, Elisabeth","last_name":"Vogelsang"},{"last_name":"Brand","first_name":"Michael","full_name":"Brand, Michael"},{"first_name":"Fredericus","full_name":"Van Eeden, Fredericus","last_name":"Van Eeden"},{"last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto","first_name":"Makoto"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Hammerschmidt","full_name":"Hammerschmidt, Matthias","first_name":"Matthias"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"},{"full_name":"Jiang, Yunjin","first_name":"Yunjin","last_name":"Jiang"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"last_name":"Kelsh","first_name":"Robert","full_name":"Kelsh, Robert"},{"first_name":"Mary","full_name":"Mullins, Mary","last_name":"Mullins"},{"last_name":"Nüsslein Volhard","first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane"}],"citation":{"mla":"Chen, Jaunian, et al. “Mutations Affecting the Cardiovascular System and Other Internal Organs in Zebrafish.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 293–302, doi:<a href=\"https://doi.org/10.1242/dev.123.1.293\">10.1242/dev.123.1.293</a>.","chicago":"Chen, Jaunian, Pascal Haffter, Jörg Odenthal, Elisabeth Vogelsang, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting the Cardiovascular System and Other Internal Organs in Zebrafish.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.293\">https://doi.org/10.1242/dev.123.1.293</a>.","ieee":"J. Chen <i>et al.</i>, “Mutations affecting the cardiovascular system and other internal organs in zebrafish,” <i>Development</i>, vol. 123. Company of Biologists, pp. 293–302, 1996.","ista":"Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Nüsslein Volhard C. 1996. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development. 123, 293–302.","ama":"Chen J, Haffter P, Odenthal J, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. <i>Development</i>. 1996;123:293-302. doi:<a href=\"https://doi.org/10.1242/dev.123.1.293\">10.1242/dev.123.1.293</a>","apa":"Chen, J., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Van Eeden, F., … Nüsslein Volhard, C. (1996). Mutations affecting the cardiovascular system and other internal organs in zebrafish. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.293\">https://doi.org/10.1242/dev.123.1.293</a>","short":"J. Chen, P. Haffter, J. Odenthal, E. Vogelsang, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 293–302."},"title":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","volume":123,"publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/293/39344/Mutations-affecting-the-cardiovascular-system-and"}],"_id":"4215","abstract":[{"lang":"eng","text":"In a screen for early developmental mutants of the zebrafish, we have identified mutations specifically affecting the internal organs, We identified 53 mutations affecting the cardiovascular system, Nine of them affect specific landmarks of heart morphogenesis. Mutations in four genes cause a failure in the fusion of the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no heart venticle is visible and the atrium is directly fused to the outflow tract. In the overlooped mutant, the relative position of the two heart chambers is distorted, The heart is enormously enlarged in the santa mutant, In two mutants, scotch tape and superglue, the cardiac jelly between the two layers of the heart is significantly reduced, We also identified a number of mutations affecting the function of the heart, The mutations affecting heart function can be subdivided into two groups, one affecting heart contraction and another affecting the rhythm of the heart beat. Among the contractility group of mutants are 5 with no heart beat at all and 15 with a reduced heart beat of one or both chambers, 6 mutations are in the rhythmicity group and specifically affect the beating pattern of the heart, Mutations in two genes, bypass and kurzschluss, cause specific defects in the circulatory system, In addition to the heart mutants, we identified 23 mutations affecting the integrity of the liver, the intestine or the kidney, In this report, we demonstrate that it is feasible to screen for genes specific for the patterning or function of certain internal organs in the zebrafish, The mutations presented here could serve as an entrypoint to the establishment of a genetic hierarchy underlying organogenesis."}],"date_published":"1996-12-01T00:00:00Z","article_processing_charge":"No","date_updated":"2022-08-04T13:11:56Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["9007249"]},"scopus_import":"1","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1902","article_type":"original","year":"1996","oa_version":"Published Version"},{"doi":"10.1242/dev.123.1.129 ","language":[{"iso":"eng"}],"acknowledgement":"We would like to thank our colleagues in the zebrafish community for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript, his colleagues at the institute for numerous discussions, Inge Zimmermann for patient sectioning, and Silke Hein for help during the final\r\nstages of this work. M. B. was supported by a Helmholtz stipend of the BMFT.","pmid":1,"type":"journal_article","author":[{"first_name":"Michael","full_name":"Brand, Michael","last_name":"Brand"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"},{"full_name":"Warga, Rachel","first_name":"Rachel","last_name":"Warga"},{"last_name":"Pelegri","full_name":"Pelegri, Francisco","first_name":"Francisco"},{"last_name":"Karlstrom","full_name":"Karlstrom, Rolf","first_name":"Rolf"},{"last_name":"Beuchle","full_name":"Beuchle, Dirk","first_name":"Dirk"},{"first_name":"Alexander","full_name":"Picker, Alexander","last_name":"Picker"},{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Haffter","full_name":"Haffter, Pascal","first_name":"Pascal"},{"first_name":"Matthias","full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"first_name":"Robert","full_name":"Kelsh, Robert","last_name":"Kelsh"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"first_name":"Jörg","full_name":"Odenthal, Jörg","last_name":"Odenthal"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"day":"01","title":"Mutations affecting development of the midline and general body shape during zebrafish embryogenesis","citation":{"chicago":"Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri, Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development of the Midline and General Body Shape during Zebrafish Embryogenesis.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.129 \">https://doi.org/10.1242/dev.123.1.129 </a>.","ieee":"M. Brand <i>et al.</i>, “Mutations affecting development of the midline and general body shape during zebrafish embryogenesis,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 129–142, 1996.","ista":"Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development. 123(1), 129–142.","mla":"Brand, Michael, et al. “Mutations Affecting Development of the Midline and General Body Shape during Zebrafish Embryogenesis.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 129–42, doi:<a href=\"https://doi.org/10.1242/dev.123.1.129 \">10.1242/dev.123.1.129 </a>.","short":"M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle, A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 129–142.","ama":"Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. <i>Development</i>. 1996;123(1):129-142. doi:<a href=\"https://doi.org/10.1242/dev.123.1.129 \">10.1242/dev.123.1.129 </a>","apa":"Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle, D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.129 \">https://doi.org/10.1242/dev.123.1.129 </a>"},"status":"public","intvolume":"       123","quality_controlled":"1","publication":"Development","publisher":"Company of Biologists","date_created":"2018-12-11T12:07:38Z","extern":"1","month":"12","page":"129 - 142","publication_identifier":{"issn":["0950-1991"]},"date_updated":"2022-08-04T12:55:13Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","scopus_import":"1","external_id":{"pmid":["9007235 "]},"oa_version":"Published Version","year":"1996","publist_id":"1900","article_type":"original","volume":123,"main_file_link":[{"url":"https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and","open_access":"1"}],"oa":1,"publication_status":"published","date_published":"1996-12-01T00:00:00Z","_id":"4216","abstract":[{"text":"Tissues of the dorsal midline of vertebrate embryos, such as notochord and floor plate, have been implicated in inductive interactions that pattern the neural tube and somites. In our screen for embryonic visible mutations in the zebrafish we found 113 mutations in more than 27 genes with altered body shape, often with additional defects in CNS development. We concentrated on a subgroup of mutations in ten genes (the midline-group) that cause defective development of the floor plate. By using floor plate markers, such as the signaling molecule sonic hedgehog, we show that the schmalspur (sur) gene is needed for early floor plate development, similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene. In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In the underlying mesendodermal tissue of the head, sur is needed only for development of the posterior prechordal plate, whereas oep and eye are required for both anterior and posterior prechordal plate development. Our analysis of sur mutants suggests that defects within the posterior prechordal plate may cause aberrant development of ventral CNS structures in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour, schmalkars and monorail embryos; these mutants often show additional defects in tissues that are known to depend on signals from notochord and floor plate, For example, sur, con, and yot mutants show reduction of motor neurons; median deletions of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and dtr mutants often show no or abnormal formation of the optic chiasm. We also find fusions of the ventral neurocranium for all midline mutants tested, which may reveal a hitherto unrecognized function of the midline in influencing differentiation of neural crest cells at their destination. As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues.","lang":"eng"}],"issue":"1","article_processing_charge":"No"},{"_id":"4219","date_published":"1996-12-01T00:00:00Z","abstract":[{"text":"Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that the MHB region and the dorsal and ventral midbrain are absent or abnormal, but that the rostral hindbrain is unaffected with the exception of the cerebellum, Using markers that are expressed during its formation (eng, wnt1 and pax-b), we find that the MHB region is already misspecified in noi mutant embryos during late gastrulation. The tectum is initially present and later degenerates, The defect in ace mutant embryos is more restricted: MHB and cerebellum are absent, but a tectum is formed, Molecular organisation of the tectum and tegmentum is disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained, We propose that noi and ace are required for development of the MHB region and of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB region, Presence of pax-b RNA, and absence of pax-b protein, together with the observation of genetic linkage and the occurrence of a point mutation, show that noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue of the Drosophila gene paired, which is involved in a pathway of cellular interactions at the posterior compartment boundary in Drosophila, Our results confirm and extend a previous report, and show that at least one member of this conserved signalling pathway is required for formation of the boundary between midbrain and hindbrain in the zebrafish.","lang":"eng"}],"issue":"1","article_processing_charge":"No","volume":123,"oa":1,"main_file_link":[{"url":"https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the","open_access":"1"}],"publication_status":"published","year":"1996","oa_version":"Published Version","publist_id":"1899","article_type":"original","publication_identifier":{"issn":["0950-1991"]},"date_updated":"2022-08-04T11:45:04Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["9007239 "]},"scopus_import":"1","date_created":"2018-12-11T12:07:40Z","extern":"1","month":"12","page":"179 - 190","status":"public","intvolume":"       123","quality_controlled":"1","publication":"Development","publisher":"Company of Biologists","author":[{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg"},{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"full_name":"Beuchle, Dirk","first_name":"Dirk","last_name":"Beuchle"},{"full_name":"Lun, Klaus","first_name":"Klaus","last_name":"Lun"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"first_name":"Michael","full_name":"Granato, Michael","last_name":"Granato"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"first_name":"Donald","full_name":"Kane, Donald","last_name":"Kane"},{"first_name":"Robert","full_name":"Kelsh, Robert","last_name":"Kelsh"},{"first_name":"Mary","full_name":"Mullins, Mary","last_name":"Mullins"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"type":"journal_article","day":"01","title":"Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain","citation":{"ama":"Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. <i>Development</i>. 1996;123(1):179-190. doi:<a href=\"https://doi.org/10.1242/dev.123.1.179 \">10.1242/dev.123.1.179 </a>","apa":"Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.179 \">https://doi.org/10.1242/dev.123.1.179 </a>","short":"M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.","mla":"Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 179–90, doi:<a href=\"https://doi.org/10.1242/dev.123.1.179 \">10.1242/dev.123.1.179 </a>.","chicago":"Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.179 \">https://doi.org/10.1242/dev.123.1.179 </a>.","ista":"Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.","ieee":"M. Brand <i>et al.</i>, “Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 179–190, 1996."},"doi":"10.1242/dev.123.1.179 ","language":[{"iso":"eng"}],"acknowledgement":"We would like to thank our colleagues in the zebrafish community for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder, Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B would like to thank his colleagues for numerous discussions, and Francisco Pelegri, Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression, and especially to Corinne Houart, for her lovely in situ protocol and many discussions. Silke Hein helped greatly in final stages of this work. M.B. was supported by a Helmholtz stipend of the BMFT.","pmid":1},{"publist_id":"1896","article_type":"original","oa_version":"Published Version","year":"1996","date_updated":"2022-08-04T10:01:17Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["9007245 "]},"scopus_import":"1","publication_identifier":{"issn":["0950-1991"]},"issue":"1","article_processing_charge":"No","_id":"4220","date_published":"1996-12-01T00:00:00Z","abstract":[{"lang":"eng","text":"In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during embryogenesis. At larval stages the caudal fin fold is replaced by four different fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins are formed, We have identified a total of 118 mutations affecting larval fin formation, Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly normal complement of adult fins, Mutations in nine genes result in an increased or reduced size of the pectoral fins, Interestingly, in mutants of one of these genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations in five other genes affect adult fin but not larval fin development, Two mutants, longfin (lof) and another longfin (alf) have generally longer fins. Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins, Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported."}],"publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish"}],"volume":123,"citation":{"short":"F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262.","apa":"Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter, P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.255 \">https://doi.org/10.1242/dev.123.1.255 </a>","ama":"Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):255-262. doi:<a href=\"https://doi.org/10.1242/dev.123.1.255 \">10.1242/dev.123.1.255 </a>","ieee":"F. Van Eeden <i>et al.</i>, “Genetic analysis of fin formation in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 255–262, 1996.","ista":"Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish, Danio rerio. Development. 123(1), 255–262.","chicago":"Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis of Fin Formation in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.255 \">https://doi.org/10.1242/dev.123.1.255 </a>.","mla":"Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 255–62, doi:<a href=\"https://doi.org/10.1242/dev.123.1.255 \">10.1242/dev.123.1.255 </a>."},"title":"Genetic analysis of fin formation in the zebrafish, Danio rerio","day":"01","type":"journal_article","author":[{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"first_name":"Michael","full_name":"Granato, Michael","last_name":"Granato"},{"first_name":"Ursula","full_name":"Schach, Ursula","last_name":"Schach"},{"last_name":"Brand","full_name":"Brand, Michael","first_name":"Michael"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"last_name":"Haffter","full_name":"Haffter, Pascal","first_name":"Pascal"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jiang","full_name":"Jiang, Yunjin","first_name":"Yunjin"},{"last_name":"Kane","full_name":"Kane, Donald","first_name":"Donald"},{"first_name":"Robert","full_name":"Kelsh, Robert","last_name":"Kelsh"},{"first_name":"Mary","full_name":"Mullins, Mary","last_name":"Mullins"},{"first_name":"Jörg","full_name":"Odenthal, Jörg","last_name":"Odenthal"},{"last_name":"Warga","full_name":"Warga, Rachel","first_name":"Rachel"},{"last_name":"Nüsslein Volhard","first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane"}],"pmid":1,"language":[{"iso":"eng"}],"doi":"10.1242/dev.123.1.255 ","page":"255 - 262","extern":"1","month":"12","date_created":"2018-12-11T12:07:40Z","publisher":"Company of Biologists","quality_controlled":"1","publication":"Development","status":"public","intvolume":"       123"},{"volume":123,"publication_status":"published","oa":1,"main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and"}],"abstract":[{"text":"Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of vertebrate embryos, Two groups of mutants with defects in this patterning process have been isolated in our screen for zygotic mutations affecting the embryonic development of the zebrafish (Danio rerio), In mutants of the first group, boundaries between individual somites are invisible early on, although the paraxial mesoderm is present, Later, irregular boundaries between somites are present, Mutations infused somites (fss) and beamter (bea) affect all somites, whereas mutations in deadly seven (des), after eight (aei) and white tail (wit) only affect the more posterior somites, Mutants of all genes but wit are homozygous viable and fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest that anteroposterior patterning within individual somites is abnormal, In the second group of mutants, formation of the horizontal myoseptum, which separates the dorsal and ventral part of the myotome, is reduced, Six genes have been defined in this group (you-type genes), yea-too mutants show the most severe phenotype; in these the adaxial cells, muscle pioneers and the primary motoneurons are affected, in addition to the horizontal myoseptum. The horizontal myoseptum is also missing in mutants that lack a notochord. The similarity of the somite phenotype in mutants lacking the notochord and in the you-type mutants suggests that the genes mutated in these two groups are involved in a signaling pathway from the notochord, important for patterning of the somites.","lang":"eng"}],"_id":"4222","date_published":"1996-12-01T00:00:00Z","article_processing_charge":"No","issue":"1","scopus_import":"1","external_id":{"pmid":["9007237 "]},"date_updated":"2022-08-04T09:29:56Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0950-1991"]},"article_type":"original","publist_id":"1895","year":"1996","oa_version":"Published Version","publication":"Development","quality_controlled":"1","status":"public","intvolume":"       123","publisher":"Company of Biologists","month":"12","extern":"1","date_created":"2018-12-11T12:07:41Z","page":"153 - 164","language":[{"iso":"eng"}],"doi":"10.1242/dev.123.1.153","pmid":1,"acknowledgement":"We would like to thank P. Ingham and T. Whitfield for valuable comments on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J. Eisen and R. BreMiller for the znp-1 antibody.","day":"01","type":"journal_article","author":[{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Schach","full_name":"Schach, Ursula","first_name":"Ursula"},{"first_name":"Michael","full_name":"Brand, Michael","last_name":"Brand"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"first_name":"Pascal","full_name":"Haffter, Pascal","last_name":"Haffter"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J"},{"first_name":"Yunjin","full_name":"Jiang, Yunjin","last_name":"Jiang"},{"first_name":"Donald","full_name":"Kane, Donald","last_name":"Kane"},{"first_name":"Robert","full_name":"Kelsh, Robert","last_name":"Kelsh"},{"last_name":"Mullins","first_name":"Mary","full_name":"Mullins, Mary"},{"last_name":"Odenthal","full_name":"Odenthal, Jörg","first_name":"Jörg"},{"first_name":"Rachel","full_name":"Warga, Rachel","last_name":"Warga"},{"first_name":"Miguel","full_name":"Allende, Miguel","last_name":"Allende"},{"first_name":"Eric","full_name":"Weinberg, Eric","last_name":"Weinberg"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"citation":{"mla":"Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 153–64, doi:<a href=\"https://doi.org/10.1242/dev.123.1.153\">10.1242/dev.123.1.153</a>.","ista":"Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.","ieee":"F. Van Eeden <i>et al.</i>, “Mutations affecting somite formation and patterning in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 153–164, 1996.","chicago":"Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting Somite Formation and Patterning in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.153\">https://doi.org/10.1242/dev.123.1.153</a>.","apa":"Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter, P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.153\">https://doi.org/10.1242/dev.123.1.153</a>","ama":"Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):153-164. doi:<a href=\"https://doi.org/10.1242/dev.123.1.153\">10.1242/dev.123.1.153</a>","short":"F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development 123 (1996) 153–164."},"title":"Mutations affecting somite formation and patterning in the zebrafish, Danio rerio"},{"month":"10","extern":"1","_id":"4292","date_published":"1996-10-22T00:00:00Z","date_created":"2018-12-11T12:08:05Z","abstract":[{"lang":"eng","text":"Ageing, or senescence, is a decline in state at later ages that is manifested through a reduction in survival and fecundity. Ageing means that reproductive prospects and hence the life history options (trade-offs) open to the organism decline. Evolutionary theories of ageing suggest that it evolves in response to the level of externally imposed mortality and insults to fertility, either as part of life history optimization or as a result of mutation pressure. Several recent empirical and theoretical studies have produced apparently anomalous results. Some have suggested that the rate of ageing can decline at later ages, others that demographic evidence for ageing can appear in parallel with an improvement in state. All of these studies used measures of ageing that would not be expected to give an accurate reflection of changes in the state of the organism with age. We propose that Fisher's `reproductive value' is a natural measure of state at each age, which includes prospects for both survival and reproduction. If this measure is used, the apparently anomalous findings are not at variance with evolutionary theories of ageing."}],"page":"1365 - 1371","article_processing_charge":"No","issue":"1375","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","quality_controlled":"1","status":"public","intvolume":"       263","volume":263,"publication_status":"published","publisher":"Royal Society of London","main_file_link":[{"url":"https://royalsocietypublishing.org/doi/abs/10.1098/rspb.1996.0200"}],"day":"22","publist_id":"1786","author":[{"last_name":"Partridge","full_name":"Partridge, Linda","first_name":"Linda"},{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240"}],"type":"journal_article","oa_version":"None","year":"1996","citation":{"short":"L. Partridge, N.H. Barton, Proceedings of the Royal Society of London Series B Biological Sciences 263 (1996) 1365–1371.","apa":"Partridge, L., &#38; Barton, N. H. (1996). On measuring the rate of ageing. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rspb.1996.0200\">https://doi.org/10.1098/rspb.1996.0200</a>","ama":"Partridge L, Barton NH. On measuring the rate of ageing. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 1996;263(1375):1365-1371. doi:<a href=\"https://doi.org/10.1098/rspb.1996.0200\">10.1098/rspb.1996.0200</a>","ista":"Partridge L, Barton NH. 1996. On measuring the rate of ageing. Proceedings of the Royal Society of London Series B Biological Sciences. 263(1375), 1365–1371.","ieee":"L. Partridge and N. H. Barton, “On measuring the rate of ageing,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 263, no. 1375. Royal Society of London, pp. 1365–1371, 1996.","chicago":"Partridge, Linda, and Nicholas H Barton. “On Measuring the Rate of Ageing.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society of London, 1996. <a href=\"https://doi.org/10.1098/rspb.1996.0200\">https://doi.org/10.1098/rspb.1996.0200</a>.","mla":"Partridge, Linda, and Nicholas H. Barton. “On Measuring the Rate of Ageing.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 263, no. 1375, Royal Society of London, 1996, pp. 1365–71, doi:<a href=\"https://doi.org/10.1098/rspb.1996.0200\">10.1098/rspb.1996.0200</a>."},"title":"On measuring the rate of ageing","language":[{"iso":"eng"}],"date_updated":"2022-07-04T12:59:56Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0950-1193"]},"doi":"10.1098/rspb.1996.0200"},{"citation":{"short":"N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University Press, 1996, pp. 23–56.","apa":"Barton, N. H., &#38; Wilson, I. (1996). Genealogies and geography. In <i>New uses for new phylogenies</i> (pp. 23–56). Oxford University Press. <a href=\"https://doi.org/10.1098/rstb.1995.0090\">https://doi.org/10.1098/rstb.1995.0090</a>","ama":"Barton NH, Wilson I. Genealogies and geography. In: <i>New Uses for New Phylogenies</i>. Oxford University Press; 1996:23-56. doi:<a href=\"https://doi.org/10.1098/rstb.1995.0090\">10.1098/rstb.1995.0090</a>","ieee":"N. H. Barton and I. Wilson, “Genealogies and geography,” in <i>New uses for new phylogenies</i>, Oxford University Press, 1996, pp. 23–56.","ista":"Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new phylogenies. , 23–56.","chicago":"Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In <i>New Uses for New Phylogenies</i>, 23–56. Oxford University Press, 1996. <a href=\"https://doi.org/10.1098/rstb.1995.0090\">https://doi.org/10.1098/rstb.1995.0090</a>.","mla":"Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” <i>New Uses for New Phylogenies</i>, Oxford University Press, 1996, pp. 23–56, doi:<a href=\"https://doi.org/10.1098/rstb.1995.0090\">10.1098/rstb.1995.0090</a>."},"title":"Genealogies and geography","publist_id":"1783","day":"01","oa_version":"None","year":"1996","type":"book_chapter","author":[{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H"},{"first_name":"Ian","full_name":"Wilson, Ian","last_name":"Wilson"}],"pmid":1,"date_updated":"2022-08-04T08:59:18Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","language":[{"iso":"eng"}],"external_id":{"pmid":["8748019"]},"doi":"10.1098/rstb.1995.0090","publication_identifier":{"isbn":["978-0198549840"]},"page":"23 - 56","article_processing_charge":"No","extern":"1","month":"01","date_created":"2018-12-11T12:08:05Z","_id":"4294","date_published":"1996-01-01T00:00:00Z","abstract":[{"lang":"eng","text":"Any sample of genes traces back to a single common ancestor. Each gene also has other properties: its sequence, its geographic location and the phenotype and fitness of the organism that carries it. With sexual reproduction, different genes have different genealogies, which gives us much more information, but also greatly complicates population genetic analysis. We review the close relation between the distribution of genealogies and the classic theory of identity by descent in spatially structured populations, and develop a simple diffusion approximation to the distribution of coalescence times in a homogeneous two-dimensional habitat. This shows that when neighbourhood size is large (as in most populations) only a small fraction of pairs of genes are closely related, and only this fraction gives information about current rates of gene flow. The increase of spatial dispersion with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy depends on the long-term history of the population; we discuss ways of inferring this history from the concordance between genealogies across loci."}],"publication_status":"published","publisher":"Oxford University Press","quality_controlled":"1","publication":"New uses for new phylogenies","status":"public"},{"publication_identifier":{"issn":["0960-9822"]},"date_updated":"2022-07-07T09:28:28Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["8939554"]},"scopus_import":"1","oa_version":"Published Version","year":"1996","publist_id":"1781","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub","open_access":"1"}],"oa":1,"publication_status":"published","volume":6,"article_processing_charge":"No","abstract":[{"text":"Genetic studies are beginning to provide insights into the evolutionary processes that reduce the fitness of hybrids between recently diverged species. However, the deleterious gene interactions responsible for this fitness reduction are still poorly understood.","lang":"eng"}],"_id":"4295","date_published":"1996-10-01T00:00:00Z","acknowledgement":"Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael Turelli for their comments on this note, and to the BBSRC and NERC for financial support.","pmid":1,"doi":"10.1016/S0960-9822(02)70707-0","language":[{"iso":"eng"}],"title":"Speciation: more than the sum of its parts","citation":{"short":"N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.","apa":"Barton, N. H. (1996). Speciation: more than the sum of its parts. In <i>Current Biology</i> (Vol. 6, pp. 1244–1246). Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">https://doi.org/10.1016/S0960-9822(02)70707-0</a>","ama":"Barton NH. Speciation: more than the sum of its parts. In: <i>Current Biology</i>. Vol 6. Cell Press; 1996:1244-1246. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">10.1016/S0960-9822(02)70707-0</a>","ieee":"N. H. Barton, “Speciation: more than the sum of its parts,” in <i>Current Biology</i>, vol. 6, Cell Press, 1996, pp. 1244–1246.","ista":"Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology. vol. 6, 1244–1246.","chicago":"Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In <i>Current Biology</i>, 6:1244–46. Cell Press, 1996. <a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">https://doi.org/10.1016/S0960-9822(02)70707-0</a>.","mla":"Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” <i>Current Biology</i>, vol. 6, Cell Press, 1996, pp. 1244–46, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">10.1016/S0960-9822(02)70707-0</a>."},"author":[{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H"}],"type":"book_chapter","day":"01","publisher":"Cell Press","status":"public","intvolume":"         6","quality_controlled":"1","publication":"Current Biology","page":"1244 - 1246","date_created":"2018-12-11T12:08:06Z","extern":"1","month":"10"},{"status":"public","publication_status":"published","publisher":"Cornell University","supervisor":[{"last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"}],"_id":"4419","abstract":[{"text":"A {\\em hybrid automaton\\/} consists of a finite automaton interacting with a dynamical system. Hybrid automata are used to model embedded controllers and other systems that consist of interacting discrete and continuous components. A hybrid automaton is {\\em rectangular\\/} if each of its continuous variables~x satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where a and~b are rational constants. Rectangular hybrid automata are particularly useful for the analysis of communication protocols in which local clocks have bounded drift, and for the conservative approximation of systems with more complex continuous behavior. We examine several verification problems on the class of rectangular hybrid automata, including reachability, temporal logic model checking, and controller synthesis. Both dense-time and discrete-time models are considered. We identify subclasses of rectangular hybrid automata for which these problems are decidable and give complexity analyses. An investigation of the structural properties of rectangular hybrid automata is undertaken. One method for proving the decidability of verification problems on infinite-state systems is to find finite quotient systems on which analysis can proceed. Three state-space equivalence relations with strong connections to temporal logic are bisimilarity, similarity, and language equivalence. We characterize the quotient spaces of rectangular hybrid automata with respect to these equivalence relations.","lang":"eng"}],"date_created":"2018-12-11T12:08:45Z","date_published":"1996-01-01T00:00:00Z","month":"01","extern":"1","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-07-06T15:11:24Z","language":[{"iso":"eng"}],"type":"dissertation","author":[{"full_name":"Kopke, Peter","first_name":"Peter","last_name":"Kopke"}],"year":"1996","oa_version":"None","publist_id":"312","day":"01","title":"The Theory of Rectangular Hybrid Automata","citation":{"mla":"Kopke, Peter. <i>The Theory of Rectangular Hybrid Automata</i>. Cornell University, 1996.","ista":"Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.","ieee":"P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University, 1996.","chicago":"Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University, 1996.","apa":"Kopke, P. (1996). <i>The Theory of Rectangular Hybrid Automata</i>. Cornell University.","ama":"Kopke P. The Theory of Rectangular Hybrid Automata. 1996.","short":"P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University, 1996."}},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-07-06T09:58:25Z","publication_identifier":{"isbn":["9783540611554"]},"publist_id":"302","year":"1996","oa_version":"None","editor":[{"first_name":"Rajeev","full_name":"Alur, Rajeev","last_name":"Alur"},{"last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A"},{"full_name":"Sontag, Eduardo","first_name":"Eduardo","last_name":"Sontag"}],"volume":1066,"publication_status":"published","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/BFb0020961"}],"date_published":"1996-01-01T00:00:00Z","_id":"4426","abstract":[{"lang":"eng","text":"We use linear hybrid automata to define linear approximations of the phase portraits of nonlinear hybrid systems. The approximating automata can be analyzed automatically using the symbolic model checker HyTech. We demonstrate the technique through the study of predator-prey systems, where we compute population bounds for both species. We also identify a class of nonlinear hybrid automata for which linear phase-portrait approximations can be generated automatically."}],"article_processing_charge":"No","language":[{"iso":"eng"}],"doi":"10.1007/BFb0020961","acknowledgement":"This research was supported in part by the ONR YIP award N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by the NSF grants CCR-9200794 and CCR-9504469, by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.","day":"01","alternative_title":["LNCS"],"author":[{"first_name":"Thomas A","full_name":"Henzinger, Thomas A","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724"},{"first_name":"Howard","full_name":"Wong Toi, Howard","last_name":"Wong Toi"}],"type":"conference","citation":{"chicago":"Henzinger, Thomas A, and Howard Wong Toi. “Linear Phase-Portrait Approximations for Nonlinear Hybrid Systems.” In <i>Hybrid Systems III: Verification and Control</i>, edited by Rajeev Alur, Thomas A Henzinger, and Eduardo Sontag, 1066:377–88. Springer, 1996. <a href=\"https://doi.org/10.1007/BFb0020961\">https://doi.org/10.1007/BFb0020961</a>.","ista":"Henzinger TA, Wong Toi H. 1996. Linear phase-portrait approximations for nonlinear hybrid systems. Hybrid Systems III: Verification and Control. , LNCS, vol. 1066, 377–388.","ieee":"T. A. Henzinger and H. Wong Toi, “Linear phase-portrait approximations for nonlinear hybrid systems,” in <i>Hybrid Systems III: Verification and Control</i>, 1996, vol. 1066, pp. 377–388.","mla":"Henzinger, Thomas A., and Howard Wong Toi. “Linear Phase-Portrait Approximations for Nonlinear Hybrid Systems.” <i>Hybrid Systems III: Verification and Control</i>, edited by Rajeev Alur et al., vol. 1066, Springer, 1996, pp. 377–88, doi:<a href=\"https://doi.org/10.1007/BFb0020961\">10.1007/BFb0020961</a>.","short":"T.A. Henzinger, H. Wong Toi, in:, R. Alur, T.A. Henzinger, E. Sontag (Eds.), Hybrid Systems III: Verification and Control, Springer, 1996, pp. 377–388.","ama":"Henzinger TA, Wong Toi H. Linear phase-portrait approximations for nonlinear hybrid systems. In: Alur R, Henzinger TA, Sontag E, eds. <i>Hybrid Systems III: Verification and Control</i>. Vol 1066. Springer; 1996:377-388. doi:<a href=\"https://doi.org/10.1007/BFb0020961\">10.1007/BFb0020961</a>","apa":"Henzinger, T. A., &#38; Wong Toi, H. (1996). Linear phase-portrait approximations for nonlinear hybrid systems. In R. Alur, T. A. Henzinger, &#38; E. Sontag (Eds.), <i>Hybrid Systems III: Verification and Control</i> (Vol. 1066, pp. 377–388). Springer. <a href=\"https://doi.org/10.1007/BFb0020961\">https://doi.org/10.1007/BFb0020961</a>"},"title":"Linear phase-portrait approximations for nonlinear hybrid systems","quality_controlled":"1","publication":"Hybrid Systems III: Verification and Control","status":"public","intvolume":"      1066","publisher":"Springer","extern":"1","month":"01","date_created":"2018-12-11T12:08:47Z","page":"377 - 388"},{"doi":"10.1007/BFb0027241","language":[{"iso":"eng"}],"acknowledgement":"This research was supported in part by the ONR YIP award N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.","alternative_title":["LNCS"],"type":"book_chapter","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","first_name":"Thomas A","last_name":"Henzinger"},{"last_name":"Wong Toi","first_name":"Howard","full_name":"Wong Toi, Howard"}],"day":"01","title":"Using HyTech to synthesize control parameters for a steam boiler","citation":{"mla":"Henzinger, Thomas A., and Howard Wong Toi. “Using HyTech to Synthesize Control Parameters for a Steam Boiler.” <i>Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control</i>, vol. 1165, Springer, 1996, pp. 265–82, doi:<a href=\"https://doi.org/10.1007/BFb0027241\">10.1007/BFb0027241</a>.","chicago":"Henzinger, Thomas A, and Howard Wong Toi. “Using HyTech to Synthesize Control Parameters for a Steam Boiler.” In <i>Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control</i>, 1165:265–82. Springer, 1996. <a href=\"https://doi.org/10.1007/BFb0027241\">https://doi.org/10.1007/BFb0027241</a>.","ista":"Henzinger TA, Wong Toi H. 1996.Using HyTech to synthesize control parameters for a steam boiler. In: Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control. LNCS, vol. 1165, 265–282.","ieee":"T. A. Henzinger and H. Wong Toi, “Using HyTech to synthesize control parameters for a steam boiler,” in <i>Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control</i>, vol. 1165, Springer, 1996, pp. 265–282.","ama":"Henzinger TA, Wong Toi H. Using HyTech to synthesize control parameters for a steam boiler. In: <i>Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control</i>. Vol 1165. Springer; 1996:265-282. doi:<a href=\"https://doi.org/10.1007/BFb0027241\">10.1007/BFb0027241</a>","apa":"Henzinger, T. A., &#38; Wong Toi, H. (1996). Using HyTech to synthesize control parameters for a steam boiler. In <i>Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control</i> (Vol. 1165, pp. 265–282). Springer. <a href=\"https://doi.org/10.1007/BFb0027241\">https://doi.org/10.1007/BFb0027241</a>","short":"T.A. Henzinger, H. Wong Toi, in:, Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control, Springer, 1996, pp. 265–282."},"status":"public","intvolume":"      1165","quality_controlled":"1","publication":"Formal Methods for Industrial Applications: Specifying and Programming the Steam Boiler Control","publisher":"Springer","date_created":"2018-12-11T12:08:48Z","extern":"1","month":"01","page":"265 - 282","publication_identifier":{"isbn":["9783540495666"]},"date_updated":"2022-07-06T10:06:19Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","year":"1996","publist_id":"303","volume":1165,"main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/BFb0027241"}],"publication_status":"published","date_published":"1996-01-01T00:00:00Z","_id":"4427","abstract":[{"lang":"eng","text":"We model a steam-boiler control system using hybrid automata. We provide two abstracted linear models of the nonlinear behavior of the boiler. For each model, we define and verify a controller that maintains safe operation of the boiler. The less abstract model permits the design of a more efficient controller. We also demonstrate how the tool HyTech can be used to automatically synthesize control parameter constraints that guarantee safety of the boiler."}],"article_processing_charge":"No"},{"publist_id":"288","oa_version":"None","year":"1996","date_updated":"2022-07-06T08:43:23Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"isbn":["9783540616047"]},"date_published":"1996-01-01T00:00:00Z","_id":"4443","abstract":[{"lang":"eng","text":"Three natural equivalence relations on the infinite state space of a hybrid automaton are language equivalence, simulation equivalence, and bisimulation equivalence. When one of these equivalence relations has a finite quotient, certain model checking and controller synthesis problems are decidable. When bounds on the number of equivalence classes are obtained, bounds on the running times of model checking and synthesis algorithms follow as corollaries.\r\nWe characterize the time-abstract versions of these equivalence relations on the state spaces of rectangular hybrid automata (RHA), in which each continuous variable is a clock with bounded drift. These automata are useful for modeling communications protocols with drifting local clocks, and for the conservative approximation of more complex hybrid systems. Of our two main results, one has positive implications for automatic verification, and the other has negative implications. On the positive side, we find that the (finite) language equivalence quotient for RHA is coarser than was previously known by a multiplicative exponential factor. On the negative side, we show that simulation equivalence for RHA is equality (which obviously has an infinite quotient).\r\nOur main positive result is established by analyzing a subclass of timed automata, called one-sided timed automata (OTA), for which the language equivalence quotient is coarser than for the class of all timed automata. An exact characterization of language equivalence for OTA requires a distinction between synchronous and asynchronous definitions of (bi)simulation: if time actions are silent, then the induced quotient for OTA is coarser than if time actions (but not their durations) are visible."}],"article_processing_charge":"No","volume":1119,"publication_status":"published","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-61604-7_74"}],"day":"01","author":[{"orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A"},{"full_name":"Kopke, Peter","first_name":"Peter","last_name":"Kopke"}],"type":"conference","alternative_title":["LNCS"],"citation":{"chicago":"Henzinger, Thomas A, and Peter Kopke. “State Equivalences for Rectangular Hybrid Automata.” In <i>7th International Conference on Concurrency Theory</i>, 1119:530–45. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996. <a href=\"https://doi.org/10.1007/3-540-61604-7_74\">https://doi.org/10.1007/3-540-61604-7_74</a>.","ista":"Henzinger TA, Kopke P. 1996. State equivalences for rectangular hybrid automata. 7th International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS, vol. 1119, 530–545.","ieee":"T. A. Henzinger and P. Kopke, “State equivalences for rectangular hybrid automata,” in <i>7th International Conference on Concurrency Theory</i>, Pisa, Italy, 1996, vol. 1119, pp. 530–545.","mla":"Henzinger, Thomas A., and Peter Kopke. “State Equivalences for Rectangular Hybrid Automata.” <i>7th International Conference on Concurrency Theory</i>, vol. 1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–45, doi:<a href=\"https://doi.org/10.1007/3-540-61604-7_74\">10.1007/3-540-61604-7_74</a>.","short":"T.A. Henzinger, P. Kopke, in:, 7th International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 530–545.","ama":"Henzinger TA, Kopke P. State equivalences for rectangular hybrid automata. In: <i>7th International Conference on Concurrency Theory</i>. Vol 1119. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1996:530-545. doi:<a href=\"https://doi.org/10.1007/3-540-61604-7_74\">10.1007/3-540-61604-7_74</a>","apa":"Henzinger, T. A., &#38; Kopke, P. (1996). State equivalences for rectangular hybrid automata. In <i>7th International Conference on Concurrency Theory</i> (Vol. 1119, pp. 530–545). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.1007/3-540-61604-7_74\">https://doi.org/10.1007/3-540-61604-7_74</a>"},"title":"State equivalences for rectangular hybrid automata","conference":{"location":"Pisa, Italy","name":"CONCUR: Concurrency Theory","start_date":"1996-08-26","end_date":"1996-08-29"},"language":[{"iso":"eng"}],"doi":"10.1007/3-540-61604-7_74","acknowledgement":"This research was supported in part by ONR Young Investigator award N00014-95-1-0520, by NSF CAREER award CCR-9501708, by NSF grant CCR-9504469, by Air Force Office of Scientific Research contract F49620-93-1-0056, by ARPA grant NAG2-892, and by the U.S. Army Research Office through the Mathematical Sciences Institute of Cornell University, Contract Number DAAL03-91-C-0027.","month":"01","extern":"1","date_created":"2018-12-11T12:08:52Z","page":"530 - 545","publication":"7th International Conference on Concurrency Theory","quality_controlled":"1","status":"public","intvolume":"      1119","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik"},{"article_processing_charge":"No","_id":"4495","date_published":"1996-01-01T00:00:00Z","abstract":[{"lang":"eng","text":"In temporal-logic model checking, we verify the correctness of a program with respect to a desired behavior by checking whether a structure that models the program satisfies a temporal-logic formula that specifies the behavior. The main practical limitation of model checking is caused by the size of the state space of the program, which grows exponentially with the number of concurrent components. This problem, known as the state-explosion problem, becomes more difficult when we consider real-time model checking, where the program and the specification involve quantitative references to time. In particular, when use timed automata to describe real-time programs and we specify timed behaviors in the logic TCTL, a real-time extension of the temporal logic CTL with clock variables, then the state space under consideration grows exponentially not only with the number of concurrent components, but also with the number of clocks and the length of the clock constraints used in the program and the specification. Two powerful methods for coping with the state-explosion problem are on-the-fly and space-efficient model checking. In on-the-fly model checking, we explore only the portion of the state space of the program whose exploration is essential for determining the satisfaction of the specification. In space-efficient model checking, we store in memory the minimal information required, preferring to spend time on reconstructing information rather than spend space on storing it. In this work we develop an automata-theoretic approach to TCTL model checking that combines both methods. We suggest, for the first time, a PSPACE on-the-fly model-checking algorithm for TCTL."}],"main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/3-540-61604-7_73"}],"publication_status":"published","volume":1119,"oa_version":"None","year":"1996","publist_id":"233","publication_identifier":{"isbn":["978-3-540-70625-0"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-07-06T08:21:20Z","page":"514 - 529","date_created":"2018-12-11T12:09:08Z","extern":"1","month":"01","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","intvolume":"      1119","status":"public","quality_controlled":"1","publication":"7th International Conference on Concurrency Theory","conference":{"name":"CONCUR: Concurrency Theory","end_date":"1996-08-29","start_date":"1996-08-26","location":"Pisa, Italy"},"title":"A space-efficient on-the-fly algorithm for real-time model checking","citation":{"mla":"Henzinger, Thomas A., et al. “A Space-Efficient on-the-Fly Algorithm for Real-Time Model Checking.” <i>7th International Conference on Concurrency Theory</i>, vol. 1119, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 514–29, doi:<a href=\"https://doi.org/10.1007/3-540-61604-7_73\">10.1007/3-540-61604-7_73</a>.","chicago":"Henzinger, Thomas A, Orna Kupferman, and Moshe Vardi. “A Space-Efficient on-the-Fly Algorithm for Real-Time Model Checking.” In <i>7th International Conference on Concurrency Theory</i>, 1119:514–29. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996. <a href=\"https://doi.org/10.1007/3-540-61604-7_73\">https://doi.org/10.1007/3-540-61604-7_73</a>.","ista":"Henzinger TA, Kupferman O, Vardi M. 1996. A space-efficient on-the-fly algorithm for real-time model checking. 7th International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS, vol. 1119, 514–529.","ieee":"T. A. Henzinger, O. Kupferman, and M. Vardi, “A space-efficient on-the-fly algorithm for real-time model checking,” in <i>7th International Conference on Concurrency Theory</i>, Pisa, Italy, 1996, vol. 1119, pp. 514–529.","ama":"Henzinger TA, Kupferman O, Vardi M. A space-efficient on-the-fly algorithm for real-time model checking. In: <i>7th International Conference on Concurrency Theory</i>. Vol 1119. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1996:514-529. doi:<a href=\"https://doi.org/10.1007/3-540-61604-7_73\">10.1007/3-540-61604-7_73</a>","apa":"Henzinger, T. A., Kupferman, O., &#38; Vardi, M. (1996). A space-efficient on-the-fly algorithm for real-time model checking. In <i>7th International Conference on Concurrency Theory</i> (Vol. 1119, pp. 514–529). Pisa, Italy: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.1007/3-540-61604-7_73\">https://doi.org/10.1007/3-540-61604-7_73</a>","short":"T.A. Henzinger, O. Kupferman, M. Vardi, in:, 7th International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1996, pp. 514–529."},"alternative_title":["LNCS"],"type":"conference","author":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","last_name":"Henzinger","full_name":"Henzinger, Thomas A","first_name":"Thomas A"},{"first_name":"Orna","full_name":"Kupferman, Orna","last_name":"Kupferman"},{"last_name":"Vardi","full_name":"Vardi, Moshe","first_name":"Moshe"}],"day":"01","acknowledgement":"Supported in part by the ONR YIP award N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR contract F49620-93-1-0056, and by the ARPA grant NAG2-892.","doi":"10.1007/3-540-61604-7_73","language":[{"iso":"eng"}]},{"conference":{"location":"New Brunswick, NJ, United States of America","start_date":"1996-07-27","end_date":"1996-07-30","name":"LICS: Logic in Computer Science"},"title":"The theory of hybrid automata","citation":{"mla":"Henzinger, Thomas A. “The Theory of Hybrid Automata.” <i>Proceedings 11th Annual IEEE Symposium on Logic in Computer Science</i>, IEEE, 1996, pp. 278–92, doi:<a href=\"https://doi.org/10.1109/LICS.1996.561342 \">10.1109/LICS.1996.561342 </a>.","ieee":"T. A. Henzinger, “The theory of hybrid automata,” in <i>Proceedings 11th Annual IEEE Symposium on Logic in Computer Science</i>, New Brunswick, NJ, United States of America, 1996, pp. 278–292.","ista":"Henzinger TA. 1996. The theory of hybrid automata. Proceedings 11th Annual IEEE Symposium on Logic in Computer Science. LICS: Logic in Computer Science, 278–292.","chicago":"Henzinger, Thomas A. “The Theory of Hybrid Automata.” In <i>Proceedings 11th Annual IEEE Symposium on Logic in Computer Science</i>, 278–92. IEEE, 1996. <a href=\"https://doi.org/10.1109/LICS.1996.561342 \">https://doi.org/10.1109/LICS.1996.561342 </a>.","apa":"Henzinger, T. A. (1996). The theory of hybrid automata. In <i>Proceedings 11th Annual IEEE Symposium on Logic in Computer Science</i> (pp. 278–292). New Brunswick, NJ, United States of America: IEEE. <a href=\"https://doi.org/10.1109/LICS.1996.561342 \">https://doi.org/10.1109/LICS.1996.561342 </a>","ama":"Henzinger TA. The theory of hybrid automata. In: <i>Proceedings 11th Annual IEEE Symposium on Logic in Computer Science</i>. IEEE; 1996:278-292. doi:<a href=\"https://doi.org/10.1109/LICS.1996.561342 \">10.1109/LICS.1996.561342 </a>","short":"T.A. Henzinger, in:, Proceedings 11th Annual IEEE Symposium on Logic in Computer Science, IEEE, 1996, pp. 278–292."},"oa_version":"None","year":"1996","type":"conference","author":[{"orcid":"0000−0002−2985−7724","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A"}],"day":"01","publist_id":"213","doi":"10.1109/LICS.1996.561342 ","publication_identifier":{"issn":["1043-6871"]},"language":[{"iso":"eng"}],"date_updated":"2022-07-06T07:56:28Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","page":"278 - 292","_id":"4519","abstract":[{"text":"We summarize several recent results about hybrid automata. Our goal is to demonstrate that concepts from the theory of discrete concurrent systems can give insights into partly continuous systems, and that methods for the verification of finite-state systems can be used to analyze certain systems with uncountable state spaces","lang":"eng"}],"date_created":"2018-12-11T12:09:16Z","date_published":"1996-01-01T00:00:00Z","extern":"1","month":"01","main_file_link":[{"url":"https://ieeexplore.ieee.org/document/561342"}],"publication_status":"published","publisher":"IEEE","status":"public","quality_controlled":"1","publication":"Proceedings 11th Annual IEEE Symposium on Logic in Computer Science"},{"abstract":[{"text":"Auxins play a crucial role in the regulation of spatial and temporal aspects of plant growth and development1. As well as being required for the division, enlargement and differentiation of individual plant cells, auxins also function as signals between cells, tissues and organs. In this way they contribute to the coordination and integration of growth and development in the whole plant and to physiological responses of plants to environmental cues (63). At the individual cell level, fast changes or pulses in hormone concentration may function to initiate or to terminate a developmental process. In contrast, the maintenance of a stable concentration of the hormone (homeostasis) may be necessary to maintain the progress of a developmental event that has already been initiated.","lang":"eng"}],"_id":"2465","date_published":"1995-01-01T00:00:00Z","date_created":"2018-12-11T11:57:49Z","month":"01","extern":"1","article_processing_charge":"No","page":"451 - 484","status":"public","publication":"Plant Hormones: Biosynthesis, Signal Transduction, Action!","quality_controlled":"1","main_file_link":[{"url":"https://link.springer.com/chapter/10.1007/978-1-4020-2686-7_21"}],"publication_status":"published","publisher":"Kluwer","author":[{"last_name":"Morris","full_name":"Morris, David","first_name":"David"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jirí","first_name":"Jirí"},{"full_name":"Zažímalová, Eva","first_name":"Eva","last_name":"Zažímalová"}],"type":"book_chapter","oa_version":"None","year":"1995","publist_id":"4438","day":"01","title":"Auxin transport","editor":[{"last_name":"Davies","full_name":"Davies, Peter","first_name":"Peter"}],"citation":{"mla":"Morris, David, et al. “Auxin Transport.” <i>Plant Hormones: Biosynthesis, Signal Transduction, Action!</i>, edited by Peter Davies, Kluwer, 1995, pp. 451–84, doi:<a href=\"https://doi.org/10.1007/978-1-4020-2686-7_21\">10.1007/978-1-4020-2686-7_21</a>.","chicago":"Morris, David, Jiří Friml, and Eva Zažímalová. “Auxin Transport.” In <i>Plant Hormones: Biosynthesis, Signal Transduction, Action!</i>, edited by Peter Davies, 451–84. Kluwer, 1995. <a href=\"https://doi.org/10.1007/978-1-4020-2686-7_21\">https://doi.org/10.1007/978-1-4020-2686-7_21</a>.","ieee":"D. Morris, J. Friml, and E. Zažímalová, “Auxin transport,” in <i>Plant Hormones: Biosynthesis, Signal Transduction, Action!</i>, P. Davies, Ed. Kluwer, 1995, pp. 451–484.","ista":"Morris D, Friml J, Zažímalová E. 1995.Auxin transport. In: Plant Hormones: Biosynthesis, Signal Transduction, Action! , 451–484.","ama":"Morris D, Friml J, Zažímalová E. Auxin transport. In: Davies P, ed. <i>Plant Hormones: Biosynthesis, Signal Transduction, Action!</i>. Kluwer; 1995:451-484. doi:<a href=\"https://doi.org/10.1007/978-1-4020-2686-7_21\">10.1007/978-1-4020-2686-7_21</a>","apa":"Morris, D., Friml, J., &#38; Zažímalová, E. (1995). Auxin transport. In P. Davies (Ed.), <i>Plant Hormones: Biosynthesis, Signal Transduction, Action!</i> (pp. 451–484). Kluwer. <a href=\"https://doi.org/10.1007/978-1-4020-2686-7_21\">https://doi.org/10.1007/978-1-4020-2686-7_21</a>","short":"D. Morris, J. Friml, E. Zažímalová, in:, P. Davies (Ed.), Plant Hormones: Biosynthesis, Signal Transduction, Action!, Kluwer, 1995, pp. 451–484."},"publication_identifier":{"isbn":["978-1-4020-2684-3"]},"doi":"10.1007/978-1-4020-2686-7_21","scopus_import":"1","language":[{"iso":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-29T14:45:32Z"},{"date_created":"2018-12-11T11:57:59Z","extern":"1","month":"10","page":"555 - 570","intvolume":"       360","status":"public","quality_controlled":"1","publication":"Journal of Comparative Neurology","publisher":"Wiley-Blackwell","author":[{"last_name":"Ohishi","full_name":"Ohishi, Hitoshi","first_name":"Hitoshi"},{"first_name":"Chihiro","full_name":"Akazawa, Chihiro","last_name":"Akazawa"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"last_name":"Mizuno","first_name":"Noboru","full_name":"Mizuno, Noboru"}],"type":"journal_article","day":"02","title":"Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain","citation":{"ista":"Ohishi H, Akazawa C, Shigemoto R, Nakanishi S, Mizuno N. 1995. Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. Journal of Comparative Neurology. 360(4), 555–570.","ieee":"H. Ohishi, C. Akazawa, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain,” <i>Journal of Comparative Neurology</i>, vol. 360, no. 4. Wiley-Blackwell, pp. 555–570, 1995.","chicago":"Ohishi, Hitoshi, Chihiro Akazawa, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Distributions of the MRNAs for L-2-Amino-4-Phosphonobutyrate-Sensitive Metabotropic Glutamate Receptors, MGluR4 and MGluR7, in the Rat Brain.” <i>Journal of Comparative Neurology</i>. Wiley-Blackwell, 1995. <a href=\"https://doi.org/10.1002/cne.903600402\">https://doi.org/10.1002/cne.903600402</a>.","mla":"Ohishi, Hitoshi, et al. “Distributions of the MRNAs for L-2-Amino-4-Phosphonobutyrate-Sensitive Metabotropic Glutamate Receptors, MGluR4 and MGluR7, in the Rat Brain.” <i>Journal of Comparative Neurology</i>, vol. 360, no. 4, Wiley-Blackwell, 1995, pp. 555–70, doi:<a href=\"https://doi.org/10.1002/cne.903600402\">10.1002/cne.903600402</a>.","short":"H. Ohishi, C. Akazawa, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative Neurology 360 (1995) 555–570.","apa":"Ohishi, H., Akazawa, C., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1995). Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. <i>Journal of Comparative Neurology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1002/cne.903600402\">https://doi.org/10.1002/cne.903600402</a>","ama":"Ohishi H, Akazawa C, Shigemoto R, Nakanishi S, Mizuno N. Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. <i>Journal of Comparative Neurology</i>. 1995;360(4):555-570. doi:<a href=\"https://doi.org/10.1002/cne.903600402\">10.1002/cne.903600402</a>"},"doi":"10.1002/cne.903600402","language":[{"iso":"eng"}],"acknowledgement":"We are grateful  to Akira Uesugi for photographic help. This work has been supported in part by research grants from the Ministry of Education, Science and  Culture of Japan.","pmid":1,"_id":"2491","abstract":[{"text":"The distribution of mRNAs for metabotropic glutamate receptors, mGluR4 and mGluR7, which are highly sensitive for L-2-amino-4-phosphonobutyrate (L- AP4), was examined in the central nervous system of the rat by in situ hybridization. In general, the hybridization signals of mGluR7 mRNA were more widely distributed than those of mGluR4 mRNA, and differential expression of mGluR4 mRNA and mGluR7 mRNA was clearly indicated in some brain regions. Intense or moderate expression of mGluR4 mRNA was detected in the granule cells of the olfactory bulb and cerebellum, whereas no significant expression of mGluR7 mRNA was found in these cells. In other neurons or regions where mGluR7 mRNA was intensely or moderately expressed, no significant expression of mGluR4 mRNA was observed. Such were the mitral and tufted cells of the olfactory bulb; anterior olfactory nucleus; neocortical regions; cingulate cortex; retrosplenial cortex; piriform cortex; perirhinal cortex; CA1; CA3; granule cells of the dentate gyrus; superficial layers of the subicular cortex; deep layers of the entorhinal, parasubicular, and presubicular cortices; ventral part of the lateral septal nucleus; septohippocampal nucleus; triangular septal nucleus; nuclei of the diagonal band; bed nucleus of the stria terminalis; ventral pallidum; claustrum; amygdaloid nuclei other than the intercalated nuclei; preoptic region; hypothalamic nuclei other than the medial mammillary nucleus; ventral lateral geniculate nucleus; locus coeruleus; Purkinje cells; many nuclei of the lower brainstem other than the superior colliculus, periaqueductal gray, interpeduncular nucleus, pontine nuclei, and dorsal cochlear nucleus; and dorsal horn of the spinal cord. Both mGluR4 mRNA and mGluR7 mRNA were moderately or intensely expressed in the olfactory tubercle, superficial layers of the entorhinal cortex, CA4, septofimbrial nucleus, intercalated nuclei of the amygdala, medial mammillary nucleus, many thalamic nuclei, and pontine nuclei. Intense expression of both mGluR4 mRNA and mGluR7 mRNA was further detected in the trigeminal ganglion and dorsal root ganglia, whereas no significant expression of them was found in the pterygopalatine ganglion and superior cervical ganglion. The results indicate differential roles of the L-AP4-sensitive metabotropic glutamate receptors in the glutamatergic nervous system.","lang":"eng"}],"date_published":"1995-10-02T00:00:00Z","issue":"4","article_processing_charge":"No","volume":360,"main_file_link":[{"url":"https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.903600402"}],"publication_status":"published","year":"1995","oa_version":"None","publist_id":"4410","article_type":"original","publication_identifier":{"issn":["0021-9967"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-29T13:08:19Z","external_id":{"pmid":["8801249"]},"scopus_import":"1"},{"month":"03","extern":"1","date_created":"2018-12-11T11:58:22Z","page":"336 - 340","publication":"Brain Research","quality_controlled":"1","intvolume":"       674","status":"public","publisher":"Elsevier","day":"20","author":[{"first_name":"Yu","full_name":"Ding, Yu","last_name":"Ding"},{"last_name":"Takada","full_name":"Takada, Masahiko","first_name":"Masahiko"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"full_name":"Mizuno, Noboru","first_name":"Noboru","last_name":"Mizuno"}],"type":"journal_article","citation":{"ista":"Ding Y, Takada M, Shigemoto R, Mizuno N. 1995. Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat. Brain Research. 674(2), 336–340.","ieee":"Y. Ding, M. Takada, R. Shigemoto, and N. Mizuno, “Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat,” <i>Brain Research</i>, vol. 674, no. 2. Elsevier, pp. 336–340, 1995.","chicago":"Ding, Yu, Masahiko Takada, Ryuichi Shigemoto, and Noboru Mizuno. “Spinoparabrachial Tract Neurons Showing Substance P Receptor-like Immunoreactivity in the Lumbar Spinal Cord of the Rat.” <i>Brain Research</i>. Elsevier, 1995. <a href=\"https://doi.org/10.1016/0006-8993(95)00022-I\">https://doi.org/10.1016/0006-8993(95)00022-I</a>.","mla":"Ding, Yu, et al. “Spinoparabrachial Tract Neurons Showing Substance P Receptor-like Immunoreactivity in the Lumbar Spinal Cord of the Rat.” <i>Brain Research</i>, vol. 674, no. 2, Elsevier, 1995, pp. 336–40, doi:<a href=\"https://doi.org/10.1016/0006-8993(95)00022-I\">10.1016/0006-8993(95)00022-I</a>.","short":"Y. Ding, M. Takada, R. Shigemoto, N. Mizuno, Brain Research 674 (1995) 336–340.","apa":"Ding, Y., Takada, M., Shigemoto, R., &#38; Mizuno, N. (1995). Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat. <i>Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/0006-8993(95)00022-I\">https://doi.org/10.1016/0006-8993(95)00022-I</a>","ama":"Ding Y, Takada M, Shigemoto R, Mizuno N. Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat. <i>Brain Research</i>. 1995;674(2):336-340. doi:<a href=\"https://doi.org/10.1016/0006-8993(95)00022-I\">10.1016/0006-8993(95)00022-I</a>"},"title":"Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat","language":[{"iso":"eng"}],"doi":"10.1016/0006-8993(95)00022-I","pmid":1,"acknowledgement":"The authors are grateful for photographic help of Mr. Akira Uesugi. This work was supported in part by Grants-in-Aid for Special Research on Priority Areas 05267104, Scientific Research (B) 05454658, and Scientific Research (C) 06680735 from the Ministry of Education, Science and Culture of Japan.","abstract":[{"text":"By using substance P receptor (SPR) immunofluorescence histochemistry combined with fluorescent retrograde labeling, SPR-like immunoreactive (SPR-LI) neurons sending their axons to the lateral parabrachial region were observed in the lumbar spinal cord of the rat. After injection of Fluoro-Gold into the lateral parabrachial region, retrogradely labeled neurons with SPR-LI were seen frequently in lamina I and the lateral spinal nucleus, and occasionally in laminae IV and V, with a predominantly contralateral distribution. Some of these neurons, especially those in lamina I, may convey nociceptive information to the lateral parabrachial region.","lang":"eng"}],"_id":"2556","date_published":"1995-03-20T00:00:00Z","article_processing_charge":"No","issue":"2","volume":674,"publication_status":"published","main_file_link":[{"url":"sciencedirect.com/science/article/pii/000689939500022I?via%3Dihub"}],"article_type":"original","publist_id":"4341","year":"1995","oa_version":"None","external_id":{"pmid":["7796113"]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-29T08:32:01Z","publication_identifier":{"issn":["0006-8993"]}},{"publisher":"Gauthier Villars Editeur","publication":"Comptes Rendus de l'Academie des Sciences - Series III","quality_controlled":"1","intvolume":"       318","status":"public","page":"209 - 217","month":"02","extern":"1","date_created":"2018-12-11T11:58:23Z","pmid":1,"language":[{"iso":"eng"}],"citation":{"mla":"Mick, Gérard, et al. “Localization of Substance P Receptors in Central Neural Structures Controlling Daily Rhythms in Nocturnal Rodents.” <i>Comptes Rendus de l’Academie Des Sciences - Series III</i>, vol. 318, no. 2, Gauthier Villars Editeur, 1995, pp. 209–17.","chicago":"Mick, Gérard, Ryuichi Shigemoto, and Kunio Kitahama. “Localization of Substance P Receptors in Central Neural Structures Controlling Daily Rhythms in Nocturnal Rodents.” <i>Comptes Rendus de l’Academie Des Sciences - Series III</i>. Gauthier Villars Editeur, 1995.","ista":"Mick G, Shigemoto R, Kitahama K. 1995. Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. Comptes Rendus de l’Academie des Sciences - Series III. 318(2), 209–217.","ieee":"G. Mick, R. Shigemoto, and K. Kitahama, “Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents,” <i>Comptes Rendus de l’Academie des Sciences - Series III</i>, vol. 318, no. 2. Gauthier Villars Editeur, pp. 209–217, 1995.","ama":"Mick G, Shigemoto R, Kitahama K. Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. <i>Comptes Rendus de l’Academie des Sciences - Series III</i>. 1995;318(2):209-217.","apa":"Mick, G., Shigemoto, R., &#38; Kitahama, K. (1995). Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents. <i>Comptes Rendus de l’Academie Des Sciences - Series III</i>. Gauthier Villars Editeur.","short":"G. Mick, R. Shigemoto, K. Kitahama, Comptes Rendus de l’Academie Des Sciences - Series III 318 (1995) 209–217."},"title":"Localization of substance P receptors in central neural structures controlling daily rhythms in nocturnal rodents","day":"01","type":"journal_article","author":[{"first_name":"Gérard","full_name":"Mick, Gérard","last_name":"Mick"},{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"},{"last_name":"Kitahama","first_name":"Kunio","full_name":"Kitahama, Kunio"}],"publication_status":"published","main_file_link":[{"url":"https://pubmed.ncbi.nlm.nih.gov/7757814/"}],"volume":318,"article_processing_charge":"No","issue":"2","date_published":"1995-02-01T00:00:00Z","_id":"2558","abstract":[{"lang":"eng","text":"Brain areas involved in the genesis and control of daily rhythms receive a prominent neural input that contains the neurotransmitter substance P (SP), a peptide putatively involved in the synchronization of circadian rhythms by environmental light. We investigated the localization of receptors to SP in the suprachiasmatic nucleus of the hypothalamus (SCN) and in the intergeniculate leaflet of the thalamus (IGL) of the rat and hamster using in situ hybridization histochemistry and immunohistochemistry. Consistently with that previously described in the rat, a neuronal population distributed along the lateral margin and at the dorso-latero-caudal aspect of the hamster SCN expresses moderately the mRNA encoding the SP receptor. In both rat and hamster, immunohistochemical data confirm the previous finding and reveal an almost complete absence of SP receptors in the ventral part of the SCN, which receives a direct projection from the retina. In the IGL of both species, numerous neurons prominently express the mRNA encoding the SP receptor. The immunostaining shows a high density of SP receptors on perikarya and dendrites throughout the nucleus. A dense staining is also observed on individual cells and processes bordering the lumen of blood vessels in the SCN and IGL."}],"external_id":{"pmid":["7757814 "]},"scopus_import":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-29T08:18:48Z","publication_identifier":{"issn":["0764-4469"]},"article_type":"original","publist_id":"4340","year":"1995","oa_version":"None"},{"volume":80,"main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/0092867495903542"}],"oa":1,"publication_status":"published","abstract":[{"text":"Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGIuR6) in retinal ON bipolar cells, we generated knockout mice lacking mGIuR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious changes in retinal cell organization nor in the projection of optic fibers to the brain. Furthermore, the mGIuR6-deficient mice showed visual behavioral responses to light stimulation as examined by shuttle box avoidance behavior experiments using light exposure as a conditioned stimulus. The results demonstrate that mGIuR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information.","lang":"eng"}],"_id":"2559","date_published":"1995-02-10T00:00:00Z","issue":"5","article_processing_charge":"No","publication_identifier":{"issn":["0092-8674"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-06-28T13:27:50Z","external_id":{"pmid":["7889569"]},"year":"1995","oa_version":"Published Version","publist_id":"4339","article_type":"original","status":"public","intvolume":"        80","quality_controlled":"1","publication":"Cell","publisher":"Cell Press","date_created":"2018-12-11T11:58:23Z","extern":"1","month":"02","page":"757 - 765","doi":"10.1016/0092-8674(95)90354-2","language":[{"iso":"eng"}],"acknowledgement":"We thank Drs. N. Mizuno, M. Iso, M. Tachibana, A. Kaneko, M. Tessier-Lavigne, and T. Hensch for useful advice and A. Uesugi for photographic assistance. This work is supported by grants in aid for specially promoted research, for scientific research on priority areas, and for scientific research (A) from the Ministry of Education, Science, and Culture in Japan and by grants from the Ministry of Health and Welfare of Japan, the Sankyo Foundation, and the Senri Life Science Foundation.","pmid":1,"author":[{"last_name":"Masu","first_name":"Masayuki","full_name":"Masu, Masayuki"},{"last_name":"Iwakabe","first_name":"Hideki","full_name":"Iwakabe, Hideki"},{"full_name":"Tagawa, Yoshiaki","first_name":"Yoshiaki","last_name":"Tagawa"},{"full_name":"Miyoshi, Tomomitsu","first_name":"Tomomitsu","last_name":"Miyoshi"},{"first_name":"Masayuki","full_name":"Yamashita, Masayuki","last_name":"Yamashita"},{"last_name":"Fukuda","first_name":"Yutaka","full_name":"Fukuda, Yutaka"},{"last_name":"Sasaki","full_name":"Sasaki, Hitoshi","first_name":"Hitoshi"},{"last_name":"Hiroi","full_name":"Hiroi, Kano","first_name":"Kano"},{"full_name":"Nakamura, Yasuhisa","first_name":"Yasuhisa","last_name":"Nakamura"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Takada","full_name":"Takada, Masahiko","first_name":"Masahiko"},{"last_name":"Nakamura","first_name":"Kenji","full_name":"Nakamura, Kenji"},{"full_name":"Nakao, Kazuki","first_name":"Kazuki","last_name":"Nakao"},{"last_name":"Katsuki","first_name":"Motoya","full_name":"Katsuki, Motoya"},{"last_name":"Nakanishi","full_name":"Nakanishi, Shigetada","first_name":"Shigetada"}],"type":"journal_article","day":"10","title":"Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene","citation":{"short":"M. Masu, H. Iwakabe, Y. Tagawa, T. Miyoshi, M. Yamashita, Y. Fukuda, H. Sasaki, K. Hiroi, Y. Nakamura, R. Shigemoto, M. Takada, K. Nakamura, K. Nakao, M. Katsuki, S. Nakanishi, Cell 80 (1995) 757–765.","apa":"Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y., … Nakanishi, S. (1995). Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. <i>Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">https://doi.org/10.1016/0092-8674(95)90354-2</a>","ama":"Masu M, Iwakabe H, Tagawa Y, et al. Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. <i>Cell</i>. 1995;80(5):757-765. doi:<a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">10.1016/0092-8674(95)90354-2</a>","ieee":"M. Masu <i>et al.</i>, “Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene,” <i>Cell</i>, vol. 80, no. 5. Cell Press, pp. 757–765, 1995.","ista":"Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S. 1995. Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene. Cell. 80(5), 757–765.","chicago":"Masu, Masayuki, Hideki Iwakabe, Yoshiaki Tagawa, Tomomitsu Miyoshi, Masayuki Yamashita, Yutaka Fukuda, Hitoshi Sasaki, et al. “Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the MGIuR6 Gene.” <i>Cell</i>. Cell Press, 1995. <a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">https://doi.org/10.1016/0092-8674(95)90354-2</a>.","mla":"Masu, Masayuki, et al. “Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the MGIuR6 Gene.” <i>Cell</i>, vol. 80, no. 5, Cell Press, 1995, pp. 757–65, doi:<a href=\"https://doi.org/10.1016/0092-8674(95)90354-2\">10.1016/0092-8674(95)90354-2</a>."}}]