[{"language":[{"iso":"eng"}],"doi":"10.1016/S0168-0102(00)00095-X","day":"01","type":"journal_article","date_updated":"2023-05-03T10:47:06Z","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","publication_identifier":{"issn":["0168-0102"]},"scopus_import":"1","page":"327 - 334","date_published":"2000-04-01T00:00:00Z","external_id":{"pmid":["10771111"]},"publication_status":"published","abstract":[{"lang":"eng","text":"The synaptic relationship between substance P (SP) and its receptor, i.e. neurokinin-1 receptor (NK1R), was examined in the superficial laminae of the caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) of the rat. For confocal laser-scanning microscopy, double-immunofluorescence histochemistry for NK1 and SP was performed. In electron microscopic double-immunolabeling study, immunoreactivity for NK1R was detected with the silver-intensified gold method, while immunoreactivity for SP was detected with peroxidase immunohistochemistry. SP-immunoreactive axon terminals were observed to be in synaptic (mostly asymmetric) contact with NK1R-immunoreactive neuronal profiles in lamina I and lamina IIo. Although some SP-immunoreactive axon terminals were in synaptic contact with NK1R-immunoreactive sites of plasma membranes, NK1R-immunoreactivity was observed at both synaptic and non-synaptic sites of plasma membrane. Thus, SP released from axon terminals might not only act on NK1Rs facing the SP-containing axon terminals, but also diffuse in the extracellular fluid for distances larger than the synaptic cleft to act on NK1Rs at some distances from the synaptic sites. "}],"_id":"2600","title":"The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat","publication":"Neuroscience Research","pmid":1,"year":"2000","quality_controlled":"1","extern":"1","author":[{"last_name":"Li","first_name":"Jin","full_name":"Li, Jin"},{"full_name":"Wang, Dan","first_name":"Dan","last_name":"Wang"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Nomura","first_name":"Sakashi","full_name":"Nomura, Sakashi"},{"first_name":"Noboru","last_name":"Mizuno","full_name":"Mizuno, Noboru"}],"citation":{"ama":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 2000;36(4):327-334. doi:10.1016/S0168-0102(00)00095-X","ieee":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, and N. Mizuno, “The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat,” Neuroscience Research, vol. 36, no. 4. Elsevier, pp. 327–334, 2000.","short":"J. Li, D. Wang, T. Kaneko, R. Shigemoto, S. Nomura, N. Mizuno, Neuroscience Research 36 (2000) 327–334.","chicago":"Li, Jin, Dan Wang, Takeshi Kaneko, Ryuichi Shigemoto, Sakashi Nomura, and Noboru Mizuno. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research. Elsevier, 2000. https://doi.org/10.1016/S0168-0102(00)00095-X.","ista":"Li J, Wang D, Kaneko T, Shigemoto R, Nomura S, Mizuno N. 2000. The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. 36(4), 327–334.","mla":"Li, Jin, et al. “The Relationship between Neurokinin-1 Receptor and Substance P in the Medullary Dorsal Horn: A Light and Electron Microscopic Immunohistochemical Study in the Rat.” Neuroscience Research, vol. 36, no. 4, Elsevier, 2000, pp. 327–34, doi:10.1016/S0168-0102(00)00095-X.","apa":"Li, J., Wang, D., Kaneko, T., Shigemoto, R., Nomura, S., & Mizuno, N. (2000). The relationship between neurokinin-1 receptor and substance P in the medullary dorsal horn: A light and electron microscopic immunohistochemical study in the rat. Neuroscience Research. Elsevier. https://doi.org/10.1016/S0168-0102(00)00095-X"},"status":"public","date_created":"2018-12-11T11:58:36Z","month":"04","publist_id":"4298","intvolume":" 36","article_type":"original","publisher":"Elsevier","issue":"4","volume":36},{"language":[{"iso":"eng"}],"doi":"10.1126/science.288.5472.1832","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","oa_version":"None","date_updated":"2023-05-03T09:53:38Z","type":"journal_article","day":"09","scopus_import":"1","publication_identifier":{"issn":["0036-8075"]},"external_id":{"pmid":["10846166 "]},"date_published":"2000-06-09T00:00:00Z","page":"1832 - 1835","pmid":1,"title":"mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination","publication":"Science","_id":"2601","abstract":[{"text":"Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.","lang":"eng"}],"publication_status":"published","citation":{"mla":"Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:10.1126/science.288.5472.1832.","apa":"Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832","ista":"Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.","short":"T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.","chicago":"Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” Science. American Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.288.5472.1832.","ieee":"T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” Science, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000.","ama":"Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832"},"extern":"1","quality_controlled":"1","author":[{"last_name":"Ichise","first_name":"Taeko","full_name":"Ichise, Taeko"},{"full_name":"Kano, Masanobu","last_name":"Kano","first_name":"Masanobu"},{"full_name":"Hashimoto, Kouichi","first_name":"Kouichi","last_name":"Hashimoto"},{"full_name":"Yanagihara, Dai","last_name":"Yanagihara","first_name":"Dai"},{"full_name":"Nakao, Kazuki","first_name":"Kazuki","last_name":"Nakao"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Katsuki","first_name":"Motoya","full_name":"Katsuki, Motoya"},{"full_name":"Aiba, Atsu","first_name":"Atsu","last_name":"Aiba"}],"year":"2000","intvolume":" 288","publist_id":"4297","month":"06","date_created":"2018-12-11T11:58:36Z","status":"public","volume":288,"issue":"5472","publisher":"American Association for the Advancement of Science","article_type":"original"},{"publication_status":"published","abstract":[{"lang":"eng","text":"Although presynaptic localization of mGluR7 is well established, the mechanism by which the receptor may control Ca2+ channels in neurons is still unknown. We show here that cultured cerebellar granule cells express native metabotropic glutamate receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was also expressed in cell bodies. This allowed us to study the effect of the transfected receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel subunit, but was abolished by quenching βγ subunits with specific intracellular peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action of mGluR7, suggesting that both G-protein βγ and αo subunits were required to mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory action of mGluR7, suggesting that a coincident activation of PLC by the G-protein βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC) abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release was required for PKC-dependent inhibition of the Ca2+ channels. Possible control of synaptic transmission by the present mechanisms is discussed."}],"oa":1,"_id":"2602","publication":"Journal of Neuroscience","title":"Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons","pmid":1,"year":"2000","extern":"1","quality_controlled":"1","author":[{"first_name":"Julie","last_name":"Perroy","full_name":"Perroy, Julie"},{"last_name":"Prezèau","first_name":"Laurent","full_name":"Prezèau, Laurent"},{"last_name":"De Waard","first_name":"Michel","full_name":"De Waard, Michel"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"last_name":"Bockaërt","first_name":"Joël","full_name":"Bockaërt, Joël"},{"first_name":"Laurent","last_name":"Fagni","full_name":"Fagni, Laurent"}],"citation":{"mla":"Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000, pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.","apa":"Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni, L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000","ista":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21), 7896–7904.","short":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni, Journal of Neuroscience 20 (2000) 7896–7904.","chicago":"Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.","ieee":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni, “Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons,” Journal of Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.","ama":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000"},"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/","open_access":"1"}],"status":"public","date_created":"2018-12-11T11:58:37Z","month":"11","publist_id":"4296","intvolume":" 20","publisher":"Society for Neuroscience","article_type":"original","volume":20,"issue":"21","acknowledgement":"This work was supported by Centre National de la Recherche Scientifique and grants from Association Française contre les Myopathies, Fondation pour la Recherche Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J. P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J. Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France) for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal antibody.","language":[{"iso":"eng"}],"doi":"10.1523/JNEUROSCI.20-21-07896.2000","day":"01","type":"journal_article","date_updated":"2023-05-03T09:48:17Z","oa_version":"Published Version","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","publication_identifier":{"issn":["0270-6474"]},"scopus_import":"1","page":"7896 - 7904","date_published":"2000-11-01T00:00:00Z","external_id":{"pmid":["11050109"]}},{"issue":"2","volume":28,"publisher":"Elsevier","article_type":"original","publist_id":"4295","intvolume":" 28","status":"public","month":"11","date_created":"2018-12-11T11:58:37Z","author":[{"full_name":"Boudin, Hélène","last_name":"Boudin","first_name":"Hélène"},{"full_name":"Doan, Andrew","last_name":"Doan","first_name":"Andrew"},{"full_name":"Xia, Jun","first_name":"Jun","last_name":"Xia"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi"},{"last_name":"Huganir","first_name":"Richard","full_name":"Huganir, Richard"},{"full_name":"Worley, Paul","last_name":"Worley","first_name":"Paul"},{"full_name":"Craig, Ann","first_name":"Ann","last_name":"Craig"}],"extern":"1","quality_controlled":"1","citation":{"mla":"Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97, doi:10.1016/S0896-6273(00)00127-6.","apa":"Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., & Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6","ista":"Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 28(2), 485–497.","chicago":"Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir, Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6.","short":"H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig, Neuron 28 (2000) 485–497.","ama":"Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6","ieee":"H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497, 2000."},"year":"2000","_id":"2603","pmid":1,"publication":"Neuron","title":"Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site","abstract":[{"lang":"eng","text":"Aggregation of neurotransmitter receptors at pre- and postsynaptic structures is crucial for efficient neuronal communication. In contrast to the wealth of information about postsynaptic specializations, little is known about the molecular organization of presynaptic membrane proteins. We show here that the metabotropic glutamate receptor mGluR7a, which localizes specifically to presynaptic active zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous systems induces coclustering dependent upon the extreme C terminus of mGluR7a and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not cluster. These results suggest that PICK1 is a component of the presynaptic machinery involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission."}],"publication_status":"published","page":"485 - 497","external_id":{"pmid":["11144358"]},"date_published":"2000-11-01T00:00:00Z","scopus_import":"1","publication_identifier":{"issn":["0896-6273"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"01","oa_version":"None","type":"journal_article","date_updated":"2023-05-03T09:41:55Z","doi":"10.1016/S0896-6273(00)00127-6","language":[{"iso":"eng"}],"acknowledgement":"We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P. J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work was supported by the Pew Chari-table Trust and National Institutes of Health grants NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship from IPSEN Foundation (H. B.). "},{"month":"01","date_created":"2018-12-11T11:59:12Z","status":"public","intvolume":" 16","publist_id":"4186","publisher":"American Mathematical Society","volume":16,"abstract":[{"lang":"eng","text":"In this paper we describe an intrinsically geometric way of producing magnetic fields on §3 and $\\R^3$ for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau (Commun. Math. Phys. 104 (1986) 283-290)."}],"publication_status":"published","publication":"Differential Equations and Mathematical Physics","title":"The kernel of Dirac operators on S3 and R3","_id":"2710","year":"2000","citation":{"mla":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–19, doi:10.1090/amsip/016.","apa":"Erdös, L. (2000). The kernel of Dirac operators on S3 and R3. In Differential Equations and Mathematical Physics (Vol. 16, pp. 111–119). American Mathematical Society. https://doi.org/10.1090/amsip/016","chicago":"Erdös, László. “The Kernel of Dirac Operators on S3 and R3.” In Differential Equations and Mathematical Physics, 16:111–19. American Mathematical Society, 2000. https://doi.org/10.1090/amsip/016.","short":"L. Erdös, in:, Differential Equations and Mathematical Physics, American Mathematical Society, 2000, pp. 111–119.","ista":"Erdös L. 2000.The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. AMS/IP Studies in Advanced Mathematics, vol. 16, 111–119.","ieee":"L. Erdös, “The kernel of Dirac operators on S3 and R3,” in Differential Equations and Mathematical Physics, vol. 16, American Mathematical Society, 2000, pp. 111–119.","ama":"Erdös L. The kernel of Dirac operators on S3 and R3. In: Differential Equations and Mathematical Physics. Vol 16. American Mathematical Society; 2000:111-119. doi:10.1090/amsip/016"},"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös"}],"quality_controlled":"1","extern":"1","arxiv":1,"alternative_title":["AMS/IP Studies in Advanced Mathematics"],"publication_identifier":{"isbn":["9780821821572"]},"external_id":{"arxiv":["math-ph/0001036"]},"date_published":"2000-01-01T00:00:00Z","page":"111 - 119","acknowledgement":"L. Erdös was supported by the N.S.F. grant DMS-9970323. J. P. Solovej was supported in parts by the EU TMR-grant FMRX-CT 96-0001 by MaPhySto — Centre for Mathematical Physics and Stochastics, funded by a grant from The Danish National Research Foundation and by a grant from the Danish Natural Science Research Council.","language":[{"iso":"eng"}],"doi":"10.1090/amsip/016","oa_version":"Preprint","date_updated":"2023-05-03T09:37:03Z","type":"book_chapter","day":"01","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No"},{"date_published":"2000-06-01T00:00:00Z","external_id":{"arxiv":["math-ph/9901020"]},"page":"667 - 735","publication_identifier":{"issn":["0010-3640"]},"scopus_import":"1","arxiv":1,"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","date_updated":"2023-05-03T09:09:04Z","type":"journal_article","oa_version":"Preprint","day":"01","language":[{"iso":"eng"}],"doi":"10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5","acknowledgement":"Partially supported by U.S. National Science Foundation grants DMS-9403462, 9703752. We would like to thank H. Spohn for his several comments and discussions on this project. Part of this work was done during the time when L. E. visited the Erwin Schrödinger Institute in Vienna and when both authors visited the Center of Theoretical Sciences in Taiwan. We thank them for the hospitality and the support of this work.","volume":53,"issue":"6","article_type":"original","publisher":"Wiley-Blackwell","intvolume":" 53","publist_id":"4161","date_created":"2018-12-11T11:59:18Z","month":"06","status":"public","citation":{"short":"L. Erdös, H. Yau, Communications on Pure and Applied Mathematics 53 (2000) 667–735.","chicago":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling Limit of a Random Schrödinger Equation.” Communications on Pure and Applied Mathematics. Wiley-Blackwell, 2000. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5.","ista":"Erdös L, Yau H. 2000. Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. 53(6), 667–735.","ieee":"L. Erdös and H. Yau, “Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation,” Communications on Pure and Applied Mathematics, vol. 53, no. 6. Wiley-Blackwell, pp. 667–735, 2000.","ama":"Erdös L, Yau H. Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. 2000;53(6):667-735. doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5","apa":"Erdös, L., & Yau, H. (2000). Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation. Communications on Pure and Applied Mathematics. Wiley-Blackwell. https://doi.org/10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5","mla":"Erdös, László, and Horng Yau. “Linear Boltzmann Equation as the Weak Coupling Limit of a Random Schrödinger Equation.” Communications on Pure and Applied Mathematics, vol. 53, no. 6, Wiley-Blackwell, 2000, pp. 667–735, doi:10.1002/(SICI)1097-0312(200006)53:6<667::AID-CPA1>3.0.CO;2-5."},"author":[{"first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Yau","first_name":"Horng","full_name":"Yau, Horng"}],"extern":"1","quality_controlled":"1","year":"2000","title":"Linear Boltzmann equation as the weak coupling limit of a random Schrödinger equation","publication":"Communications on Pure and Applied Mathematics","_id":"2731","publication_status":"published","abstract":[{"lang":"eng","text":"We study the time evolution of a quantum particle in a Gaussian random environment. We show that in the weak coupling limit the Wigner distribution of the wave function converges to a solution of a linear Boltzmann equation globally in time. The Boltzmann collision kernel is given by the Born approximation of the quantum differential scattering cross section."}]},{"abstract":[{"text":"We consider a quantum particle moving in a harmonic exterior potential and linearly coupled to a heat bath of quantum oscillators. Caldeira and Leggett derived the Fokker Planck equation with friction for the Wigner distribution of the particle in the large-temperature limit: however, their (nonrigorous) derivation was not free of criticism, especially since the limiting equation is not of Lindblad form. In this paper we recover the correct form of their result in a rigorous way. We also point out that the source of the diffusion is physically restrictive under this scaling. We investigate the model at a fixed temperature and in the large-time limit, where the origin of the diffusion is a cumulative effect of many resonant collisions. We obtain a heat equation with a friction term for the radial process in phase space and we prove the Einstein relation in this case.","lang":"eng"}],"publication_status":"published","_id":"2732","publication":"Journal of Statistical Physics","title":"Fokker-Planck equations as scaling limits of reversible quantum systems","year":"2000","extern":"1","author":[{"last_name":"Castella","first_name":"François","full_name":"Castella, François"},{"orcid":"0000-0001-5366-9603","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös"},{"full_name":"Frommlet, Florian","first_name":"Florian","last_name":"Frommlet"},{"full_name":"Markowich, Peter","first_name":"Peter","last_name":"Markowich"}],"quality_controlled":"1","citation":{"ama":"Castella F, Erdös L, Frommlet F, Markowich P. Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. 2000;100(3-4):543-601. doi:10.1023/A:1018667323830","ieee":"F. Castella, L. Erdös, F. Frommlet, and P. Markowich, “Fokker-Planck equations as scaling limits of reversible quantum systems,” Journal of Statistical Physics, vol. 100, no. 3–4. Springer, pp. 543–601, 2000.","ista":"Castella F, Erdös L, Frommlet F, Markowich P. 2000. Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. 100(3–4), 543–601.","chicago":"Castella, François, László Erdös, Florian Frommlet, and Peter Markowich. “Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal of Statistical Physics. Springer, 2000. https://doi.org/10.1023/A:1018667323830.","short":"F. Castella, L. Erdös, F. Frommlet, P. Markowich, Journal of Statistical Physics 100 (2000) 543–601.","apa":"Castella, F., Erdös, L., Frommlet, F., & Markowich, P. (2000). Fokker-Planck equations as scaling limits of reversible quantum systems. Journal of Statistical Physics. Springer. https://doi.org/10.1023/A:1018667323830","mla":"Castella, François, et al. “Fokker-Planck Equations as Scaling Limits of Reversible Quantum Systems.” Journal of Statistical Physics, vol. 100, no. 3–4, Springer, 2000, pp. 543–601, doi:10.1023/A:1018667323830."},"status":"public","month":"01","date_created":"2018-12-11T11:59:18Z","publist_id":"4160","intvolume":" 100","publisher":"Springer","article_type":"original","issue":"3-4","volume":100,"acknowledgement":"The authors are indebted to H. Spohn for discussions. F.C. and L.E. were partially supported by the Erwin Schrödinger Institute in Vienna (Austria) during their visit, and they thank this institution for its hospitality. This work was supported by the TMR-Network ``Asymptotic Methods in Kinetic Theory'' number ERB FMBX CT97 0157 (F.C., F.F., and P.A.M.) and by NSF Grant DMS-9970323 (L.E.).","doi":"10.1023/A:1018667323830","language":[{"iso":"eng"}],"day":"01","oa_version":"None","date_updated":"2023-05-03T09:02:11Z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","publication_identifier":{"issn":["0022-4715"]},"page":"543 - 601","date_published":"2000-01-01T00:00:00Z"},{"doi":"10.5802/aif.1777","language":[{"iso":"eng"}],"oa_version":"None","date_updated":"2023-05-03T08:56:17Z","type":"journal_article","day":"01","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","scopus_import":"1","publication_identifier":{"issn":["0373-0956"]},"date_published":"2000-01-01T00:00:00Z","page":"891 - 907","abstract":[{"lang":"eng","text":"The Li-Yau semiclassical lower bound for the sum of the first N eigenvalues of the Dirichlet–Laplacian is extended to Dirichlet–Laplacians with constant magnetic fields. Our method involves a new diamagnetic inequality for constant magnetic fields."}],"publication_status":"published","title":"Diamagnetic behavior of sums Dirichlet eigenvalues","publication":"Annales de l'Institut Fourier","_id":"2733","year":"2000","citation":{"ama":"Erdös L, Loss M, Vougalter V. Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. 2000;50(3):891-907. doi:10.5802/aif.1777","ieee":"L. Erdös, M. Loss, and V. Vougalter, “Diamagnetic behavior of sums Dirichlet eigenvalues,” Annales de l’Institut Fourier, vol. 50, no. 3. Association des Annales de l’Institut Fourier, pp. 891–907, 2000.","chicago":"Erdös, László, Michael Loss, and Vitali Vougalter. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier, 2000. https://doi.org/10.5802/aif.1777.","short":"L. Erdös, M. Loss, V. Vougalter, Annales de l’Institut Fourier 50 (2000) 891–907.","ista":"Erdös L, Loss M, Vougalter V. 2000. Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. 50(3), 891–907.","apa":"Erdös, L., Loss, M., & Vougalter, V. (2000). Diamagnetic behavior of sums Dirichlet eigenvalues. Annales de l’Institut Fourier. Association des Annales de l’Institut Fourier. https://doi.org/10.5802/aif.1777","mla":"Erdös, László, et al. “Diamagnetic Behavior of Sums Dirichlet Eigenvalues.” Annales de l’Institut Fourier, vol. 50, no. 3, Association des Annales de l’Institut Fourier, 2000, pp. 891–907, doi:10.5802/aif.1777."},"author":[{"first_name":"László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","orcid":"0000-0001-5366-9603"},{"last_name":"Loss","first_name":"Michael","full_name":"Loss, Michael"},{"first_name":"Vitali","last_name":"Vougalter","full_name":"Vougalter, Vitali"}],"extern":"1","quality_controlled":"1","month":"01","date_created":"2018-12-11T11:59:19Z","status":"public","intvolume":" 50","publist_id":"4159","publisher":"Association des Annales de l'Institut Fourier","article_type":"original","volume":50,"issue":"3"},{"volume":275,"issue":"23","article_type":"original","publisher":"American Society for Biochemistry and Molecular Biology","intvolume":" 275","publist_id":"3546","month":"06","date_created":"2018-12-11T12:01:40Z","status":"public","citation":{"ieee":"J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion,” Journal of Biological Chemistry, vol. 275, no. 23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893, 2000.","ama":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893. doi:10.1074/jbc.M000032200 ","short":"J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological Chemistry 275 (2000) 17886–17893.","chicago":"Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .","ista":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.","mla":"Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .","apa":"Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000). Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 "},"main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub","open_access":"1"}],"quality_controlled":"1","author":[{"last_name":"Hwang","first_name":"Jae","full_name":"Hwang, Jae"},{"id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8323-8353","full_name":"Siekhaus, Daria E","last_name":"Siekhaus","first_name":"Daria E"},{"full_name":"Fuller, Robert","last_name":"Fuller","first_name":"Robert"},{"last_name":"Taghert","first_name":"Paul","full_name":"Taghert, Paul"},{"full_name":"Lindberg, Iris","last_name":"Lindberg","first_name":"Iris"}],"extern":"1","year":"2000","pmid":1,"publication":"Journal of Biological Chemistry","title":"Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion","_id":"3149","oa":1,"abstract":[{"lang":"eng","text":"The prohormone convertases (PCs) are an evolutionarily ancient group of proteases required for the maturation of neuropeptide and peptide hormone precursors. In Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado), is required for normal hatching behavior, and immunoblotting data indicate that flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires 7B2, a helper protein for productive maturation, we searched the fly data base for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and rat 7B2 were used as controls. Although active mPC2 was detected in medium in the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was synthesized but not secreted from HEK-293 cells. However, when dPC2 and either d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive dPC2 was secreted into the medium, coincident with the appearance of PC2 activity. Expression and secretion of dPC2 enzyme activity thus appears to require insect cell-specific posttranslational processing events. The significant differences in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required for secretion of dPC2 and zymogen conversion occurring intracellularly in the case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific requirements for maturation and secretion that can be met only in insect cells."}],"publication_status":"published","external_id":{"pmid":["10749852"]},"date_published":"2000-06-09T00:00:00Z","page":"17886 - 17893","scopus_import":"1","publication_identifier":{"issn":["0021-9258"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","oa_version":"Published Version","type":"journal_article","date_updated":"2023-05-03T08:47:13Z","day":"09","language":[{"iso":"eng"}],"doi":"10.1074/jbc.M000032200 ","acknowledgement":"This work was supported by National Institutes of Health Grants DK49703 (to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans PC2 expression vector, and Joelle Finley for assistance with cell culture."},{"acknowledgement":"This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B) to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger, F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically reading this manuscript. We also thank A. Blomenkamp for technical assistance.","language":[{"iso":"eng"}],"doi":"10.1523/JNEUROSCI.20-15-05594.2000","day":"01","oa_version":"Published Version","type":"journal_article","date_updated":"2023-05-03T08:18:39Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","publication_identifier":{"issn":["0270-6474"]},"page":"5594 - 5607","external_id":{"pmid":["10908596"]},"date_published":"2000-08-01T00:00:00Z","abstract":[{"lang":"eng","text":"We have examined factors that determine the strength and dynamics of GABAergic synapses between interneurons [dentate gyrus basket cells (BCs)] and principal neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular Cl− concentration showed a fast rise and a biexponential decay, with mean time constants of 2 and 9 msec. The mean quantal conductance change, determined directly at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis of IPSC peak amplitudes and numbers of failures by multiple probability compound binomial analysis indicated that synaptic transmission at the BC–GC synapse involves three to seven release sites, each of which releases transmitter with high probability (∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression (PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery from depression occurred with a time constant of 2 sec. Paired-pulse depression was mainly presynaptic in origin but appeared to be independent of previous release. Synaptic transmission at the BC–GC synapse showed frequency-dependent depression, with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials. The relative stability of transmission at the BC–GC synapse is consistent with a model in which an activity-dependent gating mechanism reduces release probability and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus several mechanisms converge on the generation of powerful and sustained transmission at interneuron–principal neuron synapses in hippocampal circuits."}],"publication_status":"published","_id":"3489","oa":1,"pmid":1,"title":"Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse","publication":"Journal of Neuroscience","year":"2000","quality_controlled":"1","extern":"1","author":[{"last_name":"Kraushaar","first_name":"Udo","full_name":"Kraushaar, Udo"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","first_name":"Peter M"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/"}],"citation":{"ista":"Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 20(15), 5594–5607.","chicago":"Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.","short":"U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.","ieee":"U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience, vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.","ama":"Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000","apa":"Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000","mla":"Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607, doi:10.1523/JNEUROSCI.20-15-05594.2000."},"status":"public","month":"08","date_created":"2018-12-11T12:03:36Z","publist_id":"2898","intvolume":" 20","publisher":"Society for Neuroscience","article_type":"original","volume":20,"issue":"15"},{"page":"8290 - 8297","external_id":{"pmid":["11069935"]},"date_published":"2000-11-15T00:00:00Z","publication_identifier":{"issn":["0270-6474"]},"day":"15","oa_version":"Published Version","type":"journal_article","date_updated":"2023-05-03T08:02:52Z","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"This work was supported by a grant from the Deutsche Forschungsgemeinschaft Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation (J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically reading this manuscript and A. Blomenkamp for technical assistance.","language":[{"iso":"eng"}],"doi":"10.1523/JNEUROSCI.20-22-08290.2000","article_type":"original","publisher":"Society for Neuroscience","volume":20,"issue":"22","status":"public","month":"11","date_created":"2018-12-11T12:03:36Z","publist_id":"2897","intvolume":" 20","year":"2000","extern":"1","author":[{"first_name":"Claus","last_name":"Normann","full_name":"Normann, Claus"},{"last_name":"Peckys","first_name":"Diana","full_name":"Peckys, Diana"},{"first_name":"Christian","last_name":"Schulze","full_name":"Schulze, Christian"},{"last_name":"Walden","first_name":"Jörg","full_name":"Walden, Jörg"},{"first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Bischofberger, Joseph","first_name":"Joseph","last_name":"Bischofberger"}],"quality_controlled":"1","citation":{"chicago":"Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas, and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.","short":"C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger, Journal of Neuroscience 20 (2000) 8290–8297.","ista":"Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000. Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.","ieee":"C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger, “Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society for Neuroscience, pp. 8290–8297, 2000.","ama":"Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000","mla":"Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience, vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000.","apa":"Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger, J. (2000). Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000"},"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/","open_access":"1"}],"abstract":[{"text":"Long-term depression (LTD) is a form of synaptic plasticity that can be induced either by low-frequency stimulation of presynaptic fibers or in an associative manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices. Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant to the application of D-AP-5, indicating that it is independent of NMDA receptors. In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine, indicating the involvement of metabotropic glutamate receptors. Furthermore, associative LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin GVIA, a selective N-type channel blocker, abolished the induction of associative LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist, inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting presynaptic transmitter release. OH-DPAT also inhibited the induction of associative LTD, suggesting that the involvement of N-type channels makes synaptic plasticity accessible to modulation by neurotransmitters. Thus, the modulation of N-type Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal neurons.","lang":"eng"}],"publication_status":"published","_id":"3490","oa":1,"pmid":1,"publication":"Journal of Neuroscience","title":"Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels"},{"language":[{"iso":"eng"}],"doi":"10.1126/science.287.5451.295","day":"14","oa_version":"None","date_updated":"2023-05-03T07:55:32Z","type":"journal_article","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","scopus_import":"1","publication_identifier":{"issn":["0036-8075"]},"page":"295 - 300","external_id":{"pmid":["10634782"]},"date_published":"2000-01-14T00:00:00Z","abstract":[{"lang":"eng","text":"Fast and reliable activation of inhibitory interneurons is critical for the stability of cortical neuronal networks. Active conductances in dendrites may facilitate interneuron activation, but direct experimental evidence was unavailable. Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous recordings from dendrites and somata suggested that action potential initiation occurs preferentially in the axon with long threshold stimuli, but can be shifted to somatodendritic sites when brief stimuli are applied. After initiation, action potentials propagate over the somatodendritic domain with constant amplitude, high velocity, and reliability, even during high-frequency trains."}],"publication_status":"published","_id":"3491","pmid":1,"title":"Distal initiation and active propagation of action potentials in interneuron dendrites","publication":"Science","year":"2000","extern":"1","quality_controlled":"1","author":[{"full_name":"Martina, Marco","last_name":"Martina","first_name":"Marco"},{"first_name":"Imre","last_name":"Vida","full_name":"Vida, Imre"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"citation":{"ieee":"M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation of action potentials in interneuron dendrites,” Science, vol. 287, no. 5451. American Association for the Advancement of Science, pp. 295–300, 2000.","ama":"Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action potentials in interneuron dendrites. Science. 2000;287(5451):295-300. doi:10.1126/science.287.5451.295","ista":"Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation of action potentials in interneuron dendrites. Science. 287(5451), 295–300.","short":"M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.","chicago":"Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” Science. American Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.287.5451.295.","mla":"Martina, Marco, et al. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” Science, vol. 287, no. 5451, American Association for the Advancement of Science, 2000, pp. 295–300, doi:10.1126/science.287.5451.295.","apa":"Martina, M., Vida, I., & Jonas, P. M. (2000). Distal initiation and active propagation of action potentials in interneuron dendrites. Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.287.5451.295"},"status":"public","month":"01","date_created":"2018-12-11T12:03:36Z","publist_id":"2896","intvolume":" 287","article_type":"original","publisher":"American Association for the Advancement of Science","issue":"5451","volume":287},{"doi":"10.1016/S0896-6273(00)00164-1","language":[{"iso":"eng"}],"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","day":"01","oa_version":"None","date_updated":"2023-05-02T14:34:37Z","type":"journal_article","publication_identifier":{"issn":["0896-6273"]},"page":"927 - 939","external_id":{"pmid":["11163277"]},"date_published":"2000-12-01T00:00:00Z","_id":"3492","pmid":1,"publication":"Neuron","title":"Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons","abstract":[{"lang":"eng","text":"Analysis of presynaptic determinants of synaptic strength has been difficult at cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices. The presynaptic action potential is very short during low-frequency stimulation but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly, suggesting that cumulative K+ channel inactivation mediates activity-dependent spike broadening. Prolongation of the presynaptic voltage waveform leads to an increase in the number of Ca2+ ions entering the terminal per action potential and to a consecutive potentiation of evoked excitatory postsynaptic currents at MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels contributes to the control of efficacy of a glutamatergic synapse in the cortex."}],"publication_status":"published","author":[{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"extern":"1","quality_controlled":"1","citation":{"mla":"Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron, vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:10.1016/S0896-6273(00)00164-1.","apa":"Geiger, J., & Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00164-1","ieee":"J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 28, no. 3. Elsevier, pp. 927–939, 2000.","ama":"Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 2000;28(3):927-939. doi:10.1016/S0896-6273(00)00164-1","chicago":"Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00164-1.","short":"J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.","ista":"Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3), 927–939."},"year":"2000","publist_id":"2895","intvolume":" 28","status":"public","month":"12","date_created":"2018-12-11T12:03:37Z","issue":"3","volume":28,"publisher":"Elsevier","article_type":"original"},{"intvolume":" 84","publist_id":"2854","date_created":"2018-12-11T12:03:49Z","month":"07","status":"public","issue":"1","volume":84,"article_type":"original","publisher":"American Physiological Society","publication":"Journal of Neurophysiology","title":"Intracellular features predicted by extracellular recordings in the hippocampus in vivo","pmid":1,"_id":"3532","publication_status":"published","abstract":[{"lang":"eng","text":"Multichannel tetrode array recording in awake behaving animals provides a powerful method to record the activity of large numbers of neurons. The power of this method could be extended if further information concerning the intracellular state of the neurons could be extracted from the extracellularly recorded signals. Toward this end, we have simultaneously recorded intracellular and extracellular signals from hippocampal CA1 pyramidal cells and interneurons in the anesthetized rat. We found that several intracellular parameters can be deduced from extracellular spike waveforms. The width of the intracellular action potential is defined precisely by distinct points on the extracellular spike. Amplitude changes of the intracellular action potential are reflected by changes in the amplitude of the initial negative phase of the extracellular spike, and these amplitude changes are dependent on the state of the network. In addition, intracellular recordings from dendrites with simultaneous extracellular recordings from the soma indicate that, on average, action potentials are initiated in the perisomatic region and propagate to the dendrites at 1.68 m/s. Finally we determined that a tetrode in hippocampal area CA1 theoretically should be able to record electrical signals from similar to 1,000 neurons. Of these, 60-100 neurons should generate spikes of sufficient amplitude to be detectable from the noise and to allow for their separation using current spatial clustering methods. This theoretical maximum is in contrast to the approximately six units that are usually detected per tetrode. From this, we conclude that a large percentage of hippocampal CA1 pyramidal cells are silent in any given behavioral condition."}],"citation":{"mla":"Henze, Darrell, et al. “Intracellular Features Predicted by Extracellular Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology, vol. 84, no. 1, American Physiological Society, 2000, pp. 390–400, doi:10.1152/jn.2000.84.1.390.","apa":"Henze, D., Borhegyi, Z., Csicsvari, J. L., Mamiya, A., Harris, K., & Buzsáki, G. (2000). Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. American Physiological Society. https://doi.org/10.1152/jn.2000.84.1.390","ieee":"D. Henze, Z. Borhegyi, J. L. Csicsvari, A. Mamiya, K. Harris, and G. Buzsáki, “Intracellular features predicted by extracellular recordings in the hippocampus in vivo,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological Society, pp. 390–400, 2000.","ama":"Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. 2000;84(1):390-400. doi:10.1152/jn.2000.84.1.390","short":"D. Henze, Z. Borhegyi, J.L. Csicsvari, A. Mamiya, K. Harris, G. Buzsáki, Journal of Neurophysiology 84 (2000) 390–400.","chicago":"Henze, Darrell, Zsolt Borhegyi, Jozsef L Csicsvari, Akira Mamiya, Kenneth Harris, and György Buzsáki. “Intracellular Features Predicted by Extracellular Recordings in the Hippocampus in Vivo.” Journal of Neurophysiology. American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.390.","ista":"Henze D, Borhegyi Z, Csicsvari JL, Mamiya A, Harris K, Buzsáki G. 2000. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. Journal of Neurophysiology. 84(1), 390–400."},"quality_controlled":"1","author":[{"full_name":"Henze, Darrell","last_name":"Henze","first_name":"Darrell"},{"full_name":"Borhegyi, Zsolt","last_name":"Borhegyi","first_name":"Zsolt"},{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","first_name":"Jozsef L"},{"first_name":"Akira","last_name":"Mamiya","full_name":"Mamiya, Akira"},{"last_name":"Harris","first_name":"Kenneth","full_name":"Harris, Kenneth"},{"first_name":"György","last_name":"Buzsáki","full_name":"Buzsáki, György"}],"extern":"1","year":"2000","publication_identifier":{"issn":["0022-3077"]},"date_published":"2000-07-01T00:00:00Z","external_id":{"pmid":["10899213"]},"page":"390 - 400","doi":"10.1152/jn.2000.84.1.390","language":[{"iso":"eng"}],"acknowledgement":"We thank M. Recce for comments on the manuscript and J. Hetke and K.Wise for supplying us with the silicon probes (1P41RR09754).This work was supported by National Institutes of Health Grants NS-34994,MH-54671, and MH-12403 (to D. A. Henze), the Epilepsy Foundation of American (D. A.Henze), and an Eotvos fellowship (Z. Borhegyi).","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","date_updated":"2023-05-02T14:31:13Z","oa_version":"None","day":"01"},{"date_created":"2018-12-11T12:03:52Z","month":"11","status":"public","intvolume":" 28","publist_id":"2843","publication_identifier":{"issn":["0896-6273"]},"article_type":"original","publisher":"Elsevier","date_published":"2000-11-01T00:00:00Z","volume":28,"issue":"2","page":"585 - 594","publication_status":"published","abstract":[{"lang":"eng","text":"Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons."}],"title":"Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events","publication":"Neuron","language":[{"iso":"eng"}],"doi":"10.1016/S0896-6273(00)00135-5","_id":"3542","date_updated":"2023-05-02T14:26:07Z","type":"journal_article","oa_version":"None","day":"01","year":"2000","citation":{"apa":"Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5","mla":"Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5.","ama":"Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5","ieee":"J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events,” Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000.","ista":"Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2), 585–594.","chicago":"Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5.","short":"J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594."},"author":[{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","last_name":"Csicsvari"},{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"full_name":"Mamiya, Akira","first_name":"Akira","last_name":"Mamiya"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"extern":"1","article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1"},{"year":"2000","quality_controlled":"1","author":[{"first_name":"Kenneth","last_name":"Harris","full_name":"Harris, Kenneth"},{"last_name":"Henze","first_name":"Darrell","full_name":"Henze, Darrell"},{"first_name":"Jozsef L","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L"},{"full_name":"Hirase, Hajima","first_name":"Hajima","last_name":"Hirase"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"extern":"1","citation":{"apa":"Harris, K., Henze, D., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000). Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. American Physiological Society. https://doi.org/10.1152/jn.2000.84.1.401","mla":"Harris, Kenneth, et al. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology, vol. 84, no. 1, American Physiological Society, 2000, pp. 401–14, doi:10.1152/jn.2000.84.1.401.","chicago":"Harris, Kenneth, Darrell Henze, Jozsef L Csicsvari, Hajima Hirase, and György Buzsáki. “Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements.” Journal of Neurophysiology. American Physiological Society, 2000. https://doi.org/10.1152/jn.2000.84.1.401.","short":"K. Harris, D. Henze, J.L. Csicsvari, H. Hirase, G. Buzsáki, Journal of Neurophysiology 84 (2000) 401–414.","ista":"Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. 2000. Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. 84(1), 401–414.","ama":"Harris K, Henze D, Csicsvari JL, Hirase H, Buzsáki G. Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. Journal of Neurophysiology. 2000;84(1):401-414. doi:10.1152/jn.2000.84.1.401","ieee":"K. Harris, D. Henze, J. L. Csicsvari, H. Hirase, and G. Buzsáki, “Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements,” Journal of Neurophysiology, vol. 84, no. 1. American Physiological Society, pp. 401–414, 2000."},"publication_status":"published","abstract":[{"lang":"eng","text":"Simultaneous recording from large numbers of neurons is a prerequisite for understanding their cooperative behavior. Various recording techniques and spike separation methods are being used toward this goal. However, the error rates involved in spike separation have not yet been quantified. We studied the separation reliability of “tetrode” (4-wire electrode) recorded spikes by monitoring simultaneously from the same cell intracellularly with a glass pipette and extracellularly with a tetrode. With manual spike sorting, we found a trade-off between Type I and Type II errors, with errors typically ranging from 0 to 30% depending on the amplitude and firing pattern of the cell, the similarity of the waveshapes of neighboring neurons, and the experience of the operator. Performance using only a single wire was markedly lower, indicating the advantages of multiple-site monitoring techniques over single-wire recordings. For tetrode recordings, error rates were increased by burst activity and during periods of cellular synchrony. The lowest possible separation error rates were estimated by a search for the best ellipsoidal cluster shape. Human operator performance was significantly below the estimated optimum. Investigation of error distributions indicated that suboptimal performance was caused by inability of the operators to mark cluster boundaries accurately in a high-dimensional feature space. We therefore hypothesized that automatic spike-sorting algorithms have the potential to significantly lower error rates. Implementation of a semi-automatic classification system confirms this suggestion, reducing errors close to the estimated optimum, in the range 0-8%."}],"_id":"3548","title":"Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements","publication":"Journal of Neurophysiology","pmid":1,"publisher":"American Physiological Society","article_type":"original","issue":"1","volume":84,"status":"public","date_created":"2018-12-11T12:03:54Z","month":"07","publist_id":"2837","intvolume":" 84","day":"01","type":"journal_article","date_updated":"2023-05-02T14:16:45Z","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","acknowledgement":"The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked ‘‘advertisement’ ’in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. We thank R. Bruno for performing cluster analysis and drawing our attention to the AutoClass program, M. Recce and P. Mitra for suggestions withdata analysis and comments on the manuscript, C. King, G. Dragoi, and X.Leinekugel for performing cluster analysis, and J. Hetke and K. Wise for supplying silicon probes. The data used in this paper are available on request by e-mail to G. Buzsaki. This work was supported by National Institutes of Health Grants NS-34994,413 MH-54671, and MH-12403 (to D. A. Henze) and by the Epilepsy Foundationof America (to D. A. Henze).","language":[{"iso":"eng"}],"doi":"10.1152/jn.2000.84.1.401","page":"401 - 414","date_published":"2000-07-01T00:00:00Z","external_id":{"pmid":["10899214 "]},"publication_identifier":{"issn":["0022-3077"]}},{"publisher":"ACM","page":"273 - 277","date_published":"2000-06-01T00:00:00Z","status":"public","date_created":"2018-12-11T12:03:56Z","conference":{"location":"Portland, OR, USA","start_date":"2000-05-21","name":"STOC: Symposium on the Theory of Computing","end_date":"2000-05-23"},"month":"06","publist_id":"2830","publication_identifier":{"isbn":["9781581131840"]},"scopus_import":"1","day":"01","year":"2000","date_updated":"2023-05-02T14:07:00Z","type":"conference","oa_version":"None","quality_controlled":"1","article_processing_charge":"No","author":[{"full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","first_name":"Herbert","last_name":"Edelsbrunner"},{"full_name":"Li, Xiang","id":"4B7E523C-F248-11E8-B48F-1D18A9856A87","first_name":"Xiang","last_name":"Li"},{"first_name":"Gary","last_name":"Miller","full_name":"Miller, Gary"},{"full_name":"Stathopoulos, Andreas","last_name":"Stathopoulos","first_name":"Andreas"},{"full_name":"Talmor, Dafna","first_name":"Dafna","last_name":"Talmor"},{"first_name":"Shang","last_name":"Teng","full_name":"Teng, Shang"},{"full_name":"Üngör, Alper","first_name":"Alper","last_name":"Üngör"},{"last_name":"Walkington","first_name":"Noel","full_name":"Walkington, Noel"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","citation":{"ieee":"H. Edelsbrunner et al., “Smoothing and cleaning up slivers,” in Proceedings of the 32nd annual ACM symposium on Theory of computing, Portland, OR, USA, 2000, pp. 273–277.","ama":"Edelsbrunner H, Li X, Miller G, et al. Smoothing and cleaning up slivers. In: Proceedings of the 32nd Annual ACM Symposium on Theory of Computing. ACM; 2000:273-277. doi:10.1145/335305.335338","short":"H. Edelsbrunner, X. Li, G. Miller, A. Stathopoulos, D. Talmor, S. Teng, A. Üngör, N. Walkington, in:, Proceedings of the 32nd Annual ACM Symposium on Theory of Computing, ACM, 2000, pp. 273–277.","chicago":"Edelsbrunner, Herbert, Xiang Li, Gary Miller, Andreas Stathopoulos, Dafna Talmor, Shang Teng, Alper Üngör, and Noel Walkington. “Smoothing and Cleaning up Slivers.” In Proceedings of the 32nd Annual ACM Symposium on Theory of Computing, 273–77. ACM, 2000. https://doi.org/10.1145/335305.335338.","ista":"Edelsbrunner H, Li X, Miller G, Stathopoulos A, Talmor D, Teng S, Üngör A, Walkington N. 2000. Smoothing and cleaning up slivers. Proceedings of the 32nd annual ACM symposium on Theory of computing. STOC: Symposium on the Theory of Computing, 273–277.","mla":"Edelsbrunner, Herbert, et al. “Smoothing and Cleaning up Slivers.” Proceedings of the 32nd Annual ACM Symposium on Theory of Computing, ACM, 2000, pp. 273–77, doi:10.1145/335305.335338.","apa":"Edelsbrunner, H., Li, X., Miller, G., Stathopoulos, A., Talmor, D., Teng, S., … Walkington, N. (2000). Smoothing and cleaning up slivers. In Proceedings of the 32nd annual ACM symposium on Theory of computing (pp. 273–277). Portland, OR, USA: ACM. https://doi.org/10.1145/335305.335338"},"publication_status":"published","abstract":[{"lang":"eng","text":"A sliver is a tetrahedron whose four vertices lie close to a plane and whose perpendicular projection to that plane is a convex quadrilateral with no short edge. Slivers are both undesirable and ubiquitous in 3-dimensional Delaunay triangulations. Even when the point-set is well-spaced, slivers may result. This paper shows that such a point set permits a small perturbation whose Delaunay triangulation contains no slivers. It also gives deterministic algorithms that compute the perturbation of n points in time O(n log n) with one processor and in time O(log n) with O(n) processors."}],"language":[{"iso":"eng"}],"doi":"10.1145/335305.335338","_id":"3555","title":"Smoothing and cleaning up slivers","publication":"Proceedings of the 32nd annual ACM symposium on Theory of computing"},{"publication_identifier":{"isbn":["3851653580"]},"publist_id":"2813","date_created":"2018-12-11T12:04:01Z","month":"01","status":"public","date_published":"2000-01-01T00:00:00Z","page":"153 - 171","publisher":"Passagen Verlag","title":"Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung","publication":"Zur Kunst des formalen Denkens","language":[{"iso":"eng"}],"_id":"3572","publication_status":"published","abstract":[{"lang":"eng","text":"Allzulange wurde die spielhafte Beschäftigung als Gegensatz zu ernsthafter Arbeit gesehen. Dieser Artikel propagiert die spielerische Untersuchung von Kreis- und Kugelmengen. Gleichzeitig belegt er die nutzbare Anwendung\r\nvon elementaren Einsichten in der Molekularbiologie und allgemeiner\r\nin der Beschreibung von Form und Verformung."}],"citation":{"mla":"Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form Und Verformung.” Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000, pp. 153–71.","apa":"Edelsbrunner, H. (2000). Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung. In Zur Kunst des formalen Denkens (pp. 153–171). Passagen Verlag.","ista":"Edelsbrunner H. 2000.Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung. In: Zur Kunst des formalen Denkens. , 153–171.","short":"H. Edelsbrunner, in:, Zur Kunst Des Formalen Denkens, Passagen Verlag, 2000, pp. 153–171.","chicago":"Edelsbrunner, Herbert. “Spielereien Mit Kreisen Und Kugeln. Zum Thema Form Und Verformung.” In Zur Kunst Des Formalen Denkens, 153–71. Passagen Verlag, 2000.","ama":"Edelsbrunner H. Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung. In: Zur Kunst Des Formalen Denkens. Passagen Verlag; 2000:153-171.","ieee":"H. Edelsbrunner, “Spielereien mit Kreisen und Kugeln. Zum Thema Form und Verformung,” in Zur Kunst des formalen Denkens, Passagen Verlag, 2000, pp. 153–171."},"article_processing_charge":"No","author":[{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9823-6833","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","last_name":"Edelsbrunner"}],"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","date_updated":"2023-05-02T13:07:14Z","type":"book_chapter","oa_version":"None","day":"01","year":"2000"},{"intvolume":" 9","publist_id":"2802","scopus_import":"1","date_created":"2018-12-11T12:04:05Z","month":"03","status":"public","date_published":"2000-03-21T00:00:00Z","volume":9,"page":"133 - 213","publisher":"Cambridge University Press","title":"Triangulations and meshes in computational geometry","publication":"Acta Numerica","language":[{"iso":"eng"}],"doi":"10.1017/S0962492900001331","_id":"3583","acknowledgement":"Research is partially supported by the Army Research Office under grant DAAG55-98-1-0177 and by the National Science Foundation under grants CCR-96-19542 and CCR-97-12088.","publication_status":"published","abstract":[{"text":"The Delaunay triangulation of a finite point set is a central theme in computational geometry. It finds its major application in the generation of meshes used in the simulation of physical processes. This paper connects the predominantly combinatorial work in classical computational geometry with the numerical interest in mesh generation. It focuses on the two- and three-dimensional case and covers results obtained during the twentieth century.","lang":"eng"}],"citation":{"apa":"Edelsbrunner, H. (2000). Triangulations and meshes in computational geometry. Acta Numerica. Cambridge University Press. https://doi.org/10.1017/S0962492900001331","mla":"Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.” Acta Numerica, vol. 9, Cambridge University Press, 2000, pp. 133–213, doi:10.1017/S0962492900001331.","ista":"Edelsbrunner H. 2000. Triangulations and meshes in computational geometry. Acta Numerica. 9, 133–213.","short":"H. Edelsbrunner, Acta Numerica 9 (2000) 133–213.","chicago":"Edelsbrunner, Herbert. “Triangulations and Meshes in Computational Geometry.” Acta Numerica. Cambridge University Press, 2000. https://doi.org/10.1017/S0962492900001331.","ama":"Edelsbrunner H. Triangulations and meshes in computational geometry. Acta Numerica. 2000;9:133-213. doi:10.1017/S0962492900001331","ieee":"H. Edelsbrunner, “Triangulations and meshes in computational geometry,” Acta Numerica, vol. 9. Cambridge University Press, pp. 133–213, 2000."},"article_processing_charge":"No","author":[{"last_name":"Edelsbrunner","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"}],"quality_controlled":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","date_updated":"2023-05-02T12:20:27Z","oa_version":"None","day":"21","year":"2000"},{"publication_identifier":{"issn":["0016-6723"]},"scopus_import":"1","page":"297 - 314","date_published":"2000-06-01T00:00:00Z","external_id":{"pmid":["10893866"]},"doi":"10.1017/S0016672399004346","language":[{"iso":"eng"}],"acknowledgement":"This work was supported by grant GR31/G09821 from the BBSRC, and by fellowships from the Darwin Trust of Edinburgh and the NERC. We are grateful to the referees for their helpful comments on the manuscript.","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","day":"01","date_updated":"2023-05-02T12:09:23Z","type":"journal_article","oa_version":"None","publist_id":"2760","intvolume":" 75","status":"public","date_created":"2018-12-11T12:04:18Z","month":"06","issue":"3","volume":75,"publisher":"Cambridge University Press","article_type":"original","_id":"3623","title":"Measuring fitness by means of balancer chromosomes","publication":"Genetical Research","pmid":1,"publication_status":"published","abstract":[{"lang":"eng","text":"We present the theoretical background to a new method for measuring genetic variation for total fitness in Drosophila. The method allows heterozygous effects on total fitness of whole wild-type chromosomes to be measured under normal demography with overlapping generations. The wild-type chromosomes are competed against two balancer chromosomes (B1, B2, say), providing a standard genotype B1/B2 against which variation in the fitness effects of the wild-type chromosomes can be assessed. Fitness can be assessed in two ways: (i) at equilibrium of all three chromosomes under heterozygote advantage, and (ii) during displacement of one balancer by the other. Equilibrium with all three chromosomes present will be achieved only if the wild-type homozygote is not too fit, and if the fitnesses of the three heterozygotes are not too unequal. These conditions were not satisfied for any of a sample of 12 lethal-bearing chromosomes isolated from a random-bred laboratory population of Drosophila. At equilibrium, genotypic frequencies show low sensitivity to changes in genotypic fitness. Furthermore, where all four genotypes are viable and fertile, supplementary information from cages with only two chromosomes present and from direct measurements of pre-adult viability are required to estimate fitnesses from frequencies. The invasion method has the advantages of a greater sensitivity and of not requiring further data to estimate fitnesses if the wild-type homozygote is fertile. However, it requires that multiple samples be taken as the invasion progresses. In a discrete generation model, generation time influences fitness estimates from this method and is difficult to estimate accurately from the data. A full age-structured model can also be applied to the data from both types of experiment. For the invasion method, this gives fitness estimates close to those from the discrete generation model."}],"author":[{"last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Patridge, Linda","first_name":"Linda","last_name":"Patridge"}],"extern":"1","quality_controlled":"1","citation":{"ista":"Barton NH, Patridge L. 2000. Measuring fitness by means of balancer chromosomes. Genetical Research. 75(3), 297–314.","chicago":"Barton, Nicholas H, and Linda Patridge. “Measuring Fitness by Means of Balancer Chromosomes.” Genetical Research. Cambridge University Press, 2000. https://doi.org/10.1017/S0016672399004346.","short":"N.H. Barton, L. Patridge, Genetical Research 75 (2000) 297–314.","ieee":"N. H. Barton and L. Patridge, “Measuring fitness by means of balancer chromosomes,” Genetical Research, vol. 75, no. 3. Cambridge University Press, pp. 297–314, 2000.","ama":"Barton NH, Patridge L. Measuring fitness by means of balancer chromosomes. Genetical Research. 2000;75(3):297-314. doi:10.1017/S0016672399004346","apa":"Barton, N. H., & Patridge, L. (2000). Measuring fitness by means of balancer chromosomes. Genetical Research. Cambridge University Press. https://doi.org/10.1017/S0016672399004346","mla":"Barton, Nicholas H., and Linda Patridge. “Measuring Fitness by Means of Balancer Chromosomes.” Genetical Research, vol. 75, no. 3, Cambridge University Press, 2000, pp. 297–314, doi:10.1017/S0016672399004346."},"year":"2000"}]