[{"language":[{"iso":"eng"}],"month":"12","oa_version":"None","publication":"Development","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1933","publication_identifier":{"issn":["0950-1991"]},"date_published":"1996-12-01T00:00:00Z","type":"journal_article","article_type":"original","publisher":"Company of Biologists","page":"369 - 389","quality_controlled":"1","title":"Zebrafish pigmentation mutations and the processes of neural crest development","intvolume":"       123","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:28Z","author":[{"last_name":"Kelsh","first_name":"Robert","full_name":"Kelsh, Robert"},{"full_name":"Brand, Michael","last_name":"Brand","first_name":"Michael"},{"full_name":"Jiang, Yunjin","first_name":"Yunjin","last_name":"Jiang"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Shuo","last_name":"Lin","full_name":"Lin, Shuo"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"full_name":"Van Eeden, Fredericus","last_name":"Van Eeden","first_name":"Fredericus"},{"first_name":"Makoto","last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto"},{"first_name":"Michael","last_name":"Granato","full_name":"Granato, Michael"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"first_name":"Dirk","last_name":"Beuchle","full_name":"Beuchle, Dirk"},{"last_name":"Vogelsang","first_name":"Lisa","full_name":"Vogelsang, Lisa"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"issue":"1","_id":"4186","pmid":1,"scopus_import":"1","extern":"1","volume":123,"acknowledgement":"We wish to thank Drs Judith Eisen, Steve Johnson, Dave Raible and Jim Weston for valuable comments. R. N. K. was supported by a NATO Postdoctoral Fellowship.","abstract":[{"lang":"eng","text":"Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation, Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development, As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation, By complementation analysis, we define 94 genes, We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected, Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation, Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation, Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation, 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival, In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development."}],"doi":"10.1242/dev.123.1.369","day":"01","external_id":{"pmid":["9007256 "]},"date_updated":"2022-08-05T11:16:49Z","citation":{"ista":"Kelsh R, Brand M, Jiang Y, Heisenberg C-PJ, Lin S, Haffter P, Odenthal J, Mullins M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Kane D, Warga R, Beuchle D, Vogelsang L, Nüsslein Volhard C. 1996. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 123(1), 369–389.","mla":"Kelsh, Robert, et al. “Zebrafish Pigmentation Mutations and the Processes of Neural Crest Development.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 369–89, doi:<a href=\"https://doi.org/10.1242/dev.123.1.369\">10.1242/dev.123.1.369</a>.","short":"R. Kelsh, M. Brand, Y. Jiang, C.-P.J. Heisenberg, S. Lin, P. Haffter, J. Odenthal, M. Mullins, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, D. Kane, R. Warga, D. Beuchle, L. Vogelsang, C. Nüsslein Volhard, Development 123 (1996) 369–389.","ieee":"R. Kelsh <i>et al.</i>, “Zebrafish pigmentation mutations and the processes of neural crest development,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 369–389, 1996.","chicago":"Kelsh, Robert, Michael Brand, Yunjin Jiang, Carl-Philipp J Heisenberg, Shuo Lin, Pascal Haffter, Jörg Odenthal, et al. “Zebrafish Pigmentation Mutations and the Processes of Neural Crest Development.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.369\">https://doi.org/10.1242/dev.123.1.369</a>.","ama":"Kelsh R, Brand M, Jiang Y, et al. Zebrafish pigmentation mutations and the processes of neural crest development. <i>Development</i>. 1996;123(1):369-389. doi:<a href=\"https://doi.org/10.1242/dev.123.1.369\">10.1242/dev.123.1.369</a>","apa":"Kelsh, R., Brand, M., Jiang, Y., Heisenberg, C.-P. J., Lin, S., Haffter, P., … Nüsslein Volhard, C. (1996). Zebrafish pigmentation mutations and the processes of neural crest development. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.369\">https://doi.org/10.1242/dev.123.1.369</a>"},"year":"1996"},{"date_published":"1996-12-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1930","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Development","oa_version":"None","month":"12","language":[{"iso":"eng"}],"date_updated":"2022-08-05T09:22:40Z","citation":{"apa":"Kane, D., Hammerschmidt, M., Mullins, M., Maischein, H., Brand, M., Van Eeden, F., … Nüsslein Volhard, C. (1996). The zebrafish epiboly mutants. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.47 \">https://doi.org/10.1242/dev.123.1.47 </a>","ama":"Kane D, Hammerschmidt M, Mullins M, et al. The zebrafish epiboly mutants. <i>Development</i>. 1996;123(1):47-55. doi:<a href=\"https://doi.org/10.1242/dev.123.1.47 \">10.1242/dev.123.1.47 </a>","ieee":"D. Kane <i>et al.</i>, “The zebrafish epiboly mutants,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 47–55, 1996.","chicago":"Kane, Donald, Matthias Hammerschmidt, Mary Mullins, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “The Zebrafish Epiboly Mutants.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.47 \">https://doi.org/10.1242/dev.123.1.47 </a>.","mla":"Kane, Donald, et al. “The Zebrafish Epiboly Mutants.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 47–55, doi:<a href=\"https://doi.org/10.1242/dev.123.1.47 \">10.1242/dev.123.1.47 </a>.","short":"D. Kane, M. Hammerschmidt, M. Mullins, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 47–55.","ista":"Kane D, Hammerschmidt M, Mullins M, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. The zebrafish epiboly mutants. Development. 123(1), 47–55."},"year":"1996","external_id":{"pmid":["9007228 "]},"doi":"10.1242/dev.123.1.47 ","day":"01","abstract":[{"text":"Epiboly, the enveloping of the yolk cell by the blastoderm, is the first zebrafish morphogenetic movement, We isolated four mutations that affect epiboly: half baked, avalanche, lawine and weg, Homozygous mutant embryos arrest the vegetal progress of the deep cells of the blastoderm; only the yolk syncytial layer of the yolk cell and the enveloping layer of the blastoderm reach the vegetal pole of the embryo, The mutations half baked, avalanche and lawine produce a novel dominant effect, termed a zygotic-maternal dominant effect: heterozygous embryos produced from heterozygous females slow down epiboly and accumulate detached cells over the neural tube; a small fraction of these mutant individuals are viable, Heterozygous embryos produced from heterozygous males crossed to homozygous wild-type females complete epiboly normally and are completely viable. Additionally, embryos heterozygous for half baked have an enlarged hatching gland, a partial dominant phenotype, The phenotypes of these mutants demonstrate that, for the spreading of cells during epiboly, the movement of the deep cells of the blastoderm require the function of genes that are not necessary for the movement of the enveloping layer or the yolk cell, Furthermore, the dominant zygotic-maternal effect phenotypes illustrate the maternal and zygotic interplay of genes that orchestrate the early cell movements of the zebrafish.","lang":"eng"}],"volume":123,"acknowledgement":"We thank Drs John Postlethwait and Sigfreid Roth for their helpful comments on earlier drafts of this paper. This work was supported in part by a grant from the National Institutes of Health to D. A. K.","extern":"1","_id":"4188","pmid":1,"scopus_import":"1","author":[{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"first_name":"Matthias","last_name":"Hammerschmidt","full_name":"Hammerschmidt, Matthias"},{"last_name":"Mullins","first_name":"Mary","full_name":"Mullins, Mary"},{"first_name":"Hans","last_name":"Maischein","full_name":"Maischein, Hans"},{"full_name":"Brand, Michael","last_name":"Brand","first_name":"Michael"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"last_name":"Granato","first_name":"Michael","full_name":"Granato, Michael"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg"},{"full_name":"Jiang, Yunjin","last_name":"Jiang","first_name":"Yunjin"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard","first_name":"Christiane"}],"issue":"1","publication_status":"published","date_created":"2018-12-11T12:07:29Z","article_processing_charge":"No","title":"The zebrafish epiboly mutants","intvolume":"       123","page":"47 - 55","quality_controlled":"1","publisher":"Company of Biologists","article_type":"original"},{"extern":"1","acknowledgement":"We thank Dr Adam Felsenfeld for his careful comments on earlier drafts of this manuscript, D. A. K. also thanks the two anonymous referees who patiently pointed out a number of ‘speed bumps’ in the first submitted draft of this manuscript. This work was supported in part by a grant from the National Institutes of Health to D. A. K.","volume":123,"abstract":[{"lang":"eng","text":"This report describes mutants of the zebrafish having phenotypes causing a general arrest in early morphogenesis. These mutants identify a group of loci making up about 20% of the loci identified by mutants with visible morphological phenotypes within the first day of development. There are 12 Class I mutants, which fall into 5 complementation groups and have cells that lyse before morphological defects are observed. Mutants at three loci, speed bump, ogre and zombie, display abnormal nuclei. The 8 Class II mutants, which fall into 6 complementation groups, arrest development before cell lysis is observed. These mutants seemingly stop development in the late segmentation stages, and maintain a body shape similar to a 20 hour embryo. Mutations in speed bump, ogre, zombie, specter, poltergeist and troll were tested for cell lethality by transplanting mutant cells into wild-type hosts. With poltergeist, transplanted mutant cells all survive. The remainder of the mutants tested were autonomously but conditionally lethal: mutant cells, most of which lyse, sometimes survive to become notochord, muscles, or, in rare cases, large neurons, all cell types which become postmitotic in the gastrula. Some of the genes of the early arrest group may be necessary for progression though the cell cycle; if so, the survival of early differentiating cells may be based on having their terminal mitosis before the zygotic requirement for these genes."}],"doi":"10.1242/dev.123.1.57 ","day":"01","external_id":{"pmid":["9007229 "]},"date_updated":"2022-08-05T09:43:44Z","year":"1996","citation":{"ista":"Kane D, Maischein H, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996. The zebrafish early arrest mutants. Development. 123(1), 57–66.","mla":"Kane, Donald, et al. “The Zebrafish Early Arrest Mutants.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 57–66, doi:<a href=\"https://doi.org/10.1242/dev.123.1.57 \">10.1242/dev.123.1.57 </a>.","short":"D. Kane, H. Maischein, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 57–66.","ieee":"D. Kane <i>et al.</i>, “The zebrafish early arrest mutants,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 57–66, 1996.","chicago":"Kane, Donald, Hans Maischein, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, Michael Granato, Pascal Haffter, et al. “The Zebrafish Early Arrest Mutants.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.57 \">https://doi.org/10.1242/dev.123.1.57 </a>.","ama":"Kane D, Maischein H, Brand M, et al. The zebrafish early arrest mutants. <i>Development</i>. 1996;123(1):57-66. doi:<a href=\"https://doi.org/10.1242/dev.123.1.57 \">10.1242/dev.123.1.57 </a>","apa":"Kane, D., Maischein, H., Brand, M., Van Eeden, F., Furutani Seiki, M., Granato, M., … Nüsslein Volhard, C. (1996). The zebrafish early arrest mutants. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.57 \">https://doi.org/10.1242/dev.123.1.57 </a>"},"article_type":"original","publisher":"Company of Biologists","page":"57 - 66","quality_controlled":"1","title":"The zebrafish early arrest mutants","intvolume":"       123","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:29Z","author":[{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"full_name":"Maischein, Hans","first_name":"Hans","last_name":"Maischein"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"first_name":"Michael","last_name":"Granato","full_name":"Granato, Michael"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Mullins, Mary","last_name":"Mullins","first_name":"Mary"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"full_name":"Warga, Rachel","first_name":"Rachel","last_name":"Warga"},{"last_name":"Nüsslein Volhard","first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane"}],"issue":"1","pmid":1,"_id":"4189","scopus_import":"1","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1931","publication_identifier":{"issn":["0950-1991"]},"date_published":"1996-12-01T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"month":"12","oa_version":"None","publication":"Development"},{"language":[{"iso":"eng"}],"publication":"Development","oa_version":"None","month":"12","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","type":"journal_article","date_published":"1996-12-01T00:00:00Z","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1926","quality_controlled":"1","page":"205 - 216","publisher":"Company of Biologists","article_type":"original","scopus_import":"1","_id":"4191","pmid":1,"issue":"1","author":[{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Beuchle, Dirk","first_name":"Dirk","last_name":"Beuchle"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"first_name":"Michael","last_name":"Granato","full_name":"Granato, Michael"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"full_name":"Kane, Donald","last_name":"Kane","first_name":"Donald"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"first_name":"Jörg","last_name":"Odenthal","full_name":"Odenthal, Jörg"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"date_created":"2018-12-11T12:07:30Z","article_processing_charge":"No","publication_status":"published","intvolume":"       123","title":"Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio","volume":123,"acknowledgement":"We would like to thank Vladimir Korzh, Stefan Krauss, Monte Westerfield, Tom Jessell, Mark Fishman, Eric Weinberg, Andreas Püschel, Trevor Jowett and Jóse Campos-Ortega for providing antibodies and cDNA clones. We thank Suresh Jesuthasan and Tanya Whitfield for many helpful suggestions on the manuscript. Y.-J. J. wants to thank Christian Müller and Ralf Rupp for their instructive discussion. Y.-J. J. is a predoctoral fellow supported by Deutscher Akademischer Austauschdienst (DAAD).","extern":"1","citation":{"short":"Y. Jiang, M. Brand, C.-P.J. Heisenberg, D. Beuchle, M. Furutani Seiki, R. Kelsh, R. Warga, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, M. Mullins, J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 205–216.","mla":"Jiang, Yunjin, et al. “Mutations Affecting Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 205–16, doi:<a href=\"https://doi.org/10.1242/dev.123.1.205\">10.1242/dev.123.1.205</a>.","ista":"Jiang Y, Brand M, Heisenberg C-PJ, Beuchle D, Furutani Seiki M, Kelsh R, Warga R, Granato M, Haffter P, Hammerschmidt M, Kane D, Mullins M, Odenthal J, Van Eeden F, Nüsslein Volhard C. 1996. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development. 123(1), 205–216.","ama":"Jiang Y, Brand M, Heisenberg C-PJ, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):205-216. doi:<a href=\"https://doi.org/10.1242/dev.123.1.205\">10.1242/dev.123.1.205</a>","apa":"Jiang, Y., Brand, M., Heisenberg, C.-P. J., Beuchle, D., Furutani Seiki, M., Kelsh, R., … Nüsslein Volhard, C. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.205\">https://doi.org/10.1242/dev.123.1.205</a>","ieee":"Y. Jiang <i>et al.</i>, “Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 205–216, 1996.","chicago":"Jiang, Yunjin, Michael Brand, Carl-Philipp J Heisenberg, Dirk Beuchle, Makoto Furutani Seiki, Robert Kelsh, Rachel Warga, et al. “Mutations Affecting Neurogenesis and Brain Morphology in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.205\">https://doi.org/10.1242/dev.123.1.205</a>."},"year":"1996","date_updated":"2022-08-05T09:13:51Z","external_id":{"pmid":["9007241"]},"day":"01","doi":"10.1242/dev.123.1.205","abstract":[{"lang":"eng","text":"In a screen for embryonic mutants in the zebrafish a large number of mutants were isolated with abnormal brain morphology, We describe here 26 mutants in 13 complementation groups that show abnormal development of large regions of the brain, Early neurogenesis is affected in white tail (wit), During segmentation stages, homozygous wit embryos display an irregularly formed neural keel, particularly in the hindbrain, Using a variety of molecular markers, a severe increase in the number of various early differentiating neurons can be demonstrated, In contrast, late differentiating neurons, radial glial cells and some nonneural cell types, such as the neural crest-derived melanoblasts, are much reduced, Somitogenesis appears delayed, In addition, very reduced numbers of melanophores are present posterior to the mid-trunk, The wit phenotype is reminiscent of neurogenic mutants in Drosophila, such as Notch or Delta, In mutant parachute (pac) embryos the general organization of the hindbrain is disturbed and many rounded cells accumulate loosely in the hindbrain and midbrain ventricles, Mutants in a group of 6 genes, snakehead(snk), natter (nat), otter (ott) fullbrain (ful) viper (vip) and white snake (wis) develop collapsed brain ventricles, before showing signs of general degeneration, atlantis (atl), big head (bid), wicked brain (win), scabland (sbd) and eisspalte (ele) mutants have different malformation of the brain folds, Some of them have transient phenotypes, and mutant individuals may grow up to adults."}]},{"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"1996-12-01T00:00:00Z","type":"journal_article","publist_id":"1913","publication_identifier":{"issn":["0950-1991"]},"language":[{"iso":"eng"}],"publication":"Development","month":"12","oa_version":"None","extern":"1","volume":123,"acknowledgement":"We thank E. Weinberg for the kind gift of myoD, zotx-2 and zash1b cDNA, I. Mikkola and S. Krauss for providing pax2/6 antibodies and shh cDNA, and V. Korzh for providing the pan-islet antibody. We are grateful to S. Wilson for help with the initial characterization of the mbl phenotype and many valuable comments on the manuscript. We would also like to thank Robert Geisler, Suresh Jesuthasan, Rolf Karlstrom, Stefan Schulte-Merker and Siegfried Roth for critical reading of the manuscript.","external_id":{"pmid":["9007240 "]},"date_updated":"2022-08-05T08:06:15Z","year":"1996","citation":{"apa":"Heisenberg, C.-P. J., Brand, M., Jiang, Y., Warga, R., Beuchle, D., Van Eeden, F., … Nüsslein Volhard, C. (1996). Genes involved in forebrain development in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.191 \">https://doi.org/10.1242/dev.123.1.191 </a>","ama":"Heisenberg C-PJ, Brand M, Jiang Y, et al. Genes involved in forebrain development in the zebrafish, Danio rerio. <i>Development</i>. 1996;123:191-203. doi:<a href=\"https://doi.org/10.1242/dev.123.1.191 \">10.1242/dev.123.1.191 </a>","chicago":"Heisenberg, Carl-Philipp J, Michael Brand, Yunjin Jiang, Rachel Warga, Dirk Beuchle, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Genes Involved in Forebrain Development in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.191 \">https://doi.org/10.1242/dev.123.1.191 </a>.","ieee":"C.-P. J. Heisenberg <i>et al.</i>, “Genes involved in forebrain development in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123. Company of Biologists, pp. 191–203, 1996.","mla":"Heisenberg, Carl-Philipp J., et al. “Genes Involved in Forebrain Development in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 191–203, doi:<a href=\"https://doi.org/10.1242/dev.123.1.191 \">10.1242/dev.123.1.191 </a>.","short":"C.-P.J. Heisenberg, M. Brand, Y. Jiang, R. Warga, D. Beuchle, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 191–203.","ista":"Heisenberg C-PJ, Brand M, Jiang Y, Warga R, Beuchle D, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 123, 191–203."},"abstract":[{"text":"We identified four zebrafish mutants with defects in forebrain induction and patterning during embryogenesis. The four mutants define three genes: masterblind (mbl), silverblick (slb), and knollnase (kas), In mbl embryos, the anterior forebrain acquires posterior forebrain characteristics: anterior structures such as the eyes, olfactory placodes and the telencephalon are missing, whereas the epiphysis located in the posterior forebrain is expanded, In slb embryos, the extension of the embryonic axis is initially delayed and eventually followed by a partial fusion of the eyes, Finally, in kas embryos, separation of the telencephalic primordia is incomplete and dorsal midline cells fail to form a differentiated roof plate, Analysis of the mutant phenotypes indicates that we have identified genes essential for the specification of the anterior forebrain (mbl), positioning of the eyes (slb) and differentiation of the roof plate (kas). In an appendix to this study we list mutants showing alterations in the size of the eyes and abnormal differentiation of the lenses.","lang":"eng"}],"doi":"10.1242/dev.123.1.191 ","day":"01","page":"191 - 203","quality_controlled":"1","article_type":"original","publisher":"Company of Biologists","author":[{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"first_name":"Rachel","last_name":"Warga","full_name":"Warga, Rachel"},{"last_name":"Beuchle","first_name":"Dirk","full_name":"Beuchle, Dirk"},{"full_name":"Van Eeden, Fredericus","last_name":"Van Eeden","first_name":"Fredericus"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"first_name":"Pascal","last_name":"Haffter","full_name":"Haffter, Pascal"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"full_name":"Kelsh, Robert","first_name":"Robert","last_name":"Kelsh"},{"last_name":"Mullins","first_name":"Mary","full_name":"Mullins, Mary"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"last_name":"Nüsslein Volhard","first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane"}],"pmid":1,"_id":"4203","scopus_import":"1","title":"Genes involved in forebrain development in the zebrafish, Danio rerio","intvolume":"       123","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:34Z"},{"publication_identifier":{"issn":["0950-1991"]},"publist_id":"1908","type":"journal_article","date_published":"1996-12-01T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","month":"12","publication":"Development","language":[{"iso":"eng"}],"day":"01","doi":"10.1242/dev.123.1.143","abstract":[{"text":"We have identified several genes that are required for various morphogenetic processes during gastrulation and tail formation, Two genes are required in the anterior region of the body axis: one eyed pinhead (oep) and dir ty nose (dns). oep mutant embryos are defective in prechordal plate formation and the specification of anterior and ventral structures of the central nervous system, In dns mutants, cells of the prechordal plate, such as the prospective hatching gland cells, fail to specify. Two genes are required for convergence and extension movements. In mutant trilobite embryos, extension movements on the dorsal side of the embryo are affected, whereas in the formerly described spadetail mutants, for which two new alleles have been isolated, convergent movements of ventrolateral cells to the dorsal side are blocked. Two genes are required for the development of the posterior end of the body axis, In pipetail mutants, the tailbud fails to move ventrally on the yolk sac after germ ring closure, and the tip of the tail fails to detach from the yolk tube. Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac.","lang":"eng"}],"citation":{"apa":"Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Brand, M., Van Eeden, F., … Nüsslein Volhard, C. (1996). Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.143\">https://doi.org/10.1242/dev.123.1.143</a>","ama":"Hammerschmidt M, Pelegri F, Mullins M, et al. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):143-151. doi:<a href=\"https://doi.org/10.1242/dev.123.1.143\">10.1242/dev.123.1.143</a>","chicago":"Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting Morphogenesis during Gastrulation and Tail Formation in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.143\">https://doi.org/10.1242/dev.123.1.143</a>.","ieee":"M. Hammerschmidt <i>et al.</i>, “Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 143–151, 1996.","mla":"Hammerschmidt, Matthias, et al. “Mutations Affecting Morphogenesis during Gastrulation and Tail Formation in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 143–51, doi:<a href=\"https://doi.org/10.1242/dev.123.1.143\">10.1242/dev.123.1.143</a>.","short":"M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 143–151.","ista":"Hammerschmidt M, Pelegri F, Mullins M, Kane D, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development. 123(1), 143–151."},"year":"1996","date_updated":"2022-08-05T06:59:42Z","external_id":{"pmid":["9007236"]},"acknowledgement":"M. H. and F. P. contributed equally to this work. We are very grateful to Dr Andrew McMahon, in whose laboratory much of the mutant analysis has been carried out. Additionally, we would like to thank Ed Sullivan for his help and advice during the setting-up of a fish facility in the McMahon laboratory. Dr Eric Weinberg generously supplied us with the myoD cDNA prior to publication. Published reagents were obtained from Drs Marie-Andrée Akimenko, Jean Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.","volume":123,"extern":"1","date_created":"2018-12-11T12:07:35Z","article_processing_charge":"No","publication_status":"published","intvolume":"       123","title":"Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio","scopus_import":"1","_id":"4208","pmid":1,"issue":"1","author":[{"full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt","first_name":"Matthias"},{"full_name":"Pelegri, Francisco","first_name":"Francisco","last_name":"Pelegri"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"first_name":"Michael","last_name":"Brand","full_name":"Brand, Michael"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"full_name":"Granato, Michael","last_name":"Granato","first_name":"Michael"},{"first_name":"Pascal","last_name":"Haffter","full_name":"Haffter, Pascal"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Jiang, Yunjin","last_name":"Jiang","first_name":"Yunjin"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Odenthal, Jörg","last_name":"Odenthal","first_name":"Jörg"},{"last_name":"Warga","first_name":"Rachel","full_name":"Warga, Rachel"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"publisher":"Company of Biologists","article_type":"original","quality_controlled":"1","page":"143 - 151"},{"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"1906","publication_identifier":{"issn":["0043-5546"]},"type":"journal_article","date_published":"1996-11-27T00:00:00Z","language":[{"iso":"eng"}],"month":"11","oa_version":"None","publication":"Development Genes and Evolution","extern":"1","volume":206,"abstract":[{"text":"Mutations causing a visible phenotype in the adult serve as valuable visible genetic markers in multicellular genetic model organisms such as Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations affecting early development of the zebrafish, we identified a number of mutations that are homozygous viable or semiviable. Here we describe viable mutations which produce visible phenotypes in the adult fish. These predominantly affect the fins and pigmentation, but also the eyes and body length of the adult. A number of dominant mutations caused visible phenotypes in the adult fish, Mutations in three genes, long fin, another long fin and wanda affected fin formation in the adult. Four mutations were found to cause a dominant reduction of the overall body length in the adult. The adult pigment pattern was found to be changed by dominant mutations in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations producing visible phenotypes in the homozygous adult, a group of mutations that failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish.","lang":"eng"}],"day":"27","doi":"10.1007/s004270050051","external_id":{"pmid":["24173565"]},"year":"1996","citation":{"mla":"Haffter, Pascal, et al. “Mutations Affecting Pigmentation and Shape of the Adult Zebrafish.” <i>Development Genes and Evolution</i>, vol. 206, no. 4, Springer, 1996, pp. 260–76, doi:<a href=\"https://doi.org/10.1007/s004270050051\">10.1007/s004270050051</a>.","short":"P. Haffter, J. Odenthal, M. Mullins, S. Lin, M. Farrell, E. Vogelsang, F. Haas, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, N. Hopkins, C. Nüsslein Volhard, Development Genes and Evolution 206 (1996) 260–276.","ista":"Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, Haas F, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Hopkins N, Nüsslein Volhard C. 1996. Mutations affecting pigmentation and shape of the adult zebrafish. Development Genes and Evolution. 206(4), 260–276.","apa":"Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E., … Nüsslein Volhard, C. (1996). Mutations affecting pigmentation and shape of the adult zebrafish. <i>Development Genes and Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s004270050051\">https://doi.org/10.1007/s004270050051</a>","ama":"Haffter P, Odenthal J, Mullins M, et al. Mutations affecting pigmentation and shape of the adult zebrafish. <i>Development Genes and Evolution</i>. 1996;206(4):260-276. doi:<a href=\"https://doi.org/10.1007/s004270050051\">10.1007/s004270050051</a>","chicago":"Haffter, Pascal, Jörg Odenthal, Mary Mullins, Shuo Lin, Michael Farrell, Elisabeth Vogelsang, Fabian Haas, et al. “Mutations Affecting Pigmentation and Shape of the Adult Zebrafish.” <i>Development Genes and Evolution</i>. Springer, 1996. <a href=\"https://doi.org/10.1007/s004270050051\">https://doi.org/10.1007/s004270050051</a>.","ieee":"P. Haffter <i>et al.</i>, “Mutations affecting pigmentation and shape of the adult zebrafish,” <i>Development Genes and Evolution</i>, vol. 206, no. 4. Springer, pp. 260–276, 1996."},"date_updated":"2022-08-04T14:45:21Z","article_type":"original","publisher":"Springer","quality_controlled":"1","page":"260 - 276","intvolume":"       206","title":"Mutations affecting pigmentation and shape of the adult zebrafish","article_processing_charge":"No","date_created":"2018-12-11T12:07:36Z","publication_status":"published","issue":"4","author":[{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"full_name":"Odenthal, Jörg","last_name":"Odenthal","first_name":"Jörg"},{"first_name":"Mary","last_name":"Mullins","full_name":"Mullins, Mary"},{"last_name":"Lin","first_name":"Shuo","full_name":"Lin, Shuo"},{"last_name":"Farrell","first_name":"Michael","full_name":"Farrell, Michael"},{"first_name":"Elisabeth","last_name":"Vogelsang","full_name":"Vogelsang, Elisabeth"},{"first_name":"Fabian","last_name":"Haas","full_name":"Haas, Fabian"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"last_name":"Furutani Seiki","first_name":"Makoto","full_name":"Furutani Seiki, Makoto"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"full_name":"Kelsh, Robert","first_name":"Robert","last_name":"Kelsh"},{"full_name":"Hopkins, Nancy","last_name":"Hopkins","first_name":"Nancy"},{"full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard","first_name":"Christiane"}],"scopus_import":"1","pmid":1,"_id":"4210"},{"publication":"Development","month":"12","oa_version":"None","language":[{"iso":"eng"}],"date_published":"1996-12-01T00:00:00Z","type":"journal_article","publist_id":"1907","publication_identifier":{"issn":["0950-1991"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","author":[{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"last_name":"Pelegri","first_name":"Francisco","full_name":"Pelegri, Francisco"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"first_name":"Donald","last_name":"Kane","full_name":"Kane, Donald"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"first_name":"Michael","last_name":"Brand","full_name":"Brand, Michael"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"full_name":"Haffter, Pascal","last_name":"Haffter","first_name":"Pascal"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"last_name":"Warga","first_name":"Rachel","full_name":"Warga, Rachel"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"issue":"1","pmid":1,"_id":"4211","scopus_import":"1","title":"Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo","intvolume":"       123","publication_status":"published","date_created":"2018-12-11T12:07:36Z","article_processing_charge":"No","page":"95 - 102","quality_controlled":"1","article_type":"original","publisher":"Company of Biologists","external_id":{"pmid":["9007232"]},"date_updated":"2022-08-04T15:10:34Z","year":"1996","citation":{"apa":"Hammerschmidt, M., Pelegri, F., Mullins, M., Kane, D., Van Eeden, F., Granato, M., … Nüsslein Volhard, C. (1996). Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.95\">https://doi.org/10.1242/dev.123.1.95</a>","ama":"Hammerschmidt M, Pelegri F, Mullins M, et al. Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. <i>Development</i>. 1996;123(1):95-102. doi:<a href=\"https://doi.org/10.1242/dev.123.1.95\">10.1242/dev.123.1.95</a>","chicago":"Hammerschmidt, Matthias, Francisco Pelegri, Mary Mullins, Donald Kane, Fredericus Van Eeden, Michael Granato, Michael Brand, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.95\">https://doi.org/10.1242/dev.123.1.95</a>.","ieee":"M. Hammerschmidt <i>et al.</i>, “Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 95–102, 1996.","short":"M. Hammerschmidt, F. Pelegri, M. Mullins, D. Kane, F. Van Eeden, M. Granato, M. Brand, M. Furutani Seiki, P. Haffter, C.-P.J. Heisenberg, Y. Jiang, R. Kelsh, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 95–102.","mla":"Hammerschmidt, Matthias, et al. “Dino and Mercedes, Two Genes Regulating Dorsal Development in the Zebrafish Embryo.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 95–102, doi:<a href=\"https://doi.org/10.1242/dev.123.1.95\">10.1242/dev.123.1.95</a>.","ista":"Hammerschmidt M, Pelegri F, Mullins M, Kane D, Van Eeden F, Granato M, Brand M, Furutani Seiki M, Haffter P, Heisenberg C-PJ, Jiang Y, Kelsh R, Odenthal J, Warga R, Nüsslein Volhard C. 1996. Dino and Mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 123(1), 95–102."},"abstract":[{"lang":"eng","text":"We describe two genes, dino and mercedes, which are required for the organization of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the expense of the head and the anterior region of the trunk, The altered expression patterns of various marker genes reveal that, with the exception of the dorsal most marginal zone, all regions of the early dine mutant embryo acquire more ventral fates, These alterations are already apparent before the onset of gastrulation, mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes. The phenotypes suggests that dine and mercedes are required for the establishment of dorsal fates in both the marginal and the animal zone of the early gastrula embryo, Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo."}],"doi":"10.1242/dev.123.1.95","day":"01","extern":"1","volume":123,"acknowledgement":"We are very grateful to Dr Andrew McMahon in whose laboratory much of the mutant analysis has been carried out. Additionally, we would like to thank Ed Sullivan for his help and advice during the setting up of a fish facility in the McMahon laboratory. Drs Eric Weinberg and Leonard Zon generously supplied us with reagents prior to publication. Published reagents were obtained from Drs Jon Graff, Jean-Stéphane Joly, Stefan Krauss and Stefan Schulte-Merker.\r\nDrs Mary Dickinson, Andrew McMahon, Siegfried Roth and Stefan Schulte-Merker read earlier versions of the Manuscript. "},{"intvolume":"       123","title":"The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio","date_created":"2018-12-11T12:07:37Z","article_processing_charge":"No","publication_status":"published","issue":"1","author":[{"full_name":"Haffter, Pascal","last_name":"Haffter","first_name":"Pascal"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"full_name":"Mullins, Mary","last_name":"Mullins","first_name":"Mary"},{"full_name":"Hammerschmidt, Matthias","first_name":"Matthias","last_name":"Hammerschmidt"},{"full_name":"Kane, Donald","last_name":"Kane","first_name":"Donald"},{"first_name":"Jörg","last_name":"Odenthal","full_name":"Odenthal, Jörg"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kelsh, Robert","first_name":"Robert","last_name":"Kelsh"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"first_name":"Elisabeth","last_name":"Vogelsang","full_name":"Vogelsang, Elisabeth"},{"first_name":"Dirk","last_name":"Beuchle","full_name":"Beuchle, Dirk"},{"last_name":"Schach","first_name":"Ursula","full_name":"Schach, Ursula"},{"last_name":"Fabian","first_name":"Cosima","full_name":"Fabian, Cosima"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"scopus_import":"1","_id":"4212","pmid":1,"article_type":"original","publisher":"Company of Biologists","quality_controlled":"1","page":"1 - 36","abstract":[{"lang":"eng","text":"In a large-scale screen, we isolated mutants displaying a specific visible phenotype in embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with ethylnitrosourea (ENU) and F-2 families of single pair matings between sibling F-l fish, heterozygous for a mutagenized genome, were raised. Egg lays were obtained from several crosses between F-2 siblings, resulting in scoring of 3857 mutagenized genomes. F-3 progeny were scored at the second, third and sixth day of development, using a stereomicroscope. In a subsequent screen, fixed embryos were analyzed for correct retinotectal projection. A total of 4264 mutants were identified. Two thirds of the mutants displaying rather general abnormalities were eventually discarded. We kept and characterized 1163 mutants. In complementation crosses performed between mutants with similar phenotypes, 894 mutants have been assigned to 372 genes. The average allele frequency is 2.4. We identified genes involved in early development, notochord, brain, spinal cord, somites, muscles, heart, circulation, blood, skin, fin, eye, otic vesicle, jaw and branchial arches, pigment pattern, pigment formation, gut, liver, motility and touch response. Our collection contains alleles of almost all previously described zebrafish mutants. From the allele frequencies and other considerations we estimate that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of our screen. Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish."}],"day":"01","doi":"10.1242/dev.123.1.1 ","external_id":{"pmid":["9007226 "]},"year":"1996","citation":{"chicago":"Haffter, Pascal, Michael Granato, Michael Brand, Mary Mullins, Matthias Hammerschmidt, Donald Kane, Jörg Odenthal, et al. “The Identification of Genes with Unique and Essential Functions in the Development of the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.1 \">https://doi.org/10.1242/dev.123.1.1 </a>.","ieee":"P. Haffter <i>et al.</i>, “The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 1–36, 1996.","ama":"Haffter P, Granato M, Brand M, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):1-36. doi:<a href=\"https://doi.org/10.1242/dev.123.1.1 \">10.1242/dev.123.1.1 </a>","apa":"Haffter, P., Granato, M., Brand, M., Mullins, M., Hammerschmidt, M., Kane, D., … Nüsslein Volhard, C. (1996). The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.1 \">https://doi.org/10.1242/dev.123.1.1 </a>","ista":"Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, Odenthal J, Van Eeden F, Jiang Y, Heisenberg C-PJ, Kelsh R, Furutani Seiki M, Vogelsang E, Beuchle D, Schach U, Fabian C, Nüsslein Volhard C. 1996. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development. 123(1), 1–36.","mla":"Haffter, Pascal, et al. “The Identification of Genes with Unique and Essential Functions in the Development of the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 1–36, doi:<a href=\"https://doi.org/10.1242/dev.123.1.1 \">10.1242/dev.123.1.1 </a>.","short":"P. Haffter, M. Granato, M. Brand, M. Mullins, M. Hammerschmidt, D. Kane, J. Odenthal, F. Van Eeden, Y. Jiang, C.-P.J. Heisenberg, R. Kelsh, M. Furutani Seiki, E. Vogelsang, D. Beuchle, U. Schach, C. Fabian, C. Nüsslein Volhard, Development 123 (1996) 1–36."},"date_updated":"2022-08-04T14:41:37Z","extern":"1","volume":123,"acknowledgement":"This work was a collaborative effort in which a large number of people participated during all or part of the three years of raising the families, screening and evaluation of the mutants. We thank Rachel Warga, Tatjana Piotrowski, Francisco Pelegri, Karin Rossnagel and Hans-Martin Maischein for collaboration at the beginning and the end of the screening and evaluation periods respectively; Hans-Georg Frohnhöfer for fish health care and for establishing the Tübingen zebrafish stockcenter; and Wolfgang Driever, Marc Fishman and collaborators, for sharing unpublished results. We enjoyed the visits of Alison Brownlie, Jau-Nian Chen, Nancy Hopkins, Corinne Houart, Shuo Lin, David Ransom, Thomas Schilling, Tanya Whitfield and Catherine Willet, who participated in the analysis of individual mutant classes. We also want to thank many undergraduate students from the Tübingen University for conscientious and efficient help in the maintenance and identification of fish, and Torsten Trowe, Rolf Karlstrom, Barbara Grunwald and Friedrich Bonhoeffer for pleasant and interesting conversations and collaborations. We thank the staff of our workshop for patience, \r\n Inventiveness and a very large number of fish containers. We thank Herwig Baier, Robert Geisler, Darren Gilmour,\r\nNancy Hopkins, Suresh Jesuthasan, Gerd Jürgens, Francisco Pelegri, Siegfried Roth, Stefan Schulte-Merker, Ralf Sommer, Daniel St Johnston and Tanya Whitfield, for many helpful suggestions on the manuscript; Robert Geisler for invaluable help with computers, cameras and colour printers, and the Tübingen fly group for interest, endless patience and support.","month":"12","oa_version":"None","publication":"Development","language":[{"iso":"eng"}],"publist_id":"1905","publication_identifier":{"issn":["0950-1991"]},"type":"journal_article","date_published":"1996-12-01T00:00:00Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public"},{"language":[{"iso":"eng"}],"oa_version":"None","month":"12","publication":"Development","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1903","date_published":"1996-12-01T00:00:00Z","type":"journal_article","publisher":"Company of Biologists","article_type":"original","page":"229 - 239","quality_controlled":"1","publication_status":"published","date_created":"2018-12-11T12:07:37Z","article_processing_charge":"No","title":"Neural degeneration mutants in the zebrafish, Danio rerio","intvolume":"       123","pmid":1,"_id":"4213","scopus_import":"1","author":[{"first_name":"Makoto","last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"full_name":"Brand, Michael","last_name":"Brand","first_name":"Michael"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Houart","first_name":"Corinne","full_name":"Houart, Corinne"},{"full_name":"Beuchle, Dirk","last_name":"Beuchle","first_name":"Dirk"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"full_name":"Granato, Michael","last_name":"Granato","first_name":"Michael"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt","first_name":"Matthias"},{"first_name":"Donald","last_name":"Kane","full_name":"Kane, Donald"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Mullins, Mary","last_name":"Mullins","first_name":"Mary"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"issue":"1","volume":123,"acknowledgement":"We are grateful to Rachel Warga, Tatijana Piotrowski, Francisco Pelegri and Tomas Schilling for sharing unpublished results. We thank Heinz Schwarz for histological sections and Eric Weinberg, Monte Westerfield, Stephen Wilson and Hitoshi Okamoto for in situprobes. We also thank Nancy Hopkins, Francisco Pelegri and Stefan Schulte-Merker for helpful suggestions on the manuscript, and Raymond Lamos for technical support.","extern":"1","doi":"10.1242/dev.123.1.229 ","day":"01","abstract":[{"lang":"eng","text":"Forty zebrafish mutants with localized or general neural degeneration are described. The onset and duration of degeneration and the distribution of ectopically dying cells are specific characteristics of each mutant, Mutants are classified into four groups by these parameters. Class I: late focal neural degeneration mutants, These 18 mutants have restricted cell death mainly in the tectum and the dorsal hindbrain after 36 hours, The degeneration does not spread and disappears at later stages of development. Class LI: early focal neural degeneration mutants. Ten mutants in this class exhibit transient restricted degeneration affecting mainly the diencephalon, the hindbrain and the spinal cord at 20 hours, The midbrain is less affected. The degeneration shifts to the dorsal diencephalon and the tectum at 36 hours. Class III: late spreading neural degeneration mutants. The 8 mutants in this class display a degeneration that is first seen in the tectum and subsequently spreads throughout the nervous system from 36 hours on. Class IV: early general neural degeneration mutants, This class of four mutants already shows overall cell degeneration in the nervous system at the 15-somite stage. Three of the class I mutants show a change in the pattern of gene expression in the anlage of a brain structure prior to the onset of degeneration. These results suggest that focal cell death may be a useful clue for the detection of early patterning defects of the vertebrate nervous system in regions devoid of visible landmarks."}],"date_updated":"2022-08-04T14:02:39Z","citation":{"ama":"Furutani Seiki M, Jiang Y, Brand M, et al. Neural degeneration mutants in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):229-239. doi:<a href=\"https://doi.org/10.1242/dev.123.1.229 \">10.1242/dev.123.1.229 </a>","apa":"Furutani Seiki, M., Jiang, Y., Brand, M., Heisenberg, C.-P. J., Houart, C., Beuchle, D., … Nüsslein Volhard, C. (1996). Neural degeneration mutants in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.229 \">https://doi.org/10.1242/dev.123.1.229 </a>","chicago":"Furutani Seiki, Makoto, Yunjin Jiang, Michael Brand, Carl-Philipp J Heisenberg, Corinne Houart, Dirk Beuchle, Fredericus Van Eeden, et al. “Neural Degeneration Mutants in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.229 \">https://doi.org/10.1242/dev.123.1.229 </a>.","ieee":"M. Furutani Seiki <i>et al.</i>, “Neural degeneration mutants in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 229–239, 1996.","short":"M. Furutani Seiki, Y. Jiang, M. Brand, C.-P.J. Heisenberg, C. Houart, D. Beuchle, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 229–239.","mla":"Furutani Seiki, Makoto, et al. “Neural Degeneration Mutants in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 229–39, doi:<a href=\"https://doi.org/10.1242/dev.123.1.229 \">10.1242/dev.123.1.229 </a>.","ista":"Furutani Seiki M, Jiang Y, Brand M, Heisenberg C-PJ, Houart C, Beuchle D, Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Neural degeneration mutants in the zebrafish, Danio rerio. Development. 123(1), 229–239."},"year":"1996","external_id":{"pmid":["9007243 "]}},{"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_published":"1996-12-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1904","language":[{"iso":"eng"}],"publication":"Development","oa_version":"None","month":"12","volume":123,"acknowledgement":"We would like to thank C. Kimmel, J. Eisen and M. Westerfield for providing the nic and fub mutant strains used for complementation and for the znp1 antibody. In addition we thank Tanja Whitfield and Suresh Jesuthesan for critical reading of the manuscript. This work was supported by a DFG postdoctoral fellowship Gr 1370/1-1 to M.G.","extern":"1","date_updated":"2022-08-04T14:20:50Z","year":"1996","citation":{"ista":"Granato M, Van Eeden F, Schach U, Trowe T, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development. 123, 399–413.","short":"M. Granato, F. Van Eeden, U. Schach, T. Trowe, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 399–413.","mla":"Granato, Michael, et al. “Genes Controlling and Mediating Locomotion Behavior of the Zebrafish Embryo and Larva.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 399–413, doi:<a href=\"https://doi.org/10.1242/dev.123.1.399\">10.1242/dev.123.1.399</a>.","chicago":"Granato, Michael, Fredericus Van Eeden, Ursula Schach, Torsten Trowe, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, et al. “Genes Controlling and Mediating Locomotion Behavior of the Zebrafish Embryo and Larva.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.399\">https://doi.org/10.1242/dev.123.1.399</a>.","ieee":"M. Granato <i>et al.</i>, “Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva,” <i>Development</i>, vol. 123. Company of Biologists, pp. 399–413, 1996.","ama":"Granato M, Van Eeden F, Schach U, et al. Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. <i>Development</i>. 1996;123:399-413. doi:<a href=\"https://doi.org/10.1242/dev.123.1.399\">10.1242/dev.123.1.399</a>","apa":"Granato, M., Van Eeden, F., Schach, U., Trowe, T., Brand, M., Furutani Seiki, M., … Nüsslein Volhard, C. (1996). Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.399\">https://doi.org/10.1242/dev.123.1.399</a>"},"external_id":{"pmid":["9007258"]},"doi":"10.1242/dev.123.1.399","day":"01","abstract":[{"text":"Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion, Two embryonic structures accomplish this behavior: the central nervous system (CNS) and skeletal muscles. To identify genes that are functionally involved in mediating and controlling different patterns of embryonic and larval motility, we included a simple touch response test in our zebrafish large-scale genetic screen, In total we identified 166 mutants with specific defects in embryonic motility. These mutants fall into 14 phenotypically distinct groups comprising at least 48 genes, Here we describe the various phenotypic groups including mutants with no or reduced motility, mechanosensory defective mutants, 'spastic' mutants, circling mutants and motor circuit defective mutants, In 63 mutants, defining 18 genes, striation of semitic muscles is reduced, Phenotypic analysis provides evidence that these 18 genes have distinct and consecutive functions during semitic muscle development. The genes sloth (slo) and frozen (fro) already act during myoblast differentiation, while 13 genes appear to function later, in the formation of myofibers and the organization of sarcomeres, Mutations in four other genes result in muscle-specific degeneration, 103 mutations, defining at least 30 genes, cause no obvious defects in muscle formation and may instead affect neuronal development. Analysis of the behavioral defects suggests that these genes participate in the diverse locomotion patterns observed, such as touch response, rhythmic tail movements, equilibrium control, or that they simply confer general motility to the animal, In some of these mutants specific defects in the developing nervous system are detected, Mutations in two genes, nevermind (nev) and macho (mao), affect axonal projection in the optic tectum, whereas axon formation and elongation of motorneurons are disrupted by mutations in the diwanka (diw) and the unplugged (unp) genes.","lang":"eng"}],"page":"399 - 413","quality_controlled":"1","publisher":"Company of Biologists","article_type":"original","_id":"4214","pmid":1,"scopus_import":"1","author":[{"last_name":"Granato","first_name":"Michael","full_name":"Granato, Michael"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"full_name":"Schach, Ursula","last_name":"Schach","first_name":"Ursula"},{"first_name":"Torsten","last_name":"Trowe","full_name":"Trowe, Torsten"},{"full_name":"Brand, Michael","first_name":"Michael","last_name":"Brand"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"full_name":"Haffter, Pascal","first_name":"Pascal","last_name":"Haffter"},{"full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt","first_name":"Matthias"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Jiang, Yunjin","last_name":"Jiang","first_name":"Yunjin"},{"first_name":"Donald","last_name":"Kane","full_name":"Kane, Donald"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"last_name":"Odenthal","first_name":"Jörg","full_name":"Odenthal, Jörg"},{"full_name":"Nüsslein Volhard, Christiane","first_name":"Christiane","last_name":"Nüsslein Volhard"}],"publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:38Z","title":"Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva","intvolume":"       123"},{"extern":"1","volume":123,"acknowledgement":"We thank Chris Simpson and Colleen Boggs for excellent technical help. We thank Mark C. Fishman for the advice and providing fish for complementation; Bernadette Fouquet, Kerri S. Warren and Brant M. Weinstein for critically reading the manuscript. JNC is supported in part by NIH grant RO1-HL49579 to Mark C. Fishman.","external_id":{"pmid":["9007249"]},"date_updated":"2022-08-04T13:11:56Z","citation":{"short":"J. Chen, P. Haffter, J. Odenthal, E. Vogelsang, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, C. Nüsslein Volhard, Development 123 (1996) 293–302.","mla":"Chen, Jaunian, et al. “Mutations Affecting the Cardiovascular System and Other Internal Organs in Zebrafish.” <i>Development</i>, vol. 123, Company of Biologists, 1996, pp. 293–302, doi:<a href=\"https://doi.org/10.1242/dev.123.1.293\">10.1242/dev.123.1.293</a>.","ista":"Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Nüsslein Volhard C. 1996. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development. 123, 293–302.","ama":"Chen J, Haffter P, Odenthal J, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. <i>Development</i>. 1996;123:293-302. doi:<a href=\"https://doi.org/10.1242/dev.123.1.293\">10.1242/dev.123.1.293</a>","apa":"Chen, J., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., Van Eeden, F., … Nüsslein Volhard, C. (1996). Mutations affecting the cardiovascular system and other internal organs in zebrafish. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.293\">https://doi.org/10.1242/dev.123.1.293</a>","ieee":"J. Chen <i>et al.</i>, “Mutations affecting the cardiovascular system and other internal organs in zebrafish,” <i>Development</i>, vol. 123. Company of Biologists, pp. 293–302, 1996.","chicago":"Chen, Jaunian, Pascal Haffter, Jörg Odenthal, Elisabeth Vogelsang, Michael Brand, Fredericus Van Eeden, Makoto Furutani Seiki, et al. “Mutations Affecting the Cardiovascular System and Other Internal Organs in Zebrafish.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.293\">https://doi.org/10.1242/dev.123.1.293</a>."},"year":"1996","abstract":[{"text":"In a screen for early developmental mutants of the zebrafish, we have identified mutations specifically affecting the internal organs, We identified 53 mutations affecting the cardiovascular system, Nine of them affect specific landmarks of heart morphogenesis. Mutations in four genes cause a failure in the fusion of the bilateral heart primordia, resulting in cardia bifida. In lonely atrium, no heart venticle is visible and the atrium is directly fused to the outflow tract. In the overlooped mutant, the relative position of the two heart chambers is distorted, The heart is enormously enlarged in the santa mutant, In two mutants, scotch tape and superglue, the cardiac jelly between the two layers of the heart is significantly reduced, We also identified a number of mutations affecting the function of the heart, The mutations affecting heart function can be subdivided into two groups, one affecting heart contraction and another affecting the rhythm of the heart beat. Among the contractility group of mutants are 5 with no heart beat at all and 15 with a reduced heart beat of one or both chambers, 6 mutations are in the rhythmicity group and specifically affect the beating pattern of the heart, Mutations in two genes, bypass and kurzschluss, cause specific defects in the circulatory system, In addition to the heart mutants, we identified 23 mutations affecting the integrity of the liver, the intestine or the kidney, In this report, we demonstrate that it is feasible to screen for genes specific for the patterning or function of certain internal organs in the zebrafish, The mutations presented here could serve as an entrypoint to the establishment of a genetic hierarchy underlying organogenesis.","lang":"eng"}],"doi":"10.1242/dev.123.1.293","day":"01","page":"293 - 302","quality_controlled":"1","article_type":"original","publisher":"Company of Biologists","author":[{"first_name":"Jaunian","last_name":"Chen","full_name":"Chen, Jaunian"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"first_name":"Jörg","last_name":"Odenthal","full_name":"Odenthal, Jörg"},{"full_name":"Vogelsang, Elisabeth","last_name":"Vogelsang","first_name":"Elisabeth"},{"last_name":"Brand","first_name":"Michael","full_name":"Brand, Michael"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"last_name":"Granato","first_name":"Michael","full_name":"Granato, Michael"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Jiang, Yunjin","last_name":"Jiang","first_name":"Yunjin"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"first_name":"Robert","last_name":"Kelsh","full_name":"Kelsh, Robert"},{"full_name":"Mullins, Mary","last_name":"Mullins","first_name":"Mary"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"pmid":1,"_id":"4215","scopus_import":"1","title":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","intvolume":"       123","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:07:38Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/293/39344/Mutations-affecting-the-cardiovascular-system-and"}],"date_published":"1996-12-01T00:00:00Z","type":"journal_article","oa":1,"publist_id":"1902","publication_identifier":{"issn":["0950-1991"]},"language":[{"iso":"eng"}],"publication":"Development","month":"12","oa_version":"Published Version"},{"quality_controlled":"1","page":"129 - 142","publisher":"Company of Biologists","article_type":"original","scopus_import":"1","_id":"4216","pmid":1,"issue":"1","author":[{"first_name":"Michael","last_name":"Brand","full_name":"Brand, Michael"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Warga, Rachel","first_name":"Rachel","last_name":"Warga"},{"full_name":"Pelegri, Francisco","first_name":"Francisco","last_name":"Pelegri"},{"full_name":"Karlstrom, Rolf","last_name":"Karlstrom","first_name":"Rolf"},{"first_name":"Dirk","last_name":"Beuchle","full_name":"Beuchle, Dirk"},{"full_name":"Picker, Alexander","first_name":"Alexander","last_name":"Picker"},{"full_name":"Jiang, Yunjin","first_name":"Yunjin","last_name":"Jiang"},{"first_name":"Makoto","last_name":"Furutani Seiki","full_name":"Furutani Seiki, Makoto"},{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"full_name":"Granato, Michael","last_name":"Granato","first_name":"Michael"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"full_name":"Kane, Donald","last_name":"Kane","first_name":"Donald"},{"first_name":"Robert","last_name":"Kelsh","full_name":"Kelsh, Robert"},{"first_name":"Mary","last_name":"Mullins","full_name":"Mullins, Mary"},{"first_name":"Jörg","last_name":"Odenthal","full_name":"Odenthal, Jörg"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"article_processing_charge":"No","date_created":"2018-12-11T12:07:38Z","publication_status":"published","intvolume":"       123","title":"Mutations affecting development of the midline and general body shape during zebrafish embryogenesis","acknowledgement":"We would like to thank our colleagues in the zebrafish community for generously sharing antibodies and probes, in particular PhilIngham, Stefan Krauss and Vladimir Korzh, as well as Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M. B. thanks Steve Wilson for comments on the manuscript, his colleagues at the institute for numerous discussions, Inge Zimmermann for patient sectioning, and Silke Hein for help during the final\r\nstages of this work. M. B. was supported by a Helmholtz stipend of the BMFT.","volume":123,"extern":"1","year":"1996","citation":{"ieee":"M. Brand <i>et al.</i>, “Mutations affecting development of the midline and general body shape during zebrafish embryogenesis,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 129–142, 1996.","chicago":"Brand, Michael, Carl-Philipp J Heisenberg, Rachel Warga, Francisco Pelegri, Rolf Karlstrom, Dirk Beuchle, Alexander Picker, et al. “Mutations Affecting Development of the Midline and General Body Shape during Zebrafish Embryogenesis.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.129 \">https://doi.org/10.1242/dev.123.1.129 </a>.","apa":"Brand, M., Heisenberg, C.-P. J., Warga, R., Pelegri, F., Karlstrom, R., Beuchle, D., … Nüsslein Volhard, C. (1996). Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.129 \">https://doi.org/10.1242/dev.123.1.129 </a>","ama":"Brand M, Heisenberg C-PJ, Warga R, et al. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. <i>Development</i>. 1996;123(1):129-142. doi:<a href=\"https://doi.org/10.1242/dev.123.1.129 \">10.1242/dev.123.1.129 </a>","ista":"Brand M, Heisenberg C-PJ, Warga R, Pelegri F, Karlstrom R, Beuchle D, Picker A, Jiang Y, Furutani Seiki M, Van Eeden F, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Nüsslein Volhard C. 1996. Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development. 123(1), 129–142.","short":"M. Brand, C.-P.J. Heisenberg, R. Warga, F. Pelegri, R. Karlstrom, D. Beuchle, A. Picker, Y. Jiang, M. Furutani Seiki, F. Van Eeden, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, C. Nüsslein Volhard, Development 123 (1996) 129–142.","mla":"Brand, Michael, et al. “Mutations Affecting Development of the Midline and General Body Shape during Zebrafish Embryogenesis.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 129–42, doi:<a href=\"https://doi.org/10.1242/dev.123.1.129 \">10.1242/dev.123.1.129 </a>."},"date_updated":"2022-08-04T12:55:13Z","external_id":{"pmid":["9007235 "]},"day":"01","doi":"10.1242/dev.123.1.129 ","abstract":[{"lang":"eng","text":"Tissues of the dorsal midline of vertebrate embryos, such as notochord and floor plate, have been implicated in inductive interactions that pattern the neural tube and somites. In our screen for embryonic visible mutations in the zebrafish we found 113 mutations in more than 27 genes with altered body shape, often with additional defects in CNS development. We concentrated on a subgroup of mutations in ten genes (the midline-group) that cause defective development of the floor plate. By using floor plate markers, such as the signaling molecule sonic hedgehog, we show that the schmalspur (sur) gene is needed for early floor plate development, similar to one-eyed-pinhead (oep) and the previously described cyclops (eye) gene. In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In the underlying mesendodermal tissue of the head, sur is needed only for development of the posterior prechordal plate, whereas oep and eye are required for both anterior and posterior prechordal plate development. Our analysis of sur mutants suggests that defects within the posterior prechordal plate may cause aberrant development of ventral CNS structures in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour, schmalkars and monorail embryos; these mutants often show additional defects in tissues that are known to depend on signals from notochord and floor plate, For example, sur, con, and yot mutants show reduction of motor neurons; median deletions of brain tissue are seen in sur, con and yot embryos; and eye, con, yet, igu and dtr mutants often show no or abnormal formation of the optic chiasm. We also find fusions of the ventral neurocranium for all midline mutants tested, which may reveal a hitherto unrecognized function of the midline in influencing differentiation of neural crest cells at their destination. As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues."}],"language":[{"iso":"eng"}],"publication":"Development","oa_version":"Published Version","month":"12","main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/129/39318/Mutations-affecting-development-of-the-midline-and"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","date_published":"1996-12-01T00:00:00Z","publication_identifier":{"issn":["0950-1991"]},"publist_id":"1900","oa":1},{"extern":"1","acknowledgement":"We would like to thank our colleagues in the zebrafish community for generously sharing antibodies and probes, in particular Terje Johannsen, Vladimir Korzh, Stefan Krauss and Ingvild Mikkola, as well as Christine Dreyer, Nigel Holder, Tom Jessel, Trevor Jowett, Anders Molven, Eric Weinberg and Monte Westerfield. M.B would like to thank his colleagues for numerous discussions, and Francisco Pelegri, Suresh Jesuthasan and Luis Puelles for comments on the\r\nmanuscipt. Thanks also to Peter Andermann and Eric Weinberg, who helped in the analysis of Zash expression, and especially to Corinne Houart, for her lovely in situ protocol and many discussions. Silke Hein helped greatly in final stages of this work. M.B. was supported by a Helmholtz stipend of the BMFT.","volume":123,"external_id":{"pmid":["9007239 "]},"year":"1996","citation":{"ista":"Brand M, Heisenberg C-PJ, Jiang Y, Beuchle D, Lun K, Furutani Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D, Kelsh R, Mullins M, Odenthal J, Van Eeden F, Nüsslein Volhard C. 1996. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development. 123(1), 179–190.","short":"M. Brand, C.-P.J. Heisenberg, Y. Jiang, D. Beuchle, K. Lun, M. Furutani Seiki, M. Granato, P. Haffter, M. Hammerschmidt, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, F. Van Eeden, C. Nüsslein Volhard, Development 123 (1996) 179–190.","mla":"Brand, Michael, et al. “Mutations in Zebrafish Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 179–90, doi:<a href=\"https://doi.org/10.1242/dev.123.1.179 \">10.1242/dev.123.1.179 </a>.","ieee":"M. Brand <i>et al.</i>, “Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 179–190, 1996.","chicago":"Brand, Michael, Carl-Philipp J Heisenberg, Yunjin Jiang, Dirk Beuchle, Klaus Lun, Makoto Furutani Seiki, Michael Granato, et al. “Mutations in Zebrafish Genes Affecting the Formation of the Boundary between Midbrain and Hindbrain.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.179 \">https://doi.org/10.1242/dev.123.1.179 </a>.","apa":"Brand, M., Heisenberg, C.-P. J., Jiang, Y., Beuchle, D., Lun, K., Furutani Seiki, M., … Nüsslein Volhard, C. (1996). Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.179 \">https://doi.org/10.1242/dev.123.1.179 </a>","ama":"Brand M, Heisenberg C-PJ, Jiang Y, et al. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. <i>Development</i>. 1996;123(1):179-190. doi:<a href=\"https://doi.org/10.1242/dev.123.1.179 \">10.1242/dev.123.1.179 </a>"},"date_updated":"2022-08-04T11:45:04Z","abstract":[{"text":"Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace), noi mutant embryos lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that the MHB region and the dorsal and ventral midbrain are absent or abnormal, but that the rostral hindbrain is unaffected with the exception of the cerebellum, Using markers that are expressed during its formation (eng, wnt1 and pax-b), we find that the MHB region is already misspecified in noi mutant embryos during late gastrulation. The tectum is initially present and later degenerates, The defect in ace mutant embryos is more restricted: MHB and cerebellum are absent, but a tectum is formed, Molecular organisation of the tectum and tegmentum is disturbed, however, since eng, wntl and pax-b marker gene expression is not maintained, We propose that noi and ace are required for development of the MHB region and of the adjacent mid- and hindbrain, which are thought to be patterned by the MHB region, Presence of pax-b RNA, and absence of pax-b protein, together with the observation of genetic linkage and the occurrence of a point mutation, show that noi mutations are located in the pax-b gene, pax-b is a vertebrate orthologue of the Drosophila gene paired, which is involved in a pathway of cellular interactions at the posterior compartment boundary in Drosophila, Our results confirm and extend a previous report, and show that at least one member of this conserved signalling pathway is required for formation of the boundary between midbrain and hindbrain in the zebrafish.","lang":"eng"}],"day":"01","doi":"10.1242/dev.123.1.179 ","quality_controlled":"1","page":"179 - 190","article_type":"original","publisher":"Company of Biologists","issue":"1","author":[{"last_name":"Brand","first_name":"Michael","full_name":"Brand, Michael"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"},{"first_name":"Yunjin","last_name":"Jiang","full_name":"Jiang, Yunjin"},{"first_name":"Dirk","last_name":"Beuchle","full_name":"Beuchle, Dirk"},{"full_name":"Lun, Klaus","first_name":"Klaus","last_name":"Lun"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"full_name":"Granato, Michael","first_name":"Michael","last_name":"Granato"},{"last_name":"Haffter","first_name":"Pascal","full_name":"Haffter, Pascal"},{"last_name":"Hammerschmidt","first_name":"Matthias","full_name":"Hammerschmidt, Matthias"},{"full_name":"Kane, Donald","first_name":"Donald","last_name":"Kane"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"first_name":"Mary","last_name":"Mullins","full_name":"Mullins, Mary"},{"first_name":"Jörg","last_name":"Odenthal","full_name":"Odenthal, Jörg"},{"last_name":"Van Eeden","first_name":"Fredericus","full_name":"Van Eeden, Fredericus"},{"last_name":"Nüsslein Volhard","first_name":"Christiane","full_name":"Nüsslein Volhard, Christiane"}],"scopus_import":"1","_id":"4219","pmid":1,"intvolume":"       123","title":"Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain","date_created":"2018-12-11T12:07:40Z","article_processing_charge":"No","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","main_file_link":[{"url":"https://journals.biologists.com/dev/article/123/1/179/39324/Mutations-in-zebrafish-genes-affecting-the","open_access":"1"}],"type":"journal_article","date_published":"1996-12-01T00:00:00Z","publist_id":"1899","oa":1,"publication_identifier":{"issn":["0950-1991"]},"language":[{"iso":"eng"}],"publication":"Development","month":"12","oa_version":"Published Version"},{"page":"255 - 262","quality_controlled":"1","article_type":"original","publisher":"Company of Biologists","author":[{"full_name":"Van Eeden, Fredericus","first_name":"Fredericus","last_name":"Van Eeden"},{"full_name":"Granato, Michael","last_name":"Granato","first_name":"Michael"},{"full_name":"Schach, Ursula","last_name":"Schach","first_name":"Ursula"},{"full_name":"Brand, Michael","last_name":"Brand","first_name":"Michael"},{"full_name":"Furutani Seiki, Makoto","last_name":"Furutani Seiki","first_name":"Makoto"},{"first_name":"Pascal","last_name":"Haffter","full_name":"Haffter, Pascal"},{"full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt","first_name":"Matthias"},{"last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jiang","first_name":"Yunjin","full_name":"Jiang, Yunjin"},{"first_name":"Donald","last_name":"Kane","full_name":"Kane, Donald"},{"full_name":"Kelsh, Robert","last_name":"Kelsh","first_name":"Robert"},{"first_name":"Mary","last_name":"Mullins","full_name":"Mullins, Mary"},{"full_name":"Odenthal, Jörg","first_name":"Jörg","last_name":"Odenthal"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"full_name":"Nüsslein Volhard, Christiane","last_name":"Nüsslein Volhard","first_name":"Christiane"}],"issue":"1","pmid":1,"_id":"4220","scopus_import":"1","title":"Genetic analysis of fin formation in the zebrafish, Danio rerio","intvolume":"       123","publication_status":"published","date_created":"2018-12-11T12:07:40Z","article_processing_charge":"No","extern":"1","volume":123,"external_id":{"pmid":["9007245 "]},"date_updated":"2022-08-04T10:01:17Z","citation":{"chicago":"Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Genetic Analysis of Fin Formation in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.255 \">https://doi.org/10.1242/dev.123.1.255 </a>.","ieee":"F. Van Eeden <i>et al.</i>, “Genetic analysis of fin formation in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 255–262, 1996.","ama":"Van Eeden F, Granato M, Schach U, et al. Genetic analysis of fin formation in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):255-262. doi:<a href=\"https://doi.org/10.1242/dev.123.1.255 \">10.1242/dev.123.1.255 </a>","apa":"Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter, P., … Nüsslein Volhard, C. (1996). Genetic analysis of fin formation in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.255 \">https://doi.org/10.1242/dev.123.1.255 </a>","ista":"Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Nüsslein Volhard C. 1996. Genetic analysis of fin formation in the zebrafish, Danio rerio. Development. 123(1), 255–262.","mla":"Van Eeden, Fredericus, et al. “Genetic Analysis of Fin Formation in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 255–62, doi:<a href=\"https://doi.org/10.1242/dev.123.1.255 \">10.1242/dev.123.1.255 </a>.","short":"F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, C. Nüsslein Volhard, Development 123 (1996) 255–262."},"year":"1996","abstract":[{"lang":"eng","text":"In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during embryogenesis. At larval stages the caudal fin fold is replaced by four different fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins are formed, We have identified a total of 118 mutations affecting larval fin formation, Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal and pectoral fin folds, Most mutants survive to adulthood and form a surprisingly normal complement of adult fins, Mutations in nine genes result in an increased or reduced size of the pectoral fins, Interestingly, in mutants of one of these genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium fails to expand, Expression of sonic hedgehog mRNA in the posterior mesenchyme of the pectoral fin bud is initiated in dak embryos, but not maintained, Mutations in five other genes affect adult fin but not larval fin development, Two mutants, longfin (lof) and another longfin (alf) have generally longer fins. Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins, Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported."}],"doi":"10.1242/dev.123.1.255 ","day":"01","language":[{"iso":"eng"}],"publication":"Development","month":"12","oa_version":"Published Version","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/255/39327/Genetic-analysis-of-fin-formation-in-the-zebrafish"}],"date_published":"1996-12-01T00:00:00Z","type":"journal_article","oa":1,"publist_id":"1896","publication_identifier":{"issn":["0950-1991"]}},{"page":"153 - 164","quality_controlled":"1","article_type":"original","publisher":"Company of Biologists","author":[{"first_name":"Fredericus","last_name":"Van Eeden","full_name":"Van Eeden, Fredericus"},{"first_name":"Michael","last_name":"Granato","full_name":"Granato, Michael"},{"last_name":"Schach","first_name":"Ursula","full_name":"Schach, Ursula"},{"full_name":"Brand, Michael","last_name":"Brand","first_name":"Michael"},{"full_name":"Furutani Seiki, Makoto","first_name":"Makoto","last_name":"Furutani Seiki"},{"first_name":"Pascal","last_name":"Haffter","full_name":"Haffter, Pascal"},{"full_name":"Hammerschmidt, Matthias","last_name":"Hammerschmidt","first_name":"Matthias"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566"},{"first_name":"Yunjin","last_name":"Jiang","full_name":"Jiang, Yunjin"},{"last_name":"Kane","first_name":"Donald","full_name":"Kane, Donald"},{"last_name":"Kelsh","first_name":"Robert","full_name":"Kelsh, Robert"},{"full_name":"Mullins, Mary","first_name":"Mary","last_name":"Mullins"},{"full_name":"Odenthal, Jörg","last_name":"Odenthal","first_name":"Jörg"},{"full_name":"Warga, Rachel","last_name":"Warga","first_name":"Rachel"},{"full_name":"Allende, Miguel","last_name":"Allende","first_name":"Miguel"},{"last_name":"Weinberg","first_name":"Eric","full_name":"Weinberg, Eric"},{"first_name":"Christiane","last_name":"Nüsslein Volhard","full_name":"Nüsslein Volhard, Christiane"}],"issue":"1","_id":"4222","pmid":1,"scopus_import":"1","title":"Mutations affecting somite formation and patterning in the zebrafish, Danio rerio","intvolume":"       123","publication_status":"published","date_created":"2018-12-11T12:07:41Z","article_processing_charge":"No","extern":"1","acknowledgement":"We would like to thank P. Ingham and T. Whitfield for valuable comments on the manuscript and cDNA probes, S. Schulte-Merker for the Ntl antibody and J. Eisen and R. BreMiller for the znp-1 antibody.","volume":123,"external_id":{"pmid":["9007237 "]},"date_updated":"2022-08-04T09:29:56Z","citation":{"ieee":"F. Van Eeden <i>et al.</i>, “Mutations affecting somite formation and patterning in the zebrafish, Danio rerio,” <i>Development</i>, vol. 123, no. 1. Company of Biologists, pp. 153–164, 1996.","chicago":"Van Eeden, Fredericus, Michael Granato, Ursula Schach, Michael Brand, Makoto Furutani Seiki, Pascal Haffter, Matthias Hammerschmidt, et al. “Mutations Affecting Somite Formation and Patterning in the Zebrafish, Danio Rerio.” <i>Development</i>. Company of Biologists, 1996. <a href=\"https://doi.org/10.1242/dev.123.1.153\">https://doi.org/10.1242/dev.123.1.153</a>.","apa":"Van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani Seiki, M., Haffter, P., … Nüsslein Volhard, C. (1996). Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.123.1.153\">https://doi.org/10.1242/dev.123.1.153</a>","ama":"Van Eeden F, Granato M, Schach U, et al. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. <i>Development</i>. 1996;123(1):153-164. doi:<a href=\"https://doi.org/10.1242/dev.123.1.153\">10.1242/dev.123.1.153</a>","ista":"Van Eeden F, Granato M, Schach U, Brand M, Furutani Seiki M, Haffter P, Hammerschmidt M, Heisenberg C-PJ, Jiang Y, Kane D, Kelsh R, Mullins M, Odenthal J, Warga R, Allende M, Weinberg E, Nüsslein Volhard C. 1996. Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development. 123(1), 153–164.","mla":"Van Eeden, Fredericus, et al. “Mutations Affecting Somite Formation and Patterning in the Zebrafish, Danio Rerio.” <i>Development</i>, vol. 123, no. 1, Company of Biologists, 1996, pp. 153–64, doi:<a href=\"https://doi.org/10.1242/dev.123.1.153\">10.1242/dev.123.1.153</a>.","short":"F. Van Eeden, M. Granato, U. Schach, M. Brand, M. Furutani Seiki, P. Haffter, M. Hammerschmidt, C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, M. Mullins, J. Odenthal, R. Warga, M. Allende, E. Weinberg, C. Nüsslein Volhard, Development 123 (1996) 153–164."},"year":"1996","abstract":[{"lang":"eng","text":"Somitogenesis is the basis of segmentation of the mesoderm in the trunk and tail of vertebrate embryos, Two groups of mutants with defects in this patterning process have been isolated in our screen for zygotic mutations affecting the embryonic development of the zebrafish (Danio rerio), In mutants of the first group, boundaries between individual somites are invisible early on, although the paraxial mesoderm is present, Later, irregular boundaries between somites are present, Mutations infused somites (fss) and beamter (bea) affect all somites, whereas mutations in deadly seven (des), after eight (aei) and white tail (wit) only affect the more posterior somites, Mutants of all genes but wit are homozygous viable and fertile, Skeletal stainings and the expression pattern of myoD and snail1 suggest that anteroposterior patterning within individual somites is abnormal, In the second group of mutants, formation of the horizontal myoseptum, which separates the dorsal and ventral part of the myotome, is reduced, Six genes have been defined in this group (you-type genes), yea-too mutants show the most severe phenotype; in these the adaxial cells, muscle pioneers and the primary motoneurons are affected, in addition to the horizontal myoseptum. The horizontal myoseptum is also missing in mutants that lack a notochord. The similarity of the somite phenotype in mutants lacking the notochord and in the you-type mutants suggests that the genes mutated in these two groups are involved in a signaling pathway from the notochord, important for patterning of the somites."}],"doi":"10.1242/dev.123.1.153","day":"01","language":[{"iso":"eng"}],"publication":"Development","month":"12","oa_version":"Published Version","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","main_file_link":[{"open_access":"1","url":"https://journals.biologists.com/dev/article/123/1/153/39329/Mutations-affecting-somite-formation-and"}],"date_published":"1996-12-01T00:00:00Z","type":"journal_article","publist_id":"1895","oa":1,"publication_identifier":{"issn":["0950-1991"]}},{"_id":"4292","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","author":[{"full_name":"Partridge, Linda","last_name":"Partridge","first_name":"Linda"},{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"issue":"1375","oa_version":"None","publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:08:05Z","month":"10","title":"On measuring the rate of ageing","intvolume":"       263","page":"1365 - 1371","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"Royal Society of London","date_updated":"2022-07-04T12:59:56Z","citation":{"ieee":"L. Partridge and N. H. Barton, “On measuring the rate of ageing,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 263, no. 1375. Royal Society of London, pp. 1365–1371, 1996.","chicago":"Partridge, Linda, and Nicholas H Barton. “On Measuring the Rate of Ageing.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society of London, 1996. <a href=\"https://doi.org/10.1098/rspb.1996.0200\">https://doi.org/10.1098/rspb.1996.0200</a>.","ama":"Partridge L, Barton NH. On measuring the rate of ageing. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 1996;263(1375):1365-1371. doi:<a href=\"https://doi.org/10.1098/rspb.1996.0200\">10.1098/rspb.1996.0200</a>","apa":"Partridge, L., &#38; Barton, N. H. (1996). On measuring the rate of ageing. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rspb.1996.0200\">https://doi.org/10.1098/rspb.1996.0200</a>","ista":"Partridge L, Barton NH. 1996. On measuring the rate of ageing. Proceedings of the Royal Society of London Series B Biological Sciences. 263(1375), 1365–1371.","short":"L. Partridge, N.H. Barton, Proceedings of the Royal Society of London Series B Biological Sciences 263 (1996) 1365–1371.","mla":"Partridge, Linda, and Nicholas H. Barton. “On Measuring the Rate of Ageing.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 263, no. 1375, Royal Society of London, 1996, pp. 1365–71, doi:<a href=\"https://doi.org/10.1098/rspb.1996.0200\">10.1098/rspb.1996.0200</a>."},"year":"1996","date_published":"1996-10-22T00:00:00Z","type":"journal_article","doi":"10.1098/rspb.1996.0200","day":"22","publication_identifier":{"issn":["0950-1193"]},"abstract":[{"lang":"eng","text":"Ageing, or senescence, is a decline in state at later ages that is manifested through a reduction in survival and fecundity. Ageing means that reproductive prospects and hence the life history options (trade-offs) open to the organism decline. Evolutionary theories of ageing suggest that it evolves in response to the level of externally imposed mortality and insults to fertility, either as part of life history optimization or as a result of mutation pressure. Several recent empirical and theoretical studies have produced apparently anomalous results. Some have suggested that the rate of ageing can decline at later ages, others that demographic evidence for ageing can appear in parallel with an improvement in state. All of these studies used measures of ageing that would not be expected to give an accurate reflection of changes in the state of the organism with age. We propose that Fisher's `reproductive value' is a natural measure of state at each age, which includes prospects for both survival and reproduction. If this measure is used, the apparently anomalous findings are not at variance with evolutionary theories of ageing."}],"publist_id":"1786","volume":263,"main_file_link":[{"url":"https://royalsocietypublishing.org/doi/abs/10.1098/rspb.1996.0200"}],"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public"},{"citation":{"apa":"Barton, N. H., &#38; Wilson, I. (1996). Genealogies and geography. In <i>New uses for new phylogenies</i> (pp. 23–56). Oxford University Press. <a href=\"https://doi.org/10.1098/rstb.1995.0090\">https://doi.org/10.1098/rstb.1995.0090</a>","ama":"Barton NH, Wilson I. Genealogies and geography. In: <i>New Uses for New Phylogenies</i>. Oxford University Press; 1996:23-56. doi:<a href=\"https://doi.org/10.1098/rstb.1995.0090\">10.1098/rstb.1995.0090</a>","ieee":"N. H. Barton and I. Wilson, “Genealogies and geography,” in <i>New uses for new phylogenies</i>, Oxford University Press, 1996, pp. 23–56.","chicago":"Barton, Nicholas H, and Ian Wilson. “Genealogies and Geography.” In <i>New Uses for New Phylogenies</i>, 23–56. Oxford University Press, 1996. <a href=\"https://doi.org/10.1098/rstb.1995.0090\">https://doi.org/10.1098/rstb.1995.0090</a>.","mla":"Barton, Nicholas H., and Ian Wilson. “Genealogies and Geography.” <i>New Uses for New Phylogenies</i>, Oxford University Press, 1996, pp. 23–56, doi:<a href=\"https://doi.org/10.1098/rstb.1995.0090\">10.1098/rstb.1995.0090</a>.","short":"N.H. Barton, I. Wilson, in:, New Uses for New Phylogenies, Oxford University Press, 1996, pp. 23–56.","ista":"Barton NH, Wilson I. 1996.Genealogies and geography. In: New uses for new phylogenies. , 23–56."},"year":"1996","date_updated":"2022-08-04T08:59:18Z","external_id":{"pmid":["8748019"]},"type":"book_chapter","date_published":"1996-01-01T00:00:00Z","publication_identifier":{"isbn":["978-0198549840"]},"day":"01","doi":"10.1098/rstb.1995.0090","publist_id":"1783","abstract":[{"text":"Any sample of genes traces back to a single common ancestor. Each gene also has other properties: its sequence, its geographic location and the phenotype and fitness of the organism that carries it. With sexual reproduction, different genes have different genealogies, which gives us much more information, but also greatly complicates population genetic analysis. We review the close relation between the distribution of genealogies and the classic theory of identity by descent in spatially structured populations, and develop a simple diffusion approximation to the distribution of coalescence times in a homogeneous two-dimensional habitat. This shows that when neighbourhood size is large (as in most populations) only a small fraction of pairs of genes are closely related, and only this fraction gives information about current rates of gene flow. The increase of spatial dispersion with lineage age is thus a poor estimator of gene flow. The bulk of the genealogy depends on the long-term history of the population; we discuss ways of inferring this history from the concordance between genealogies across loci.","lang":"eng"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public","extern":"1","pmid":1,"_id":"4294","publication":"New uses for new phylogenies","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"},{"full_name":"Wilson, Ian","last_name":"Wilson","first_name":"Ian"}],"date_created":"2018-12-11T12:08:05Z","article_processing_charge":"No","publication_status":"published","oa_version":"None","month":"01","title":"Genealogies and geography","quality_controlled":"1","page":"23 - 56","language":[{"iso":"eng"}],"publisher":"Oxford University Press"},{"date_updated":"2022-07-07T09:28:28Z","citation":{"apa":"Barton, N. H. (1996). Speciation: more than the sum of its parts. In <i>Current Biology</i> (Vol. 6, pp. 1244–1246). Cell Press. <a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">https://doi.org/10.1016/S0960-9822(02)70707-0</a>","ama":"Barton NH. Speciation: more than the sum of its parts. In: <i>Current Biology</i>. Vol 6. Cell Press; 1996:1244-1246. doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">10.1016/S0960-9822(02)70707-0</a>","chicago":"Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” In <i>Current Biology</i>, 6:1244–46. Cell Press, 1996. <a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">https://doi.org/10.1016/S0960-9822(02)70707-0</a>.","ieee":"N. H. Barton, “Speciation: more than the sum of its parts,” in <i>Current Biology</i>, vol. 6, Cell Press, 1996, pp. 1244–1246.","mla":"Barton, Nicholas H. “Speciation: More than the Sum of Its Parts.” <i>Current Biology</i>, vol. 6, Cell Press, 1996, pp. 1244–46, doi:<a href=\"https://doi.org/10.1016/S0960-9822(02)70707-0\">10.1016/S0960-9822(02)70707-0</a>.","short":"N.H. Barton, in:, Current Biology, Cell Press, 1996, pp. 1244–1246.","ista":"Barton NH. 1996.Speciation: more than the sum of its parts. In: Current Biology. vol. 6, 1244–1246."},"year":"1996","external_id":{"pmid":["8939554"]},"doi":"10.1016/S0960-9822(02)70707-0","day":"01","abstract":[{"text":"Genetic studies are beginning to provide insights into the evolutionary processes that reduce the fitness of hybrids between recently diverged species. However, the deleterious gene interactions responsible for this fitness reduction are still poorly understood.","lang":"eng"}],"volume":6,"acknowledgement":"Thanks to Brian Charlesworth, Jerry Coyne, Allen Orr and Michael Turelli for their comments on this note, and to the BBSRC and NERC for financial support.","extern":"1","_id":"4295","pmid":1,"scopus_import":"1","author":[{"full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"publication_status":"published","article_processing_charge":"No","date_created":"2018-12-11T12:08:06Z","title":"Speciation: more than the sum of its parts","intvolume":"         6","page":"1244 - 1246","quality_controlled":"1","publisher":"Cell Press","date_published":"1996-10-01T00:00:00Z","type":"book_chapter","publication_identifier":{"issn":["0960-9822"]},"oa":1,"publist_id":"1781","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0960982202707070?via%3Dihub"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Current Biology","oa_version":"Published Version","month":"10","language":[{"iso":"eng"}]},{"title":"The Theory of Rectangular Hybrid Automata","month":"01","oa_version":"None","publication_status":"published","date_created":"2018-12-11T12:08:45Z","article_processing_charge":"No","author":[{"first_name":"Peter","last_name":"Kopke","full_name":"Kopke, Peter"}],"_id":"4419","publisher":"Cornell University","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"A {\\em hybrid automaton\\/} consists of a finite automaton interacting with a dynamical system. Hybrid automata are used to model embedded controllers and other systems that consist of interacting discrete and continuous components. A hybrid automaton is {\\em rectangular\\/} if each of its continuous variables~x satisfies a nondeterministic differential equation of the form a≤dxdt≤b, where a and~b are rational constants. Rectangular hybrid automata are particularly useful for the analysis of communication protocols in which local clocks have bounded drift, and for the conservative approximation of systems with more complex continuous behavior. We examine several verification problems on the class of rectangular hybrid automata, including reachability, temporal logic model checking, and controller synthesis. Both dense-time and discrete-time models are considered. We identify subclasses of rectangular hybrid automata for which these problems are decidable and give complexity analyses. An investigation of the structural properties of rectangular hybrid automata is undertaken. One method for proving the decidability of verification problems on infinite-state systems is to find finite quotient systems on which analysis can proceed. Three state-space equivalence relations with strong connections to temporal logic are bisimilarity, similarity, and language equivalence. We characterize the quotient spaces of rectangular hybrid automata with respect to these equivalence relations."}],"supervisor":[{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724","last_name":"Henzinger","first_name":"Thomas A"}],"publist_id":"312","day":"01","date_published":"1996-01-01T00:00:00Z","type":"dissertation","date_updated":"2022-07-06T15:11:24Z","citation":{"ista":"Kopke P. 1996. The Theory of Rectangular Hybrid Automata. Cornell University.","mla":"Kopke, Peter. <i>The Theory of Rectangular Hybrid Automata</i>. Cornell University, 1996.","short":"P. Kopke, The Theory of Rectangular Hybrid Automata, Cornell University, 1996.","ieee":"P. Kopke, “The Theory of Rectangular Hybrid Automata,” Cornell University, 1996.","chicago":"Kopke, Peter. “The Theory of Rectangular Hybrid Automata.” Cornell University, 1996.","apa":"Kopke, P. (1996). <i>The Theory of Rectangular Hybrid Automata</i>. Cornell University.","ama":"Kopke P. The Theory of Rectangular Hybrid Automata. 1996."},"year":"1996","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","status":"public"}]