[{"acknowledgement":"This study was supported by a grant from the NSF.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","pmid":1,"_id":"883","publication_identifier":{"issn":["0028-0836"]},"extern":"1","publist_id":"6761","date_updated":"2023-04-13T10:33:44Z","volume":400,"article_processing_charge":"No","author":[{"first_name":"Alexey","full_name":"Kondrashov, Alexey","last_name":"Kondrashov"},{"id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","first_name":"Fyodor","full_name":"Kondrashov, Fyodor","last_name":"Kondrashov","orcid":"0000-0001-8243-4694"}],"abstract":[{"text":"Sympatric speciation, the origin of two or more species from a single local population, has almost certainly been involved in formation of several species flocks, and may be fairly common in nature. The most straightforward scenario for sympatric speciation requires disruptive selection favouring two substantially different phenotypes, and consists of the evolution of reproductive isolation between them followed by the elimination of all intermediate phenotypes. Here we use the hypergeometric phenotypic model to show that sympatric speciation is possible even when fitness and mate choice depend on different quantitative traits, so that speciation must involve formation of covariance between these traits. The increase in the number of variable loci affecting fitness facilitates sympatric speciation, whereas the increase in the number of variable loci affecting mate choice has the opposite effect. These predictions may enable more cases of sympatric speciation to be identified.","lang":"eng"}],"publication_status":"published","citation":{"mla":"Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative Traits in the Course of Sympatric Speciation.” Nature, vol. 400, no. 6742, Nature Publishing Group, 1999, pp. 351–54, doi:10.1038/22514.","ama":"Kondrashov A, Kondrashov F. Interactions among quantitative traits in the course of sympatric speciation. Nature. 1999;400(6742):351-354. doi:10.1038/22514","short":"A. Kondrashov, F. Kondrashov, Nature 400 (1999) 351–354.","ista":"Kondrashov A, Kondrashov F. 1999. Interactions among quantitative traits in the course of sympatric speciation. Nature. 400(6742), 351–354.","ieee":"A. Kondrashov and F. Kondrashov, “Interactions among quantitative traits in the course of sympatric speciation,” Nature, vol. 400, no. 6742. Nature Publishing Group, pp. 351–354, 1999.","apa":"Kondrashov, A., & Kondrashov, F. (1999). Interactions among quantitative traits in the course of sympatric speciation. Nature. Nature Publishing Group. https://doi.org/10.1038/22514","chicago":"Kondrashov, Alexey, and Fyodor Kondrashov. “Interactions among Quantitative Traits in the Course of Sympatric Speciation.” Nature. Nature Publishing Group, 1999. https://doi.org/10.1038/22514."},"external_id":{"pmid":["10432111"]},"title":"Interactions among quantitative traits in the course of sympatric speciation","doi":"10.1038/22514","year":"1999","page":"351 - 354","issue":"6742","publication":"Nature","status":"public","intvolume":" 400","type":"journal_article","day":"01","date_created":"2018-12-11T11:49:00Z","language":[{"iso":"eng"}],"publisher":"Nature Publishing Group","scopus_import":"1","date_published":"1999-07-01T00:00:00Z","article_type":"original","month":"07"},{"article_type":"original","date_published":"1999-01-01T00:00:00Z","month":"01","language":[{"iso":"eng"}],"publisher":"Springer","scopus_import":"1","date_created":"2018-12-11T12:09:35Z","type":"journal_article","day":"01","status":"public","intvolume":" 15","page":"7 - 48","issue":"1","publication":"Formal Methods in System Design","doi":"10.1023/A:1008739929481","year":"1999","title":"Reactive modules","publication_status":"published","citation":{"ista":"Alur R, Henzinger TA. 1999. Reactive modules. Formal Methods in System Design. 15(1), 7–48.","short":"R. Alur, T.A. Henzinger, Formal Methods in System Design 15 (1999) 7–48.","mla":"Alur, Rajeev, and Thomas A. Henzinger. “Reactive Modules.” Formal Methods in System Design, vol. 15, no. 1, Springer, 1999, pp. 7–48, doi:10.1023/A:1008739929481.","ama":"Alur R, Henzinger TA. Reactive modules. Formal Methods in System Design. 1999;15(1):7-48. doi:10.1023/A:1008739929481","chicago":"Alur, Rajeev, and Thomas A Henzinger. “Reactive Modules.” Formal Methods in System Design. Springer, 1999. https://doi.org/10.1023/A:1008739929481.","apa":"Alur, R., & Henzinger, T. A. (1999). Reactive modules. Formal Methods in System Design. Springer. https://doi.org/10.1023/A:1008739929481","ieee":"R. Alur and T. A. Henzinger, “Reactive modules,” Formal Methods in System Design, vol. 15, no. 1. Springer, pp. 7–48, 1999."},"author":[{"full_name":"Alur, Rajeev","last_name":"Alur","first_name":"Rajeev"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","last_name":"Henzinger","orcid":"0000−0002−2985−7724","first_name":"Thomas A"}],"abstract":[{"lang":"eng","text":"We present a formal model for concurrent systems. The model represents synchronous and asynchronous components in a uniform framework that supports compositional (assume-guarantee) and hierarchical (stepwise-refinement) design and verification. While synchronous models are based on a notion of atomic computation step, and asynchronous models remove that notion by introducing stuttering, our model is based on a flexible notion of what constitutes a computation step: by applying an abstraction operator to a system, arbitrarily many consecutive steps can be collapsed into a single step. The abstraction operator, which may turn an asynchronous system into a synchronous one, allows us to describe systems at various levels of temporal detail. For describing systems at various levels of spatial detail, we use a hiding operator that may turn a synchronous system into an asynchronous one. We illustrate the model with diverse examples from synchronous circuits, asynchronous shared-memory programs, and synchronous message-passing protocols.\r\n"}],"publist_id":"125","volume":15,"date_updated":"2022-09-02T08:45:58Z","article_processing_charge":"No","acknowledgement":"We thank Albert Benveniste, Bob Kurshan, Ken McMillan, Amir Pnueli, and the VIS group at UC Berkeley for fruitful discussions. We also thank the anonymous referees for suggesting improvements. Alur was supported in part by the DARPA/NASA grant NAG2-1214 and Henzinger was supported in part by the ONR YIP award N00014-95-1-0520, the\r\nNSF CAREER award CCR-9501708, the NSF grant CCR-9504469, the DARPA/NASA grant NAG2-1214, and by the SRC contract 97-DC-324.041.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","_id":"4582","extern":"1","publication_identifier":{"issn":["0925-9856"]}},{"day":"01","type":"conference","intvolume":" 1536","status":"public","publication":"Proceedings of the International Symposium on Compositionality","page":"23 - 60","month":"01","date_published":"1999-01-01T00:00:00Z","publisher":"Springer","scopus_import":"1","language":[{"iso":"eng"}],"conference":{"start_date":"1997-09-08","name":"COMPOS: Compositionality","location":"Bad Malente, Germany","end_date":"1997-09-12"},"date_created":"2018-12-11T12:09:41Z","publication_status":"published","citation":{"chicago":"Alur, Rajeev, Thomas A Henzinger, and Orna Kupferman. “Alternating-Time Temporal Logic.” In Proceedings of the International Symposium on Compositionality, 1536:23–60. Springer, 1999. https://doi.org/10.1007/3-540-49213-5_2.","apa":"Alur, R., Henzinger, T. A., & Kupferman, O. (1999). Alternating-time temporal logic. In Proceedings of the International Symposium on Compositionality (Vol. 1536, pp. 23–60). Bad Malente, Germany: Springer. https://doi.org/10.1007/3-540-49213-5_2","ieee":"R. Alur, T. A. Henzinger, and O. Kupferman, “Alternating-time temporal logic,” in Proceedings of the International Symposium on Compositionality, Bad Malente, Germany, 1999, vol. 1536, pp. 23–60.","short":"R. Alur, T.A. Henzinger, O. Kupferman, in:, Proceedings of the International Symposium on Compositionality, Springer, 1999, pp. 23–60.","ista":"Alur R, Henzinger TA, Kupferman O. 1999. Alternating-time temporal logic. Proceedings of the International Symposium on Compositionality. COMPOS: Compositionality, LNCS, vol. 1536, 23–60.","mla":"Alur, Rajeev, et al. “Alternating-Time Temporal Logic.” Proceedings of the International Symposium on Compositionality, vol. 1536, Springer, 1999, pp. 23–60, doi:10.1007/3-540-49213-5_2.","ama":"Alur R, Henzinger TA, Kupferman O. Alternating-time temporal logic. In: Proceedings of the International Symposium on Compositionality. Vol 1536. Springer; 1999:23-60. doi:10.1007/3-540-49213-5_2"},"abstract":[{"text":"Temporal logic comes in two varieties: linear-time temporal logic assumes implicit universal quantification over all paths that are generated by system moves; branching-time temporal logic allows explicit existential and universal quantification over all paths. We introduce a third, more general variety of temporal logic: alternating-time temporal logic offers selective quantification over those paths that are possible outcomes of games, such as the game in which the system and the environment alternate moves. While linear-time and branching-time logics are natural specification languages for closed systems, alternating-time logics are natural specification languages for open systems. For example, by preceding the temporal operator “eventually” with a selective path quantifier, we can specify that in the game between the system and the environment, the system has a strategy to reach a certain state. Also the problems of receptiveness, realizability, and controllability can be formulated as model-checking problems for alternating-time formulas.\r\nDepending on whether we admit arbitrary nesting of selective path quantifiers and temporal operators, we obtain the two alternating-time temporal logics ATL and ATL. We interpret the formulas of ATL and ATL over alternating transition systems. While in ordinary transition systems, each transition corresponds to a possible step of the system, in alternating transition systems, each transition corresponds to a possible move in the game between the system and the environment. Fair alternating transition systems can capture both synchronous and asynchronous compositions of open systems. For synchronous systems, the expressive power of ATL beyond CTL comes at no cost: the model-checking complexity of synchronous ATL is linear in the size of the system and the length of the formula. The symbolic model-checking algorithm for CTL extends with few modifications to synchronous ATL, and with some work, also to asynchronous ATL, whose model-checking complexity is quadratic. This makes ATL an obvious candidate for the automatic verification of open systems. In the case of ATL, the model-checking problem is closely related to the synthesis problem for linear-time formulas, and requires doubly exponential time for both synchronous and asynchronous systems.\r\nA preliminary version of this paper appeared in the Proceedings of the 38th IEEE Symposium on Foundations of Computer Science (FOCS 1997), pp. 100–109.","lang":"eng"}],"author":[{"first_name":"Rajeev","full_name":"Alur, Rajeev","last_name":"Alur"},{"orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A","last_name":"Henzinger","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Orna","full_name":"Kupferman, Orna","last_name":"Kupferman"}],"date_updated":"2022-09-01T14:23:41Z","volume":1536,"publist_id":"106","article_processing_charge":"No","_id":"4601","extern":"1","publication_identifier":{"isbn":["9783540654933"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"This work was supported in part by the ONR YIP award N00014-95-1-0520, by the NSF CAREER award CCR-9501708, by the NSF grant CCR-9504469, by the AFOSR contract F49620-93-1-0056, by the ARO MURI grant DAAH-04-96-1-0341, by the ARPA grant NAG2-892, and by the SRC contract 97-DC-324.041.","oa_version":"None","quality_controlled":"1","year":"1999","doi":"10.1007/3-540-49213-5_2","title":"Alternating-time temporal logic","alternative_title":["LNCS"]},{"conference":{"start_date":"1999-08-24","end_date":"1999-08-27","location":"Eindhoven, The Netherlands","name":"CONCUR: Concurrency Theory"},"date_created":"2018-12-11T12:09:42Z","month":"01","date_published":"1999-01-01T00:00:00Z","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Proceedings of the 10th International Conference on Concurrency Theory","page":"82 - 97","day":"01","type":"conference","intvolume":" 1664","status":"public","alternative_title":["LNCS"],"doi":"10.1007/3-540-48320-9_8","year":"1999","title":"Automating modular verification","date_updated":"2022-09-01T14:15:35Z","publist_id":"105","volume":1664,"article_processing_charge":"No","_id":"4602","extern":"1","publication_identifier":{"isbn":["9783540664253"]},"acknowledgement":"This research was supported in part by the NSF CAREER award CCR-9734115, by the NSF CAREER award CCR-9501708, by the DARPA (NASA Ames) grant NAG2-1214, by the DARPA (Wright-Patterson AFB) grant F33615-98-C-3614, by the ARO MURI grant DAAH- 04-96-1-0341, and by the Gigascale Silicon Research Center.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","publication_status":"published","citation":{"mla":"Alur, Rajeev, et al. “Automating Modular Verification.” Proceedings of the 10th International Conference on Concurrency Theory, vol. 1664, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1999, pp. 82–97, doi:10.1007/3-540-48320-9_8.","ama":"Alur R, De Alfaro L, Henzinger TA, Mang F. Automating modular verification. In: Proceedings of the 10th International Conference on Concurrency Theory. Vol 1664. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 1999:82-97. doi:10.1007/3-540-48320-9_8","short":"R. Alur, L. De Alfaro, T.A. Henzinger, F. Mang, in:, Proceedings of the 10th International Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1999, pp. 82–97.","ista":"Alur R, De Alfaro L, Henzinger TA, Mang F. 1999. Automating modular verification. Proceedings of the 10th International Conference on Concurrency Theory. CONCUR: Concurrency Theory, LNCS, vol. 1664, 82–97.","apa":"Alur, R., De Alfaro, L., Henzinger, T. A., & Mang, F. (1999). Automating modular verification. In Proceedings of the 10th International Conference on Concurrency Theory (Vol. 1664, pp. 82–97). Eindhoven, The Netherlands: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.1007/3-540-48320-9_8","ieee":"R. Alur, L. De Alfaro, T. A. Henzinger, and F. Mang, “Automating modular verification,” in Proceedings of the 10th International Conference on Concurrency Theory, Eindhoven, The Netherlands, 1999, vol. 1664, pp. 82–97.","chicago":"Alur, Rajeev, Luca De Alfaro, Thomas A Henzinger, and Freddy Mang. “Automating Modular Verification.” In Proceedings of the 10th International Conference on Concurrency Theory, 1664:82–97. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 1999. https://doi.org/10.1007/3-540-48320-9_8."},"abstract":[{"text":"Modular techniques for automatic verification attempt to overcome the state-explosion problem by exploiting the modular structure naturally present in many system designs. Unlike other tasks in the verification of finite-state systems, current modular techniques rely heavily on user guidance. In particular, the user is typically required to construct module abstractions that are neither too detailed as to render insufficient benefits in state exploration, nor too coarse as to invalidate the desired systemproperties. In this paper, we construct abstractmodules automatically, using reachability and controllability information about the concrete modules. This allows us to leverage automatic verification techniques by applying them in layers: first we compute on the state spaces of system components, then we use the results for constructing abstractions, and finally we compute on the abstract state space of the system. Our experimental results indicate that if reachability and controllability information is used in the construction of abstractions, the resulting abstract modules are often significantly smaller than the concrete modules and can drastically reduce the space and time requirements for verification.","lang":"eng"}],"author":[{"last_name":"Alur","full_name":"Alur, Rajeev","first_name":"Rajeev"},{"first_name":"Luca","last_name":"De Alfaro","full_name":"De Alfaro, Luca"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","last_name":"Henzinger","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724"},{"first_name":"Freddy","last_name":"Mang","full_name":"Mang, Freddy"}]},{"abstract":[{"lang":"eng","text":"In this paper we present an analysis of an AltaVista Search Engine query log consisting of approximately 1 billion entries for search requests over a period of six weeks. This represents almost 285 million user sessions, each an attempt to fill a single information need. We present an analysis of individual queries, query duplication, and query sessions. We also present results of a correlation analysis of the log entries, studying the interaction of terms within queries. Our data supports the conjecture that web users differ significantly from the user assumed in the standard information retrieval literature. Specifically, we show that web users type in short queries, mostly look at the first 10 results only, and seldom modify the query. This suggests that traditional information retrieval techniques may not work well for answering web search requests. The correlation analysis showed that the most highly correlated items are constituents of phrases. This result indicates it may be useful for search engines to consider search terms as parts of phrases even if the user did not explicitly specify them as such."}],"author":[{"first_name":"Craig","full_name":"Silverstein, Craig","last_name":"Silverstein"},{"full_name":"Marais, Hannes","last_name":"Marais","first_name":"Hannes"},{"first_name":"Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"first_name":"Michael","full_name":"Moricz, Michael","last_name":"Moricz"}],"citation":{"ista":"Silverstein C, Marais H, Henzinger MH, Moricz M. 1999. Analysis of a very large web search engine query log. ACM SIGIR Forum. 33(1), 6–12.","short":"C. Silverstein, H. Marais, M.H. Henzinger, M. Moricz, ACM SIGIR Forum 33 (1999) 6–12.","ama":"Silverstein C, Marais H, Henzinger MH, Moricz M. Analysis of a very large web search engine query log. ACM SIGIR Forum. 1999;33(1):6-12. doi:10.1145/331403.331405","mla":"Silverstein, Craig, et al. “Analysis of a Very Large Web Search Engine Query Log.” ACM SIGIR Forum, vol. 33, no. 1, Association for Computing Machinery, 1999, pp. 6–12, doi:10.1145/331403.331405.","chicago":"Silverstein, Craig, Hannes Marais, Monika H Henzinger, and Michael Moricz. “Analysis of a Very Large Web Search Engine Query Log.” ACM SIGIR Forum. Association for Computing Machinery, 1999. https://doi.org/10.1145/331403.331405.","ieee":"C. Silverstein, H. Marais, M. H. Henzinger, and M. Moricz, “Analysis of a very large web search engine query log,” ACM SIGIR Forum, vol. 33, no. 1. Association for Computing Machinery, pp. 6–12, 1999.","apa":"Silverstein, C., Marais, H., Henzinger, M. H., & Moricz, M. (1999). Analysis of a very large web search engine query log. ACM SIGIR Forum. Association for Computing Machinery. https://doi.org/10.1145/331403.331405"},"publication_status":"published","publication_identifier":{"issn":["0163-5840"]},"extern":"1","_id":"11895","quality_controlled":"1","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","date_updated":"2023-02-17T14:46:04Z","oa":1,"volume":33,"title":"Analysis of a very large web search engine query log","doi":"10.1145/331403.331405","year":"1999","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1145/331403.331405"}],"intvolume":" 33","status":"public","day":"01","type":"journal_article","publication":"ACM SIGIR Forum","issue":"1","page":"6-12","scopus_import":"1","publisher":"Association for Computing Machinery","language":[{"iso":"eng"}],"month":"01","date_published":"1999-01-01T00:00:00Z","article_type":"original","date_created":"2022-08-17T08:53:02Z"},{"month":"01","year":"1999","date_published":"1999-01-01T00:00:00Z","publisher":"Society for Industrial & Applied Mathematics","scopus_import":"1","title":"Scheduling multicasts on unit-capacity trees and meshes","language":[{"iso":"eng"}],"conference":{"name":"SODA: Symposium on Discrete Algorithms","location":"Baltimore, MD, United States","end_date":"1999-01-19","start_date":"1999-01-17"},"date_created":"2022-08-18T12:45:50Z","publication_status":"published","citation":{"ama":"Henzinger MH, Leonardi S. Scheduling multicasts on unit-capacity trees and meshes. In: 10th Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial & Applied Mathematics; 1999:438-447.","mla":"Henzinger, Monika H., and Stefano Leonardi . “Scheduling Multicasts on Unit-Capacity Trees and Meshes.” 10th Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial & Applied Mathematics, 1999, pp. 438–47.","short":"M.H. Henzinger, S. Leonardi , in:, 10th Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial & Applied Mathematics, 1999, pp. 438–447.","ista":"Henzinger MH, Leonardi S. 1999. Scheduling multicasts on unit-capacity trees and meshes. 10th Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium on Discrete Algorithms, 438–447.","apa":"Henzinger, M. H., & Leonardi , S. (1999). Scheduling multicasts on unit-capacity trees and meshes. In 10th Annual ACM-SIAM Symposium on Discrete Algorithms (pp. 438–447). Baltimore, MD, United States: Society for Industrial & Applied Mathematics.","ieee":"M. H. Henzinger and S. Leonardi , “Scheduling multicasts on unit-capacity trees and meshes,” in 10th Annual ACM-SIAM Symposium on Discrete Algorithms, Baltimore, MD, United States, 1999, pp. 438–447.","chicago":"Henzinger, Monika H, and Stefano Leonardi . “Scheduling Multicasts on Unit-Capacity Trees and Meshes.” In 10th Annual ACM-SIAM Symposium on Discrete Algorithms, 438–47. Society for Industrial & Applied Mathematics, 1999."},"day":"01","type":"conference","abstract":[{"text":"This paper studies the multicast routing and admission control problem on unit-capacity tree and mesh topologies in the throughput-model. The problem is a generalization of the edge-disjoint paths problem and is NPhard both on trees and meshes. We study both the offline and the online version of the problem: In the offline setting, we give the first\r\nconstant-factor approximation algorithm for trees, and an O((log log n)*)-factor approximation algorithm for meshes, where n is the number of nodes in the graph. In the online setting, we give the first polylogarithrnic competitive online algorithm for tree and mesh topologies. No polylogarithmic-competitive algorithm is possible on general network topologies [8] and there\r\nexists a polylogarithmic lower bound on the competitive ratio of any online algorithm on tree topologies [l]. We prove the same lower bound for meshes. ","lang":"eng"}],"status":"public","author":[{"first_name":"Monika H","full_name":"Henzinger, Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"first_name":"Stefano","full_name":"Leonardi , Stefano","last_name":"Leonardi "}],"publication":"10th Annual ACM-SIAM Symposium on Discrete Algorithms","date_updated":"2023-02-17T12:08:26Z","article_processing_charge":"No","page":"438-447","_id":"11925","publication_identifier":{"isbn":["0898714346"]},"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"None"},{"issue":"16","publication":"Journal of Neuroscience","type":"journal_article","day":"15","status":"public","intvolume":" 19","date_created":"2018-12-11T12:03:22Z","date_published":"1999-08-15T00:00:00Z","article_type":"original","month":"08","language":[{"iso":"eng"}],"publisher":"Society for Neuroscience","scopus_import":"1","oa":1,"date_updated":"2022-09-07T13:41:18Z","volume":19,"publist_id":"2943","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"Published Version","quality_controlled":"1","pmid":1,"_id":"3444","extern":"1","publication_identifier":{"issn":["0270-6474"]},"publication_status":"published","citation":{"chicago":"Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.","apa":"Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999","ieee":"J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network oscillations in the hippocampal CA1 region of the behaving rat,” Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.","short":"J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999).","ista":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. 19(16).","mla":"Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.","ama":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. 1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999"},"author":[{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"},{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"first_name":"András","last_name":"Czurkó","full_name":"Czurkó, András"},{"full_name":"Mamiya, Akira","last_name":"Mamiya","first_name":"Akira"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"}],"abstract":[{"lang":"eng","text":"This study examined intermittent, high-frequency (100-200 Hz) oscillatory patterns in the CA1 region of the hippocampus in the absence of theta activity, i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal activity was phase-locked not only to large amplitude (>7 SD from baseline) oscillatory events, which are present mainly during SPWs, but to smaller amplitude (<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple" frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz ("slow") oscillatory patterns. Fast ripple waves reversed just below the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves. These findings suggest that fast ripples emerge in the CA1 region, whereas slow (100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred to the CA1 field."}],"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/","open_access":"1"}],"doi":"10.1523/JNEUROSCI.19-16-j0001.1999","year":"1999","external_id":{"pmid":["10436076"]},"title":"Fast network oscillations in the hippocampal CA1 region of the behaving rat"},{"date_created":"2018-12-11T12:03:22Z","month":"07","date_published":"1999-07-15T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"Society for Neuroscience","language":[{"iso":"eng"}],"publication":"Journal of Neuroscience","issue":"14","page":"6191 - 6199","day":"15","type":"journal_article","intvolume":" 19","status":"public","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/"}],"doi":"10.1523/JNEUROSCI.19-14-06191.1999","year":"1999","title":"Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat","external_id":{"pmid":["10407055"]},"article_processing_charge":"No","date_updated":"2022-09-07T13:37:41Z","oa":1,"publist_id":"2942","volume":19,"publication_identifier":{"issn":["0270-6474"]},"extern":"1","_id":"3445","pmid":1,"oa_version":"Published Version","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and support and T. F. Freund for his comments on this manuscript.","citation":{"mla":"Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.","ama":"Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999","short":"G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 6191–6199.","ista":"Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 19(14), 6191–6199.","ieee":"G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society for Neuroscience, pp. 6191–6199, 1999.","apa":"Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999). Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999","chicago":"Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999."},"publication_status":"published","abstract":[{"lang":"eng","text":"The medial septal region and the hippocampus are connected reciprocally via GABAergic neurons, but the physiological role of this loop is still not well understood. In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta activity and extracellular units recorded in the medial septum and diagonal band of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%) were significantly suppressed during SPWs. Most cells inhibited during SPW (80%) fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal layer theta waves. Because both SPW and the negative peak of local theta waves correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron classes, the findings indicate that the activity of medial septal neurons can be negatively (during SPW) or positively (during theta waves) correlated with the activity of hippocampal interneurons. We hypothesize that the functional coupling between medial septal neurons and hippocampal interneurons varies in a state-dependent manner."}],"author":[{"first_name":"George","last_name":"Dragoi","full_name":"Dragoi, George"},{"last_name":"Carpi","full_name":"Carpi, Daniel","first_name":"Daniel"},{"first_name":"Michael","last_name":"Recce","full_name":"Recce, Michael"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","orcid":"0000-0002-5193-4036"},{"last_name":"Buzsáki","full_name":"Buzsáki, György","first_name":"György"}]},{"date_created":"2018-12-11T12:03:25Z","month":"01","date_published":"1999-01-01T00:00:00Z","publisher":"Springer","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Ionotropic Glutamate Receptors in the CNS","page":"309 - 339","day":"01","type":"book_chapter","intvolume":" 141","status":"public","alternative_title":["Handbook of experimental pharmacology"],"doi":"10.1007/978-3-662-08022-1_9","year":"1999","title":"Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS","editor":[{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hannah","last_name":"Monyer","full_name":"Monyer, Hannah"}],"volume":141,"publist_id":"2931","date_updated":"2022-09-07T13:30:23Z","article_processing_charge":"No","_id":"3456","extern":"1","publication_identifier":{"isbn":["9783642085390"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","oa_version":"None","publication_status":"published","citation":{"ama":"Monyer H, Jonas PM, Rossier J. Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In: Jonas PM, Monyer H, eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:309-339. doi:10.1007/978-3-662-08022-1_9","mla":"Monyer, Hannah, et al. “Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.” Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and Hannah Monyer, vol. 141, Springer, 1999, pp. 309–39, doi:10.1007/978-3-662-08022-1_9.","ista":"Monyer H, Jonas PM, Rossier J. 1999.Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In: Ionotropic Glutamate Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 309–339.","short":"H. Monyer, P.M. Jonas, J. Rossier, in:, P.M. Jonas, H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 309–339.","ieee":"H. Monyer, P. M. Jonas, and J. Rossier, “Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS,” in Ionotropic Glutamate Receptors in the CNS, vol. 141, P. M. Jonas and H. Monyer, Eds. Springer, 1999, pp. 309–339.","apa":"Monyer, H., Jonas, P. M., & Rossier, J. (1999). Molecular determinants controlling functional properties of AMPARs and NMDARs in the mammalian CNS. In P. M. Jonas & H. Monyer (Eds.), Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 309–339). Springer. https://doi.org/10.1007/978-3-662-08022-1_9","chicago":"Monyer, Hannah, Peter M Jonas, and Jean Rossier. “Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS.” In Ionotropic Glutamate Receptors in the CNS, edited by Peter M Jonas and Hannah Monyer, 141:309–39. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_9."},"abstract":[{"text":"L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and N-methyl-D-aspartate receptors (NMDARs) are the two major types of postsynaptic glutamate receptors (GluRs) that mediate excitatory synaptic transmission in the mammalian central nervous system (CNS). Both AMPARs and NMDARs are multimeric proteins, probably tetramers, formed by a variety of molecularly distinct subunits. AMPARs can be assembled from four types of subunits, termed GIuR-A, -B, -C, and -D (or, in an alternative nomenclature, G1uR1, G1uR2, GluR3, and G1uR4). Additional molecular diversity of AMPARs is generated by alternative splicing of the flip-flop module and RNA editing at the Q/R and R/G site. NMDARs are heteromers primarily assembled from NR1 subunits and NR2A, B, C, or D subunits. Various splice variants have been identified for the NR1 subunit, and a new NR3 subunit has been discovered recently. Considering all combinatorial possibilities, the molecular diversity of glutamate-receptor channels is considerable (HOLLMANN, this volume).","lang":"eng"}],"author":[{"first_name":"Hannah","full_name":"Monyer, Hannah","last_name":"Monyer"},{"first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Rossier, Jean","last_name":"Rossier","first_name":"Jean"}]},{"type":"book_chapter","publication_status":"published","citation":{"mla":"Geiger, Jörg, et al. “Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.” Ionotropic Glutamate Receptors in the CNS, edited by Hannah Monyer and Peter M Jonas, vol. 141, Springer, 1999, pp. 363–98, doi:10.1007/978-3-662-08022-1_11.","ama":"Geiger J, Roth A, Taskin B, Jonas PM. Glutamate-mediated synaptic excitation of cortical interneurons. In: Monyer H, Jonas PM, eds. Ionotropic Glutamate Receptors in the CNS. Vol 141. Springer; 1999:363-398. doi:10.1007/978-3-662-08022-1_11","short":"J. Geiger, A. Roth, B. Taskin, P.M. Jonas, in:, H. Monyer, P.M. Jonas (Eds.), Ionotropic Glutamate Receptors in the CNS, Springer, 1999, pp. 363–398.","ista":"Geiger J, Roth A, Taskin B, Jonas PM. 1999.Glutamate-mediated synaptic excitation of cortical interneurons. In: Ionotropic Glutamate Receptors in the CNS. Handbook of experimental pharmacology, vol. 141, 363–398.","ieee":"J. Geiger, A. Roth, B. Taskin, and P. M. Jonas, “Glutamate-mediated synaptic excitation of cortical interneurons,” in Ionotropic Glutamate Receptors in the CNS, vol. 141, H. Monyer and P. M. Jonas, Eds. Springer, 1999, pp. 363–398.","apa":"Geiger, J., Roth, A., Taskin, B., & Jonas, P. M. (1999). Glutamate-mediated synaptic excitation of cortical interneurons. In H. Monyer & P. M. Jonas (Eds.), Ionotropic Glutamate Receptors in the CNS (Vol. 141, pp. 363–398). Springer. https://doi.org/10.1007/978-3-662-08022-1_11","chicago":"Geiger, Jörg, Arnd Roth, Birol Taskin, and Peter M Jonas. “Glutamate-Mediated Synaptic Excitation of Cortical Interneurons.” In Ionotropic Glutamate Receptors in the CNS, edited by Hannah Monyer and Peter M Jonas, 141:363–98. Springer, 1999. https://doi.org/10.1007/978-3-662-08022-1_11."},"day":"01","status":"public","author":[{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"},{"first_name":"Arnd","last_name":"Roth","full_name":"Roth, Arnd"},{"full_name":"Taskin, Birol","last_name":"Taskin","first_name":"Birol"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804"}],"abstract":[{"text":"Principal neurons and interneurons are the two main classes of cells in cortical neuronal networks. Principal neurons (granule cells or pyramidal neurons) have transregional axonal projections and release glutamate onto their postsynaptic target cells. In contrast, interneurons have local, but often extensive, axonal arborizations and use γ-aminobutyric acid (GABA) as a transmitter. Although interneurons represent only approximately 10% of the neuronal population, they control the electrical activity of the entire network (FREUND and BUZSÁKI 1996). Interneurons forming inhibitory synapses on the somata or axon initial segments of their postsynaptic target cells are thought to set the threshold of action potential initiation (MILES et al. 1996) and can synchronize the collective activities of large principal neuron ensembles (COBB et al. 1995). In contrast, interneurons establishing inhibitory synapses mainly on dendrites could suppress dendritic Na+ or Ca2+ spikes (BUZSÁKI et al. 1996; MILES et al. 1996) and, thus, regulate plasticity at glutamatergic synapses in the cortex (DAVIES et al.1991).","lang":"eng"}],"intvolume":" 141","date_updated":"2022-09-07T13:25:46Z","publist_id":"2930","volume":141,"article_processing_charge":"No","page":"363 - 398","editor":[{"last_name":"Monyer","full_name":"Monyer, Hannah","first_name":"Hannah"},{"full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"publication":"Ionotropic Glutamate Receptors in the CNS","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","_id":"3457","publication_identifier":{"isbn":["9783642085390"]},"extern":"1","date_published":"1999-01-01T00:00:00Z","year":"1999","month":"01","doi":"10.1007/978-3-662-08022-1_11","language":[{"iso":"eng"}],"publisher":"Springer","title":"Glutamate-mediated synaptic excitation of cortical interneurons","alternative_title":["Handbook of experimental pharmacology"],"date_created":"2018-12-11T12:03:26Z"},{"citation":{"short":"M. Penttonen, N. Nurminen, R. Miettinen, J. Sirviö, D. Henze, J.L. Csicsvari, G. Buzsáki, Neuroscience 94 (1999) 735–743.","ista":"Penttonen M, Nurminen N, Miettinen R, Sirviö J, Henze D, Csicsvari JL, Buzsáki G. 1999. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. 94(3), 735–743.","mla":"Penttonen, Markku, et al. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience, vol. 94, no. 3, Elsevier, 1999, pp. 735–43, doi:10.1016/S0306-4522(99)00367-X.","ama":"Penttonen M, Nurminen N, Miettinen R, et al. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. 1999;94(3):735-743. doi:10.1016/S0306-4522(99)00367-X","chicago":"Penttonen, Markku, Nina Nurminen, Riitta Miettinen, Jouni Sirviö, Darrell Henze, Jozsef L Csicsvari, and György Buzsáki. “Ultra-Slow Oscillation (0.025 Hz) Triggers Hippocampal Afterdischarges in Wistar Rats.” Neuroscience. Elsevier, 1999. https://doi.org/10.1016/S0306-4522(99)00367-X.","apa":"Penttonen, M., Nurminen, N., Miettinen, R., Sirviö, J., Henze, D., Csicsvari, J. L., & Buzsáki, G. (1999). Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats. Neuroscience. Elsevier. https://doi.org/10.1016/S0306-4522(99)00367-X","ieee":"M. Penttonen et al., “Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats,” Neuroscience, vol. 94, no. 3. Elsevier, pp. 735–743, 1999."},"publication_status":"published","abstract":[{"text":"Oscillations in neuronal networks are assumed to serve various physiological functions, from coordination of motor patterns to perceptual binding of sensory information. Here, we describe an ultra-slow oscillation (0.025 Hz) in the hippocampus. Extracellular and intracellular activity was recorded from the CA1 and subicular regions in rats of the Wistar and Sprague-Dawley strains. anesthetized with urethane. in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s) occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast increase of population synchrony (100-250 Hz oscillation; “tonic” phase), followed by large-amplitude rhythmic waves and associated action potentials at gamma and beta frequency (15-50 Hz; “clonic” phase). The afterdischarges were bilaterally synchronous and terminated relatively abruptly without post-ictal depression. Single-pulse stimulation of the commissural input could trigger afterdischarges, but only at times when they were about to occur. Commissural stimulation evoked inhibitory postsynaptic potentials in pyramidal cells. However, when the stimulus triggered an afterdischarge, the inhibitory postsynaptic potential was absent and the cells remained depolarized during most of the afterdischarge. Afterdischarges were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal activity in intact, drug-free rats also revealed periodic excitability changes in the hippocampal network at 0.025 Hz. These findings indicate the presence of an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced afterdischarges in susceptible animals. We hypothesize that a transient failure of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.","lang":"eng"}],"author":[{"last_name":"Penttonen","full_name":"Penttonen, Markku","first_name":"Markku"},{"first_name":"Nina","last_name":"Nurminen","full_name":"Nurminen, Nina"},{"first_name":"Riitta","full_name":"Miettinen, Riitta","last_name":"Miettinen"},{"last_name":"Sirviö","full_name":"Sirviö, Jouni","first_name":"Jouni"},{"last_name":"Henze","full_name":"Henze, Darrell","first_name":"Darrell"},{"orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"}],"article_processing_charge":"No","volume":94,"date_updated":"2022-09-07T13:16:01Z","publist_id":"2870","publication_identifier":{"issn":["0306-4522"]},"extern":"1","pmid":1,"_id":"3515","oa_version":"None","quality_controlled":"1","acknowledgement":"This work was supported by the Academy of Finland (32391) and the NIH (NS34994, MH54671).","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","year":"1999","doi":"10.1016/S0306-4522(99)00367-X","title":"Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats","external_id":{"pmid":["10579564"]},"day":"01","type":"journal_article","intvolume":" 94","status":"public","publication":"Neuroscience","issue":"3","page":"735 - 743","month":"10","date_published":"1999-10-01T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"Elsevier","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:03:44Z"},{"day":"01","type":"journal_article","intvolume":" 19","status":"public","publication":"Journal of Neuroscience","issue":"21","page":"9497 - 9507","month":"11","date_published":"1999-11-01T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"Society for Neuroscience","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:03:45Z","citation":{"apa":"Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999","ieee":"Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay and time compression of recurring spike sequences in the hippocampus,” Journal of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507, 1999.","chicago":"Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.","ama":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999","mla":"Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.","ista":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 19(21), 9497–9507.","short":"Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 9497–9507."},"publication_status":"published","abstract":[{"lang":"eng","text":"Information in neuronal networks may be represented by the spatiotemporal patterns of spikes. Here we examined the temporal coordination of pyramidal cell spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained to run in a defined position in space (running wheel) to activate a selected group of pyramidal cells. A template-matching method and a joint probability map method were used for sequence search. Repeating spike sequences in excess of chance occurrence were examined by comparing the number of repeating sequences in the original spike trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four different shuffling procedures were used to control for the population dynamics of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies were present in both the awake and sleeping animal in excess of what might be predicted by random variations. Spike sequences observed during wheel running were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave sleep. We hypothesize that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience. Reactivation of acquired sequences may serve to consolidate information."}],"author":[{"full_name":"Nádasdy, Zoltán","last_name":"Nádasdy","first_name":"Zoltán"},{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"first_name":"András","last_name":"Czurkó","full_name":"Czurkó, András"},{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"}],"article_processing_charge":"No","date_updated":"2022-09-07T12:48:08Z","publist_id":"2866","volume":19,"oa":1,"extern":"1","publication_identifier":{"issn":["0270-6474"]},"_id":"3518","pmid":1,"quality_controlled":"1","oa_version":"Published Version","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and Matthew Wilson for their suggestions with data analysis and comments on this manuscript.","year":"1999","doi":"10.1523/JNEUROSCI.19-21-09497.1999","external_id":{"pmid":["10531452"]},"title":"Replay and time compression of recurring spike sequences in the hippocampus","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/"}]},{"title":"Sustained activation of hippocampal pyramidal cells by ‘space clamping' in a running wheel","external_id":{"pmid":["9987037"]},"doi":"10.1046/j.1460-9568.1999.00446.x","year":"1999","quality_controlled":"1","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"We thank M. Recce for continuous support, A. Berthoz for advice, K. Moorefor his participation in the early stages of the experiments, J. Lee for helpand C. King for his comments on the manuscript. This work was supportedby NIH (NS34994, MH54671), the Human Frontier Science Program (H.H.),the Hungarian Eo ̈tvo ̈s State Fellowship (A.C.) and the Soros Foundation (A.C.)","extern":"1","publication_identifier":{"issn":["0953-816X"]},"pmid":1,"_id":"3519","article_processing_charge":"No","publist_id":"2867","volume":11,"date_updated":"2022-09-07T13:09:08Z","author":[{"first_name":"András","full_name":"Czurkó, András","last_name":"Czurkó"},{"first_name":"Hajima","full_name":"Hirase, Hajima","last_name":"Hirase"},{"orcid":"0000-0002-5193-4036","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"first_name":"György","full_name":"Buzsáki, György","last_name":"Buzsáki"}],"abstract":[{"lang":"eng","text":"In contrast to sensory cortical areas of the brain, the relevant physiological inputs to the hippocampus, leading to selective activation of pyramidal cells, are largely unknown. Pyramidal cells are thought to be phasically activated by spatial cues and a variety of sensory and motor stimuli. Here, we used a behavioural `space clamp' method, which involved the confinement of the actively running animal in a defined position in space (running wheel) and kept sensory inputs constant. Twelve percent of the recorded CA1 pyramidal cells were selectively active while the rat was running in the wheel. Cell firing was specific to the direction of running and disappeared after rotating the recording apparatus. The discharge frequency of pyramidal cells and interneurons was sustained as long as the rat ran continuously in the wheel. Furthermore, the discharge frequency of pyramidal cells and interneurons increased with increasing running velocity, even though the frequency of hippocampal theta waves remained constant. The discharge frequency of some `wheel-related' pyramidal cells could increase more than 10-fold between 10 and 100 cm/s, whereas the firing rate of `non-wheel' cells remained constantly low. We hypothesize that: (i) a necessary condition for place-specific discharge of hippocampal pyramidal cells is the presence of theta oscillation; and (ii) relevant stimuli can tonically and selectively activate hippocampal pyramidal cells as long as theta activity is present."}],"citation":{"ieee":"A. Czurkó, H. Hirase, J. L. Csicsvari, and G. Buzsáki, “Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel,’” European Journal of Neuroscience, vol. 11, no. 1. Wiley-Blackwell, pp. 344–352, 1999.","apa":"Czurkó, A., Hirase, H., Csicsvari, J. L., & Buzsáki, G. (1999). Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00446.x","chicago":"Czurkó, András, Hajima Hirase, Jozsef L Csicsvari, and György Buzsáki. “Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00446.x.","mla":"Czurkó, András, et al. “Sustained Activation of Hippocampal Pyramidal Cells by ‘space Clamping’’ in a Running Wheel.’” European Journal of Neuroscience, vol. 11, no. 1, Wiley-Blackwell, 1999, pp. 344–52, doi:10.1046/j.1460-9568.1999.00446.x.","ama":"Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel.’ European Journal of Neuroscience. 1999;11(1):344-352. doi:10.1046/j.1460-9568.1999.00446.x","ista":"Czurkó A, Hirase H, Csicsvari JL, Buzsáki G. 1999. Sustained activation of hippocampal pyramidal cells by ‘space clamping’’ in a running wheel’. European Journal of Neuroscience. 11(1), 344–352.","short":"A. Czurkó, H. Hirase, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience 11 (1999) 344–352."},"publication_status":"published","date_created":"2018-12-11T12:03:45Z","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Wiley-Blackwell","date_published":"1999-01-01T00:00:00Z","article_type":"original","month":"01","page":"344 - 352","publication":"European Journal of Neuroscience","issue":"1","status":"public","intvolume":" 11","type":"journal_article","day":"01"},{"author":[{"full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hirase, Hajima","last_name":"Hirase","first_name":"Hajima"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"first_name":"Akira","last_name":"Mamiya","full_name":"Mamiya, Akira"},{"first_name":"György","last_name":"Buzsáki","full_name":"Buzsáki, György"}],"abstract":[{"lang":"eng","text":"We examined whether excitation and inhibition are balanced in hippocampal cortical networks. Extracellular field and single-unit activity were recorded by multiple tetrodes and multisite silicon probes to reveal the timing of the activity of hippocampal CAI pyramidal cells and classes of interneurons during theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and dendritic inhibition of pyramidal cells was deduced from the activity of interneurons in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively. int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population discharge of pyramidal cells during the theta cycle, respectively. SPW ripples were associated with a 2.5-fold net increase of excitation. The discharge frequency of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent” cells) during SPW suggesting that not all interneurons are innervated by pyramidal cells. Int(p) either fired together with (unimodal cells) or both before and after (bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum discharge probability of pyramidal neurons by 1-2 msec. Network state changes, as reflected by field activity, covaried with changes in the spike train dynamics of single cells and their interactions. Summed activity of parallel-recorded interneurons, but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse was true for the ripple cycles of SPWs. We suggest that network-driven excitability changes provide temporal windows of opportunity for single pyramidal cells to suppress, enable, or facilitate selective synaptic inputs."}],"citation":{"mla":"Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.","ama":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999","ista":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 19(1), 274–287.","short":"J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999) 274–287.","apa":"Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999","ieee":"J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat,” Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp. 274–287, 1999.","chicago":"Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999."},"publication_status":"published","quality_controlled":"1","oa_version":"Published Version","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994, MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and Ken Wise for supplying us with silicon probes.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","publication_identifier":{"issn":["0270-6474"]},"_id":"3524","pmid":1,"article_processing_charge":"No","oa":1,"volume":19,"date_updated":"2022-09-07T10:00:45Z","publist_id":"2860","title":"Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat","external_id":{"pmid":["9870957"]},"doi":"10.1523/JNEUROSCI.19-01-00274.1999","year":"1999","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/","open_access":"1"}],"status":"public","intvolume":" 19","type":"journal_article","day":"01","page":"274 - 287","publication":"Journal of Neuroscience","issue":"1","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Society for Neuroscience","date_published":"1999-01-01T00:00:00Z","article_type":"original","month":"01","date_created":"2018-12-11T12:03:47Z"},{"date_created":"2018-12-11T12:03:51Z","article_type":"original","date_published":"1999-12-01T00:00:00Z","month":"12","language":[{"iso":"eng"}],"publisher":"Wiley-Blackwell","scopus_import":"1","page":"4373 - 4380","issue":"12","publication":"European Journal of Neuroscience","type":"journal_article","day":"01","status":"public","intvolume":" 11","doi":"10.1046/j.1460-9568.1999.00853.x","year":"1999","title":"Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’","external_id":{"pmid":["10594664 "]},"date_updated":"2022-09-06T09:45:36Z","publist_id":"2845","volume":11,"article_processing_charge":"No","acknowledgement":"We thank M. Recce for his comments on the manuscript. This work wassupported by NIH (NS34994, MH54671), the Human Frontier ScienceProgram (H.H.), the EoÈtvoÈs State Fellowship (A.C.) and the Soros Foundation (A.C.) ","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","oa_version":"None","_id":"3539","pmid":1,"publication_identifier":{"issn":["0953-816X"]},"extern":"1","publication_status":"published","citation":{"chicago":"Hirase, Hajima, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space Clamping.’” European Journal of Neuroscience. Wiley-Blackwell, 1999. https://doi.org/10.1046/j.1460-9568.1999.00853.x.","apa":"Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’ European Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1046/j.1460-9568.1999.00853.x","ieee":"H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping,’” European Journal of Neuroscience, vol. 11, no. 12. Wiley-Blackwell, pp. 4373–4380, 1999.","short":"H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, European Journal of Neuroscience 11 (1999) 4373–4380.","ista":"Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping’. European Journal of Neuroscience. 11(12), 4373–4380.","mla":"Hirase, Hajima, et al. “Firing Rate and Theta-Phase Coding by Hippocampal Pyramidal Neurons during ‘Space Clamping.’” European Journal of Neuroscience, vol. 11, no. 12, Wiley-Blackwell, 1999, pp. 4373–80, doi:10.1046/j.1460-9568.1999.00853.x.","ama":"Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Firing rate and theta-phase coding by hippocampal pyramidal neurons during ‘space clamping.’ European Journal of Neuroscience. 1999;11(12):4373-4380. doi:10.1046/j.1460-9568.1999.00853.x"},"author":[{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"first_name":"András","full_name":"Czurkó, András","last_name":"Czurkó"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036"},{"last_name":"Buzsáki","full_name":"Buzsáki, György","first_name":"György"}],"abstract":[{"text":"In the hippocampus, spatial representation of the environment has been suggested to be coded by either the firing rate of pyramidal cell assemblies or the relative timing of the action potentials during the theta EEG cycle. Here, we used a behavioural `space clamp' method, which involved the confinement of the actively running animal in a defined position in space (running wheel) to examine how `spatial' and other inputs affect firing rate and timing of hippocampal CA1 pyramidal cells and interneurons. Nineteen per cent of the recorded CA1 pyramidal cells were selectively active while the rat was running in the wheel in a given direction ('wheel' cells). Spatial rotation of the apparatus showed that selective discharge of pyramidal cells in the wheel was under the combined influence of distal and apparatus cues. During steady running, both discharge rate and theta phase were constant. Rotation of the wheel apparatus resulted in a shift of both firing rate and preferred theta phase. The discharge frequency of `wheel' cells increased threefold (on average) with increasing running velocity. In contrast, change in running speed had relatively little effect on the theta phase-related discharge of `wheel' cells. Our findings indicate that mechanisms that regulate rate and phase of spikes are overlapping but not necessarily identical.","lang":"eng"}]},{"oa_version":"None","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","_id":"3554","page":"75 - 82","article_processing_charge":"No","publist_id":"2831","date_updated":"2022-09-06T09:35:53Z","publication":"Proceedings of the 8th International Meshing Roundtable","author":[{"first_name":"Xiangmin","full_name":"Jiao, Xiangmin","last_name":"Jiao"},{"full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Heath","full_name":"Heath, Michael","first_name":"Michael"}],"status":"public","abstract":[{"lang":"eng","text":"In computational simulation of coupled, multicomponent systems, it is frequently necessary to transfer data between meshes that may differ in resolution, structure, and discretization methodology. Typically, nodes from one mesh must be associated with elements of another mesh. In this paper, we formulate mesh association as a geometric problem and introduce two efficient mesh association algorithms. One of these algorithms requires linear time in the worst case if the meshes are well shaped and geometrically well aligned. Our formulation of the problem and our algorithms are more general than previous work and can be applied to surface meshes with curved elements."}],"type":"conference","day":"01","citation":{"chicago":"Jiao, Xiangmin, Herbert Edelsbrunner, and Michael Heath. “Mesh Association: Formulation and Algorithms.” In Proceedings of the 8th International Meshing Roundtable, 75–82. Elsevier, 1999.","ieee":"X. Jiao, H. Edelsbrunner, and M. Heath, “Mesh association: formulation and algorithms,” in Proceedings of the 8th International Meshing Roundtable, South Lake Tahoe, CA, United States of America, 1999, pp. 75–82.","apa":"Jiao, X., Edelsbrunner, H., & Heath, M. (1999). Mesh association: formulation and algorithms. In Proceedings of the 8th International Meshing Roundtable (pp. 75–82). South Lake Tahoe, CA, United States of America: Elsevier.","ista":"Jiao X, Edelsbrunner H, Heath M. 1999. Mesh association: formulation and algorithms. Proceedings of the 8th International Meshing Roundtable. IMR: International Meshing Roundtable, 75–82.","short":"X. Jiao, H. Edelsbrunner, M. Heath, in:, Proceedings of the 8th International Meshing Roundtable, Elsevier, 1999, pp. 75–82.","ama":"Jiao X, Edelsbrunner H, Heath M. Mesh association: formulation and algorithms. In: Proceedings of the 8th International Meshing Roundtable. Elsevier; 1999:75-82.","mla":"Jiao, Xiangmin, et al. “Mesh Association: Formulation and Algorithms.” Proceedings of the 8th International Meshing Roundtable, Elsevier, 1999, pp. 75–82."},"publication_status":"published","date_created":"2018-12-11T12:03:56Z","conference":{"start_date":"1999-10-10","name":"IMR: International Meshing Roundtable","end_date":"1999-10-13","location":"South Lake Tahoe, CA, United States of America"},"main_file_link":[{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.35.2959"}],"language":[{"iso":"eng"}],"title":"Mesh association: formulation and algorithms","publisher":"Elsevier","date_published":"1999-10-01T00:00:00Z","month":"10","year":"1999"},{"volume":223,"publist_id":"2814","date_updated":"2022-09-06T09:28:57Z","article_processing_charge":"No","page":"109 - 143","publication":"Advances in Discrete and Computational Geometry","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","oa_version":"None","_id":"3571","publication_identifier":{"isbn":["9780821878149"]},"extern":"1","type":"book_chapter","publication_status":"published","day":"01","citation":{"ama":"Dey T, Edelsbrunner H, Guha S. Computational topology. In: Advances in Discrete and Computational Geometry. Vol 223. American Mathematical Society; 1999:109-143.","mla":"Dey, Tamal, et al. “Computational Topology.” Advances in Discrete and Computational Geometry, vol. 223, American Mathematical Society, 1999, pp. 109–43.","ista":"Dey T, Edelsbrunner H, Guha S. 1999.Computational topology. In: Advances in Discrete and Computational Geometry. Contemporary Mathematics, vol. 223, 109–143.","short":"T. Dey, H. Edelsbrunner, S. Guha, in:, Advances in Discrete and Computational Geometry, American Mathematical Society, 1999, pp. 109–143.","ieee":"T. Dey, H. Edelsbrunner, and S. Guha, “Computational topology,” in Advances in Discrete and Computational Geometry, vol. 223, American Mathematical Society, 1999, pp. 109–143.","apa":"Dey, T., Edelsbrunner, H., & Guha, S. (1999). Computational topology. In Advances in Discrete and Computational Geometry (Vol. 223, pp. 109–143). American Mathematical Society.","chicago":"Dey, Tamal, Herbert Edelsbrunner, and Sumanta Guha. “Computational Topology.” In Advances in Discrete and Computational Geometry, 223:109–43. American Mathematical Society, 1999."},"author":[{"full_name":"Dey, Tamal","last_name":"Dey","first_name":"Tamal"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"last_name":"Guha","full_name":"Guha, Sumanta","first_name":"Sumanta"}],"status":"public","intvolume":" 223","alternative_title":["Contemporary Mathematics"],"date_created":"2018-12-11T12:04:01Z","date_published":"1999-01-01T00:00:00Z","year":"1999","month":"01","language":[{"iso":"eng"}],"publisher":"American Mathematical Society","title":"Computational topology"},{"status":"public","intvolume":" 66","type":"journal_article","day":"01","page":"23 - 45","publication":"Publications de l'Institut Mathématique","language":[{"iso":"eng"}],"publisher":"Mathematical Institute, Serbian Academy of Sciences and Arts","article_type":"original","date_published":"1999-01-01T00:00:00Z","month":"01","date_created":"2018-12-11T12:04:05Z","author":[{"full_name":"Dey, Tamal","last_name":"Dey","first_name":"Tamal"},{"first_name":"Herbert","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Sumanta","full_name":"Guha, Sumanta","last_name":"Guha"},{"last_name":"Nekhayev","full_name":"Nekhayev, Dmitry","first_name":"Dmitry"}],"abstract":[{"lang":"eng","text":"We study edge contractions in simplicial complexes and local conditions under which they preserve the topological type. The conditions are based on a generalized notion of boundary, which lends itself to defining a nested hierarchy of triangulable spaces measuring the distance to being a manifold."}],"citation":{"chicago":"Dey, Tamal, Herbert Edelsbrunner, Sumanta Guha, and Dmitry Nekhayev. “Topology Preserving Edge Contraction.” Publications de l’Institut Mathématique. Mathematical Institute, Serbian Academy of Sciences and Arts, 1999.","ieee":"T. Dey, H. Edelsbrunner, S. Guha, and D. Nekhayev, “Topology preserving edge contraction,” Publications de l’Institut Mathématique, vol. 66. Mathematical Institute, Serbian Academy of Sciences and Arts, pp. 23–45, 1999.","apa":"Dey, T., Edelsbrunner, H., Guha, S., & Nekhayev, D. (1999). Topology preserving edge contraction. Publications de l’Institut Mathématique. Mathematical Institute, Serbian Academy of Sciences and Arts.","short":"T. Dey, H. Edelsbrunner, S. Guha, D. Nekhayev, Publications de l’Institut Mathématique 66 (1999) 23–45.","ista":"Dey T, Edelsbrunner H, Guha S, Nekhayev D. 1999. Topology preserving edge contraction. Publications de l’Institut Mathématique. 66, 23–45.","ama":"Dey T, Edelsbrunner H, Guha S, Nekhayev D. Topology preserving edge contraction. Publications de l’Institut Mathématique. 1999;66:23-45.","mla":"Dey, Tamal, et al. “Topology Preserving Edge Contraction.” Publications de l’Institut Mathématique, vol. 66, Mathematical Institute, Serbian Academy of Sciences and Arts, 1999, pp. 23–45."},"publication_status":"published","quality_controlled":"1","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"The second author thanks Wolfgang Haken and Min Yan for interesting discussions and Günter Ziegler for suggesting the knot construction in the triangulation of the 3-sphere mentioned in Section 7.","extern":"1","publication_identifier":{"issn":["0350-1302"]},"_id":"3582","article_processing_charge":"No","oa":1,"date_updated":"2023-03-22T13:20:32Z","volume":66,"publist_id":"2803","title":"Topology preserving edge contraction","year":"1999","main_file_link":[{"url":"https://www.emis.de/journals/PIMB/080/3.html","open_access":"1"}]},{"day":"01","type":"journal_article","intvolume":" 74","status":"public","issue":"3","publication":"Genetical Research","page":"223 - 236","month":"12","date_published":"1999-12-01T00:00:00Z","article_type":"original","publisher":"Cambridge University Press","scopus_import":"1","language":[{"iso":"eng"}],"date_created":"2018-12-11T12:04:18Z","publication_status":"published","citation":{"short":"N.H. Barton, Genetical Research 74 (1999) 223–236.","ista":"Barton NH. 1999. Clines in polygenic traits. Genetical Research. 74(3), 223–236.","mla":"Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research, vol. 74, no. 3, Cambridge University Press, 1999, pp. 223–36, doi:10.1017/S001667239900422X.","ama":"Barton NH. Clines in polygenic traits. Genetical Research. 1999;74(3):223-236. doi:10.1017/S001667239900422X","chicago":"Barton, Nicholas H. “Clines in Polygenic Traits.” Genetical Research. Cambridge University Press, 1999. https://doi.org/10.1017/S001667239900422X.","apa":"Barton, N. H. (1999). Clines in polygenic traits. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S001667239900422X","ieee":"N. H. Barton, “Clines in polygenic traits,” Genetical Research, vol. 74, no. 3. Cambridge University Press, pp. 223–236, 1999."},"abstract":[{"lang":"eng","text":"This article outlines theoretical models of clines in additive polygenic traits, which are maintained by stabilizing selection towards a spatially varying optimum. Clines in the trait mean can be accurately predicted, given knowledge of the genetic variance. However, predicting the variance is difficult, because it depends on genetic details. Changes in genetic variance arise from changes in allele frequency, and in linkage disequilibria. Allele frequency changes dominate when selection is weak relative to recombination, and when there are a moderate number of loci. With a continuum of alleles, gene flow inflates the genetic variance in the same way as a source of mutations of small effect. The variance can be approximated by assuming a Gaussian distribution of allelic effects; with a sufficiently steep cline, this is accurate even when mutation and selection alone are better described by the 'House of Cards' approximation. With just two alleles at each locus, the phenotype changes in a similar way: the mean remains close to the optimum, while the variance changes more slowly, and over a wider region. However, there may be substantial cryptic divergence at the underlying loci. With strong selection and many loci, linkage disequilibria are the main cause of changes in genetic variance. Even for strong selection, the infinitesimal model can be closely approximated by assuming a Gaussian distribution of breeding values. Linkage disequilibria can generate a substantial increase in genetic variance, which is concentrated at sharp gradients in trait means."}],"author":[{"first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"volume":74,"publist_id":"2758","date_updated":"2022-09-06T09:10:35Z","article_processing_charge":"No","_id":"3625","pmid":1,"extern":"1","publication_identifier":{"issn":["0016-6723"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"This work was supported by the Darwin Trust of Edinburgh, and by grants MMI09726 from the BBSRC}EPSRC and GR3}11635 from the NERC. I would like to thank R. Lande and M. Slatkin for their comments on an earlier incarnation of this article, and Mark Kirkpatrick, Loeske Kruuk and Michael Turelli for their comments on this manuscript.","oa_version":"None","quality_controlled":"1","doi":"10.1017/S001667239900422X","year":"1999","title":"Clines in polygenic traits","external_id":{"pmid":["10689800 "]}},{"volume":153,"date_updated":"2022-09-06T09:06:02Z","publist_id":"2757","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","oa_version":"None","_id":"3626","pmid":1,"publication_identifier":{"issn":["0016-6731"]},"extern":"1","publication_status":"published","citation":{"apa":"Kruuk, L., Baird, S., Gale, K., & Barton, N. H. (1999). A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/153.4.1959","ieee":"L. Kruuk, S. Baird, K. Gale, and N. H. Barton, “A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids,” Genetics, vol. 153, no. 4. Genetics Society of America, pp. 1959–1971, 1999.","chicago":"Kruuk, Loeske, Stuart Baird, Katherine Gale, and Nicholas H Barton. “A Comparison of Multilocus Clines Maintained by Environmental Adaptation or by Selection against Hybrids.” Genetics. Genetics Society of America, 1999. https://doi.org/10.1093/genetics/153.4.1959.","ama":"Kruuk L, Baird S, Gale K, Barton NH. A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids. Genetics. 1999;153(4):1959-1971. doi:10.1093/genetics/153.4.1959","mla":"Kruuk, Loeske, et al. “A Comparison of Multilocus Clines Maintained by Environmental Adaptation or by Selection against Hybrids.” Genetics, vol. 153, no. 4, Genetics Society of America, 1999, pp. 1959–71, doi:10.1093/genetics/153.4.1959.","ista":"Kruuk L, Baird S, Gale K, Barton NH. 1999. A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids. Genetics. 153(4), 1959–1971.","short":"L. Kruuk, S. Baird, K. Gale, N.H. Barton, Genetics 153 (1999) 1959–1971."},"author":[{"first_name":"Loeske","last_name":"Kruuk","full_name":"Kruuk, Loeske"},{"first_name":"Stuart","full_name":"Baird, Stuart","last_name":"Baird"},{"first_name":"Katherine","full_name":"Gale, Katherine","last_name":"Gale"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"abstract":[{"text":"There has recently been considerable debate over the relative importance of selection against hybrids ("endogenous" selection) vs. adaptation to different environments ("exogenous") in maintaining stable hybrid zones and hence in speciation. Single-locus models of endogenous and exogenous viability selection generate clines of similar shape, but the comparison has not been extended to multilocus systems, which are both quantitatively and qualitatively very different from the single-locus case. Here we develop an analytical multilocus model of differential adaptation across an environmental transition and compare it to previous heterozygote disadvantage models. We show that the shape of clines generated by exogenous selection is indistinguishable from that generated by endogenous selection. A stochastic simulation model is used to test the robustness of the analytical description to the effects of drift and strong selection, and confirms the prediction that pairwise linkage disequilibria are predominantly generated by migration. However, although analytical predictions for the width of clines maintained by heterozygote disadvantage fit well with the simulation results, those for environmental adaptation are consistently too narrow; reasons for the discrepancy are discussed. There is a smooth transition between a system in which a set of loci effectively act independently of each other and one in which they act as a single nonrecombining unit.","lang":"eng"}],"year":"1999","doi":"10.1093/genetics/153.4.1959","title":"A comparison of multilocus clines maintained by environmental adaptation or by selection against hybrids","external_id":{"pmid":["10581299"]},"page":"1959 - 1971","issue":"4","publication":"Genetics","type":"journal_article","day":"01","status":"public","intvolume":" 153","date_created":"2018-12-11T12:04:19Z","date_published":"1999-12-01T00:00:00Z","article_type":"original","month":"12","language":[{"iso":"eng"}],"publisher":"Genetics Society of America","scopus_import":"1"}]